ATAC Trial Steering Committee Membership Maroondah, VIC, Australia; Associate G Richardson, S Hart: Monash (Writing Committee denoted by *) Medical Centre, Melbourne, VIC, Australia; Associate G Toner, *M Baum (Chairman and Principal Investigator for the main ATAC P Francis: Peter MacCallum Cancer Institute, Melbourne, VIC, Australia; trial), University College , London, UK; AR Bianco, Universita R Snyder, I Burns: St Vincents Hospital, Melbourne, VIC, Australia; Degli Studi Di Napoli Federico II, Napoli ; *AU Buzdar, The M Friedlander, D Goldstein: Prince of Wales Hospital, Randwick, University of Texas, M.D. Anderson Cancer Centre, Houston, USA; NSW, Australia; J Forbes, D Jackson: Newcastle Mater Hospital, M Coibion, Institut Bordet, Brussels, Belgium; *J Cuzick (Independent Waratah, NSW, Australia. statistician), Cancer Research UK, London, UK; M Dowsett, The Royal Belgium—A Makar, D Van den Weyngaert: AZ Middelheim, Antwerpen, Marsden Hospital, London, UK; WD George, Western Infirmary, Belgium; D Gangji, T Velu: Hôpital Erasme, Brussels, Belgium; Glasgow, UK; J Gray, Belfast City Hospital, Belfast, UK; *J Houghton, M Coibion, J-M Nogaret: Institut Bordet, Brussels, Belgium; P Neven, N Williams, Cancer Research UK and UCL Cancer Trials Centre, UCL Laurent: St Jan Ziekenhuis, Brussels, Belgium; J De Mol, F Van Aelst: , London, UK; A Howell, Christie Hospital and Holt Heilig Hart Ziekenhuis, Roeselare, Belgium. Radium Institute, Manchester, UK; *T Sahmoud, R Hellmund, Canada—SR Sehdev: Suite 102, 157 Queen Street East, Brampton, AstraZeneca Pharmaceuticals, Wilmington, USA; Ms L Thornton, Ontario, Canada; R Simard: Complexe Hospitalier de la Sagami, AstraZeneca Pharmaceuticals, , UK; JS Tobias, The Chicoutimi, Quebec, Canada; JR MacKey (J-M Nabholtz former PI): Meyerstein Institute of Clinical Oncology, , Cross Cancer Institute, Edmonton, Alberta, Canada; J Dufresne: CUSE London, UK. (Fleurmont), Fleurmont, Quebec, Canada; WS Lofters: Kingston Regional Cancer Center, Kingston, Ontario, Canada; Holland: Lethbridge Cancer International Coordinating Committee Clinic, Lethbridge, Alberta, Canada; HL Solow: Markham Stouville AR Bianco, Universita degli Studi Di Napoli Federico II, Napoli, Italy; Health Centre, Markham, Ontario, Canada; JA Gapski: Trillium Health AU Buzdar, The University of Texas, MD Anderson Center, Houston, Centre, Mississauga, Ontario, Canada; SH Rubin (OR Keller former PI): TX, USA; M Coibion, Institut Bordet, Brussels, Belgium; M Constenla, South East Health Care Oncology Department, Moncton, New Hospital Montecelo, Pontevedra, ; W Distler, Frauenklinik Carl Brunswick, Canada; A Robidoux: CHUM Campus Hotel ñ Dieu, Gustav Carus Universitaet Dresden, Germany * J Forbes, Newcastle Montreal, Quebec, Canada; B Lesperance: Hospital Sacre Coeur, Mater Misericordiae Hospital, NSW, Australia; A Howell, Christie Montreal, Quebec, Canada; LC Panasci: McGill Department of Oncology, Hospital, Manchester, UK; WD George, Western Infirmary, Glasgow, Montreal, Quebec, Canada; LA Zibdawi: York County Hospital, UK; JP Guastalla, Centre Leon Berard, Lyon, France; * JGM Klijn, Newmarket, Ontario, Canada; J Chang: Lakeridge Health, Oshawa, Daniel den Hoed Cancer Centre and Erasmus University Medical Centre, Ontario, Canada; ML Brigden (D L Saltman former PI): Penticton Rotterdam, The Netherlands; GY Locker, Evanston Hospital, Kellogg Regional Hospital, Penticton, British Columbia, Canada; Cancer Care Center, Evanston IL, USA; RE Mansel, University of Wales RF Wierzbicki: Peterborough Regional Health Center Oncology Clinic, College of Medicine, Cardiff, UK; JM Nabholtz, University of California Peterborough, Ontario, Canada; BP Findlay: Hotel Dieu Hospital at Los Angeles, Los Angeles, CA, USA; T Nagykalnai, Uzsoki U Oncology Department, Quebec City, Quebec, Canada; J Robert: CHA Hospital, Budapest, Hungary; A Nicolucci, GIVIO Co-ordinating Centre, Pavillion St Sacrement, Quebec City, Quebec, Canada; S Lebel Consorzio Mario Negri Sud, Centro di Ricerche Farmacologiche e (M Potvin former PI): Hospital Laval, Quebec City, Quebec, Canada; Biomediche, S. Maria Imbaro, Italy; U Nylen, Radiumhemmet, MRBT Tirona: Allan Blair Cancer Center, Regina, Saskatchewan, Karolinska sjukhuset, Stockholm, Sweden; T Sahmoud, AstraZeneca Canada; MJ Burnell: Atlantic Health Sciences Corp, Saint John, New Pharmaceuticals, Wilmington, USA; R Sainsbury, Huddersfield Royal Brunswick, Canada; OR Keller (B A Walley former PI), Saskatoon Cancer Infirmary, Huddersfield, UK. Center, University of Saskatoon, Saskatoon, Saskatchewan, Canada; PLD Walde: Group Health Centre, Sault Ste Marie, Ontario, Canada; S-C Tang: H Bliss Murphy Cancer Centre, St Johns, Newfoundland, International Project Team Canada; CJ Germond: Northeastern Ontario Regional Can, Sudbury, E Foster, SCTN Central Office, Information and Statistics Division, Ontario, Canada; Y Rahim: Toronto East General Hospital, Toronto, Edinburgh, UK; Nicola Griffiths, AstraZeneca Pharmaceuticals, Ontario, Canada; JJ Wilson: Humber River Regional Hospital, Weston, Macclesfield, UK; J Houghton, N Williams, Cancer Research UK and Ontario, Canada; AL Cooke (D M Bowman former PI): Manitoba Cancer UCL Cancer Trials Centre, UCL Medical School, London, UK; Treatment and Research Foundation, Winnipeg, Manitoba, Canada. A Nicolucci, Consorzio Mario Negri Sud, S. Maria Imbaro, Italy; S Czech Republic—K Petrakova, R Demlova: Masarykuv onkologicky ustav, Pollard, Northern Yorkshire Clinical Trials Research Unit, Leeds, UK; Brno, Czech Republic; P Vodvarka, T Kysela: FNsP Ostrava, Ostrava T Sahmoud, AstraZeneca Pharmaceuticals, Wilmington, USA; Poruba, Czech Republic; B Konopasek, P Mares: Vseobecna fakultni nemocnice, Praha, Czech Republic. Independent Data Monitoring Committee France—J-Edouard Mention: Centre de Gyneco-Obst, CHU, Amiens, M Buyse, International Institute for Drug Development (ID squared), France; D Serin, Y Goubely-Brewer: Clinique Ste Catherine, Avignon, Brussels, Belgium; R Margolese, Mc Gill University, The Sir Mortimer France; J-P Labat, J-P Malhaire: CHU Brest, Brest, France; G Devulder, B Davis Jewish General Hospital, Montreal, Quebec, Canada; JMA S Mirdat-Dako: Centre Hospitalier Laënnec, Creil, France; D Houze De Northover, ICRF Colorectal cancer unit, St Mark's Hospital, Harrow, L’Aunoit, J-Y Charvolin: Hôpital St Philibert, Lomme, France; Middlesex, UK. J-P Guastalla, T Bachelot: Centre Léon Bérard, Lyon, France; R Coquard, B Velay: Clinique St Jean, Lyon, France; C Lejeune, D Hadjadj-Aoul: Hôpital de la Conception, Marseille, France; Collaborative/Operational Groups M Untereiner, O Rixe: Hôpital-Clinique Claude Bernard, Metz, France; JF Forbes (Group Co-ordinator), JK Wakeham (Study Co-ordinator): F Laffargue, Hôpital Arnaud de Villeneuve, Montpellier, France; M Rios: Australian New Zealand Breast Cancer Trials Group Operations Office; Centre Alexis Vautrin, Nancy, France; J-M Vannetzel, R Mahjoubi: S de Placido (Study Co-ordinator), C Carlomagno (Study Co-ordinator), Centre Chirurgical Henri Hartmann, Neuilly sur Seine, France; Universita degli Studi Di Napoli Federico II, Italy; A Nicolucci (Group R Samak: Cabinet Medical, Nice, France; F Morvan, F Rousseau: Co-ordinator), M Belfiglio (Study Co-ordinator), M Valentini (Study Centre Hospitalier, Pontoise, France; C Veyret, JP Julien: Centre Henri Co-ordinator): GIVIO Group, Consorzio Mario Negri Sud, Italy; Becquerel, Rouen, France; B Cutuli, P Quetin: Centre Paul Strauss, L Foster (Trial Co-ordinator): Scottish Cancer Therapy Network Strasbourg, France; J-P Brettes, C Mathelin: HÙpital Civil, Strasbourg, (SCTN), Information & Statistics Division, Edinburgh, Scotland; France. M Tyrer (Trial monitor), R Catterick (Trial monitor): North West Breast Germany—W Distler, A Schindelhauer: Frauenklinik Carl Gustav Carus Group, Burnley, Lancashire, UK; S Pollard (Trial Co-ordinator): Universitaet Dresden, Germany; W Jaeger, G Wieland: Frauenklinik Northern & Yorkshire Clinical Trials Research Unit (NYCTRU), Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Germany; University of Leeds, Leeds, UK; J Houghton (Senior Lecturer in Clinical C Oberhoff, D Hanisch: Zentrum f. Frauenheilkunde Trials), N Williams (Trial Co-ordinator): Cancer Research UK & UCL Universitaetsklinikum Essen, Germany; J Bechler, S Malur: Klink f. Cancer Trials Centre, London, UK. Frauenheilkunde u. Geburtshilfe FriedrichñSchiller Universitaet Jena, Germany; W Eiermann, G Raab: Frauenklinik vom Roten Kreuz, Principal and main co-investigators in the ATAC trial Muenchen, Germany. Argentina—F Coppola, C Bas: Hospital Aleman, Capital Federal, Buenos Hungary—C Polgar: National Oncology Institute, Budapest, Hungary; Aires, Argentina; J Itala, G Cortese: Hospital de Clinicas, Buenos Aires K Moskovits, Z Nagy: St Imre Hospital, Budapest, Hungary; University, Capital Federal, Buenos Aires, Argentina; A Nuñez de Pierro, T Nagykalnai, L Landherr: Uzsoki st. Hospital, Budapest, Hungary; D Allemand: Hospital Gral de Agudos-Juan Fernandez, Capital Federal, T Pinter, G Herodek: Petz Aladar Hospital, Gyor, Hungary; B Piko, Buenos Aires, Argentina; R Orti, R Testa: Hospital Italiano, Capital I Szegedi: Pandy Kalman County Hospital, Gyula, Hungary; J Szanto, Federal, Buenos Aires, Argentina; J Lebron, University of Buenos Aires, L Marazi: BAZ County Hospital, Miskolc, Hungary; Z Kahan: SZTE Capital Federal, Buenos Aires, Argentina Oncotherapy Clinic, Szeged, Hungary. Australia—G Gill, J Kollias: Royal Hopsital, Adelaide, SA, Ireland—E McDermott, N O’Higgins: St Vincent’s Hospital, Dublin 4, Australia; J Chirgwin, M Leyden: Box Hill Hospital, Box Hill, VIC, Ireland; T Gorey: The Mater Hospital, Dublin 7, Ireland; F Given, Australia; J Beith, A Sullivan: Royal Prince Albert Hospital, S Tormey: University College Galway, Galway, Ireland. Camperdown, NSW, Australia; S Della-Fiorentina, A Goldrick: Liverpool Italy—M Bonsignori, S Rossini, Ospedale Torrette, Ancona, Italy; Hospital, Liverpool, NSW, Australia; J Chirgwin, Maroondah Hospital, F Di Vito, M Cucchi: Ospedale Regionale, Aosta, Italy; F Testore,

THE LANCET • Vol 359 • June 22, 2002 • http://image.thelancet.com/extras/02art5373appendix.pdf 1

For personal use. Only reproduce with permission from The Lancet Publishing Group. ARTICLES

L Giaretto: Ospedale Civile, Asti, Italy; F Recchia, S De Filippis: Karolinska sjukhuset, Stockholm, Sweden; T Fornander, G Winblad: Ospedale Civile, Avezzano, Italy; M De Lena, F Schittulli: Istituto Södersjukhuset, Stockholm, Sweden; R Fernstad, L Löfgren: St Görans Scientifico Oncologico, Bari, Italy; A Martoni, E Piana: Ospedale S sjukhus, Stockholm, Sweden; T Ambré, M Nilsson: Centrallasarettet, Orsola-M Malpighi, Bologna, Italy; G Marini, P Marpicati: Spedali Civili, Växjö, Sweden. Brescia, Italy; M Pintus, A Tedde: Ospedale Oncologico A Businco, The Netherlands—L Siegenbeek van Heukelom: Medisch Centrum Cagliari, Italy; M Botta, D Degiovanni: Ospedale S Spirito, Casale Alkmaar, Alkmaar, The Netherlands; R Boom, D van Geldere: Monferrato, Italy; L Basilico, M Taraborrelli: Ospedale SS Annunziata, Ziekenhuis Amstelveen, Amstelveen, The Netherlands; A de Boer: Chieti, Italy; S Bravi, F Biagioni: Ospedale Civile, Città di Castello, Italy; IJsselland Ziekenhuis, Capelle a/d IJssel, The Netherlands; E Maartense: M Giordano, G Luchena: Ospedale S Anna, Como, Italy; Reinier de Graaf Gasthuis, Delft, The Netherlands; D Halkema: Albert G Scognamiglio, A Beretta: Ospedale Valduce, Como, Italy; P Marchetti, Schweitzer Ziekenhuis, Dordrecht, The Netherlands; C Dijkhuis: ME D’Addario: Università degli Studi, Coppito (L’Aquila), Italy; Oosterschelde Ziekenhuis, Goes, The Netherlands; M van Hennik: M Obialero, F Peradotto: Ospedale Civile, Cuorgné, Italy; Beatrix Ziekenhuis, Gorinchem, The Netherlands; P Willemse: M Indelli, G Lelli: Arcispedale S Anna, Ferrara, Italy; A Nuzzo, Academisch Ziekenhuis Groningen, Groningen, The Netherlands; L Laudadio: Ospedale Floraspe Renzetti, Lanciano, Italy; M D’Aprile, H van Veelen, H de Graaf: Medisch Centrum Leeuwarden, Leeuwarden, M Natali: Ospedale S Maria Goretti, Latina, Italy; G Cruciani, The Netherlands; E Bruggink, L Strobbe: Nijmeegs Interconfessioneel E Montanari: Ospedale Umberto I, Lugo, Italy; E Aitini, G Cavazzini: Ziekenhuis Canisius Wilhelmina, Nijmegen, The Netherlands; Ospedale C Poma, Mantova, Italy; V Adamo, G Altavilla: Policlinico D de Gooyer: Ziekenhuis Franciscus, Roosendaal, The Netherlands; Universitario “G Martino”, Messina, Italy; S Barni, A Ardizzoia: J Janssen: Ziekenhuis Franciscus, Roosendaal, The Netherlands; M Leijs: Ospedale S Gerardo, Monza (Milan), Italy; A De Matteis, G Landi: Medisch Centrum Rijnmond Zuid, loc. Clara, Rotterdam, The Istituto Nazionale Studi e Cura Tumori ìG Pascaleî, Napoli, Italy; Netherlands; J Stouthard: Medisch Centrum Rijnmond Zuid, loc. Clara, G D’Aiuto, R Thomas Istituto Nazionale Tumori “G Pascale”, Napoli, Rotterdam, The Netherlands; J Klijn, C Seynaeve: Academisch Italy; R Lauria, M De Laurentis: Universita Federico II, Napoli, Italy; Ziekenhuis Rotterdam, loc. Daniel den Hoed, Rotterdam, A Fornasiero, H Koussis: Ospedale Civile, Padova, Italy; G Brignone, The Netherlands; F Erdkamp: Maasland Ziekenhuis, Sittard, L Mesi: Ospedale Oncologico M Ascoli, Palermo, Italy; A Riccardi, The Netherlands; F Kauw: Albert Schweitzer Ziekenhuis, Sliedrecht, P Pugliese: Policlinico S Matteo, Pavia, Italy; G Pavia, T Porro: Ospedale The Netherlands; A van Reisen: Ziekenhuis Zeeuws Vlaanderen, loc. Civile, Rho, Italy; F Cognetti, P Papaldo: Istituto Regina Elena, Roma, de Honte, Terneuzen, The Netherlands; C van der Heul: St Elisabeth Italy; G Gasparini, MA Castellana: Ospedale S Filippo Neri, Roma, Italy; Ziekenhuis, Tilburg, The Netherlands; J Ruit: Vlietland Ziekenhuis, M Mattarei, S Robbiati: Ospedale Civile S Maria delle Grazie, Rovereto, Vlaardingen, The Netherlands; L Kerhofs: Ziekenhuis Walcheren, Italy; A Farris, G Sanna: Istituto Clinical Medica, Sassari, Italy; Vlissingen, The Netherlands; R de Kan, R Hellingman: Zweedse Rode C Vucusa, M Viglietta: Ospedale SS Annunziata, Savigliano, Italy; Kruis Ziekenhuis, Zierikzee, The Netherlands; E Trommel: Albert G Fornari, A Turletti: Ospedale Evangelico Valdese, Torino, Italy; Schweitzer Ziekenhuis, Zwijndrecht, The Netherlands; J Coenen: Isala E Arnoldi: AO Bolognini H S Isidoro, Trescore Balneario, Italy; Klinieken, loc. Sophia, Zwolle, The Netherlands. A Richetti, M Molteni: AO Ospedale di Circolo e Fondazione Macchi, Turkey—E Baltali: Hacettepe University Oncology Hospital, Ankara, Varese, Italy. Turkey; A Aydiner: Istanbul University Oncology Institute, Istanbul, New Zealand—I Campbell, R Gannaway: Breast Care Centre, Waikato Turkey. Hospital, Hamilton, New Zealand. UK—A Hutcheon, T Sarkar: Aberdeen Royal Infirmary, Aberdeen, UK; Poland—J Tujakowski, M Osmanska: Regional Oncology Centre, T Bates, N Griffiths: South Kent Hospitals NHS Trust, William Harvey Bydoszcz, Poland; P Koralewski, M Urbanska: Ludwick Rydygier Hospital, Ashford, UK; M Carr: Cheviot & NHS Trust, Memorial Hospital, Krakow, Poland; B Karczmarek-Borowska, Wansbeck General Hospital, Ashington, UK; C Alcock: Stoke Mandeville B Kukielka-Budny: Regional Oncology Centre, Lublin, Poland; Hospital NHS Trust, Aylesbury, UK; B Lavery, E Sugden: Horton M Teresiak, P Laski: Regional Oncology Centre, Pozan, Poland; Hospital Radcliffe Hospitals NHS Trust, Banbury, UK; N Stuart, Derek M Krzakowski, E Pucula: Maria Sklodowska-Curie Memorial Oncology Crawford: Gwynedd Hospital NHS Trust, Bangor, UK; A Wilkinson, Centre, Warszawa, Poland. G Odling-Smee: Belfast City Hospital NHS Trust, Belfast, UK; —A Alcazar: Hospital Reynaldo dos Santos, Vila Franca de Xira, W Abram, A Patterson: Belfast City Hospital NHS Trust, Belfast, UK; Portugal; O Campos, I Botto: Maternidade Bissaya Barreto, Coimbra, A Aukland, D Spooner: Sandwell Healthcare NHS Trust, Sandwell Portugal; O Candeias, H Ramires: Hospital de Sao Joao, Porto, Portugal; District General Hospital, Birmingham, UK; H Bishop, R Salem: The M Chumbo: Hospital Condes de Castro Guimaraes, Cascais, Portugal; Royal Bolton Hospital, Bolton, UK T Hickish, A Skene: Royal H Gervasio: IPO - Hospital de Dia, Coimbra, Portugal; D Jardim da Bournemouth & Christchurch NHS Trust, Royal Bournemouth Hospital, Pena, R NabiÁo: Hospital de S Marcos, Braga, Portugal; C Oliveira, Bournemouth, UK; C Bradley, Dennis Parker: Bradford Royal Infirmary, E Abraul: Hospitais da Universidade de Coimbra, Coimbra, Portugal. Bradford, UK; S Cawthorn, M Shere: Frenchay Healthcare NHS Trust, Slovak Republic—S Spanik, I Vochyanova: Onkologicky ustav sv. Alzbety, Frenchay Hospital, Bristol, UK; S Goodman, E Whipp: United Bristol Bratislava, Slovak Republic; M Wagnerova, I Andrasina: FNsP L Healthcare NHS Trust, Bristol Royal Infirmary, Bristol, UK; A Moody: Pasteura, Kosice, Slovak Republic. West Suffolk Hospital NHS Trust, Bury St Edmunds, UK; C Wilson, South Africa—A Maxwell: 140 Chelmsford Road, Berea, South Africa; E Cox: Addenbrookesís NHS Trust Hospital, Cambridge, UK; R Mansel, L Goedhals, L Smith: Nationale Hospital, Bloemfontein, South Africa; H Sweetland: University Hospital of Wales NHS Trust, Cardiff, UK; I Werner, E Murray: Groote Schuur Hospital, Cape Town, South Africa; P Sauven, S Chandrasekharan: Mid Essex Hospital Services NHS Trust, J Apffelstaedt, I Loubser: Tyerberg Hospital, Cape Town, South Africa; Chelmsford and Essex Centre, Chelmsford, UK; G Layer: St Peters D Hacking, Durban Oncology Centre, Westridge, Durban, South Africa; Hospital NHS Trust, Chertsey, UK; P Murray, F MacNeill: Essex Rivers G Landers: Parklands Hospital, Durban, South Africa; D Vorobiof: Healthcare NHS Trust, Essex County Hospital, Colchester, UK; J Fox: Sandton Oncology Centre, Sandton, Johannesburg, South Africa. Castle Hill Hospital, Cottingham, UK; A Ball: Crawley Horsham NHS Spain—A Barnadas: Hosp. Germans Trias i Pujol, Badalona (Barcelona), Trust, Crawley Hospital, Crawley, UK; G Rawsthorne: Mid- Spain; C Alonso Muñoz: Hosp. Sta. Cruz y San Pablo, Barcelona, Spain; Hospitals NHS Trust, Leighton Hospital, Crewe, UK; R Blunt: Dudley J Baselga, J Tabernero: H. Vall D’Hebron, Barcelona, Spain; M Beltrán, Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, UK; E Canals: H. Josep Trueta, Gerona, Spain; S Menjón, Hosp. Virgen de J Dewar, A Thompson: Ninewells Hospital & Medical School, Dundee, las Nieves, Granada, Spain; L Calvo: Hosp. Juan Canalejo, La Coruña, UK; W Taylor, A Cook: North Durham NHS Tryst, Dryburn Hospital, Spain; JR Mel, G Quintero: Hosp. Xeral Calde, Lugo, Spain; G Perez Durham, UK; I Kunkler: Western General Hospital, Edinburgh, UK; Manga, A Alonso: Hosp. Gregorio Marañón, Madrid, Spain; P España, D Cameron, R Leonard: Western General Hospital, Edinburgh, UK; R Cubedo Cervera: Hosp. Puerta de Hierro, Madrid, Spain; C Sánchez W Cunliffe, D Browell: Gateshead Hospitals NHS Trust, Queen Martínez, M Repolles Escarda: Hosp. Ramón y Cajal, Madrid, Spain; Elizabeth Hospital, Gateshead, UK; WD George, AN Harnett, P Aramburo, JE Alés, H. Ruber Internacional, Madrid, Spain; JJ Valerdi, CT Twelves: Western Infirmary, Glasgow, UK; DC Smith: Victoria M Tejedor Gutierrez: Hosp. de Navarra, Pamplona, Spain; M Constenla, Infirmary, Glasgow, UK; M Kissin: The Royal Surrey County and St R Garcia Arroyo: Hosp. De Montecelo, Pontevedra, Spain; Lukes NHS Trust, Royal Surrey County Hospital, Guildford, UK; J Lizon, C Angeles: H. San Juan, San Juan (Alicante), Spain; JM Lopez- V Modgill, P Surtees: Halifax Royal Infirmary, Halifax, UK; R Knox, Vega: H. Marques de Valdecilla, Santander, Spain; D Menedez, Harrogate District Hospital, Harrogate, UK; J Joffe: Huddersfield Royal H. Provincial de Conxo, Santiago de Compostela, Spain; JA Moreno Infirmary, Huddersfield, UK; B Lavery, A Harris: Oxford Radcliffe Nogueira, P Borrego: Hosp. Virgen del Rocio, Sevilla, Spain; J Montalar, Hospital NHS Trust, John Radcliffe Hospital, Headington, UK; J A Santaballa: Hosp. La Fe, Valencia, Spain; V Guillem, A Llombart: Nicholls, S Raymond: St Albans & Hemel Hempstead NHS Trust, UK; Instituto Valenciano OncologÌa, Valencia, Spain; G Huidobro Vence, B Lavery, N Rowell: NHS Trust, Wycombe General J Casal: Hosp. Meixoeiro, Vigo, Spain. Hospital, High Wycombe, UK; J LeVay, T Archer: Ipswich Hospitals Sweden—S-Å Olsson, L Ryden: Sjukhuset, Ängelholm, Sweden; NHS Trust, Ipswich, UK; A Nejim, I Hutchinson: Airedale General S Rotstein, D Pettersson-Sköld: Danderyds sjukhus, Stockholm, Sweden; Hospital, Keighley, UK; M Lansdown, T Perren: St Jamesís University B Börjesson: Länssjukhuset, Halmstad, Sweden; P-E Jönsson, Hospital, Leeds, UK; K Horgan, D Dodwell: Leeds General Infirmary, M Malmberg: Helsingborg Hospital, Helsingborg, Sweden; L Lovén, Leeds, UK; C Holcombe: Royal Liverpool University Hospital NHS I Grybäck: Centralsjukhuset, Kristianstad, Sweden; C Ingvar, Trust, Royal Liverpool Hospital, Liverpool, UK; J Rainey: St Johns P Lindblom: University Hospital, Lund, Sweden; S B Holmberg: Hospital, Howden, Livingston, UK; G Howard: Western General SU/Mölndal Hospital, Mölndal, Sweden; U Nylén, E Lidbrink: Hospital, Edinburgh, UK S Holt, Y Sharaiha: Llanelli & Dinefwr NHS

2 THE LANCET • Vol 359 • June 22, 2002 • http://image.thelancet.com/extras/02art5373appendix.pdf

For personal use. Only reproduce with permission from The Lancet Publishing Group. ARTICLES

Trust, Price Phillip Hospital, Llanelli, UK; J Tobias, M Gaze: UCL University of South Carolina School of Medicine, Columbia, SC, USA; Hospitals NHS Trust, The Middlesex Hospital, London, UK; J Mansi, LR Laufman: Columbus CCOP, Columbus, OH, USA; JL Blum: US N Sacks: St Georges NHS Trust Hospital, Tooting, London, UK; Oncology Services, Dallas, TX, USA; H S Shaw (L N Harris former PI): C Coulter, S Stewart: St Marys NHS Trust Hospital, London, UK; Duke University Medical Center, Trent Drive, Durham, NC, USA; A Jones, T Davidson: Royal Free Hampstead NHS Trust, The Royal Free N Dimitrov (D MacDonald former PI): Michigan State University, East Hospital, London, UK; JRC Sainsbury: University College London, Lansing, MI, USA; E T OíBrien: The Regional Cancer Center, Erie, PA, London, UK; A Jones, A Wilson: NHS Trust, USA; GY Locker: Evanston Northwestern Health Care, Kellogg Cancer London, UK; I Smith, G Gui: The Royal Marsden Hospital NHS Trust, Care Center, Evanston, IL, USA; NJ Robert: Inova/Fairfax Hospital, Falls The Royal Marsden Hospital, London, UK; D Matheson: Macclesfield Church, VA, USA; MS Rubin: Florida Cancer Specialists, Fort Myers, District General Hospital, Macclesfield, UK; A Howell, A Stewart: FL, USA; GR Justice: Pacific Coast Hematology/Oncology Medical Christie Hospital, Manchester, UK; L Barr, N Bundred: Withington Group, Fountain Valley, CA, USA; TJ O’Rourke (JR Borst former PI): Hospital, Manchester, UK; P Durning, A Clason: Grand Rapids Clinical Oncology Program, Grand Rapids, MI, USA; AU Hospital, Middlesborough, UK; A Mitchell, R Souter: Milton Keynes Buzdar: MD Anderson Cancer Center, Houston, TX, USA; JK Hon: General Hospital, Milton Keynes, UK; C Griffith, A Griffiths: Newcastle Comprehensive Cancer Care Institute, Huntsville, AL, USA; RH Clark: Hospitals NHS Trust, Royal Victoria Infirmary, Newcastle-upon-Tyne, Hematology/Oncology Associates, Jackson, MI, USA; HB Sher: UK; C Gaffney: Glan Hafren NHS Trust, Royal Gwent Hospital, Jacksonville Oncology Group, Jacksonville, FL, USA; K B Pendergrass: Newport, UK; M Stokes, Daisy Hill Hospital, Newry, UK; J Dawson, Kansas City Internal Medicine, Kansas City, MO, USA; AM Grossman: S Powis: Northampton General Hospital NHS Trust, Northampton, UK; Knoxville Hematology/Oncology, Knoxville, TN, USA; HP DeGreen: I Goulbourne: North Tyneside Health Care NHS Trust, North Tyneside Lancaster Cancer Center Ltd, Lancaster, PA, USA; R Kosierowski: North General Hospital, North Shields, UK; A Makris, E Maher: Mount Penn Hospital, Lansdale, PA, USA; HJ Allen: Southwest Cancer Clinic, Vernon & Watford Hospitals NHS Trust, Mount Vernon Hospital, Las Vegas, NV, USA; JD Conroy: (M A Simmonds former PI), Central Northwood, UK; JR Robertson, R Blamey: Nottingham City Hospital PA Hematology Medical Oncology Associate, Lemoyne, PA, USA; NHS Trust, Nottingham, UK; R Nangalia, H Bishop: George Eliot JJ Sternberg: Clinical Investigation Specialist, Suite 300, Searcy Building, Hospital NHS Trust, Nuneaton, UK; I McIntosh: Royal Oldham Little Rock, AR, USA; GP Sarna: Ceders-Sinai Comprehensive Cancer Hospital, Oldham, UK; D Pinto, Sperrin Lakelands: Health & Social Center, Los Angeles, CA, USA; L Bhupalam (G C Michelson former PI): Care Trust, Tyrone County Hospital, Omagh, UK; B Lavery, A Jones: James Graham Brown Cancer Center, University of Louisville, Louisville, Oxford Radcliffe Hospital NHS Trust, The Churchill Hospital, Oxford, KY, USA; MH Ward: Medical Arts Clinic Suite 100, Lubbock, TX, UK; R Watkins, S Prance: Plymouth Hospital NHS Trust, Derriford USA; PT Silberstein: North Iowa Mercy Health Center, Mason City, IA, Hospital, Plymouth, UK; C Tyrrell, P Macleod: Plymouth Hospital NHS USA; PV Pickens: Abington Hematology-Oncology, Meadowbrook, PA, Trust, Derriford Hospital, Plymouth, UK; C Yiangou, P Perry: USA; MA Schwartz: Comprehensive Cancer Center, Miami Beach, FL, Portsmouth Hospital NHS Trust, Portsmouth, UK; C Humphrey: Birch USA; J Singson: Oncology Associates SC, Milwaukee, WI, USA; Hill Hospital, Rochdale, UK; M Quigley: Havering Hospitals NHS Trust, JG Schneider: Winthorp University Hospital Oncology/Hematology Oldchurch Hospital, Romford, UK; Z Saad, E Hoare: Salford Royal Division, Mineola, NY, USA; MM Oken: Virginia Piper Cancer Institute, Hospitals NHS Trust, Hope Hospital, Salford, UK; R Coleman, Minneapolis, MN, USA; MW Meshad: Providence Hospital, Mobile, AL, S Kohlhardt: Weston Park Hospital, Sheffield, UK; B Harrison: Northern USA; FA Greco: Sarah Cannon Cancer Center, Nashville, TN, USA; General Hospital, Sheffield, UK; R Agrawal: Royal Shrewsbury NHS MJ Guarino: Christiana Hospital, Newark, DE, USA; KK Boatman: Trust, Shrewsbury, UK; P Forouhi: Ealing Hospital NHS Trust, Ealing INTERGIS Oncology Services, Oklahoma City, OK, USA; JA Mailliard: Hospital, Southall, UK; P Canney: Stirling Royal Infirmary, Stirling, UK; Creighton Cancer Center, Omaha, NE, USA; AS Kelley: Ventura County P : Stepping Hill Hospital, Stockport, UK; C Hennessy, A Peel: Hematology-Oncology, Oxnard, CA, USA; DW Northfelt (E S Camacho North Tees General Hospital, Stockton-on-Tees, UK; E Hoare: Trafford former PI): Desert Hospital Comprehensive Cancer Center, Palm General Hospital, Trafford, UK; S Kelly, K Stepp: Royal Springs, CA, USA; RA Hirsch: Comprehensive Cancer Research Group, Hospitals NHS Trust, Treliske Hospital, Truro, UK; D Sebag- Pembroke Pines, FL, USA; BR Piccone: The Care Group PC, Montefiore: Pinderfield Hospital, Wakefield, UK; R Grieve, , PA, USA; MS Roberts: Hematology & Oncology Associates T Waterworth: Walsgrave Hospitals NHS Trust, Walsgrave, UK; Ltd, Phoenix, AZ, USA; JI Spector: Berkshire Hematology Oncology, G Copeland: Hospital NHS Trust, Warrington, UK; D Jones: Pittsfield, MA, USA; N Tirumali (A G Glass former PI): South Warwickshire General Hospitals NHS Trust, Warwick, UK; Hematology/Oncology Kaiser Permanente, Central Interstate Medical A Robinson, C Trask: Southend Healthcare NHS Trust Hospital, Office, Portland, OR, USA; MA Deutsch: Raleigh Hematology Oncology, Westcliffe-on-Sea, UK; P Barrett-Lee: Velindre NHS Trust Hospital, Raleigh, NC, USA; DM Sahasrabudhe: University of Rochester Cancer Whitchurch, UK; R Rainsbury, V Hall: Royal Hampshire County Center, Rochester, NY, USA; P Bushunow (M Brower former PI): Hospital, Winchester & Eastleigh Healthcare NHS Trust, Winchester, Rochester General Hospital, Rochester, NY, USA; TJ Woodlock UK; D Berstock, R Errington: Wirral Hospital NHS Trust, Wirral, UK; (K J Pandya former PI): St Maryís Hospital, Rochester, NY, USA; D Fairlamb: Royal Wolverhampton Hospitals NHS Trust, New Cross WR Edwards: The Cancer Center, Rockford Clinic, Rockford, IL, USA; Hospital, Wolverhampton, UK; A Salman, A Johri: Worthing Southlands IA Jaiyesimi: Cancer Care Associates PC, Royal Oak, MI, USA; Hospital NHS Trust, Worthing Hospital, Worthing, UK; S Goodman, F C Kass: Santa Barbara Hematology-Oncology Medical Group, Santa G Sparrow: East Somerset NHS Trust, Yeovil District Hospital, Yeovil, Barbara, CA, USA; LW Keiser: Redwood Regional Medical Group, UK; S Nicholson: York District Hospital, York, UK. Santa Rosa, CA, USA; GV Burton: Louisiana State University Medical USA—A Mangalik: University of New Mexico Cancer Research and Center, Shreveport, LA, USA; JC Michalak: Siouxland Hematology/ Treatment Center, Albuquerque, NM, USA; SJ Yee: Suite 304, Arcadia, Oncology Associate, Sioux City, IA, USA; MS McHale: University CA, USA; JM Feigert: Arlington Fairfax Hematology/Oncology, Oncology Clinic, Sioux Falls, SD, USA; JR Goodman: Arlington, VA, USA; R O Kerr: Southwest Regional Cancer Center, Providence Hospital, Southfield, MI, USA; PD Byeff: Austin, TX, USA; K Tkaczuk: University of Maryland Cancer Center, Hematology/Oncology, Southington, CT, USA; KL Hoelzer: Springfield , MD, USA; M Thant: Hematology/Oncology Associates, Clinic, Springfield, IL, USA; EP Lester: Oncology Care Associates Baltimore, MD, USA; CE Hartz: Eastern Maine Medical Center, Cancer PLLC, St Joseph, MI, USA; AP Lyss: Missouri Baptist Cancer Center, Care of Maine, Bangor, ME, USA; GP Miletello: Hematology/Oncology St Louis, MO, USA; ME Woodson: Hematology Oncology Consultants Clinic, Baton Rouge, LA, USA; WJ Popovic: Illinois Oncology Ltd, Inc, St Louis, MO, USA; HS Puc: Hematology and Oncology Associates, Belleville, IL, USA; D B Myers: Billings Interhospital Oncology Project, Syracuse, NY, USA; F Senecal: Hematology Oncology Northwest PC, Billings, MT, USA; Thomas: Mid Dakota Clinic, Bismarck, ND, USA; Tacoma, WA, USA; J Horton: Moffitt Cancer Center & Research, AJ Koletsky: Comprehensive Cancer Center, Boca Raton, FL, USA; Tampa, FL, USA; RR Young: Scott & White Memorial Hospital, EG Levine: Roswell Park Cancer Institute, Buffalo, NY, USA; CF White: Temple, TX, USA; IS Lowenthal: Northwestern Connecticut Oncology Lahey Clinic, Department of Medical Oncology, Burlington, MA, USA; and Hematology Associates, Torrington, CT, USA; HB Nevinny: G Grana: Cooper University Hospital, Camden, NJ, USA; K E Weeman: Cancer Treatment Center of Tulsa, Tulsa, OK, USA; E P Gelman Aultman Hospital Cancer Research, Canton, OH, USA; LL Schlabach: (D F Hayes former PI) (M J C Ellis former PI): Georgetown University University Oncology Associates, Chattanooga, TN, USA; SG Taylor, Medical Lombardi Cancer Center, Washington, DC, USA; MA Illinois Masonic Cancer Center, , IL, USA; P Silverman: Vukelich: Kettle Moraine Oncology SC, West Bend, WI, USA; K University Hospitals of Cleveland, Cleveland, OH, USA; DL Headley: Seetharaman (L L Stolbach former PI): St Vincentís Hospital, The Oncology Clinic PC, Colorado Springs, CO, USA; M F Gonzalez: Worcester, MA, USA.

THE LANCET • Vol 359 • June 22, 2002 • http://image.thelancet.com/extras/02art5373appendix.pdf 3

For personal use. Only reproduce with permission from The Lancet Publishing Group.