Medication Alternatives for the Elderly 5/30/08 The following table details the drugs to avoid and the recommended agents to be considered as alternatives.*

Drug Class Drugs to Avoid Concerns Formulary Alternatives Antianxiety meprobamate Highly addictive and sedating anxiolytic Buspirone

Can cause extrapyramidal adverse ® Antiemetic trimethobenzamide effects. Low effectiveness as an dolasetron (Anzemet ), ondansetron, antiemetic metoclopramide† amitriptyline Depending on condition treated Due to strong anticholinergic and sedative chlordiazepoxide-amitriptyline alternatives include: citalopram, perphenazine-amitriptyline properties, amitriptyline and doxepin are ® Antidepressant rarely the antidepressant of choice in the escitalopram (Lexapro ), paroxetine, doxepin elderly sertraline, lidocaine, mirtazapine, trazodone Long-term use of full dose has the indomethacin Analgesic/Non- potential of producing GI bleeding, renal Short acting NSAIDS, COX-II for short- narcotic/NSAIDs ketorolac failure, high blood pressure, and heart term use naproxen failure chlorpheniramine cyproheptadine Potent anticholinergic properties can dexchlorpheniramine cause sedation, weakness, blood ® Antihistamines fexofenadine, azelastine (Astelin ) diphenhydramine pressure changes, dry mouth, and urinary hydroxyzine retention promethazine mesoridazine (Serentil®) olanzapine (Zyprexa®), quetiapine Greater potential for CNS and ® ® Antipsychotics, typical (Seroquel ), risperidone (Risperdal ), extrapyramidal adverse effects ® thioridazine pimozide (Orap ), trifluoperazine

amphetamine mixtures No preferred agents exist within the dextroamphetamine Potential for dependence, angina, drug class. Perform risk-benefit Amphetamines hypertension, and myocardial infarction dexmethylphenidate determination prior to use. methamphetamine chlordiazepoxide Benzodiazepines are typically excluded Long half-life in elderly patients, producing chlordiazepoxide/amitriptyline from Medicare Part D benefits. Short- Long-acting prolonged sedation and increasing the risk and intermediate-acting are preferred if benzodiazepines diazepam of falls and fractures flurazepam a benzodiazepine is required.

Nifedipine Potential for hypotension. Adverse effect Nifedipine- long-acting (Adalat CC® Calcium channel blockers ® ® – short-acting only avoided by use of long-acting Afeditab CR, Procardia XL ) belladonna alkaloids No preferred agents exist within the drug class. Perform risk-benefit clidinium-chlordiazepoxide GI antispasmodic drugs are highly determination prior to use. Lower doses Gastrointestinal anticholinergic and have uncertain dicyclomine should be used and patients should be antispasmodics effectiveness hyoscyamine monitored due to the increased propantheline potential for adverse effects. H2 antagonist cimetidine CNS adverse effects including confusion famotidine, nizatidine, ranitidine carisoprodol chlorzoxazone Most muscle relaxants are poorly tolerated cyclobenzaprine by elderly patients by causing Skeletal muscle relaxants ® baclofen, tizanidine metaxalone (Skelaxin ) anticholinergic adverse effects, sedation, methocarbamol and weakness orphenadrine No cardioprotective effect. Significant risk No preferred agents exist within the Oral estrogen (Premarin, Ogen, of carcinogenic effects (breast and drug class. Perform risk-benefit Oral Estrogen Menest) endometrial cancer) determination prior to use. Has a prolonged half-life in elderly patients and could cause prolonged hypoglycemia. Oral hypoglycemics chlorpropamide It is the only oral hypoglycemic that can glipizide cause syndrome of inappropriate antidiuretic hormone secretion More CNS adverse events than other pentazocine narcotic analgesics including hallucinations and confusion. hydrocodone, morphine, oxycodone, Narcotics propoxyphene and combination Offers few analgesic advantages over fentanyl transdermal patch products acetaminophen, while adverse effects are similar to other narcotic drugs.

Drug Class Drugs to Avoid Concerns Formulary Alternatives dipyridamole Vasodilators May cause orthostatic hypotension hydralazine, minoxidil

nitrofurantoin (Macrodantin) May cause renal impairment Methenamine mandelate, trimethoprim Other methyltestosterone (Android, Potential for prostatic hypertrophy and Danazol Virilon, Testred) cardiac problems Disease or Condition Drugs to Avoid Concerns Formulary Alternatives Reassess need for medication and Sedative hypnotics, tricyclic Adverse events such as cognitive eliminate or reduce dose. Mirtazapine Falls antidepressants, and impairment sedation and confusion, or trazodone for insomnia, or selective antipsychotics increases risk of falls. serotonin reuptake inhibitors for depression. Tricyclic antidepressants and Depending on condition treated sedating antihistamines, Anticholinergic medications are strongly alternatives include: nonsedating antispasmodics, associated with causing drug-induced antihistamines (fexofenadine, Cognitive Impairment antivertigo/antiemetic, skeletal delirium. The elderly adults with dementia azelastine), selective serotonin muscle relaxants, and are more likely to develop drug-induced reuptake inhibitors, dopamine agonists, antiparkinson (benztropine, cognitive impairment than healthy adults. mirtazapine, or trazodone. trihexyphenidyl) Acetaminophen, salsalate, lidocaine, The inhibition of renal prostaglandin low dose corticosteroids (inflammatory Chronic Renal Failure NSAIDS and COX-II inhibitors production could lead to acute and chronic conditions) hydrocodone, morphine, nephrotoxic effects. oxycodone, fentanyl/transdermal.

*The Guide is being provided to you by Highmark Inc. as a courtesy and is based on information from the following sources: 1. Beers MH. Explicit criteria for determining potentially inappropriate medication use by the elderly: an update. Arch Intern Med. 1997; 157: 1531-6 2. HEDIS® 2007

The Guide was prepared by Highmark Inc. and Quality Insights of Pennsylvania, the Medicare Quality Improvement Organization for Pennsylvania, under contract with the Centers for Medicare & Medicaid Services (CMS), an agency of the U.S. Department of Health and Human Services. The contents presented do not necessarily reflect CMS policy. The list of medications may not be current or definitive and is not intended to be complete or exhaustive.

The medications listed may not apply to all patients or all clinical situations. Medications have different effects on different people. The information presented is not intended to override clinicians’ judgment. Neither Highmark Inc. nor Quality Insights of Pennsylvania shall be liable for any adverse effects or consequences resulting from the use or misuse of any medication listed in the Guide.”

Distribution of the Guide does not constitute an endorsement or recommendation of any medication listed.