Issues That Matter Most!

Total Page:16

File Type:pdf, Size:1020Kb

Issues That Matter Most! ISSUES THAT MATTER MOST! ...WHILE PUTTING THE PIECES TOGETHER AND LEARNING HOW TO SEE FULLY WHAT WE SEE... ISSUE V COCAINE: HISTORY & IMPACT 'Fire Fly in the Dark' – also known as Gord 'Cat in the Hat' Zaretzki!) Find me @ > [email protected] MEET THE PUBLISHER: The views expressed herein are not entirely the views of the publisher (the clues are in the links. The links contain the pieces to the puzzle.) Fire Fly in the Dark' – Also known as Gord 'Cat in the Hat' Zaretzki!) Contact Info: Username: Flyer Fly in the Dark@ http://www.scribd.com/group/66708-issues-that-matter-most / (Publishers Network Group) http://issuesthatmattermost.ning.com/ (Global Activism Social Network) http://fire-fly-in-the-dark.webs.com/ (Website) Email: [email protected]/ PAST ISSUES OF 'ISSUES'...... • ISSUE I : Meet PLANET 'X' (NIBURU) http://www.scribd.com/doc/12315456/issues-that-matter-most-first- edition • ISSUE II : CHEMtrails http://www.scribd.com/doc/10120388/issues-that-matter- most-second-edition • ISSUE III: POISONS http://www.scribd.com/doc/12315064/issues-that-matter- most-3rd-edition-poisons • ISSUE IV: PLANET X (And more on what to expect for the year 2012) http://www.scribd.com/doc/13484949/ISSUES-THAT-MATTER-MOST-4th- Edition-PLANET-X-2012-part-2 Office: My Portable Laptop Location:The Information Highway COME SOLVE THIS RIDDLE I'M CAUGHT IN THE MIDDLE BUT TAKE IT ALL IN STRIDE AND HOLD ON FOR THE RIDE! SOME OF THE LATEST ISSUES AND PERTINENT NEWS THAT MATTER MOST IN 'ISSUES' FOR APRIL... Canadian Corruption - Sexual Abuse & Political & Legal Conspiracy. RCMP Incompetence & Cover up. Priors Of Grand Bank NFLD Canada • Added by Fire Fly in the Dark on March 17, 2009 at 1:50am http://issuesthatmattermost.ning.com/notes/index/show?noteKey=Canadian_Corruption_- _Sexual_Abuse_%26_Political_%26_Legal_Conspiracy._RCMP_Incompetence_%26_Cover_up._Priors_ Of_Grand_Bank_NFLD_Canada Government Transparency • Added by Fire Fly in the Dark on March 24, 2009 at 3:32am http://issuesthatmattermost.ning.com/notes/Government_Transparency What makes You Happy • Added by David Klamph on March 23, 2009 at 4:48pm http://issuesthatmattermost.ning.com/video/what-makes-you-happy Girl Who Silenced the UN For 5 Minutes • Added by Fire Fly in the Dark on March 23, 2009 at 3:43pm http://issuesthatmattermost.ning.com/video/girl-who-silenced-the-un-for-5 Cool music • Added by David Klamph on March 23, 2009 at 9:54am http://issuesthatmattermost.ning.com/video/cool-music The Law of ONE • Added by Fire Fly in the Dark on March 21, 2009 at 2:05am http://issuesthatmattermost.ning.com/video/the-law-of-one Senator Amy Klobuchar On A.I.G. Bonuses • Added by Fire Fly in the Dark on March 23, 2009 at 5:29pm http://issuesthatmattermost.ning.com/video/senator-amy-klobuchar-on-aig Pink Floyd - Earth Soldier - World Peace Song 2009 - esoldier HD • Added by Fire Fly in the Dark on March 6, 2009 at 4:05am http://issuesthatmattermost.ning.com/video/pink-floyd-earth-soldier Why you should buy physical gold/silver, not paper ETFs - David Morgan http://issuesthatmattermost.ning.com/video/why-you-should-buy-physical COCAINE: HISTORY & IMPACT The Brain on Cocaine These two images of the brain are positron emission tomography (PET) scans of a normal person (picture on the left) and of a person on cocaine (picture on the right). The PET scan shows brain function by seeing how the brain uses glucose, the energy source for neurons. In these scans, the red color shows high use of glucose, yellow shows medium use and blue shows the least use of glucose. Notice that many areas of the brain of the cocaine user do not use glucose as effectively as the brain of the normal person. This can be observed by the lower amounts of red in the right PET scan. Image courtesy of the National Institute on Drug Abuse; used with permission. LOOK! By Gord Zaretzki Look in! Look out! Look up and Look down! ...Look all around At the sights and the sounds! Can you see? Can you hear? What seemed far is now near Take it all in. Give it all back. Make it without but never lack! For the image remains and will be retained. If the will to regain is mutually maintained! Yes together we can make it! And we'll never need to fake it! For we have seen and learned Though we first crashed and burned So to once again return to a high from a low We must be certain just where we will go! So... Look in! Look out! Look up and Look down! ...Look all around At the sights and the sounds! Breakdown of what will be discussed in this issue of ISSUES THAT MATTER MOST! ➢THE HISTORY OF COCAINE First of all I would like to introduce the history of what led up to my choosing to publish an issue of 'Issues' dealing with Cocaine... I know that there are a lot of drugs out there. Some are used medicinally. Others are used recreationally. Some are helpful for certain aspects of life. Others are nothing but trouble (with a capital 'T'!) The reason I chose to isolate this particular drug is due to my particular interest in it. Now my interests differ drastically from the way I used to be interested in cocaine! In the past I was a slave to this stimulant drug – particularly to it's 'offspring', CRACK. It took me down a 'rabbit hole' the sorts of which left me floundering for air like a fish out of water, as it were, when I was done with it (or rather.. as it was done with me!!!). I found myself out of sorts, out of place, out of my 'time' and out of my mind once it took me, partook of me and then forsook me. Sure, I took it too and embraced it lovingly as I partook of it emphatically until I finally forsook it back. But before I could accomplish this I had to tumble down the 'rabbit hole' to near death. In fact I feel that I did die... literally in the emotional and spiritual sense. Then I nearly physically died when my heart stopped – not once but twice! In between, for many minutes before and many minutes after, as well, my heart was barely beating – pumping very weakly for only a few feable beats a minute..... A friend and fellow confrere from this labyrinthal world of chaos (the life and times of crack enslavement) approached me while I was still working on finishing up the last issue of 'Issues' expressing his concern over this epidemic inflicting itself on the town that we both grew up in – as we so often do. I had not spoken much with this friend, Jimmy, since moving from the town that he still lives in but I moved from (for the 6th or 7th time!). Since speaking last about this we both had made more positive progress since those dark and deadly days of addiction to one of the world's most powerful drugs. Both of us now have a few years clean and healing from the devastating effects of such a life. In addition to staying away from it we have both tried different ways to spread the message of why it's so vital to stay away from such a course as well as how to break free should one find one's self enslaved to the evil world enveloping and permeating cocaine/crack addiciton. Currently Jimmy is taking steps to get into politics in the local community. In so doing he wishes to raise awareness to crack, cocaine, it's history, impact and how to break free from it. Our home town has been plagued by gang activity with it's ensuing crimes and moral breakdowns of family and community. Included among the crimes and moral breakdowns is the impact of the drug on the people there. I will discuss these details in the next section though along with it's impact world-wide. My near death experience I will discuss in this section and my path of addiction with relationship to this very powerful drug as well as the history of cocaine itself. Some of the history will be revealing as well as surprising. Included in the discussion will be origins (past and present), methods and avenues of its circulation world-wide and how it has developed through shape and form into the lives of so many over the years. ➢THE IMPACT OF COCAINE After giving you a rundown of how I was run down by cocaine (particularly CRACK)in the last section I will share with you generally what happens to one when they so decide to take the 'highway to hell' by enlisting one's soul in this soul devouring course. I will portray the impact of this drug as I have seen it and experienced it in my personal life, in my home town, on the streets of the cities I have wandered as well as what is happening around the world with regards to how this drug is effecting the lives of so many in a devastating and destructive way. I will take into account it's effects physically, emotionally and spiritually. I will prove that it is not something to be taken lightly, that it is far different from cannabis and even more harmful to society then alcohol even though fewer abuse this drug compared to alcohol. In so doing I will compare it's effects to those of other popular vices such as alcoholism, addiction to 'softer' drugs (like marijuanna, hash, hash oil etc), other 'hard' drugs (such as heroin, crystal meth, ecstacy, LSD etc), cigarettes, pharmaceuticals and gambling.
Recommended publications
  • INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Summary Report
    INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Summary Report SEIZED MATERIALS 2016/1 INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Table of contents Sample 1 Analysis Page 6 Identified substances Page 6 Statement of findings Page 11 Identification methods Page 20 False positives Page 26 Z-Scores Page 27 Sample 2 Analysis Page 31 Identified substances Page 31 Statement of findings Page 36 Identification methods Page 46 False positives Page 52 Z-Scores Page 53 Sample 3 Analysis Page 56 Identified substances Page 56 Statement of findings Page 61 Identification methods Page 70 False positives Page 76 Z-Scores Page 77 Sample 4 Analysis Page 80 Identified substances Page 80 Statement of findings Page 82 Identification methods Page 88 False positives Page 94 Z-Scores Page 95 Test Samples Information Samples Comments on samples Sample 1 SM-1 was prepared from a seizure containing 50.5 % (w/w) Cocaine base. The test sample also contained caffeine and levamisole. Benzoylecgonine and cinnamoyl cocaine were also detected as minor components. Sample 2 SM-2 was prepared from a seizure containing 13.8 % (w/w) MDMA. The test sample also contained lactose. Sample 3 SM-3 was prepared from a seizure containing 5.5 % (w/w) Amfetamine base. The test sample also contained caffeine and creatine. Sample 4 SM-4 wss a blank test sample prepared from plant material and contained no substances from the ICE menu Samples Substances Concentrations Comments on substances Sample 1 Caffeine - Quantification not required Cocaine 50.5 % Sample 2 3,4-Methylenedioxymetamfetamine (MDMA) 13.8 % Lactose - Quantification not required Sample 3 Amfetamine 5.5 % Caffeine - Quantification not required Sample 4 [blank sample] 2 2016/1-SM Copyright (c) 2016 UNODC Introduction An important element of the UNODC International Quality Assurance Programme (IQAP) is the implementation of the International Collaborative Exercises (ICE).
    [Show full text]
  • Glutathione Conjugation of a Cocaine Pyrolysis Product AEME and Related Compounds
    Graduate Theses, Dissertations, and Problem Reports 2005 Glutathione conjugation of a cocaine pyrolysis product AEME and related compounds Alan Lewis Myers West Virginia University Follow this and additional works at: https://researchrepository.wvu.edu/etd Recommended Citation Myers, Alan Lewis, "Glutathione conjugation of a cocaine pyrolysis product AEME and related compounds" (2005). Graduate Theses, Dissertations, and Problem Reports. 2250. https://researchrepository.wvu.edu/etd/2250 This Dissertation is protected by copyright and/or related rights. It has been brought to you by the The Research Repository @ WVU with permission from the rights-holder(s). You are free to use this Dissertation in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you must obtain permission from the rights-holder(s) directly, unless additional rights are indicated by a Creative Commons license in the record and/ or on the work itself. This Dissertation has been accepted for inclusion in WVU Graduate Theses, Dissertations, and Problem Reports collection by an authorized administrator of The Research Repository @ WVU. For more information, please contact [email protected]. GLUTATHIONE CONJUGATION OF A COCAINE PYROLYSIS PRODUCT AEME AND RELATED COMPOUNDS Alan Lewis Myers A DISSERTATION Submitted to The School of Pharmacy At West Virginia University In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Pharmaceutical Sciences Patrick S. Callery, Ph.D.,
    [Show full text]
  • M1 and M3 Muscarinic Receptors May Play a Role in the Neurotoxicity Of
    www.nature.com/scientificreports OPEN M1 and M3 muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, Received: 27 July 2015 Accepted: 02 November 2015 a cocaine pyrolysis product Published: 02 December 2015 Raphael Caio Tamborelli Garcia1,2,6,7,*, Livia Mendonça Munhoz Dati1,*, Larissa Helena Torres1, Mariana Aguilera Alencar da Silva1, Mariana Sayuri Berto Udo1, Fernando Maurício Francis Abdalla3, José Luiz da Costa4, Renata Gorjão5, Solange Castro Afeche3, Mauricio Yonamine1, Colleen M. Niswender6,7, P. Jeffrey Conn6,7, Rosana Camarini8, Maria Regina Lopes Sandoval3 & Tania Marcourakis1 The smoke of crack cocaine contains cocaine and its pyrolysis product, anhydroecgonine methyl ester (AEME). AEME possesses greater neurotoxic potential than cocaine and an additive effect when they are combined. Since atropine prevented AEME-induced neurotoxicity, it has been suggested that its toxic effects may involve the muscarinic cholinergic receptors (mAChRs). Our aim is to understand the interaction between AEME and mAChRs and how it can lead to neuronal death. Using a rat primary hippocampal cell culture, AEME was shown to cause a concentration-dependent increase on both total [3H]inositol phosphate and intracellular calcium, and to induce DNA fragmentation after 24 hours of exposure, in line with the activation of caspase-3 previously shown. Additionally, we assessed AEME activity at rat mAChR subtypes 1–5 heterologously expressed in Chinese Hamster Ovary cells. l-[N-methyl-3H]scopolamine competition binding showed a preference of AEME for the M2 subtype; calcium mobilization tests revealed partial agonist effects at 1M and M3 and antagonist activity at the remaining subtypes. The selective M1 and M3 antagonists and the phospholipase C inhibitor, were able to prevent AEME-induced neurotoxicity, suggesting that the toxicity is due to the partial agonist effect at 1M and M3 mAChRs, leading to DNA fragmentation and neuronal death by apoptosis.
    [Show full text]
  • Microgram Journal
    U.S. Department of Justice Drug Enforcement Administration www.dea.gov Microgram Journal To Assist and Serve Scientists Concerned with the Detection and Analysis of Controlled Substances and Other Abused Substances for Forensic / Law Enforcement Purposes. Published by: The U.S. Attorney General has determined that the publication of this The Drug Enforcement Administration periodical is necessary in the transaction of the public business Office of Forensic Sciences required by the Department of Justice. Information, instructions, and Washington, DC 20537 disclaimers are published in the first issue of each year. Volume 3 Numbers 3-4 Posted On-Line At: July - December 2005 www.dea.gov/programs/forensicsci/microgram/index.html Contents Analysis and Characterization of Designer Tryptamines using Electrospray Ionization 107 Mass Spectrometry (ESI-MS) Sandra E. Rodriguez-Cruz Assessment of the Volatility (Smokeability) of Cocaine Base Containing 50 Percent 130 Mannitol: Is it a Smokeable Form of “Crack” Cocaine? John F. Casale Levamisole: An Analytical Profile 134 Ann Marie M. Valentino and Ken Fuentecilla Rapid Chiral Separation of Dextro- and Levo- Methorphan using Capillary 138 Electrophoresis with Dynamically Coated Capillaries Ira S. Lurie and Kimberly A. Cox Reduction of Phenylephrine with Hydriodic Acid/Red Phosphorus or Iodine/ 142 Red Phosphorus: 3-Hydroxy-N-methylphenethylamine Lisa M. Kitlinski, Amy L. Harman, Michael M. Brousseau, and Harry F. Skinner Synthesis of trans-4-Methylaminorex from Norephedrine and Potassium Cyanate 154 Walter R. Rodriguez and Russell A. Allred Identification of a New Amphetamine Type Stimulant: 3,4-Methylenedioxy- 166 (2-hydroxyethyl)amphetamine (MDHOET) Carola Koper*, Elisa Ali-Tolppa, Joseph S. Bozenko Jr., Valérie Dufey, Michael Puetz, Céline Weyermann, Frantisek Zrcek Analysis and Characterization of Psilocybin and Psilocin Using Liquid 175 Chromatography - Electrospray Ionization Mass Spectrometry (LC-ESI-MS) with Collision-Induced-Dissociation (CID) and Source-Induced-Dissociation (SID) Sandra E.
    [Show full text]
  • Methylecgonidine Coats the Crack Particle
    Pharmacology Biochemistry and Behavior, Vol. 53, No. I, pp. 57-66, 1996 Copyright 0 1995 Elsevier Science Inc. Printed in the USA. All rights reserved 009-3057196 $15.00 + .OO 0091-3057(95)00198-0 Methylecgonidine Coats the Crack Particle RONALD W. WOOD,’ JALIL SHOJAIE, CHING PING FANG AND JOHN F. GRAEFE Nelson Institute, Department of Environmental Medicine, NYU Medical Center, Tuxedo, NY 10987 Received 9 November 1994; Revised 30 March 1995; Accepted 6 April 1995 WOOD, R. W., J. SHOJAIE, C. P. FANG AND J. F. GRAEFE. Methylecgonidine coats the crackparticle. PHAR- MACOL BIOCHEM BEHAV 53(l) 57-66, 1996.-Crack is a form of cocaine base self-administered by smoking. When heated, it volatilizes and may partially pyrolyze to methylecgonidine (MEG). Upon cooling, a condensation aerosol forms. Heating cocaine base in model crack pipes produced particles of about 1 pm in diameter, regardless of the amount heated; however, MEG concentration increased from ~2% at 10 mg per heating to as much as 5% at 30 mg per heating. Methylecgon- idine was 5 1% of the recovered material when cocaine was vaporized off a heated wire coil, but the particles were larger (2-5 pm), and the distribution disperse. The vapor pressure of MEG was higher [log P(mm Hg) = 9.994 - 3530/T] than cocaine base, consistent with MEG coating the droplet during condensation, and with evaporation during aging or dilution. Disappearance of MEG from a chamber filled with crack smoke was a two-component process, one proceeding at the rate of cocaine particle removal, and the other at the desorption rate from other surfaces.
    [Show full text]
  • Acute Cocaine Intoxication: Current Methods of Treatment, Bethesda, MD, July 9-10, 1991
    National Institute on Drug Abuse RESEARCH MONOGRAPH SERIES Acute Cocaine Intoxication: Current Methods of Treatment 123 U.S. Department of Health and Human Services • Public Health Service • National Institutes of Health Acute Cocaine Intoxication: Current Methods of Treatment Editor: Heinz Sorer, Ph.D. NIDA Research Monograph 123 1992 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health National Institute on Drug Abuse 5600 Fishers Lane Rockville, MD 20857 ACKNOWLEDGMENT This Monograph is based on the papers and discussions from a technical review on “Acute Cocaine Intoxication: Current Methods of Treatment” held on July 9-10, 1991, in Bethesda, MD. The technical review was sponsored by the National Institute on Drug Abuse (NIDA). COPYRIGHT STATUS The National Institute on Drug Abuse has obtained permission from the copyright holders to reproduce certain previously published materials as noted in the text. Further reproduction of this copyrighted material is permitted only as part of a reprinting of the entire publication or chapter. For any other use, the copyright holder’s permission is required. All other material in this volume except quoted passages from copyrighted sources is in the public domain and may be used or reproduced without permission from the Institute or the authors. Citation of the source is appreciated. Opinions expressed in this volume are those of the authors and do not necessarily reflect the opinions or official policy of the National Institute on Drug Abuse or any other part of the U.S. Department of Health and Human Services. The U.S. Government does not endorse or favor any specific commercial product or company.
    [Show full text]
  • Problems of Drug Dependence 1999: Proceedings of the 61St Annual Scientific Meeting the College on Problems
    RESEARCH MONOGRAPH SERIES Problems of Drug Dependence 1999: Proceedings of the 61st Annual Scientific Meeting The College on Problems of Drug Dependence, Inc. U.S. Department of Health and Human 1Services80 • National Institutes of Health Problems of Drug Dependence, 1999: Proceedings of the 61st Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc. Editor: Louis S. Harris, Ph.D. Virginia Commonwealth University NIDA Research Monograph 180 1999 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Drug Abuse 6001 Executive Boulevard Bethesda, MD 20892 ACKNOWLEDGEMENT The College on Problems of Drug Dependence, Inc., an independent, non-profit organization conducts drug testing and evaluations for academic institutions, government, and industry. This monograph is based on papers or presentations from the 61st Annual Scientific Meeting of the CPDD, held in Acapulco, Mexico, June 12-17, 1999. In the interest of rapid dissemination, it is published by the National Institute on Drug Abuse in its Research Monograph series as reviewed and submitted by the CPDD. Dr. Louis S. Harris, Department of Pharmacology and Toxicology, Virginia Commonwealth University was the editor of this monograph. COPYRIGHT STATUS The National Institute on Drug Abuse has obtained permission from the copyright holders to reproduce certain previously published materials as noted in the text. Further reproduction of this copyrighted material is permitted only as part of a reprinting of the entire publication or chapter. For any other use, the copyright holder’s permission is required. All other material in this volume except quoted passages from copyrighted sources is in the public domain and may be used or reproduced without permission from the Institute or the authors.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 8.481,518 B2 Wood (45) Date of Patent: Jul
    USOO8481.518B2 (12) United States Patent (10) Patent No.: US 8.481,518 B2 WOOd (45) Date of Patent: Jul. 9, 2013 (54) QUATERNARY ANTIMUSCARINIC FOREIGN PATENT DOCUMENTS COMPOUNDS FOR THE TREATMENT OF WO WO98/OO133 1, 1998 BLADDER DISEASES WO WO98/OO138 1, 1998 WO WOO245711 A1 * 6, 2002 (75) Inventor: Ronald W. Wood, Rochester, NY (US) OTHER PUBLICATIONS (73) Assignee: University of Rochester, Rochester, NY Disse et al. (Life Sciences, 1993, 52/5-6:537-544).* (US) Deaney et al., JNeurolNeurosurg Psychiatry, abstract, 1998,65:957 958.* (*) Notice: Subject to any disclaimer, the term of this Walter et al., Neurourology and Urodynamics, 18:447-453, 1999.* patent is extended or adjusted under 35 Kuo, H.C. J. Formos. Med. Assoc. (May 2001), 100(5), 309-14 U.S.C. 154(b) by 1721 days. (abstract).* Chuang et al., Journal of Urology, (Oct. 2009), 182(4), 1393-400.* (21) Appl. No.: 10/542,501 "Anticholinergic Therapy: The State of the Art. Proceedings of a Symposium Held in Stratford-Upon Avon Sep. 8-9, 1986.” (22) PCT Filed: Jan. 15, 2004 Higgenbottam et al., eds. Postgrad. Med. J. 63(Suppl 1): 1-86 and Poster Abstracts and Discussion 63(Suppl 1): 1A-31A (1987). (86). PCT No.: PCT/US2OO4/OOO961 Autret et al., “Plasma Levels of Oxybutynine Chloride in Children.” Eur: J. Clin. Pharmacol. 46:83-85 (1994). S371 (c)(1), Barbalias, G.A., “Interstitial Cystitis: Bladder Training with (2), (4) Date: Jan. 10, 2006 Intravesical Oxybutynin.” J. Urol. 163:1818-1822 (2000). Brendler et al., “Topical Oxybutynin Chloride for Relaxation of (87) PCT Pub.
    [Show full text]
  • Validation of Oral Fluid As a Matrix for Drug Detection – Copyright Statement
    Validation of Oral Fluid as a Matrix for Drug Detection Eva Maria Reichardt A thesis submitted in partial fulfilment of the requirements of Bournemouth University for the degree of Doctor of Philosophy Validation of Oral Fluid as a Matrix for Drug Detection – Copyright Statement This copy of the thesis has been supplied on condition that anyone who consults it is understood to recognise that its copyright rests with its author and due acknowledgement must always be made of the use of any material contained in, or derived from, this thesis. ii Validation of Oral Fluid as a Matrix for Drug Detection - Dedication This thesis is dedicated with great gratitude to my father Horst, my mother Conny, my sister Anne and my partner Tim for always encouraging me to be the best I can be. iii Validation of Oral Fluid as a Matrix for Drug Detection - Abstract Abstract Validation of Oral Fluid as a Matrix for Drug Detection Eva Maria Reichardt New testing procedures used as an aid for law enforcement are subject to intensive scrutiny in the courts. In recent years in workplace drug testing there has been a shift away from using traditional specimens (i.e urine) for drug testing and monitoring and a move to employing less invasive testing using oral fluid. Whilst it is now widely accepted that drugs can be detected in oral fluid and devices are now available to facilitate analysis of drugs in this matrix, our understanding of the behaviour of drugs in the mouth and oral secretions is far from complete. Since the introduction of oral fluid drug testing in the late 1990’s it has been observed that some drugs appear to be present at higher than expected concentrations, often at concentrations that would be fatal if they were in blood.
    [Show full text]
  • World Journal of Pharmaceutical Research Joshi Et Al
    World Journal of Pharmaceutical Research Joshi et al. World Journal of Pharmaceutical Research SJIF Impact Factor 6.805 Volume 5, Issue 9, 495-533. Review Article ISSN 2277– 7105 A BRIEF STUDY ON PERFORMANCE ENHANCING DRUGS (PED’S) Mohammad Ashid, Deepika Katariya, Prachi Agarwal, K.Soni and Ajit Joshi* Synthetic Organic and Medicinal Chemistry Laboratory, Department of Chemistry, Mewar University, Chittorgarh, Rajasthan, India. ABSTRACT Article Received on In present investigation, wedescribe the best Performance enhancing 11 July 2016, Revised on 02 Aug. 2016, drugs now a day‘s used by the athletes, adults, children and physically Accepted on 23 Aug. 2016 weak patients for their physical improvements. These drugs are best DOI: 10.20959/wjpr20169-6970 for medicinal purpose but from ancient time these are also used by the athletes and by some adults who want to gain the desired physical *Corresponding Author fitness for various reasons. By studying these drugs we can get the Ajit Joshi knowledge about these drugs like what are their medicinal effects and Synthetic Organic and Medicinal Chemistry what are the side effects of these drugs and how they are synthesized Laboratory, Department of and what are their physical and chemical properties. By getting Chemistry, Mewar knowledge about these drugs we can improve and synthesize new University, Chittorgarh, PED‘s with less adverse effects.Besides this it envisages specific drug Rajasthan, India. classes like stimulants,Narcotic analgesics, Anabolic-Androgenic steroids, Peptide Hormone, Diuretic, Creatine, Beta-2-Agonists etc., their unpleasant effects and structures. KEYWORDS: PED‘s, Narcotic Analgesics, Stimulants, Peptide Hormone, Diuretic. INTRODUCTION The performance enhancing substances are also included inone of the type of drug.
    [Show full text]
  • Masterarbeit
    MASTERARBEIT Titel der Masterarbeit „Radiosynthesis of the DAT-PET-Tracer [18F]FE@IPCIT“ verfasst von Cornel Fink, BSc angestrebter akademischer Grad Master of Science (MSc) Wien, 2013 Studienkennzahl lt. Studienblatt: A 066 862 Studienrichtung lt. Studienblatt: Masterstudium Chemie Betreut von: assoc. Professor Dr. Wolfgang Wadsak meinen Eltern Table of Content 1 INTRODUCTION .................................................................................................................... 1 1.1 RADIOACTIVITY ............................................................................................................................ 1 1.1.1 Radioactive Decay ............................................................................................................... 1 1.1.2 Activity ................................................................................................................................. 2 1.1.3 Half-life ................................................................................................................................ 2 1.1.4 Decay Modes ....................................................................................................................... 2 1.1.4.1 Alpha (α) Radiation ................................................................................................................... 2 1.1.4.2 Beta (β) Radiation ..................................................................................................................... 3 1.1.4.2.1 β- Decay (Electron Emission) ...............................................................................................
    [Show full text]
  • |||||||||III USOO55524.07A United States Patent (19) 11) Patent Number: 5,552,407 Wood Et Al
    |||||||||III USOO55524.07A United States Patent (19) 11) Patent Number: 5,552,407 Wood et al. 45) Date of Patent: Sep. 3, 1996 (54) ANHYDROECGONINE COMPOUNDS AND P. Jacob III et al., “A Pyrolysis Product, Anhydroecgonine THEIR USE ASANTICHOLNERGC Methyl Ester (Methylecgonidine), is in the Urine of Cocaine AGENTS Smokers' J. Anal. Toxicol. 14:353-357 (1990). W. T. Lowry et al., "Identification of Two Novel Cocaine (75) Inventors: Ronald W. Wood, Nyack; Hassan A. Metabolites in Bile by Gas Chromatography and Gas Chro N. El-Fawal, Middletown; John F. matography/Mass Spectrometry in a Case of Acute Intrave Graefe, Greenwood Lake, all of N.Y.; nous Cocaine Overdose' J. Anal. Toxicol. 3:91-95 (1979). Lung C. Chen, Upper Saddle River, Carroll et al., “Probes for the Cocaine Receptor. Potentially N.J.; Jalil Shojaie, Tuxedo, N.Y. Irreversible Ligands for the Dopamine Transporter'J. Med. Chem. 35:1813-1817 (1992). 73) Assignee: New York University Medical Center, Cereda et al., "Synthesis and Biological Evaluation of New New York, N.Y. Antimuscarinic Compounds with Amidine Basic Centers. A Useful Bioisosteric Replacement of Classical Cationic (21) Appl. No.:76,315 Heads' J. Med. Chem. 33:2108-2113 (1990). J. Sharkey et al., "Cocaine Inhibits Muscarinic Cholinergic (22 Filed: Jun. 11, 1993 Receptors in Heart and Brain' J. Pharmacol. Exp. Ther (51 Int. Cl." ......................... A61K 31/44; CO7D 213/20 246:1048-1052 (1988). 52 U.S. C. ............................ 514/291; 546/91; 54.6/132; Meyer et al., “Effects of Benzolytropine and Tropacocaine 54/304 on Several Cholinergic Processes in the Rat Brain' J.
    [Show full text]