Doxium Has Been Proven to Be the Only Oral Agent Available for Delaying the Progression of Diabetic Retinopathy. It Has Also

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Doxium has been proven to be the only oral agent available for delaying the progression of diabetic retinopathy. It has also shown benefits in chronic venous insufficiency and haemorrhoids. Product Indications Pack Size DOXIUM 500 Cases of microangiopathy including diabetic retinopathy, 30’s/box capsules. chronic venous insufficiency. As an adjuvant in the treatment of blister-pack Each cap. contains superficial thrombophlebitis, post-thrombotic syndrome, 500mg calcium oedema, stasis dermatitis, circulatory disturbances of dobesilate. arteriovenous origin or due to impaired microcirculation & haemorrhoidal syndrome. ACTIVE PRINCIPLE Calcium 2, 5 dihydroxybenzenesulfonate (Ca dobesilate, INN) PROPERTIES Doxium corrects capillary hyperpermeability and increases capillary resistance. It antagonises the effect of vasoactive substances (histamine, serotonin, bradykinin, prostaglandins and PAF), acts against collagen breakdown, reduces blood hyperviscosity, increases red cell flexibility, diminishes platelet hyperaggregation and improves lymphatic drainage. CONTRA-INDICATIONS No contra-indications known up to now. TOLERABILITY Doxium is particularly well tolerated, even when administered for long-term therapy. It is not toxic; it is practically not metabolized in the body and does not impair hepatic or renal function in any way. It has no effect on arterial blood pressure, blood coagulation or glucose and lipid metabolisms. Doxium has no teratogenic effects and does not cross the placental barrier. Like most drugs, it should not be administered during the first 3 months of pregnancy. Numerous published clinical trials, totaling over 5000 cases, show that the incidence of undesirable side effects is extremely low (3.4%). These usually involve slight digestive disorders. PRESENTATIONS DOXIUM 500, capsules containing 500mg calcium dobesilate. .

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Complete Healing of Venous Leg Ulcer Using a Collagen Based Dressing a Case Report
Case Report Journal of Surgical Techniques and Procedures Published: 30 Jul, 2018 Complete Healing of Venous Leg Ulcer Using a Collagen Based Dressing a Case Report Dumont Isabelle1#, Caillava Celine2#, Dupoiron Stephanie2, Guillemin Yannis2## and Gouze Jean Noel2*## 1Department of Foot and Ankle Surgery, Center of the Foot Ransart, Belgium 2Department of Research and Development, Genbiotech, France #Dumont Isabelle and Caillava Celine Contributed Equally to this Work ##Guillemin Yannis and Gouze Jean Noel are Co-senor Authors Abstract Venous Leg Ulceration (VLU) is a common pathology which affects patients at any age. Ulcers are characterized by long-term healing, pain and frequent recurrence despite adherence to standard of care resulting in time consuming and costly treatments. Here, the authors describe the case of a diabetic, 63 years old male suffering from venous insufficiency and presenting a distal leg ulcer. The ulcer was treated using GBT013 device, a new biocompatible and biodegradable tri-dimensional collagen based matrix. GBT013 seems to be well integrated to the healing tissues and well tolerated. No complication or pain was reported during treatment. Complete healing was obtained within 36 days with no recurrence to date despite a context of stasis dermatitis. Keywords: Venous leg ulcer; Collagen dressing; Tri-dimensional matrix; Wound healing Abbreviations DFU: Diabetic Foot Ulcer; VLU: Venous Leg Ulcer Introduction Venous Leg Ulcers (VLUs) are open lesions of the lower extremities caused by venous disease. OPEN ACCESS Risk factors include all factors susceptible to increase pressure within vessels (e.g., obesity, immobility, thrombosis, varicose veins, and trauma) [1-3]. They are more common in women *Correspondence: and older people and represent 60% to 80% of leg ulcers [4-7].
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