Mouse Anti-Ferritin Heavy Chain Monoclonal Antibody, Clone 4G9 (DCABH-5700) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Mouse anti-Ferritin Heavy Chain Monoclonal antibody, clone 4G9 (DCABH-5700) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Mouse monoclonal to Ferritin Heavy Chain - BSA and Azide free

Antigen Description Ferritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis by sequestering and storing iron in a non-toxic and soluble form. It forms a holoenzyme of ~450 kDa, consisting of 24 subunits of two types, H (heavy; 21 kDa) and L (light; 19 kDa), and is capable of storing up to 4,500 atoms of ferric iron. Depending on the tissue type and physiological status of the cell, the ratio of H to L subunits in ferritin can vary widely. Ferritin is found in the liver, spleen, kidney and heart, with smaller amounts being found in blood. Serum ferritin levels serve as an indicator of the amount of iron stored in the body. Serum ferritin is the most sensitive test for anaemia, and is also used as a marker for restless leg syndrome, hemochromatosis and porphyria. As ferritin is an acute-phase reactant, it is often elevated during infection. Defects in ferritin proteins are associated with several neurodegenerative diseases.

Isotype IgG2a

Source/Host Mouse

Species Reactivity Human

Clone 4G9

Conjugate Unconjugated

Applications WB

Format Liquid

Size 1 mg

Buffer Constituent: PBS

Preservative None

Storage Store at -20°C. Avoid freeze / thaw cycle.

Ship Shipped at 4°C.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Gene Name FTH1 ferritin, heavy polypeptide 1 [ Homo sapiens ]

Official Symbol FTH1

Synonyms FTH1; ferritin, heavy polypeptide 1; FTHL6; ferritin heavy chain; apoferritin; FHC; FTH; PIG15; placenta immunoregulatory factor; PLIF; proliferation inducing protein 15; ferritin H subunit; proliferation-inducing protein 15; cell proliferation-inducing g

Entrez Gene ID 2495

Protein Refseq NP_002023

UniProt ID A0A024R525

Chromosome Location 11q13

Pathway Clathrin derived vesicle budding, organism-specific biosystem; Golgi Associated Vesicle Biogenesis, organism-specific biosystem; Iron uptake and transport, organism-specific biosystem; Membrane Trafficking, organism-specific biosystem; Mineral absorption, organism- specific biosystem; Mineral absorption, conserved biosystem; Porphyrin and chlorophyll metabolism, organism-specific biosystem;

Function ferric iron binding; ferroxidase activity; iron ion binding; oxidoreductase activity; protein binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]