Department of Microbiology School of Basic Medical Sciences University of Madras

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

1 Name of the Department Microbiology 2 Year of establishment 1976 3 Is the Department part of a University School/Faculty of the university? 4 Names of programmes offered (UG, PG, M.Sc., Medical Microbiology M.Phil., Ph.D., Integrated Masters; (Faculty of Medicine), MD Integrated Ph.D., D.Sc., D.Litt., etc.) Microbiology –upto 2012, & PhD 5 Interdisciplinary programmes and Endocrinology, Biochemistry, departments involved Anatomy, Physiology, Biostatistics, Pharmacology, Pathology 6 Courses in collaboration with other Nil universities, industries, foreign institutions, etc. 7 Details of programmes discontinued, if MD (Awaiting renewal of any, with reasons recognition from MCI) 8 Examination System: Annual/ Semester/ Semester (CBCS) Trimester/Choice Based Credit System 9 Participation of the department in the Elective & Core courses offered by other departments

10. Number of teaching posts sanctioned, filled and actual (Professors/Associate Professors/Asst. Professors/others) Sanctioned Filled Actual (including CAS & MPS) Professor 2 2 - Associate Professors - - - Asst. Professors 5 2 - Others - - -

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

11. Faculty profile with name, qualification, designation, area of specialization, experience and research under guidance

Major Area of PhD S.No Name & Qualification Designation specialization Students Dr.Thangam Menon, 1 Professor and Head Bacteriology/Mycology 10 Ph.D Dr.M.Elanchezhiyan, Immunology/Virology/ 2 Professor 2 Ph.D Microbiology Dr.Padma Krishnan, 3 Assistant Professor Bacteriology/Microbiology 8 Ph.D 4 Dr. Srivani Ramesh, Ph.D Assistant Professor Bacteriology/Microbiology 6

12 List of senior Visiting Fellows, adjunct faculty, · Dr. Pushkala (July emeritus professors 2011 to November 2011) · Dr. Jayam Ravi (March 2013 to August 2013) 13 Percentage of classes taken by temporary faculty – Nil programme-wise information 14 Programme-wise Student Teacher Ratio 1:10 15 Number of academic support staff (technical) and administrative staff: i) No of administrative staff sanctioned : Clerk-1 & OA-1 ii) No of administrative staff filled : Clerk-1 & OA-1 iii) No of technical staff sanctioned : Technicians-3 Nos. iv) No of technical staff filled : Technicians-2 Nos.

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

16. Research thrust areas as recognized by major funding agencies i) Antiviral drug development

ii) Immunomodulatory substance development iii) Molecular analysis of drug resistance mechanisms of human pathogens. iv) Infective endocarditis v) Streptococcal Infection vi) Candidiasis

17. Number of faculty with ongoing projects from a) national b) international funding agencies and c) Total grants received. Give the names of the funding agencies, project title and grants received project-wise. Grant Funding Ongoing Projects - Title Faculty Duration Received Agency in rupees Streptococcal invasive locus (sil) in invasive and Dr. Thangam Menon UGC 2011-2014 10,96,800/- non invasive strains of Streptococcus pyogenes. Molecular pathogenesis of Dr. Thangam Menon ICMR 2011-2013 30,49,010/- streptococcal endocarditis “Studies on mumps virus infections among MMR Dr. M. ICMR 2010 - vaccine recipients and 22,60,000 Elanchezhiyan Ad-hoc 2013 mumps associated infertility”

“Development of Dr. M. 2012 - diagnostic kits for Mtb UPE 5,00,000 Elanchezhiyan 2014 infections”

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

Molecular characterization and detection of high level aminoglycoside (Hlare) Dr. S. Srivani UGC and Glycopeptide 2013-2014 10,18,800/- Ramesh Major resistance (VRE) among clinical isolates of Enterococci.

Isolation and characterization of unusual Dr. S. Srivani TNSRC 2012-2013 6000/- bacterial agents from lower Ramesh respiratory tract infections.

TOTAL 79,30,610/-

Completed Projects: Microbiological study of diabetic foot ulcer –a Dr. S. Srivani FundingUGC 2008- Grant prospectiveProject Titlestudy from RameshFaculty Major Duration2011 10,22,800/- Agency Received Chennai Molecular characterization Dr. Thangam Isolation and characterization ICMR 2006- of Candida albicans from Menon 14,00,000/- of unusual bacterial agents Dr. S. Srivani 2009.2012 - HIV patients. TNSRC from lower respiratory tract Dr.Ramesh Thangam 2013 6000/- Emm gene sequencing on DBT 2006-2009 20,48,000/- S.pyogenesinfections. Menon MolecularMolecular Epidemiologycharacterization ofand Group detection A Streptococcal of high level Dr. Thangam UGC aminoglycosideinfections in school (Hlare) and MenonDr. S. Srivani UGC 2006-2009 6,88,800/- 2013-14 childrenGlycopeptide of Chennai resistance by Vir Ramesh Major 10,18,800/- typing (VRE) among clinical Studies on anti-HIV Ministry of isolates of Enterococci. Dr. M. properties of extract Earth 4,66,03,000/ Elanchezhiyan 2007-2012 derived from marine Sciences - organisms TOTAL 5,37,52,700/- Molecular Characterization and Dr. Padma UGC 2009 - Typing of Carbapenem 9,17,800/- Krishnan Major 2012 Resistant Non-Fermenting Gram Negative Bacilli Madras HLAR in multidrug Dr. S. Srivani university 2006-2007 resistant enterococci. Ramesh research 40,000/- starter fund

Current trends of Dr. S. Srivani TNSRC 2006-2007 4000/- susceptibility of linezolid Ramesh

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

and quinopristin and dalfopristin to MDR enterococci.

Incidence of Burkholderia pseudomallei and other Dr. S. Srivani TNSRC 2007-08 Burkholderia species in Ramesh 3500/- Chennai.

Microbiological study of diabetic foot ulcer –a Dr. S. Srivani UGC 2008-2011 prospective study from Ramesh Major 10,22,800/- Chennai

Isolation and characterization of Dr. S. Srivani unusual bacterial agents TNSRC 2012-2013 Ramesh 6000/- from lower respiratory tract infections.

Molecular characterization and detection of high level aminoglycoside (Hlare) Dr. S. Srivani UGC and Glycopeptide 2013-14 Ramesh Major 10,18,800/- resistance (VRE) among clinical isolates of Enterococci.

5,37,52,700/ TOTAL -

18. Inter-institutional collaborative projects and associated grants received a) National collaboration - b) International collaboration – Grant Duration Status of Received S.No Name of the project Funded by of the the (Amount project project in Rupees) ICMR- Molecular Pathogenesis of BMBF (Indo- 2011- 1 Streptococcal Endocarditis 30,49,010/- Ongoing German 2013

Project) Molecular and Phenotypic ICMR – 2009 - 2. 42,55,678/- Completed characterization of BMBF 2012

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

virulence and resistant (Indo – determinants in hospital German and community acquired Project) isolates of Staphylococcus aureus from Chennai, South India

19. Departmental projects funded by DST-FIST; UGC-SAP/CAS, DPE; DBT, ICSSR, AICTE, etc.; total grants received. · Ongoing Projects : Total grant Rs.79,30,610/- · Completed Projects: Total grant Rs. 5,37,52,700/- Details furnished in Item No.17 20. Research facility / centre with · state recognition- Antimicrobial susceptibility testing, antimicrobial · national recognition - Antimicrobial susceptibility testing, antimicrobial · international recognition -: Molecular diagnosis of infectious diseases

21. Special research laboratories sponsored by / created by industry or corporate bodies - Nil 22. Publications: Total number of publications (2007 - 2013): Dr. Thangam Menon National- 13 International – 25 Citation Index – 1 to 28 Impact Factor – 0.521 to 6.169 Dr. M. Elanchezhiyan National: 7 International: 8 Citation Index – 0 to 1 Impact Factor – 0 to 4.590 Dr. Padma Krishnan National - 18 International – 19

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

Citation Index – range / average – 1 to 953 Impact Factor – range / average - 0.11 to 16.14 Chapters in Books – 1 Dr. Srivani Ramesh National - 3 International – 8 Citation Index – range / average – 2 to 3 Impact Factor – range / average - 0.47 to 3.067 Edited Books -- Proceedings of International Symposium on Changing Etiology of Emerging Infectious Diseases on 6th February 2013 (CEEID 2013) Books with ISBN with details of publishers - Nil Number listed in International Database (For e.g. Web of Science, Scopus, Humanities International Complete, Dare Database - International Social Sciences Directory, EBSCO host, etc.) --

23. Details of patents and income generated -

24. Areas of consultancy and income generated - i)) Dr. Thangam Menon – Area: Microbiology, Frontier Lifeline ii) Dr. Elanchezhiyan – Himalaya Pharma Project: Rs. 3 lakhs

iii) Dr. Padma Krishnan Consultancy Projects

Project Title Funding Agency Amount Received Evaluation of Co-amoxiclav against Streptococcus Ranbaxy INR pneumoniae and Haemophilus influenzae from pediatric Laboratories 1,40,000 cases of otitis media, tonsillitis, sinusitis, pneumonia and Private Limited bronchitis Evaluation of quinolones, third generation cepholosporins Nicholas Piramal INR and traditional antibiotics against salmonella strains India Limited 80,000 causing enteric fever, an invitro study Bacteria challenge Test for performance evaluation of Membrane Hitec, INR Capillary Multi bore Hollow fibre Ultrafilter membrane Team House 13,000 Preparation of Chloramphenicol sensitivity disc for Piramal INR Paraxin Chloramphenicol in-vitro study Healthcare 12,000 Evaluation of efficacy of Cefditoren versus other drugs in Ranbaxy INR pathogens isolated from patients with lower respiratory Laboratories 70,000 tract infections (LRI) Private Limited Comparative antibacterial activity of cefpodoxime/ Piramal INR cefpodoxime – clavulanic acid against aerobic bacterial Healthcare 1,20,000

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology pathogens: An in-vitro study Limited Student consultancy project UICIC INR 4,05,000 Income generated: 20% of amount received as University consultancy charges iv) Dr. Srivani Ramseh: - Areas of consultancy: Infectious disease diagnosis and molecular analysis of drug resistance mechanisms of human pathogens. - Income generated: Rs.4,35,0000/- Through UICIC Students Training

25. Faculty selected nationally / internationally to visit other laboratories / institutions / industries in India and abroad Yes, India and abroad (USA, Germany)

26. Faculty serving in a) National committees b) International committees c) Editorial Boards d) any other (please specify): Yes - National Committee & Editorial Board

Dr. Thangam Menon 1) University Grants Commission – SAP review committee member 2) IBSC member –Frontier Lifeline Hospitals (as DBT nominee) 3) DST – Member of Technology Development Board 4) Government of India Central Drugs Standard Control Organization (DGHS)- Expert member 5) ICMR - Member of Instituitional Human Ethical Committee

Dr. Elanchezhiyan 1) Associate Editor in International Journal of Medical and Pharmaceutical Virology.

27. Faculty recharging strategies (UGC, ASC, Refresher / orientation programs, workshops, training programs and similar programs). Faculty recharging Faculty name Year Organized by program attended

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

UGC Refresher Course Academic Staff College, Dr. Padma Krishnan on Life Sciences 2013 University of Madras Bathch XI Academic Staff College, Dr.S.Srivani Ramesh Orientation Programs 2008 University of Madras UGC Refresher Course Academic Staff College, Dr.S.Srivani Ramesh 2011 on life science University of Madras

28. Student projects

· percentage of students who have done in-house projects including inter- departmental projects – 100% · percentage of students doing projects in collaboration with other universities / industry / institute – 30% 29. Awards / recognitions received at the national and international level by

Name of the Faculty Awards Dr. Thangam Menon 1) Siri Research Award (1992) – Indian Prof & Head Association of Biomedical Scientists (IABMS) 2) Agathiar Award (1999) - Indian Association of Biomedical Scientists (IABMS) 3) TANSA Award (2006) – Tamil Nadu Council for Science and Technology 4) ICMR Sr Scientist Award (2008) - Indian Council of Medical Research 5) D.Sc., (2013) – University of Madras Dr. Padma Krishnan 1. Fellow of the Association of

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

Assistant Professor Biomedical Scientists (FABMS) Title (2005) – Indian Association of Biomedical Scientists (IABMS)

2. Best poster presentation award in the 26th Annual Conf of IABMS (2006) - Indian Association of Biomedical Scientists (IABMS)

3. Best Teacher Award (2012) - Lion's Club International

30. Seminars/ Conferences/Workshops organized and the source of funding (national / international) with details of outstanding participants, if any. (Details furnished in Appendix II) i) One day International Seminar on “New Insights in the Management of Antibiotic Resistance” (NISMAR, 2009) - Funded by UOM, TNSST ii) National Symposium on “Recent Trends in Opportunistic Mycotic Infections” (RTOMI, February 2011) -Funded by University of Madras, ICMR, DST, DBT iii) International Symposium on “Changing Etiology of Emerging Infectious Diseases” (CEEID, February 2013) Funded by DST PURSE iv) WHO training program on techniques in diagnostic Microbiology 1-1-2012 to 31-1-2012, Funded by WHO. v) National Work Shop on “Applications of Molecular techniques in the diagnosis of infectious diseases”- Molecular Techniques for Medical Graduates (IAMM TN & Puducherry chapter) 10th – 14th June 2013

31. Code of ethics for research followed by the departments - UGC regulations on minimum standard and procedure for the award of M.Phil/Ph.D. degree – 2009 are followed.

32. Student profile programme-wise: Name of the Programme (refer to question Application Pass Selected no.4) received percentage

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

Male Female Male Female

M. Sc., Medical Microbiology 224 1 10 100% 100% 2012-2013 MD., Medical Microbiology 15 0 2 100% 100%

M. Sc., Medical Microbiology 226 3 5 0 100% 2011-2012 MD., Medical Microbiology 21 0 3 0 100% M. Sc., Medical Microbiology 283 3 9 100% 100% 2010- 2011 MD., Medical Microbiology 14 1 2 0 50% M. Sc., Medical Microbiology 401 0 7 100% 100% 2009-2010 MD., Medical Microbiology 10 1 2 0 100% M. Sc., Medical Microbiology 435 3 7 100% 100% 2008-2009 MD., Medical Microbiology 12 0 2 100% 100%

33. Diversity of students Name of the % of students % of % of % of Programme from the same students students students (refer to question no. university from other from from other 4) universities universities countries within the outside the State State M.Sc., Medical 2010-2013 35% 60% 5% Microbiology M.D., Medical 0% 100% 0% Microbiology M.Sc., Medical 2009-2012 40% 60% 0% Microbiology M.D., Medical 0% 100% 0% Microbiology M.Sc., Medical 2008-2011 45% 50% 0% Microbiology M.D., Medical 0% 100% 0% Microbiology M.Sc., Medical 2007-2010 50% 45% 5% Microbiology M.D., Medical 0% 0% 0% Microbiology

34. How many students have cleared Civil Services and Defence Services examinations, NET, SET, GATE and other competitive examinations? Give details category-wise.

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

Nil 35. Student progression Student progression Percentage against enrolled UG to PG -- PG to M.Phil. -- PG to Ph.D. Approx 40% Ph.D. to Post-Doctoral Approx 20% Employed · Campus selection · Other than campus recruitment 100% Entrepreneurs --

36. Diversity of staff Percentage of faculty who are graduates of the same university 100% from other universities within the State -- from universities from other States -- from universities outside the country -- 37. Number of faculty who were awarded M.Phil., Ph.D., D.Sc. and D.Litt. during the assessment period

D.Sc (Dr. Thangam Menon)

38. Present details of departmental infrastructural facilities with regard to a) Library - YES b) Internet facilities for staff and students - YES c) Total number of class room - 4 Nos. d) Class rooms with ICT facility - 4 Nos. e) Students’ laboratories - 4 Nos. f) Research laboratories - 4 Nos.

39. List of doctoral, post-doctoral students and Research Associates : Enclosed a) from the host institution/university – b) Ph.D. Full Time: c) Jeevan M. d) V. Naveen Kumar e) P.M. Punithavathy f) E. Padmasini

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

g) E. Sathish Kumar h) G. Kaushik Subramanian i) M. Saravanan j) Durgadevi k) B. Betsy Sowndarya Dass l) G. Sathyanarayanan m) Dhananczhian n) M. Lavanya o) P. Nagaraj p) Ph.D. Part Time: q) Jasmine Shahina r) Sathish Kumar s) Shankar t) Anuswedha u) Pushkala v) Amudhan w) Sekar x) Stalin y) Senthilnathan

b) from other institutions/universities Full time scholars a) Manju Bhashini b) Dinesh 40. Number of post graduate students getting financial assistance from the university. - 3 Nos.

41. Was any need assessment exercise undertaken before the development of new programme(s)? If so, highlight the methodology. ----- 42. Does the department obtain feedback from a. Faculty on curriculum as well as teaching-learning-evaluation? If yes, how does the department utilize the feedback?

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

Yes. Feedback received from the faculties is placed before the Departmental Committee to revise the curriculum.

b. Students on staff, curriculum and teaching-learning-evaluation and how does the department utilize the feedback? Students on staff – every academic year feedback is obtained by the IQAC and the findings are communicated to the faculty individually every year. The feedback is taken into account for confirmation/ promotion.

c. Alumni and employers on the programmes offered and how does the department utilize the feedback? YES – Representation from Industries are members of the Board of Studies

43. List the distinguished alumni of the department (maximum 10) Dr. A. Srikanth anand, USA Dr. S. Jayaram, India Dr. K. Udayasankar, USA Dr. Rauf Latif, USA Dr. S. Sumathy, USA Dr. Palani Kumar, USA Dr. Joseph Pushpa Innocent, India Dr. Dharmalingam, USA Dr. V.K. Krishnamoorthy, India Dr. Rajkumar Martin, Japan Dr. Murali, India Dr. Jaya, India Dr.KM. Ponnuvel, India, Dr. Sadheesh Kumar, USA Dr.S. Damodharan, Singapore Dr.M. Goplakrishnan, Malaysia.

44. Give details of student enrichment programmes (special lectures / workshops / seminar) involving external experts. Journal Club, Seminar conducted weekly

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

45. List the teaching methods adopted by the faculty for different programmes.

The teaching methods include lectures, group discussions, ICT, seminars and tutorials.

46. How does the department ensure that programme objectives are constantly met and learning outcomes are monitored? By periodical sessional tests, assignment, quiz, tutorials and counseling.

47. Highlight the participation of students and faculty in extension activities. Screening of school children for infections and nutritional deficiencies. Extension of Diagnostic facilities to hospitals for special investigations such as blood cultures for infective endocarditis, screening for drug resistant bacteria, identification of “difficult-to-identify” pathogens

Publication: Nandhakumar B, Thangam Menon, C.P Girish Kumar. A new henna based mediun for the differentiation of Cryptococcus neoformans. Journal of Medical Microbiology 2007; 56 (4) :568 Malathy B, Thangam Menon. Evaluation of crystal violet impregnated fiter paper strips for transport and selective isolation of beta haemolytic streptococci. Journal of Medical Microbiology 2007; 56 (4):569-70 Thangam Menon, Nandhakumar B, Shanmugasundaram S, Malathy B. Endocarditis due to Group C Streptococcus dysgalactiae sub sp equisimilis (GCSDSE) – A case report. Journal of Post Graduate Medicine January 2008 Vol 54 (1): 64-65 Nandhakumar B, Thangam Menon, Shanmugasundaram S ,Ravishankar G. Pacemaker pocket infection associated with septicaemia caused by Pseudomonas aeruginosa –A case report. Int J Infect Dis, 2008, 12: 1. 107-108 Kumar S S, Vengadassalapathy L, Menon T. Prosthetic valve endocarditis caused by Acinetobacter baumannii complex. Indian J Pathol Microbiol 2008;51:573 C.P.G.Kumar, Thangam Menon et.al., Anti-Candida antibodies and candidemia in ninety patients with HIV/AIDS and cancer. Journal de Mycologie Medicale 2007, 17, 50-53. Mullai V, Thangam Menon. Bactericidal activity of different types of honey against clinical and environmental isolates of Pseudomonas aeruginosa. Journal of Alternative & Complementary Medicine - 2007 ; 13:4, 439-441. 15

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

Thangam Menon, B.Nandhakumar. Nosocomial endocarditis caused by Acinetobacter baumannii Helix review series - Infectious diseases 2007; 2(9): 20-21 V.Sagar, R.Kumar, NK Ganguly, Thangam Menon and Anuradha Chakraborti. Distantly related SIC (DRS) is far less divergent than SIC of Group A Streptococci, J.Bacteriology; 2007, Vol 189, No 7, 2933-2935. Lloyd and Menon. speA and speC toxin genes among group A streptococcus isolates from school children. J Med Microbiol.2007; 56: 1574-1575 Charmaine A.C. Lloyd, Swarna E. Jacob and Thangam Menon. Antibiotic Resistant b-hemolytic Streptococci. Indian Journal of Pediatrics, 2007, 74: 1077- 1080 Thangam Menon, Charmaine Lloyd, Balaraman Malathy, Varja Sakota, Delois Jackson and Bernard Beall. emm type diversity of β-haemolytic streptococci recovered in Chennai, India. Journal of Medical Microbiology, 2008; 57: 540 – 542 Nandhakumar B, Thangam Menon, Pierre Edouard Fournier and Didier Raoult Bartonella quintana and Coxiella burnetii as Causes of Endocarditis, India Emerging Infectious Diseases Vol. 14, No. 7, July 2008 1168-1169. T. Menon, V.G. Sivakumar. Changing trends of oropharyngeal carriage of Candida species in HIV patients in Chennai, South India. International Scientific Exchange, 13th International Conference on Infectious Diseases, 2008. Pg 59. Umamaheswari and Thangam Menon. Candida fermentati from HIV patients in Chennai, South India International Journal of Infectious Diseases (2008) 12(6): e153-4. C.Lloyd, Nandhakumar B, Thangam Menon. Vir types of Streptococcus pyogenes in Chennai city, South India. Journal of Medical Microbiology; 57 (2008), 1176- 1177 B Nandhakumar, S Senthilkumar, Thangam Menon, , and S.Shanmugasundaram. Penicillin-resistant viridans group streptococci from blood cultures of infective endocarditis patients in South India. International Journal of Antimicrobial Agents, 32: 6, 2008, 543-544. Thangam Menon, Nandhakumar B, Shanmugasundaram S, Malathy B. Endocarditis due to Group C Streptococcus dysgalactiae sub sp equisimilis -A case report. Journal of Post Graduate Medicine; January 2008 Vol 54 Issue 1, 64-65. C. P. Girish Kumar, Thangam Menon, S. Rajasekaran, B. Sekar and D. Prabu. Carriage of Candida species in oral cavities of HIV infected patients in South India. Mycoses, 2008: 52, 44–48 V. G. Sivakumar ;P. Shankar; K. Nalina ,Thangam Menon. Use of CHROMagar in the Differentiation of Common Species of Candida. Mycopathologia, 2008, Vol 167, 1 ( 2008 ), pg 47 Kumar,CPG, Prabu,D., Hitani H; Mikami Y; Menon T. Environmental isolation of Cryptococcus neoformans and Cryptococcus gattii from living trees in Guindy National Park, Chennai, South India. Mycoses 2010;53(3):262-4.

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

Thangam Menon, Monica Herrera, Shankar Periasamy, Veena Palanivelu, Rajasekaran Sikhamani and Brian Wickes. Oral candidiasis caused by Kodamaea ohmeri in a HIV patient in Chennai, India. Mycoses 2010;53(5):458-9. Thangam Menon and D.Prabu. Groups C and G Streptococci - Friend or foe? Indian Pediatrics 2010; 47(9):809. Thangam Menon, Senthilkumar, Venkatasalapathy. Native valve endocarditis caused by a non toxigenic strain of C.diphtheriae. Indian Journal of Pathology & Microbiology 2010; 53(4):899-900. Malathy B and Thangam Menon. Restriction fragment patterns and emm types of group G streptococci. J Med Microbiol. 2010 Aug; 59(Pt 8):996-7. Sharath Asokan, TK Rathinasamy, N Inbamani, Thangam Menon, S Senthil Kumar, Pamela Emmadi, R Raghuraman. Mechanism of oil pulling – an invitro study. Indian Journal of Dental Research 2011, 22: 34-37. D Prabu and Thangam Menon. Genotypic characterization of toxigenic group C and G streptococci isolated in Chennai, South India. Folia Microbiol, June 2011. Subramaniam Senthilkumar,V. Naveenkumar, Thangam Menon and Geetha Subramanian. Granulicatella adiacens as a cause of native valve endocarditis. Biomedicine: 2012; 32(1): 133 – 134. Padmaja Pathipati; Prem Sekar; Thara Francis; Naveen Kumar; Thangam Menon; Kotturathu, Mammen Cherian. Usefulness of 16S rDNA sequencing for the diagnosis of infective endocarditis caused by Corynebacterium diphtheriae. Journal of medical microbiology 2012;61(Pt 8):1159-61. Menon T, Naveen Kumar V. Catonella morbi as a cause of native valve endocarditis in Chennai, India. Infection. 2012 Feb 25. P. M. Punithavathy, K. Nalina, Thangam Menon. Antifungal susceptibility testing of Candida tropicalis biofilms against fluconazole using calorimetric indicator resazuri. Indian Journal of Pathology & Microbiology Vol 55, Issue 1, Jan- March 2012. Poovazhagi V, Ezhilarasi S, Thangam Menon, Naveen kumar V, Chamundeeswari, Mohamed Meeran. Invasive aspergillosis and nocardial pneumonia in an immunocompetent child. Pediatric Oncall. 2012 March 1; 9: Issue 3. Art # 17. V Naveenkumar, A Nisha, Thangam Menon. Comparison of sodA and 16S rDNA sequencing for accurate species-level identification of viridans group streptococci (VGS) isolated from patients with infective endocarditis. BMC Infectious Diseases 2012, 12 (1):73 Bajoria, Thangam Menon. Streptococcus invasive locus (sil) in Group A Streptococcus causing non-invasive infections in Chennai, South India. BMC Infectious Diseases 2012, 12(1):62 PM Punithavathy, Thangam Menon. Characterization of gene family that mediates the adhesion of biofilms formed by Candida tropicalis isolated from HIV and non-HIV patients. BMC Infectious Diseases 2012, 12(1):8 D Prabu and T Menon. Virtyping for the analysis of Group C and G Streptococcal genotypes. IJID Vol 16 e 570 – e 571, July 2012.

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

D Prabu and T Menon, Genotyping of Erythromycin Resistant Group C and G Streptococci isolated in Chennai, South India.IJMR 2013; 137(1):164-168. Bajoria, D. & Menon, T. The HLA Class II Associations with Rheumatic Heart Disease in South Indian Patients: A Preliminary Study. Journal of Clinical & Diagnostic Research, 2013, 7(2):302-304 Thangam Menon, V. Naveen Kumar, Muthulakshmi Sekar, Anne Princy. NDM- 1 producers as causative agents of nosocomial urinary tract infections. Journal of Medical Microbiology, May 2013. Jeevan Malayan, Balaji Selvaraj, Aparna Warrier, Sambantham Shanmugam, Manikannan Mathayan, Thangam Menon. Anti-Mumps virus (MuV) activity by extracts of Mimosa pudica, a unique Indian Medicinal Plant. Indian Journal of Virology, 2013. Jeevan Malayan, Sambantham Shanmugam, Thangam Menon. Characterization of Mumps virus genotype C among the patients with mumps in India. Indian Journal of Medical Microbiology, 2013. Jeevan Malayan, Aparna Warrier, Padmasani Venkat Ramanan, Sanjeeva Reddy N, and Elanchezhiyan Manickan. Unnoticeable Mumps Infection in India: Does MMR Vaccine Protect against Circulating Mumps Virus Genotype C? World Academy of Science, Engineering and Technology 2012; 71: 1416-1422. Jeevan M, Nasreen N, Dinesh S, Mythily V Durgadevei H and Elanchezhiyan Manickan Anti HBV activity of HD-03/ES, a herbal medicine by interference of HBsAg binding to its receptor. Journal of Pharmacy Research, 5(8), 4348-4352, 2012. Jeevan Malayan, Nasreen Nawabjan, Dinesh Subramaniam and Elanchezhiyan Manickan Prevention of hepatitis b virus (hbv) replication by extracts of mimosa pudica, an unique Indian medicinal plan. International Journal of Medical and Pharmaceutical Virology (article in press). Rangasamy Balamuragan, A.Dhanasezhian, Elanchezhiyan Manickan Immune Modulatory and antioxidant properties of Indian medicinal herb Phyllanthus amarus, lin . 15(1), 18-27, 2012. M. Manikannan, P. Durgadevi, S. Subramaniyan and Elanchezhiyan Manickan. Abundant CD4 Th-2 cytokine stimulation by medicinal plant Pongamia pinnata Linn. on human peripheral blood mononuclear cell (PBMC). International Journal of Plant Physiology and Biochemistry 4(2):27-32, 2012. M. Manikannan, R. Balamurugan, S. Dinesh, H. Durgadevi, A. Jeevan, R. Varatharajan, Elanchezhiyan Manickan. Activation and stimulation of Th2 type CD4 cells by extracts dried from Pongamia pinnata Linn. an Indian medicinal plant. Indian journal of Applied Microbiology, 27-33. 2011. Rangasamy Balamuragan, Subramanian Dinesh, Parthasarathy Durgadevi, Hanna Leke Elizebeth, Shusamma Jadav, Smita Kulkarani, Ramesh Paranjape and Elanchezhiyan Manickan, Phyllanthus amarus extracts inhibit HIV-1Replication in MT-2 Cell line, International Journal of Medical and Pharmaceutical Virology. 1(2), 26-31 2011.

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

M. Manikannan, R. Balamurugan, R. Varatharajan, S. Dinesh, Elanchezhiyan Manickan. Nitric oxide induce IL-10 a CD4+ T helper type-2 (Th-2) cytokines in human PBMC. Journal of Pharmaceutical and Biomedical sciences, 7, 1-6. 2011. S. Dinesh, M. Lavanya, and Elanchezhiyan Manickan. Leukotriene B4 (LTB4), an important innate immune molecule stimulated by Padinatetrastromatica. Indian Journal of Applied Microbiology. 14(1) 2011. Dinesh Subramaniam, Nasreen Nawabjan, Jeevan Malayan, Lavanya Mohanam, Mythily Vaikuntam and Elanchezhiyan Manickan. Anti Hepatitis B Virus (HBV) activity of marine brown algae, Padina tetrastromatica. Veteniary Science Research 2 (2): 25-29, 2011. S. Dinesh, S. Lavanya, M. Jeevan, V. Mythily, and Elanchezhiyan Manickan. Strong Anti Hepatitis B Virus (HBV) activity of Padina tetrastromatica, a marine brown algae. ENVIS. 9:2-5, 2011 S. Dinesh, S. Sumathi, M. Manikannan, R. Balamurugan, T. Ravindran, J. Balasubramaniam, V. Mythily and Elanchezhiyan Manickan Interleukin-10: A Potent Antibody Promoting Cytokine Induced by Grateloupia lithophila on Human PBMC. International Journal of Medical and Pharmaceutical Virology. 1:1-7, 2011. R. Balamurugan, M. Manikannan, S. Dinesh, P. Rajendran, V. Ramachandran and Elanchezhiyan Manickan. Comparative evaluation of Immune Modulation properties of leaf versus seed extracts of Phyllanthus amarus. Linn. Biomedicine 2009; 29 (1): 56-61. M.Manikannan, K.Prethesh raj, R. Kandan, S. Balamurugan, R. Dinesh, S. Varatharajan, R. Rejendran, P. Elanchezhiyan Manickan. Immune Modulation properties of Andrographis paniculata Linn. on human PBMCs. Indian Journal of Applied Microbiology 10(1): 32-38,2009 M. Manikannan, R.Balamurugan, R. Varatharajan, S. Dinesh , P. Rajendran, and Elanchezhiyan Manickan Immune stimulation properties of Pongamia pinnata, Linn on human PBMC. Proceeding of Indian Association of Biomedical scientists. 2007 C Anitha, A Santhoshkumar, Padma Krishnan, BVR Tata, S Senthamarai, Sivasankari, V Venugopal, Rajasekharan Sikhamani, M Pushkala. Effect of garlic oil on biofilm formation by Pseudomonas spp. isolated from lower respiratory tract infection from HIV and non-HIV populations using confocal laser scanning microscopic analysis. Journal of Infectious Disease. (Accepted) Kesavaram Padmavathy, Krishnan Padma and Sikhamani Rajasekaran. Extended- spectrum β-lactamase/AmpC-producing uropathogenic Escherichia coli from HIV patients: Do they have a low virulence score? J. Med. Microbiol. March 2013 vol. 62 no. Pt 3 345-351. Nagarajan Abimanyu, Saravanan Murugesan and Padma Krishnan. Emergence of Methicillin-Resistant Staphylococcus aureus ST239 with high-level mupirocin resistance in a tertiary care center in Chennai, South India. J. Clin. Mcrobiolol. 2012, 50(10):3412.

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

Nagarajan A, Saravanan M, Betsy Sowndarya Dass B, G Sivakumar, Bhanu Sinha and Padma Krishnan. Mupirocin resistant HA-MRSA with inducible clindamycin resistance causing skin infections in a tertiary care centre from Chennai, South India. International Conference on Emerging Infectious Diseases 2012 poster and oral presentation abstracts. Emerg Infect Dis [serial on the Internet]. 2012 Mar. http://wwwnc.cdc.gov/eid/pdfs/ICEID2012.pdf. Gopalakrishnan Kaushik, K Arunkumar, G Sivakumar, R Rajasomasundharam, Padma Krishnan. Integrons as surrogate marker for multi drug resistance in gram negative bacilli. BMC Infectious Diseases 2012 12(Suppl 1):P72. Kesavaram Padmavathy, Padma Krishnan, Sikhamani Rajasekaran. Incidence of bla genes among uropathogenic Escherichia coli isolates from HIV and non-HIV patients in South India. BMC Infectious Diseases 2012 12(Suppl 1):P21. Mahalakshmi Krishnan, Padma Krishnan, Subashini Natarajan. Occurrence of Porphyromonas gingivalis fimA type II and prtC genotype among periodontitis patients. BMC Infectious Diseases 2012 12(Suppl 1):P22. Nagarajan A, K Arunkumar, M Saravanan, G Sivakumar and Padma Krishnan. Detection of fusidic acid resistance determinants among Staphylococcus aureus isolates causing skin and soft tissue infections from a tertiary care centre in Chennai, South India. BMC Infectious Diseases 2012, 12 (Suppl 1):P45 doi:10.1186/1471-2334-12-S1-P45. Nagarajan A, K Arunkumar, M Saravanan, G Sivakumar and Padma Krishnan. PVL positive methicillin resistant Staphylococcus aureus breast abscess infection among post-partum women in Chennai, South India. BMC Infectious Diseases 2012, 12(Suppl 1):O13 doi:10.1186/1471-2334-12-S1-O13. Betsy S. Dass B, Nagarajan A., Padma Krishnan and G Sivakumar. Clindamycin resistance among Staphylococcus aureus causing skin and ear infections from Chennai, South India. BMC Infectious Diseases 2012, 12 (Suppl 1):P70 doi:10.1186/1471-2334-12-S1-P70. C Anitha A Santhoshkumar Padma Krishnan BVR Tata S Senthamarai Sivasankari V Venugopal Rajasekharan Sikhamani M Pushkala SK Amshavathani. A confocal microscopic study on biofilm formed by Pseudomonas spp. isolated from lower respiratory tract infection from HIV and non-HIV populations. BMC Infectious Diseases 2012 12(Suppl 1):P56. Anitha Chandrahausan, Padma Krishnan, Rajasekharan Sikhamani and Pushkala Murugavel. Resistance patterns of Pseudomonas aeruginosa isolated from HIV and Non-HIV patients with lower respiratory tract infections. Internet Journal of Medical Update 2012 January;7(1):8-12. S.K Jasmine Shahina, P.V.Meenakshi, Padma Krishnan. Screening of cell phones and stethoscopes of health care workers for the presence of Methicillin Resistant Staphylococci. International Journal of trends in Applied Microbiology and Biotechnology. Vol 1, issue 12 Dec 2012. Padmavathy Kesavaram; Padma Krishnan; Rajasekaran Sikhamani. Detection of Extended- Spectrum β-Lactamases and AmpC β-Lactamase Production in

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

Escherichia coli Causing Urinary Tract Infection among HIV and non-HIV Patients. American Medical Journal. 2011; 2(1): 54-58. Kumarasamy K and Padma Krishnan. A report of CMY-2 AmpC β-lactamase producing Salmonella enterica serovar Typhi from India. J. Antimicrob Chemother Advance Access published December 6, 2011 Karthikeyan K, Toleman M, Giske CG, Padma Krishnan et al. First report of the co-existence of blaOXA-48 or blaOXA-48-like with blaNDM-1 in Enterobacteriaceae from India. Clin Microbiol Infect 2010; 16: S187.

K. Karthikeyan, M. Thirunarayan and Padma Krishnan. Co-existence of blaOXA-23 with blaNDM-1and armA in clinical isolates of Acinetobacter baumannii from India. J Antimicrobial Chemotherapy. (2010)65 (10): 2253-2254. Nagarajan M. Ananthi, P. Krishnan, U. Reischl, C. Prabha, H.-J. Lindeb. Emergence of Panton–Valentine leucocidin among community- and hospital- associated meticillin resistant Staphylococcus aureus in Chennai, South India. Journal of Hospital Infection, 2010: 1–2. Kumarasamy K. K., M. A. Toleman, T. R. Walsh, J. Bagaria, F. Butt, R. Balakrishnan, U. Chaudhary, M. Doumith, C. G. Giske, S. Irfan, P. Krishnan et al., Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis. 2010; 10: 597–602. Nagarajan Abimanyu, Saravanan Murugesan, Padma Krishnan. High Prevalence of Exfoliative Toxins among Carrier Isolates of Staphylococcus aureus from Healthy Individuals from Various Communities in Chennai, South India. Indian J Microbiol .DOI 10.1007/s12088-013-0360-9. Nagarajan Abimanyu, Arunkumar Krishnan, Saravanan Murugesan, Kaushik Subramanian G,Sivakumar Gurumurthy, Padma Krishnan. Use of Triplex Pcr For rapid Detection of Pvl and Differentiation of MRSA from methicillin Resistant Coagulase Negative Staphylococci. Journal of Clinical and Diagnostic Research, 2013 February, Vol-7(2): 215-218. Kesavaram Padmavathy; Aruppukottai R Susethira; Rajasekaran Sikhamani; Padma Krishnan; Kailapuri G Murugavel; Uma Shanmugasundaram. IgM ELISA: A Better Choice for the Detection of Active Chlamydia Trachomatis Infection among HIV Patients. Journal of Clinical and Diagnostic Research. 2012 February, Vol-5(9). Krishnan Mahalakshmi, Padma Krishnan, S.C. Chandrasekaran, K.H. Panishankar, Natarajan Subashini. Prevalence of Periodontopathic Bacteria in the Subgingival Plaque of a South Indian Population with Periodontitis. Journal of Clinical and Diagnostic Research. 2012 May (Suppl-2), Vol-6(4): 747-752. S. K. Jasmine Shahina, Padma Krishnan, G. C. Indumathi, Summera Rafiq. Evaluation of Hi-chrome medium for screening of asymptomatic carriers of MRSA from the community. Indian Journal of Applied Microbiology, 2012. Anitha C, Padma Krishnan, Rajasekaran, Pushkala M. Invitro antibacterial activity of essential oils against MDR isolates of Pseudomonas spp. From lower

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology respiratory tract infections among HIV and Non-HIV populations. Indian Journal of Applied Microbiology. 2011: 13(1): 24 -31. Gupta V, Kumarasamy K, Gulati N, Garg R, Padma Krishnan and J. Chander. Phenotypic/Genotypic characterization of AmpC β-lactamases in nosocomial isolates of Klebsiella pneumoniae from India. Indian J Medical Research (Accepted). Karthikeyan K, Thirunarayan M, and Padma Krishnan CTX-M15 type ESBL producing Salmonella from a paediatric patient in Chennai, India. Indian J Med Res. 2011; 134: 56-58. Padma Krishnan, Rajendran P, Sambandan ap, Anitha C, Chavda RK and Khobragade KJ. Evaluation of Co-Amoxiclav against Streptococus pneumoniae and Haemophilus influenzae from Paediatric cases of Acute Respiratory Infections. Journal of Indian Medical Association. 2011: 109(4): 241. Padma Krishnan, M Stalin, S. Balasubramanian. Changing trends in antimicrobial resistance of Salmonella enterica serovar typhi and Salmonella enterica serovar paratyphi A in Chennai. IJPM 2009; 52 (4). K. Mahalakshmi, Sharanya Srivathsan, Kownhar Hayath, Padma Krishnan. Comparative studies on viridans streptococci isolated from periodontitis patients and healthy subjects: detection of virulence protein by SDS – PAGE. Biomedicine. 2009; 29 (1): 40 – 42. R. Amutha, Padma Krishnan, T. Murugan and M. P. Renuga Devi. Studies on multidrug resistant Pseudomonas aeruginosa from pediatric population with special reference to extended spectrum beta lactamase. Indian journal of science and technology.vol2 no.11 Nov 2009. Padma Krishnan, M Stalin, S. Balasubramanian. Changing trends in antimicrobial resistance of Salmonella enterica serovar typhi and Salmonella enterica serovar paratyphi A in Chennai. IJPM 2009; 52 (4). K.Mahalakshmi, Sharanya Srivathsan, Kownhar Hayath, Padma Krishnan. Comparative studies on viridans streptococci isolated from periodontitis patients and healthy subjects: detection of virulence protein by SDS – PAGE. Biomedicine. 2009; 29 (1): 40 – 42. R. Amutha, Padma Krishnan, T. Murugan and M. P. Renuga Devi. Studies on multidrug resistant Pseudomonas aeruginosa from pediatric population with special reference to extended spectrum beta lactamase. Indian Journal of Science and technology.vol: 2 no.11 Nov 2009. Roopa Subramanian, Padma Krishnan, Rashita Begum, Dharmalingam S, Usha Anand Rao and S. P. Thiyagarajan. Studies on the prevalence of H. pylori and comparision of the various diagnostic procedures. Indian Journal of Applied Microbiology, 2008: 8(1): 19 – 21 Padma Krishnan, Anusha A, and MA Thirunarayanan. Studies on Multi Drug Resistant clinical isolates of Non – fermenting Gram Negative Bacilli: Detection of ESBL, AmpC and Metallo Beta Lactamase. Proceeding of 28th annual conference of IABMS Oct – 2007.

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

Padma Krishnan, Anusha A, and MA Thirunarayanan. Studies on Multi Drug Resistant clinical isolates of Non – fermenting Gram Negative Bacilli: Detection of ESBL, AmpC and Metallo Beta Lactamase. Proceeding of 28th annual conference of IABMS Oct – 2007. Sekar R, Mahalakshmi D, Srivani R, Shankar EM, Vignesh R. High rate of detection of highlevel aminoglycoside resistant enterococci from Urinary tract specimens in south India. Intl. Journal of Antimicrobial Agents (2008) 380-399. Sekar R, Srivani R, Low recovery rates of high level aminolycoside resistant enterococci could be attributable to restricted usage of aminoglycoside in Indian settings. J. Med. Microbiol(2008). 57. 397-398. Sekar R. Srivani R. Sivashankar M. Suresh A. Higher Incidence of Enterococcus faecium and Ampicillin Resistance among the Gut Commensal Enterococci Isolated following Oral Antibiotic Therapy. Chemotherapy 2011;57:54–55 A Suresh, G Muthu, R Srivani , Anand Moses (2011) Aerobic bacterial resistance in diabetic foot ulcer from Chennai. International Journal of Pharma and Bio Sciences 2(2) 517-528 Gopal Muthu, Arumugam Suresh, Gnadesikan Sumathy and Ramesh Srivani. Studies on antimicrobial susceptibility pattern of Salmonella Isolates from Chennai, India. International Journal of Pharma and Bio Sciences, 2011. vol2:435-442 Gopinath P Geethapriya S Jayakeerthana KH & R Srivani (2011) Detection of certain virulence attributes and antimicrobial resistance pattern among clinical isolates of Acinetobacter baumannii. International Journal of Pharma and Bio Sciences 2(3) 501-507 Arumugam Suresh, Gopal Muthu, Gopalakrishnan Suresh, Ravikanth Premnath, Prakasam Gopinath, Anand Moses, Srivani Ramesh. Screening of antibacterial properties of Indian medicinal plants against multi drug resistant diabetic foot ulcer isolates. International Journal of Phytopharmacology. 3(2), 2012, 139-146 E Sathish Kumar, R Esther Mary Selvam, S Srivani Ramesh. Salmonella enterica serovar Typhi in breast abscess: A case report. Indian Journal Pathology and microbiology. 2012 55: 608-609 Gopinath Prakasam, Anusha Rohit, Sathish Kumar, S. Srivani Ramesh. Siderophore production among clinical and healthy skin isolates of Acinetobacter species. Indian J Med Microbiol 2013; 31:208-209. Gopinath Prakasam, Lakshmi Priya, S. Srivani Ramesh. Efficacy of disinfectants on clinical isolates of Acinetobacter species. Indian J Med Microbiol 2013; 31:209- 210. Gopinath Prakasam, Anusha Rohit, S. Srivani Ramesh. Rhamnolipid production among clinical and skin isolates of healthy individuals of Acinetobacter species-The first report. Int J Appl Basic Med Res 2013; 3:133.

48. Give details of “beyond syllabus scholarly activities” of the department. Training in other research institutes /hospitals

NAAC Reaccreditation - Evaluative Report School of Basic Medical Sciences Department of Microbiology

49. State whether the programme/ department is accredited/ graded by other agencies? If yes, give details. The department is involved in studies on drug susceptibilities which has assisted in generating data on drug resistant bacteria in this geographical region in addition to research in drug development particularly with reference to anti-HIV activities of marine extracts. 50. Briefly highlight the contributions of the department in generating new knowledge, basic or applied. The Department has also standardized techniques for diagnosis in infective endocarditis and several Cardiology units in city hospitals refer cases for blood culture. 51. Detail five major Strengths, Weaknesses, Opportunities and Challenges (SWOC) of the department. Strength: Wide range of research activities, Collaboration with hospitals, large student numbers, well equipped laboratories.

Weakness : lack of a hospital attached to this institute 52. Future plans of the department. Development of molecular methods for diagnosis of infectious diseases