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A Review on Self-Emulsified Drug Delivery System

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A Review on Self-Emulsified Drug Delivery System View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by ZENODO PHARMACEUTICAL AND BIOLOGICAL EVALUATIONS April 2016; vol. 3 (Issue 2): 140-153. www.onlinepbe.com ISSN 2394-0859 Review Article A review on self-emulsified drug delivery system Priya Thakare*, Vrushali Mogal, Pankaj Borase, Jaydeep Dusane, Sanjay Kshirsagar Department of Pharmaceutics, MET’s Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik 422003, Maharashtra, India *For correspondence ABSTRACT Miss. Priya Thakare, Post Graduate Student, Improving oral bioavailability of low poorly water soluble drugs using Department of Pharmaceutics, self-emulsifying drug delivery systems (SEDDS) possess significant MET’s Institute of Pharmacy, potential. Oral bioavailability of hydrophobic drugs can be improved Bhujbal Knowledge City, using SEDDS, and appears most promising. Their dispersion in gastro Adgaon, Nashik 422003, intestinal (GI) fluid after administration forms micro or nano emulsified Maharashtra, India. drug which gets easily absorbed through lymphatic pathways bypassing Email: priyathakare15 the hepatic first pass metabolism. Parameters like surfactant concentration, @gmail.com oil to surfactant ratio, polarity of emulsion, droplet size and charge on droplet plays a critical role in oral absorption of drug from SEDDS. For hydrophobic drug substances that exhibit dissolution step as rate limiting for absorption, SEDDS offer an improvement in rate and extent of absorption and gives more reproducible plasma concentration time profiles. Use of combined in vitro dispersion and digestion methodologies has enabled a much improved understanding of role of intestinal lipid processing on solubilization behavior of lipid based drug delivery systems (LBDDS). The article gives a brief view on the solid lipid nanoparticles and its evaluation. Received: 06 March 2016 Keywords: Self-Emulsifying formulation, Lipid-based drug delivery systems, Accepted: 28 March 2016 Characterization, Bioavailability enhancement Introduction necessary for self-emulsification (SEDDS) typically produce emulsion with a droplet size Self emulsifying drug delivery system (SEDDS) between 100 and 300 nm while SMEDDS form is defined as isotropic mixture of oil and transparent micro emulsion with a droplet size of surfactants or alternatively one or more less than 50 nm. When compared with hydrophilic solvents and co-solvents. Upon mild emulsions which are sensitive and metastable agitation followed by dilution in aqueous media dispersed forms, SEDDS and SMEDDS are such as the gastrointestinal (GI) fluid, these physically stable formulations that are easy to systems can form fine oil in water (o/w) manufacture. SMEDDS can be formulated to emulsions or micro emulsions. Self micro give sustained release dosage form by adding emulsifying formulations spread readily in the polymeric matrix, which is not ionizable at GI tract and the digestive motility of the physiological pH and after ingestion in contact stomach and the intestine provide the agitation with GI fluid forms a gelled polymer making it possible to release the micro emulsified active ©Pharmaceutical and Biological Evaluations 140 Thakare P. et al. Pharmaceutical and Biological Evaluations 2016; vol. 3 (2): 140-153. agent in a continuous and sustained matter by formulations to improve the oral bioavailability diffusion. Bases of self micro emulsifying of poorly soluble drugs .In fact, the most popular system have been formulated using medium approach is the incorporation of the drug chain triglyceride oils and non-ionic surfactant compound into inert lipid vehicles such as oils, which are acceptable for oral ingestion. The surfactant dispersions, self-emulsifying lipophilic (poorly water soluble) drugs such as formulations, emulsions and liposomes with nifedipine, griseofulvin, cyclosporine, digoxin, particular emphasis on self-emulsifying drug itrconazole, carbamazepine, piroxicam, steroids, delivery systems (SEDDS). ibuprofen, diazepam, etc. are formulated in SMEDDS to improve efficacy and safety. It Novelty statement should be noted that water-in-oil version of SMEDDS has also been investigated. This This review on Self Emulsifying Drug Delivery system can be liquid but also semisolid Systems (SEDDS) is written as these drug depending on the excipient’s choice. These are delivery systems have unparalleled prospect in traditionally designed for the oral route. These enhancing bioavailability of low soluble drugs preparations can be given as soft or hard gelatin of biopharmaceutical classification. An capsules for easy administration and precise extensive and updated description of literature dosage. reports on different types of self emulsifying formulations, techniques employed, The better absorbed drugs across the characterization, optimization and application gastrointestinal tract (GIT) provide good oral strategies are discussed comprehensively to bioavailability but have number of potentially direct the formulation scientists in formulating a limiting factors. These include appropriate stable, safe and effective self emulsifying stability and solubility in the GI fluid, formulation. The figures are self designed to reasonable intestinal permeability, and resistance prove the concept, mechanism and meaning of to metabolism both within the enterocyte and the SEDDS. liver.1 It has realized that the oral bioavailability of poorly water soluble, lipophilic drugs may be Self-emulsifying drug delivery enhanced when coadministered with a meal rich systems (SEDDS) in fat this has led to increase recent interest in the formulation of poorly soluble drugs in lipids SEDDS belong to lipid-based formulations. as a means to enhance drug solubilisation in the 2-7 Lipid formulations can be oils, surfactant GIT. Lipid-based formulations not only dispersions, emulsions, solid lipid nanoparticles improve but normalize drug absorption, which is and liposomes. SEDDS are isotropic mixtures of particularly beneficial for low therapeutic index 8-10 drug, lipids and surfactants, usually with one or drugs. These formulations can also enhance more hydrophilic co-solvents or co-emulsifiers. drug absorption by a number of ancillary Upon mild agitation followed by dilution with mechanisms, e.g. (a) including inhibition of P- aqueous media, these systems can form fine (oil glycoprotein-mediated drug efflux and pre in water) emulsion instantaneously. ‘SEDDS’ is absorptive metabolism by gut membrane-bound a broad term, typically producing emulsions cytochrome enzymes (b) promotion of lymphatic with a droplet size ranging from a few transport, which delivers drug directly to the nanometers to several-microns. “Self micro- systemic circulation while avoiding hepatic first- emulsifying drug delivery systems” (SMEDDS) pass metabolism and (c) by increasing GI 11-15 indicates the formulations forming transparent membrane permeability. Modification of the microemulsions with oil droplets ranging physicochemical properties, such as salt between 100 and 250 nm. “Self-nano- formation and particle size reduction of the emulsifying drug delivery systems” (SNEDDS) compound may be one approach to improve the 16,17 is a recent term with the globule size ranges less dissolution rate of the drugs. However, these than 100 nm.18 A schematic about self-micro- methods have their own limitations. In recent emulsifying drug delivery systems” (SMEDDS) years much attention has focused on lipid−based is shown in Figure 1. ©Pharmaceutical and Biological Evaluations 141 Thakare P. et al. Pharmaceutical and Biological Evaluations 2016; vol. 3 (2): 140-153. Need of SEDDS Oral delivery of poorly water-soluble compounds is to pre-dissolve the compound in a suitable solvent and fill the formulation into capsules. The main benefit of this approach is that predissolving the compound overcomes the initial rate limiting step of particulate dissolution in the aqueous environment within the GI tract. However, a potential problem is that the drug may precipitate out of solution when the formulation disperses in the GI tract, particularly if a hydrophilic solvent is used (e.g. polyethylene glycol). If the drug can be Figure 1: Illustration of what is SEDDS. dissolved in a lipid vehicle there is less potential for precipitation on dilution in the GI tract, as partitioning kinetics will favor the drug It has been suggested that self-emulsifying drug remaining in the lipid droplets. Another strategy delivery systems can be prepared which, after for poorly soluble drugs is to formulate in a solid oral administration in gelatin capsules, will solution using a water-soluble polymer to aid emulsify within the gastric contents.19 solubility of the drug compound. For example, Advantage of self-emulsifying formulations over polyvinyl pyrrolidone (PVP) and polyethylene solid dosage formulations is the avoidance of glycol (PEG 6000) have been used for preparing slow drug dissolution. Distribution of the solid solutions with poorly soluble drugs. One emulsion within the GIT helps to avoid the potential problem with this type of formulation irritancy. Some marketed self emulsified dosage is that the drug may favor a more forms are described in Table 1. thermodynamically stable state, which can result Table 1: Marketed self emulsified dosage in the compound crystallizing in the polymer forms. matrix. Therefore the physical stability of such formulations needs to be assessed using Drug Compou Dosage Company techniques such as differential scanning name nd form calorimetry or
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