Capacity-Building for Health Research in Developing Countries: a Manager’S Approach
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The Cochrane Afraid to Challenge the Diagnostic Acu- Men Ofhis Ancestors Or Peers
place or at the wrong time. He was not The Cochrane afraid to challenge the diagnostic acu- men ofhis ancestors or peers. He Collaboration believed that clinical questions often were answered on the basis oftests, Lessons for Public Health rather than on common sense. Practice and Evaluation? Obstetrics offered Cochrane an example ofthe practices ofthe day. Like many other fields ofmedicine, MIRUAM ORLEANS, PHD obstetrics adhered to treatments that perhaps were oftraditional or emo- tional value but which had little basis Archie Cochrane undoubtedly in science. The therapeutic use ofiron wanted to reach providers of and vitamins, the basis for extended health care with his ideas, but he lengths ofstay in hospitals following probably never thought that he would childbirth, and the basis for deciding father a revolution in the evaluation of how many maternity beds were needed medical practices. in Britain were all questioned by In his book ofonly 92 pages, Cochrane, who believed that these "Effectiveness and Efficiency: Random matters could and should be investi- Reflections on Health Services," pub- gated in trials. lished by the Nuffield Provincial Hos- Although Cochrane was by no pitals Trust in 1972, he cast a critical means the first clinician-epidemiologist eye on health care delivery, on many to suggest that randomized controlled A. L Cochrane well-respected and broadly applied trials were an appropriate means of interventions, and on whole fields of deciding questions regarding the effi- were appropriate for laboratory studies medicine and their underlying belief ciency and benefit oftreatment, I can and probably some animal and behav- systems (1). -
The Cochrane Collaboration: an Introduction P
toolbox research are unlikely to have a high ticular research questions. This is why become dated and irrelevant. Because of number of clinically based trials direct the evidence-based supplement will also this we will seek to both review our core ed towards them. Equally journals endeavour to include these when appro list regularly and also look beyond this which publish qualitative research are priate and well conducted. list. If any reader feels any particular disadvantaged in a table based on ran It is equally important that only well article is important and should be domised-controlled trials or systematic conducted and reported randomised included please feel free to contact the review. However rating journals on the controlled trials or systematic reviews editorial office with the reference. We basis of their number of citations is are included. If we were to look in detail will then include it in our review equally open to challenge as noted at both the randomised-controlled tri process. Provided it passes the quality above. als and systematic reviews identified by filters it will appear in the supplement. Well-conducted randomised -con- the search strategy above many would trolled trials and systematic reviews not meet our quality criteria (see page Acknowledgements based on them have great potential for 32). This supplement will endeavour to To Christine Allot, Librarian, at the Berkshire Health Authority who conducted the answering questions about whether a include only good quality articles relat medline searches. treatment does more harm than good ing to treatment, diagnostic testing, particularly in the clinical situation. -
Global Public Health: Ecological Foundations Online
4LViI (Free download) Global Public Health: Ecological Foundations Online [4LViI.ebook] Global Public Health: Ecological Foundations Pdf Free Franklin White, Lorann Stallones, John M. Last audiobook | *ebooks | Download PDF | ePub | DOC Download Now Free Download Here Download eBook #191270 in eBooks 2013-01-21 2013-01-21File Name: B00HNSNB8U | File size: 71.Mb Franklin White, Lorann Stallones, John M. Last : Global Public Health: Ecological Foundations before purchasing it in order to gage whether or not it would be worth my time, and all praised Global Public Health: Ecological Foundations: 0 of 0 people found the following review helpful. Five StarsBy S BGood quality. Little highlights.0 of 0 people found the following review helpful. InformativeBy R. E. Tanniehill-KingVery informative book. Love the case studies.0 of 0 people found the following review helpful. Five StarsBy WADICurrent issues in ecology from theory to practice are extensively explored in this valuable reference. Amid ongoing shifts in the world economic and political order, the promise for future public health is tenuous. Will today's economic systems sustain tomorrow's health? Will future generations inherit fair access to health and health care?An important hope for the health of future generations is the establishment of a well-grounded, global public health system. Global Public Health: Ecological Foundations addresses both the challenges and cooperative solutions of contemporary public health, within a framework of social justice, environmental sustainability, -
King's Research Portal
King’s Research Portal DOI: 10.1016/S0140-6736(17)30276-3 Document Version Peer reviewed version Link to publication record in King's Research Portal Citation for published version (APA): Hurwitz, B. (2017). What Archie Cochrane learnt from a single case. Lancet, 389(10069), 594-595. https://doi.org/10.1016/S0140-6736(17)30276-3 Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rights Copyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights. •Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research. •You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policy If you believe that this document breaches copyright please contact [email protected] providing details, and we will remove access to the work immediately and investigate your claim. -
Evidence-Based Medicine and Archie Cochrane
Profiles in Medical Courage: Evidence-Based Medicine and Archie Cochrane “Medicine is a science of uncertainty and an art of probability.” -Sir William Osler Abstract Archibald (Archie) Cochrane is often credited with being the inspiration for evidence- based medicine. His influential 1971 book, “Effectiveness and Efficiency”, strongly criticized the lack of reliable evidence behind many common healthcare practices. His call for a collection of systematic reviews led to the creation of The Cochrane Collaboration, named in honor of him. Archie Cochrane's life was a tortuous one, which included psychoanalysis, service in two wars, and studies of pneumoconiosis, tuberculosis and healthcare delivery. In this profile of medical courage we explore not only his thoughts on healthcare but his extraordinary background that shaped his ideas. Early Life Archie Cochrane was born in 1909 in Galashiels, Scotland, a cloth manufacturing town 30 miles south of Edinburgh. His family was wealthy mill owners that instilled in Archie the principles of self-reliance and accomplishment. This was important since his father died in the First World War when Archie was 8. However, Archie was financially secure since as the first born, he inherited a private income. By all accounts, he was a bright student. After attending preparatory school at Rhos-on- Sea in Wales, Archie won a scholarship to Uppingham School in Rutland, England, where he became a school prefect and a member of the rugby team. In 1927, he won a scholarship to King’s College Cambridge, where he graduated in 1930 with honors in natural sciences. His inheritance enabled him to continue studying, and during 1931 he worked on tissue culture at the Strangeways Laboratory at Cambridge and later in Toronto. -
And Pneumonia: Risk Factors for Pneumonia in Children Under 5 Years Revisited Zafar Fatmi Aga Khan University, [email protected]
eCommons@AKU Community Health Sciences Department of Community Health Sciences December 2002 A comparison of 'cough and cold' and pneumonia: risk factors for pneumonia in children under 5 years revisited Zafar Fatmi Aga Khan University, [email protected] Franklin White Aga Khan University Follow this and additional works at: https://ecommons.aku.edu/pakistan_fhs_mc_chs_chs Recommended Citation Fatmi, Z., White, F. (2002). A comparison of 'cough and cold' and pneumonia: risk factors for pneumonia in children under 5 years revisited. International Journal of Infectious Diseases, 6(4), 294-301. Available at: https://ecommons.aku.edu/pakistan_fhs_mc_chs_chs/387 Original Report A comparison of ‘cough and cold’ and pneumonia: risk factors for pneumonia in children under 5 years revisited Zafar Fatmi(i) and Franklin White(i) Objectives: The aim of this study was to identify and measure the risk factors differentiating upper respiratory infection from pneumonia. Methods: The World Health Organization’s acute respiratory infection case management criteria were used. We studied 259 cases of pneumonia (cases) and 187 cases of ‘cough and cold’ (controls) among children under 5 years of age at a large tertiary-care hospital in Gilgit, Pakistan. While previous studies used healthy controls, in this study we used controls who had mild infection (‘cough and cold’). Results: In the multivariate logistic regression analysis, lack of immunization (adjusted odds ratio (AOR)= 1.54,95% CI 1.0,2.3), previous history of pneumonia (AOR=1.77,95% CI 1.16,2.7), younger age (AOR for each preceding month in children aged up to 59 months=l.Ol, 95% CI 0.99,1.03) and malnutrition (wasting) (AOR=2.2,95% CI 1.0,5.23) were revealed as important risk factors for pneumonia. -
Reliable and Accessible Reviews of the Evidence for the Effect of Health
Reliable and accessible JENNIFER EVANS Recent developments aim to improve the reviews of the evidence translation of research into clinical for the effect of health practice care: the role of the Cochrane Collaboration and the CONSORT statement The aim of clinical research is to improve glaucoma, the second most important cause of patient care. If it is to do so, the main providers blindness worldwide, for which considerable of health care along with purchasers and variation in treatment exists. Review of trials of patients need to be informed about the results of the treatment of glaucoma has shown that research. The medical literature is huge and appropriate research to guide clinical practice most people rely on reviews of the literature. In has not been done.s the past, reviews were seen as secondary to The Cochrane Collaboration has evolved to clinical research and less important than the meet the challenge set out by Archie Cochrane. primary research on which they were based. It is an international network of individuals This meant that little attention was paid to the 'committed to prepare and maintain systematic quality of the reviews and scientific principles reviews of randomised controlled trials of the were often ignored in their preparation. At the effects of health care, and of other evidence end of the 1970s, Archie Cochrane, a British when appropriate, and to make this information epidemiologist, wrote that 'It is surely a great readily available to decision-makers at all levels criticism of our profession that we have not of health care systems.' The Collaboration is organised a critical summary, by speciality or relatively young, its first formal meeting being subspeciality, adapted periodically, of all , in 1993, but has developed rapidly. -
Ben Goldacre
BUILDING EVIDENCE INTO EDUCATION BEN GOLDACRE MARCH 2013 PHOTO REDACTED DUE TO THIRD PARTY RIGHTS OR OTHER LEGAL ISSUES 2 Background Ben Goldacre is a doctor and academic who writes about problems in science and evidence based policy, with his Guardian column “Bad Science” for a decade, and the bestselling book of the same name. He is currently a Research Fellow in Epidemiology at London School of Hygiene and Tropical Medicine. To find out more about randomised trials, and evidence based practice, you may like to read “Test, Learn, Adapt”, a Cabinet Office paper written by two civil servants and two academics, including Ben Goldacre: https://www.gov.uk/government/publications/test-learn-adapt-developing- public-policy-with-randomised-controlled-trials 3 4 Table of contents Background 3 Building evidence into education 7 How randomised trials work 8 Myths about randomised trials 10 Making evidence part of everyday life 15 5 6 Building evidence into education I think there is a huge prize waiting to be claimed by teachers. By collecting better evidence about what works best, and establishing a culture where this evidence is used as a matter of routine, we can improve outcomes for children, and increase professional independence. This is not an unusual idea. Medicine has leapt forward with evidence based practice, because it’s only by conducting “randomised trials” - fair tests, comparing one treatment against another - that we’ve been able to find out what works best. Outcomes for patients have improved as a result, through thousands of tiny steps forward. But these gains haven’t been won simply by doing a few individual trials, on a few single topics, in a few hospitals here and there. -
Exploring the Impact of Providing Evidence-Based Medicine Training to Service Users Andy Gibson1, Kate Boddy2*, Kath Maguire2 and Nicky Britten2
Gibson et al. Research Involvement and Engagement (2015) 1:10 DOI 10.1186/s40900-015-0010-y RESEARCH ARTICLE Open Access Exploring the impact of providing evidence-based medicine training to service users Andy Gibson1, Kate Boddy2*, Kath Maguire2 and Nicky Britten2 * Correspondence: [email protected] Plain English summary 2NIHR CLAHRC South West Peninsula (PenCLAHRC), University Within health services research in the UK, there has been growing interest in of Exeter, Veysey Building, Salmon Pool Lane, Exeter EX2 4SG, UK evidence-based medicine (EBM) and patient and public involvement (PPI) in Full list of author information is research. These two movements have a common goal of improving the quality available at the end of the article and transparency of clinical decision making. So far, there has been relatively little discussion about how these two movements might relate to each other, despite their common concern. Indeed, some in the PPI movement have expressed doubts about the implications of EBM for PPI because they worry that its emphasis on evidence from clinical trials marginalises the importance of a patient’s individual experiences in clinical decision making. The purpose of this paper is to examine the potential for EBM and PPI to complement one another. We analysed the feedback of 10 members of the Peninsula Public Involvement Group (PenPIG) who attended EBM workshops. These workshops trained people in the basics of EBM and were primarily attended by health professionals. We used thematic analysis, a qualitative data analysis method, to explore the responses. We found that participation in the workshops appears to have increased the ability and confidence of members of the public to actively participate as both producers and consumers of research evidence. -
Kilpatrick, Stewart: Transcript of an Audio Interview (23-May-2000)
History of Modern Biomedicine Research Group School of History, Queen Mary University of London Mile End Road, London E1 4NS website: www.histmodbiomed.org AUDIO INTERVIEW TRANSCRIPT Kilpatrick, Stewart: transcript of an audio interview (23-May-2000) Interviewer: Andy Ness Transcriber: Jaqui Carter Editors: Tilli Tansey, Hugh Thomas Date of publication: 03-Feb-2017 Date of interview: 23-May-2000 Publisher: Queen Mary University of London Collection: History of Modern Biomedicine Interviews (Digital Collection) Reference: e2017049 Number of pages: 15 DOI: 10.17636/01019163 Acknowledgments: The History of Modern Biomedicine Research Group is funded by the Wellcome Trust, which is a registered charity (no. 210183). The interview was funded by a Wellcome Trust (grant 059533; 1999- 2001; awarded to Professor George Davey-Smith, Dr A R Ness and Dr E M Tansey) and its publication by a Wellcome Trust Strategic Award entitled “Makers of modern biomedicine: testimonies and legacy” (2012-2017; awarded to Professor Tilli Tansey). Citation: Ness A R (intvr); Tansey E M, Thomas H (eds) (2017) Kilpatrick, Stewart: transcript of an audio interview (23- May-2000). History of Modern Biomedicine Interviews (Digital Collection), item e2017049. London: Queen Mary University of London. Note: Audio interviews are conducted following standard oral history methodology, and received ethical approval from UCL (2000) and QMUL (reference QMREC 0642). Related material has been deposited in the Wellcome Library. © The Trustee of the Wellcome Trust, London, 2017 History of Modern Biomedicine Interviews (Digital Collection) - Kilpatrick, S e2017049 | 2 Kilpatrick, Stewart: transcript of an audio interview (23-May-2000)* Biography: Professor Stewart Kilpatrick OBE FRCP (1925-2013) was Registrar at the Pneumoconiosis Research Unit in South Wales from 1952 to 1955. -
The Cochrane Lecture the Best and the Enemy of the Good
6 6Journal of Epidemiology and Community Health 1994;48:6-15 The Cochrane lecture J Epidemiol Community Health: first published as 10.1136/jech.48.1.6 on 1 February 1994. Downloaded from The best and the enemy of the good: randomised controlled trials, uncertainty, and assessing the role of patient choice in medical decision making Klim McPherson Abstract clear today as it did then. Nowadays, both the This lecture aimed to create a bridge to problem and solution are very familiar to us span the conceptual and ideological gap all. The problem was that much of the health between randomised controlled trials care provided was unevaluated, and therefore and systematic observational compari- possibly of no benefit, and the solution - sons and to reduce unwanted and unpro- randomised controlled trials - were the only ductive polarisation. The argument, secure way of knowing the truth of the matter. simply put, is that since randomisation Cochrane's essential idea was that the reli- alone eliminates the selection effect of able assessment of effectiveness was the only therapeutic decision making, anything key to scientific health care, but such methods short of randomisation to attribute cause as he advocated had been disparaged by the to consequent outcome is a waste of time. medical establishment - paradoxically because If observational comparison does have they seemed to be less scientific than the more any significant part in evaluating medi- traditional basic methods of scientific evalu- cal outcomes, there is a grave danger of ation. A problem of methodological imperia- "the best", to paraphrase Voltaire, lism which is with us still, but in different becoming "the enemy of the good". -
Update on Cholera Epidemic by Country Erika Harding
University of New Mexico UNM Digital Repository NotiSur Latin America Digital Beat (LADB) 2-26-1992 Update On Cholera Epidemic By Country Erika Harding Follow this and additional works at: https://digitalrepository.unm.edu/notisur Recommended Citation Harding, Erika. "Update On Cholera Epidemic By Country." (1992). https://digitalrepository.unm.edu/notisur/8605 This Article is brought to you for free and open access by the Latin America Digital Beat (LADB) at UNM Digital Repository. It has been accepted for inclusion in NotiSur by an authorized administrator of UNM Digital Repository. For more information, please contact [email protected]. LADB Article Id: 062482 ISSN: 1060-4189 Update On Cholera Epidemic By Country by Erika Harding Category/Department: General Published: Wednesday, February 26, 1992 ARGENTINA. Feb. 13: Health Minister Julio Cesar Araoz told reporters that "the cholera outbreak is not yet under control." The minister said another 18 cases of the disease had been confirmed, bringing the total to 181. The cholera death toll as of Feb. 13 was 11. Feb. 14: A Buenos Aires-Lima- Los Angeles flight arrived in the US with five passengers suffering from cholera. One passenger died. Argentine officials claimed the victims were infected by food brought on board in Peru. Peruvian authorities denied the claim. [Aerolineas Argentinas management decided to suspend stops in Lima until identification of the origin of cholera contamination affecting passengers on the flight path. By Feb. 22, 65 passengers had been diagnosed with cholera. In response to claims by Aerolineas Argentinas that Peru was the source of cholera contamination, on Feb. 23 the Peruvian government suspended the airline's permit to operate in Peru.] Feb.