Twinfilin regulates breast cancer cell invasion and interleukin-11 expression through the miR-206/ MKL1/SRF pathway

Ravand Samaeekia1*, Valery Adorno-Cruz 2,3*, Jessica Bockhorn1,4*, Ya-Fang Chang1*, Simo

Huang3, Aleix Prat5,6, Nahun Ha3, Golam Kibria3, Dezheng Huo7, Hui Zheng8 , Rachel Dalton1,

Yuhao Wang1, Grigoriy Y. Moskalenko1, Huiping Liu3,9,10#

I. Supplemental Materials and Methods

II. Supplemental Figures 1-4 and Legends

III. Supplemental Tables 1-2

I. Supplemental materials and methods

F-actin quantification: The experiments were conducted according to manufacturer's instructions

(Cytoskeleton, Denver, CO, USA). Briefly, equal number of cells from each treatment condition were lysed in 100ul of lysis buffer and incubated at 37°C for 10 min. Lysates were centrifuged at 350 x g, room temperature for 5 minutes to pellet unbroken cells of tissue debris. Supernatants were ultra- centrifuged at 100,000 x g, 37°C for 1h. This step pelleted F-actin and left G-actin in the supernatant.

100 µl of F-actin depolymerization buffer was added to each pellet and incubate on ice for 1h to allow actin depolymerization to occur. Eventually, each of the pellet and supernatant samples was mixed with 25 µl of 5X SDS sample buffer, and F/G actin content was quantified by SDS-PAGE and western blot analysis.

Immunofluorescence staining and microscopy: 80,000 of cells were seeded into chambers of a 4 well chamber microscope slide (Millipore). Cells were fixed in 4% paraformaldehyde for 15 minutes, permeabilized in 0.1% Triton X-100 in PBS, and blocked for 30 minutes in 1% bovine serum albumin (BSA). Cells were stained with fluorescent phalloidin (Invitrogen) or anti- vinculin (ab18058; Abcam, Cambridge, UK) and set with SlowFade Gold antifade reagent with

DAPI (Invitrogen). Secondary anti-mouse Texas Red (T-862-invitrogen) was used for vinculin staining. Cell images were taken using Olympus spinning disc confocal microscope. Focal adhesions were quantified using ImageJ software with 50 cells counted per well. Mouse entire lung images were taken using Leica SP5 Tandem Scanner Spectral 2-Photon Confocal microscope (Leica).

Gelatin invadopodia assay: In accordance to manufacturer's instructions (Millipore QCM kit), 4- well slides (Millipore) were incubated in Poly-L-Lysine solution at room temperature for 20 minutes. They were washed with PBS (3 × 5 min) and immediately crosslinked with ice-cold

0.8% glutaraldehyde for 15 minutes. After three washes with PBS they were gelatin-coated with

1:5 mixture of Fluorescein-Gelatin: Unlabeled Gelatin for 10 minutes. Slides were successively washed in PBS (3 × 5 min), and disinfected in 70% ethanol for 30 minutes, before quenching for

30 minutes with DMEM. Cells were cultured for 24 hr and the slides were subsequently analysed using fluorescence microscopy procedures outlined earlier.

Sub-G1 apoptotic population analysis: 250K MDA-MB-231 cells were plated in 12-well plates and transfected as described above. Both adherent and floated cells were collected at 24hrs or 72hrs and fixed in 70% ethanol. Cells were then stained with propidium iodide (Sigma, St.

Louis, MO) and DNA content was analyzed using BD LSRII flow cytometer (BD Biosciences).

Luciferase assay: Approximately 30K HEK293t cells were seeded onto 96-well plates. Cells were subsequently transfected with either miR-206 or scramble as described earlier, followed by overnight transfection with 3’UTR of either TWF1, NOTCH, or G6PD (Switchgear Genomics,

Carlsbad, CA, USA) using Fugene HD (Promega). Luciferase activity was assessed using

LightSwitch Assay System kit (Switchgear Genomics) and plate scanner (Perkin-Elmer,

Waltham, MA, USA).

Bioluminescence imaging: Mice were anesthetized with isofluorane and injected intraperitoneally with 100 uL of D-luciferin (Biosynth AG, Switzerland) at 30 mg/ml per mouse.

After ten minutes, the entire bodies of the animals were imaged using IVIS Spectrum system

(Caliper Life Sciences, USA). Only the signals from the lung (chest area) were recorded. Time exposure ranged from 1 second to 5 minutes depending on light intensity. Data was analyzed using LivingImage 4.0 Software (Caliper Life Sciences) and expressed as total photon flux.

Gene expression and microRNA correlation: Gene expression and microRNA expression data were obtained from breast cancer database METABRIC (1, 2). Quantification of known and putative microRNAs was performed using Agilent microarrays. Message RNA transcripts were quantified using Illumina HT-12 v3 platform. We examined the correlation between expression of miR-206 and expression of several genes, including TWF1 using Pearson’s correlation coefficient. Outliners in miR-206 were excluded and the analysis was conducted in all 1300 subjects and within intrinsic subtypes based on PAM50 signature.

References 1. Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, et al. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature. 2012;486:346-52. 2. Dvinge H, Git A, Graf S, Salmon-Divon M, Curtis C, Sottoriva A, et al. The shaping and functional consequences of the microRNA landscape in breast cancer. Nature. 2013;497:378-82.

II. Supplemental Figures and legends Supplementary Figure 1 A miR control miR-206

B miR control miR-206

A 20.6% 53.8%

- SSC

Annexin-V-PE

C

miR-control miR-206 80 *

Control 70

60 50

40 Count

30

Percentage cells ** 20 206 * - ** 10

0 miR apoptosis G0/G1 S G2/M

DNA Content (PI) Supplementary Figure 1: miR-206 arrests cell cycle and induces apoptosis in ER positive breast cancer cells. A. MCF-7 cell morphology at 48 hours post transfection with control and miR-206 (round and detaching cells). B. Annexin V-PE staining shows increased cell death in MCF-7 cells (floating and adherent cells) at 48 hours post transfection. C. PI Cell cycle analysis of MCF-7 cells (adherent cells) at 48 hour post transfection. P values: 0.007045 (sub-G1 indicated apoptosis, **p<0.01), 0.014278 (G1, *p<0.05), 0.050552 (S, *p=<0.05), 0.008066 (G2/M, **p<0.01).

Supplementary Figure 2 C A B MDA-MB-231 1.4 BT-20 1.2 1.2

HS578T 1.2

1 1

1 * * * * 0.8 * 0.8 0.8

Invasion 0.6 0.6 0.6 *

0.4 0.4 0.4 Relative Invasion Invasion Relative 0.2 Relative 0.2 Growth Fluorescence Growth 0.2 0 0 0

D HS578T E F HS578T 1.4 250000 MDA-MB-231 250000 Scr 1.2 Scr miR-206 200000 miR-206

1 200000 TWF1 KD

TWF1 KD IL11 KD ** 0.8 150000 ** IL11 KD ** 150000 0.6 100000 *** growth Fluorescence growth 0.4 100000

Cell Cell Number *** Cell Cell Number 0.2 50000 50000 * Relative Relative 0 0 Day 0 Day 1 Day 2 Day 3 0 Day 0 Day 1 Day 2 Day 3

G H 1.2 MDA-MB-231 MCF7

1

Scr miR-206 0.8

0.6 ** **

0.4 Cell Cell Counts Relative Migration Relative 0.2

0

DNA Content (PI) Supplementary Figure 2. A. Transwell invasion assays of BT-20 cells transfected with miR-206 showed inhibition as compared to scramble controls. * p<0.05 B. Transwell invasion assays of HS578T cells transfected with miR-206, TWF1KD, MKL1KD, SRFKD, IL-11 KD or scramble control showed inhibition as compared to scramble controls. * p<0.05 C. Calcein AM Fluorescence of transfected MDA-MB-231 cells plated concurrently with transwell invasion assays, showed no significant difference in cell signals 48 h post transfection. D. Calcein AM Fluorescence Fluorescence of HS578T cells plated concurrently with transwell invasion assays, showed no significant difference in cell signals 48 h post transfection. E. Cell counts of MDA-MB-231 cells transfected with miR-206, TWF1KD, IL-11 KD compared to the scramble control showing significant reduction of cell number by miR- 206 (red line) or IL-11 knockdown (purple line) after Day 3. ** p<0.01 F. Cell counts of HS578T cells transfected with miR-206, TWF1KD, IL-11 KD compared to the scramble control. * p<0.05, **p<0.01, ***p<0.001. G. Representative flow profiles on DNA content of MDA-MB-231cells at 24 hours post transfection of miR-206 or scramble control with minimal cell cycle difference between two groups. H. Relative migration of MCF7 cells transfected with either miR-206, TWF1 siRNA or scramble control. **p<0.01

Supplementary Figure 3

1.2 A HS578T B

1 Change 0.8 * 50 kD 0.6 37 kD G-actin 0.4

0.2 MKL1 mRNA Fold MKL1mRNA 0 Scr TWF1 KD G-actin Depolymerized F-actin C D 1.2 HS578T 9 HS578T **** 8 1 7 0.8 * * 6

* Chnage 0.6 5 **** 4 0.4 **** 3 0.2 **

11 mRNA (Fold Change) (Fold mRNA 11 **

- 2

IL 0 1

11 mRNA Fold mRNA 11 -

0 IL No CD 30 min 1 Hour 2 Hour 4 Hour 6 Hour CD CD CD CD CD E 1.2 MCF7

1

* * 0.8

TWF1 Change 0.6 MKL1 ** ** ** SRF

0.4 IL11 mRNA Fold Fold mRNA **** 0.2 ****

0 Scr miR-206 TWF1 KD Supplementary Figure 3. Gene analyses by PCR and migration A. Realtime PCR of MKL1 expression in HS578T cells transfected with either TWF1 siRNA or scramble control. *p<0.05 B. miR-206 and TWF1 regulate G-actin/F-actin ratio. Western blot using G-actin antibody from ultracentrifugation separating F- and G-actin. F-actin was depolymerized before western blot. C. Realtime PCR of IL-11 expression in HS578T cells transfected with miR-206, siTWF1, siMKL1, siSRF, or scramble control. *p<0.05 D. Realtime PCR of IL-11 expression in HS578T cells treated with Cytochalasin D (CD) from 30 minutes to 6 hours. **p<0.01, ****p<0.00001 E. Realtime PCR of TWF1, MKL1, SRF and IL-11 expression in MCF7 cells transfected with either miR-206 or TWF1 siRNA compared to the scramble control. *p<0.05, **p<0.01, ****p<0.00001

Supplementary Figure 4 Effects of miR-206/siIL11 on CD44 of TN1 PDX

A

miR control miR-206

Count

CD44-FITC

B siRNA-Con siIL-11

Count

CD44-FITC Supplementary Figure 4. Effects of miR-206/siIL11 on CD44 of PDX A. miR-206 reduced CD44 expression of primary tumor cells (TN1-PDX) at 48 hours post transfection. B. IL-11 siRNA-mediated knockdown decreased CD44 expression in TN1 breast tumor cells of PDXs at 48 hours post transfection.

III. Supplemental Tables 1-2

Supplementary Table 1 Microarray results showing genes down-regulated when miR-206 is overexpressed in MDA-MB-231 cell lines. Three replicate samples of miR-206 overexpression were compared to three replicates of scramble control and three replicates of mock transfections. Supplementary Table 2 Weak, inverse correlations were observed between expression of miR-206 and expression of TWF1 in all 1300 breast cancer patients and in 354 patients with the luminal A subtype of breast cancer.

Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 5756 TWF1 ‐2.555 ‐2.45 ‐2.605 0.44 0 ‐0.065 0.355 0.02 0.21 1.32269E‐07 ‐2.696666667 8407 TAGLN2 ‐2.105 ‐2.18167 ‐3.00833 0.2583333 0.1183333 0.60166667 0.078333 0.201667 ‐0.18833 1.38349E‐05 ‐2.61 7117 TMSL3 ‐1.7 ‐1.33 ‐2.89 ‐0.26 0.61 0.385 0 0.625 0.465 0.000504015 ‐2.2775 440085 LOC440085 ‐2.51 ‐1.75 ‐1.98 ‐0.12 0.57 0.28 ‐0.41 0.54 0.05 7.99472E‐05 ‐2.231666667 23446 SLC44A1 ‐2.005 ‐2.07 ‐1.88 0.54 0.57 0.075 ‐0.29 ‐0.55 ‐0.595 0.000440919 ‐1.943333333 8683 SFRS9 ‐2.22 ‐1.8825 ‐1.6 0.0125 ‐0.0375 0.175 ‐0.1125 0.01 0.1 1.70172E‐06 ‐1.925416667 79728 PALB2 ‐1.69 ‐3.58 ‐0.41 0.39 0.05 ‐1.22 0.84 0.2 ‐0.11 0.034217384 ‐1.918333333 3927 LASP1 ‐1.33 ‐1.66 ‐2.28333 0.66 ‐0.22 0.21333333 0.286667 0.013333 0 0.00014445 ‐1.916666667 10487 CAP1 ‐1.33 ‐1.615 ‐2.255 0.26 ‐0.075 0.065 0.52 ‐0.09 0.03 8.05744E‐05 ‐1.851666667 3884 KRT33B ‐0.664 ‐2.76 ‐1.25714 0.1066667 ‐0.6 0.47 0 0.01 1.35 0.01587874 ‐1.78315873 79850 FAM57A ‐1.48 ‐2.08 ‐1.14 0.51 0.14 0.06 0.38 0 ‐0.1 0.000126608 ‐1.731666667 643 CXCR5 ‐3.26 ‐0.3525 ‐1.01 0.1 0.255 0.125 ‐0.02 0.64 0 0.022983474 ‐1.724166667 201895 C4orf34 ‐1.2 ‐2.1 ‐1.36 ‐0.15 0.41 0 0.18 0.31 0.25 0.00010474 ‐1.72 55908 LOC55908 ‐0.34611 ‐2.63 ‐1.31 0.17 0.78 ‐0.39 0.46 0.43 0.12 0.011124727 ‐1.69037037 378 ARF4 ‐1 ‐1.62 ‐2.11 0.21 0 ‐0.14 0.41 ‐0.15 0.28 0.00028833 ‐1.678333333 51157 ZNF580 ‐1.6 0 ‐1.66 ‐0.27 1.06 1.37 ‐0.75 0.85 0.83 0.034371524 ‐1.601666667 5757 PTMA ‐1.67233 ‐1.569 ‐1.13733 0.322 0.1243333 0.126 0.104333 0.106 0 4.12515E‐06 ‐1.59 558 AXL ‐0.61 ‐1.2 ‐2.28 0.73 0.03 0 0.92 ‐0.18 ‐0.17 0.007742675 ‐1.585 339122 RAB43 ‐1.77 ‐1.535 ‐1.33 ‐0.3533333 ‐0.0333333 0.0275 0 0.156667 0.365 2.8374E‐05 ‐1.572083334 5547 PRCP ‐1.35 ‐0.98 ‐1.8 0.03 0.54 0.24 ‐0.13 0.21 0.21 0.000126918 ‐1.56 64420 SUSD1 ‐1.63 ‐1.28 ‐1.82 ‐0.52 0.12 0.17 0.22 0 ‐0.1 8.52207E‐05 ‐1.558333333 956 ENTPD3 ‐0.27 ‐0.54 ‐2.27 0.96 0.97 0.95 ‐0.25 0.43 0.09725 0.019544824 ‐1.552875 7114 TMSB4X ‐0.645 ‐0.165 ‐2.42 ‐0.24 1.25 0.52 ‐0.28 0.455 1.15 0.035026594 ‐1.5525 4580 MTX1 ‐1.66 ‐1.41 ‐1.43 ‐0.04 0.12 0.18 ‐0.16 0.13 ‐0.12 1.3538E‐06 ‐1.518333333 7852 CXCR4 ‐2.04 ‐0.53 ‐1.8 0.09 0.61 0.5 ‐1.01 0 0.15 0.013386674 ‐1.513333333 23531 MMD ‐1.52 ‐1.27 ‐1.09 ‐0.06 0.72 0.66 ‐0.33 ‐0.11 0.4 0.000927291 ‐1.506666667 114801 TMEM200A ‐1.79 ‐0.955 ‐1.31 0.12 0.33 0 0.045 0.4 0.01 9.49166E‐05 ‐1.5025 302 ANXA2 ‐0.7225 ‐0.9575 ‐2.26667 0.38 0.27 0.315 0.2825 0.093333 ‐0.2475 0.003311248 ‐1.497777778 3021 H3F3B ‐1.38 ‐1.284 ‐1.25 0.13 ‐0.056 0.272 0.294 0.202 0.154 3.37711E‐07 ‐1.470666667 4201 MEA1 ‐0.84 ‐0.45 ‐1.37 0 0.57 1 0.41 0.62 0.78 0.001004928 ‐1.45 285641 SLC36A3 ‐2.6 ‐0.25375 ‐1.38 ‐0.75 0.02 0.65 0.52 ‐0.4 0.16 0.033374516 ‐1.444583333 399665 FAM102A ‐1.32 ‐1.3 ‐1.55 ‐0.22 ‐0.23 ‐0.08 0.005 0.31 0.38 5.82286E‐05 ‐1.4175 7078 TIMP3 ‐0.912 ‐0.75 ‐1.932 0.06 0.386 0.168 0 0.33 0.284 0.000995239 ‐1.402666667 51497 TH1L ‐0.56333 ‐1.34667 ‐1.49 0.83 0 0.14666667 0.796667 ‐0.03333 ‐0.13 0.003204321 ‐1.401666667 25793 FBXO7 ‐1.36 ‐0.76 ‐1.24 0 0.39 0.5 0.67 0.26 ‐0.14 0.000366411 ‐1.4 5479 PPIB ‐0.665 ‐1.45 ‐1.39 0.58 0 ‐0.125 1.08 0.105 ‐0.255 0.004764313 ‐1.399166667 64333 ARHGAP9 ‐0.93 ‐1 ‐0.99 0.3 0.36 0.65 1.09 0 0.0701 0.000721007 ‐1.385016667 8352 HIST1H3C ‐1.71 ‐1.23 ‐1.4 0.02 ‐0.19 0 ‐0.27 0.05 0 8.87273E‐06 ‐1.381666667 54502 RBM47 ‐0.79333 ‐0.91167 ‐1.89167 ‐0.3633333 0.2666667 0.09 ‐0.12667 0.516667 0.633333 0.00378452 ‐1.368333334 65124 ANKRD57 ‐1.21 ‐1.75 ‐1.31 ‐0.03 ‐0.4 ‐0.08 0.03 0.13 0 4.60662E‐05 ‐1.365 54551 MAGEL2 ‐1.85 ‐2.01 ‐0.13 ‐0.15 ‐0.01 0 0.23 0.07 0.06 0.011432363 ‐1.363333333 4233 MET ‐0.806 ‐1.05 ‐1.89733 0.328 0.082 0.022 0.104 0.068 0 0.000577135 ‐1.351777778 55276 PGM2 ‐1.39 ‐1.39 ‐1.09 ‐0.34 0.14 ‐0.01 0.17 0.12 0.29 3.60509E‐05 ‐1.351666667 7106 TSPAN4 ‐0.57 ‐0.83333 ‐1.92 0.19 0.17 0.40666667 0.463333 0.04 0.176667 0.002209267 ‐1.348888889 5478 PPIA ‐1.63 ‐0.8 ‐1.51 ‐0.28 0.17 0.08 0.15 0.04 0 0.000242349 ‐1.34 11153 FICD ‐0.48 ‐0.62 ‐2.71 0.1 0 0.06 ‐0.33 0.28 0.3 0.029657171 ‐1.338333333 50515 CHST11 ‐1.06 ‐0.935 ‐1.88 ‐0.215 0 0.01 ‐0.025 0.25 0.23 0.000513625 ‐1.333333333 9951 HS3ST4 ‐0.435 ‐1.825 ‐0.92 0.755 ‐0.505 ‐0.29 0.945 0 0.595 0.021665776 ‐1.31 78990 OTUB2 ‐1.775 0 ‐1.74 ‐0.14 0.32 0.70333333 ‐0.8 0.583333 0.063333 0.037525515 ‐1.293333333 1687 DFNA5 ‐0.29 ‐0.87 ‐1.39 0.92 0.4 0.66 0.71 0 ‐0.05 0.004630015 ‐1.29 10541 ANP32B ‐0.95 ‐0.98 ‐1.35 0.95 0.03 0.22 0.65 ‐0.19 ‐0.51 0.006189737 ‐1.285 4494 MT1F ‐1.09 ‐0.825 ‐0.955 ‐0.075 0.565 0.485 0 0.595 0.355 0.000199575 ‐1.2775 57645 POGK ‐1.225 ‐1.16 ‐1.09 0 ‐0.08 ‐0.02 0.51 0.16 0.105 2.48774E‐05 ‐1.270833333 8355 HIST1H3G ‐1.45 ‐0.84 ‐1.28 ‐0.16 ‐0.02 0.31 0 0.07 0.11 7.80449E‐05 ‐1.241666667 440193 CCDC88C ‐0.63925 ‐1.06 ‐2.05 0.58 ‐0.41 0 0.04 ‐0.62 0.35 0.014436521 ‐1.23975 200931 OSTalpha ‐0.795 ‐0.26 ‐0.95643 0.275625 0.835 1.105 ‐0.205 0.6 0.805 0.005395969 ‐1.239747024 23370 ARHGEF18 ‐0.98 ‐1.03 ‐1.66 ‐0.17 0 ‐0.13 0.21 0.14 0 0.000159974 ‐1.231666667 126961 HIST2H3C ‐1.425 ‐0.835 ‐1.12 ‐0.035 0 0.4 ‐0.215 0.39 0.085 0.000283472 ‐1.230833333 54815 GATAD2A ‐1.32 ‐0.48 ‐0.94 ‐0.13 0.45 0.44 0.08 0.59 0.46 0.001062631 ‐1.228333333 11167 FSTL1 ‐1.11 ‐0.88 ‐1.32 0.7 0.49 0.13 ‐0.05 ‐0.3 ‐0.22 0.00181639 ‐1.228333333 164022 PPIAL4A ‐1.12667 ‐0.80333 ‐1.10333 ‐0.05 0.1666667 0.39333333 0.526667 0.26 1.39E‐17 7.8781E‐05 ‐1.227222222 4688 NCF2 ‐1 ‐0.33 ‐1.5 ‐0.71 0.37 0.55 0.09 0.83 0.56 0.016999949 ‐1.225 201799 TMEM154 ‐0.065 ‐0.495 ‐0.765 0.705 0.5 0.685 0.055 1.78 0.955 0.012809871 ‐1.221666667 3673 ITGA2 ‐0.64 0.22 ‐1.85 0.2966667 1.1033333 0.73666667 ‐0.26667 0.896667 0 0.047601069 ‐1.217777778 50486 G0S2 ‐0.76 0.05 ‐2.37 ‐0.29 0.21 0.21 0.15 0.64 0.19 0.045169262 ‐1.211666667 9289 GPR56 ‐0.16 ‐0.565 ‐1.785 0.595 0.575 0.29 0.615 0.17 0 0.011313218 ‐1.210833333 7086 TKT ‐0.48 ‐0.93 ‐1.42 0.54 ‐0.09 ‐0.01 0.95 0.16 0.03 0.004992328 ‐1.206666667 286006 C7orf53 ‐1.83 ‐0.9 ‐0.19 ‐0.03875 0.75 0.33 0.1 ‐0.44 0.69 0.022298787 ‐1.205208333 5272 SERPINB9 ‐0.80333 ‐1.24333 ‐1.50333 0.16 0.1766667 ‐0.27 0.015 0.12 ‐0.08667 0.000191346 ‐1.2025 85365 ALG2 ‐0.99 ‐1.23 ‐1.32 ‐0.27 0 ‐0.18 0.04 0.19 0.35 9.584E‐05 ‐1.201666667 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 5271 SERPINB8 ‐0.71 ‐0.17 ‐2.225 ‐0.41 0 0.45 0.07 0.545 0.315 0.033610044 ‐1.196666667 8877 SPHK1 ‐1.38 ‐0.3 ‐0.93 ‐0.46 ‐0.03 0.78 0.19 0.74 0.72 0.014004499 ‐1.193333333 54843 SYTL2 ‐0.76 ‐0.48 ‐2.3 0.065 0.005 0.06 0.55 ‐0.885 0.245 0.039095916 ‐1.186666667 7057 THBS1 ‐0.88 ‐0.37 ‐1.745 0.7 0.4766667 0.37 ‐0.485 ‐0.18 0.206667 0.015607652 ‐1.179722222 55775 TDP1 ‐1.2 ‐1.31 ‐0.96 0.07 0.08 ‐0.04 ‐0.05 ‐0.02 0.09 1.33744E‐06 ‐1.178333333 4942 OAT ‐0.83 ‐1.56 ‐0.53 0.96 0 0.17 0.68 ‐0.53 ‐0.08 0.017620798 ‐1.173333333 10971 YWHAQ ‐1.156 ‐1.028 ‐1.15667 ‐0.1 0.114 ‐0.0925 0.368333 0.04 0.022 1.15377E‐05 ‐1.172194445 5796 PTPRK ‐1.135 ‐0.6775 ‐1.295 0 0.18 ‐0.04 ‐0.175 0.5175 0.33 0.000552108 ‐1.17125 2539 G6PD 0 ‐0.19 ‐0.74 0.05 2.22 0.58 0.9 0.71 0.67 0.038526886 ‐1.165 84747 UNC119B ‐1.17 ‐1.25 ‐0.79 0.47 0.05 0.09 0 0 ‐0.06 0.000101666 ‐1.161666667 2706 GJB2 ‐1.37333 ‐0.385 ‐0.95667 0 0.6133333 0.13666667 ‐0.53667 0.19 1.126667 0.019890488 ‐1.16 84650 EBPL ‐2.065 ‐1.11 ‐0.19 ‐0.05 0.22 0 ‐0.32 0.36 ‐0.005 0.019049247 ‐1.155833333 80195 C10orf57 ‐1.295 ‐1.265 ‐1.065 0.075 ‐0.115 ‐0.055 0.005 0 ‐0.23 1.78143E‐06 ‐1.155 283159 OR8D1 0 ‐1.34 ‐1.66429 ‐0.04 0.85 ‐0.14 ‐0.06 0.03 0.274375 0.023519709 ‐1.153824405 6916 TBXAS1 ‐1.59 ‐0.37333 ‐0.525 0.105 0.3 0.37333333 0 0.846667 0.295 0.007083903 ‐1.149444444 56262 LRRC8A ‐0.88 ‐1.105 ‐1.145 ‐0.01 0.43 ‐0.22 0.01 0.265 0.145 0.000105914 ‐1.146666667 4853 NOTCH2 ‐0.95 ‐1.2 ‐0.82 0.03 0.35 ‐0.33 0.1 0.41 0.36 0.000438067 ‐1.143333333 7097 TLR2 ‐0.47 ‐0.22 ‐1.54 0.37 0.4 0.9 ‐0.61 0.81 0.51 0.029176511 ‐1.14 89927 C16orf45 ‐0.16 ‐0.215 ‐2.095 0.255 0.13 0.295 0.43 0.2 0.555 0.032570724 ‐1.134166667 182 JAG1 ‐0.99 0.16 ‐1.375 ‐0.13 0.535 0.54 ‐0.025 0.775 0.675 0.020044711 ‐1.13 200316 APOBEC3F 0.05 ‐0.99 ‐2.13 0.1891111 0 0.51 0.37 0 ‐0.44 0.043298209 ‐1.128185185 57863 CADM3 ‐0.47813 ‐1.52813 ‐1.36146 ‐0.678125 0.471875 0 ‐0.38813 0.107875 0.511875 0.015214129 ‐1.126798611 25803 SPDEF ‐0.415 ‐0.25 ‐1.67 0.635 ‐0.135 0.525 0.485 0.225 0.31 0.012716479 ‐1.119166667 10483 SEC23B ‐0.8 ‐1.09333 ‐0.94667 0.4766667 ‐0.0866667 0.23666667 0.403333 ‐0.00333 0 0.000151404 ‐1.117777778 29998 GLTSCR1 ‐0.535 ‐1.585 ‐1.335 ‐0.025 0 0.085 ‐0.365 0.09 0 0.001870955 ‐1.115833333 55041 PLEKHB2 ‐0.78 ‐0.99 ‐1.63 0.31 ‐0.3433333 ‐0.15333333 0.036667 0.053333 ‐0.02667 0.001202265 ‐1.112777778 63935 PCIF1 ‐0.39 ‐0.86 ‐1.77 0.05 ‐0.04 0.28 0.08 0.22 0.031667 0.004944623 ‐1.110277778 6348 CCL3 ‐0.025 ‐0.64 ‐1.15528 ‐0.5 0.14 0.95 0.23 1.19 0.97 0.041406266 ‐1.103425926 7408 VASP ‐1.13 ‐0.46 ‐1.67 ‐0.81 0.3 0.16 ‐0.76 0.63 0.53 0.04311755 ‐1.095 23603 CORO1C ‐0.86 ‐1.035 ‐1.19 0.2075 ‐0.2625 0.0575 0.52 ‐0.21 0 0.000593948 ‐1.080416667 374897 SBSN ‐1.14 ‐0.194 ‐1.48889 ‐0.14 0.57 0.51 ‐0.65 0.360833 0.18 0.023794075 ‐1.079435185 30818 KCNIP3 ‐0.85 ‐1.13 ‐0.83 0.11 0 0.05 0.34 0.38 ‐0.08 6.99641E‐05 ‐1.07 8388 OR1E2 0 ‐1.36 ‐1.03 1.06 ‐0.14 0.08357143 0.13 ‐0.09286 0.58 0.027809388 ‐1.066785714 5681 PSKH1 ‐0.21 ‐1.16167 ‐1.32167 0.3066667 0 ‐0.02666667 0.44 0.323333 ‐0.04167 0.00464374 ‐1.064722222 22856 CHSY1 ‐1.28 ‐1.08 ‐0.71 ‐0.38 0.07 0.05 ‐0.09 0.23 0.34 0.000750836 ‐1.06 7170 TPM3 ‐0.69333 ‐1.35 ‐0.85167 0.7933333 ‐0.1266667 0.15366667 0.52 ‐0.48833 ‐0.29833 0.013404147 ‐1.057277778 55293 UEVLD 0 ‐1.315 ‐0.775 1.15 0.085 0.06 0.995 ‐0.12 ‐0.015 0.039219276 ‐1.055833333 55179 FAIM ‐1.39 ‐1.18 ‐0.27 0.27 0 ‐0.15 0.13 0.23 0.1 0.003610049 ‐1.043333333 27230 SERP1 ‐1.04333 ‐1.13333 ‐1.09667 ‐0.1866667 0.0633333 0.40333333 0 ‐0.51667 ‐0.08333 0.000727802 ‐1.037777778 3386 ICAM4 ‐2.195 ‐0.865 ‐0.045 ‐0.075 ‐0.065 0.29 ‐0.065 ‐0.075 0.005 0.042466536 ‐1.0375 27010 TPK1 ‐0.98 ‐0.9 ‐1.08 ‐0.12 ‐0.36 0 0.24 0.22 0.31 0.000315451 ‐1.035 56848 SPHK2 ‐0.91 ‐1.11 ‐0.97 0.04 ‐0.13 ‐0.07 0.44 ‐0.08 0 9.852E‐05 ‐1.03 79363 C1orf89 0.03 ‐1.47 ‐1.19438 ‐0.04 0.8 0 0.05 0.58 ‐0.5 0.041418469 ‐1.026458333 6591 SNAI2 ‐0.745 ‐0.43 ‐1.225 0.315 0.2 0.085 0 0.37 0.355 0.000680109 ‐1.020833333 4323 MMP14 ‐0.405 ‐0.0775 ‐1.7975 0 0.3225 0.3975 0.2675 0.105 0.4725 0.025582789 ‐1.020833333 7041 TGFB1I1 ‐0.52 ‐0.98 ‐0.99 ‐0.02 0.37 0.22 0.13 0.37 0.02 0.000197605 ‐1.011666667 1848 DUSP6 ‐0.215 ‐0.155 ‐1.985 0.24 0.065 0.265 0.075 0.345 0.37 0.039512038 ‐1.011666667 103 ADAR ‐1.35 ‐0.89833 ‐0.83333 ‐0.39 ‐0.1283333 0.18333333 0.113333 0.016667 0.11 0.000488889 ‐1.011388889 3176 HNMT ‐0.26 ‐0.83 ‐1.48 0.85 ‐0.05 ‐0.05 0.19 ‐0.15 0.13 0.015367872 ‐1.01 4860 PNP ‐1.285 ‐0.88 ‐0.53 ‐0.07 0.16 0.285 0 0.44 ‐0.15 0.001338515 ‐1.009166667 140809 SRXN1 ‐1 ‐0.86 ‐1.07667 0.08 ‐0.2833333 ‐0.02666667 0.403333 0.006667 0 0.00016554 ‐1.008888889 50853 VILL 6.94E‐18 ‐1.26 ‐1.39 ‐0.16 0.15 0.05 0.59 0.09 0 0.01816984 ‐1.003333333 54844 C6orf61 ‐2.065 ‐0.385 ‐0.305 0.195 ‐0.115 0 0.045 ‐0.13 0.515 0.041410224 ‐1.003333333 90853 SPOCD1 ‐0.71667 ‐0.53333 ‐1.36667 ‐0.13 0.1233333 0.03 0 0.48 0.263333 0.002063302 ‐1 1618 DAZL ‐0.67556 ‐0.11556 ‐1.13356 ‐0.2955556 0.1844444 0.07730159 1.294444 0.194444 0.694444 0.035509388 ‐0.999809524 27037 TRMT2A ‐0.45458 ‐0.52417 ‐1.26229 0.0858333 0.3158333 0.81583333 0 0.150278 0.141574 0.004656699 ‐0.998572531 5226 PGD ‐0.64 ‐0.815 ‐0.725 0.87 ‐0.23 0.2 0.925 0 ‐0.14 0.013615088 ‐0.9975 6598 SMARCB1 ‐0.995 ‐0.715 ‐0.955 0.42 ‐0.445 0.01 0.675 ‐0.035 0.01 0.00438859 ‐0.994166667 64857 PLEKHG2 ‐0.84 ‐1.16 ‐0.36 0.54 0.45 ‐0.1 0.26 0.04 0.05 0.002391589 ‐0.993333333 119395 CALHM3 ‐0.72 ‐0.17 ‐1.00643 0.04 1.02 0.88 0.218889 0 0 0.017729 ‐0.991957672 6347 CCL2 ‐0.365 ‐0.51 ‐1.435 ‐0.045 0.325 0.42 0 0.22 0.395 0.005471066 ‐0.989166667 84327 ZBED3 ‐1.19 ‐0.66 ‐0.94 0.22 0.08 ‐0.07 ‐0.03 0.15 0 7.77096E‐05 ‐0.988333333 27350 APOBEC3C ‐1.66 ‐0.96 ‐0.62 ‐0.58 0.34 0.07 ‐0.62 0.24 0 0.017002282 ‐0.988333333 282973 JAKMIP3 ‐0.27167 ‐0.41167 ‐1.04833 0.2083333 1.0683333 0.15119048 0 0.309333 0.708333 0.010916011 ‐0.984809524 2185 PTK2B ‐1.035 0 ‐1.725 ‐0.165 0.115 0.155 ‐0.085 ‐0.115 0.465 0.02856737 ‐0.981666667 8943 AP3D1 ‐1.18 ‐0.72 ‐1.13 ‐0.45 0.55 0 ‐0.57 0.26 0.03 0.008398007 ‐0.98 28231 SLCO4A1 ‐0.55333 ‐1.07667 ‐0.53333 0.6233333 0.47 0.43333333 0.73 0 ‐0.70333 0.023395229 ‐0.98 26157 GIMAP2 ‐0.17 ‐1.15 ‐1.59 ‐0.22 0.2335714 0 0.21 ‐0.11 ‐0.06 0.012810464 ‐0.978928572 51170 HSD17B11 ‐0.42333 ‐0.70333 ‐1.21667 0.4533333 0.4533333 ‐0.05666667 0.216667 0.013333 0.1 0.001802623 ‐0.977777778 10228 STX6 ‐0.825 ‐0.405 ‐0.955 0.49 0.53 0.26 ‐0.325 0.54 0 0.004321908 ‐0.9775 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 397 ARHGDIB ‐0.28 ‐0.32 ‐1.62 0.73 0.08 0.24 0.49 ‐0.145 0.015 0.026265449 ‐0.975 5440 POLR2K ‐0.83 ‐0.59 ‐1.44 ‐0.03 0 0.03 ‐0.4 0.21 0.31 0.003139412 ‐0.973333333 5042 PABPC3 ‐0.68 ‐0.17 ‐1.215 0.855 0.67 0.465 ‐0.375 0.165 ‐0.075 0.024723216 ‐0.9725 127933 UHMK1 ‐0.73333 ‐1.28 ‐0.93333 0.0933333 ‐0.0466667 0 0.38 ‐0.29667 ‐0.19667 0.000893217 ‐0.971111111 83442 SH3BGRL3 ‐0.63 ‐0.05 ‐1.41 ‐0.03 0.24 0.59 0 0.42 0.42 0.013943274 ‐0.97 478 ATP1A3 0 ‐0.65 ‐1.08 0.88 0.19 0.23 1.06 0 0 0.025571057 ‐0.97 6238 RRBP1 ‐0.6275 ‐0.8525 ‐1.1375 0.2075 0 0.13 0.165 0.145 ‐0.0675 6.77992E‐05 ‐0.969166667 152006 RNF38 ‐0.9 ‐0.95 ‐0.645 0.715 ‐0.09 ‐0.315 0.185 0.075 0.255 0.002965017 ‐0.969166667 4071 TM4SF1 ‐0.07 ‐0.95 ‐0.83 0 0.6525 0.3525 0.5575 0.335 0.2125 0.003860231 ‐0.968333333 196475 RMST 0.03 ‐1.24 ‐1.51292 ‐0.035 0.24 ‐0.035 0.14 0.0325 0 0.019055173 ‐0.964722222 83440 ADPGK ‐0.58 ‐1.03 ‐0.86 0.52 ‐0.06 0 0.28 0.28 ‐0.19 0.001084721 ‐0.961666667 161742 SPRED1 0 ‐0.575 ‐1.705 0.16 0.07 0.23 0.01 0.335 0.38 0.025673915 ‐0.9575 7184 HSP90B1 ‐0.93667 ‐0.56667 ‐0.94667 0 0.44 0.45 ‐0.38667 0.253333 0.056667 0.002446403 ‐0.952222223 29956 LASS2 ‐0.67 ‐0.635 ‐1.155 0.475 0.025 0 0.4 0.04 ‐0.17 0.001422678 ‐0.948333333 79897 RPP21 ‐0.64 ‐0.01 ‐1.11 ‐0.35 0.36 0.63 0 0.71 0.8 0.027780033 ‐0.945 79696 FAM164C ‐0.21 ‐0.45 ‐1.04 0 ‐0.34 0.84 0.94 0.6 0.23 0.027502194 ‐0.945 93986 FOXP2 ‐0.61777 ‐0.91 ‐1.055 0.025 ‐0.005 0 0.265 0.215 ‐0.025 7.16406E‐05 ‐0.940088889 7466 WFS1 ‐0.92 0.04 ‐1.21 ‐0.27 0.36 0.52 0.07 0.26 0.52 0.018188768 ‐0.94 1266 CNN3 ‐0.63667 ‐1.12667 ‐0.75667 ‐0.0866667 0 0.49666667 0.056667 0.106667 0.013333 0.000542542 ‐0.937777778 372 ARCN1 ‐0.7 ‐0.945 ‐1.155 ‐0.21 0.12 0.12 0.045 0 ‐0.075 8.18755E‐05 ‐0.933333333 7035 TFPI ‐0.335 ‐0.57 ‐1.35 0.34 0.685 ‐0.115 0.01 0.075 0.095 0.009613963 ‐0.933333333 54467 ANKIB1 ‐0.46333 ‐1.27667 ‐0.66667 0.2083333 0.48 ‐0.57666667 0.046667 0.406667 0.176667 0.012314998 ‐0.925833334 9404 LPXN ‐0.71 0.15 ‐1.03 ‐0.07 0.47 0.58 ‐0.4 0.86 0.91 0.04948372 ‐0.921666667 1948 EFNB2 ‐1.2975 ‐0.4 ‐1.0475 0.1658333 0.145 0.095 0.145 ‐0.53 0.005833 0.006097619 ‐0.919444444 83641 FAM107B ‐0.49 ‐1.14 ‐1.6 0.175 0.07 0.02 ‐0.545 ‐0.68 0.01 0.018517311 ‐0.918333333 54462 FAM190B ‐0.47 ‐0.54 ‐1.43 ‐0.2 0.11 ‐0.28 0.75 ‐0.12 0.37 0.021219173 ‐0.918333333 2519 FUCA2 ‐0.75 ‐0.08 ‐1.34 ‐0.06 0.14 0.3 0.38 0.27 0.13 0.00897902 ‐0.916666667 5019 OXCT1 ‐0.2975 ‐0.52 ‐1.6425 0.2 0 0.08 0.295 ‐0.1525 0.135 0.015753037 ‐0.912916667 51495 PTPLAD1 ‐1.27333 ‐0.89 ‐0.37667 ‐0.1466667 0.3433333 0 ‐0.32 0.236667 0.273333 0.005674749 ‐0.911111111 4851 NOTCH1 ‐0.73 ‐0.53 ‐0.585 1.1 0.1 0.005 0.2 0.275 0.095 0.007491216 ‐0.910833333 203328 SUSD3 ‐1.2 ‐0.93 ‐0.29 ‐0.35 0.76 0.35 ‐0.34 0.28 ‐0.08 0.02358415 ‐0.91 1655 DDX5 ‐0.18 ‐1.13 ‐1.35 0.07 0 0.02 0.19 ‐0.17 0.02 0.007597525 ‐0.908333333 3337 DNAJB1 ‐0.76 ‐0.74 ‐0.59 0.57 ‐0.12 0.43 0.18 ‐0.03 0.24 0.000785253 ‐0.908333333 79616 CCNJL ‐0.11 ‐0.05 ‐0.73 ‐0.13 0.78 0.69 0.61 1.17 0.54 0.016924764 ‐0.906666667 4440 MSI1 0 ‐0.47 ‐0.63 ‐0.11 0.9 0.94 0.01 1.18 0.31 0.034391216 ‐0.905 1203 CLN5 ‐0.38667 ‐0.56333 ‐0.82 0.5766667 0.1133333 ‐0.21666667 0.87 0.263333 0.266667 0.006938707 ‐0.902222222 2150 F2RL1 ‐0.51333 0 ‐0.90667 ‐0.0633333 0.4166667 0.40333333 0.52 0.766667 0.516667 0.006741465 ‐0.9 83659 TEKT1 ‐0.785 ‐1.63 ‐0.08 ‐0.17 0.63 0 ‐0.08 0.15 ‐0.12 0.034155439 ‐0.9 122769 PPIL5 ‐0.415 ‐0.12 ‐0.985 0.495 0.525 0.8 ‐0.325 0.345 0.495 0.01540747 ‐0.895833333 55916 NXT2 ‐0.445 ‐1.055 ‐1.2 0.085 0.32 0.095 ‐0.33 ‐0.325 0.095 0.004626096 ‐0.89 9368 SLC9A3R1 ‐0.94667 ‐0.92667 ‐0.62 0.24 ‐0.16 0.07 0.083333 0.056667 0.06 5.57354E‐05 ‐0.889444445 1465 CSRP1 ‐0.695 ‐0.285 ‐0.72167 0 0.3483333 0.525 0.441667 0.468333 0.141667 0.000696676 ‐0.888055556 1875 E2F5 ‐1.09 ‐1.215 ‐1.04 ‐0.35 ‐0.235 0.08 ‐0.6 ‐0.26 0 0.000603179 ‐0.8875 9422 ZNF264 ‐0.65 ‐0.575 ‐1.2 0.045 0.17 0.04 ‐0.195 0.165 0.25 0.00084311 ‐0.8875 3575 IL7R ‐0.80333 ‐0.03 ‐1.18667 ‐0.2 0.2933333 0 ‐0.13 0.76 0.553333 0.02834019 ‐0.886111111 157247 MGC27345 ‐1.165 ‐0.5 ‐0.83 ‐0.09 0.06 0.1 ‐0.01 0.215 0.045 0.000394613 ‐0.885 147463 ANKRD29 ‐0.22 ‐0.51 ‐1.40.650.66‐0.17 ‐0.3 ‐0.07 0.28 0.035867515 ‐0.885 93034 NT5C1B ‐0.81 ‐0.805 ‐1.195 ‐0.055 0.045 0.155 ‐0.68 0.075 0.14 0.003710749 ‐0.883333333 25972 UNC50 ‐0.79 ‐0.88 ‐0.72 0.28 0 ‐0.27 0.17 0.23 0.09 0.00018626 ‐0.88 10225 CD96 ‐0.88 ‐0.865 ‐0.29333 ‐0.175 ‐0.4425 0.27 0.8 0.303333 0.4275 0.020259454 ‐0.876666667 5932 RBBP8 ‐0.67 ‐0.67 ‐0.65 0.69 0 0.17 0.25 0.04 0.12 0.000641071 ‐0.875 3692 EIF6 ‐0.59 0 ‐1.39 ‐0.06 0.31 0.55 0.24 0.19 0.05 0.020382277 ‐0.873333333 9123 SLC16A3 ‐0.26333 ‐0.25333 ‐1.60667 ‐0.0833333 0.1633333 0.2 0.256667 0.23 0.223333 0.023850431 ‐0.872777778 716 C1S ‐0.4 ‐1.51 ‐0.08 0.56 ‐0.25 0.23 0.57 0 0.14 0.038263248 ‐0.871666667 4669 NAGLU ‐0.48 ‐0.37 ‐1.42 0.47 0.46 ‐0.07 0.48 ‐0.11 ‐0.54 0.034773124 ‐0.871666667 27436 EML4 ‐0.9925 ‐0.705 ‐0.4175 ‐0.0175 0.3 0.13 ‐0.0425 0.355 0.26 0.000613776 ‐0.869166667 112464 PRKCDBP ‐0.4 0 ‐1.415 0.08 0.565 0.375 ‐0.135 0.095 0.605 0.032895862 ‐0.869166667 5585 PKN1 ‐0.67 ‐0.1 ‐0.79 ‐0.02 0.29 1.04 0.36 0 0.42 0.014582351 ‐0.868333333 6919 TCEA2 ‐0.805 0.185 ‐0.865 ‐0.13 0.4 0.82 ‐0.15 0.585 0.715 0.036409002 ‐0.868333333 2764 GMFB ‐0.625 ‐0.475 ‐1.075 ‐0.075 0.21 0.68 ‐0.34 0.175 0.2 0.007772379 ‐0.866666667 934 CD24 0 ‐0.8175 ‐0.9725 0.1225 0.495 0.23 0.5825 0.06 0.13 0.007980046 ‐0.866666667 162417 NAGS ‐0.665 ‐0.465 ‐0.75 0.125 0 0.625 0.005 0.335 0.345 0.000833671 ‐0.865833333 3487 IGFBP4 ‐0.575 0.115 ‐1.495 ‐0.255 0.265 0.745 0.115 0.29 0.125 0.04796167 ‐0.865833333 79695 GALNT12 ‐0.34 ‐0.2 ‐0.31 0.86 0.44 0.83 0.82 0 0.53 0.003625536 ‐0.863333333 84915 C12orf34 ‐0.86 ‐0.21 ‐0.93357 0.33 0.15 ‐0.33 0.44 0.11 0.47 0.007521324 ‐0.862857143 805 CALM2 ‐0.69 ‐0.88 ‐0.91 0.24 0.14 ‐0.22 ‐0.01 0.06 0 7.12841E‐05 ‐0.861666667 1176 AP3S1 ‐1.18 ‐0.29 ‐0.175 0 0.77 0.34 0.17 0.33 0.26 0.012666214 ‐0.86 401466 C8orf59 ‐0.88 ‐0.99 ‐0.53 ‐0.425 0.3 ‐0.08 ‐0.25 0.645 0.165 0.010949319 ‐0.859166667 60682 SMAP1 ‐0.405 ‐0.81 ‐0.87 0.05 0.125 0.39 0.205 0.07 0.13 0.000197748 ‐0.856666667 3796 KIF2A ‐0.505 ‐0.81 ‐1.26 0.08 ‐0.15 ‐0.22 0.09 0.21 ‐0.03 0.001669227 ‐0.855 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 26166 RGS22 0.22775 ‐1.10225 ‐1.35225 0.49775 0.17775 0 0.12775 ‐0.15225 0.0035 0.044090645 ‐0.851333333 6373 CXCL11 ‐0.7 ‐0.16 ‐0.44 ‐0.1785714 0 ‐0.02 0.56 1.18 0.95 0.047558921 ‐0.848571429 7295 TXN ‐0.95 ‐0.65 ‐0.97 ‐0.255 0.185 ‐0.125 ‐0.245 0.22 0.17 0.000777586 ‐0.848333333 5311 PKD2 ‐1.07 ‐0.595 ‐0.815 ‐0.23 0.215 0 ‐0.13 0.105 0.11 0.000421434 ‐0.838333333 26578 OSTF1 ‐0.9 ‐0.74 ‐0.78 0.04 ‐0.18 ‐0.14 0.18 0.27 0.01 0.000121164 ‐0.836666667 10763 NES 0.035 ‐0.67 ‐1.11 0 0.62 0.24 0.38 0.11 0.18 0.013388015 ‐0.836666667 7318 UBA7 ‐0.59333 ‐0.57333 ‐0.89 ‐0.2166667 0.2766667 0.39 0.303333 0 0.133333 0.000872815 ‐0.833333333 523 ATP6V1A ‐0.895 ‐0.925 ‐0.58 0.165 ‐0.08 0 0.255 ‐0.07 ‐0.075 0.000145999 ‐0.8325 3720 JARID2 ‐1.48 ‐0.18 ‐1.24 ‐0.46 0.1 ‐0.51 0 0.32 ‐0.26 0.038591931 ‐0.831666667 6382 SDC1 ‐0.8025 ‐0.4275 ‐0.5875 0.4666667 ‐0.085 0.09 0.76 0.1 0.02 0.004825355 ‐0.831111111 51000 SLC35B3 ‐0.86 ‐0.42 ‐0.85 ‐0.11 0.23 0.18 0.12 0.18 0.1 0.0002235 ‐0.826666667 89781 HPS4 ‐0.63667 ‐0.68 ‐0.54 0.2133333 0 0.15333333 0.573333 0.046667 0.26 0.000300584 ‐0.826666667 595 CCND1 ‐0.2275 ‐0.23 ‐1.345 0.3675 0.1575 0.33 0.085 0.2925 0.115 0.0140496 ‐0.825416667 7422 VEGFA ‐0.22167 ‐0.33 ‐1.59 0 0.0066667 0.11 0.113333 0.33 0.106667 0.027097574 ‐0.825 54937 SOHLH2 ‐0.02644 ‐0.88 ‐0.71 ‐0.0626667 0.03 0 0.31 0.23875 1.2 0.040568265 ‐0.824828704 2820 GPD2 ‐0.53 ‐0.88 ‐0.56 ‐0.04 0.44 0.2 ‐0.37 0.34 0.42 0.004865799 ‐0.821666667 5154 PDGFA ‐1.135 ‐0.98 ‐0.775 ‐0.35 0.095 ‐0.255 ‐0.485 0.14 0 0.001776741 ‐0.820833333 158763 ARHGAP36 ‐1.00306 0.036944 ‐0.92306 0 0.0269444 ‐0.04398148 0.766944 0.236944 0.157222 0.023113822 ‐0.820401235 8290 HIST3H3 ‐0.87 ‐0.77 ‐0.9 ‐0.03 ‐0.06 0.01 ‐0.41 0.2 0.1 0.000361987 ‐0.815 54956 PARP16 ‐0.51 0 ‐1.12 0.53 ‐0.16 0.09 0.86 0.15 0.16 0.031238699 ‐0.815 285521 COX18 ‐1.24 ‐0.185 ‐0.71 ‐0.18 ‐0.105 0.205 ‐0.14 0.42 0.415 0.016605922 ‐0.814166667 6576 SLC25A1 ‐0.82 ‐0.7 ‐0.575 ‐0.025 0.015 0.335 0.335 0 0.03 0.000171973 ‐0.813333333 114569 MAL2 ‐0.485 ‐0.36 ‐1.225 ‐0.14 0.055 0 0.165 0.29 0.355 0.006006401 ‐0.810833333 79886 C9orf82 ‐0.11 ‐0.54 ‐1.09 0.43 0 ‐0.02 0.49 0.04 0.44 0.011151277 ‐0.81 4804 NGFR ‐0.00667 ‐0.19 ‐1.29 0.0266667 0.43 0.61 0.17 0 0.643333 0.036411985 ‐0.808888889 10020 GNE ‐0.69 ‐0.4 ‐1.04 ‐0.24 0.45 ‐0.23 0.03 0.21 0.37 0.00694736 ‐0.808333333 83660 TLN2 ‐0.3575 ‐0.42 ‐1.2125 0.045 0.105 0.13416667 0.5475 ‐0.025 0.0625 0.007537782 ‐0.808194445 53836 GPR87 ‐0.03 ‐0.105 ‐1.18 0.015 0.43 0.94 0.33 0.35 0.13 0.03555793 ‐0.804166667 168002 DACT2 ‐0.21 ‐0.7 ‐1.14 0.16 0.34 0.14 0.13 ‐0.1 0.05 0.004555496 ‐0.803333333 11235 PDCD10 ‐0.55 ‐0.89 ‐0.72 0.02 ‐0.09 ‐0.14 0.55 0.14 0 0.001706523 ‐0.8 5148 PDE6G ‐0.795 0 ‐1.3 0.15 0.064375 ‐0.105 0.49 0.00375 ‐0.004 0.023725511 ‐0.7981875 51125 GOLGA7 ‐0.55 ‐1.17 ‐0.47 0.23 ‐0.105 ‐0.155 0.555 ‐0.085 ‐0.045 0.008395065 ‐0.795833333 85455 DISP2 ‐0.42 ‐0.48 ‐0.68 0.23 0 0.05 ‐0.19 0.6 0.92 0.016600517 ‐0.795 9002 F2RL3 ‐0.25 ‐0.345 ‐0.95 0.075 0.44 0.47 ‐0.385 0.07 1.01 0.040757437 ‐0.795 9886 RHOBTB1 ‐0.76 ‐1.09 0.06 0.51 ‐0.05 0 0.56 0.14 0 0.024552605 ‐0.79 23550 PSD4 ‐0.47 ‐0.52 ‐0.75 0.33 ‐0.08 0 0.685 0.16 0.15 0.002627741 ‐0.7875 23057 NMNAT2 ‐0.555 ‐0.17 ‐0.555 0.1608704 0.575 0.59 0 0.435 0.395 0.001946967 ‐0.785978395 80351 TNKS2 ‐0.87 ‐0.75 ‐0.82 0 0.19 0.08 0.1 ‐0.36 ‐0.18 0.000401839 ‐0.785 4162 MCAM ‐0.865 ‐0.575 ‐0.495 0.485 0.12 0.28 0.36 ‐0.035 ‐0.37 0.005557751 ‐0.785 9478 CABP1 ‐0.48236 ‐0.53125 ‐0.98069 0 0.2065625 0.27875 ‐0.026 0.04875 0.20875 0.000496656 ‐0.784237268 88455 ANKRD13A ‐0.24 ‐0.65 ‐0.57 0.5733333 0.36 0.41666667 0.295 0.13 ‐0.00667 0.001175951 ‐0.781388889 23157 40427 ‐0.53 ‐0.55 ‐1.26333 0.2133333 ‐0.1433333 0.09666667 0.17 ‐0.13667 ‐0.20333 0.004711379 ‐0.780555556 51621 KLF13 ‐0.47 ‐0.40833 ‐0.37833 0.4416667 0.22 0 1.076667 0.216667 0.196667 0.01104604 ‐0.7775 476 ATP1A1 ‐0.47 ‐0.39 ‐0.94 0.265 0.15 0.13 0.46 0 0.035 0.00136137 ‐0.773333333 2168 FABP1 ‐0.98 0 ‐1.04 0.32 ‐0.32 ‐0.25 0.72 0.16 ‐0.03 0.046345059 ‐0.773333333 4814 NINJ1 ‐0.37 0 ‐0.26 ‐0.3 0.84 0.76 0.14 0.95 0.99 0.046888347 ‐0.773333333 60 ACTB ‐0.418 ‐0.566 ‐1.114 0.578 ‐0.012 0.154 0.194 ‐0.36 ‐0.114 0.01340416 ‐0.772666667 170062 FAM47B ‐0.56585 ‐0.37969 ‐1.01 0.14 0.54 0.05888889 0.34 ‐0.305 ‐0.05015 0.008859094 ‐0.772469136 81542 TMX1 ‐0.405 ‐0.595 ‐0.975 0.075 0 ‐0.25 0.565 0.125 0.165 0.005204231 ‐0.771666667 23214 XPO6 ‐1.03333 ‐1.20833 ‐0.11 ‐0.16 ‐0.0033333 0.22 ‐0.32667 0.176667 0.001667 0.019395624 ‐0.768611111 57446 NDRG3 ‐0.815 ‐0.505 ‐0.55 ‐0.005 0.605 0 ‐0.245 0.15 0.35 0.004990196 ‐0.765833333 171586 ABHD3 ‐0.84 ‐0.6 ‐0.8 ‐0.24 0 0.11 0.04 0.1 0.1 7.88573E‐05 ‐0.765 4026 LPP ‐0.69 ‐0.135 ‐1.045 0 0.385 0.05 ‐0.18 0.46 0.135 0.011611177 ‐0.765 57175 CORO1B ‐0.25 ‐0.34 ‐0.96 0.53 0 0.58 0.2 ‐0.07 0.22 0.00978294 ‐0.76 84932 RAB2B ‐0.77 ‐0.265 ‐0.86 ‐0.32 ‐0.285 0.485 0.17 0.41 0.31 0.016322064 ‐0.76 10397 NDRG1 ‐0.0225 ‐0.6525 ‐1.0725 0.11 0.405 0.105 0.605 0 ‐0.165 0.022606388 ‐0.759166667 152831 KLB ‐0.6935 ‐0.4435 ‐0.8835 0.0465 0.0259444 0 0.3665 ‐0.2135 0.2765 0.001478297 ‐0.757157407 91768 CABLES1 ‐1.18 ‐0.59 ‐0.02 ‐0.11 0 ‐0.06 0.49 0.32 0.32 0.024333221 ‐0.756666667 84678 KDM2B 0.03 ‐0.74 ‐1.31 0.5 ‐0.09 ‐0.2 0.13 0.15 0 0.036646922 ‐0.755 51444 RNF138 ‐0.69 ‐1.285 ‐0.245 0.42 ‐0.175 0.015 ‐0.05 ‐0.14 0.01 0.01493825 ‐0.753333333 3552 IL1A ‐0.56 ‐0.48333 ‐1.1 ‐0.3466667 ‐0.18 ‐0.02 0.416667 0.06 0.303333 0.009649174 ‐0.753333333 29927 SEC61A1 ‐0.215 ‐0.6 ‐0.705 0.785 ‐0.155 0.27 0.635 ‐0.06 0 0.020407319 ‐0.7525 5355 PLP2 ‐0.34 ‐0.04 ‐1.485 0.03 0.405 0.155 0 0.255 ‐0.07 0.044524455 ‐0.750833333 2030 SLC29A1 ‐0.86 0 ‐0.77 0.03 0.45 0.34 ‐0.03 0.27 0.18 0.00902347 ‐0.75 221443 C6orf130 ‐0.42 ‐0.15 ‐1.45 0.11 0.13 0.09 0.08 0 0.04 0.024033261 ‐0.748333333 27239 GPR162 ‐0.72 ‐0.39 ‐0.04 0.505 0.22 0.465 0.75 0.15 0.09 0.00707063 ‐0.746666667 10083 USH1C 0 ‐0.48222 ‐1.25 ‐0.01 0.81 0.05388889 0.14 ‐0.11 0.1175 0.046586009 ‐0.744305556 55124 PIWIL2 ‐0.27125 ‐0.67 ‐1.22 0.04325 0.34 ‐0.24291667 0.26 0.01 ‐0.28 0.015993517 ‐0.742138889 5768 QSOX1 ‐0.28 ‐0.32 ‐1.34 0.05 0.1 0.21 0.14 0.04 0.03 0.014815901 ‐0.741666667 254170 FBXO33 ‐0.615 ‐0.375 ‐0.92 0.37 0 0.06 ‐0.055 ‐0.005 0.235 0.001322493 ‐0.7375 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 54566 EPB41L4B ‐0.275 ‐0.465 ‐0.765 0.35 0.39 0.39 0.13 0 0.151667 0.000962045 ‐0.736944445 1847 DUSP5 ‐0.535 ‐0.52 ‐1.1 ‐0.03 0.015 0.02 0.12 ‐0.015 0 0.000725286 ‐0.736666667 8492 PRSS12 ‐0.325 0.01 ‐1.175 0.595 0.215 ‐0.055 0 0.455 0.22 0.032191668 ‐0.735 83874 TBC1D10A ‐0.21 ‐0.38 ‐1.13 0.18 0 0.02 0.57 0.25 ‐0.05 0.015364419 ‐0.735 9605 C16orf7 ‐1.03361 ‐0.42361 ‐0.54361 ‐0.0636111 0.3563889 0.22638889 0 ‐0.24361 0.126389 0.004338468 ‐0.733935185 5468 PPARG ‐0.065 ‐0.37 ‐0.865 0.525 0.05 0.185 0.9 0.18 ‐0.05 0.026150624 ‐0.731666667 384 ARG2 ‐0.59 ‐1.17 ‐0.38 ‐0.11 ‐0.05 0.15 0.57 ‐0.29 ‐0.16 0.018527971 ‐0.731666667 7424 VEGFC ‐0.375 ‐0.075 ‐1.12 ‐0.08 0.29 0 0.26 0.49 0.285 0.018398471 ‐0.730833333 7045 TGFBI ‐0.27167 ‐0.15833 ‐0.87 0.44 0.5483333 0.28166667 ‐0.03167 0.391667 0.155 0.0065741 ‐0.730833333 23321 TRIM2 ‐0.71 ‐0.7 ‐0.755 0.05 0.03 ‐0.205 0.105 0 0.05 1.10208E‐05 ‐0.726666667 9743 ARHGAP32 0 ‐0.30667 ‐1.25667 0.3033333 0.1366667 0.08666667 0.16 0.323333 0.216667 0.024451686 ‐0.725555556 57696 DDX55 ‐0.83 ‐0.69 ‐0.41 0.55 0.1 0.14 ‐0.59 0.17 0.12 0.017777352 ‐0.725 54961 SSH3 ‐1.095 ‐0.77 ‐0.825 0.58 ‐0.355 ‐0.6 0 ‐0.38 ‐0.28 0.025998421 ‐0.724166667 285636 C5orf51 ‐1.13 ‐0.34 ‐0.665 0 0.025 0.135 0.06 ‐0.105 ‐0.045 0.002559619 ‐0.723333333 3556 IL1RAP ‐0.178 ‐0.6225 ‐0.54 0.156 0.428 0.025 0 0.5425 0.5025 0.003947704 ‐0.7225 79158 GNPTAB ‐0.7375 ‐0.1075 ‐0.795 ‐0.015 0.1925 0 0.495 0.295 0.0875 0.005959417 ‐0.7225 9110 MTMR4 ‐0.92 ‐1.16 ‐0.25 ‐0.26 0.09 0.01 ‐0.195 0.15 ‐0.13 0.009427381 ‐0.720833333 91107 TRIM47 ‐0.56 0.01 ‐0.91 ‐0.065 0.17 0.415 0 0.5 0.385 0.014851758 ‐0.720833333 126731 C1orf96 ‐1.11 ‐0.76 ‐0.36167 0 0.4316667 ‐0.0925 ‐0.715 0.115 0.121667 0.031472014 ‐0.720694445 64398 MPP5 ‐0.935 0 ‐1.18 ‐0.2 0.325 0.005 ‐0.465 0.195 0.225 0.045330297 ‐0.719166667 64759 TNS3 ‐0.14 ‐0.85 ‐0.325 0.62 0.715 0.18 ‐0.01 0.2 ‐0.025 0.018229658 ‐0.718333333 1293 COL6A3 ‐0.14667 ‐0.22333 ‐1.32 0.0983333 0.2733333 0.31083333 0.453333 ‐0.18 ‐0.02667 0.039833207 ‐0.718194444 3772 KCNJ15 ‐0.44407 ‐0.46357 ‐0.93 0.03 ‐0.29 0.21 ‐0.09 ‐0.06 0.83 0.026262414 ‐0.717548501 8674 VAMP4 ‐0.4 ‐0.71 ‐0.63 0.175 0.335 ‐0.045 0.13 0 0.23 0.000239258 ‐0.7175 25796 PGLS ‐0.68 ‐0.5 ‐0.82 0.52 ‐0.19 0.11 0 0.05 ‐0.21 0.004029178 ‐0.713333333 2122 MECOM ‐0.9125 ‐0.3875 ‐0.41667 0.2025 0 0.22 0.266667 0.06 0.0925 0.000838103 ‐0.7125 57153 SLC44A2 ‐0.35333 ‐0.45 ‐0.95667 0 0.29 0.17666667 0.076667 0.123333 0.083333 0.001217692 ‐0.711666667 79686 C14orf139 ‐1.03 ‐0.38 ‐0.31 0.21 0.49 0.3 ‐0.04 ‐0.14 0 0.01093117 ‐0.71 84141 FAM176A ‐0.19 ‐0.195 ‐1.065 0.185 0.155 ‐0.105 0.345 0.4 0.37 0.015212499 ‐0.708333333 55334 SLC39A9 ‐0.7 ‐0.59 ‐0.61 0.27 0.21 ‐0.25 0.58 ‐0.475 0.105 0.017304106 ‐0.706666667 126299 ZNF428 ‐0.12 ‐0.48 ‐1.03 0.64 0 0.15 ‐0.52 0.32 0.39 0.047689258 ‐0.706666667 3371 TNC ‐0.3625 ‐0.46 ‐0.54 0.2525 0.3933333 0.14 0.65 0.066667 0 0.002019248 ‐0.704583333 80023 NRSN2 ‐0.89 ‐0.08 ‐0.565 ‐0.26 0.635 0.545 0 0.005 0.23 0.029296274 ‐0.704166667 55754 TMEM30A ‐0.14 ‐0.37 ‐1.1 0.615 0 ‐0.205 0.41 0.07 0.105 0.030260068 ‐0.7025 2768 GNA12 ‐0.5975 ‐0.5025 ‐0.7475 0.0925 ‐0.1366667 0.09333333 0.5675 ‐0.1275 0.03 0.003252519 ‐0.702361111 3554 IL1R1 ‐0.93 0.365 ‐0.89 0.105 0.2 0 0.24 0.46 0.295 0.048410669 ‐0.701666667 81611 ANP32E ‐0.3525 ‐1.096 ‐0.128 0.698 0.464 0.072 ‐0.072 0 ‐0.108 0.037721278 ‐0.701166667 84068 SLC10A7 ‐0.22 ‐0.94 ‐0.66 0.46 0.26 0 0.33 ‐0.165 ‐0.34 0.01928072 ‐0.6975 10653 SPINT2 ‐0.3 0.035 ‐1.095 0.385 0.5 0.295 0.39 0.18 ‐0.29 0.039969371 ‐0.696666667 9524 TECR ‐0.76 0 ‐0.78 ‐0.16 0.61 0.64 ‐0.36 0.14 0.22 0.049492836 ‐0.695 22809 ATF5 ‐0.19 0 ‐0.83 0.3 ‐0.18 0.395 0.945 0.305 0.33 0.037929874 ‐0.689166667 55707 NECAP2 ‐0.07 ‐0.85 ‐0.695 0.405 ‐0.02 0 0.49 ‐0.02 0.045 0.013309683 ‐0.688333333 7138 TNNT1 ‐0.46 ‐0.04 ‐0.77 0.37 0.47 0.45 0.65 0 ‐0.35 0.033469129 ‐0.688333333 11057 ABHD2 ‐0.49833 ‐0.59667 ‐0.52 0.3766667 ‐0.06 0.12333333 0.4 0 0.056667 0.00064741 ‐0.687777778 23113 CUL9 ‐0.35 ‐0.33 ‐1.09 0.35 0.12 0.15 ‐0.16 0 0.12 0.009121604 ‐0.686666667 55612 FERMT1 ‐0.29 0 ‐1.2 0.2 0.13 ‐0.01 0.16 0.25 0.41 0.02900949 ‐0.686666667 10741 RBBP9 ‐0.615 ‐0.67 ‐1.145 ‐0.31 0 ‐0.29 0.143333 ‐0.32333 0.036667 0.004345504 ‐0.686111111 402317 OR2A42 ‐0.69 ‐0.5 ‐0.391 ‐0.14 0.16 0.96 ‐0.43833 0.18 0.23 0.047215174 ‐0.685611111 220213 OTUD1 ‐0.05111 ‐0.52 ‐0.6 0 0.36 0.22 ‐0.12 0.83 0.48 0.021986499 ‐0.68537037 1308 COL17A1 ‐0.35 ‐0.3175 ‐0.9575 ‐0.09 0.12 0.155 0.1425 0.0375 0.49 0.006445757 ‐0.684166667 56882 CDC42SE1 ‐0.51333 ‐1.14333 ‐0.05667 0.4566667 ‐0.29 0.05333333 0.523333 ‐0.15667 0.09 0.046316317 ‐0.683888889 10919 EHMT2 ‐0.305 ‐0.075 ‐1.235 0 ‐0.015 0.2 0.22 0.315 0.15 0.026834393 ‐0.683333333 377 ARF3 ‐0.36 ‐0.97333 ‐0.73667 0 ‐0.19 ‐0.28 0.4 ‐0.02333 0.053333 0.007324628 ‐0.683333333 9761 MLEC ‐0.50667 ‐0.11 ‐1.12 0.29 0.0466667 0.25 ‐0.38667 0.386667 0.02 0.031771768 ‐0.68 219855 SLC37A2 ‐0.23 0 ‐0.79 0.25 0.92 0.3 0 0.13 0.44 0.027845036 ‐0.68 7534 YWHAZ ‐0.10667 ‐0.57514 ‐0.91639 0.4048611 0.0086111 0 0.343333 0.094444 0.026111 0.008560387 ‐0.678958333 51465 UBE2J1 ‐0.80333 ‐0.55 ‐0.33667 0 ‐0.25 0.14333333 0.67 0.086667 0.043333 0.012027562 ‐0.678888889 255022 CALHM1 ‐0.57 ‐0.17283 ‐1.05063 0.1216667 0.36 0.10216667 0.07 ‐0.23 0.06 0.011737776 ‐0.678458333 7707 ZNF148 ‐0.81 ‐0.22 ‐0.72 ‐0.04 0.21 0.06 0.01 0.35 ‐0.02 0.00284832 ‐0.678333333 8572 PDLIM4 ‐0.97 0.01 ‐0.59 ‐0.4 0.18 0.62 0.04 0.39 0.14 0.044724271 ‐0.678333333 3976 LIF ‐0.7975 0.045 ‐1.045 ‐0.125 0.2283333 0.16 0.125 ‐0.0175 0.095 0.021303435 ‐0.676805556 5819 PVRL2 ‐0.49 ‐0.66667 ‐0.82667 0.1266667 ‐0.07 0.1 0.126667 0 ‐0.19 0.000251656 ‐0.676666667 8358 HIST1H3B ‐0.795 ‐0.26 ‐0.52 ‐0.125 0.13 0.54 ‐0.265 0.26 0.37 0.013906309 ‐0.676666667 163 AP2B1 ‐0.278 ‐0.098 ‐1.228 0.018 0.406 0.208 ‐0.016 ‐0.076 0.306 0.034056636 ‐0.675666667 29931 LOH3CR2A ‐0.015 ‐0.515 ‐0.28217 0.275 0.74 0.195 0.72 0.22 0.275 0.006987343 ‐0.674888889 57181 SLC39A10 ‐0.74 ‐0.72 ‐0.5 0.18 0.09 0.13 0.28 ‐0.39 ‐0.17 0.003749618 ‐0.673333333 158947 ARMCX4 ‐0.26 ‐0.50563 ‐1.16 0 0.0233333 0.01928571 0.09 0.1225 ‐0.07 0.007384909 ‐0.672728175 79102 RNF26 ‐0.62 ‐0.58 ‐0.8 ‐0.3 0.07 0.06 0.19 0 0.01 0.000426772 ‐0.671666667 2203 FBP1 ‐0.64667 ‐0.09 ‐0.82333 ‐0.0233333 0.3 0.34666667 ‐0.16667 0.146667 0.296667 0.00967157 ‐0.67 23197 FAF2 ‐0.575 ‐0.275 ‐0.7 0.305 0.095 0.15 ‐0.08 0.16 0.29 0.000753042 ‐0.67 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 1956 EGFR ‐0.492 ‐0.406 ‐0.8045 0 0.2005 ‐0.176 0.146 0.002 0.434 0.002760806 ‐0.668583333 1213 CLTC ‐0.51167 ‐0.54333 ‐0.44333 0.4483333 0 ‐0.04666667 0.266667 0.19 0.148333 0.000501944 ‐0.667222222 11341 SCRG1 ‐1.37 ‐0.1513 ‐0.13 0 0.04 ‐0.0215 0.29 0.11 0.28 0.049195902 ‐0.666848765 26499 PLEK2 ‐0.54 ‐0.11 ‐0.97 ‐0.17 0.44 0.26 0 0.17 0.06 0.014437085 ‐0.666666667 1360 CPB1 ‐0.82 0 ‐0.88 0.34 0.21 0.01 ‐0.04 0.11 ‐0.03 0.014531121 ‐0.666666667 10090 UST ‐0.7095 ‐0.415 ‐0.2995 0.1385 0.3605 ‐0.195 0.1425 0.27 0.4265 0.003536291 ‐0.665166667 6640 SNTA1 ‐0.37 ‐0.835 ‐0.7 0.265 ‐0.215 0.05 0.15 ‐0.07 0 0.001706805 ‐0.665 388558 ZNF808 ‐0.66 ‐0.27 ‐0.76 0.38 0 ‐0.07 0.23 0.12 ‐0.05 0.002451084 ‐0.665 8301 PICALM 0.003333 ‐0.38 ‐1.07667 0.28 0 0.20333333 0.48 0.176667 ‐0.06 0.026642786 ‐0.664444445 11014 KDELR2 ‐0.53 ‐0.58125 ‐0.325 0 0.315 0.15875 ‐0.0275 0.37875 0.285 0.00064159 ‐0.66375 79792 GSDMD ‐0.405 ‐0.305 ‐1.1875 0.09 0 0.11 0.0725 ‐0.1375 0.0475 0.010269941 ‐0.662916667 9371 KIF3B ‐0.56429 ‐0.49857 ‐1.11571 0.0628571 0.05 0 ‐0.25286 0.071429 ‐0.31429 0.005042403 ‐0.662380953 4215 MAP3K3 ‐0.21 ‐0.34 ‐0.47 0.02 0.265 0.44 0 0.495 0.71 0.006788245 ‐0.661666667 10276 NET1 ‐0.46 ‐0.45 ‐0.755 0.205 0.335 ‐0.1 0.325 ‐0.135 0 0.002340976 ‐0.66 6935 ZEB1 ‐0.435 ‐0.16 ‐0.57 0.215 0.795 0 ‐0.165 0.845 ‐0.06 0.048166559 ‐0.66 3059 HCLS1 ‐0.27 ‐0.15 ‐1.205 0.065 ‐0.115 0 0.345 0.065 0.35 0.031346474 ‐0.66 3442 IFNA5 ‐0.33 ‐0.18214 ‐1.00857 ‐0.22 0.08 0.11 0.2215 0.65 0.074444 0.027615524 ‐0.659562169 54916 C14orf101 ‐0.76 ‐0.64 ‐0.41 0.28 0.17 0.11 ‐0.35 0.07 0.04 0.002710001 ‐0.656666667 11123 RCAN3 ‐0.54 ‐0.23 ‐1.08 0.33 ‐0.08 0.18 ‐0.22 0.01 0 0.013637983 ‐0.653333333 9582 APOBEC3B ‐0.104 0 ‐0.552 0.881 0.53 0.226 0.5485 0.1235 0.286 0.013708593 ‐0.651166667 284119 PTRF ‐1.055 ‐0.135 ‐0.755 0.4 0.31 ‐0.065 ‐0.45 0 ‐0.18 0.039938337 ‐0.650833333 81570 CLPB ‐0.63 ‐0.39 ‐0.52 0.2 ‐0.15 0.46 0.24 0.07 0 0.001896386 ‐0.65 23729 SHPK ‐0.98 ‐1.02 ‐0.02 ‐0.34 0.07 0 ‐0.09 0.12 0.1 0.029131157 ‐0.65 4124 MAN2A1 ‐0.295 ‐0.2 ‐0.9325 0.565 0.215 ‐0.0625 0.435 ‐0.11 0 0.023287603 ‐0.649583333 3678 ITGA5 ‐0.36 ‐0.15667 ‐0.73667 ‐0.04 0.3566667 0.34333333 0.04 0.403333 0.273333 0.004377302 ‐0.647222222 56624 ASAH2 ‐0.79783 ‐0.37783 ‐0.59783 ‐0.1773333 0.1321667 0.20216667 ‐0.39783 0.122167 0.452167 0.013088945 ‐0.64675 81533 ITFG1 ‐0.41 ‐0.2 ‐0.93 0.17 0.25 0.03 0.43 0.29 ‐0.37 0.021491173 ‐0.646666667 4693 NDP ‐0.66333 0.006667 ‐0.92 0.0233333 0.0066667 0.11333333 ‐0.00333 0.066667 0.513333 0.020240836 ‐0.645555555 7919 BAT1 ‐0.415 ‐0.4125 ‐0.425 0 0.355 0.685 ‐0.135 0.2125 0.235 0.007064207 ‐0.642916667 71 ACTG1 ‐0.30333 ‐0.20333 ‐1.03 0.5133333 0.0166667 0.12666667 0.3 ‐0.07333 ‐0.1 0.023144847 ‐0.642777778 5409 PNMT ‐0.825 ‐0.41 ‐0.925 ‐0.57 0.085 0.015 ‐0.155 0 0.145 0.01102375 ‐0.64 84959 UBASH3B ‐0.295 ‐0.025 ‐0.54 0.47 0.465 0.155 0 0.415 0.6 0.006445941 ‐0.6375 6455 SH3GL1 ‐0.745 ‐0.125 ‐0.67 ‐0.195 0.16 0.29 0 0.21 0.28 0.007261492 ‐0.6375 64858 DCLRE1B ‐0.225 ‐0.33 ‐0.745 0.635 0 0.21 0.425 ‐0.06 0.015 0.013720037 ‐0.6375 58525 WIZ ‐0.38 ‐0.87 ‐0.31 0.58 ‐0.15 ‐0.05 0.44 ‐0.11 ‐0.01 0.022772275 ‐0.636666667 64411 ARAP3 0 ‐0.14 ‐0.72 0.74 0.22 0.07 0.45 0.39 0.22 0.016053942 ‐0.635 54972 TMEM132A ‐0.14 ‐0.13 ‐1.05 0.29 0.45 0.13 0 0.2 0.1 0.023862932 ‐0.635 7130 TNFAIP6 ‐0.03278 ‐0.46 ‐1.12 0.06 0.41 0.12 ‐0.09375 0 0.085714 0.028530616 ‐0.63458664 4643 MYO1E ‐0.4725 ‐0.2025 ‐0.6575 0.12 0.1075 0.1125 0.395833 0.2625 0.1425 0.000722156 ‐0.634305556 3384 ICAM2 ‐0.605 0 ‐1.085 ‐0.19 0.115 0.095 0.03 0.225 0.15 0.024710891 ‐0.634166667 51265 CDKL3 ‐0.83 ‐0.08 ‐0.33 0.41 ‐0.14 0.25 0.36 0 0.44 0.016702995 ‐0.633333333 8309 ACOX2 ‐0.32333 ‐0.11 ‐0.48 ‐0.1866667 0.3666667 0.52666667 0.356667 0.423333 0.483333 0.007627387 ‐0.632777778 85450 ITPRIP ‐0.13 ‐0.045 ‐0.62 0.52 0 0.775 0.46 0.075 0.355 0.019630542 ‐0.629166667 55679 LIMS2 ‐0.365 ‐0.065 ‐0.77 0 0.555 0.275 ‐0.24 0.24 0.535 0.028190455 ‐0.6275 65996 MGC2752 ‐0.32333 ‐0.48333 ‐0.85 0.21 ‐0.0933333 ‐0.15 0.323333 0.16 0 0.004215881 ‐0.627222222 23400 ATP13A2 ‐0.495 ‐0.105 ‐0.73 ‐0.135 0.455 0.32 ‐0.085 0.33 0.205 0.012239106 ‐0.625 4277 MICB ‐0.24333 ‐0.18667 ‐0.68667 0.3366667 0 0.29 0.446667 0.246667 0.193333 0.002628263 ‐0.624444445 79973 ZNF442 0 ‐0.91 ‐0.75 0.38 0.23 ‐0.22 0.2 ‐0.19 0.02 0.0321482 ‐0.623333333 126133 ALDH16A1 ‐0.835 0 ‐0.705 6.94E‐18 0.2 0.41 ‐0.28 0.085 0.24 0.025875958 ‐0.6225 1327 COX4I1 ‐1.1875 0.0475 ‐0.48 ‐0.08 0.215 0.235 0.105 0.0025 0 0.040034971 ‐0.619583333 374 AREG 0.075 ‐0.425 ‐0.8 ‐0.01 0.325 ‐0.12 0.625 0.305 0.29 0.030912015 ‐0.619166667 4664 NAB1 ‐0.465 ‐0.38 ‐0.61 0.225 0.21 0 0.12 0.285 ‐0.045 0.000244098 ‐0.6175 1543 CYP1A1 ‐0.45 0.24 ‐0.45 0 0.63 0.26 0.35 0.61 0.53 0.02152193 ‐0.616666667 10904 BLCAP ‐0.41167 ‐0.51833 ‐1.05167 0.48 ‐0.155 0.14833333 0 ‐0.265 ‐0.49833 0.038907569 ‐0.612222222 56983 KTELC1 ‐0.3 ‐0.77333 ‐0.72 0.6133333 0.0666667 ‐0.4 0.023333 0 ‐0.21667 0.030761952 ‐0.612222222 221491 C6orf1 ‐0.325 0 ‐0.83 ‐0.03 0.235 0.41 0.47 0.215 0.06 0.016737986 ‐0.611666667 7099 TLR4 ‐0.455 ‐0.135 ‐0.68 0 0.31 0.42 ‐0.36 0.46 0.3 0.024379439 ‐0.611666667 64175 LEPRE1 ‐0.52 ‐0.18 ‐0.68 0.09 0.09 0.22 0 0.23 0.28 0.001155075 ‐0.611666667 54968 TMEM70 ‐0.7 ‐0.52 ‐0.38 ‐0.01 0 0.16 0 0.17 0.14 0.000127212 ‐0.61 6386 SDCBP ‐0.53667 0 ‐0.80167 ‐0.1233333 0.0983333 0.52 ‐0.04667 0.258333 0.273333 0.022539352 ‐0.609444445 4542 MYO1F ‐0.05 ‐0.825 ‐0.545 0.26 0 ‐0.37 0.44 0.36 0.125 0.033014279 ‐0.609166667 83742 MARVELD1 ‐0.94 ‐0.59 ‐0.24 0 0.04 ‐0.25 0 0.26 0.06 0.007646804 ‐0.608333333 7789 ZXDA ‐0.1327 ‐0.30181 ‐1.09556 0.2344444 0.3061111 ‐0.27555556 0.124444 0 0.194444 0.034179913 ‐0.607334656 84681 HINT2 ‐0.63 0 ‐1.18 0.02 0.13 0.17 ‐0.16 0.14 ‐0.28 0.044901237 ‐0.606666667 57415 C3orf14 0 ‐0.14 ‐1.03 0.47 ‐0.03 0.09 0.11 0.35 0.3 0.039303875 ‐0.605 51145 LOC51145 ‐0.2806 ‐0.07917 ‐0.67917 0.1908333 0.1508333 0 0.153611 0.760833 0.290833 0.017474696 ‐0.604133598 8815 BANF1 ‐0.56 0.245 ‐0.88 0.27 0.24 0.49 ‐0.02 0.14 0.11 0.041653706 ‐0.603333333 11180 WDR6 ‐0.19 ‐0.21667 ‐0.65667 0.7066667 0.0883333 0.08333333 0.536667 0 0.073333 0.020773217 ‐0.6025 81603 TRIM8 ‐0.445 ‐0.14 ‐0.93 0.05 0.075 0.03 0.34 ‐0.06 0.15 0.009782388 ‐0.6025 8612 PPAP2C ‐0.38 ‐0.17 ‐0.57 0.48 ‐0.03 0.18 0.58 0.12 0.03 0.008648985 ‐0.6 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 55852 TEX2 ‐0.58 ‐0.07 ‐0.93 ‐0.03 0.1 0.04 0.17 0.08 0.07 0.009246073 ‐0.598333333 64285 RHBDF1 0.025 ‐0.485 ‐1.05 0.39 0.15 0 0.145 ‐0.25 0.125 0.041211884 ‐0.596666667 55647 RAB20 ‐0.135 ‐0.45 ‐0.805 0 0.145 0.08 0.49 0.115 ‐0.035 0.009740139 ‐0.595833333 54964 C1orf56 ‐0.68 ‐0.75333 ‐0.19667 0.1366667 ‐0.02 ‐0.00333333 0.023333 0.173333 0 0.002004419 ‐0.595 9014 TAF1B ‐0.84 ‐0.47 ‐0.67 ‐0.32 0.24 0.05 ‐0.5 0.14 0 0.014470856 ‐0.595 28978 TMEM14A ‐0.13 ‐0.05 ‐0.42 0.14 0.84 0.34 0.35 0.26 0.43 0.007827863 ‐0.593333333 158234 RG9MTD3 ‐0.615 0.105 ‐0.84 ‐0.235 0.35 0.195 0 0.265 0.285 0.035627344 ‐0.593333333 8738 CRADD ‐0.865 ‐0.52 ‐0.5 ‐0.34 0.04 ‐0.025 0.125 0.01 ‐0.03 0.001912515 ‐0.591666667 79161 C7orf23 ‐0.35 ‐1.12 ‐0.31 0.21 ‐0.26 ‐0.2 0.42 ‐0.12 ‐0.06 0.038975602 ‐0.591666667 4969 OGN ‐0.01183 ‐0.44183 ‐0.61183 0.5575333 ‐0.0618333 0 0.658167 0.218167 0.028167 0.03024039 ‐0.588533333 7942 TFEB ‐0.395 ‐0.045 ‐0.51 ‐0.115 0.11 0.335 0.36 0.41 0.53 0.009701091 ‐0.588333333 11137 PWP1 ‐1.065 ‐0.76 ‐0.07 ‐0.29 0 ‐0.065 ‐0.115 0.185 0.025 0.028863568 ‐0.588333333 55335 NIPSNAP3B ‐0.68 0.08 ‐0.695 0.68 ‐0.03 0.205 0.145 ‐0.06 0 0.041007218 ‐0.588333333 112401 BIRC8 ‐0.25875 ‐0.26292 ‐1.14 ‐0.01 0.095 0.26 ‐0.29 0 0.143 0.033252829 ‐0.586888889 93556 C3orf50 ‐0.30633 ‐0.66633 ‐0.42633 0.1636667 0.2036667 0.15366667 ‐0.02633 0.170704 0.053667 0.000265375 ‐0.58617284 3718 JAK3 ‐0.38 ‐0.83667 ‐0.01083 0.3166667 ‐0.0433333 ‐0.09083333 0 0.663333 0.206667 0.039556577 ‐0.584583334 55315 SLC29A3 ‐1.24 ‐0.195 ‐0.335 0.14 ‐0.275 ‐0.125 0.1 0.03 0.095 0.041947837 ‐0.584166667 84641 HIATL1 ‐0.57333 ‐0.28333 ‐0.59333 0.23 0.1033333 0.07 ‐0.17667 0.443333 ‐0.07 0.005350466 ‐0.583333333 29950 SERTAD1 ‐0.64 0.025 ‐1.115 ‐0.12 ‐0.26 0.075 0 0.235 0.105 0.045926668 ‐0.5825 9166 EBAG9 ‐0.7 ‐0.165 ‐0.77 0.005 0.305 0.17 ‐0.515 0.34 ‐0.095 0.03802772 ‐0.58 51088 KLHL5 ‐0.12667 ‐0.2025 ‐1.04 0.4975 0 0.11333333 0.075 ‐0.005 0.056667 0.035166877 ‐0.579305556 8242 KDM5C ‐1.1 1.39E‐17 ‐0.44333 ‐0.14 0.2666667 0.07666667 ‐0.20667 0.233333 0.15 0.046783974 ‐0.577777778 4638 MYLK ‐0.44333 ‐0.49667 ‐0.655 0.3633333 0.3266667 ‐0.15333333 ‐0.05333 0 ‐0.21333 0.00672852 ‐0.576666667 5007 OSBP ‐0.635 ‐0.26 ‐0.41 0.085 0.085 0.29 0.32 ‐0.08 0.15 0.001437281 ‐0.576666667 58986 TMEM8A ‐0.45 ‐0.19 ‐0.74 ‐0.08 0.13 0.32 0.58 0 ‐0.25 0.026569553 ‐0.576666667 84671 ZNF347 ‐0.24667 0.106667 ‐0.73 0.61 0.31 0.38666667 ‐0.13 0 0.54 0.045519432 ‐0.576111111 64132 XYLT2 ‐0.36 ‐0.57 ‐0.70.160.21‐0.41 0.27 0 ‐0.04 0.009214765 ‐0.575 2195 FAT1 ‐0.25667 ‐0.10667 ‐0.81667 0.5133333 0.4366667 0.07666667 0.036667 0 0.016667 0.022999408 ‐0.573333334 7050 TGIF1 ‐0.14 ‐0.2 ‐0.5 ‐0.215 0.385 0.315 0.405 0.465 0.405 0.011309113 ‐0.573333333 10903 MTMR11 ‐0.5 ‐0.36 ‐0.37 0.13 0.36 0.09 0.27 0.02 0.11 0.000199292 ‐0.573333333 10567 RABAC1 ‐0.54 ‐0.2 ‐0.37 ‐0.18 0.46 0.28 0.25 0.24 0.17 0.004896153 ‐0.573333333 10613 ERLIN1 ‐0.225 ‐0.32 ‐0.645 0.43 0.265 ‐0.005 0 0.27 0.095 0.003582616 ‐0.5725 10475 TRIM38 ‐0.57 ‐0.035 ‐0.48 0.4 0 0.55 0.105 0.305 ‐0.095 0.016969405 ‐0.5725 3992 FADS1 0.105 ‐0.3 ‐0.705 0.365 0 0.095 0.815 0.19 0.17 0.043025881 ‐0.5725 84186 ZCCHC7 ‐0.97667 ‐0.1 ‐0.48333 0.1166667 0.2 ‐0.1 ‐0.11 0.196667 0 0.018211747 ‐0.570555556 2794 GNL1 ‐0.28 ‐0.325 ‐0.845 0.035 ‐0.15 0.415 0.175 ‐0.03 0.07 0.010978084 ‐0.569166667 374920 C19orf68 ‐0.5 0 ‐0.49 0.2 0.36 0.24 0.1 0.18 0.35 0.002515182 ‐0.568333333 3156 HMGCR ‐0.215 ‐0.88 ‐0.38 0.01 0 ‐0.065 0.33 0.245 ‐0.06 0.010788594 ‐0.568333333 6275 S100A4 ‐0.08 ‐0.16 ‐0.87 0.13 0.42 0.19 0.33 0.12 0 0.019308624 ‐0.568333333 84912 SLC35B4 ‐0.30333 ‐0.69667 ‐0.23333 0.7666667 ‐0.04 0 0.066667 0.113333 0.03 0.02760529 ‐0.567222222 26035 GLCE ‐0.38 0 ‐0.68 0.26 0.6 0.26 ‐0.08 0.13 0.11 0.019125951 ‐0.566666667 5335 PLCG1 ‐0.24 0.06 ‐0.93 0.36 0.3 0.07 ‐0.05 0.34 0.16 0.034071794 ‐0.566666667 23179 RGL1 ‐0.65 ‐0.08 ‐0.29 ‐0.06 0.26 0.32 0 0.4 0.43 0.011057916 ‐0.565 55229 PANK4 ‐0.39 ‐0.35 ‐0.33 0.56 0.01 ‐0.06 0.55 0.18 0 0.012386909 ‐0.563333333 92703 TMEM183A ‐0.87 ‐0.19 ‐0.32 0.11 ‐0.2 0.18 0.46 0.07 0 0.020276239 ‐0.563333333 55332 DRAM1 ‐0.655 ‐0.195 ‐0.6775 0 0.0225 0.3125 ‐0.075 0.0825 ‐0.02 0.00364699 ‐0.562916667 89870 TRIM15 ‐0.69 ‐0.125 ‐0.3925 0 0.155 0.375 0.28 0.11 0.04 0.004546119 ‐0.5625 10717 AP4B1 ‐0.77 ‐0.17 ‐0.37 ‐0.05 0.39 0.08 0.17 ‐0.02 0.18 0.007255291 ‐0.561666667 200058 FLJ23867 ‐0.22 ‐0.22 ‐0.96 ‐0.13 0.33 0.29 0.02 ‐0.15 0.21 0.028873139 ‐0.561666667 126767 AADACL3 ‐0.27188 ‐0.09 ‐1.08 0.11 0.2475926 0.12 0.07 ‐0.03 ‐0.04429 0.031884965 ‐0.55950948 204851 HIPK1 ‐0.3725 ‐0.2825 ‐0.4475 0 0.0325 0.2225 0.2275 0.415 0.2525 0.00068505 ‐0.559166667 83953 FCAMR ‐0.28875 ‐0.2 ‐0.71 0.44 0.55 ‐0.19 0 0.184074 ‐0.03 0.0271543 ‐0.558595679 79083 MLPH ‐0.088 ‐0.276 ‐0.854 0.134 0.064 0.2515 0.104 0.104 0.258 0.009726992 ‐0.558583333 535 ATP6V0A1 ‐0.33 ‐0.645 ‐0.53 ‐0.04 ‐0.0666667 ‐0.21 0.465 0.096667 0.086667 0.007566787 ‐0.556944445 9851 KIAA0753 ‐0.39 ‐0.35 ‐0.87 0.16 0.05 ‐0.11 0 0.07 ‐0.05 0.002743351 ‐0.556666667 51098 IFT52 ‐0.305 ‐0.275 ‐0.995 0.145 0.085 0.125 ‐0.165 ‐0.005 0 0.013123642 ‐0.555833333 90135 BTBD6 ‐0.41 ‐0.21 ‐0.39 0.18 0.25 0.19 0 0.44 0.25 0.000620851 ‐0.555 51063 CALHM2 ‐0.43 ‐0.29 ‐0.47 ‐0.27 ‐0.03 0.24 0.37 0.64 0 0.026069969 ‐0.555 5218 CDK14 0 ‐0.695 ‐0.27 0.585 0.21 0.16 0.435 ‐0.12 0.13 0.026646133 ‐0.555 9986 RCE1 ‐0.38 ‐0.36 ‐0.84 0.305 0 0.11 ‐0.35 0.025 0.07 0.01184158 ‐0.553333333 95681 TSGA14 ‐0.2 ‐0.14667 ‐0.44 0.6433333 0.5466667 0.3 0 0.226667 0.01 0.014468151 ‐0.55 4835 NQO2 ‐0.09 ‐0.43 ‐0.63 0.49 0 0.31 0.38 0.05 ‐0.23 0.024399994 ‐0.55 23430 TPSD1 ‐0.12007 ‐0.22 ‐0.37806 0.28 0.54 0.0562 ‐0.08 0.35 0.715 0.019938013 ‐0.549574074 10081 PDCD7 ‐0.655 ‐0.26 ‐0.605 0.35 ‐0.03 0.04 ‐0.395 ‐2.34E‐17 0.28 0.017776904 ‐0.5475 55776 C6orf64 ‐0.50333 ‐0.18 ‐0.82667 0.0833333 0.19 ‐0.02 0.15 0 ‐0.14 0.006305785 ‐0.547222222 81847 RNF146 ‐0.37 0.03 ‐0.75 0 0.33 0.17 0.21 0.35 0.04 0.015067746 ‐0.546666667 57171 DOLPP1 ‐0.735 ‐0.205 ‐0.365 0.235 0.135 ‐0.005 0 0.22 0.075 0.002701882 ‐0.545 23164 MPRIP ‐0.23 ‐0.605 ‐0.455 0.365 ‐0.26 0.16 0.52 ‐0.085 ‐0.02 0.023685834 ‐0.543333333 10244 RABEPK ‐0.975 ‐0.445 ‐0.35 ‐0.465 ‐0.26 0.045 ‐0.04 0.31 0.125 0.035753038 ‐0.5425 3219 HOXB9 ‐0.64 ‐0.68 ‐0.06 ‐0.22 0.19 0 0 0.17 0.35 0.018144057 ‐0.541666667 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 9064 MAP3K6 ‐0.41667 ‐0.45333 ‐0.34 0.5166667 ‐0.0666667 0.12 0.076667 0.05 0.133333 0.002834542 ‐0.541666667 253827 MSRB3 ‐0.39 ‐0.5 ‐0.72 ‐0.2 0.29 ‐0.04 0.13 0.01 ‐0.16 0.003671757 ‐0.541666667 55723 ASF1B ‐0.405 ‐0.245 ‐0.41 0.19 0.13 0.475 0.375 ‐0.095 0.055 0.004183527 ‐0.541666667 54491 FAM105A ‐0.29 ‐0.39 ‐0.71 0 0.24 0.11 0.31 ‐0.29 0.1 0.008899402 ‐0.541666667 1605 DAG1 ‐0.24 ‐0.165 ‐0.7 0.125 ‐0.24 0 0.605 0.27 0.275 0.032283625 ‐0.540833333 124976 SPNS2 ‐0.67 ‐0.355 ‐0.175 ‐0.295 0.275 0.295 0 0.245 0.325 0.016948448 ‐0.540833333 1638 DCT ‐0.42167 ‐0.09667 ‐0.79 ‐0.0066667 0 0.18833333 0.16 0.143333 0.130833 0.006412645 ‐0.53875 91304 C19orf6 ‐0.3 ‐0.33 ‐0.615 0.37 0.25 ‐0.02 0.195 0 ‐0.06 0.003275679 ‐0.5375 51716 CES4 ‐1.11 ‐0.32388 ‐0.17 ‐0.2691111 0.05 0.16 ‐0.22 0.1361 0.16 0.047386334 ‐0.537456482 55733 HHAT ‐0.63 0 ‐0.36 0.29 0.5 0 ‐0.12 0.31 0.26 0.020675551 ‐0.536666667 23586 DDX58 0.003333 ‐0.14 ‐0.885 0.23 0.165 0.14 ‐0.095 0.505 0.223333 0.040903949 ‐0.535277778 9019 MPZL1 ‐0.432 ‐0.446 ‐0.476 ‐0.234 0.206 ‐0.2045 0.18 0.348 0.204 0.007738798 ‐0.534583333 29995 LMCD1 ‐0.19 ‐0.26 ‐0.5 0.05 0.47 0.55 0 0.17 0.06 0.010323054 ‐0.533333333 253461 ZBTB38 ‐0.075 ‐0.235 ‐0.785 0.4 0.01 ‐0.165 0.49 0.185 0.085 0.034366382 ‐0.5325 4758 NEU1 ‐0.5 0.07 ‐0.935 0.065 ‐0.005 ‐0.095 0.22 0.235 0.04 0.036099325 ‐0.531666667 80149 ZC3H12A ‐0.29 ‐0.2 ‐0.62 ‐0.125 ‐0.02 0 0.42 0.21 0.485 0.017407939 ‐0.531666667 9859 CEP170 ‐0.565 ‐0.163 ‐0.4375 0 0.017 0.041 0.3125 0.303 0.185 0.002493738 ‐0.531583333 493 ATP2B4 ‐1.03 ‐0.04 ‐0.3 0 ‐0.02 ‐0.075 0.125 0.183333 0.235 0.037625566 ‐0.531388889 84879 MFSD2A ‐0.32 ‐0.085 ‐0.28 0 0.35 0.42 0.095 0.395 0.555 0.005627118 ‐0.530833333 55568 GALNT10 ‐0.08 ‐0.06667 ‐0.73333 0.0236667 0.4816667 0.29 ‐0.16233 0.386667 0.405 0.038361209 ‐0.530777778 3906 LALBA ‐0.3187 ‐0.2426 ‐1.01833 ‐0.31 0 ‐0.02 0.12 0.199444 0.027 0.028332092 ‐0.529287809 64601 VPS16 ‐0.105 ‐0.35 ‐0.565 0.59 0.14 0.09 0.3 0.125 ‐0.11 0.015235393 ‐0.529166667 136647 C7orf11 ‐0.915 ‐0.72 ‐0.185 ‐0.33 0 ‐0.205 ‐0.19 0.12 0.13 0.023318043 ‐0.5275 7916 BAT2 ‐0.3 0.15 ‐0.955 0 0.245 0.175 0.175 0.11 0.25 0.045625195 ‐0.5275 51447 IP6K2 ‐0.41667 ‐0.18 ‐0.69833 0.3133333 0.085 ‐0.18 0.206667 0.073333 0.068333 0.006924226 ‐0.526111111 9308 CD83 ‐0.46 ‐0.29 ‐0.59 0.26 ‐0.01 0.17 ‐0.02 ‐0.06 0.13 0.000873537 ‐0.525 51706 CYB5R1 ‐0.03 ‐0.66 ‐0.66 0.21 0.24 ‐0.05 0.255 0 ‐0.21 0.021703913 ‐0.524166667 9563 H6PD ‐1.02 ‐0.50333 ‐0.02 0.02 0.02 ‐0.16 0.116667 0.01 0.05 0.032375688 ‐0.523888889 2593 GAMT ‐0.365 0.03 ‐0.73 0.145 0.145 0.585 0 0.1 0.03 0.029672502 ‐0.5225 147372 CCBE1 ‐0.19857 ‐0.23857 ‐0.15857 0.3414286 0.5314286 0.35142857 0 0.391429 0.321429 0.001700108 ‐0.521428572 5026 P2RX5 ‐0.59667 ‐0.1275 ‐0.7 ‐0.04 ‐0.2175 0 0.24 0.1525 0.1425 0.011020322 ‐0.520972222 5908 RAP1B ‐0.34 ‐0.525 ‐0.18 0.245 0.155 0 0.37 0.185 0.08 0.001309959 ‐0.520833333 9609 RAB36 ‐0.515 ‐0.73 ‐0.055 0.07 0.065 ‐0.095 ‐0.085 0.33 0.24 0.016246202 ‐0.520833333 83692 CD99L2 ‐0.07333 ‐0.25333 ‐0.84667 0.1366667 0.2566667 0 0.253333 0.06 0.066667 0.016439983 ‐0.52 56910 STARD7 ‐0.89 ‐0.6 ‐0.2 0.31 ‐0.16 ‐0.195 0.055 ‐0.2 ‐0.07 0.021556411 ‐0.52 8985 PLOD3 ‐0.11 ‐0.2 ‐0.95 0.25 ‐0.03 0 0.27 0.03 0.08 0.02945985 ‐0.52 89796 NAV1 0 ‐0.58583 ‐0.1925 0.1275 0.3708333 0.1525 0.1225 0.5575 0.2325 0.011475834 ‐0.52 55861 DBNDD2 ‐0.14 ‐0.33333 ‐0.71833 0 0.1416667 0.09166667 ‐0.05667 0.246667 0.301667 0.007306893 ‐0.518055556 201626 PDE12 ‐0.32 ‐0.565 ‐0.275 0.135 0.0483333 ‐0.015 0.2 0.505 ‐0.09167 0.00750638 ‐0.516944444 63905 MANBAL ‐0.245 ‐0.295 ‐0.63 0 0 0.28 0 0.18 0.3 0.003119661 ‐0.516666667 26020 LRP10 ‐0.0175 ‐0.2125 ‐0.9125 ‐0.13 0.315 0.03 0.349167 0.0375 0.2125 0.043568979 ‐0.516527778 94137 RP1L1 ‐0.34857 ‐0.27688 ‐1.02583 ‐0.22375 0.02 0.06 0 0 ‐0.06 0.017686263 ‐0.516468254 2629 GBA ‐0.285 ‐0.045 ‐0.88 0.32 0.115 0.22 0.08 0.145 ‐0.205 0.032547125 ‐0.515833333 9488 PIGB ‐0.41 ‐0.38 ‐0.37 0.26 0 0.25 0.22 0 0.04 0.000271625 ‐0.515 283212 KLHL35 ‐0.26 ‐0.3 ‐0.42 0.53 0.14 0.1 ‐0.09 0.21 0.24 0.004597666 ‐0.515 5612 PRKRIR ‐0.22 ‐0.54 ‐0.35 0.68 0.11 0.12 ‐0.06 ‐0.11 0.12 0.02395375 ‐0.513333333 1861 TOR1A ‐0.18 ‐0.345 ‐0.33 0.34 ‐0.12 0.16 0.76 0.23 0 0.028748893 ‐0.513333333 136319 MTPN ‐0.52 ‐0.1175 ‐0.955 0.13 0 0.0525 ‐0.2525 0.048333 ‐0.085 0.02339591 ‐0.513055556 480 ATP1A4 0 ‐0.24333 ‐0.51667 0.55 0.2433333 0.465 0.355 ‐0.00333 ‐0.055 0.023026754 ‐0.5125 283464 GXYLT1 ‐0.365 ‐0.095 ‐0.505 0.05 0.385 0 0.075 0.27 0.365 0.005248332 ‐0.5125 54490 UGT2B28 ‐0.28 ‐0.10667 ‐1.05667 ‐0.05 0.05 0 0.035556 0.2 ‐0.05 0.036909761 ‐0.512037037 6804 STX1A ‐0.2175 0.008 ‐0.526 0.17 0.518 0.254 ‐0.036 0.318 0.37 0.01188891 ‐0.510833333 9693 RAPGEF2 ‐0.76 ‐0.55 ‐0.1 ‐0.11 0.35 0.28 ‐0.33 0.11 ‐0.06 0.037522137 ‐0.51 10507 SEMA4D ‐0.1025 ‐0.405 ‐0.5975 0.4475 0.0825 ‐0.2775 0.52 0.065 0 0.039499356 ‐0.507916667 79143 MBOAT7 ‐0.12667 0 ‐0.88 0.11 0.22 0.28 0.22 0.016667 0.186667 0.030874792 ‐0.507777778 790 CAD ‐0.935 ‐0.57 ‐0.135 0.135 ‐0.31 ‐0.06 0.2 ‐0.105 ‐0.105 0.030567168 ‐0.505833333 116496 FAM129A ‐0.24 ‐0.175 ‐0.69 0.2975 0.3475 0.0125 0.0375 ‐0.085 0.21 0.011318107 ‐0.505 8477 GPR65 ‐0.23111 ‐0.13 ‐1.03146 ‐0.04 0.03 0.02 0.073833 0.127 0.0255 0.032699531 ‐0.503578704 4800 NFYA ‐0.17 ‐0.31 ‐0.69 0.14 0.24 0 0.1 0.18 0.02 0.003368833 ‐0.503333333 965 CD58 0 ‐0.25 ‐0.86 0.2 0.28 ‐0.09 ‐0.05 0.35 0.11 0.03847821 ‐0.503333333 1665 DHX15 ‐0.09 ‐0.835 ‐0.325 0.235 ‐0.035 0 0.465 0.065 ‐0.215 0.041446552 ‐0.5025 11100 HNRNPUL1 0.096667 ‐0.39333 ‐0.25333 0.54 0.48 0.54 0.475 ‐0.12 0 0.041550656 ‐0.5025 51557 LGSN ‐0.01643 ‐0.63 ‐0.47 0 0.02 0.03 0.03 0.15 0.55 0.023972703 ‐0.502142857 2734 GLG1 ‐0.47 ‐0.13 ‐0.52 0.34 0.31 0.145 ‐0.005 ‐0.03 0.01 0.005481266 ‐0.501666667 7171 TPM4 ‐0.238 ‐0.122 ‐0.688 0.148 0.176 0.178 0.176 0.238 ‐0.004 0.0047451 ‐0.501333333 79586 CHPF ‐0.345 ‐0.04 ‐0.885 0.1 ‐0.245 0.105 0.32 0 0.185 0.039131449 ‐0.500833333 64215 DNAJC1 ‐0.43 ‐0.1 ‐0.58 0.16 0.22 0.23 ‐0.24 0.13 0.28 0.011114895 ‐0.5 3675 ITGA3 ‐0.07333 ‐0.19667 ‐1.03 0.0366667 0.0566667 0.08 0.06 ‐0.03333 0.196667 0.042471888 ‐0.499444445 6553 SLC9A5 ‐0.55 ‐0.33 ‐0.57 0.07 0 0 ‐0.01 0 0.03 3.3943E‐05 ‐0.498333333 8692 HYAL2 ‐0.38 0 ‐0.63 0.39 ‐0.13 0.23 0.36 0.12 0 0.022635942 ‐0.498333333 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 133 ADM ‐0.13333 ‐0.31667 ‐0.23667 ‐0.0233333 0.0133333 ‐0.02666667 0.673333 0.46 0.516667 0.035854962 ‐0.497777778 164284 APCDD1L ‐0.1 ‐0.19 ‐0.83 0 0.2 ‐0.06 0.15 0.44 0.01 0.03212312 ‐0.496666667 130574 LYPD6 ‐0.362 ‐0.2855 ‐0.6405 ‐0.112 0.436 0.144 ‐0.18 0.004 0.1045 0.012633084 ‐0.495416667 1509 CTSD ‐0.04 0 ‐0.61333 0.26 0.33 0.20666667 0.256667 0.276667 0.33 0.007414309 ‐0.494444445 4299 AFF1 ‐0.42786 ‐0.13143 ‐0.61952 ‐0.1611905 0.1871429 0.09571429 0.08381 0.244286 0.157143 0.005664953 ‐0.494087302 3192 HNRNPU ‐0.938 ‐0.464 ‐0.094 0 0.102 0.2 ‐0.192 ‐0.142 0.004 0.030209711 ‐0.494 9374 PPT2 ‐0.88 ‐0.20333 ‐0.61667 ‐0.4933333 0.04 ‐0.14666667 0.056667 0.05 0.056667 0.031649697 ‐0.493888889 55032 SLC35A5 0.05 ‐0.47 ‐0.68 0.36 0.18 0.22 0.23 ‐0.3 0.07 0.04088687 ‐0.493333333 79033 ERI3 ‐0.465 ‐0.225 ‐0.63 ‐0.38 0.045 0.005 0 0.06 0.59 0.04360371 ‐0.493333333 9962 SLC23A2 ‐0.34 ‐0.17 ‐0.77667 0.02 0.055 0.12 0.05 0.14 ‐0.00333 0.005146131 ‐0.4925 10749 KIF1C ‐0.52 ‐0.03 ‐0.66 ‐0.09 0.16 0.13 0.15 0.13 0.05 0.00901598 ‐0.491666667 56 ACRV1 ‐0.37 ‐0.435 ‐0.70167 ‐0.39 0.095 ‐0.1 0.15 0.099375 0.08 0.009580217 ‐0.491284722 10042 HMGXB4 ‐0.78 ‐0.08 ‐0.14 0.2 0 ‐0.07 0.19 0.15 0.47 0.03288063 ‐0.49 51538 ZCCHC17 ‐0.72333 ‐0.21333 ‐0.58333 ‐0.2566667 0 0.12 ‐0.28 0.163333 0.146667 0.016853316 ‐0.488888889 54778 RNF111 ‐0.32 ‐0.37 ‐0.51 0.28 0.03 ‐0.12 0.32 ‐0.2 0.22 0.008697338 ‐0.488333333 6385 SDC4 ‐0.15333 ‐0.41 ‐0.93333 0 0.19 ‐0.40666667 ‐0.01 0.073333 0.083333 0.040624797 ‐0.487222222 6618 SNAPC2 ‐0.81 0 ‐0.38 0.04 0.01 0.1 ‐0.02 0.33 0.08 0.024570055 ‐0.486666667 54665 RSBN1 ‐0.25 ‐0.52 ‐0.38 0.07 0.19 0.09 ‐0.01 0.27 0.01 0.000587287 ‐0.486666667 353131 LCE1A ‐0.35 ‐0.56 ‐0.66 0.01 0.06 0 0.16 ‐0.26 ‐0.19 0.00334309 ‐0.486666667 91663 MYADM ‐0.31 ‐0.22 ‐0.41 0.075 0.525 0.015 ‐0.28 0.1 0.6 0.046841136 ‐0.485833333 55030 FBXO34 ‐0.53667 ‐0.15333 ‐0.35333 0.4516667 0.22 ‐0.03333333 0 0.096667 0.09 0.006914272 ‐0.485277778 1729 DIAPH1 ‐0.415 ‐0.23 ‐0.555 0.255 0.055 0.17 ‐0.025 0.015 0.04 0.000914698 ‐0.485 29954 POMT2 ‐0.205 ‐0.335 ‐0.67 0.525 ‐0.08 0.045 ‐0.075 0.085 ‐0.01 0.020662972 ‐0.485 4237 MFAP2 ‐0.195 ‐0.25 ‐0.55 ‐0.115 0.34 0.385 ‐0.125 0.04 0.39 0.021733508 ‐0.484166667 54497 HEATR5B ‐0.52 ‐0.04 ‐0.42 0 ‐0.09 0.12 0.74 ‐0.01 0.18 0.049803669 ‐0.483333333 5818 PVRL1 ‐0.31333 ‐0.34 ‐0.45 0.3066667 ‐0.03 0 0.31 0.166667 ‐0.06333 0.002474178 ‐0.482777778 55034 MOCOS ‐0.35 ‐0.18 ‐0.38 0.19 ‐0.07 0.03 0.47 0.14 0.31 0.005720114 ‐0.481666667 79796 ALG9 ‐0.645 ‐0.01 ‐0.4 ‐0.16 0.26 0.11 0.31 0.145 0.09 0.018292618 ‐0.4775 348793 WDR53 ‐0.42 ‐0.26 ‐0.14 0.22 ‐0.03 0.3 0.38 0.15 0.2 0.001948091 ‐0.476666667 4841 NONO ‐0.5125 ‐0.22 ‐0.505 0.065 0.07 0.275 ‐0.0375 ‐0.06 0.0725 0.001520025 ‐0.476666667 23220 DTX4 ‐0.43 ‐0.48 ‐0.08 0.345 0.085 ‐0.08 0.185 0.185 0.155 0.004823594 ‐0.475833333 57045 TWSG1 ‐0.21667 ‐0.36 ‐0.66667 0.15 0.0666667 0 ‐0.17 0.023333 0.28 0.006974949 ‐0.472777778 57513 CASKIN2 ‐0.27917 ‐0.0025 ‐0.26583 ‐0.0425 0.4075 0.5575 0.0875 0.2475 0.48 0.017189046 ‐0.472083333 63898 SH2D4A 0 ‐0.01 ‐0.40667 0.7166667 ‐0.12 0.37666667 0.49 0.206667 0.326667 0.041631281 ‐0.471666667 51296 SLC15A3 ‐0.45 ‐0.00667 ‐0.62333 0.1033333 0.2066667 0.06 0.046667 0.16 0.093333 0.007126011 ‐0.471666667 85444 LRRCC1 ‐0.33 ‐0.185 ‐0.14 0.405 0.21 0.2 0.57 ‐0.125 0.26 0.013634664 ‐0.471666667 9842 PLEKHM1 ‐0.31 ‐0.59667 ‐0.46333 ‐0.2 0.0966667 0.00666667 0.05 0.056667 0.076667 0.000860046 ‐0.471111111 84818 IL17RC ‐0.11 ‐0.03 ‐0.9 0.18 0.04 0.015 0.21 0 0.3 0.047384183 ‐0.470833333 2937 GSS ‐0.24 ‐0.24 ‐0.61 0.25 0.08 0.21 ‐0.02 0.12 0 0.00270432 ‐0.47 5971 RELB ‐0.34 ‐0.14 ‐0.78 0.09 ‐0.08 0.08 0.06 0.15 0 0.009434892 ‐0.47 84058 WDR54 ‐0.43 ‐0.17 ‐0.41 ‐0.08 0.325 0.365 ‐0.115 0.165 0.135 0.008976955 ‐0.469166667 3732 CD82 ‐0.39 ‐0.03 ‐0.79 ‐0.1 0.19 0.04 0.09 0.07 0.09 0.019325346 ‐0.466666667 2954 GSTZ1 ‐0.44 ‐0.14 ‐0.14 0.48 0.14 0.32 0.63 ‐0.07 ‐0.15 0.048647486 ‐0.465 200315 APOBEC3A ‐0.05 ‐0.08 ‐0.445 0.335 0.37 0.265 0.095 0.17 0.4 0.003880786 ‐0.464166667 5376 PMP22 ‐0.3 ‐0.17 ‐0.61333 ‐0.0633333 0.1566667 0 0.196667 0.19 0.136667 0.003541731 ‐0.463888889 64866 CDCP1 ‐0.27 ‐0.14167 ‐0.47667 ‐0.1666667 0.5033333 0.22333333 ‐0.06333 0.276667 0.233333 0.022458552 ‐0.463888889 80128 TRIM46 ‐0.24 ‐0.01 ‐0.335 0.27 0.405 0.185 0 0.445 0.3 0.005085934 ‐0.4625 9031 BAZ1B ‐0.11 ‐0.14 ‐0.13 0.5 0.24 0.54 0.35 0.1 0.26 0.002521439 ‐0.458333333 92840 REEP6 ‐0.4 ‐0.07 ‐0.63 0.05 0.49 0.19 ‐0.18 0.11 ‐0.11 0.036708974 ‐0.458333333 154141 MBOAT1 ‐0.66 ‐0.06 0 0.04 0.4 0.13 ‐0.03 0.45 0.32 0.040058861 ‐0.458333333 9466 IL27RA ‐0.935 ‐0.3 ‐0.46 ‐0.255 ‐0.29 ‐0.33 0 0.13 0.1 0.035465848 ‐0.4575 1182 CLCN3 ‐0.53 ‐0.69 ‐0.06 ‐0.24 0.205 0.03 ‐0.11 0.36 ‐0.06 0.03872592 ‐0.4575 3607 FOXK2 ‐0.22333 ‐0.54333 ‐0.12333 0.2133333 0.0333333 0.43333333 0.225 0.056667 0 0.009192624 ‐0.456944444 10312 TCIRG1 ‐0.17 ‐0.16 ‐0.37 0.57 0.09 0.36 0.22 ‐0.01 0.11 0.011383566 ‐0.456666667 50814 NSDHL ‐0.185 ‐0.205 ‐0.595 0.06 0.09 0.095 0.52 0.075 ‐0.07 0.018057751 ‐0.456666667 5872 RAB13 ‐0.13 0.04 ‐0.68 0.4 0.31 0.11 0.11 0.27 0 0.030038387 ‐0.456666667 11190 CEP250 ‐0.21 0.015 ‐0.73 0.095 0.035 0.515 0.14 0.215 ‐0.11 0.048544876 ‐0.456666667 10362 HMG20B ‐0.57 0.04 ‐0.56 0.13 ‐0.05 0.07 0.38 0 0.01 0.026129985 ‐0.453333333 55129 ANO10 ‐0.03467 ‐0.20467 ‐0.43467 0.0353333 0.2053333 0.28533333 0.725333 ‐0.09467 0.205333 0.043720449 ‐0.451666667 3397 ID1 ‐0.215 ‐0.13 ‐0.305 0.635 ‐0.005 0.315 0.415 ‐0.125 0.175 0.032664452 ‐0.451666667 55701 FLJ10357 ‐0.19333 ‐0.11333 ‐0.63333 0.01 0.45 0.1 0 0.27 ‐0.00333 0.021548921 ‐0.451111111 390940 LOC390940 ‐0.29 ‐0.04 ‐0.59 0 ‐0.1 0.04 0.21 0.13 0.58 0.038333729 ‐0.45 4857 NOVA1 ‐0.69 ‐0.155 ‐0.435 0.16 ‐0.375 0.04 0 0.235 0.075 0.027805088 ‐0.449166667 11107 PRDM5 ‐0.35833 ‐0.135 ‐0.545 0 0.2516667 ‐0.09166667 0.02 0.031667 0.405 0.013007629 ‐0.448888889 8651 SOCS1 ‐0.19667 0.086667 ‐0.69667 0.06 0.1 0.29 0 0.26 0.366667 0.036215518 ‐0.448333334 3745 KCNB1 ‐0.81 ‐0.32 0.08 0.225 0.2 0.18944444 ‐0.015 ‐0.115 0.105 0.047832278 ‐0.448240741 51255 RNF181 ‐0.31 ‐0.07 ‐0.66 ‐0.07 0.09 0.21 0.29 0 0.08 0.01396497 ‐0.446666667 9401 RECQL4 ‐0.28 0.02 ‐0.13 0.49 0.37 0.6 0 0 0.44 0.02920899 ‐0.446666667 118429 ANTXR2 0 ‐0.075 ‐0.7075 0.0125 0.3283333 0.25 0.275 0.131667 0.11 0.029415319 ‐0.445416667 59347 FKSG2 ‐0.5 0 ‐0.19 0.09 0.19 0.19 0.17 0.34 0.31 0.005014385 ‐0.445 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 23682 RAB38 ‐0.22667 0.083333 ‐0.60667 0.0766667 0.1033333 0.34333333 0.508333 0.196667 ‐0.06 0.041578263 ‐0.444722223 4142 MAS1 ‐0.65333 ‐0.045 ‐0.34146 0.1133333 0.0766667 0.04666667 0.126667 0.216667 0.006667 0.00857632 ‐0.444375 57798 GATAD1 ‐0.76 ‐0.205 ‐0.265 ‐0.075 0.37 0.075 ‐0.075 0 ‐0.095 0.02512352 ‐0.443333333 9435 CHST2 ‐0.295 0 ‐0.73 0.05 0.005 ‐0.16 0.4 0.245 0.065 0.044871286 ‐0.4425 79720 VPS37B ‐0.36 ‐0.1 ‐0.54 0.035 0.115 0.11 0.06 0 0.33 0.004871006 ‐0.441666667 135398 C6orf141 ‐0.125 ‐0.36 ‐0.26 0.37 0.215 0.025 0.07 0 0.48 0.009957506 ‐0.441666667 7837 PXDN ‐0.04 ‐0.31 ‐0.68 0.395 ‐0.1 0.035 0.1 0 0.16 0.026979166 ‐0.441666667 283643 C14orf80 ‐0.285 0.155 ‐0.485 0.46 0.275 0.43 0.21 ‐0.04 0.085 0.035324528 ‐0.441666667 81616 ACSBG2 ‐0.2 ‐0.21 ‐0.85464 0.0134375 ‐0.25 0.16 0 0.14 0.052407 0.033324343 ‐0.440855104 25921 ZDHHC5 ‐0.17 ‐0.29 ‐0.6 0.18 ‐0.03 0 0.05 0.14 0.18 0.003229503 ‐0.44 84301 DDI2 ‐0.25352 ‐0.43352 ‐0.23352 ‐0.2235185 0.3764815 0.36648148 ‐0.11852 0.256481 0.136481 0.02641299 ‐0.439166667 6760 SS18 ‐0.055 ‐0.275 ‐0.54 0.27 0.16 ‐0.13 0.34 0.2 0.03 0.015717603 ‐0.435 3866 KRT15 ‐0.17333 ‐0.17667 ‐0.44 ‐0.1133333 0.35 0.26666667 0.066667 0.033333 0.423333 0.015631084 ‐0.434444445 22863 KIAA0831 ‐0.39667 0 ‐0.28667 ‐0.1466667 0.3183333 0.12333333 ‐0.01333 0.503333 0.45 0.041453625 ‐0.433611111 26986 PABPC1 ‐0.118 ‐0.17167 ‐0.69 0.1983333 0.17 0.278 ‐0.28333 0 0.275 0.043399987 ‐0.432888889 123096 SLC25A29 ‐0.005 ‐0.305 ‐0.715 0.135 ‐0.05 0 0.395 ‐0.09 0.15 0.040171963 ‐0.431666667 37 ACADVL ‐0.23 ‐0.09 ‐0.765 0.165 0.315 0.16 0 ‐0.225 0.005 0.042746561 ‐0.431666667 79751 SLC25A22 ‐0.505 ‐0.41 ‐0.215 0.105 ‐0.045 0.075 0 0.05 0.125 0.000400091 ‐0.428333333 2959 GTF2B ‐0.68 ‐0.49 ‐0.01 0.09 ‐0.07 ‐0.04 ‐0.06 0.18 0.11 0.021204071 ‐0.428333333 682 BSG ‐0.6175 ‐0.075 ‐0.435 ‐0.3525 0.1625 0.2425 0.0425 0.0825 0.1375 0.034175851 ‐0.428333333 10094 ARPC3 ‐0.125 ‐0.22 ‐0.675 0.23 0.035 0.12 0.025 0.165 ‐0.05 0.01198105 ‐0.4275 10608 MXD4 ‐0.485 ‐0.19 ‐0.2 0.355 ‐0.09 0.21 0.05 0.09 0.195 0.00644611 ‐0.426666667 26872 STEAP1 ‐0.034 ‐0.048 ‐0.24 0.246 0.3 0 0.542 0.47 0.354 0.010027472 ‐0.426 23563 CHST5 ‐0.17333 ‐0.22333 ‐0.35333 0 0.2033333 0.59666667 0.006667 0.076667 0.16 0.017749523 ‐0.423888889 9554 SEC22B ‐0.27333 ‐0.61 ‐0.29667 0.1133333 ‐0.1333333 ‐0.04666667 0.206667 ‐0.10667 0.146667 0.006708902 ‐0.423333333 57048 PLSCR3 ‐0.25 ‐0.23 ‐0.53 ‐0.07 0.16 0.07 0.44 ‐0.06 ‐0.02 0.014954567 ‐0.423333333 93109 TMEM44 ‐0.23 0 ‐0.435 ‐0.02 0.59 ‐0.115 0.185 0.395 0.175 0.047027972 ‐0.423333333 5150 PDE7A ‐0.02 ‐0.10667 ‐0.77 0 0.1 0.17666667 0.215 0.163333 0.09 0.034653758 ‐0.423055556 26272 FBXO4 0.056667 ‐0.7 ‐0.43667 0.18 ‐0.0733333 0 0.215 ‐0.08667 0.143333 0.037727265 ‐0.423055556 8509 NDST2 ‐0.78 ‐0.12 ‐0.18 0.1 ‐0.18 ‐0.05 0.07 0.08 0.35 0.045560553 ‐0.421666667 389 RHOC 0.086667 ‐0.17 ‐0.68 0.3133333 0.0133333 0.19666667 0.286667 0.21 ‐0.02 0.041824498 ‐0.421111111 11060 WWP2 ‐0.2465 ‐0.3625 ‐0.3425 ‐5.00E‐04 ‐0.0125 0.105 0.3125 0.1525 0.065 0.000830121 ‐0.420833333 3241 HPCAL1 ‐0.48 ‐0.005 ‐0.25 0.315 0.09 0.22 ‐0.155 0.29 0.295 0.020363126 ‐0.420833333 92335 STRADA ‐0.27 ‐0.335 ‐0.25 0 0.37 ‐0.345 0.17 0.5 0.12 0.049812174 ‐0.420833333 79672 FN3KRP ‐0.13 ‐0.25 ‐0.49 0.41 0.06 0.34 0 ‐0.09 0.06 0.018481529 ‐0.42 113655 MFSD3 ‐0.225 ‐0.47 ‐0.535 ‐0.31 0.295 0.19 0.235 ‐0.05 ‐0.32 0.049568549 ‐0.416666667 84630 TTBK1 ‐0.35 ‐0.71 0 0.05 0.42 ‐0.04 ‐0.08 0.11 ‐0.08 0.049741727 ‐0.416666667 51449 PCYOX1 ‐0.13333 ‐0.19 ‐0.24333 0.13 0.49 0.03333333 0.51 0.2 0 0.017657492 ‐0.416111111 3655 ITGA6 ‐0.38 0.05 ‐0.605 ‐0.025 0.16 ‐0.11666667 0.056667 0.273333 0.275 0.034027701 ‐0.415555556 771 CA12 ‐0.01 ‐0.771 ‐0.36 0 0.03 0.047 0.197 ‐0.025 ‐0.03833 0.029800785 ‐0.415444445 801 CALM1 ‐0.03933 ‐0.21733 ‐0.555 0.075 0 0.23066667 0.39 0.150667 0.022667 0.01645023 ‐0.415388889 8073 PTP4A2 ‐0.41333 ‐0.115 ‐0.63 ‐0.2216667 0.1933333 0.17 ‐0.245 0.111667 0.166667 0.033033836 ‐0.415277778 55207 ARL8B ‐0.28667 ‐0.14 ‐0.54 0.1466667 0.1433333 ‐0.1 0 0.323333 0.043333 0.009044463 ‐0.415 55665 URGCP ‐0.02 ‐0.21 ‐0.17 0.4 0 0.45 0.59 ‐0.02 0.27 0.03013394 ‐0.415 22921 MSRB2 ‐0.16 ‐0.27 ‐0.52 ‐0.2 0.23 0.44 ‐0.11 0.08 0.15 0.031876722 ‐0.415 79733 E2F8 0 ‐0.135 ‐0.14 0.785 0.145 0.265 0.07 0.405 0.255 0.03242269 ‐0.4125 221545 C6orf136 ‐0.19 ‐0.04 ‐0.3 0.58 0.05 0.12 0.54 0.05 0.07 0.036199767 ‐0.411666667 9275 BCL7B ‐0.39 0 ‐0.31 0.63 ‐0.07 0.085 0.045 0.29 0.09 0.044515748 ‐0.411666667 55832 CAND1 ‐0.30833 ‐0.7325 0 0.255 ‐0.135 0.0125 0.2575 ‐0.0025 ‐0.00167 0.044300245 ‐0.41125 835 CASP2 ‐0.68667 ‐0.02667 ‐0.2775 0.04 0 0.285 0.01 0.17 ‐0.04 0.026962489 ‐0.407777778 51108 METTL9 ‐0.39 ‐0.525 0 0.41 0.0166667 0.03666667 ‐0.10667 0.1 0.16 0.027434168 ‐0.407777778 10634 GAS2L1 ‐0.17417 ‐0.17417 ‐0.41417 0.1775 0.0025 0.365 0 0.1325 0.2425 0.004584596 ‐0.4075 127534 GJB4 ‐0.69 ‐0.09 ‐0.13 0.25 0.305 ‐0.07 0 0.055 0.085 0.032863076 ‐0.4075 6992 PPP1R11 0.016667 ‐0.32 ‐0.68 0.0266667 ‐0.0966667 0.06333333 0.353333 0.123333 0 0.039100944 ‐0.406111111 23516 SLC39A14 ‐0.64 ‐0.015 ‐0.245 ‐0.04 0.355 0.14833333 ‐0.025 ‐0.015 0.205 0.032942039 ‐0.404722222 3769 KCNJ13 ‐0.035 ‐0.43 ‐0.47 0 0.295 0.1 0.215 ‐0.095 0.04 0.014297587 ‐0.404166667 5688 PSMA7 ‐0.33 ‐0.05 ‐0.695 0.15 0.03 0.065 0.105 0.08 ‐0.16 0.022445547 ‐0.403333333 23654 PLXNB2 0 ‐0.05 ‐0.585 0.395 0.1375 0.3275 0.12 0.0375 0.1275 0.029669832 ‐0.4025 3783 KCNN4 ‐0.105 ‐0.18 ‐0.605 0.285 ‐0.1 0.04 0.31 0.095 0 0.024532193 ‐0.401666667 94081 SFXN1 0 ‐0.23667 ‐0.71 0.1666667 ‐0.16 0.06666667 0.336667 0.046667 0.056667 0.048102433 ‐0.401111112 727 C5 ‐0.10611 ‐0.04 ‐0.15 ‐0.04 0.23 0.4 0.76 0.15 0.31 0.043461056 ‐0.40037037 23196 FAM120A ‐0.35067 ‐0.35667 ‐0.32867 0.2866667 0.165 0.05666667 ‐0.165 ‐0.01833 0 0.003737127 ‐0.399500001 51248 PDZD11 ‐0.36 0.01 ‐0.55 ‐0.14 0.18 0.41 0.07 ‐0.02 0.09 0.037288841 ‐0.398333333 2843 GPR20 ‐0.20667 ‐0.53667 ‐0.59667 ‐0.12 ‐0.0166667 0.06666667 ‐0.32 0.066667 0.026667 0.012735931 ‐0.397222223 7475 WNT6 ‐0.37167 ‐0.365 ‐0.34167 ‐0.09 ‐0.065 0.055 0 0.451667 ‐0.125 0.016841151 ‐0.397222223 3628 INPP1 ‐0.12 ‐0.265 ‐0.54 0.185 0.195 0.005 ‐0.07 0.14 0.075 0.006081601 ‐0.396666667 83877 TM2D2 ‐0.41 0 ‐0.4975 ‐0.1825 0.1975 0.1225 ‐0.0675 0.13 0.3425 0.035087671 ‐0.392916667 6692 SPINT1 ‐0.28 0.005 ‐0.56 0 0.35 ‐0.12 ‐0.01 0.235 0.23 0.037006601 ‐0.3925 27123 DKK2 ‐0.29 ‐0.15531 ‐0.7 0 0.015 0.11475 ‐0.195 0 0.125 0.017978855 ‐0.391729167 84458 LCOR ‐0.585 ‐0.455 ‐0.31 ‐0.17 0.175 ‐0.175 ‐0.07 ‐0.115 0 0.004380907 ‐0.390833333 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 85414 SLC45A3 ‐0.05 0 ‐0.32 ‐0.03 0.3 0.445 ‐0.055 0.55 0.39 0.049616271 ‐0.39 1508 CTSB 0.013333 ‐0.3 ‐0.56667 0.41 0.2866667 0 0.003333 0.053333 ‐0.12333 0.047948391 ‐0.389444445 79086 C19orf42 ‐0.13333 ‐0.27667 ‐0.59333 0.1033333 0.0133333 0.07666667 0.243333 ‐0.11 0 0.011142062 ‐0.388888889 9695 EDEM1 ‐0.55333 ‐0.21 ‐0.36667 ‐0.3133333 0.11 3.47E‐18 0.116667 0.156667 0 0.015151965 ‐0.388333334 55144 LRRC8D ‐0.29 ‐0.345 ‐0.1 0.255 0.225 ‐0.23 0.085 0.29 0.23 0.018232348 ‐0.3875 1409 CRYAA ‐0.60037 ‐0.31037 ‐0.15537 0.0296296 0.0346296 ‐0.01037037 0.017011 0 0.11963 0.003509731 ‐0.38712522 51604 PIGT 0.0225 ‐0.23333 ‐0.6 0.25 0.2033333 ‐0.0625 0.306667 ‐0.00333 0 0.037342746 ‐0.385972222 6253 RTN2 ‐0.01 ‐0.31 ‐0.305 0.075 0.43 ‐0.015 0.445 0.13 0 0.028517307 ‐0.385833333 1317 SLC31A1 ‐0.512 ‐0.098 ‐0.292 0.048 0.212 0.148 0 0.18 ‐0.08 0.007521318 ‐0.385333333 8771 TNFRSF6B ‐0.365 ‐0.335 ‐0.42 0.03 0.07 ‐0.035 0.045 ‐0.065 0.025 1.0621E‐05 ‐0.385 195814 SDR16C5 ‐0.245 0 ‐0.54 0.15 0.195 ‐0.09 ‐0.07 0.06 0.48 0.04995548 ‐0.3825 11198 SUPT16H ‐0.24 ‐0.12667 ‐0.33 0.3133333 0.2633333 0.20333333 0.106667 0.086667 ‐0.07333 0.00430806 ‐0.382222222 25896 INTS7 ‐0.07 ‐0.145 ‐0.475 0.2875 0 0.1875 0.255 0.0675 0.115 0.008343867 ‐0.382083333 79081 C11orf48 ‐0.404 0 ‐0.712 ‐0.066 ‐0.022 0.122 ‐0.082 0.022 0.07 0.032864823 ‐0.379333333 9158 FIBP ‐0.345 ‐0.105 ‐0.515 0.08 ‐0.02 0.34 ‐0.1 0.005 0.035 0.01567909 ‐0.378333333 57154 SMURF1 ‐0.44 ‐0.15 ‐0.4 ‐0.0866667 0.2283333 0.08333333 0.073333 0.038333 ‐0.04667 0.003798261 ‐0.378333333 9667 SAFB2 ‐0.43 ‐0.065 ‐0.135 0.29 0.2 0.275 ‐0.085 0.32 0 0.019376456 ‐0.376666667 6900 CNTN2 0 ‐0.055 ‐0.275 0.36 ‐0.15 0.325 0.213333 0.503333 0.34 0.03557003 ‐0.375277778 5600 MAPK11 ‐0.445 ‐0.26 ‐0.535 ‐0.305 0.08 0 ‐0.14 0.03 0.105 0.010101154 ‐0.375 79001 VKORC1 ‐0.265 ‐0.055 ‐0.4 0.165 0.35 0.315 0.165 0 ‐0.185 0.028758211 ‐0.375 285398 LOC285398 ‐0.57 ‐0.14 ‐0.1 ‐0.08 0.18 ‐0.05 0.37 0 0.21 0.035589801 ‐0.375 25774 GSTTP1 ‐0.0125 ‐0.466 ‐0.09 0.08 ‐0.06 0.12 0.43 0.18 0.35 0.033651525 ‐0.372833333 9527 GOSR1 ‐0.49533 ‐0.066 ‐0.29367 0 ‐0.004 0.17966667 ‐0.07867 0.173 0.256 0.013383778 ‐0.372666667 6733 SRPK2 ‐0.35333 ‐0.40667 ‐0.09 0 ‐0.0533333 0.08 0.376667 0.153333 ‐0.03333 0.015040239 ‐0.370555556 8788 DLK1 ‐0.3425 ‐0.3025 ‐0.665 ‐0.05 ‐0.0775 ‐0.0875 0.139167 0 ‐0.3225 0.015904704 ‐0.370277778 4595 MUTYH ‐0.41 ‐0.355 ‐0.055 0.295 0.13 0 0.115 0.045 ‐0.015 0.00759123 ‐0.368333333 5780 PTPN9 ‐0.45 ‐0.485 0.025 0.22 0.13 0.16 0.165 ‐0.285 0 0.049137067 ‐0.368333333 388341 C17orf76 0 0.01 ‐0.48 0.13 0.3 ‐0.05 0.24 0.41 0.24 0.03537215 ‐0.368333333 11231 SEC63 ‐0.16 ‐0.24333 ‐0.25 0.29 0.2933333 ‐0.09 ‐0.07333 0.476667 0 0.036046174 ‐0.367222222 4297 MLL ‐0.255 ‐0.07 ‐0.24 0.3825 0.199 0.12666667 ‐0.077 0.378333 0.056667 0.01556661 ‐0.366027778 149473 CCDC24 ‐0.23 ‐0.175 ‐0.39 0.11 0.425 0.105 ‐0.18 ‐0.025 0.17 0.024458084 ‐0.365833333 51324 SPG21 ‐0.46 ‐0.23 ‐0.26 0.1 ‐0.03 0.22 0.05 ‐0.07 0.02 0.00220248 ‐0.365 23141 ANKLE2 ‐0.07 ‐0.285 ‐0.155 0.395 0.365 ‐0.02 0.29 ‐0.065 0.205 0.02161157 ‐0.365 8295 TRRAP ‐0.41 ‐0.25 ‐0.21 0.3 ‐0.04 0.29 0.01 ‐0.22 0.11 0.023669201 ‐0.365 64802 NMNAT1 ‐0.115 ‐0.255 ‐0.52 0.33 0.015 ‐0.025 0.105 0 ‐0.02 0.014541553 ‐0.364166667 3852 KRT5 ‐0.27 ‐0.5125 ‐0.0575 0.005 ‐0.0275 0.08833333 0.115 0.131667 0.1925 0.007896112 ‐0.364166667 85438 C4orf35 ‐0.09 ‐0.565 ‐0.23 0.1 0.225 0.135 ‐0.14 ‐0.145 0.22 0.03329703 ‐0.360833333 23527 ACAP2 ‐0.355 ‐0.02 ‐0.42 ‐0.01 0.19 0 0.095 0.16 0.135 0.006901104 ‐0.36 8553 BHLHE40 ‐0.31 ‐0.32 ‐0.12 0.12 0.1 0.01 0.22 0.2 0 0.001329881 ‐0.358333333 125981 ACER1 ‐0.22714 ‐0.67714 ‐0.01714 0.0728571 0.2328571 0.11285714 ‐0.01631 ‐0.09714 0 0.042768912 ‐0.357996032 23096 IQSEC2 0 ‐0.055 ‐0.285 0.135 0.43 0.12 ‐0.025 0.285 0.52 0.033688343 ‐0.3575 9057 SLC7A6 ‐0.348 ‐0.258 ‐0.088 0.246 0 ‐0.146 0.028 0.308 0.32 0.024553114 ‐0.357333333 26608 TBL2 ‐0.16 ‐0.18 ‐0.25 0.33 ‐0.06 0 0.42 0.2 0.07 0.017189122 ‐0.356666667 112869 CCDC101 ‐0.38 0 ‐0.2 0.33 ‐0.13 0.2 0.34 ‐0.06 0.3 0.041584363 ‐0.356666667 283897 C16orf54 ‐0.06 ‐0.1 ‐0.42933 0.07 0.09 0.19 0.13 0.25 0.23 0.005046499 ‐0.356444444 8603 FAM193A ‐0.09 ‐0.03 ‐0.46667 0.3766667 0.28 0 0.026667 0.086667 0.193333 0.025774735 ‐0.356111111 56603 CYP26B1 ‐0.28 ‐0.17 ‐0.38 0.02 0.02 ‐0.05 0 0.37 0.115 0.008910636 ‐0.355833333 51524 TMEM138 0 ‐0.07 ‐0.51 0 ‐0.02 0.48 0.16 0.19 0.16 0.049615975 ‐0.355 5689 PSMB1 ‐0.185 ‐0.1 ‐0.26 0.31 ‐0.035 0 0.41 0.19 0.165 0.012989454 ‐0.355 2322 FLT3 0.05 ‐0.41 ‐0.64 0.075 ‐0.09 0.07666667 0.02 ‐0.02333 0.065 0.037963082 ‐0.353888889 11054 OGFR ‐0.02 0 ‐0.42 0.26 0.24 0.26 0.26 0.12 0.1 0.009684845 ‐0.353333333 79815 NIPAL2 ‐0.245 ‐0.155 ‐0.21 0.2 0.425 ‐0.14 0.035 0.07 0.31 0.023846596 ‐0.353333333 29880 ALG5 ‐0.39 ‐0.04 ‐0.47 0 0.27 0.02 ‐0.05 0.07 0 0.015106236 ‐0.351666667 8706 B3GALNT1 ‐0.015 ‐0.22 ‐0.255 0.39 0 ‐0.065 0.345 0.25 0.21 0.022269114 ‐0.351666667 114884 OSBPL10 ‐0.18 0 ‐0.42333 ‐0.11 0.1866667 0.04666667 0.216667 0.3 0.263333 0.023871809 ‐0.351666667 3329 HSPD1 ‐0.648 ‐0.394 ‐0.11 ‐0.082 0 0.0425 ‐0.23 0.1225 ‐0.0575 0.026280242 ‐0.349916667 83451 ABHD11 ‐0.33333 ‐0.17667 ‐0.02667 0.1033333 0.1666667 0.30333333 0.44 0 0.006667 0.021848229 ‐0.348888889 4101 MAGEA2 ‐0.49 ‐0.08 ‐0.26 0.11 0.13 ‐0.06 0.06 0.07 0.12 0.005567541 ‐0.348333333 2348 FOLR1 ‐0.16 ‐0.315 ‐0.17 0.27 ‐0.01 0.145 0.29 0.175 ‐0.075 0.007745441 ‐0.3475 10325 RRAGB ‐0.215 0 ‐0.255 0.295 0.145 0.405 0.365 0.11 ‐0.175 0.040064126 ‐0.3475 64787 EPS8L2 0.07 ‐0.3 ‐0.6525 0.145 0.11 0.04 0 ‐0.0175 0.0425 0.043876074 ‐0.3475 11142 PKIG ‐0.14 ‐0.17 ‐0.24 0.36 0 0.09 0.54 ‐0.09 0.08 0.046579821 ‐0.346666667 51228 GLTP ‐0.06 ‐0.27 ‐0.41 0.41 0.07 0 ‐0.01 0 0.12 0.021423398 ‐0.345 84811 BUD13 ‐0.39 0.05 ‐0.09 0.195 0.1 0.4 ‐0.015 0.29 0.24 0.025143422 ‐0.345 7425 VGF ‐0.24 ‐0.175 ‐0.49 0.035 0.075 0.07 ‐0.07 0.025 0.115 0.002265158 ‐0.343333333 10395 DLC1 ‐0.10167 ‐0.57167 ‐0.34167 0.2783333 0.1483333 0 ‐0.21667 ‐0.06667 ‐0.12667 0.045847829 ‐0.341111111 4049 LTA ‐0.19271 ‐0.12 ‐0.42 0.06 0 0.2 ‐0.08333 0.33 0.072333 0.014866723 ‐0.340736111 5147 PDE6D ‐0.05 ‐0.27 ‐0.37 0.24 0.2 0.17 0 0.05 ‐0.01 0.006911152 ‐0.338333333 6940 ZNF354A ‐0.20667 ‐0.29 ‐0.11667 0.3966667 0.1633333 0 0.026667 0.233333 ‐0.02 0.013378299 ‐0.337777778 874 CBR3 ‐0.265 0.085 ‐0.165 0.1883333 0.17 0.225 0.328333 0.295 0.128333 0.004497385 ‐0.3375 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 10458 BAIAP2 ‐0.13467 ‐0.25467 ‐0.34867 0.015 ‐0.1526667 ‐0.06066667 0.201333 0.157333 0.387333 0.029843968 ‐0.337277778 3597 IL13RA1 ‐0.07333 ‐0.07 ‐0.62 0 0.2266667 0.00333333 0.026667 0.14 0.1 0.037006761 ‐0.337222222 9887 SMG7 ‐0.385 ‐0.37 ‐0.095 0.01 0.01 0.015 0.18 0.17 ‐0.065 0.005600577 ‐0.336666667 11270 NRM ‐0.01 ‐0.02 ‐0.395 ‐0.04 0.405 0.41 0.145 0.105 0.14 0.041840225 ‐0.335833333 9049 AIP ‐0.3 ‐0.015 ‐0.475 ‐0.005 0.245 0.29 0.095 ‐3.47E‐18 ‐0.2 0.047303949 ‐0.334166667 90799 CCDC45 ‐0.255 ‐0.31 ‐0.225 0.28 0.255 ‐0.03 ‐0.175 ‐0.05 0.13 0.019679279 ‐0.331666667 8659 ALDH4A1 ‐0.31667 ‐0.22667 ‐0.275 0.1016667 0.0266667 0.31666667 0.06 ‐0.155 0 0.009490002 ‐0.331111112 85301 COL27A1 ‐0.16 ‐0.24333 ‐0.40333 ‐0.0183333 0.2766667 ‐0.06333333 ‐0.23333 0.196667 0.206667 0.03541117 ‐0.329722222 55379 LRRC59 ‐0.35 ‐0.14667 ‐0.31333 0 ‐0.1266667 0.13 0.21 ‐1.39E‐17 0.14 0.005863679 ‐0.328888889 54187 NANS ‐0.075 ‐0.295 ‐0.38 0.145 ‐0.125 0.205 0.22 0.135 ‐0.115 0.021274652 ‐0.3275 4683 NBN ‐0.365 ‐0.2 ‐0.45 0.03 ‐0.3 ‐0.06 0 0.04 0.225 0.022929946 ‐0.3275 7031 TFF1 ‐0.55 ‐0.125 ‐0.23 0 0.275 0.045 ‐0.2475 0.095 ‐0.025 0.042891801 ‐0.325416667 9716 AQR ‐0.375 ‐0.105 ‐0.255 0.035 0.18 0 0 0.24 0.025 0.004856427 ‐0.325 4065 LY75 0.04 ‐0.27 ‐0.265 0.11 0.015 0.08 0.325 0.43 0 0.035409841 ‐0.325 167153 PAPD4 0.140833 ‐0.05167 ‐0.05333 0.2208333 0.4566667 0.30583333 0.485833 0.25 0.295833 0.004273891 ‐0.323888889 165631 PARP15 ‐0.14 ‐0.08 ‐0.18 0.16 0.34 0 0.5 0.16 ‐0.02 0.032107847 ‐0.323333333 3459 IFNGR1 ‐0.53 ‐0.25 ‐0.2 ‐0.03 ‐0.03 0.07 ‐0.16 0.12 0 0.008376486 ‐0.321666667 10066 SCAMP2 ‐0.07667 ‐0.20333 ‐0.57667 0.2233333 ‐0.1066667 ‐0.04666667 0.086667 0 0.05 0.032113609 ‐0.32 5436 POLR2G ‐0.08 ‐0.17 ‐0.42 0.28 ‐0.08 0.34 0.04 ‐0.01 0.01 0.034206715 ‐0.32 8650 NUMB ‐0.21 ‐0.11 ‐0.39 0 ‐0.01 0.02 0.06 0.24 0.18 0.006070922 ‐0.318333333 55917 CTTNBP2NL ‐0.245 ‐0.20167 ‐0.25833 0.2883333 0.065 0 ‐0.04833 0.075 0.11 0.002780219 ‐0.316666667 80122 YSK4 ‐0.14 ‐0.11526 ‐0.49984 0.17 0 0.04240476 0.025833 0.128272 0.02 0.010363352 ‐0.316118846 55285 RBM41 ‐0.045 ‐0.135 ‐0.445 ‐0.055 0.065 0.035 0.06 0.365 0.175 0.031608313 ‐0.315833333 51103 NDUFAF1 ‐0.12 ‐0.36 ‐0.26 0.24 ‐0.14 ‐0.09 0.25 0 0.14 0.024861303 ‐0.313333333 220906 LOC220906 ‐0.04 ‐0.23 ‐0.4 0.26 0.22 0.04 0.22 ‐0.06 ‐0.14 0.03613245 ‐0.313333333 159091 FAM122C ‐0.01594 ‐0.06 ‐0.24 0.16 0.22 ‐0.15 0.37 0.42 0.22 0.045191558 ‐0.311981481 29763 PACSIN3 ‐0.245 0.095 ‐0.25 0.105 0.23 0.425 0.195 0.11 0 0.030094089 ‐0.310833333 84939 MUM1 ‐0.475 ‐0.185 ‐0.28 ‐0.195 0.005 0 ‐0.09 0.1 0.16 0.013571082 ‐0.31 2923 PDIA3 ‐0.005 ‐0.34 ‐0.325 0.095 0.115 0.01 0.305 0 ‐0.01 0.018316506 ‐0.309166667 79701 C17orf101 ‐0.02 ‐0.125 ‐0.39 0.265 0.305 0.145 0.145 ‐0.055 ‐0.02 0.029076958 ‐0.309166667 58526 MID1IP1 ‐0.09 ‐0.39 ‐0.11 ‐0.1766667 ‐0.0833333 0.22333333 0.2 0.253333 0.256667 0.049962472 ‐0.308888889 10159 ATP6AP2 ‐0.38 0.04 ‐0.41 ‐0.09 0.28 ‐0.01 0.11 0 0.04 0.041126834 ‐0.305 51569 UFM1 ‐0.245 ‐0.0325 ‐0.445 ‐0.12 0.1208333 0.23 ‐0.0425 0.1475 0.0475 0.027338792 ‐0.304722222 10096 ACTR3 0 ‐0.18333 ‐0.44667 0.0933333 ‐0.0433333 ‐0.00666667 0.336667 0.086667 0.09 0.035039599 ‐0.302777778 55504 TNFRSF19 ‐0.34 ‐0.195 ‐0.35 0.14 ‐0.09 ‐0.24 0 0.145 0.085 0.016133918 ‐0.301666667 11076 TPPP ‐0.08 ‐0.415 ‐0.36 0.18 ‐0.06 0.08 ‐0.22 ‐0.09 0.21 0.04174291 ‐0.301666667 6575 SLC20A2 ‐0.19 ‐0.525 ‐0.23 ‐0.22 ‐0.08 0.035 ‐0.15 0.235 0.085 0.043225704 ‐0.299166667 8190 MIA ‐0.33 0.11 ‐0.27 ‐0.07 0.13 0.22 0.27 0.01 0.25 0.045113266 ‐0.298333333 27289 RND1 ‐0.16819 ‐0.41875 ‐0.09875 0.02925 ‐0.006369 0.34125 0.08125 0.12125 ‐0.14875 0.036949162 ‐0.29821164 9509 ADAMTS2 ‐0.29 ‐0.14667 ‐0.04 0.42 0 0.11666667 0.2925 ‐0.0325 0.0275 0.040631768 ‐0.29625 64083 GOLPH3 ‐0.2 ‐0.345 ‐0.19 ‐0.145 ‐0.085 0.145 0.36 0 0.03 0.034713754 ‐0.295833333 10732 TCFL5 ‐0.02 0 ‐0.32 0.16 ‐0.03 0.32 ‐0.02 0.29 0.37 0.049463601 ‐0.295 9923 ZBTB40 ‐0.205 ‐0.345 ‐0.14 0.015 ‐0.085 ‐0.105 0.385 0.175 0 0.041276573 ‐0.294166667 221150 SKA3 ‐0.205 ‐0.17 ‐0.005 0.34 0.065 0.395 0.11 0 0.09 0.026021828 ‐0.293333333 1945 EFNA4 ‐0.31 0.07 ‐0.57 ‐0.01 0.09 0.03 ‐0.02 0.01 0.04 0.049876196 ‐0.293333333 148867 SLC30A7 ‐0.44 ‐0.276 ‐0.206 ‐0.254 0.116 0 ‐0.24 0.128 0.162 0.046492617 ‐0.292666667 147179 WIPF2 ‐0.17 0 ‐0.395 0.005 0.25125 ‐0.0125 0.07625 0.18875 0.11125 0.019701146 ‐0.291666667 5558 PRIM2 0.036667 ‐0.45333 ‐0.14 0.19 0.1066667 0.16666667 ‐0.02333 0.013333 0.176667 0.031407122 ‐0.290555556 26507 CNNM1 ‐0.03 ‐0.015 ‐0.43 0.28 0.13125 0.03 0 0.255 0.09125 0.036846347 ‐0.289583333 3996 LLGL1 ‐0.12746 ‐0.0645 ‐0.34936 0.0355 0.3755 0.0655 ‐0.0245 0.2055 ‐0.0145 0.033156881 ‐0.287608025 2720 GLB1 ‐0.34 ‐0.3 ‐0.165 0 0.135 ‐0.145 ‐0.04 0.13 0.035 0.005423278 ‐0.2875 2356 FPGS ‐0.26 ‐0.045 ‐0.22 0.07 0.025 0.25 0.355 0 ‐0.03 0.026356148 ‐0.286666667 167826 OLIG3 ‐0.09 ‐0.19 ‐0.27 ‐0.09 ‐0.06 0.37 0.22 0.18 0 0.039985498 ‐0.286666667 4005 LMO2 ‐0.41 ‐0.2 ‐0.04 0.01 0 0.18 0.135 0.15 ‐0.065 0.017312789 ‐0.285 84282 RNF135 ‐0.025 ‐0.27 ‐0.28 0.07 0.04 0.035 0.15 0.25 0 0.008432766 ‐0.2825 29951 PDZRN4 ‐0.02 ‐0.445 ‐0.105 0.11125 0 0.125 0.115 0.165 0.025 0.019687787 ‐0.280208333 7084 TK2 ‐0.0685 ‐0.0905 ‐0.4975 ‐0.085 0.11 0.07 0.1425 0 0.1295 0.032650332 ‐0.28 1761 DMRT1 ‐0.39 ‐0.04 ‐0.15 0 0.18 0.02555556 0.33 0 ‐0.02 0.035679112 ‐0.279259259 6996 TDG ‐0.584 ‐0.462 ‐0.07 0 ‐0.1 0.01 ‐0.164 ‐0.194 ‐0.124 0.044638674 ‐0.276666667 9061 PAPSS1 ‐0.09 ‐0.09 ‐0.17 0.18 0.26 0.21 0.14 ‐0.07 0.24 0.007322037 ‐0.276666667 84334 C14orf153 ‐0.24 0 ‐0.18 0.12 0.24 0.19 0.32 0.05 ‐0.11 0.031348778 ‐0.275 1616 DAXX ‐0.24 ‐0.03 ‐0.08 0.41 0.03 0.26 0.27 ‐0.02 0 0.047347458 ‐0.275 57497 LRFN2 ‐0.1 ‐0.24833 ‐0.255 0 ‐0.06 0.11 0.27 0.025 0.095 0.008733844 ‐0.274444444 64396 GMCL1L ‐0.15 ‐0.17458 0 0.21 0.04 ‐0.02 0.25 0.1 0.38 0.026034504 ‐0.268194444 9156 EXO1 ‐0.45 ‐0.3 0 0.04 0.08 0.07 0.1 ‐0.22 0.02 0.049762202 ‐0.265 128602 C20orf85 ‐0.285 0.015 ‐0.24 0.14 0.185 0.275 0.045 ‐0.095 0.015 0.033283683 ‐0.264166667 2675 GFRA2 ‐0.165 ‐0.29 ‐0.07 ‐0.12 0 0.08 0.185 0.21 0.18 0.019793381 ‐0.264166667 2693 GHSR ‐0.3 ‐0.28 ‐0.14 0.05 0.03 0.01 ‐0.1 0.04 0.11 0.001599594 ‐0.263333333 55327 LIN7C ‐0.31333 ‐0.15 ‐0.5 ‐0.0666667 ‐0.07 0.09333333 ‐0.17667 0 ‐0.14 0.020969051 ‐0.261111111 84445 LZTS2 ‐0.2 ‐0.075 ‐0.26 0.07 0.09 0.045 0.1 0.165 0.025 0.000775779 ‐0.260833333 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 51289 RXFP3 ‐0.26 ‐0.23 ‐0.19 ‐0.105 0.05 0.315 0.01 0 ‐0.065 0.022685335 ‐0.260833333 1284 COL4A2 ‐0.37 ‐0.23 ‐0.06 0.06 0.1366667 0.04333333 0 ‐6.94E‐18 0.003333 0.005901188 ‐0.260555556 7518 XRCC4 ‐0.04 ‐0.09 ‐0.29 0.11 0.15 0.02 0.14 0 0.3 0.015348763 ‐0.26 64766 S100PBP ‐0.305 ‐0.14 0.08 0.12 0.185 0.155 0 0.125 0.235 0.020861748 ‐0.258333333 25806 VAX2 ‐0.16 ‐0.23 0 0.21 ‐0.02 ‐0.06 0.3 0.22 0.12 0.031445482 ‐0.258333333 144453 BEST3 ‐0.3 ‐0.19 ‐0.21 0.18 0.06 0.12 0 ‐0.04 ‐0.18 0.014305054 ‐0.256666667 90806 ANGEL2 ‐0.49333 ‐0.33 ‐0.11 ‐0.0633333 0.0233333 ‐0.23666667 ‐0.1 0.013333 0.023333 0.031458733 ‐0.254444444 284485 C1orf230 ‐0.4 ‐0.11 ‐0.11 0 0.12 0.16 ‐0.16 ‐0.01 0.17 0.037808308 ‐0.253333333 79137 FAM134A ‐0.17 ‐0.11 ‐0.31 ‐0.04 0.18 ‐0.11 0.195 0.12 ‐0.01 0.020720086 ‐0.2525 10401 PIAS3 ‐0.18 ‐0.205 ‐0.22 0.01 0.13 0.09 0 0.11 ‐0.05 0.000701145 ‐0.25 51773 RSF1 ‐0.0255 ‐0.196 ‐0.236 0.25 0.122 0.086 ‐0.012 0.226 ‐0.102 0.030440077 ‐0.2475 79729 C1orf113 ‐0.095 ‐0.275 ‐0.105 ‐0.07 0.39 0 0.065 0.095 0.055 0.045869475 ‐0.2475 3988 LIPA ‐0.31 ‐0.21333 ‐0.3 ‐0.1233333 ‐0.0033333 ‐0.13333333 0 0.06 0.033333 0.002235657 ‐0.246666667 79723 SUV39H2 ‐0.025 ‐0.07 ‐0.25 0.36 0.03 0.26 0.1 0.05 ‐0.025 0.04434762 ‐0.244166667 441850 LOC441850 ‐0.17 0 ‐0.07 0.32 ‐0.01 0.21 0.25 0.06 0.154259 0.018584612 ‐0.24404321 91133 L3MBTL4 ‐0.085 ‐0.01458 0 0.37 0.17 0.09 0.33 0.33 ‐0.0363 0.043200121 ‐0.242145062 4891 SLC11A2 ‐0.4125 ‐0.245 ‐0.215 ‐0.215 0.0275 ‐0.1075 ‐0.1875 0.18 0 0.043336293 ‐0.240416667 25979 DHRS7B ‐0.298 ‐0.08 ‐0.206 ‐0.062 0.156 0.016 0.142 0.068 ‐0.068 0.01279639 ‐0.236666667 5446 PON3 ‐0.06 ‐0.18 ‐0.25 0.05 0.29 0.11 ‐0.03 0.02 0 0.019493061 ‐0.236666667 283489 ZNF828 ‐0.41 ‐0.15 ‐0.06 0.03 0.06 0.05 ‐0.19 0.14 0.09 0.044610303 ‐0.236666667 4947 OAZ2 ‐0.165 0.075 ‐0.26 0 0.165 0.295 0.09 0.01 0.15 0.0390903 ‐0.235 1742 DLG4 ‐0.055 ‐0.11 ‐0.12 0.11 0 0.04 0.215 0.155 0.3 0.011173184 ‐0.231666667 84849 MGC16142 ‐0.32 0 ‐0.28611 0.060625 0.14 ‐0.00616667 ‐0.01 ‐0.07 0.060417 0.022825526 ‐0.23118287 22894 DIS3 0.1 ‐0.24333 ‐0.35 0.09 0.0366667 0.08 0 0.09 0.093333 0.040970917 ‐0.229444444 1908 EDN3 ‐0.16 ‐0.004 ‐0.22 0.1 0.0675 0.1 0.26 0 0.04 0.013711492 ‐0.222583333 4076 CAPRIN1 ‐0.126 ‐0.286 ‐0.18 ‐0.034 0 0.108 ‐0.098 ‐0.018 0.186 0.015147027 ‐0.221333333 7737 RNF113A ‐0.17 ‐0.15 0 0.12 0.14 0.3 0.11 0.03 ‐0.02 0.021255737 ‐0.22 341019 DCDC1 ‐0.01 ‐0.22 ‐0.19 0.23 ‐0.13 0.07 0.1 0.2 0.005833 0.044547759 ‐0.219305556 80243 PREX2 0.05 ‐0.08 ‐0.19 0.19 0 0.18 0.17 0.2 0.132083 0.011008369 ‐0.218680556 6895 TARBP2 ‐0.18 ‐0.25 ‐0.02 0.19 ‐0.07 0 0.17 0.12 ‐0.02 0.029550728 ‐0.215 10166 SLC25A15 ‐0.13 ‐0.04 ‐0.2 0.23 ‐0.0525714 0.25 0.09 0 0.028958 0.031959893 ‐0.214397817 51285 RASL12 ‐0.13 ‐0.04 ‐0.225 0.015 ‐0.115 0.195 0.04 0.145 0.21 0.036171227 ‐0.213333333 403340 MGC70870 ‐0.13 ‐0.3 ‐0.02 0.14 ‐0.01 0.27 ‐0.05 0.04 ‐0.01 0.048919461 ‐0.213333333 25994 HIGD1A ‐0.185 ‐0.22 ‐0.155 ‐0.07 ‐0.155 0.135 0.06 0.075 0.105 0.017609997 ‐0.211666667 147429 C18orf16 ‐0.13 ‐0.14 0 0.14 0.09 0 0.27 0.24 ‐0.01 0.027650885 ‐0.211666667 55146 ZDHHC4 ‐0.23 ‐0.1 ‐0.37 ‐0.12 0.07 0.05 0 0.06 ‐0.19 0.037142522 ‐0.211666667 64924 SLC30A5 ‐0.145 ‐0.18833 ‐0.0275 0.065 0.0975 ‐0.04833333 0.281667 0.1325 0.015 0.025493189 ‐0.210833333 90993 CREB3L1 ‐0.225 0.06 ‐0.325 0.01 0.045 ‐0.03 0.105 0.145 0 0.044297626 ‐0.209166667 282617 IL28B ‐0.08611 ‐0.28 ‐0.10071 0 0.17 0.03333333 0.15 ‐0.07 0.035625 0.018248487 ‐0.208768188 9364 RAB28 0.008333 ‐0.1 0 0.3233333 ‐0.0266667 0.11333333 0.176667 0.248333 0.216667 0.030268752 ‐0.205833333 8795 TNFRSF10B ‐0.26 ‐0.295 0.015 ‐0.1 0.095 0.045 0.135 0 ‐0.03 0.04175541 ‐0.204166667 8444 DYRK3 ‐0.07 ‐0.295 ‐0.15 0 ‐0.025 ‐0.05 0.17 ‐0.015 0.1 0.019677276 ‐0.201666667 3889 KRT83 ‐0.01313 ‐0.07625 ‐0.17625 0.13375 0.00375 0.23375 0.27375 0.025 0 0.038532148 ‐0.200208333 7201 TRHR ‐0.2 ‐0.29 0 0.0566667 0.0133333 ‐0.06833333 ‐0.02 0.166667 0.056667 0.031925162 ‐0.1975 658 BMPR1B ‐0.065 ‐0.345 ‐0.02 0.12 0.0742857 0.01738095 0.049792 0 0.03 0.031258347 ‐0.191909722 91662 NLRP12 ‐0.12 ‐0.06 ‐0.12 0.13 0 0.15 0.164759 0 0.09 0.004414062 ‐0.189126543 23397 NCAPH 0.048333 ‐0.00167 ‐0.115 0.3383333 0.1983333 0.16166667 0.11 0.125 0.06 0.024430833 ‐0.188333334 2566 GABRG2 ‐0.16 ‐0.25 ‐0.04 ‐0.03 ‐0.07 0.11 0.06 0.16 0 0.024153046 ‐0.188333333 2999 GZMH ‐0.105 ‐0.225 ‐0.185 ‐0.205 0.175 0.045 0.025 ‐0.005 0.065 0.046632187 ‐0.188333333 8763 CD164 ‐0.185 ‐0.09 ‐0.23 0.155 0.105 0.045 ‐0.17 0 ‐0.03 0.038965875 ‐0.185833333 6327 SCN2B ‐0.24333 ‐0.05333 ‐0.15667 0.0533333 ‐0.0233333 0.04333333 ‐0.01583 0.14 0 0.008813734 ‐0.184027778 123775 C16orf46 ‐0.19 ‐0.05 ‐0.01 0 0.12 0.17 0.03 0.23 0.05 0.024284581 ‐0.183333333 1830 DSG3 ‐0.12 ‐0.02 ‐0.18 0 ‐0.06 0.2 0.13 0.197857 ‐0.01875 0.046804185 ‐0.181517857 85481 PSKH2 ‐0.10438 ‐0.28438 ‐0.11438 0.055625 0.0167361 0 ‐0.06438 ‐0.00438 0.075625 0.007218181 ‐0.180914352 79685 SAP30L ‐0.245 ‐0.145 ‐0.08 0.1 0.02 0.02 0.095 ‐0.07 ‐0.03 0.009812447 ‐0.179166667 284391 ZNF844 ‐0.07 ‐0.06306 ‐0.21 ‐0.0478333 0.05 0 0.17 0.210741 0 0.037135235 ‐0.178169753 2218 FKTN ‐0.165 ‐0.02 ‐0.135 ‐0.005 0.15 0.075 0.11 0.02 0.015 0.008795115 ‐0.1675 219681 ARMC3 ‐0.12833 ‐0.045 ‐0.09833 0.1616667 ‐0.0083333 0.18583333 0.141667 ‐0.07483 0 0.049747544 ‐0.158222222 25834 MGAT4C ‐0.0603 ‐0.0503 ‐0.0703 0.1097 0.0501583 0.1297 0.0097 0.1047 0.1797 0.003245871 ‐0.157576389 154386 C6orf195 ‐0.28 0.010271 ‐0.2 ‐0.01 0.0444259 ‐0.01271667 ‐0.05 0.010389 0.00213 0.03635797 ‐0.153947685 9775 EIF4A3 0 ‐0.15 ‐0.10.130.08‐0.06 0.17 0.07 0.03 0.028949073 ‐0.153333333 51751 HIGD1B ‐0.05 ‐0.15 0 ‐0.03 0.21 0.04 0.12 0.14 0.02 0.041886814 ‐0.15 6138 RPL15 ‐0.05 ‐0.165 ‐0.19 0.08 0.04 ‐0.065 0.0075 0.02 ‐0.0175 0.009163567 ‐0.145833333 2814 GP5 ‐0.115 ‐0.065 ‐0.22 0.0533333 ‐0.065 0.035 0.06 0.03 ‐0.07 0.018806726 ‐0.140555556 8471 IRS4 ‐0.1137 ‐0.02537 ‐0.11296 0 0.0750463 0.1062963 0.156296 ‐0.0537 0.026296 0.028428565 ‐0.135717592 150353 DNAJB7 ‐0.15626 ‐0.01015 ‐0.18626 ‐0.0128725 0.0067747 ‐0.01258857 0.133736 ‐0.00095 ‐0.00796 0.029061253 ‐0.135249675 84616 KRTAP4‐4 ‐0.10979 0 ‐0.25051 0.0002083 0.0065046 0.03020833 ‐0.01979 0.030208 0.041399 0.029369275 ‐0.134888668 5915 RARB ‐0.06 ‐0.14 0.03 0.11 0.05 ‐0.0226 0.101917 0.11 0.02 0.037261465 ‐0.118219445 6101 RP1 ‐0.0025 ‐0.08125 ‐0.0125 0.1775 0.0675 0.0275 0 0.1275 0.066944 0.035093461 ‐0.109907407 140870 WFDC6 ‐0.06147 ‐0.08147 ‐0.03147 0.0020419 ‐0.0114672 ‐0.01146724 0.119283 0.078533 0.018533 0.031033679 ‐0.090709848 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 219287 FAM123A ‐0.07531 ‐0.0092 ‐0.12531 0.0846887 0.0077272 ‐0.01163609 ‐0.00098 0 ‐0.00701 0.032420673 ‐0.082073511 4317 MMP8 0 0.08 0.044775 ‐0.0166088 0.0030385 ‐0.01632479 ‐0.00567 ‐0.00469 ‐0.0117 0.015610929 0.050249294 140625 ACTRT2 ‐0.01562 0.084689 0.049464 ‐0.0119201 ‐0.0353113 ‐0.01163609 ‐0.00098 0 ‐0.00701 0.044441136 0.05065232 252995 FNDC5 0.084689 ‐0.0092 0.064689 ‐0.0119201 0.0077272 ‐0.0153113 ‐0.00098 0 ‐0.00701 0.032989576 0.05130715 60482 SLC5A7 0.035 0.105 0 0 0 ‐0.07 ‐0.10548 ‐0.025 ‐0.16 0.043313013 0.106746032 2204 FCAR 0.04 0.1 0.04 ‐0.07 0.01 ‐0.055 ‐0.095 ‐0.08 ‐8.67E‐18 0.007395024 0.108333333 60401 EDA2R 0.1 0.06 0.12 0.08 ‐0.14 0.02 ‐0.05 0 ‐0.08063 0.039194767 0.121770833 389208 TMPRSS11F 0.169903 0.081554 0.067514 ‐0.097375 ‐0.007375 0.052625 ‐0.02738 0 ‐0.01738 0.011138552 0.122469246 259234 DSCR10 0.056961 0.176961 0.041736 ‐0.1030385 0 ‐0.01936332 ‐0.0087 ‐0.04304 ‐0.02304 0.010202234 0.124750312 285 ANGPT2 0.115 0.08 0.056667 0.01 ‐0.14 ‐0.035 ‐0.13333 ‐0.005 0.053333 0.035902112 0.125555556 54210 TREM1 0.19 0.069167 0.03 0.0189583 ‐0.0752381 ‐0.04738095 ‐0.03 0 ‐0.05 0.012020439 0.126999008 29901 SAC3D1 0.065 0.045 0.085 0 ‐0.11 0.05 ‐0.08 ‐0.125 ‐0.115 0.021556689 0.128333333 81615 TMEM163 0.05625 0.12625 0.0225 ‐0.11375 0 ‐0.035625 ‐0.04375 ‐0.05375 ‐0.17208 0.013648442 0.138159722 150365 MEI1 0.095 0.105 0.055 0.075 0 ‐0.13 ‐0.15 ‐0.02 ‐0.095 0.033998489 0.138333333 170482 CLEC4C 0.1025 0.1725 0.0425 ‐0.0075 0 ‐0.1075 ‐0.0375 0.038958 ‐0.0875 0.011907457 0.139340278 10121 ACTR1A 0.023333 0.166667 0.166667 ‐0.0666667 ‐0.0033333 0.07333333 ‐0.00333 0.03 ‐0.15667 0.045143989 0.14 338785 KRT79 0.125521 0.12 0.022407 ‐0.0927778 ‐0.0616667 ‐0.12 ‐0.09 ‐0.01 0.07 0.020894498 0.140050154 7166 TPH1 0.06213 ‐0.01995 0.10213 ‐0.1478704 ‐0.0731829 0.00212963 ‐0.04237 ‐0.09787 ‐0.22787 0.0305426 0.145940972 64324 NSD1 0.115 0.24 0.135 0.045 ‐0.055 ‐0.07 0.145 ‐0.005 0.025 0.026127761 0.149166667 22938 SNW1 0.1 0.073333 0.153333 ‐0.0566667 0.01 ‐0.13666667 ‐0.09 ‐0.01667 0.03 0.007360161 0.152222222 140685 ZBTB46 0.19 0.03 0.2 ‐0.09 ‐0.04 0 0.02 ‐0.09 0.12 0.036866411 0.153333333 953 ENTPD1 0.05 0.21 0 ‐0.2 ‐0.05 ‐0.04 ‐0.10407 0 ‐0.0125 0.038460383 0.154429012 219854 TMEM218 0.2 0.03 0.22 ‐0.12 ‐0.01 0.1 0.04 0.03 ‐0.07 0.040621988 0.155 64577 ALDH8A1 0.283333 0.213333 0 0.0433333 0.0633333 ‐0.03666667 ‐0.05667 ‐0.04167 0.073333 0.047555381 0.158055556 7553 ZNF7 0.07 0.03 0.16 0.02 0.07 ‐0.21 ‐0.12 ‐0.1 ‐0.09 0.046119927 0.158333333 10284 SAP18 0.196667 0.09 0.213333 ‐0.0533333 0.0533333 0.14666667 ‐0.10667 0 ‐0.00333 0.028030112 0.160555556 3868 KRT16 0.215 0.115 0.04 ‐0.01 ‐0.135 0.035 ‐1.39E‐17 ‐0.115 0 0.019435518 0.160833333 126364 LRRC25 0.09 0.21 0.006481 0 ‐0.14 0.06 ‐0.03 ‐0.15 ‐0.11 0.036916922 0.16382716 4152 MBD1 0.2 ‐0.07 0.16 ‐0.1166667 ‐0.1066667 ‐0.01333333 0.036667 ‐0.12667 ‐0.07667 0.045554574 0.163888889 51206 GP6 0.06 0.18 0.22 0.12 ‐0.0508333 0.02 0 ‐0.05531 ‐0.11 0.022529858 0.166024306 27199 OXGR1 0.13 0.07 0.203148 0.07 0.04 ‐0.00083333 ‐0.04433 ‐0.07 ‐0.19 0.028984007 0.166910494 8000 PSCA 0.086667 0.22 0.115 ‐0.14 ‐0.0066667 0.01333333 0.103333 ‐0.01667 ‐0.14 0.028383741 0.171666667 158263 FLJ31713 0.085313 0.035313 0.195313 ‐0.2079583 ‐0.0827431 0 ‐0.10469 0.055313 ‐0.06469 0.027618501 0.172773148 79612 NAA16 0.218 0.1255 0.07 ‐0.082 0 ‐0.1195 ‐0.147 0.008 0.128 0.036022756 0.17325 6819 SULT1C2 0.13 0.18 0.187143 0.09 ‐0.11 0 ‐0.03 0.13 ‐0.14 0.030280511 0.175714286 5037 PEBP1 0.2075 0.0225 0.3125 ‐0.0675 0.055 0 0.1475 ‐0.0575 ‐0.0725 0.049880624 0.18 808 CALM3 0.26 0.055 0.1 ‐0.145 ‐0.03 0.1 ‐0.14 0.065 ‐0.115 0.046985682 0.1825 57533 TBC1D14 0.05 0.05 0.316667 ‐0.0433333 ‐0.0733333 ‐0.11 0.013333 0.026667 ‐0.09333 0.028111488 0.185555556 51503 CWC15 0.1 0.18 0.12 ‐0.04 ‐0.06 0 ‐0.24 0.13 ‐0.12 0.040959298 0.188333333 689 BTF3 0.01 0.14 0.235 ‐0.055 ‐0.17 ‐0.035 0.03 0 ‐0.14 0.020088833 0.19 151278 CCDC140 0.13 0.07 0.38 0.08 0.1 0 ‐0.0413 ‐0.1 ‐0.04 0.040865668 0.193549383 7225 TRPC6 0.268167 0 0.0645 ‐0.01 ‐0.16 ‐0.12 ‐0.02 0.03 ‐0.22 0.043510027 0.194222222 2977 GUCY1A2 0.1335 ‐0.01 0.285 0.09 ‐0.0766667 ‐0.1 ‐0.155 ‐0.145 0.025 0.045315212 0.196444445 3189 HNRNPH3 0.32 0.075 0.14 0.035 ‐0.035 ‐0.01 ‐0.065 ‐0.035 0 0.007028895 0.196666667 124857 WFIKKN2 0.202333 0.164 0.109 ‐0.051 ‐0.141 ‐0.1385 0.079 0 0.009 0.008675095 0.198861111 5110 PCMT1 0.135 0.045 0.215 ‐0.0875 0.06 0 ‐0.12 ‐0.105 ‐0.16 0.011303239 0.200416667 89858 SIGLEC12 0.085 0.26 0.17 ‐0.15 ‐0.01 0.07 0 ‐0.2 0.115 0.041481844 0.200833333 7472 WNT2 0.075 0.345 0.02 0 0.02 ‐0.05 ‐0.01 ‐0.07 ‐0.22 0.047311542 0.201666667 144699 FBXL14 0.095 0.065 0.29 ‐0.075 0.015 ‐0.23 0.095 ‐0.065 ‐0.08 0.035826177 0.206666667 283232 TMEM80 0.26 0.03 0.05 ‐0.06 ‐0.07 ‐0.32 0 ‐0.08 ‐0.04 0.040987934 0.208333333 493869 GPX8 0.165 0.29 0.055 ‐0.18 0.035 0.015 ‐0.13 0 0.025 0.021049531 0.209166667 5108 PCM1 0.3175 0.096667 0.275 0.14 0.03 ‐0.085 ‐0.12667 0 0.1625 0.038576182 0.209583334 65056 GPBP1 0.185 0.13 0.043333 0 ‐0.255 0.00333333 ‐0.02333 ‐0.115 ‐0.15333 0.016781191 0.21 9749 PHACTR2 0.14 0.05 0.23 0.01 0.03 ‐0.19 ‐0.21 ‐0.13 0.07 0.034305525 0.21 29909 GPR171 0.05 0.02 0.07 ‐0.2666667 0 ‐0.18 ‐0.38 ‐0.14 ‐0.03556 0.041237583 0.213703704 10165 SLC25A13 0.046667 0.126667 ‐0.12333 ‐0.19 ‐0.2333333 ‐0.24 ‐0.31 0.033333 ‐0.24667 0.041790194 0.214444445 92691 TMEM169 0.239375 0.299375 0.059375 ‐0.080625 0 ‐0.082625 0.159375 0.071458 ‐0.18063 0.040196428 0.218215278 387129 NPSR1 0.31 0.01 0.041667 ‐0.07 ‐0.115 ‐0.00142857 ‐0.12 ‐0.297 0.016875 0.049039542 0.218314484 4063 LY9 0.416964 0.166667 0.07474 0.0166667 0.1666667 ‐0.12333333 0 ‐0.07333 0.02 0.044521706 0.218345734 22872 SEC31A 0.298 0.148 0.1705 0.0555 0.0055 ‐0.08 ‐0.026 ‐0.088 0.048 0.002525056 0.219666667 7251 TSG101 0.275 0.235 0.065 ‐0.115 ‐0.02 ‐0.095 0.005 0.055 0 0.006304708 0.22 9643 MORF4L2 0.323333 ‐0.03 0.28 ‐0.0933333 ‐0.0066667 0.00666667 0.01 ‐0.09 ‐0.01667 0.024684119 0.222777778 29919 C18orf8 0.43 0.28 0.05 0.025 0.17 ‐0.005 ‐0.09 0 0.075 0.040244963 0.224166667 59341 TRPV4 0.19 0.036875 0.226875 0.076875 ‐0.094375 ‐0.24026786 0.066875 ‐0.05313 ‐0.20313 0.037028968 0.22577381 5683 PSMA2 0.01 0.01 0.37 0.005 ‐0.165 ‐0.125 ‐0.04 ‐0.15 ‐0.105 0.036646017 0.226666667 6137 RPL13 0 0.052 0.134 ‐0.248 0.042 ‐0.022 ‐0.376 ‐0.226 ‐0.168 0.048018548 0.228333333 10178 ODZ1 0.09 0 0.15 ‐0.19 ‐0.3 ‐0.25777778 ‐0.09 ‐0.01 ‐0.06633 0.016672767 0.232351852 27349 MCAT 0.23 0.065 0.175 ‐0.01 ‐0.075 ‐0.005 0.02 ‐0.215 ‐0.175 0.009852539 0.233333333 139081 MAGEC3 0.01 0.11 0.11 ‐0.17 ‐0.0564815 ‐0.21 ‐0.2 0.00037 ‐0.31 0.012770079 0.234351852 84240 ZCCHC9 0 0.19 0.06 ‐0.1 ‐0.15 0.05 ‐0.16 ‐0.13 ‐0.42 0.047792149 0.235 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 27233 SULT1C4 0.426961 ‐0.01693 0.246961 0.0169615 0 ‐0.01936332 ‐0.07304 ‐0.00773 ‐0.01473 0.029534231 0.235315533 7371 UCK2 0.16 0.045 0.27 0.095 ‐0.275 ‐0.11 0.015 ‐0.045 ‐0.145 0.032045466 0.235833333 54542 RC3H2 0.02 0.074 0.086 ‐0.112 ‐0.388 ‐0.0035 ‐0.302 ‐0.26 ‐0.006 0.044284885 0.238583333 5718 PSMD12 0.203333 0.123333 0.216667 ‐0.1433333 ‐0.1733333 ‐0.06666667 ‐0.04333 0 0.073333 0.004237065 0.24 10767 HBS1L 0.02 0.046667 0.303333 0 0.0766667 ‐0.12833333 ‐0.21 ‐0.20333 ‐0.24 0.041910862 0.240833333 27247 NFU1 0.18 0.23 0.01 ‐0.22 0.02 ‐0.03 ‐0.23 ‐0.05 ‐0.1 0.014997009 0.241666667 23524 SRRM2 0.07 0.265 0.353333 ‐0.1575 0 0.0925 ‐0.0575 ‐0.075 0.115 0.02201002 0.243194444 5716 PSMD10 0.34 0.04 0.2 0.17 ‐0.05 0 ‐0.23 ‐0.17 ‐0.02 0.047321267 0.243333333 196951 C15orf33 ‐0.09622 0.046 0.21063 ‐0.354 ‐0.164 ‐0.3025 0.016 ‐0.144 ‐0.194 0.040274446 0.243885803 7776 ZNF236 0.098 0.032 0.2515 ‐0.344 0 ‐0.2035 ‐0.19 0.044 ‐0.014 0.044008381 0.245083333 57019 CIAPIN1 0.235 0.12 0.185 0.115 ‐0.155 ‐0.145 ‐0.025 ‐0.025 ‐0.16 0.008896906 0.245833333 54939 COMMD4 0.306667 0.006667 0.263333 0 ‐3.47E‐18 0.14333333 ‐0.26667 ‐0.14333 ‐0.05667 0.049377892 0.246111111 55863 TMEM126B 0 0.315 0.22 ‐0.01 0.11 ‐0.245 ‐0.23 0.015 ‐0.055 0.049157882 0.2475 10412 NSA2 0.105 0.195 0.07 0.04 ‐0.095 ‐0.245 ‐0.015 ‐0.3 ‐0.145 0.018536248 0.25 54826 GIN1 0.1 0.21 0.4 0 ‐0.07 0.17 0.02 ‐0.11 ‐0.1 0.02102322 0.251666667 2696 GIPR 0 0.165 0.085 ‐0.34 ‐0.335 ‐0.21 ‐0.025 0.005 ‐0.11 0.032684527 0.2525 257103 NCRNA00205 0.168333 0.031667 0.348333 ‐0.1883333 ‐0.1083333 ‐0.195 ‐0.015 0 0.081667 0.025424636 0.253611111 51016 FAM158A 0.42 0.07 0.3 ‐0.11 0.055 0.075 0.02 0 0.015 0.013513199 0.254166667 55703 POLR3B 0.016667 0.033333 0.25 ‐0.2066667 ‐0.43 ‐0.09333333 ‐0.12 ‐0.07667 0 0.042210037 0.254444445 10424 PGRMC2 0.435 0 0.213333 0.02 0.1266667 ‐0.13 ‐0.1 ‐0.14 ‐0.02 0.04126361 0.256666667 55325 UFSP2 0.26 0.05 0.12 ‐0.29 ‐0.16 ‐0.16 ‐0.03 0.03 ‐0.07 0.014232289 0.256666667 387893 SETD8 0.346667 0.141333 0.165 0 ‐0.0486667 0.07533333 ‐0.01333 ‐0.05667 ‐0.19167 0.006780584 0.256833334 80148 PQLC1 0.19 ‐0.07 0.37 ‐0.04 ‐0.23 0 ‐0.14 ‐0.05 ‐0.10333 0.033110462 0.257222222 55846 ITFG2 0.213333 0.166667 0.256667 ‐0.0966667 0 ‐0.01333333 0.083333 ‐0.02667 ‐0.22 0.004972865 0.257777778 25875 LETMD1 0.02 0.176667 0.396667 ‐0.0566667 0 ‐0.23333333 2.78E‐17 ‐0.06333 ‐0.01667 0.022429416 0.259444445 6154 RPL26 0.1075 0.0975 0.125 0.075 ‐0.1625 ‐0.31 ‐0.0025 ‐0.1725 ‐0.3275 0.030969536 0.26 377677 CA13 0.006667 0.155 0.23 0.08 ‐0.095 ‐0.135 ‐0.42 ‐0.06 ‐0.15 0.045232357 0.260555556 79667 FLJ13197 ‐0.01778 0.1 0.13 ‐0.3325 ‐0.22 ‐0.10666667 ‐0.11 0.03 ‐0.4 0.034761761 0.260601852 6607 SMN2 0.265 0.1575 0.15 0.065 ‐0.2275 ‐0.0225 0 0.0475 ‐0.29 0.025661484 0.262083333 5515 PPP2CA 0.2675 0 0.0775 ‐0.1425 ‐0.0966667 0.0075 0.025 ‐0.37 ‐0.3075 0.048508836 0.262361111 389831 LOC389831 0.405 0.085 0.35 0.09 ‐0.075 ‐0.005 ‐0.145 0.115 0.12 0.024587672 0.263333333 6945 MLX 0.363333 0.28 0.236667 ‐0.04 ‐0.0366667 0 0.086667 0.186667 ‐0.03 0.002972137 0.265555556 50628 GEMIN4 0.07 0.315 0.3925 0.135 ‐0.1325 ‐0.085 0.104167 ‐0.06 0 0.021582556 0.265555556 5713 PSMD7 0.276667 0.24 0.166667 ‐0.05 0 ‐0.00666667 ‐0.19 0.07 ‐0.05 0.00208327 0.265555556 51527 C14orf129 0.305 0.435 0.245 0 0.065 0.215 ‐0.055 ‐0.09 0.235 0.020802596 0.266666667 51377 UCHL5 0.2 0 0.335 0.11 ‐0.1675 ‐0.145 ‐0.0125 ‐0.1125 ‐0.205 0.025771275 0.267083333 51138 COPS4 0.37 0.075 0.3 ‐3.47E‐18 ‐0.005 0.005 ‐0.025 0 ‐0.09 0.003550553 0.2675 5929 RBBP5 0.175 0.06 0.145 ‐0.115 ‐0.06 ‐0.12 ‐0.26 ‐0.29 0 0.00711861 0.2675 4817 NIT1 0.385 0.055 0.305 ‐0.08 0 0.14 0.025 ‐0.09 ‐0.115 0.017294261 0.268333333 51263 MRPL30 0.15 0.13 0.22 0 ‐0.0925 ‐0.2075 ‐0.2425 0.085 ‐0.155 0.010298989 0.26875 56951 C5orf15 0.32 0.165 0.105 ‐0.005 ‐0.055 ‐0.325 0 ‐0.045 ‐0.005 0.016704754 0.269166667 10213 PSMD14 0.27 0.18 0.1 ‐0.23 ‐0.15 ‐0.02 ‐0.09 0 ‐0.03 0.003398627 0.27 1038 CDR1 0.18 ‐0.07 0.32 0 ‐0.245 ‐0.10296296 ‐0.02 ‐0.155 ‐0.24 0.027776355 0.270493827 64210 MMS19 0.103333 0.086667 0.296667 ‐0.09 ‐0.0766667 ‐0.14333333 ‐0.13 ‐0.21 0 0.003065796 0.270555556 23742 C15orf2 0.21 0.044444 0.177 ‐0.4035 0.06 ‐0.14 ‐0.25 ‐0.03 0 0.042375734 0.271064815 118487 CHCHD1 0.22 0.15 0.15 0.01 ‐0.285 ‐0.24 0.095 ‐0.06 ‐0.11 0.017809043 0.271666667 8293 SERF1A 0.01 0.18 0.2925 ‐0.325 ‐0.17 ‐0.03 ‐0.0925 ‐0.0475 0 0.019276497 0.271666667 54882 ANKHD1 0.306 0.05 0.168 ‐0.038 ‐0.104 ‐0.372 0.0435 ‐0.164 0.038 0.034922496 0.274083333 11335 CBX3 0.215 0.115 0.445 0.115 0.085 ‐0.04 ‐0.2 ‐0.08 0.02 0.02244365 0.275 150280 HORMAD2 0.405666 ‐0.00822 0.365666 ‐0.010943 0.0256657 ‐0.01065905 0 ‐0.12433 ‐0.00603 0.019928887 0.275419587 25843 MOBKL3 0.343333 0.27 0.12 0 ‐0.3033333 ‐0.07333333 0.14 ‐0.05667 0.1 0.031821857 0.276666667 54881 TEX10 0.1 0.09 0.56 ‐0.06 0 ‐0.10.010.02‐0.03 0.033914799 0.276666667 9101 USP8 0.11 0.13 0.45 ‐0.1766667 0.015 0 ‐0.06 ‐0.025 ‐0.03667 0.012413297 0.277222222 6232 RPS27 0.23 0.04 0.125 ‐0.07 ‐0.08 ‐0.215 ‐0.39 ‐0.125 ‐2.08E‐17 0.01780555 0.278333333 441272 SPDYE3 0.49 0.02 0.15 0 ‐0.24 0.10333333 ‐0.00083 ‐0.11333 ‐0.1 0.047433813 0.278472222 201965 RWDD4A 0.325 0.24 0.39 0.28 0.18 0.065 ‐0.14 ‐0.135 ‐0.02 0.03271991 0.28 6917 TCEA1 0.263 0.193 0.338 ‐0.1395 0 0.13133333 0.034667 ‐0.086 ‐0.037 0.002959557 0.28075 8678 BECN1 0.312 0.134 0.216 0 ‐0.174 ‐0.15 0.118 ‐0.058 ‐0.098 0.006109141 0.281 54680 ZNHIT6 0.08 0 0.28 ‐0.06 ‐0.145 ‐0.05 ‐0.25 ‐0.255 ‐0.21 0.008216567 0.281666667 55695 NSUN5 0.18 0.06 0.35 0.04 ‐0.04 ‐0.13 ‐0.04 ‐0.09 ‐0.25 0.010187938 0.281666667 143384 C10orf46 0.07 0 0.31 ‐0.005 ‐0.385 ‐0.28 0.045 ‐0.12 ‐0.185 0.04452563 0.281666667 51318 MRPL35 0.065 0.33 0.375 ‐0.26 0 ‐0.025 ‐0.145 0.2 0.075 0.044469567 0.2825 259295 TAS2R20 0.3918 0.0094 0.21475 0.02 ‐0.07 ‐0.19 ‐0.0785 ‐0.3 0.12 0.03998183 0.2884 54928 IMPAD1 0.168571 0.465714 0.245714 ‐0.0571429 ‐0.1471429 ‐0.09142857 0.131429 0 0.19 0.021300108 0.289047619 55669 MFN1 0.105 ‐0.01 0.415 ‐0.2325 0 ‐0.1525 0.06 ‐0.2875 ‐0.1075 0.039798419 0.29 26278 SACS 0.23 0.018 0.352 ‐0.13 ‐0.148 ‐0.232 0.066 0.05 ‐0.152 0.019399972 0.291 2806 GOT2 0.193333 0.043333 0.41 0.0633333 ‐0.0866667 0 ‐0.16333 ‐0.21 ‐0.06667 0.01556446 0.292777778 84289 ING5 0.002 ‐0.126 0.164 0.02 ‐0.4375 ‐0.29 ‐0.166 ‐0.48 ‐0.325 0.048828307 0.293083333 2963 GTF2F2 0.02 0.14 0.37 ‐0.145 ‐0.135 ‐0.16 ‐0.09 ‐0.045 ‐0.125 0.004662168 0.293333333 10212 DDX39 0.12 0.19 0.18 0.1 ‐0.23 ‐0.22 0 ‐0.17 ‐0.26 0.012759198 0.293333333 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 51154 MRTO4 0.255 0.065 0.135 0.045 ‐0.34 ‐0.03 ‐0.115 ‐0.13 ‐0.285 0.017453881 0.294166667 9681 DEPDC5 0.465 0.09 0.03 ‐0.155 ‐0.195 ‐0.18 0.04 0 ‐0.105 0.028160772 0.294166667 54906 C10orf18 0.245 0.065 0.345 ‐0.03 ‐0.115 ‐0.165 ‐0.27 ‐0.09 0.215 0.033613308 0.294166667 59343 SENP2 0.353333 0.233333 0.383333 ‐0.1466667 ‐0.0733333 0.01666667 0.426667 ‐0.03 ‐0.03667 0.04951855 0.297222222 10425 ARIH2 0.383333 0.016667 0.32 ‐0.0866667 ‐0.19 0 ‐0.14 0.07 ‐0.01 0.015405974 0.299444445 10730 YME1L1 0.225 0.095 0.6 0.155 0.03 ‐0.075 ‐0.05 0 ‐0.03 0.029464375 0.301666667 8408 ULK1 0.1125 0 0.1375 0.0525 ‐0.2025 ‐0.2975 ‐0.055 ‐0.3725 ‐0.44833 0.036360293 0.303888889 151963 C3orf59 0.1048 0.1448 0.4648 ‐0.2852 ‐0.1552 0 ‐0.0752 0.075541 0.0448 0.028348045 0.304009877 9276 COPB2 0.115 ‐0.02 0.485 ‐0.29 ‐0.17 ‐0.16 ‐0.005 ‐0.04 0 0.039550101 0.304166667 1582 CYP8B1 0.395 0.38 0.065 0 ‐0.25 ‐0.04 ‐0.02 0.27 ‐0.105 0.043588991 0.304166667 10923 SUB1 0.12 0.113333 0.106667 ‐0.2033333 ‐0.21 ‐0.27333333 ‐0.44667 ‐0.01667 0 0.018474046 0.305 1401 CRP 0.08 0.49 0.116667 ‐0.285 ‐0.0666667 0 ‐0.07667 0.006667 ‐0.035 0.024896515 0.305 3687 ITGAX 0 0.118333 0.053333 ‐0.0716667 ‐0.2216667 ‐0.45166667 ‐0.46667 ‐0.07667 ‐0.20167 0.024277662 0.305555556 126282 TNFAIP8L1 ‐0.01 0.223333 0.376667 ‐0.0966667 ‐0.2 ‐0.08666667 0 ‐0.30667 0.03 0.022522267 0.306666667 65109 UPF3B 0 0.326667 0.516667 ‐0.1366667 0.0433333 0.13 ‐0.21667 0.03 ‐0.01 0.042955673 0.307777778 11040 PIM2 0.093333 0.153333 0.226667 ‐0.11 ‐0.3266667 ‐0.29 0.213333 ‐0.20667 ‐0.18333 0.035688179 0.308333333 3799 KIF5B 0.35 0.12 0.25 0.16 ‐0.1 ‐0.14 0.2 ‐0.24 ‐0.29 0.049068483 0.308333333 50999 TMED5 0.105 0.245 0.31 ‐0.12 0.05 ‐0.265 ‐0.09 0 ‐0.11 0.004868839 0.309166667 353355 ZNF233 0.2289 ‐0.0011 0.2589 ‐0.0911 ‐0.2911 ‐0.2600375 0 ‐0.1411 ‐0.1111 0.007831934 0.31130625 51128 SAR1B 0.1 0.08 0.17 ‐0.29 ‐0.32 ‐0.15 ‐0.27 ‐0.01 ‐0.13 0.003783586 0.311666667 7186 TRAF2 0.16 0.11 0.29 ‐0.28 ‐0.295 0.045 ‐0.13 0 ‐0.09 0.011068661 0.311666667 84250 ANKRD32 0.37 0.23 0.39 0.08 ‐0.07 0.08 ‐0.3 0.2 0.12 0.027087839 0.311666667 51426 POLK 0.38 ‐0.012 0.306 ‐0.0305 0.0245 ‐0.004 ‐0.272 ‐0.334 0.0895 0.0469089 0.312416667 79048 SECISBP2 0.353333 0.193333 0.086667 ‐0.47 0 ‐0.11666667 ‐0.00333 ‐0.01 ‐0.01 0.037467038 0.312777778 8813 DPM1 ‐0.01 0.14 0.4 0.07 ‐0.09 ‐0.27 ‐0.25 ‐0.18 ‐0.1 0.023384063 0.313333333 126231 ZNF573 0.25 0.21 0.31 0 ‐0.15 ‐0.14 ‐0.3 0.27 ‐0.02 0.031485192 0.313333333 85287 KRTAP4‐7 0.064 0.248 0.13 ‐0.27 0.026 ‐0.126 ‐0.532 0.012 ‐0.106 0.046511189 0.313333333 80318 GKAP1 0.19 0.25 0.46 0.03 0.05 0.01 ‐0.14 ‐0.04 0 0.002273108 0.315 23063 WAPAL 0.07 0.205 0.595 0 ‐0.095 ‐0.045 ‐0.065 0.085 ‐0.035 0.023652467 0.315833333 10484 SEC23A 0.625 0.115 0.12 ‐0.1 0.085 ‐0.175 0.11 ‐0.12 0.02 0.046552994 0.316666667 3359 HTR3A 0.12 0.03 0.15 ‐0.3003333 ‐0.19 ‐0.07 ‐0.52 ‐0.22 0 0.025593488 0.316722222 10910 SUGT1 0.003333 0.15 0.35 ‐0.34 ‐0.1433333 ‐0.07333333 ‐0.29 0 ‐0.05 0.019443702 0.317222222 56675 NRIP3 0.266667 0 0.193333 ‐0.4783333 ‐0.2533333 0.1 ‐0.14833 ‐0.00333 ‐0.20667 0.046113254 0.318333333 23367 LARP1 0.085 0.16 0.38 ‐0.37 ‐0.055 ‐0.345 0.08 ‐0.005 0.035 0.045676071 0.318333333 6141 RPL18 0.135 0.13 0.435 ‐0.165 ‐0.15 0 ‐0.07 0.075 ‐0.225 0.011072572 0.3225 80139 ZNF703 0.075 0.065 0.405 ‐0.275 ‐0.13 ‐0.145 ‐0.24 ‐0.065 0 0.01168074 0.324166667 23212 RRS1 ‐0.005 0.135 0.445 ‐0.13 ‐0.425 ‐0.07 ‐0.135 0 ‐0.035 0.036965559 0.324166667 3188 HNRNPH2 0.41 ‐0.04 0.355 ‐0.205 ‐0.005 ‐0.27 ‐0.02 0 0 0.028118199 0.325 6563 SLC14A1 0.099167 0.02 0.496667 ‐0.25 ‐0.1 ‐0.11 0.115 ‐0.05464 ‐0.3225 0.044452799 0.325634921 9736 USP34 0.3775 0.4025 0.2375 0.1725 ‐0.0125 ‐0.2975 ‐0.0425 0 0.2575 0.029745888 0.32625 10980 COPS6 0.14 0.26 0.29 ‐0.21 0.04 0.13 ‐0.31 ‐0.04 ‐0.19 0.016714871 0.326666667 4927 NUP88 0.19 0.086667 0.61 ‐0.0366667 0.02 0 ‐0.04 ‐0.11 ‐0.02333 0.019201202 0.327222222 84056 KATNAL1 0.255 0.185 0.11 ‐0.08 0 0.075 ‐0.42 ‐0.19 ‐0.25 0.021482515 0.3275 171169 SPACA4 0.5111 0.1311 0.045875 ‐0.1289004 ‐0.0889004 ‐0.01522522 ‐0.3489 ‐0.00359 ‐0.0106 0.03138492 0.328709968 143279 HECTD2 0.205 0.015 0.475 ‐0.135 ‐0.145 ‐0.25 ‐0.09 0.03 0 0.017548928 0.33 10240 MRPS31 0.08 0.06 0.38 ‐0.32 ‐0.25 ‐0.16 ‐0.22 0 0.01 0.016698405 0.33 10845 CLPX 0.13 0.125 0.275 ‐0.38 ‐0.08 0 ‐0.075 ‐0.275 ‐0.115 0.008555193 0.330833333 9640 ZNF592 0.155 0.245 0.4 ‐0.11 ‐0.21 ‐0.235 0.225 ‐0.17 0.115 0.030637354 0.330833333 10288 LILRB2 0.09 0.12 0.29 ‐0.49 ‐0.0633333 ‐0.33 ‐0.1 ‐0.06667 0.06 0.036356807 0.331666667 57703 CWC22 0.07 0 0.39 ‐0.4 ‐0.06 ‐0.27 ‐0.28 ‐0.03 ‐0.03 0.030950085 0.331666667 346 APOC4 0.54 0.21 0.036667 ‐0.22 ‐0.02 ‐0.154 0.01 ‐0.03063 ‐0.00625 0.020683986 0.332368056 23542 MAPK8IP2 0.32 0 0.41 0.08 ‐0.04 ‐0.33 0.1 ‐0.045 ‐0.3 0.046029468 0.3325 56990 CDC42SE2 0.225 0.045 0.085 0.02 ‐0.4275 ‐0.24 ‐0.025 ‐0.38 ‐0.235 0.022496598 0.332916667 56131 PCDHB4 0.206111 ‐0.10389 0.506111 ‐0.2038889 ‐0.1348148 ‐0.13388889 0 ‐0.15917 ‐0.15122 0.029649444 0.333274691 7398 USP1 0.35 0.16 0.43 0.29 ‐0.13 0 ‐0.15 ‐0.25 0.12 0.037288217 0.333333333 3093 UBE2K 0.3 0.146667 0.326667 ‐0.2933333 ‐0.0666667 ‐0.10666667 0 0.013333 ‐3.47E‐18 0.003856529 0.333333334 342892 ZNF850P ‐0.03 0.27 0.435 0.1 ‐0.045 ‐0.305 ‐0.165 ‐0.28 0.04 0.041528272 0.334166667 81575 APOLD1 0.47 0.04 0.43 ‐0.11 0.07 0.13 0.149667 ‐0.23 ‐0.14 0.037264626 0.335055556 65005 MRPL9 0.02 0.09 0.42 ‐0.32 ‐0.29 ‐0.1 ‐0.18 0.06 ‐0.13 0.022579961 0.336666667 112950 MED8 0.24 0.35 0.16 ‐0.25 ‐0.165 ‐0.015 0.06 ‐0.08 ‐0.075 0.002711664 0.3375 7871 SLMAP 0.235 0.025 0.215 ‐0.365 ‐0.225 0.155 ‐0.355 ‐0.285 0 0.039306489 0.3375 4719 NDUFS1 0.285 0.2 0.32 ‐0.165 ‐0.08 ‐0.005 ‐0.08 0.02 ‐0.11 0.000174826 0.338333333 5090 PBX3 0.256667 0.146667 0.276667 0.2233333 ‐0.1466667 ‐0.16666667 ‐0.23 ‐0.22333 ‐0.12667 0.014318288 0.338333334 84105 PCBD2 0.42 0.15 0.3 0.19 ‐0.01 ‐0.085 ‐0.06 ‐0.14 ‐0.19 0.0088338 0.339166667 49855 SCAPER 0.12 0.485 0.325 0.1 0.025 ‐0.405 ‐0.005 0.095 0 0.036223802 0.341666667 29889 GNL2 0.07 0.11 0.67 ‐0.05 ‐0.03 ‐0.03 0 ‐0.19 ‐0.06 0.036345574 0.343333333 1185 CLCN6 0.185 0.035 0.025 ‐0.645 ‐0.27 ‐0.395 ‐0.185 0.005 ‐0.08 0.048737137 0.343333333 54785 C17orf59 0.175 0.02 0.23 0 ‐0.475 ‐0.35 ‐0.06 ‐0.29 ‐0.04 0.027433409 0.344166667 23140 ZZEF1 0 0.07 0.34 ‐0.135 ‐0.155 ‐0.335 0.02 ‐0.28 ‐0.365 0.016708228 0.345 54915 YTHDF1 0.16 0.01 0.455 0.035 ‐0.235 ‐0.055 ‐0.295 ‐0.23 ‐0.04 0.021399972 0.345 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 4929 NR4A2 0.395 0.095 0.205 ‐0.165 ‐0.06 ‐0.44 0.02 ‐0.01 ‐0.03 0.021706415 0.345833333 124359 CDYL2 0 0.356667 0.136667 0.0616667 ‐0.4733333 ‐0.05833333 ‐0.09833 ‐0.28333 ‐0.24833 0.03421953 0.347777778 7341 SUMO1 0.32 0.14 0.27 ‐0.04 ‐0.21 ‐0.24 0.2 ‐0.19 ‐0.15 0.012558612 0.348333333 27238 GPKOW 0.2 ‐0.03 0.36 ‐0.34 ‐0.23 ‐0.11 ‐0.18 0.09 ‐0.26 0.019943233 0.348333333 1417 CRYBB3 0.07 0 0.511667 ‐0.2983333 ‐0.0933333 ‐0.27833333 ‐0.18333 ‐0.07833 0.001667 0.028345601 0.348888889 6604 SMARCD3 0.24 0.22 0.55 ‐0.05 0.33 ‐0.16 ‐0.12 ‐0.08 0 0.028111736 0.35 5917 RARS 0.4 0.12 0.08 ‐0.28 ‐0.19 ‐0.19 ‐0.07 ‐0.18 0 0.005496229 0.351666667 55763 EXOC1 0.03 0.25 0.25 ‐0.375 ‐0.025 ‐0.19 0 ‐0.095 ‐0.365 0.014875644 0.351666667 10602 CDC42EP3 0.26 0 0.145 ‐0.26 0.035 ‐0.38 ‐0.335 ‐0.325 ‐0.035 0.018254948 0.351666667 3983 ABLIM1 0.13 0.2 0.75 ‐0.115 0 0 ‐0.085 0.115 0.135 0.042367486 0.351666667 159 ADSS 0.275 0.1 0.44 ‐0.06 ‐0.135 ‐0.135 ‐0.15 ‐0.025 0.01 0.002266771 0.354166667 51571 FAM49B 0.11 0.18 0.385 ‐0.425 ‐0.125 ‐0.135 ‐0.21 0.12 0 0.024113209 0.354166667 3066 HDAC2 0.12 0.16 0.68 ‐0.06 0.13 ‐0.09 ‐0.2 ‐0.04 0.05 0.035310001 0.355 515 ATP5F1 0.4 ‐0.09 0.37 0.13 ‐0.35 ‐0.18 0 ‐0.24 ‐0.13 0.045300165 0.355 5160 PDHA1 0.26 0.01 0.27 ‐0.27 ‐0.35 ‐0.32 ‐0.09 ‐0.01 ‐0.02 0.012937855 0.356666667 1653 DDX1 0.05 0.07 0.4 ‐0.08 ‐0.12 ‐0.37 0 ‐0.19 ‐0.34 0.017256689 0.356666667 4194 MDM4 0.24 0.054 0.395 0.094 ‐0.1375 ‐0.3125 ‐0.082 ‐0.328 0 0.020281888 0.357333333 4009 LMX1A 0.305 ‐0.005 0.585 0 0.15 ‐0.145 ‐0.19 0.055 ‐0.245 0.042873939 0.3575 6441 SFTPD 0.02 0.38 0.245625 ‐0.25 ‐0.31 ‐0.185 0.05 0 ‐0.16 0.013261897 0.357708333 283237 TTC9C 0.54 0.23 0.24 0.17 0.01 ‐0.08 ‐0.1 ‐0.02 ‐0.11 0.005769475 0.358333333 23598 PATZ1 0.12 0.179167 0.393333 0 ‐0.4866667 ‐0.15666667 0.186667 ‐0.16 ‐0.15667 0.040529057 0.359722222 3514 IGKC 0.238333 0.410455 0.450833 ‐0.0683333 0.135 0.10409091 0.0275 ‐0.12625 ‐0.03409 0.001828926 0.360220959 59274 MESDC1 0.06 0.12 0.17 0 ‐0.21 ‐0.22 ‐0.27 ‐0.62 ‐0.15 0.023088888 0.361666667 57478 USP31 0.16 0 0.33 0.12 ‐0.21 ‐0.44 ‐0.26 ‐0.04 ‐0.36 0.035043726 0.361666667 124808 CCDC43 0.28 0.06 0.35 0.035 ‐0.485 ‐0.08 0.17 ‐0.15 ‐0.285 0.046563004 0.3625 7112 TMPO 0.535 0.31 0.505 0.275 0.25 0.105 0 ‐0.225 0.12 0.018648813 0.3625 84333 PCGF5 0.227143 0.231429 0.305714 ‐0.2185714 0.1014286 ‐0.48071429 ‐0.11071 0.035952 0.012857 0.025781363 0.364722222 9694 TTC35 0.18 0.3625 0.27 ‐0.3575 ‐0.0575 ‐0.1375 0.0025 0 ‐0.0175 0.004798615 0.365416667 9925 ZBTB5 ‐0.285 0.085 0.095 ‐0.225 ‐0.21 ‐0.485 ‐0.515 ‐0.505 ‐0.465 0.017564143 0.365833333 9525 VPS4B 0.305 ‐0.03 0.335 0 ‐0.225 ‐0.335 0.03 ‐0.39 ‐0.055 0.027323879 0.365833333 373 TRIM23 0.315 0.305 0.16 0.015 ‐0.39 ‐0.005 0 ‐0.41 0.155 0.039133899 0.365833333 4956 ODF1 0.2905 0.0205 0.2305 ‐0.2595 ‐0.5895 0.0505 ‐0.0095 ‐0.25339 ‐0.0595 0.044448915 0.367314815 54469 ZFAND6 0.23 0.16 0.31 ‐0.35 ‐0.255 ‐0.17 0 0.05 ‐0.08 0.006419215 0.3675 27430 MAT2B 0.13 0.025 0.28 ‐0.07 ‐0.135 ‐0.3 ‐0.06 ‐0.375 ‐0.395 0.009218919 0.3675 6210 RPS15A 0.063333 0.086667 0.546667 ‐0.3633333 ‐0.1866667 ‐0.11 ‐0.06667 ‐0.08667 0 0.023852216 0.367777778 10038 PARP2 0.27 0.11 0.43 ‐0.01 0.04 ‐0.01 ‐0.26 ‐0.35 0 0.014993267 0.368333333 4731 NDUFV3 0.296667 0.013333 0.466667 ‐0.08 ‐0.2466667 ‐0.10333333 ‐0.02667 ‐0.12333 ‐0.08 0.006791626 0.368888889 64764 CREB3L2 0.515 ‐0.03 0.4 ‐0.3525 ‐0.1275 0.01 ‐0.17 0 0.1925 0.049045672 0.369583333 5130 PCYT1A 0.336667 ‐0.0075 0.303333 ‐0.0533333 ‐0.3066667 ‐0.22 ‐0.4625 0.073333 0 0.033785233 0.372361111 7626 ZNF75D 0.536667 0.108 0.375 ‐0.11 ‐0.15 ‐0.0625 0.1775 ‐0.05 0 0.010204792 0.372388889 55114 ARHGAP17 0.346667 0 0.276667 ‐0.2633333 0.0066667 ‐0.08333333 ‐0.04833 ‐0.53333 ‐0.06667 0.031879421 0.3725 84268 RPAIN 0.3125 0.13 0.46 ‐0.3175 ‐0.01 ‐0.15 0 0.0925 ‐0.0475 0.009810463 0.372916667 7258 TSPY1 0.233333 0.645 0.176667 0.0166667 ‐0.315 0.09 0 ‐0.02 0.1 0.025970178 0.373055556 60558 GUF1 0.54 0.06 0.19 0.005 ‐0.255 ‐0.215 ‐0.18 0.045 ‐0.065 0.016505053 0.374166667 339175 METTL2A 0.34 ‐0.07 0.32 0.07 ‐0.22 ‐0.36 ‐0.05 ‐0.35 ‐0.16 0.026192075 0.375 5962 RDX 0.325 0.06 0.715 ‐0.02 0.07 0 ‐0.19 ‐0.055 0.145 0.033349381 0.375 22868 FASTKD2 0.065 0.105 0.375 ‐0.16 ‐0.1 ‐0.265 ‐0.51 ‐0.015 ‐0.115 0.018108394 0.375833333 10327 AKR1A1 0.09 ‐0.035 0.68 0 ‐0.1825 ‐0.115 ‐0.0675 ‐0.18 ‐0.2425 0.044204664 0.37625 5495 PPM1B 0.115 0.09 0.58 ‐0.3 ‐0.065 ‐0.125 ‐0.115 ‐0.015 ‐0.07 0.016327383 0.376666667 51608 GET4 0.165 0.01 0.54 ‐0.015 ‐0.36 ‐0.235 0 ‐0.085 ‐0.135 0.024618113 0.376666667 54534 MRPL50 0.04 0.03 0.37 0 ‐0.6 ‐0.35 0 ‐0.11 ‐0.32 0.049811503 0.376666667 10021 HCN4 0.11 0.04 0.68625 0.01 ‐0.0888095 ‐0.03 ‐0.27 ‐0.12 ‐0.09 0.036309437 0.376884921 3658 IREB2 0.08 0.473333 0.183333 ‐0.0966667 ‐0.1866667 ‐0.04 0.193333 ‐0.31667 ‐0.34667 0.032357711 0.377777778 51028 VPS36 0 0.18 0.01 ‐0.32 ‐0.44 ‐0.08 0.01 ‐0.52 ‐0.54 0.033891398 0.378333333 663 BNIP2 ‐0.03 0.035 0.33 ‐0.405 ‐0.39 ‐0.38 ‐0.315 0.085 ‐0.2 0.025394063 0.379166667 64860 ARMCX5 0.4 ‐0.08 0.57 ‐0.15 ‐0.3 0.02 ‐0.16 0 0.09 0.043029332 0.38 79791 FBXO31 0.0975 0.06 0.47 ‐0.2875 ‐0.2075 ‐0.1625 ‐0.3175 ‐0.04 ‐0.015 0.012213291 0.380833333 123811 C16orf63 0.425 0.395 0.33 0.035 0 ‐0.05 ‐0.215 0.265 ‐0.025 0.004988668 0.381666667 30849 PIK3R4 0.155 0 0.58 0.14 ‐0.005 ‐0.12 ‐0.37 ‐0.21 ‐0.26 0.046041966 0.3825 29978 UBQLN2 0.25 0.04 0.59 ‐0.23 ‐0.04 ‐0.17 ‐0.22 0.14 ‐0.02 0.025486437 0.383333333 55922 NKRF 0.36 ‐0.08 0.39 ‐0.52 ‐0.06 ‐0.25 ‐0.08 ‐0.05 0 0.041245474 0.383333333 121053 C12orf45 0 0.22 0.44 ‐0.28 ‐0.19 ‐0.21 ‐0.18 0.03 ‐0.15 0.007762334 0.383333333 259197 NCR3 0.71 0.150167 0.26 ‐0.04 ‐0.0312963 0.07 ‐0.13 0.1 ‐0.03292 0.016601089 0.38409105 2101 ESRRA 0.33 0.19 0.29 ‐0.05 ‐0.39 ‐0.2 0.08 0 ‐0.13 0.007334223 0.385 55142 HAUS2 0.22 0.11 0.63 0.025 0 ‐0.035 ‐0.105 ‐0.14 ‐0.135 0.01086447 0.385 4706 NDUFAB1 0.27 0 0.75 ‐0.06 ‐0.12 ‐0.12 0.19 ‐0.08 ‐0.08 0.046881631 0.385 730 C7 0.17 0.575 0.23 ‐0.1616667 ‐0.065 0.02 0.145 ‐0.06167 ‐0.23833 0.012397404 0.385277778 93649 MYOCD ‐0.04667 0.26 0.5535 ‐0.21 ‐0.16 ‐0.23 ‐0.08333 ‐0.135 0.04 0.01949682 0.385333333 57486 NLN 0.369167 ‐0.0725 0.5775 ‐0.0425 0 ‐0.2275 ‐0.26 0.15 ‐0.1875 0.043652629 0.385972222 26275 HIBCH 0.26 0.05 0.365 ‐0.16 ‐0.27 ‐0.07 0 ‐0.38 ‐0.09 0.007369065 0.386666667 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 1161 ERCC8 0.645 0.145 0.055 ‐0.205 ‐0.23 ‐0.205 0.16 ‐0.15 0 0.0378981 0.386666667 1738 DLD 0.62 ‐0.03 0.2 ‐0.18 ‐0.2 ‐0.19 0 ‐0.11 ‐0.06 0.023236797 0.386666667 80119 PIF1 0.393333 0.403333 0.36 0.2866667 0.3 ‐0.09666667 ‐0.38333 ‐0.13333 0.013333 0.04336327 0.387777778 8417 STX7 0.12 0.3875 0.4675 ‐0.286 ‐0.126 ‐0.13 0 0.1625 0 0.011538067 0.38825 51277 DNAJC27 0.405 0.12 0.045 ‐0.3 ‐0.345 ‐0.165 0.12 0.015 ‐0.515 0.044221444 0.388333333 1122 CHML 0.665 0.475 0.02 0.295 0.02 ‐0.21 0 ‐0.095 ‐0.02 0.046125986 0.388333333 10349 ABCA10 0.06 0.18 0 ‐0.56 ‐0.47 ‐0.55 ‐0.02 ‐0.17 ‐0.08298 0.036417668 0.388829365 55844 PPP2R2D 0.493333 0.16 0.52 ‐0.0133333 0 0.19 0.093333 ‐0.16667 ‐0.09333 0.008497909 0.389444444 55623 THUMPD1 0.3075 0 0.235 0.1725 ‐0.35 ‐0.29 ‐0.15 ‐0.4175 ‐0.22 0.026353549 0.39 53339 BTBD1 0.52 0.01 0.38 ‐0.46 ‐0.03 ‐0.04 0 ‐0.09 0.1 0.037784718 0.39 51622 C7orf28A 0.06 0.29 0.61 ‐0.22 ‐0.04 ‐0.03 ‐0.03 0 ‐0.11 0.011428436 0.391666667 1772 DNAH14 0.093667 0.013667 0.588667 ‐0.0063333 ‐0.2230833 ‐0.25633333 ‐0.16633 ‐0.15283 ‐0.15508 0.018539292 0.392 5189 PEX1 0.41 ‐0.02 0.6 ‐0.07 ‐0.13 0 ‐0.04 ‐0.12 ‐0.02 0.015770939 0.393333333 3980 LIG3 0.276667 0.003333 0.24 0.005 ‐0.245 ‐0.475 ‐0.17 ‐0.175 ‐0.26333 0.008627505 0.393888889 84749 USP30 0.205 0.28 0.305 ‐0.425 0.24 ‐0.15 ‐0.015 0 ‐0.435 0.042043007 0.394166667 9702 CEP57 0.383333 0.223333 0.653333 0.2866667 0 ‐0.16666667 0.083333 ‐0.06 0.006667 0.014744707 0.395 56649 TMPRSS4 0.44 0.09 0.39 ‐0.07 ‐0.03 ‐0.12 ‐0.27 0 ‐0.04 0.003680172 0.395 90580 C19orf52 0.27 0.1 0.65 ‐0.28 ‐0.06 0.04 0 ‐0.07 0.04 0.017863738 0.395 4950 OCLN 0.385 0.245 0.49 0 0.2675 ‐0.23 ‐0.1325 ‐0.14 0.1025 0.01288498 0.395416667 150147 C21orf128 0.65 0.08 0.25 ‐0.03 ‐0.135 ‐0.14 ‐0.125 0.095 ‐0.08 0.014773243 0.395833333 8036 SHOC2 0.3 0.14 0.39 0.19 ‐0.43 ‐0.15 ‐0.05 0.04 ‐0.32 0.02935843 0.396666667 10623 POLR3C 0.31 0.01 0.47 0.04 ‐0.15 ‐0.25 ‐0.15 ‐0.18 ‐0.12 0.006908682 0.398333333 8518 IKBKAP 0.3 ‐0.11 0.49 0.14 ‐0.06 ‐0.22 ‐0.21 ‐0.38 ‐0.3 0.042247209 0.398333333 1810 DR1 0.03 0.365 0.655 0.07 0 ‐0.055 ‐0.375 ‐0.07 0.14 0.040836975 0.398333333 84288 EFCAB2 0.185 0.175 0.445 ‐0.085 ‐0.105 ‐0.3 0.125 ‐0.44 0.02 0.022414188 0.399166667 57622 LRFN1 0.13 0.11 0.537685 ‐0.2151667 0 ‐0.13008333 ‐0.23 ‐0.25 ‐0.02 0.009171585 0.400103395 2068 ERCC2 0.453333 0.313333 0 ‐0.2366667 ‐0.15 ‐0.04333333 0.03 ‐0.24333 ‐0.23 0.0087692 0.401111111 5516 PPP2CB 0.65 0.15 0.38 0.15 ‐0.31 ‐0.02 0.33 ‐0.07 ‐0.13 0.043740316 0.401666667 51742 ARID4B 0.225 0.14 0.46 ‐0.245 0.025 ‐0.425 ‐0.135 0 0.01 0.01407385 0.403333333 399 RHOH 0.44 0.41 0.23 ‐0.11 ‐0.11 0 ‐0.17 0.26 ‐0.13 0.006138398 0.403333333 5594 MAPK1 0.21 0.06 0.33 ‐0.46 ‐0.06 ‐0.27 ‐0.055 ‐0.125 ‐0.25 0.006721373 0.403333333 51441 YTHDF2 0.066667 0.263333 0.503333 0 ‐0.07 ‐0.25833333 ‐0.11667 ‐0.28833 ‐0.02333 0.007918374 0.403888889 51552 RAB14 0.3 ‐0.1375 0.555 ‐0.1725 ‐0.1025 ‐0.1925 ‐0.07917 ‐0.255 ‐0.1875 0.02199273 0.404027778 85453 TSPYL5 0.035 0 0.1575 ‐0.5975 ‐0.3825 ‐0.4825 ‐0.38 0.06 ‐0.26 0.022569975 0.404583333 55660 PRPF40A 0.27 0.08 0.6 0.05 ‐0.16 ‐0.2 ‐0.26 ‐0.02 0.06 0.016140014 0.405 3759 KCNJ2 0.02 0.61 0.405619 ‐0.13 ‐0.13 ‐0.04 0.08 0 ‐0.14 0.014304391 0.405206349 55501 CHST12 ‐0.035 0.59 0.47 ‐0.195 0.085 ‐0.18 ‐0.14 0.08 ‐0.05 0.026839725 0.408333333 10985 GCN1L1 0.39 0.15 0.23 ‐0.39 ‐0.11 ‐0.09 ‐0.01 ‐0.31 0 0.006581181 0.408333333 11059 WWP1 0.45 0.355 0.345 ‐0.24 ‐0.12 ‐0.24 0.205 0.235 0 0.014989511 0.41 51528 JKAMP 0.57 0.2 ‐0.02 0 0.02 ‐0.08 ‐0.13 ‐0.48 ‐0.29 0.038197226 0.41 55330 CNO 0.4 ‐0.005 0.45 ‐0.3 ‐0.315 ‐0.345 0 0.045 0.14 0.036336082 0.410833333 7428 VHL ‐0.055 0.055 0.685 ‐0.29 0 ‐0.16 ‐0.18 ‐0.35 ‐0.12 0.044294964 0.411666667 390 RND3 0.105 0.24 0.605 ‐0.335 ‐0.03 ‐0.145 ‐0.305 0.24 0 0.037550554 0.4125 9550 ATP6V1G1 0.37 0.003333 0.05 ‐0.05 ‐0.3966667 ‐0.55666667 ‐0.11 ‐0.29333 ‐0.23 0.017996285 0.413888889 2805 GOT1 0.715 0.075 0.285 0 ‐0.09 ‐0.12 0.165 ‐0.065 ‐0.225 0.02521499 0.414166667 93973 ACTR8 0.105 0.57 ‐0.025 ‐0.355 0 ‐0.15 ‐0.415 ‐0.315 0.045 0.040200153 0.415 10576 CCT2 ‐0.03 0.07 0.5 ‐0.54 ‐0.17 0 ‐0.41 ‐0.2 ‐0.09 0.036798184 0.415 130507 UBR3 0.21 0.085 0.035 ‐0.295 ‐0.51 ‐0.3 ‐0.405 ‐0.35 0.015 0.007092825 0.4175 26523 EIF2C1 0.14 0.295 0.785 0.075 0.01 ‐0.025 ‐0.065 0 ‐0.06 0.015330619 0.4175 9140 ATG12 0.315 0.18 0.23 ‐0.585 ‐0.04 ‐0.355 ‐0.14 0.06 0 0.026968525 0.418333333 10569 SLU7 0.19 ‐0.04 0.725 0.06 ‐0.035 ‐0.145 ‐0.305 ‐0.165 ‐0.17 0.040008578 0.418333333 85411 C6orf114 0.33 0.165 0.17 ‐0.1157143 ‐0.34 ‐0.66 ‐0.21 0.14125 ‐0.01 0.043279713 0.420744048 57505 AARS2 0.29 0.15 0.34 ‐0.3 ‐0.21 ‐0.21 ‐0.13 0 ‐0.12 0.000613912 0.421666667 23360 FNBP4 0.59 0.125 0.5 0.125 0.01 0.01 ‐0.205 ‐0.04 0 0.007410951 0.421666667 9541 CIR1 0.22 0.26 0.21 ‐0.55 0.01 ‐0.29 ‐0.28 ‐0.04 0 0.015703755 0.421666667 79576 NKAP 0.29 ‐0.07 0.02 ‐0.28 ‐0.15 ‐0.47 0.03 ‐0.64 ‐0.54 0.040129188 0.421666667 85476 GFM1 0.04 0.01 0.59 ‐0.13 ‐0.47 ‐0.43 0.08 ‐0.22 ‐0.08 0.048356501 0.421666667 55108 BSDC1 0.17 0.08 0.26 ‐0.39 0.02 ‐0.48 ‐0.27 ‐0.22 ‐0.18 0.006151074 0.423333333 92305 TMEM129 0.3 0.19 0.61 0.17 ‐0.02 ‐0.17 0 ‐0.17 ‐0.15 0.007852805 0.423333333 10443 N4BP2L2 0.405 0.095 0.146667 ‐0.325 0.155 ‐0.22 ‐0.56 ‐0.17 ‐0.145 0.027413564 0.426388889 7733 ZNF180 0.18 0.285 0.435 ‐0.12 ‐0.12 ‐0.245 ‐0.325 0.05 6.94E‐18 0.003279018 0.426666667 9133 CCNB2 0.5275 0.215 0.515 ‐0.02 0.12 0 0.0275 0.0025 ‐0.18167 0.001943352 0.427777778 28955 DEXI 0.08 0.21 0.71 0.11 ‐0.22 0 0.07 ‐0.24 ‐0.29 0.034414315 0.428333333 57405 SPC25 0.113333 0.363333 0.653333 ‐0.1466667 0.06 0.12333333 ‐0.00667 ‐0.3 ‐0.05 0.016286314 0.43 81573 ANKRD13C 0.29 0.23 0.27 0.08 ‐0.38 0 ‐0.56 ‐0.18 0.04 0.027078995 0.43 1353 COX11 0.348 0.078 0.528 ‐0.194 ‐0.196 0 ‐0.148 ‐0.168 0.03 0.004500647 0.430666667 255252 LRRC57 0.21 0.235 0.435 ‐0.48 ‐0.03 0.07 ‐0.2 ‐0.115 ‐0.07 0.00990105 0.430833333 8034 SLC25A16 0.05 0.33 0.335 ‐0.635 0.045 ‐0.015 ‐0.32 ‐0.23 0 0.036693162 0.430833333 222643 UNC5CL 0.335 0.175 0.615 ‐0.2482857 ‐0.045 0 ‐0.055 0.125 ‐0.115 0.006284365 0.431380952 84247 LDOC1L 0.536667 0.095 0.34 0 ‐0.1033333 ‐0.38 0.08 ‐0.145 ‐0.1 0.010795778 0.431944445 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 2138 EYA1 0.22 0.41 0.595 ‐0.145 ‐0.31 0.19 0.29 ‐0.15 ‐0.01733 0.025525184 0.432055556 168374 ZNF92 0.11 0 0.39 0 ‐0.12 ‐0.275 ‐0.575 ‐0.4 ‐0.225 0.01953081 0.4325 55213 RCBTB1 0.495 0 0.63 ‐0.275 ‐0.135 0.245 ‐0.225 0.045 0 0.038809757 0.4325 84986 ARHGAP19 0.205 0.415 0.365 0.19 ‐0.37 0 ‐0.045 ‐0.19 ‐0.215 0.010066002 0.433333333 865 CBFB 0.363333 0.266667 0.85 ‐0.14 0.0666667 ‐0.11666667 0 0.26 0.29 0.031076169 0.433333333 9197 SLC33A1 0.51 0.18 0 ‐0.58 ‐0.18 ‐0.27 ‐0.23 0 0.04 0.034231149 0.433333333 23677 SH3BP4 0.66 0.34 0.38 ‐0.165 0.285 0.045 0 ‐0.17 0.155 0.010454447 0.435 114926 C8orf40 ‐0.115 0.02 0.595 ‐0.25 0.03 ‐0.37 ‐0.175 ‐0.515 ‐0.33 0.046998586 0.435 51164 DCTN4 0.33 0.28 0.42 ‐0.03 ‐0.32 0 ‐0.2 ‐0.11 0.11 0.002590951 0.435 54529 ASNSD1 0.41 0.15 0.51 0.13 ‐0.26 ‐0.18 0 ‐0.09 ‐0.08 0.004818628 0.436666667 139341 FUNDC1 0.43 0.04 0.4 ‐0.19 ‐0.08 0 ‐0.41 ‐0.08 ‐0.12 0.007802845 0.436666667 10440 TIMM17A 0.09 0.05 0.4 ‐0.17 ‐0.19 ‐0.11 ‐0.55 ‐0.44 ‐0.09 0.014009915 0.438333333 286334 LOC286334 0.22 0.09 0.74 ‐0.26 ‐0.05 ‐0.08 0.04 ‐0.06 ‐0.12 0.018133017 0.438333333 80321 CEP70 0.62 0 0.453333 0.11 ‐0.2566667 0.03 0.156667 ‐0.45333 ‐0.07333 0.049718528 0.438888889 55768 NGLY1 0.37 0.11 0.5 ‐0.36 ‐0.34 ‐0.27 0.06 0.07 0.16 0.027812522 0.44 10199 MPHOSPH10 0 0.16 0.48 ‐0.27 0.13 ‐0.29 ‐0.33 ‐0.38 ‐0.22 0.017962048 0.44 170506 DHX36 0.3 ‐0.08 0.64 ‐0.27 ‐0.12 ‐0.31 ‐0.08 0 ‐0.15 0.023409907 0.441666667 90187 EMILIN3 0.61 0.16 0 ‐0.53 0.04 ‐0.38 ‐0.2 ‐0.05 0.01 0.045722651 0.441666667 57609 DIP2B 0.3825 0.235 0.385 ‐0.45 ‐0.06 ‐0.295 0.110833 0.0425 0 0.013020427 0.442777778 284349 ZNF283 0.3 0.28 0.3025 ‐2.08E‐17 ‐0.3375 ‐0.33666667 ‐0.0225 0 ‐0.1975 0.002689205 0.443194445 118788 PIK3AP1 0.9011 0.1611 0.1911 0.0210996 0.0041381 ‐0.01522522 ‐0.1489 ‐0.00359 ‐0.0106 0.029470653 0.443278567 80975 TMPRSS5 0.07 0.06 0.24 ‐0.69 0.04 ‐0.35 ‐0.45 ‐0.48 0 0.039171215 0.445 9474 ATG5 0.55 0.145 0.385 ‐0.36 0.085 0.08 ‐0.245 ‐0.07 0 0.012332162 0.445 83706 FERMT3 0.37 ‐0.025 0.205 ‐0.13 ‐0.09 ‐0.535 ‐0.12 0 ‐0.7 0.04708344 0.445833333 28512 NKIRAS1 0.44 0.375 0.29 ‐0.1 0 ‐0.11 ‐0.06 ‐0.095 ‐0.1 7.13959E‐06 0.445833333 3028 HSD17B10 ‐0.015 0.16 0.395 ‐0.61 ‐0.25 ‐0.07 ‐0.34 ‐0.155 ‐0.175 0.014452668 0.446666667 84340 GFM2 0 0.39 0.73 ‐0.05 0.12 ‐0.17 ‐0.18 ‐0.16 0 0.023890074 0.446666667 27161 EIF2C2 0.4875 0.256667 0.455 0.0075 ‐0.0966667 0.01333333 ‐0.35333 0.16 ‐0.01667 0.00540287 0.447361111 84455 EFCAB7 0.54 ‐0.045 0.71 0.05 ‐0.085 ‐0.275 0.145 ‐0.065 ‐0.045 0.035264513 0.4475 38 ACAT1 0.445 0 0.675 0.135 ‐0.12 ‐0.135 0.19 ‐0.135 ‐0.38 0.041580354 0.4475 7490 WT1 0.27 0.065 0.495 ‐0.155 ‐0.6 0.165 ‐0.01 ‐0.385 ‐0.04 0.04606917 0.4475 84443 FRMPD3 0 0.3 0.59 ‐0.32 ‐0.24 ‐0.22 ‐0.08 0.07 ‐0.12 0.014502433 0.448333333 57558 USP35 0.55 0.07 0.08 ‐0.45 0.01 ‐0.4 ‐0.22 ‐0.3 0.07 0.029559538 0.448333333 83636 C19orf12 0.25 0.445 0.36 ‐0.245 ‐0.295 ‐0.265 0.215 0 0.01 0.009680635 0.448333333 55014 STX17 0.28 0.2 0.37 ‐0.21 ‐0.13 ‐0.45 ‐0.09 ‐0.12 0 0.002475146 0.45 10850 CCL27 0.67 ‐0.07 0.44 ‐0.49 0.0081667 ‐0.03777778 0.09 ‐0.13 ‐0.06204 0.047485311 0.450274691 7127 TNFAIP2 0.585 0.155 0.315 0.245 0.025 ‐0.51 ‐0.305 ‐0.125 0.075 0.043511936 0.450833333 56261 GPCPD1 0.09 0.36 0.1 ‐0.48 ‐0.15 ‐0.29 ‐0.46 ‐0.23 0 0.008360902 0.451666667 51127 TRIM17 0.14 0 0.36 ‐0.745 ‐0.32 0.05 ‐0.01 ‐0.24 ‐0.445 0.047183867 0.451666667 51474 LIMA1 0.58 ‐0.09 0.31 0.06 ‐0.14 ‐0.24 0 ‐0.52 ‐0.28 0.038960139 0.453333333 8563 THOC5 0.16 0.135 0.76 ‐0.1 ‐0.36 0.025 0.06 ‐0.135 ‐0.105 0.025390097 0.454166667 84984 C3orf34 0.57 0.075 0.695 0.14 ‐0.07 ‐0.015 ‐0.055 0 ‐0.05 0.010829406 0.455 3298 HSF2 0.195 0.2325 0.7475 ‐0.045 0 ‐0.135 0.11 ‐0.01 ‐0.3 0.015778605 0.455 60496 AASDHPPT 0.25 0.283333 0.563333 ‐0.22 ‐0.04 ‐0.09 ‐0.18333 0 ‐0.00667 0.001090916 0.455555555 10434 LYPLA1 0.456667 ‐0.02 0.766667 0.0933333 0 ‐0.12 0 ‐0.21333 ‐0.08667 0.026785165 0.455555556 51122 COMMD2 0.52 0.07 0.44 0 ‐0.25 ‐0.01 ‐0.22 ‐0.03 ‐0.17 0.004941278 0.456666667 220992 ZNF485 0.05 0.38 0.33 ‐0.05 ‐0.38 ‐0.41 ‐0.33 0.09 ‐0.14 0.012976511 0.456666667 84953 MICALCL 0.68 0.345 ‐0.13 ‐0.015 ‐0.31 ‐0.25 ‐0.25 0 ‐0.135 0.032711032 0.458333333 29957 SLC25A24 0.675 0.44 0 ‐0.22 0.14 ‐0.415 0.035 0.11 ‐0.175 0.041117032 0.459166667 78988 MRP63 0.21 0.25 0.395 ‐0.505 ‐0.135 0.005 ‐0.41 0 ‐0.005 0.013624972 0.46 9889 ZBED4 0.68 ‐5.20E‐18 0.59 ‐0.1066667 0.2366667 ‐0.05 ‐0.10667 ‐0.06333 ‐0.14 0.024903303 0.461666667 83940 TATDN1 0.146667 0.113333 0.75 ‐0.3966667 ‐0.11 ‐0.07 ‐0.16 ‐0.06667 0.053333 0.02509297 0.461666667 10884 MRPS30 0.455 0.065 0.525 ‐0.025 ‐0.32 ‐0.025 0.03 ‐0.065 ‐0.28 0.008809439 0.4625 3313 HSPA9 0.263333 0.183333 0.638333 ‐0.2866667 ‐0.11 ‐0.26666667 0 ‐0.04667 0.1 0.00889063 0.463333333 219285 SAMD9L 0.69 0.17 0.59 ‐0.3 ‐0.12 ‐0.07 0.27 0.08 0.25 0.028654576 0.465 8805 TRIM24 0.43 0.41 0.38 0 0.01 ‐0.02 ‐0.29 ‐0.1 0.05 0.000431728 0.465 9821 RB1CC1 0.291667 0.191667 0.863333 0.0441667 0.1266667 ‐0.12333333 ‐0.05833 ‐0.01 ‐0.08083 0.015919954 0.465833333 11017 SNRNP27 ‐0.01 0.255 0.64 ‐0.545 ‐0.03 ‐0.13 ‐0.24 0 ‐0.08 0.030730155 0.465833333 7163 TPD52 0.47 ‐0.11333 0.583333 ‐0.2633333 0 ‐0.13 0.056667 ‐0.38333 ‐0.2 0.03015258 0.466666667 220042 C11orf82 0.68 0.03 0.29 0.085 ‐0.14 ‐0.04 ‐0.12 ‐0.375 ‐0.215 0.01941703 0.4675 55681 SCYL2 0.25 0.15 0.15 ‐0.51 ‐0.18 ‐0.51 ‐0.21 ‐0.05 ‐0.25 0.004466865 0.468333333 2743 GLRB 0.41 0.38 0.52 ‐0.07 0.345 0.06 0 ‐0.06 ‐0.465 0.021323887 0.468333333 1355 COX15 0.26 0.19 0.715 0.135 ‐0.11 ‐0.07 0 ‐0.2 ‐0.24 0.010425557 0.469166667 23232 TBC1D12 0.245 0.52 0.605 0.005 0.115 ‐0.105 ‐0.215 0.165 ‐0.045 0.003693994 0.47 81786 TRIM7 0 0.531667 0.93 ‐0.13 0.1066667 ‐0.10833333 ‐0.06667 0.136667 0.156667 0.04461556 0.471388889 11334 TUSC2 ‐0.11 ‐0.1 0.48 ‐0.43 ‐0.6 ‐0.62 ‐0.48 ‐0.16 0 0.047274154 0.471666667 93058 COQ10A 0.22 0.55 0.4 ‐0.03 ‐0.36 ‐0.01 0.1 0 ‐0.2 0.005022429 0.473333333 84272 YIPF4 0.185 0.14 0.56 ‐0.475 0.24 ‐0.53 ‐0.11 0 ‐0.195 0.045206207 0.473333333 55686 MREG 0.125 0.255 0.525 0 ‐0.04 ‐0.295 ‐0.3 ‐0.14 ‐0.255 0.003569997 0.473333333 400569 MED11 0.6 ‐0.07 0.3 ‐0.44 ‐0.32 0.09 ‐0.27 0 ‐0.24 0.030296849 0.473333333 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 374407 DNAJB13 0.114389 0.289514 0.903889 ‐0.2261111 ‐0.1638889 0.09388889 ‐0.01611 0.163889 ‐0.07611 0.034148318 0.473337963 9927 MFN2 0.61 0.03 0.39 0.09 ‐0.36 ‐0.18 ‐0.23 ‐0.12 0.01 0.014685454 0.475 23132 RAD54L2 0.205 0.21 0.55 ‐0.105 0 ‐0.27 ‐0.375 ‐0.135 ‐0.035 0.004159022 0.475 1021 CDK6 0.574 0.316 0.44 0.27 ‐0.062 ‐0.174 ‐0.056 ‐0.17 0 0.003304209 0.475333333 80110 ZNF614 0.23 0.493333 0.335 0.005 ‐0.33 ‐0.15666667 ‐0.19 ‐0.18667 0.12 0.003124663 0.475833333 151194 FAM119A 0.07 ‐0.06 0.49 ‐0.46 ‐0.13 ‐0.27 ‐0.54 ‐0.16 ‐0.3 0.01365191 0.476666667 9597 SMAD5OS ‐0.05 0.28 0.69 0.084375 ‐0.36125 ‐0.2865625 0 ‐0.1325 ‐0.32611 0.031663062 0.477008102 22926 ATF6 0.043333 0.426667 0.875 0.0766667 ‐0.0333333 ‐0.31 ‐0.06 0.063333 0.09 0.033825079 0.477222222 79836 LONRF3 ‐0.04 0.57 0.52 0.205 ‐0.075 ‐0.205 ‐0.43 ‐0.27 0.01 0.036456 0.4775 55099 FLJ10232 0.41 0.04 0.719896 ‐0.28 0.08 ‐0.06 ‐0.04 ‐0.08 ‐0.14767 0.01414115 0.477909722 56853 CELF4 0.1 0.46 0.173333 0.015 0.015 ‐0.6 ‐0.17667 ‐0.16 ‐0.495 0.026409827 0.478055556 1164 CKS2 0.53 0.236667 0.733333 0.1933333 0.0333333 0.11 ‐0.11333 0 ‐0.10333 0.004854765 0.48 255919 TMEM188 0.54 0.15 0.27 0 ‐0.02 ‐0.45 ‐0.01 ‐0.42 ‐0.06 0.01445428 0.48 93492 TPTE2 0.31 0.08 0.47 ‐0.54 ‐0.126875 ‐0.10537037 0.2 ‐0.3 ‐0.29 0.023046524 0.480374228 54988 ACSM5 0.308148 0.081481 0.167648 ‐0.8018519 0.0481481 ‐0.16318519 ‐0.48185 ‐0.32185 ‐0.05185 0.040177468 0.481166667 25852 ARMC8 0.135 0.2575 0.6025 ‐0.305 ‐0.1975 0 ‐0.25417 ‐0.0825 ‐0.0625 0.004328377 0.481944445 115294 PCMTD1 0.2115 0.288 0.416 ‐0.074 0.028 ‐0.038 ‐0.1485 ‐0.606 ‐0.224 0.011322034 0.48225 5445 PON2 0.1 0.12 0.82 0.08 0.09 ‐0.31 ‐0.04 ‐0.33 ‐0.31 0.043603875 0.483333333 5373 PMM2 0.195 0.28 0.32 ‐0.595 ‐0.35 0 ‐0.265 ‐0.04 ‐0.065 0.010402565 0.484166667 9421 HAND1 ‐0.02 0 0.49 ‐0.1827778 ‐0.64 ‐0.67 ‐0.27 ‐0.01 ‐0.2 0.040314824 0.485462963 64087 MCCC2 0.265 ‐0.07 0.435 ‐0.065 ‐0.625 ‐0.025 ‐0.39 ‐0.225 ‐0.325 0.021366142 0.485833333 57679 ALS2 0.2975 0.313333 0.586667 0.1225 0.06 ‐0.0725 ‐0.52 ‐0.1 ‐0.0175 0.013716612 0.487083333 117854 TRIM6 0.456667 0.576667 0.5 ‐0.3633333 0.17 0.05333333 ‐0.17 0.093333 0.356667 0.015835616 0.487777778 23590 PDSS1 0.42 0.32 0.64 0.07 ‐0.26 ‐0.19 0.1 0.11 0 0.003510644 0.488333333 79071 ELOVL6 0.8 0.44 0 ‐0.08 ‐0.01 ‐0.11 ‐0.38 0.14 ‐0.01 0.032224913 0.488333333 1058 CENPA 0.67 0.248 0.826 0.506 0.302 0.148 ‐0.154 ‐0.244 0 0.047426225 0.488333333 23548 TTC33 0.313333 0.293333 0.606667 ‐0.2966667 ‐0.1666667 0 ‐0.05667 ‐0.11 0.12 0.002711258 0.489444445 6390 SDHB 0.3 0.27 0.39 ‐0.13 ‐0.04 ‐0.15 ‐0.17 ‐0.22 ‐0.31 7.20317E‐05 0.49 6198 RPS6KB1 0.35 0.262 0.506 0.054 ‐0.124 ‐0.022 ‐0.002 ‐0.458 ‐0.156 0.004535825 0.490666667 23279 NUP160 0.135 0.38 0.71 ‐0.14 ‐0.015 ‐0.29 0.14 ‐0.025 ‐0.17 0.010132491 0.491666667 85364 ZCCHC3 0.295 0.33 0.2 ‐0.665 0 ‐0.36 ‐0.095 ‐0.02 ‐0.165 0.015275154 0.4925 10466 COG5 0.59 0.26 0.42 ‐0.24 0.09 0.05 ‐0.26 0 ‐0.06 0.002631033 0.493333333 23759 PPIL2 0.7175 0.175 0.145 0.075 ‐0.225 ‐0.64166667 0.158333 ‐0.1325 ‐0.12167 0.048775578 0.49375 54993 ZSCAN2 0.263333 0.331667 0.656667 0 ‐0.1266667 ‐0.11833333 0.016667 ‐0.20833 ‐0.03667 0.001214991 0.496111111 23219 FBXO28 0.51 0.27 ‐0.07 ‐0.24 ‐0.13 0.05 ‐0.39 ‐0.65 ‐0.2 0.028405865 0.496666667 7783 ZP2 0.16 0.23 0.05 ‐0.45 ‐0.23 ‐0.49 ‐0.91 0 ‐0.02 0.048291252 0.496666667 25814 ATXN10 0.581667 0 0.573333 0.1933333 ‐0.21 ‐0.24333333 0.083333 ‐0.22333 ‐0.28333 0.023911342 0.498888889 51559 NT5DC3 0.553333 0.106667 0.526667 0.0633333 ‐0.5233333 0.12666667 0.14 ‐0.25 ‐0.18 0.029418183 0.499444445 22796 COG2 0.26 0.096667 0.766667 ‐0.1366667 ‐0.14 0 0.01 ‐0.22333 ‐0.26667 0.011846777 0.500555556 8187 ZNF239 0.33 0 0.48 ‐0.29 ‐0.19 ‐0.22 ‐0.6 0.05 ‐0.16 0.014805776 0.505 330 BIRC3 0.365 0.33 0 ‐0.505 ‐0.29 ‐0.345 ‐0.645 0.05 0.095 0.034210788 0.505 6416 MAP2K4 0.513333 0.35 0.33 ‐0.3133333 ‐0.0833333 ‐0.29 0.106667 0 ‐0.06667 0.001975897 0.505555555 10479 SLC9A6 0.49 0.49 0.255 ‐0.19 ‐0.15 ‐0.09 ‐0.09 0 ‐0.05 0.00011234 0.506666667 90417 C15orf23 0.44 0.31 0.91 0.15 0.23 0.19 ‐0.26 ‐0.02 ‐0.01 0.01650618 0.506666667 80746 TSEN2 0.17 0.22 0.66 0 ‐0.13 ‐0.39 ‐0.29 0.03 ‐0.19 0.008436237 0.511666667 84632 AFAP1L2 0.45 0.25 0.73 ‐0.36 ‐0.03 0.04 0 ‐0.03 0.16 0.007470565 0.513333333 79954 NOL10 0.01 0.48 0.53 0.085 ‐0.55 ‐0.225 ‐0.22 ‐0.105 ‐0.025 0.019410685 0.513333333 56998 CTNNBIP1 0.8 0.31 0.27 ‐0.08 0.295 0 ‐0.095 ‐0.23 ‐0.215 0.014764176 0.514166667 286046 XKR6 0.16 0.78 0.43 ‐0.23 0.01 ‐0.04633333 ‐0.145 ‐0.0882 0.15 0.008229608 0.514922222 8850 KAT2B 1.048333 0.291667 0.158333 0.1983333 0.1083333 0 ‐0.035 ‐0.30167 ‐0.065 0.042521322 0.515277778 54165 DCUN1D1 0.215 ‐0.07 0.43 ‐0.29 ‐0.69 ‐0.38 0.055 ‐0.31 ‐0.33 0.019335036 0.515833333 10105 PPIF 0 0.04 0.38 ‐0.75 ‐0.48 ‐0.36 ‐0.35 ‐0.13 ‐0.19 0.012328601 0.516666667 10575 CCT4 0.655 ‐0.065 0.675 ‐0.255 ‐0.08 ‐0.05 ‐0.215 0.03 0 0.020672259 0.516666667 2526 FUT4 0.04 ‐0.08 0.305 ‐0.085 ‐0.205 ‐0.745 ‐0.6 ‐0.115 ‐0.825 0.044871709 0.5175 3612 IMPA1 0.596667 0.196667 0.42 ‐0.1633333 ‐0.2333333 ‐0.09666667 0 ‐0.03333 ‐0.15667 0.000790667 0.518333334 10907 TXNL4A 0.07 0.175 0.78 ‐0.315 ‐0.29 0.05 ‐0.61 0.1 0 0.049708736 0.519166667 80219 COQ10B 0.475 ‐0.065 0.095 0.105 ‐0.535 ‐0.235 ‐0.675 ‐0.235 ‐0.53 0.035591111 0.519166667 79960 PHF17 0.055 0.375 0.82 ‐0.195 0.2 0.02 ‐0.5 ‐0.145 0 0.037911742 0.52 5912 RAP2B 0.395 0.12 0.61 ‐0.27 ‐0.185 ‐0.135 ‐0.605 0.325 0 0.039243145 0.52 26269 FBXO8 0.51 0.28 0.42 0 ‐0.01 ‐0.3 ‐0.17 ‐0.28 0.05 0.001300563 0.521666667 1207 CLNS1A 0.5 0.07 0.89 0.02 ‐0.04 0 0.15 ‐0.15 ‐0.21 0.018963947 0.525 8669 EIF3J 0.12 0.22 0.28 ‐0.31 ‐0.54 ‐0.27 ‐0.26 ‐0.19 ‐0.35 0.000267288 0.526666667 23560 GTPBP4 0.25 0.16 0.53 ‐0.14 ‐0.3 ‐0.26 ‐0.12 ‐0.37 ‐0.09 0.001117661 0.526666667 375035 SFT2D2 0.335 0.265 0.39 ‐0.255 ‐0.255 ‐0.405 ‐0.27 0 ‐0.005 0.001116701 0.528333333 112495 GTF3C6 0.01 0.07 0.85 ‐0.42 ‐0.26 ‐0.17 ‐0.41 ‐0.09 0.04 0.038445937 0.528333333 889 KRIT1 0.47 0 0.58 ‐0.62 ‐0.16 ‐0.115 0.27 ‐0.345 ‐0.1 0.040856581 0.528333333 7670 ZNF117 0.66 0.02 0 ‐0.11 ‐0.71 ‐0.17 0.05 ‐0.57 ‐0.31 0.049391796 0.53 10447 FAM3C 0.722 0.274 ‐0.018 0.032 0 ‐0.37 0.02 ‐0.4 ‐0.51 0.035625244 0.530666667 1737 DLAT 0.19 0.163333 0.5 ‐0.7133333 ‐0.05 ‐0.15 ‐0.54 0 ‐0.03333 0.028921077 0.532222222 84331 FAM195A 0.28 0.02 0.97 ‐0.44 ‐0.22 ‐0.05 0 ‐0.09 0.14 0.046295617 0.533333333 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 55605 KIF21A 0.028571 0.181429 0.662857 ‐0.1714286 ‐0.3157143 ‐0.39 ‐0.58714 0.162619 ‐0.16571 0.029488044 0.535515873 9650 MTFR1 0.37 ‐0.06 0.93 0.2033333 ‐0.17 ‐0.12333333 ‐0.25333 ‐0.10667 ‐0.28333 0.041231559 0.535555556 11345 GABARAPL2 0.32 0.255 0.705 ‐0.255 0.045 ‐0.08 ‐0.2 ‐0.19 0.025 0.002741138 0.535833333 8504 PEX3 0.46 0.09 0.815 ‐0.05 0.175 0.025 ‐0.255 ‐0.09 ‐0.29 0.016994385 0.535833333 8048 CSRP3 0.28625 0.008125 1.05625 ‐0.1834722 ‐0.099375 0.00625 0 ‐0.14675 ‐0.09375 0.038044779 0.536391204 84418 C5orf32 0 0.11 0.69 ‐0.23 ‐0.23 ‐0.38 ‐0.31 ‐0.3 ‐0.17 0.008178523 0.536666667 196515 FLJ30092 0.66 0.52 0.15 ‐0.07 ‐0.035 ‐0.015 ‐0.185 ‐0.07 ‐0.19 0.00171783 0.5375 27304 MOCS3 0.27 0.27 0.06 ‐0.39 0.03 ‐0.3 ‐0.63 ‐0.49 ‐0.25 0.006960137 0.538333333 167227 DCP2 0.695 0 0.015 ‐0.4 ‐0.29 ‐0.23 ‐0.265 ‐0.36 ‐0.27 0.010255149 0.539166667 115426 UHRF2 0.315 0.2225 0.515 ‐0.4425 0.0275 ‐0.055 ‐0.7425 0.0575 0.02 0.033298415 0.54 221078 NSUN6 0.38 0.06 0.62 ‐0.61 ‐0.08 ‐0.15 0.05 ‐0.27 ‐0.06 0.017677455 0.54 11319 ECD 0.32 0.06 0.95 0 ‐0.21 ‐0.29 0.16 ‐0.14 ‐0.1 0.029174117 0.54 163786 SASS6 0.07 0.1 0.58 ‐0.51 0 ‐0.37 ‐0.4 ‐0.59 0.13 0.032927368 0.54 79443 FYCO1 0.66 0 0.62 0.09 0.14 ‐0.4 0.06 ‐0.33 ‐0.25 0.029977628 0.541666667 5471 PPAT 0.415 0.45 0.41 ‐0.02 0.065 ‐0.175 ‐0.25 ‐0.185 ‐0.14 0.000117278 0.5425 54931 RG9MTD1 0.06 0.36 0.73 ‐0.29 ‐0.07 ‐0.28 ‐0.3 ‐0.02 ‐0.02 0.008777146 0.546666667 2744 GLS 0 0.42 0.163333 ‐0.8533333 ‐0.3966667 ‐0.47666667 ‐0.35667 ‐0.04 0.003333 0.031252769 0.547777778 79736 C17orf42 0.665 0.14 0.565 ‐0.15 ‐0.215 ‐0.26 0.06 0 0.01 0.004247482 0.549166667 30061 SLC40A1 0.4795 0.0975 0.6225 0.1675 ‐0.2475 ‐0.3945 0.27 ‐0.54 ‐0.1525 0.037691566 0.549333333 9221 NOLC1 0.292 0 1.096 0.042 ‐0.31 ‐0.162 0.054 ‐0.044 ‐0.106 0.047721771 0.550333333 51290 ERGIC2 0.3 0.17 0.47 0 ‐0.08 ‐0.54 ‐0.03 ‐0.45 ‐0.33 0.007867594 0.551666667 6103 RPGR 0.72 ‐0.15 0.69 ‐0.24 ‐0.32 ‐0.33 0.1 0 0 0.038910965 0.551666667 26128 KIAA1279 0.53 0.32 0.54 0 0.06 ‐0.17 ‐0.22 ‐0.39 0.19 0.004558511 0.551666667 79831 JMJD5 0 0.265 0.265 0.12 ‐0.28 ‐0.33 ‐0.35 ‐0.6 ‐0.82 0.027053303 0.553333333 130916 MTERFD2 0.033333 0.403333 0.713333 ‐0.32 ‐0.26 0 ‐0.53 0.123333 ‐0.04333 0.02393861 0.555 285237 C3orf38 0.53 0.22 0.74 ‐0.28 ‐0.07 0.05 0 ‐0.06 0.01 0.002556176 0.555 55885 LMO3 ‐0.045 0.74 0.740333 ‐0.49 0.2416667 ‐0.02 ‐0.105 0 ‐0.09 0.041166256 0.555666667 222484 LNX2 0.42 0.04 0.81 ‐0.25 ‐0.14 0 ‐0.46 0.02 0.03 0.020185621 0.556666667 10308 ZNF267 0.123333 0.776667 0.31 0 ‐0.2966667 ‐0.33666667 0.26 ‐0.30333 ‐0.24333 0.022047953 0.556666667 7019 TFAM 0.6 ‐0.04 1.04 0 ‐0.24 ‐0.12 0.29 ‐0.03 ‐0.04 0.046581482 0.556666667 1027 CDKN1B 0.4925 0.2975 0.5675 ‐0.1475 ‐0.12 ‐0.2475 ‐0.06 0 ‐0.0525 0.000135918 0.557083333 51132 RLIM 0.313333 0.103333 0.641667 ‐0.4133333 ‐0.1666667 ‐0.08 ‐0.56833 0.051667 ‐0.05333 0.015324103 0.557777778 112849 C14orf149 0.8 0.135 0.57 0 ‐0.14 ‐0.04 ‐0.005 ‐0.13 ‐0.03 0.003999798 0.559166667 125476 INO80C 0.31 0.31 0.36 ‐0.7 ‐0.21 ‐0.02 ‐0.07 ‐0.34 ‐0.06 0.008422825 0.56 10006 ABI1 0.515 0.045 0.245 ‐0.225 ‐0.57 0.05 ‐0.84 ‐0.045 ‐0.12 0.040825361 0.56 441052 LOC441052 0.9795 0.241375 0.5395 0.2395 ‐0.0305 0.0695 ‐0.1505 ‐0.013 0.036643 0.009919515 0.561517857 1070 CETN3 0.37 0.47 0.35 ‐0.51 0.07 ‐0.17 ‐0.42 0.04 0 0.007323126 0.561666667 23271 CAMSAP1L1 0.23 0.3 0.16 ‐0.37 ‐0.47 ‐0.59 ‐0.6 0 0.04 0.013992874 0.561666667 79018 C17orf39 0.42 0.28 0.54 ‐0.71 ‐0.26 ‐0.13 ‐0.07 0.13 0.15 0.023859621 0.561666667 80155 NAA15 0.22 0.335 0.8325 ‐0.3525 ‐0.195 ‐0.095 0.145 0 ‐0.0975 0.00962103 0.561666667 54065 FAM165B 0.296667 0.053333 1.096667 ‐0.1633333 ‐0.0966667 ‐0.28 ‐0.18667 0.243333 0 0.046994585 0.562777778 26994 RNF11 0.48 0.15 0.6 ‐0.2 ‐0.25 ‐0.11 ‐0.15 ‐0.04 ‐0.17 0.000710095 0.563333333 55131 RBM28 0.37 0.08 0.65 0.13 ‐0.45 ‐0.16 ‐0.45 ‐0.23 ‐0.02 0.014860356 0.563333333 6201 RPS7 0 0.14 0.76 ‐0.44 ‐0.1 ‐0.3 ‐0.5 ‐0.04 ‐0.2 0.020172867 0.563333333 79647 AKIRIN1 0.535 0.165 0.29 0 ‐0.185 ‐0.26 ‐0.72 ‐0.06 ‐0.18 0.012322532 0.564166667 284340 CXCL17 0.04 0.111905 0.77 0.0479286 ‐0.24375 ‐0.55 ‐0.43 ‐0.29407 ‐0.077 0.026164126 0.565117505 84825 MGC5370 0.14 0.12 0.79 ‐0.56 ‐0.17 0.02 ‐0.1325 ‐0.16 ‐0.29 0.018682593 0.565416667 154043 CNKSR3 0.235 0.25 0.615 ‐0.1 ‐0.31 0 ‐0.36 ‐0.295 ‐0.135 0.001923193 0.566666667 29915 HCFC2 0.41 0.42 0.66 ‐0.43 0.02 0.12 ‐0.29 ‐0.18 0.34 0.015329663 0.566666667 79898 ZNF613 0.995 0.33 0.23 0.03 ‐0.115 ‐0.125 0 0.125 ‐0.21 0.013610434 0.5675 22934 RPIA 0.13 0.04 0.66 ‐0.4 ‐0.4 ‐0.27 ‐0.39 ‐0.2 ‐0.09 0.006399389 0.568333333 5993 RFX5 0.55 0.22 0.46 ‐0.03 ‐0.17 ‐0.4 0.15 ‐0.29 ‐0.22 0.003697862 0.57 83478 ARHGAP24 0.995 0.165 0.24 ‐0.14 0.0816667 ‐0.32 ‐0.055 ‐0.285 0.095 0.026285308 0.570555556 57763 ANKRA2 0.23 0.2975 0.86 ‐0.465 0.3725 ‐0.23166667 0 ‐0.0375 ‐0.2875 0.034163977 0.570694445 28970 C11orf54 0.32 0.255 0.47 ‐0.505 0.01 ‐0.155 ‐0.435 ‐0.315 0.065 0.005858238 0.570833333 57509 MTUS1 0.37 0.366 0.656 ‐0.68 0.132 0.094 0 0.118 ‐0.316 0.026640379 0.572666667 8847 DLEU2 0.795 0.135 0.645 0 ‐0.645 0.115 0.115 ‐0.015 0.13 0.035354067 0.575 200895 DHFRL1 0.535 0 0.45 0.005 ‐0.06 ‐0.1 ‐0.71 ‐0.52 ‐0.1 0.026866489 0.575833333 90025 UBE2CBP 0.08 0.07 1.04 0 ‐0.4 ‐0.4 ‐0.08 ‐0.21 0.01 0.046308925 0.576666667 121536 AEBP2 0.375 0 0.995 ‐0.215 ‐0.0016667 ‐0.225 0.115 ‐0.225 ‐0.175 0.027624735 0.577777778 55151 TMEM38B 0.475 0.085 0.86 0.08 ‐0.25 ‐0.16 ‐0.04 ‐0.21 ‐0.05 0.009663634 0.578333333 64844 40244 0.89 0.07 0.39 ‐0.11 ‐0.31 ‐0.24 ‐0.26 ‐0.29 0.44 0.041460296 0.578333333 7093 TLL2 0.116667 1.73E‐18 0.39 ‐0.1633333 ‐0.22 ‐0.55 0.053333 ‐0.62 ‐0.96 0.041723838 0.578888889 26998 FETUB 0.331111 0.141111 0.632611 ‐0.1938889 ‐0.6988889 ‐0.25888889 0 ‐0.13889 0.021111 0.015607696 0.579851852 2653 GCSH 0.16 0 0.98 ‐0.17 ‐0.51 ‐0.36 ‐0.07 0 ‐0.1 0.039456231 0.581666667 92285 ZNF585B 0.407083 0.647083 ‐0.08292 ‐0.0329167 ‐0.2629167 ‐0.45291667 0 ‐0.44292 ‐0.36292 0.016003764 0.582847222 56902 PNO1 0.05 0.015 0.9 ‐0.27 ‐0.38 ‐0.34 0 ‐0.27 ‐0.31 0.025282842 0.583333333 4193 MDM2 0.2475 0.485 0.135 0.0408333 ‐0.315 ‐0.9625 ‐0.01917 ‐0.01 ‐0.5125 0.046846348 0.585555556 571 BACH1 0.27 0.27 0.61 ‐0.57 0.01 ‐0.47 0.05 0 ‐0.24 0.012622012 0.586666667 23133 PHF8 0.446667 0.154167 0.671667 0.0633333 ‐0.2658333 ‐0.40833333 ‐0.31083 ‐0.02833 ‐0.02583 0.005829373 0.586805556 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 84874 ZNF514 1.14 0.265 0 2.78E‐17 ‐0.4 ‐0.23 ‐0.16 0.04 0.015 0.048814333 0.590833333 219899 TBCEL 0.06 0.45 0.43 ‐0.35 ‐0.17 0 ‐0.38 ‐0.14 ‐0.63 0.006939294 0.591666667 5194 PEX13 ‐0.09 0.535 0.71 ‐0.47 0.01 ‐0.085 ‐0.61 ‐0.17 0.08 0.035794288 0.5925 26225 ARL5A 0.455 0 0.025 ‐0.29 ‐0.285 ‐0.415 ‐0.32 ‐0.605 ‐0.71 0.004383129 0.5975 9648 GCC2 0.316667 0.293333 0.65 ‐0.0616667 ‐0.1566667 ‐0.27 ‐0.135 ‐0.16167 ‐0.28833 0.000313174 0.598888889 7771 ZFP112 0.53 0.11 0.36 ‐0.15 0.09 ‐0.72 ‐0.37 ‐0.02 ‐0.43 0.01799802 0.6 57472 CNOT6 ‐0.02 ‐0.075 0.6125 0.0425 ‐0.1525 ‐0.8875 ‐0.3925 ‐0.7325 ‐0.46 0.048582745 0.602916667 81689 ISCA1 0.49 0 0.173333 ‐0.04 ‐0.5833333 ‐0.35333333 0.003333 ‐0.86667 ‐0.48 0.027747769 0.607777778 81554 WBSCR16 0.733333 0.073333 0.706667 ‐0.45 ‐0.2466667 0.30333333 ‐0.38 ‐0.23 0.373333 0.047675825 0.609444445 80255 SLC35F5 0.46 0.295 0.41 ‐0.275 0.09 ‐0.14 ‐0.095 ‐0.69 ‐0.22 0.006512979 0.61 26127 FGFR1OP2 0.145 0.315 0.8 ‐0.315 ‐0.125 ‐0.115 ‐0.61 0.02 0 0.015263201 0.610833333 2976 GTF3C2 0.08 0.4 1.04 ‐0.43 ‐0.03 ‐0.23 0 ‐0.03 0.085 0.025539433 0.6125 10724 MGEA5 0.09 0.44 0.87 ‐0.16 0.07 ‐0.32 ‐0.22 ‐0.04 ‐0.22 0.00853433 0.615 5238 PGM3 0.42 0.56 0.56 ‐0.43 0 0.03 ‐0.54 0.29 0.03 0.01452162 0.616666667 84450 ZNF512 0.285 ‐0.06 0.855 0.04 ‐0.25 ‐0.605 0.085 ‐0.325 ‐0.5 0.037385564 0.619166667 84816 RTN4IP1 0.3 0.22 0.87 ‐0.31 ‐0.41 0.05 0 ‐0.11 ‐0.16 0.008397264 0.62 84950 PRPF38A 0.015 0.22 0.85 ‐0.215 ‐0.405 ‐0.34 ‐0.325 ‐0.115 ‐0.155 0.010204841 0.620833333 10802 SEC24A 0.77 0.05 0.85 0 ‐0.17 0.37 ‐0.49 ‐0.03 ‐0.11 0.032081319 0.628333333 11080 DNAJB4 0.725 0.525 0.625 0 ‐0.365 ‐0.25 0.22 0.245 0.125 0.004937566 0.629166667 11232 POLG2 0.36 0.05 0.41 ‐0.95 ‐0.01 ‐0.55 ‐0.66 0 0.02 0.045484712 0.631666667 9470 EIF4E2 ‐0.31 0.24 0.39 ‐0.68 ‐0.61 ‐0.42 ‐0.64 ‐0.33 ‐0.47 0.005937496 0.631666667 5464 PPA1 0.12 ‐0.015 1.175 ‐0.125 ‐0.145 ‐0.16 ‐0.16 ‐0.315 ‐0.345 0.040294226 0.635 8487 SIP1 0.45 0.3 0.88 ‐0.07 ‐0.15 ‐0.09 0 ‐0.16 ‐0.09 0.001063204 0.636666667 9406 ZRANB2 0.125 0.32 0.875 0.025 ‐0.205 ‐0.175 ‐0.48 ‐0.005 ‐0.345 0.011407531 0.6375 54205 CYCS 0.410667 0.234667 0.781667 0.0016667 ‐0.1533333 ‐0.27533333 0.046667 ‐0.14083 ‐0.46533 0.00424731 0.640083333 9330 GTF3C3 0.38 0.025 0.92 ‐0.095 ‐0.15 ‐0.285 ‐0.01 ‐0.185 ‐0.47 0.0135889 0.640833333 80298 MTERFD3 0.24 0.25 1.14 0 ‐0.09 ‐0.14 ‐0.1 ‐0.14 ‐0.13 0.014039729 0.643333333 57002 C7orf36 0.24 0.35 0.56 ‐0.7 0 0.06 ‐0.75 ‐0.11 ‐0.07 0.024554121 0.645 4135 MAP6 0.32 0.69 0.69 0.0312963 0.18 ‐0.34 ‐0.05 ‐0.15 ‐0.15 0.001873616 0.646450617 9841 ZBTB24 0.445 ‐0.01 1.27 0 ‐0.245 0.085 ‐0.105 ‐0.215 ‐0.005 0.039675377 0.649166667 87178 PNPT1 0.485 ‐0.005 1.115 ‐0.02 ‐0.435 0 ‐0.405 ‐0.065 0.215 0.041321267 0.65 23335 WDR7 0.44 0.21 0.72 ‐0.42 ‐0.34 ‐0.26 0 ‐0.14 0 0.002628249 0.65 114038 C21orf84 0.19 0.36 ‐0.18 ‐1.11 ‐0.29 ‐0.67 0.02 ‐0.75 ‐0.37 0.040306984 0.651666667 996 CDC27 0.69 0.34 0.6 0.23 ‐0.12 ‐0.31 0.03 ‐0.49 0 0.006088102 0.653333333 145258 GSC 0.1 0.06 1.08 ‐0.245 ‐0.32 ‐0.35 0.08 ‐0.4 ‐0.21 0.030135218 0.654166667 8883 NAE1 0.2 0.24 0.86 ‐0.38 0.12 0 ‐0.66 ‐0.11 ‐0.3 0.020462997 0.655 29113 C6orf15 1.34 0.01 0.515 ‐0.16 ‐0.12 ‐0.12 0 0.115 0.085 0.041670891 0.655 123722 FSD2 ‐0.05 0.29 0.69 ‐0.91 ‐0.13 ‐0.41 ‐0.64 0 0.02 0.04274229 0.655 26354 GNL3 0.585 0 0.855 ‐0.2 ‐0.37 ‐0.34 ‐0.145 ‐1.73E‐18 ‐0.01 0.010600546 0.6575 7181 NR2C1 0.425 0.295 0.965 ‐0.235 0.055 0 ‐0.145 0.025 ‐0.305 0.004536015 0.6625 51379 CRLF3 0.776667 0.203333 0.626667 ‐0.0933333 ‐0.0433333 ‐0.10333333 ‐0.05 ‐0.2 ‐0.27333 0.001112166 0.662777778 5565 PRKAB2 0.138 0.202 0.8155 ‐0.394 ‐0.12 ‐0.3545 ‐0.436 ‐0.144 ‐0.218 0.004723215 0.662916667 8874 ARHGEF7 0.245 0 0.545 ‐0.295 ‐0.15 ‐0.46 ‐1.2 ‐0.14 ‐0.175 0.040146435 0.666666667 51427 ZNF107 0.721667 0.136667 0.603333 ‐0.0383333 ‐0.2466667 ‐0.03333333 ‐0.56667 ‐0.10667 ‐0.08667 0.005596369 0.666944445 4893 NRAS 0.733333 0.22 0.34 ‐0.3333333 ‐0.2966667 ‐0.29 ‐0.01333 ‐0.14 ‐0.34667 0.001259829 0.667777778 8821 INPP4B 0.413333 0.453333 0.216667 ‐0.5066667 ‐0.46 ‐0.56 0.4 0.076667 ‐0.79333 0.044195151 0.668333333 9739 SETD1A 1.02 0.1 0.39 ‐0.2 ‐0.59 0 ‐0.15 0.06 ‐0.12 0.020313649 0.67 195828 ZNF367 0.133333 0.88 0.54 ‐0.1833333 ‐0.4166667 ‐0.08 ‐0.61333 0.331667 0.036667 0.028652004 0.671944444 257415 FAM133B 0.04 0.333333 0.983333 ‐0.4433333 ‐0.1066667 ‐0.41 ‐0.46333 0.093333 ‐0.00667 0.023574045 0.675 54784 ALKBH4 0.08 0.07 0.78 ‐0.41 ‐0.4 ‐0.47 0 ‐0.38 ‐0.53 0.009352546 0.675 10436 EMG1 0.51 ‐0.045 0.895 0.135 ‐0.655 ‐0.355 0.315 ‐0.375 ‐0.41 0.048269735 0.6775 26260 FBXO25 0.54 0.085 1.225 ‐0.135 ‐0.02 ‐0.07833333 0 ‐0.09833 ‐0.045 0.01726045 0.679444444 143379 C10orf82 0.54 0.18 0.42 ‐0.43 ‐0.68 ‐0.7 0.28 ‐0.15 ‐0.12 0.023609308 0.68 79624 C6orf211 0.52 0 0.98 0.08 ‐0.44 ‐0.36 0.17 ‐0.35 ‐0.18 0.024865863 0.68 55617 TASP1 0.84 0.17 0.35 0.01 ‐0.15 ‐0.99 ‐0.04 ‐0.03 ‐0.16 0.035801371 0.68 51029 PPPDE1 0.475 0.305 0.98 0.185 ‐0.04 0.175 0.025 ‐0.175 ‐0.73 0.02646841 0.68 8050 PDHX 0.68 0.5 0.27 ‐0.44 ‐0.47 ‐0.2 0.22 ‐0.31 ‐0.01 0.006164283 0.685 118987 PDZD8 1.08 0.55 0 ‐0.17 0.01 ‐0.12 ‐0.6025 0.27 ‐0.24 0.037234304 0.685416667 27145 FILIP1 0.485 0.585 0.331667 ‐0.315 ‐0.0216667 ‐0.12 ‐0.395 0.401667 ‐0.865 0.031920544 0.686388889 140459 ASB6 0.2 0 1.01 ‐0.07 ‐0.13 0.1 ‐0.87 ‐0.315 ‐0.435 0.047391133 0.69 9894 TELO2 0.17 0.09 1.24 ‐0.25 ‐0.08 ‐0.23 ‐0.41 ‐0.21 0.03 0.03197188 0.691666667 84189 SLITRK6 0.05 0.72 0.19 ‐0.06 ‐0.96 0 0.051429 ‐0.7 ‐0.57 0.046732624 0.693095238 9589 WTAP 0.5675 0.0475 0.94 ‐0.12 ‐0.3275 ‐0.21 0.2025 ‐0.265 ‐0.33 0.012455541 0.693333333 55039 TRMT12 0.11 0.14 0.97 ‐0.9 ‐0.38 ‐0.37 ‐0.01 0.08 ‐0.14 0.042670838 0.693333333 57001 ACN9 ‐0.09 0.16 0.86 ‐0.69 0 ‐0.21 ‐0.9 ‐0.21 ‐0.3 0.039472066 0.695 51616 TAF9B 0.82 0 0.46 0.305 ‐0.45 ‐0.775 0.04 ‐0.5 ‐0.24 0.042282245 0.696666667 10600 USP16 0.38 0 1.21 ‐0.28 ‐0.36 ‐0.36 0.13 ‐0.15 ‐0.01 0.031949435 0.701666667 54149 C21orf91 0.225 0.18 1.235 0.08 ‐0.38 ‐0.155 0 ‐0.09 ‐0.385 0.027718611 0.701666667 661 POLR3D 0.475 0.04 0.57 ‐0.68 ‐0.72 ‐0.365 0.095 0 ‐0.375 0.017713497 0.7025 285367 RPUSD3 0.22 0.62 0.2 ‐1.02 ‐0.29 0 0.01 ‐0.1 ‐0.75 0.036052302 0.705 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 10827 FAM114A2 0.545 0.3 0.67 ‐0.21 0 ‐0.04 ‐0.245 ‐0.49 ‐0.22 0.000823062 0.705833333 5902 RANBP1 0.25 0.1 1.43 0.04 ‐0.21 ‐0.2 0 ‐0.21 ‐0.1 0.041354077 0.706666667 23609 MKRN2 0.51 0.28 0.89 ‐0.32 0 ‐0.09 ‐0.2 ‐0.15 ‐0.12 0.001113584 0.706666667 64137 ABCG4 0.225 0.19 1.46 ‐0.255 ‐0.065 ‐0.135 ‐0.13 0 0.09 0.040781131 0.7075 4677 NARS 0.26 0.11 0.69 ‐0.39 ‐0.32 ‐0.62 ‐0.32 ‐0.27 ‐0.22 0.001538926 0.71 58513 EPS15L1 0.17 0.78 1.21 0.04 ‐0.08 ‐0.1 0 0.43 ‐0.26 0.021087311 0.715 51805 COQ3 0.42 0.18 1.37 0.05 ‐0.06 ‐0.11 ‐0.08 0 ‐0.16 0.02110381 0.716666667 23176 40429 0.9 0.71 0.2 ‐0.43 ‐0.05 0 ‐0.2 ‐0.14 0.13 0.005047931 0.718333333 402573 C7orf61 0.402222 0.372222 0.372222 ‐1.1677778 ‐0.1077778 ‐0.15666667 ‐0.56778 0 ‐0.01778 0.033890238 0.718518519 9738 CP110 0.585 ‐0.06 1.145 ‐0.125 ‐0.38 0 0.05 ‐0.565 0.04 0.033989461 0.72 223082 ZNRF2 0.38 0.645 0.815 0 ‐0.215 ‐0.43 0.435 ‐0.095 ‐0.34 0.009134384 0.720833333 23086 EXPH5 0.88 0 0.845 0.3366667 0.08 ‐0.21333333 ‐0.01333 ‐0.7 ‐0.395 0.040446356 0.725833333 8493 PPM1D 0.136667 0.363333 1.066667 ‐0.4166667 0.11 ‐0.46 ‐0.39333 ‐0.01667 ‐0.05667 0.017356129 0.727777778 7559 ZNF12 0.69 0.24 0.53 ‐0.35 0.06 ‐0.45 ‐0.34 0.05 ‐0.43 0.003049399 0.73 96626 LIMS3 0.49 ‐0.05 0.81 ‐0.21 ‐0.37 ‐0.19 ‐1.15 0 0.04 0.049720693 0.73 11339 OIP5 0.62 0.53 0.75 ‐0.36 ‐0.23 ‐0.1 0 ‐0.1 0.2 0.00054823 0.731666667 11244 ZHX1 0.63 0.08 0.81 0.02 ‐0.47 ‐0.19 ‐0.17 ‐0.53 ‐0.02 0.007609059 0.733333333 420 ART4 0.268 0.403 0.573 ‐0.867 0.268 ‐0.902 ‐0.217 0.178 ‐0.397 0.045755739 0.7375 9783 RIMS3 0.3 0.35 0.93 ‐0.205 ‐0.09 ‐0.115 ‐0.69 ‐0.19 0 0.007035017 0.741666667 135114 HINT3 0.52 0.17 0.65 ‐0.45 ‐0.49 ‐0.33 ‐0.67 0.1 0.03 0.008180246 0.748333333 9205 ZMYM5 0.63 0.38 1.06 ‐0.16 ‐0.12 0.12 ‐0.31 0 0.11 0.002584026 0.75 1657 DMXL1 0.753333 0.09 0.403333 ‐0.11 0.07 ‐1.005 ‐0.12 ‐0.84333 0 0.0433666 0.750277778 8723 SNX4 0.65 ‐0.04 0.99 ‐0.16 ‐0.4 ‐0.69 0.31 ‐0.35 ‐0.02 0.034024217 0.751666667 132720 C4orf32 0.165 0.245 1.135 ‐0.535 ‐0.155 ‐0.245 ‐0.41 0 ‐0.08 0.015586537 0.7525 133584 EGFLAM 0.744833 0 1.254833 ‐0.4251667 0.0748333 ‐0.07516667 ‐0.05517 0.034833 ‐0.0704 0.0235138 0.752595238 157627 LOC157627 0.058661 0.598661 0.688661 ‐0.0413393 ‐0.3113393 ‐0.68133929 ‐0.44134 0.108661 ‐0.46134 0.010320469 0.753333333 902 CCNH 0.595 0.275 1.11 ‐0.065 ‐0.16 ‐0.16 0 ‐0.1 ‐0.08 0.002435211 0.754166667 84549 MAK16 0.23 0.37 0.94 0 ‐0.49 ‐0.07 ‐0.48 ‐0.17 ‐0.26 0.004967368 0.758333333 1767 DNAH5 0.71 ‐0.015 0.2045 ‐0.505 0.135 ‐0.885 ‐0.615 0.03 ‐0.915 0.040634909 0.759 4976 OPA1 0.68 0.3 0.68 0.255 ‐0.295 0 ‐0.68 ‐0.095 ‐0.46 0.009648363 0.765833333 388272 C16orf87 0.67 0.32 0.84 ‐0.51 ‐0.23 ‐0.35 ‐0.05 0.05 0.15 0.003809645 0.766666667 23203 PMPCA 0.14 0.46 1.49 0 ‐0.15 0.03 ‐0.11 ‐0.01 ‐0.19 0.025616766 0.768333333 5994 RFXAP 0.51 0.03 0.97 0.065 0.215 ‐0.37 ‐0.66 ‐0.75 ‐0.09 0.034958568 0.768333333 63941 NECAB3 0.46 0.21 0.58 ‐0.86 ‐0.54 ‐0.3 ‐0.26 ‐0.39 0.22 0.010834806 0.771666667 23587 C17orf81 0.35 0.17 1.64 ‐0.15 ‐0.02 ‐0.01 ‐0.12 ‐0.01 ‐0.04 0.038113342 0.778333333 81627 C1orf25 0.525 0.42 0.46 ‐0.52 0.075 ‐0.385 ‐1.085 0 0.045 0.023622703 0.78 54800 KLHL24 0.82 0.345 0.71 0 ‐0.32 ‐0.7 0.145 ‐0.01 ‐0.065 0.006605388 0.783333333 22849 CPEB3 0.125 0.37 1.36 ‐0.13 ‐0.2 ‐0.58 0.09 ‐0.12 ‐0.065 0.026721187 0.785833333 5980 REV3L 0.26 0.04 0.61 ‐0.33 ‐0.05 ‐0.77 ‐1.11 ‐0.38 ‐0.26 0.017761031 0.786666667 6926 TBX3 0.145 0.06 1.329 ‐0.2075 ‐0.555 ‐0.12 0.19 ‐0.555 ‐0.407 0.043046464 0.787083333 83640 FAM103A1 0.25 0.26 0.475 ‐0.465 ‐0.155 ‐0.44 ‐0.455 ‐0.805 ‐0.465 0.000545542 0.7925 400579 FLJ35934 0.313148 0.393148 0.223148 ‐1.2068519 ‐0.3368519 ‐0.94685185 ‐0.38685 0.003148 ‐0.05685 0.029567795 0.798333333 200095 C1orf67 0.28 0.37 1.17 ‐0.23 ‐0.5 ‐0.36 0 ‐0.14 0.05 0.008904988 0.803333333 25898 RCHY1 0.61 0.37 0.17 ‐0.69 ‐0.24 ‐0.14 ‐0.41 ‐0.67 ‐0.38 0.001356054 0.805 84693 MCEE 0.59 0.24 0.63 ‐0.53 0 ‐0.28 ‐0.91 ‐0.27 0.08 0.010318247 0.805 7701 ZNF142 0.46 0.46 0.84 0.21 ‐0.39 ‐0.39 ‐0.66 ‐0.31 0.19 0.00865009 0.811666667 81796 SLCO5A1 0.1775 1.4275 0.2275 ‐0.2989286 0.0075 ‐0.7125 ‐0.34625 ‐0.0325 0.1575 0.041311902 0.815029762 5911 RAP2A 0.315 0.65 0.59 ‐0.125 0.22 ‐0.57 ‐0.47 ‐0.555 ‐0.285 0.004107932 0.815833333 58495 OVOL2 0.667143 0.737143 ‐0.12286 0 ‐0.7928571 ‐0.92285714 ‐0.11286 ‐0.25286 ‐0.28286 0.024654086 0.821190476 64089 SNX16 0.85 1.125 0.565 0.285 0 ‐0.01 ‐0.02 0.185 ‐0.295 0.001315486 0.8225 150275 CCDC117 0.95 0.49 1 0.38 ‐0.03 0.14 0 ‐0.41 ‐0.15 0.003519338 0.825 51499 TRIAP1 0 0.685 0.965 ‐0.46 0 0.235 ‐0.63 ‐0.325 ‐0.485 0.018775244 0.8275 9666 DZIP3 0.7 0.23 1.17 0.1933333 ‐0.3066667 ‐0.23333333 0.01 ‐0.1 ‐0.33333 0.00634093 0.828333333 139760 GPR119 0.18 0.06 0.19 ‐0.94 ‐0.18 ‐1.23 ‐1.15 ‐0.74 0.13 0.039731584 0.828333333 115399 LRRC56 0.37 0.36 1.04 ‐0.24 0 ‐0.53 ‐0.3 ‐0.15 ‐0.22 0.002511055 0.83 90624 LYRM7 0.366667 0.52 1.363333 ‐0.2433333 0 ‐0.16666667 0.25 ‐0.18 ‐0.17333 0.008460003 0.835555556 93145 OLFM2 0.27 0.24 0.777037 ‐0.26 ‐0.72 0.13 ‐1.16 0 ‐0.445 0.029533857 0.838179012 55631 LRRC40 0.42 0.22 1.3 ‐0.78 0.21 ‐0.08 ‐0.65 0 0.15 0.039543867 0.838333333 1491 CTH 0.28 0 0.85 ‐1.1 ‐0.17 ‐0.27 ‐1.11 ‐0.03 ‐0.1 0.043928511 0.84 144195 SLC2A14 ‐0.03 0 0.89 ‐0.17 ‐0.7 ‐0.81 ‐0.56 ‐0.42 ‐0.67 0.010069226 0.841666667 219790 RTKN2 0.323333 0.34 1.503333 ‐0.3533333 ‐0.35 ‐0.02 ‐0.125 0.103333 0.026667 0.019996307 0.841944444 5562 PRKAA1 0.9 0.77 0.28 ‐0.36 0 ‐0.4 ‐0.26 ‐0.07 ‐0.07 0.001142306 0.843333333 5166 PDK4 0.4525 0.8525 1.2925 ‐0.2008333 0.5775 ‐0.1375 ‐0.2125 ‐0.1925 0.29 0.01284033 0.845138889 4603 MYBL1 1.36 0.583333 0.433333 ‐0.0966667 ‐0.0016667 ‐0.02 0.108333 ‐0.31167 0 0.004579803 0.845833333 6683 SPAST 0.5 0.605 1.385 ‐0.22 0 0 ‐0.715 0.52 0.32 0.031712402 0.845833333 220001 VWCE 0.46 0.71 0.88 ‐0.6 ‐0.27 ‐0.3 0 0 0.19 0.002686986 0.846666667 57380 MRS2 0.19 0.26 0.01 ‐0.79 ‐0.45 ‐0.55 ‐1.01 ‐0.85 ‐0.52 0.000527005 0.848333333 55138 FAM90A1 0.8 ‐0.19241 0.91 ‐0.905 0.08 ‐0.515 ‐0.135 ‐0.595 0 0.034837449 0.850864198 56967 C14orf132 0.42 0.265 0.89 ‐0.1666667 0 ‐0.87666667 0.426667 ‐0.5975 ‐0.75667 0.033827857 0.853472222 5357 PLS1 0.31 0.6 1.49 0.42 0 ‐0.245 ‐0.68 ‐0.195 0.37 0.039819314 0.855 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 126272 EID2B 0.27 0.47 0.71 ‐0.88 ‐0.05 0 ‐1.14 0 ‐0.17 0.028821363 0.856666667 55803 ADAP2 0.08 0.215 1.22 ‐0.655 0 ‐0.32 ‐0.555 ‐0.11 ‐0.535 0.018327008 0.8675 55500 ETNK1 0.185 ‐0.17 1.015 0.335 ‐0.69 ‐1.035 ‐0.685 ‐0.5 ‐0.585 0.045506601 0.87 81543 LRRC3 0.286 0.826 0.906 ‐0.134 ‐0.2275714 ‐0.22129167 0.244333 0.034889 ‐0.894 0.01279139 0.872273479 160897 GPR180 0.228333 0.686667 1.115 ‐0.0123333 0.145 ‐0.25166667 ‐0.46167 ‐0.37167 ‐0.22333 0.004844291 0.872611111 3975 LHX1 0.168889 0.138889 0.528889 ‐0.5511111 ‐0.2611111 ‐0.85111111 0 ‐1.65111 ‐0.34111 0.042650069 0.888148148 55900 ZNF302 1.016667 0.356667 0.87 0.48 ‐0.02 ‐0.86 0.073333 ‐0.42 ‐0.13667 0.021142253 0.895 55664 CDC37L1 0.89 0.3 0.78 ‐0.31 ‐0.29 ‐0.305 ‐0.39 ‐0.195 0.01 0.000436513 0.903333333 57535 KIAA1324 0.47 0.26 0.14 ‐0.63 0 ‐0.99 0.015 ‐1.36 ‐0.715 0.029487312 0.903333333 5366 PMAIP1 0.593333 0.3 0.866667 ‐0.4366667 ‐0.3933333 ‐0.52666667 ‐0.48667 0 ‐0.16333 0.000797287 0.921111111 25871 C3orf17 0.195 0.405 0.505 ‐0.35 0.065 ‐1.045 ‐0.94 0.005 ‐1.06 0.023551264 0.9225 93134 ZNF561 0.52 0.21 0.685 ‐0.595 ‐0.785 ‐0.605 0.02 ‐0.26 ‐0.52 0.002077576 0.929166667 80063 ATF7IP2 0.325 0.355 1.24 ‐0.125 ‐0.58 ‐0.95 0.405 0 ‐0.545 0.03153043 0.939166667 84532 ACSS1 0.335 ‐0.045 1.025 0.025 ‐0.73 ‐0.425 ‐0.455 ‐0.985 ‐0.45 0.013709264 0.941666667 9829 DNAJC6 0.313194 0.380417 0.990417 ‐0.2595833 0 ‐0.74958333 ‐0.34775 ‐0.06718 ‐0.86958 0.007693625 0.943621914 440145 C13orf37 0.345 0.26 0.9 0.14 0.085 0 ‐0.91 ‐1.325 ‐0.645 0.044647835 0.944166667 79899 PRR5L 1.62 0.26 1.42 ‐0.17 ‐0.21 0.25 0.12 0.52 0.42 0.024418127 0.945 79946 C10orf95 0.44 0 1.56 ‐0.73 ‐0.27 ‐0.5 ‐0.16 ‐0.2 0.14 0.030516322 0.953333333 55731 C17orf63 0.255 0.445 1.05 ‐1.125 ‐0.33 ‐0.445 ‐0.395 0.03 0 0.013941442 0.960833333 83551 TAAR8 1.37 0.99 0.3 0.0410417 ‐0.5 0.04 ‐0.03 ‐0.02 0 0.005058859 0.964826389 123904 NRN1L 1.14 0.19 0.65 0.17 ‐0.57 ‐1.05 ‐0.39 0.46 ‐0.45 0.03498012 0.965 8803 SUCLA2 0.8 0.655 0.835 ‐0.89 0 ‐0.325 0.17 ‐0.145 ‐0.03 0.003716892 0.966666667 122622 ADSSL1 0.675 ‐0.015 0.46 ‐0.325 ‐0.23 0 ‐1.475 ‐1.225 ‐0.395 0.036231398 0.981666667 84078 KBTBD7 0.34 0.03 0.85 ‐1 ‐0.7 ‐0.47 ‐0.45 ‐0.22 ‐0.62 0.003091722 0.983333333 54905 CYP2W1 0.15 0.87 0.56 ‐0.2155556 ‐1.27 ‐1.04 ‐0.14 ‐0.31 0.21 0.031081996 0.987592593 340719 NANOS1 0.32 0.37 0.81 0.05 0.04 ‐0.72 ‐1.14 ‐0.39 ‐0.84 0.014051477 1 90423 ATP6V1E2 0.41 0.27 1.595 ‐0.33 ‐0.22 ‐0.48 ‐0.395 ‐0.235 0.185 0.013912878 1.004166667 114876 OSBPL1A 0.88 ‐0.05 1.68 ‐0.07 ‐0.035 ‐0.27 0.085 ‐0.81 0.085 0.034847171 1.005833333 54014 BRWD1 0.795 0.2275 0.7875 0 0.015 ‐0.875 ‐0.74083 ‐0.025 ‐0.7925 0.010466861 1.006388889 440133 LOC440133 0.67 0.76 0.97 0 ‐0.08 ‐0.38 0.22 0.04 ‐1.05 0.008586912 1.008333333 2352 FOLR3 0.966222 0.696222 0.081222 0.1262222 ‐0.7187778 ‐0.01877778 ‐0.50378 ‐0.34878 ‐1.11378 0.016430049 1.010833333 122060 SLAIN1 0.48 0.16 1.85 0.07 ‐0.27 ‐0.54 0.28 ‐0.52 ‐0.18 0.034480954 1.023333333 8660 IRS2 0.464 0.322 1.987 ‐0.256 ‐0.018 ‐0.05 ‐0.3505 0 0.078 0.025684977 1.02375 133746 JMY 0.47 0.05 1.375 ‐0.67 ‐0.345 ‐0.79 0 ‐0.445 ‐0.105 0.014136261 1.024166667 80823 BHLHB9 1.46 0.31 0.97 ‐0.0561111 ‐0.0995 0.22 ‐0.01222 ‐0.3 ‐0.45 0.005353076 1.029638889 2529 FUT7 ‐0.04383 1.19 1.3 ‐0.13 0.21 ‐0.2 ‐1.17 ‐0.05148 0.003333 0.037067167 1.03841358 257054 LOC257054 0.805 0.63 0.98 ‐0.21 0.19 ‐0.19 ‐0.465 ‐0.27 ‐0.465 0.000314973 1.04 143496 OR52B4 ‐0.05 1.69 1.47 0 ‐0.18 ‐0.03 0.01 ‐0.14188 0.32 0.027042872 1.0403125 64795 RMND5A 0.49 0.6925 1.375 ‐0.235 0.295 ‐0.0525 ‐0.6775 ‐0.1175 ‐0.4025 0.005294385 1.050833333 10234 LRRC17 1.59 0 0.455 0.105 ‐0.9 ‐0.29 0.06 ‐0.175 ‐1.185 0.044702631 1.079166667 840 CASP7 0.13 ‐0.01333 0.846667 ‐0.5933333 ‐0.4533333 ‐0.47666667 ‐0.97667 ‐1.11333 ‐0.94 0.003032323 1.08 6322 SCML1 0.676667 0.46 1.39 0 0.0133333 ‐0.38666667 ‐0.67 ‐0.38667 ‐0.01 0.003454652 1.082222223 3209 HOXA13 0.17 0 1.77 ‐0.41 ‐1.02 ‐0.64 0.09 ‐0.33 ‐0.35 0.038870459 1.09 388695 LYSMD1 1.45 ‐0.1 1.34 ‐0.4 ‐0.36 ‐0.24 0.03 0.06 ‐0.27 0.01619419 1.093333333 683 BST1 ‐0.12111 0.088889 0.368889 ‐0.6911111 ‐1.7011111 ‐0.82111111 ‐1.23111 ‐0.72111 ‐0.80111 0.003397109 1.106666667 126668 TDRD10 0.41375 0.23375 1.188036 ‐1.48625 ‐1.20625 ‐0.1775 ‐0.12625 0.015 ‐0.0325 0.039183598 1.114136905 2784 GNB3 0.53 0.17 0.8 0 ‐0.49 ‐0.62 ‐1.94 ‐0.18 ‐0.47 0.034832006 1.116666667 2842 GPR19 0.3625 0.1725 0.261204 ‐1.6975 ‐0.3875 0.0925 ‐0.6775 ‐0.7175 ‐1.7275 0.037188811 1.117901235 284459 HKR1 0.79 0.33 0.43 ‐0.32 ‐0.08 0 ‐1.77 ‐1.14 ‐0.37 0.032757215 1.13 7029 TFDP2 0.52 0.27 0.635 ‐1.65 ‐0.68 ‐0.485 0.09 ‐0.92 ‐0.31 0.016514301 1.134166667 1380 CR2 0.33 0.28 1.12 ‐1.45 ‐0.3 ‐1.42 ‐0.31 ‐0.13 0.26 0.043016704 1.135 57020 C16orf62 0.6425 1.1825 1.065 ‐0.0808333 0 ‐0.2575 ‐0.2625 ‐0.7275 0.205 0.001144301 1.150555556 2828 GPR4 0.31 0.23 0.94 ‐0.44 ‐0.18 ‐0.875 ‐0.66 ‐1.16 ‐0.675 0.002407455 1.158333333 27063 ANKRD1 0.24 1.155 0.705 ‐0.48 0 0.585 ‐1.56 ‐0.785 ‐0.595 0.040412018 1.1725 8646 CHRD 1.65 ‐0.255 1.415 ‐0.9 0.075 0 ‐0.745 ‐0.105 0.165 0.041548005 1.188333333 85458 DIXDC1 0.11 0.18 1.44 ‐0.21 0 ‐1.4 ‐0.22 ‐1.16 ‐0.75 0.030301223 1.2 57643 ZSWIM5 0.6 0.95 0.93 ‐0.97 ‐0.91 ‐0.95 ‐0.45 0.89 0 0.028775643 1.225 55640 FLVCR2 0.86 0.97 1.08 ‐0.06 ‐0.53 ‐0.04 0.169286 ‐1.13 0.04 0.004204245 1.228452381 57691 KIAA1586 1.72 1.07 0.9 0 0 ‐0.1 0.17 ‐0.27 ‐0.09 0.000231263 1.278333333 1755 DMBT1 1.56 1.17 0.57 0.23 0.41 ‐0.29 ‐0.78 ‐0.6 ‐0.1 0.006296277 1.288333333 28968 SLC6A16 0.72 1.62 1.27 ‐0.32 0.45 ‐0.12 ‐0.11241 0 ‐0.61 0.001811107 1.322067901 84302 C9orf125 0.565 0.24 1.52 ‐0.35 ‐0.7 ‐1.82 0.49 ‐0.865 ‐0.05 0.042216093 1.324166667 79149 ZSCAN5A 0.47 0.33 1.29 ‐0.57 ‐1.14 ‐1.44 0.2 ‐0.33 ‐0.84 0.010808857 1.383333333 668 FOXL2 0.0075 0.893333 1.763333 ‐0.2566667 0.3933333 ‐0.87666667 0.153333 ‐0.69667 ‐1.93667 0.049654099 1.424722222 4811 NID1 0.155 0.375 2.935 0.115 ‐0.6416667 ‐0.67833333 0 ‐0.125 ‐0.58167 0.049515025 1.473611111 8825 LIN7A 0.375 0.275 1.255 ‐0.99 ‐1.675 0 0.21 ‐0.67 ‐2.275 0.039548875 1.535 79633 FAT4 1.29 1.08 0.96 ‐0.51 ‐0.37 ‐1.03 ‐1.52 0.07 0.6 0.01086534 1.57 157567 ANKRD46 0.84 ‐0.05 1.02 ‐0.67 ‐1.22 ‐1.26 ‐0.56 ‐1.38 ‐0.82 0.001105608 1.588333333 169200 TMEM64 0.832 0.894 1.406 0 0.058 0.066 ‐0.978 ‐1.332 ‐1.13 0.006119562 1.596666667 3764 KCNJ8 0.22 0 2.62 ‐0.37 ‐1.46 ‐0.40375 0.14 ‐1.67 ‐1.4 0.037578263 1.807291667 Supplementary Table S1. Downregulated genes by miR‐206 (via microarrays) Entrez GeneID GeneSymbol 206 (5) 206 (10) 206 (15) Dharma (1) Dharma (6) Dharma (11) Scr (2) Scr (7) Scr (12) p(206‐con) (206‐con) 59336 PRDM13 ‐0.02244 0.45 4.45 ‐0.63 ‐1.15 ‐1.58 ‐0.68 0 ‐0.95 0.04086897 2.457518519 3589 IL11 0.6 ‐0.41333 ‐3.23 0.3466667 0.93 0.87666667 0.436667 0.08 ‐0.03 0.106988293 ‐1.454444445 Supplementary Table S2 Based on the information of clinical breast tumor data set METABRIC (1, 2), pairwise correlation analysis between miR-206 and TWF1 if miR-206 expression <7, star* suggests significant observations (p=0.0032, n=1300).

| miR-206 ------+------twf1 | -0.0816* (coefficient) | P= 0.0032 | n= 1300

Pairwise correlation analysis miR-206 and TWF1 if miR-206<7 & pam50_subtype=="LumB", star* suggests significant observations (p=0.0397, n=354)

| miR-206 ------+------twf1 | -0.1094* (coefficient) | P=0.0397 | n= 354