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PROGRESS in NEUROSCIENCE PINS “CNS Lymphatic Drainage In
PROGRESS IN NEUROSCIENCE PINS Seminar Series of the Brain & Mind Research Institute Weill Cornell Medical College (WCMC) & The Graduate Program in Neuroscience of WCMC and Sloan Kettering Institute Thursday, 12/8/16, 4 PM, coffee at 3:45 PM Uris Auditorium “CNS lymphatic drainage in health and disease” Jonathan Kipnis, Ph.D., Center for Brain Immunology and Glia (BIG), Harrison Distinguished Teaching Professor of Neuroscience and Chair, Department of Neuroscience, University of Virginia Abstract The central nervous system was considered to be devoid of classical lymphatic drainage. We recently challenged that paradigm by demonstrating the presence of a lymphatic vasculature in the surrounding of the brain called the meninges. We demonstrated that lymphatic vessels, expressing the markers for lymphatic endothelial cells (LEC; i.e Lyve-1, Prox1, podoplanin, VEGFR3 and CCL21) are located along the dural sinuses. They present features of initial lymphatics, and, importantly, drain fluids, macromolecules and immune cells from the cerebrospinal fluid and the CNS parenchyma into the deep cervical lymph nodes. Our recent efforts are concentrated on understanding the role of meningeal lymphatic vessels in CNS function in health and disease. Our results suggest that the drainage into the deep cervical lymph nodes might play different roles at different stages of several neurological diseases. Understanding the function of the lymphatic drainage in CNS might shed a new light on neurological disorders and offer new therapeutic targets. Recent Relevant Publications: 1. Gadani SP, Walsh JT, Smirnov I, Zheng J and Kipnis J. (2015) The glia-derived alarmin IL-33 orchestrates the post CNS injury immune response and promotes recovery. -
Quarterly Report: Second Quarter 2017
QUARTERLY REPORT: 2ND QUARTER 2017 Q2 2017 Research Consortium Welcomes Three New Members The Brain’s 2 Phyllis Rappaport Updates Former College Classmates Lymphatic System 3 Modern science has an incredibly thorough understanding of the human body. It is J. McLaughlin’s ‘Sip ’n Shop’ hard to imagine that any organ or system could exist within the body that has yet to be Fundraiser discovered. Yet this is exactly what happened in 2015, when researchers discovered 4 lymphatic vessels around and within the brain. Living with Alzheimer’s Film The lymphatic system exists throughout the body. Part of the immune system, it consists Screening of a network of channels (vessels) and glands called “nodes.” Nodes create immune cells 5 to help the body fight infection. The vessels carry fluid containing these immune cells, as well as pathogens and harmful cellular waste products, away from organs. Until recently, CaringKind Alliance Update lymphatic vessels had never been observed in or around the brain. While there were other 5 known ways—such as immune cells called macrophages—for waste products to be Extra Sets of Hands cleared from the brain, researchers had trouble explaining the volume of clearance they observed without a lymphatic system. 5 Cure Alzheimer’s Fund A recent study at the University of Virginia by Jonathan Kipnis, Ph.D., and his colleagues Heroes Antoine Louveau, Ph.D., and Tajie Harris, Ph.D., shed new light on this problem. Using a new method of examining the meninges, a membrane that covers the brain, they 6 discovered there was in fact a network of lymphatic vessels surrounding the brain. -
2018 Winter Newsletter
Holiday Gift Ideas A Q&A wth Alan Arnette Plan Your Giving Now Celebrate the reason for the season Arnette is a mountaineer, speaker Make giving a commitment with a gift that gives back and Alzheimer’s advocate to Cure Alzheimer's Fund WINTER SEASON 2018 THE CASE FOR HOPE Panel Explores the Path Forward in Alzheimer’s Research at Our 8th Annual Scientific Symposium THE CASE FOR HOPE SCIENCE PANEL EXPLORES THE PATH FORWARD IN ALZHEIMER’S RESEARCH The 8th Annual Cure Alzheimer’s Fund Symposium featured award-winning NPR science writer Jon Hamilton moderating a discussion between Drs. Ron Petersen, Bob Vassar and Teresa Gomez-Isla on the Case For Hope in Alzheimer’s disease research. Co-Chairman Jeff Morby started the meeting by announcing that for the frst time. She remembered being impacted by learning Cure Alzheimer’s Fund had just received the designation of Top that the disease can steal one of the “greatest treasures we have 10 Best Medical Research Organizations by nonproft watchdog as human beings—our memories.” Charity Navigator. After providing the audience with an update of CureAlz's results, including $75 million distributed for 340 Progressing Through Challenges research grants to 127 of the world’s leading researchers, he then introduced Dr. Rudy Tanzi, who introduced the panel: Dr. Petersen The panelists described the challenge of connecting the events as a champion for scientists whose policy work has been pav- happening in the brain to the symptoms experienced by patients. ing the way for clinical trials that target amyloid before the onset All three of the scientists explained that amyloid plaques and of symptoms, Dr. -
2020 Annual Report Our Mission
2020 ANNUAL REPORT OUR MISSION Cure Alzheimer’s Fund is a nonprofit organization dedicated to funding research with the highest probability of preventing, slowing or reversing Alzheimer’s disease. Annual Report 2020 MESSAGE FROM THE CHAIRMEN 2 THE MAIN ELEMENTS OF THE PATHOLOGY OF ALZHEIMER’S DISEASE 9 RESEARCH AREAS OF FOCUS 10 PUBLISHED PAPERS 12 CURE ALZHEIMER’S FUND CONSORTIA 20 OUR RESEARCHERS 22 2020 FUNDED RESEARCH 32 2020 EVENTS TO FACILITATE RESEARCH COLLABORATION 68 MESSAGE FROM THE PRESIDENT 70 2020 FUNDRAISING 72 2020 FINANCIALS 73 OUR PEOPLE 74 OUR HEROES 75 AWARENESS 78 IN MEMORY AND IN HONOR 80 SUPPORT OUR RESEARCH 81 Message From The Chairmen Dear Friends, 2020 was a truly remarkable year: • Despite the COVID-19 pandemic, we were fully functional with all of our wonderful staff working from their homes. We were able to pay and retain all of our employees, thanks to the generosity of our directors. • And, amazingly, we were able to increase our fundraising by 2%, in this very tough year, to $25.9 million provided by 21,000 donors. • The above enabled us to fund 59 research grants totaling $16.5 million. We have, since inception, financed 525 grants, representing $125 million in cumulative funding through March 2021. • We have one therapy well on its way through clinical trials, and another expected to enter clinical trials in late 2021 or 2022. Our Scientists Approximately 175 scientists affiliated with 75 institutions around the world are working on our projects. They are profiled in the pages that follow. Many labs faced funding challenges during COVID-19, and our consistent support was very beneficial for ensuring that vital staff could be retained and scientific progress was preserved. -
University of Copenhagen, Copenhagen, Denmark
Understanding the functions and relationships of the glymphatic system and meningeal lymphatics Louveau, Antoine; Plog, Benjamin A.; Antila, Salli; Alitalo, Kari; Nedergaard, Maiken; Kipnis, Jonathan Published in: The Journal of Clinical Investigation DOI: 10.1172/JCI90603 Publication date: 2017 Document version Publisher's PDF, also known as Version of record Document license: Unspecified Citation for published version (APA): Louveau, A., Plog, B. A., Antila, S., Alitalo, K., Nedergaard, M., & Kipnis, J. (2017). Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. The Journal of Clinical Investigation, 127(9), 3210-3219. https://doi.org/10.1172/JCI90603 Download date: 26. Sep. 2021 Understanding the functions and relationships of the glymphatic system and meningeal lymphatics Antoine Louveau, … , Maiken Nedergaard, Jonathan Kipnis J Clin Invest. 2017;127(9):3210-3219. https://doi.org/10.1172/JCI90603. Review Series Recent discoveries of the glymphatic system and of meningeal lymphatic vessels have generated a lot of excitement, along with some degree of skepticism. Here, we summarize the state of the field and point out the gaps of knowledge that should be filled through further research. We discuss the glymphatic system as a system that allows CNS perfusion by the cerebrospinal fluid (CSF) and interstitial fluid (ISF). We also describe the recently characterized meningeal lymphatic vessels and their role in drainage of the brain ISF, CSF, CNS-derived molecules, and immune cells from the CNS and meninges to the peripheral (CNS-draining) lymph nodes. We speculate on the relationship between the two systems and their malfunction that may underlie some neurological diseases. Although much remains to be investigated, these new discoveries have changed our understanding of mechanisms underlying CNS immune privilege and CNS drainage. -
Bone Marrow Transplant Alleviates Rett Symptoms in Mice
Spectrum | Autism Research News https://www.spectrumnews.org NEWS Bone marrow transplant alleviates Rett symptoms in mice BY EMILY SINGER 19 MARCH 2012 Managing microglia: Mutant mice lacking the MeCP2 protein are small (left), while those bred to have a normal version of the MeCP2 protein in their myeloid cells ? precursors to microglia ? grow to normal size (right). A bone marrow transplant from healthy mice to those lacking the MeCP2 protein, which causes Rett syndrome in humans when mutated, extends lifespan and alleviates symptoms of the disorder, according to research published online 18 March in Nature1. Researchers found that microglia, which take root in the brain after the transplant, are the most important component of the treatment. These cells are known to act as scavengers that clean up cellular debris, but recent research suggests they also have other roles, including influencing neural transmission and development of the synapse, the junction between neurons. Rett syndrome is a rare disorder caused by deletion or mutation of the X-linked MeCP2 gene and occurs almost exclusively in females. Symptoms emerge around 6 to 18 months of age and include breathing problems, intellectual disability, seizures, language deficits and other autism-like impairments. Mice in which the MeCP2 gene has been knocked out in all or a subset of cells mimic many of the features of Rett syndrome. 1 / 4 Spectrum | Autism Research News https://www.spectrumnews.org Following treatment, abnormal breathing patterns and apnea, a temporary interruption in breathing seen in both MeCP2 knockout mice and children with Rett syndrome, are diminished in the knockout animals. -
Human and Nonhuman Primate Meninges Harbor Lymphatic Vessels
SHORT REPORT Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI Martina Absinta1†, Seung-Kwon Ha1†, Govind Nair1, Pascal Sati1, Nicholas J Luciano1, Maryknoll Palisoc2, Antoine Louveau3, Kareem A Zaghloul4, Stefania Pittaluga2, Jonathan Kipnis3, Daniel S Reich1* 1Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States; 2Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States; 3Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, United States; 4Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States Abstract Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI. On T2-FLAIR and T1-weighted black-blood imaging, lymphatic vessels enhance with gadobutrol, a gadolinium-based contrast agent with high propensity to extravasate across a permeable capillary endothelial barrier, but not with gadofosveset, a blood-pool contrast agent. The topography of these vessels, running alongside dural venous sinuses, recapitulates the meningeal lymphatic system of rodents. In primates, *For correspondence: meningeal -
Hotel Development in NYC Hotel Development In
Hotel Development in NYC Hotel Development in NYC Famous Original New York City. Welcomes You. Always As 2019 winds down, New York City is closing in on the tenth consecutive year of record performance with more visitors from domestic and international markets – an expected 66.9 million visitors. Supporting this important increase in visitors is the parallel growth in the city’s hotel supply offering more choices, in more places around the city. The increase in overnight visitation from both business and, leisure travelers has supported tourism development in boroughs across the city and in established and emerging neighborhoods from the Bronx to Brooklyn, across Queens to Staten Island’s North Shore developments. New properties and exciting conversions and renovations in Manhattan are adding to the record increase in supply. The hotel pipeline in New York City continues to stand out in the US growth picture. With a range of ground up new buildings, restorations of historic buildings, and expansions, the outlook for new inventory supports the city’s Welcome. Always. message to visitors offering accommodations to suit all traveler needs and preferences. Over the past decade the city has attracted new brands, international properties, authentic neighborhood independents, and a wide-ranging collection of select service brands, business class hotels, lifestyle and boutique properties, and new luxury destinations. This report covers more than 250 hotels and projects, including many new and updated entries. Together they represent an estimated 21,300 plus additional rooms to the city’s already diverse inventory. At the current pace, the city is expected to top 144,000 rooms in active inventory by the end of 2021. -
Tulchinsky Gift Uses Finance Strategies to Move Medicine Forward
May 2017 milestones From left: Dr. Christopher Mason, Dr. Olivier Elemento, Igor Tulchinsky, Dr. Lewis Cantley ROGER TULLY Tulchinsky Gift Uses Finance Strategies to Move Medicine Forward A bold, new initiative made possible by a generous advanced financial algorithms and computational Board of Overseers. “We are very grateful to Igor gift from Overseer Igor Tulchinsky will enhance the methods, creating personalized disease and health Tulchinsky and WorldQuant, LLC for making this diagnosis and treatment of a variety of illnesses, models that will optimize treatment for patients. initiative possible.” including cancer, infectious The program will be co-directed Although the worlds of finance and medicine diseases and a range of “ This extremely creative by Dr. Christopher Mason, the may appear vastly different, both fields use “big neurological disorders. WorldQuant Foundation Research data” to discover important patterns, observes gift will accelerate and Mr. Tulchinsky’s gift of Scholar and associate professor Mr. Tulchinsky. He first became intrigued by the $5 million, made through his expand Weill Cornell of physiology and biophysics, and potential application of digital data to enhance company, WorldQuant, LLC, Medicine’s approach Dr. Olivier Elemento, the Walter biomedical research several years ago. In 2014, he will establish the WorldQuant to precision medicine, B. Wriston Research Scholar and established the WorldQuant Foundation Research Initiative for Quantitative providing new predictive associate professor of physiology Scholar -
PNI and Pathology: Translation, Treatment , and Prevention
16th Annual Meeting of The PsychoNeuroImmunology Research Society PNI and Pathology: Translation, Treatment , and Prevention June 3-6, 2009 Breckenridge, Colorado Beaver Run Resort and1 Conference Center Table of Contents Announcements & Donations Acknowledged……………………….. 2 PNIRS officers, council, and staff…………………………………...... 3 2010 Meeting……………………………………………………………. 3 General Information…………………………………………………..... 4 Cousins & Ader Awards……………………………………………….. 5 PNIRS Senior Faculty-Trainee Colloquium………………………..… 6 Program at a Glance…………………………………………………… 7 Detailed Program………………………………………………………. 8 Poster Session 1……………………………………………………..... 13 Poster Session 2……………………………………………………….. 17 Meeting Registrants……………………………………………………. 20 Announcements The winners of the officer elections (President-Elect, Secretary-Treasurer-Elect, and Scientific Council) will be announced at the Business Meeting on Friday, June 5th. The winners of the Norman Cousins Award Lecture and the Robert Ader New Investigator Award will be announced at the Closing Banquet on Saturday, June 6th. Acknowledgements Funding for the 2009 meeting was made possible in part by a conference grant (R13) from the National Cancer Institute. We also gratefully appreciate the support of Elsevier Inc. for sponsoring the Brain, Behavior, and Immunity Editorial Board luncheon and providing the complimentary copies of Brain, Behavior, and Immunity for non-member registrants. Special acknowledgements are extended to local organizers, Monika Fleshner and Mary Coussons-Read. Their dedication and commitment -
Hotel Development in NYC Hotel Development In
Hotel Development in NYC Hotel Development in NYC Welcome to New York. From the Bronx to Brooklyn, across Queens to Staten Island’s new North Shore, new hotel properties are joining the dynamic developments in Manhattan, as the hotel pipeline in New York City continues to outpace the US growth picture. With a range of ground up new buildings, restorations of historic buildings, and expansions, the outlook for new inventory supports the city’s Welcome. Always. message to visitors offering accommodations to suit all traveler needs and preferences. Over the past decade the city has attracted new brands, international properties, authentic neighborhood independents, and a wide-ranging collection of select service brands, business class hotels, lifestyle and boutique properties, and new luxury destinations. This report covers almost 200 hotels and projects, including almost a dozen new entries, that represent an additional 20,000 rooms to the city’s already diverse inventory. At the current pace, the city is expected to reach almost 139,000 rooms in active inventory by the end of 2021. For calendar year 2018, 18 new hotels opened with a total of approximately 3,400 rooms added to the City’s supply. Among the new openings are the upscale Park Terrace across from Bryant Park in midtown, the Aliz Hotel Times Square, the City’s first TownePlace Suites by Marriott, the Insignia Hotel in Brooklyn, a member of the Ascend Collection, Mr. C Seaport, a Leading Hotels of the World member, and The Assemblage John Street, a co-working space with extended stay accommodations in Lower Manhattan. -
Key Molecule May Tie Immune Response to Social Behavior
Spectrum | Autism Research News https://www.spectrumnews.org NEWS Key molecule may tie immune response to social behavior BY JESSICA WRIGHT 13 JULY 2016 Molecules that protect the body from infection may be needed for mice to socialize with their peers, according to a study published today in Nature1. This double duty could help safeguard the health of animals that live in close quarters. The findings bolster an emerging link between the immune system and conditions such as autism, says lead researcher Jonathan Kipnis, professor of neuroscience at the University of Virginia in Charlottesville. “Whether we like it or not, there is a piling up of evidence that the immune system has a major impact on brain function: The brain is not isolated from the rest of the body,” he says. The study pinpoints an immune molecule called interferon gamma as the key to this link. This molecule primes cells to attack intruders, and is ramped up during infections. The researchers found that without interferon gamma, signals in a brain region called the prefrontal cortex run rampant, and mice tend to be asocial. The prefrontal cortex is involved in social behavior, and is thought to be overactive in some people with autism2. “We show that an immune molecule directly controls brain circuits through neurons,” Kipnis says. The researchers presented preliminary results last year at the Society for Neuroscience annual meeting in Chicago. “[The results] suggest that the immune system and the central nervous system are extremely intertwined, and the function of both systems is critical for neuronal brain function,” says Carlos Pardo-Villamizar, associate professor of neurology and pathology at Johns Hopkins University in Baltimore, Maryland,.