THE UNIVERSITY OF BRITISH COLUMBIA
DEPARTMENT OF MEDICINE FACULTY OF MEDICINE
ANNUAL REPORT 2003
CONTENTS
INTRODUCTION ...... 3
MISSION STATEMENT...... 7
ORGANIZATION CHART ...... 9
UBC DEPARTMENT OF MEDICINE COMMITTEES...... 11 HOSPITAL HEADS, DIVISION HEADS AND PROGRAM DIRECTORS...... 13 COMMITTEE FOR APPOINTMENTS, REAPPOINTMENTS, PROMOTIONS AND TENURE ...... 15 TEACHING EFFECTIVENESS OFFICE...... 19 DIVISION REPORTS...... 21 ALLERGY & IMMUNOLOGY...... 23 CARDIOLOGY...... 27 CRITICAL CARE MEDICINE...... 41 DERMATOLOGY ...... 45 ENDOCRINOLOGY...... 49 GASTROENTEROLOGY...... 53 GENERAL INTERNAL MEDICINE ...... 57 GERIATRIC MEDICINE...... 61 HEMATOLOGY ...... 65 INFECTIOUS DISEASES ...... 69 MEDICAL ONCOLOGY...... 75 NEPHROLOGY ...... 79 NEUROLOGY ...... 83 PHYSICAL MEDICINE & REHABILITION ...... 97 RESPIRATORY MEDICINE...... 105 RHEUMATOLOGY...... 109 EDUCATIONAL PROGRAMS...... 113 CONTINUING MEDICAL EDUCATION PROGRAM ...... 115 HIV/AIDS RESEARCH PROGRAM ...... 117 GRADUATE STUDIES PROGRAM IN EXPERIMENTAL MEDICINE ...... 123 POSTGRADUATE EDUCATION PROGRAM...... 127 UNDERGRADUATE EDUCATION PROGRAM...... 129 PUBLICATIONS...... 131
GRANTS AND RESEARCH AWARDS...... 181
UBC Department of Medicine Page 1 Annual Report 2003
INTRODUCTION
Graydon S. Meneilly, MD, FRCPC Eric W. Hamber Professor & Head UBC Department of Medicine
I am pleased to provide this overview for the 2003 annual report on behalf of the UBC Department of Medicine. This report is also available on the internet at www.medicine.ubc.ca
Overview
The UBC Department of Medicine provides research, teaching and clinical services related to the nature, cause and prevention of adult diseases. We are the largest Department in the Faculty of Medicine and we consist of sixteen divisions: Allergy and Immunology, Cardiology, Critical Care, Dermatology, Endocrinology, Gastroenterology, Geriatric Medicine, Internal Medicine, Hematology, Infectious Diseases, Medical Oncology, Nephrology, Neurology, Physical Medicine and Rehabilitation, Respiratory Medicine and Rheumatology.
People
As you read through this document you encounter the many different aspects of the Department and the accomplishments that have been achieved over the past year. I would like to take this opportunity to highlight some of the many wonderful achievements of our members. Recruitment and retention are a large part of our business. We have appointed 16 Clinical Instructors, 6 Assistant Professors, 1 Clinical Professor, 2 Clinical Assistant Professors, 1 Associate Professor and 1 Clinical Associate Professor. We have promoted 7 Faculty members.
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Our faculty received 16 CIHR Scholarship/Scientist awards, 22 Michael Smith Scholarships/Scientist awards, 4 CRC Scientist awards and 9 Scholarship/Scientist awards from other peer reviewed agencies. These new hires will help us by expanding the research and teaching activities of our Divisions. The latter are particularly important as we approach the medical school expansion.
The Department extends its warmest congratulations to these outstanding individuals who received the following Departmental awards. The Fay R. Dirks Awards for Excellence in Teaching were awarded to Drs. Vinay K Dhingra (Critical Care) and Lindsay M. Lawson (Respiratory Medicine). The Martin M. Hoffman Awards for Excellence in Research were awarded to Drs. Doris J. Doudet (Neurology) and James A. Russell (Critical Care). The Donald M. Whitelaw Awards for Outstanding Grand Rounds were given to: Drs. Robert Reynolds & Mark Lysyshyn and Robert Levy. The Master Teacher Awards were given to Drs. Paul Champion (Respiratory Medicine) and Peter D. Pare (Respiratory Medicine).
In addition, members of the department were recognized by the faculty and other bodies for their excellence in teaching and research. Dr. George Hahn (Physical Medicine & Rehabilitation) was awarded the Duncan Murray Teaching Award for Teaching Excellence. Dr. Keith Humphries (Hematology) was given a UBC Killam Research Prize. Dr. Yu Tian Wang (Neurology) was named a Distinguished University Scholar. Drs. Tony Bai and Stephen Van Eeden (Respiratory Medicine) were awarded the UBC Izaak Walton Killam Memorial Faculty Research Fellowship. Drs. Urs Steinbrecher, Siegfried Erb and Eric Yoshida (Gastroenterology) were awarded the JF McCreary Prize from the UBC College of Health Disciplines. Dr. Clayton Smith (Hematology) was the recipient of a Canada Research Chair. Dr. Jerry Shapiro (Dermatology) was awarded the Galderma Dermatology Fellowship. Dr. John Schrader (Hematology) was admitted to Fellowship in the Royal Society of Canada. Dr Gordon Page (General Internal Medicine) was given the Canadian Association of Medical Education Award. Dr. John Esdaile (Rheumatology) was awarded a New Merck Frosst Canada Research Chair in Arthritis. Dr. Jon Stoessl (Neurology) and Dr. Peter Pare (Respiratory) received the Queen's Golden Jubilee Medal. Dr. Karen Gelmon (Medical Oncology) was given a YWCA Women of Distinction Award. Dr. Donald Carr (Gastroenterology) was awarded the AstraZeneca Teaching Award in Gastroenterology. Dr. David Bates, Professor Emeritus, was named to the Order of Canada.
One of the Department's most important strategic initiatives is the creation of the Academic Enhancement Endowment Fund and the Academic Enhancement Fund competition process. These awards are provided in an effort to ensure greater protected research time for individuals undertaking meritorious research. This fund has taken on greater importance as the endowment has grown and as the awards have increased. The recipients of the Academic Enhancement Endowment Fund awards in 2003 were Drs. Isabella Tai (Gastroenterology), Najib T. Ayas (Respiratory Medicine), Youwen Zhou (Dermatology), and Diane Lacaille (Rheumatology). Recipients are termed Departmental Scholars.
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Administration
The Department underwent full review in 2001. A number of concerns were raised by the reviewers. The Department has addressed many of the issues identified and is well positioned to take a leading role as an academic Department of Medicine in this country in the next decade.
Research
Once again the department was extremely successful in attracting research support. The department received $28,898,543 in peer reviewed grants and $12,584,372 in non-peer reviewed grants.
In order to move forward the Department has implemented a strategic planning process in Research and has appointed a new Associate Head Research at VGH and UBC, Dr. Doris Doudet. The culmination of these plans within the next academic year will give the Department a framework for success during my term as Head.
Education
Thanks to the efforts of Dr. Iain Mackie and Ms. Hazel Wilcox, our postgraduate program received full accreditation.
One of the most important roles of the Department in the next few years is stewardship as UBC embarks on its expansion of the medical school and its postgraduate programs. We are currently developing a departmental strategy to address this important issue. We have begun to appoint faculty members in Victoria and Prince George and we are sending residents to distributed sites.
Summary
In closing I would like to take this opportunity to once again acknowledge the contributions of all Faculty and Staff and to thank them for their hard work, outstanding achievements and dedication to the success of the Department of Medicine.
Sincerely,
Graydon S. Meneilly, MD, FRCPC Eric W. Hamber Professor & Head UBC Department of Medicine
UBC Department of Medicine Page 5 Annual Report 2003
MISSION STATEMENT
The Department of Medicine
University of British Columbia
We, the members of the Department of Medicine of the University of British Columbia, will work with all our partners to provide the highest possible standard of excellence in patient care, teaching and research. We will pursue this mission while emphasizing open communication and ethical behavior, and while recognizing that it is a privilege to provide responsible and innovative stewardship of human, financial and all other resources. We will always:
1. respect the dignity, individuality and needs of our patients, 2. strive to discover new knowledge that will advance state-of-the-art care, 3. ensure effective and innovative teaching of our students, 4. optimize our organization to promote both professional and personal fulfillment, 5. value the efforts and achievements of teams and individuals who work to face the challenges of modern medicine.
These activities will ensure the respect of our peer organizations and recognition as a world-class Department of Medicine.
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ORGANIZATION CHART
Dean UBC Faculty of Medicine
Head UBC Department of Medicine
Associate Heads, Heads & Directors of Divisions UBC Dept. of Medicine & Programs of UBC Heads, Hosp. Dept of Medicine Department of Medicine
Heads & Directors of Divisions & Programs of the Hospital Departments of Medicine
Members, Divisions & Programs of the Hospital Departments of Medicine
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UBC DEPARTMENT OF MEDICINE COMMITTEES
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HOSPITAL HEADS, DIVISION HEADS AND PROGRAM DIRECTORS
HOSPITAL HEADS
Vancouver Acute Dr. Graydon S. Meneilly, Head of Medicine
Providence Health Care Dr. James Russell, Head of Medicine
UBC DIVISION HEADS
Allergy & Immunology Dr. Robert Schellenberg, Head Cardiology Dr. Charles Kerr, Head Critical Care Medicine Dr. John Fenwick, Head Dermatology Dr. H Lui, Head Endocrinology & Metabolism Dr. David Thompson, Head Gastroenterology Dr. Urs Steinbrecher, Head General Internal Medicine Dr. Iain Mackie, Acting Head Geriatric Medicine Dr. Graydon Meneilly, Head Hematology/Bone Marrow Transplantation Dr. Michael Barnett, Head Infectious Diseases Dr. Neil Reiner, Head Medical Oncology Dr. Susan O'Reilly, Head Nephrology Dr. Eugene C. Cameron, Head Neurology Dr. Howard Feldman, Head Physical Medicine & Rehabilitation Dr. Theo Van Rijn, Head Respiratory Medicine Dr. John Fleetham, Head Rheumatology Dr. John Esdaile, Head
UBC DEPARTMENT OF MEDICINE EDUCATIONAL PROGRAM DIRECTORS
Continuing Medical Education Dr. Graydon S. Meneilly, Interim Director
Graduate Studies Program in Dr. Norman Wong, Director Experimental Medicine
HIV/AIDS Research Program Dr. Julio Montaner, Director
Postgraduate Education Program Dr. Iain Mackie, Director, Dr. Vinay Dhingra, Associate Director Undergraduate Education Program Dr. G. Stiver, Director
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COMMITTEE FOR APPOINTMENTS, REAPPOINTMENTS, PROMOTIONS AND TENURE
Chair: Dr. G.S. Meneilly, Professor Co-chair: Dr. J. Stoessl, Professor (Jan-July, 2003) Administrative Secretary: Ellen Wong
January – December: Dr. V. Bernstein, Clinical Professor Dr. L. Lawson, Clinical Professor Dr. R. Levy, Associate Professor Dr. H. Lui, Associate Professor Dr. K. Gelmon, Clinical Professor Dr. D. Ricci, Clinical Professor Dr. Y.T. Wang, Professor
January - June: Dr. N. Buskard, Clinical Professor Dr. J. Stoessl, Professor Dr. J. Oger, Professor Dr. J. Shepherd, Clinical Associate Professor
July - December: Dr. D. Doudet, Associate Professor Dr. J. Esdaile, Professor Dr. K. Humphries, Professor Dr. B. Koehler, Clinical Professor Dr. N. Murray, Clinical Professor
This dedicated group of committed Departmental members is charged with facilitating the career advancement of our members while upholding consistent and rigorous standards as set out by UBC. As usual, this Committee invested a great deal of thoughtful energy to support the additions and promotions listed below. We are all very proud of the following:
NEW APPOINTMENTS
Au, Sheila, Dermatology, Clinical Instructor Aymong, Eve, Cardiology, Clinical Assistant Professor Barnett, Michael, Hematology, Clinical Professor Brauer, Michael, Respiratory, Associate Member Byrne, Michael, Gastroenterology, Clinical Associate Professor
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Cherkasov, Artem, Infectious Diseases, Assistant Professor Chi, Kim, Medical Oncology, Assistant Professor Chia, Stephen, Medical Oncology, Assistant Professor Cook, Wendy, Geriatric Medicine, Clinical Instructor Coupland, Robert, Hematology, Associate Member Craig, Katherine, Critical Care, Clinical Instructor Crossman, Mark, Physical Medicine and Rehab, Clinical Instructor Cunningham, Kenneth, General Internal Medicine Dorscheid, Delbert, Critical Care, Assistant Professor Duke, Stephen, General Internal Medicine, Clinical Instructor Ervin, Frances, General Internal Medicine, Clinical Instructor Gill, John, Nephrology, Assistant Professor Hatala, Rose, General Internal Medicine, Clinical Associate Professor Holmes, Cheryl, General Internal Medicine, Clinical Instructor Jamal, Abeed, Nephrology, Clinical Instructor Johnson, Michelle, Endocrinology, Clinical Instructor Jung, Beverley, Nephrology, Clinical Instructor Khan, Nadia, General Internal Medicine, Clinical Instructor King, Kim, Geriatrics, Clinical Instructor Lam, Eric, Gastroenterology, Clinical Instructor Leavitt, Blair, Neurology, Associate Member Lertzman, Morley, Respiratory, Honorary Professor MacKay, Rhonda, General Internal Medicine, Clinical Instructor Madden, Kenneth, Geriatrics, Assistant Professor Marra, Fawziah, Infectious Diseases, Associate Member Martzke, Jeffrey, Neurology, Associate Member Mase, Robert, Endocrinology, Clinical Instructor McKeown, Martin, Clinical Associate Professor McLean, Grant, Medical Oncology, Clinical Professor Miller, William, Physical Medicine & Rehab, Associate Member Murphy, Colleen, Neurology, Clinical Instructor Patrick, David, Infectious Diseases, Associate Member Smith, Clayton, Hematology, Associate Professor Song, Kevin, Hematology, Clinical Instructor Tai, Charles, Neurology/GIM, Clinical Instructor Tai, Isabella, Gastroenterology, Assistant Professor Tan-Hogg, Wan, Respiratory, Honorary Professor Townson, Andrea, Physical Medicine & Rehab, Clinical Assistant Professor Tyndall, Mark, Infectious Diseases, Assistant Professor Yao, Jennifer, Physical Medicine & Rehab, Clinical Instructor
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PROMOTIONS
Professor:
Doudet, Doris, Neurology Duronio, Vincent, Respiratory
Associate Professor:
Av-Gay, Yossef, Infectious Diseases Dodek, Peter, Critical Care Palepu, Anita, General Internal Medicine
Clinical Professor:
Hoskins, Paul , Medical Oncology Shah, Amil, Medical Oncology Warshawski, Larry, Dermatology
Clinical Associate Professor:
Travlos, Andrew, Physical Medicine & Rehabilitation
Clinical Assistant Professor:
Isserow, Saul, Cardiology Dhingra, Vinay, Critical Care
Full-Time Reappointments:
Lacaille, Diane, Rheumatology Sandford, Andrew, Respiratory Spacey, Sian, Neurology Steiner, Theodore, Infectious Diseases Zhou, Youwen, Dermatology
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TEACHING EFFECTIVENESS OFFICE
Dr. James Busser Chair; Member, UBC Division of General Internal Medicine
Mrs. Jennifer Golinski Administrator; Undergraduate Education, UBC Department of Medicine Reports to:
Committee for Appointments, Reappointments, Promotions and Tenure
Functions:
1. Provides Faculty member with "Guidelines" for producing necessary back-up documentation to Teaching Dossier.
2. Meets with Faculty member to discuss necessary back-up documentation and process involved in review for promotion/tenure/reappointment.
3. Liaises with various program offices: Undergraduate, Postgraduate, Continuing Medical Education, Graduate Studies to obtain information regarding teaching effectiveness of candidate. Where necessary, requests additional peer review of teaching.
4. Reviews teaching dossier, back-up documentation, peer review and prepares draft report for Committee for Appointments, Reappointments, Promotions and Tenure.
5. Forwards draft report to Faculty member to ensure that important information has not been omitted.
6. Finalizes report and forwards to Committee for Appointments, Reappointments, Promotions and Tenure.
In the year 2002, the Teaching Effectiveness Committee prepared 20 letters on behalf of GFT and Clinical Faculty. Subsequent promotions for these faculty have included:
(2) Professor (3) Associate Professors (5) Full-Time Reappointments (2) Clinical Professors
In the year 2003 we met with another 19 faculty, and have prepared 19 letters to support their review and/or consideration of promotion.
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DIVISION REPORTS
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ALLERGY & IMMUNOLOGY
Dr. R. Robert Schellenberg Professor and Head
Faculty Members
Professor and Head Schellenberg, Dr. Robert SPH Clinical Associate Professor Mandl, Dr. Michael SPH Clinical Associate Professor Stark, Dr. Donald SPH Clinical Associate Professor Wong, Dr. HC George VA Clinical Instructor Kanani, Dr. Amin Vancouver
Divisional Overview
Our division is involved in providing clinical teaching in allergy and immunology at all levels. This includes major initiatives in patient education, CME programs for physicians, and elective rotations for residents and medical students. Despite not offering a training program at UBC, members are involved nationally in the nucleus committee of the Royal College as well as the examination committee for our subspecialty. This year we worked hard to host a highly successful international meeting (World Allergy Congress, Sept. 7-12, 2003) that show-cased Canadian contributions in the field of Allergy and Clinical Immunology.
Teaching
All members of the Division are actively involved in teaching students, residents, community physicians and lay persons.
Dr. Schellenberg provides a lecture to Medicine I students on the basic mechanisms of allergic inflammation as well as for the Pathology 521 course. All members actively participate in case- based subspecialty teaching seminars for Med III / IV students. All members provide individual office-based teaching of students who have chosen an elective rotation in the subspecialty. In addition, each member teaches in the Clinical Skills block for Med I students and conducts Bedside teaching sessions with Med II students. Major initiatives have been undertaken in community medical education to physicians, other health care professionals and to the lay public.
CME programs organized by Dr. George Wong through the auspices of the UBC Community Programs are given in various communities in British Columbia and the Northwest Territories.
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These have received excellent evaluations and are highly appreciated by physicians in outlying areas. Each member contributes to these programs.
Dr. Michael Mandl has continued to his asthma education program in outlying areas of BC. This initiative was initially established through the Health Transition Fund to raise awareness and specific information in management of asthma in communities in BC. This initiative has been recognized internationally and may be adopted by groups in the US.
Dr. George Wong has developed specific expertise in evaluation of complementary and alternative medicine practices and has presented a number of interesting papers on these aspects at meetings in the USA and Canada.
Research
Dr. Schellenberg is the Acting Vice President, Research for Providence Health Care and Assistant Dean, Research, UBC.
Dr. Mandl is continuing his studies on asthma education in communities throughout BC. This work entails delivery of education by qualified nurses spending time in these communities and evaluation of a number of health outcomes related to asthma. The American Lung Association has recognized the lack of any coordinated program in the USA and has invited Dr. Mandl to present his data and a demonstration of the software program developed to their education committee.
Dr. Amin Kanani is the principal investigator on a new grant submission for a study evaluating the quality of life and health outcome parameters of patients with primary immunodeficiency using two different dosing regimens of IVIG to determine optimal dosing requirements.
Dr. Wong is conducting studies assessing the use and potential harmful effects of herbal and Chinese medicines.
Dr. Schellenberg is continuing studies of the mechanisms of excessive airway narrowing in asthma with emphasis on the role of degradative enzyme effects on extracellular matrix components in the airway wall using laser capture microdissection and molecular biologic techniques.
Members of the Division are involved in clinical trials involving topical steroids, long-acting beta agonists, anti-IgE antibody therapy and different immunoglobulin products.
Clinical Services
All members are actively involved in providing clinical consultative services in Allergy and Immunology to the community. Dr. Mandl has outreach clinics in Dease Lake, Stewart, Hazelton, Bella Bella, Campbell River, Parksville and Bamfield. Dr. Stark provides outreach
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clinics in Prince George and Sechelt. He has been active with the hospitals in establishing protocols for the management of latex allergy in hospitals. Dr. Wong has had a specific interest in complimentary medicine practices and the potential harmful effects of specific treatments. Members provide consultative services at the two teaching hospitals.
National and International Initiatives
Drs. Stark and Schellenberg were co-chairs of the local arrangements committee for the World Allergy Congress (International Congress of Allergy and Clinical Immunology) held in Vancouver in September 2003. All members were involved in this large undertaking. Dr. Schellenberg was a member of the International Program Planning Committee for this meeting
Dr. Schellenberg is the president of the Canadian Society of Allergy and Clinical Immunology and is a member of the Royal College Examination Committee for this subspecialty.
Dr. Stark chairs the Nucleus Committee for Clinical Immunology and Allergy of the Royal College of Physicians and Surgeons of Canada
Dr. Stark and Dr. Schellenberg are members of the Board of Directors for the Canadian Foundation for Allergy and Clinical Immunology, a charitable organization of which Dr. Stark was the founder.
All members are actively involved in local, national and international committees dealing with their areas of interest.
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CARDIOLOGY
Dr. Charles R. Kerr Dr. Christopher E. Buller Professor & Head Clinical Professor & Head to Dec. 31, 2003 Jan. 1, 2004
Faculty Members
Professor Cairns, Dr. John VA Professor and Head Kerr, Dr. Charles SPH Professor Mancini, Dr. G B John VA Professor Rabkin, Dr. Simon VA Associate Professor Henning, Dr. Hartmut VA Assistant Professor Humphries, Dr. Karin SPH Clinical Professor Bernstein, Dr. Victoria VA Clinical Professor and Head Buller, Dr. Christopher SPH/VA Clinical Professor Dodek, Dr. Arthur SPH Clinical Professor Hamburger, Dr. Jaap SPH Clinical Professor Huckell, Dr. Victor VA Clinical Professor Penn, Dr. Ian VA Clinical Professor Ricci, Dr. Donald VA Clinical Associate Professor Carere, Dr. Ronald SPH Clinical Associate Professor Fung, Dr. Anthony VA Clinical Associate Professor Gin, Dr. Kenneth VA Clinical Associate Professor Ignaszewski, Dr. Andrew SPH Clinical Associate Professor Kiess, Dr. Marla SPH Clinical Associate Professor Macdonald, Dr. Ian SPH Clinical Associate Professor Thompson, Dr. Christopher SPH Clinical Associate Professor Webb, Dr. John SPH Clinical Associate Professor Yeung-Lai-Wah, Dr. John SPH
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Clinical Assistant Professor Aymong, Dr Eve SPH Clinical Assistant Professor Chan, Dr. Sammy SPH Clinical Assistant Professor Heilbron, Dr. Brett SPH Clinical Assistant Professor Isserow, Dr. Saul VA Clinical Assistant Professor Jue, Dr. John VA Clinical Assistant Professor Lee, Dr. Pui Kee VA Clinical Assistant Professor Straatman, Dr. Lynn SPH Clinical Instructor Munt, Dr. Bradley SPH Clinical Instructor Rabinowitz, Dr. Alan SPH Clinical Instructor Tung, Dr. Kei Kwong (Stanley) SPH Adjunct Professor Lear, Dr. Scott SPH Clinical Professor (Emeritus) Boone, Dr. John SPH Clinical Professor (Emeritus) Kavanagh-Gray, Dr. Doris Professor (Emeritus) Mizgala, Dr. Henry Vancouver Clinical Professor (Emeritus) Peretz, Dr. Dwight West Vancouver Clinical Professor (Emeritus) Shaw, Dr. Melville Vancouver Clinical Professor (Emeritus) Walters, Dr. Max
Divisional Overview
The Division of Cardiology consists of 33 active faculty including 27 clinical faculty and 6 full- time faculty distributed over two large tertiary programs at St. Paul’s Hospital and Vancouver Acute (included UBC site). This year (2003) marks the end of Dr. Charles Kerr’s remarkable tenure as Division Head, and latterly, as the Sauder Family Heart & Stroke Foundation Chair in Cardiology. Dr. Kerr has also fulfilled the role as Head, Division of Cardiology at St. Paul’s Hospital while Dr. Donald Ricci remained Division Head, Vancouver Acute.
The UBC Division of Cardiology enjoys expertise in a broad range of tertiary and quaternary cardiology sub-specialty services and programs. At both sites, the resulting operational complexities have led to the development of an organizational matrix that includes both Divisional and Departmental structures as well as operationally-based Cardiac Sciences program structures combining Cardiology and Cardiac Surgery. Sub-specialty programs and related streams of professional activity include:
• Consultative Cardiology (inpatient and outpatient) • Cardiac Risk Assessment and Atherosclerosis Regression • Cardiac Electrodiagnostics • Acute Coronary Care • Interventional Cardiology & Cardiac Catheterization • Cardiac Ultrasound • Heart Function • Cardiac Transplantation • Adult Congenital Heart Disease
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• Electrophysiology and Pacing • Cardiac Rehabilitation
Clinical trials and health outcomes research remain central to the Division’s research mission. The recruitment of a new Chair in Cardiology to assume responsibilities in January 2004 has provided an opportunity to seek new and focus existing resources for these areas. Robust programs in undergraduate and post-graduate teaching, a dynamic Royal College Cardiology Residency program, and a variety of highly regarded sub-specialty fellowship programs are supported.
Teaching
Undergraduate: Dr. Harry Henning is the Undergraduate Education Director. The Division provides a large share of the teaching of clinical examination skills within the Medical School, as well as lectures and problem-based tutorials within the Undergraduate Cardiac Sciences Block. To better standardize clinical teaching, Dr. Saul Isserow has undertaken the task of providing introductory instruction for the entire undergraduate class on the method of clinical examination. Elective rotations of medical students in ambulatory and CCU settings remain very popular amongst UBC students.
Postgraduate: Dr. Ken Gin is the Director of the Postgraduate Education Program in Cardiology. The academic component of the program continues to evolve and strengthen with introduction of several new initiatives including a dedicated Cardiovascular Epidemiology course (Drs. Karin Humphries and Arun Chockalingam), weekly bedside teaching sessions, weekly Interventional Cardiology and EP rounds, and a comprehensive Academic Half-Day program. The UBC program has provided leadership in the development of the WECREEP program which brings together Cardiology residents from throughout western Canada for annual lectures and practice examinations. Infrastructure support for our program has increased with a 0.5 FTE postgraduate secretary.
Through creative lobbying, coupled with donations from within the Division, Cardiology has secured new dedicated funding for postgraduate training. Consequently the core Cardiology residency program will grow to 12 trainees beginning July 2005, the largest number ever in the training program’s history. The challenge ahead is to train sufficient residents to meet the future cardiology manpower demands of British Columbia. This need has been highlighted in a peer- reviewed publication by Dr. Bradley Munt.
The Division has also been successful in creating and funding subspecialty training positions which are now offered in Interventional Cardiology, Cardiac Ultrasound and Cardiac Electrophysiology. Collectively these programs now enroll 11 fellows attracted from around the world (including Canada, the US, the UK and EU, Australasia, Asia, and the Middle East) to train in programs which have gained national and international recognition.
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Drs. Ian Penn and John Webb provide leadership for the fellowship programs in Interventional Cardiology at Vancouver Acute and St. Paul’s sites respectively. Eight 2-year trainees are engaged (3 to 5 per site) from a large and highly competitive local, national, and international pool of applicants. Both programs provide an extensive clinical experience in their first year with options for increasing research activity in the second. Numerous abstracts, manuscripts and several book chapters have been generated by the fellows in both programs. Weekly cross-site combined rounds provide a forum for fellow-led seminars and case presentations.
Continuing Medical Education:
Course & Convention Leadership
Mechanisms in Dyslipidemia; A Satellite Symposium John Mancini MD, Chair February 4, 2003
The Interventional Cardiology Whistler Course: Christopher Buller MD, Course Director Donald Ricci MD, Ian Penn MD, John Webb MD, Co-Directors February 6-9, 2003
The 13th Annual Interventional Whistler Course was accredited by the Canadian Cardiovascular Society and attended by over 90 participants. Course format emphasizes translation of invasive cardiac procedures to the practice of general and acute cardiology and internal medicine within BC’s regional and community hospitals. The faculty included all UBC-based interventional cardiologists supplemented by faculty from the University of Toronto and Harvard University.
27th Annual Internal Medicine Review for Primary Care Physicians Ian Macdonald MD, Course Director, May 5-9, 2003
This unique and limited registration course provides an intense learning experience for 20 physicians
The Montreal Live Interventional Cardiology Course Jaap Hamburger MD and John Webb MD, Co-Chairs, Vancouver Broadcast Program June 2003
Healthy Heart Cardiology Cruise & Fundraiser Course Coordinator: Ken Gin MD, August 2003
Inter-American Congress of Cardiology Charles Kerr MD, Chair of Scientific Program Committee, October 2003
Canadian Cardiovascular Congress 2003 Charles Kerr MD, Vice Chair, and Co-chair of Joint Organizing Committee, October 2003
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The Cardiorenal Connection Toronto; Canadian Cardiovascular Congress John Mancini MD, Chair, October 2003
This program in case-based learning was held at the 3rd Annual Canadian Cardiovascular Winter Symposium, Cancun, Mexico
Excellence in Interventional Cardiology V Ronald Carere MD, Course Co-Director, December 4-6, 2003
Run in conjunction with Co-Director Eric Cohen MD of Sunnybrook and Women’s College Hospital and Health Science Center in Toronto, the fifth annual Excellence in Interventional Cardiology course continues to attract leading interventional cardiologists from coast to coast. The course format emphasizes contemporary controversies and cost-effectiveness.
Research
Widespread emphasis on the development of evidenced-based medicine within cardiology means that large, multicenter clinical trials continue to provide a major area of research activity. In addition to numerous industry-funded projects, the Division is particularly active in peer reviewed clinical trials funded through agencies such as the Heart and Stroke Foundation of Canada and the National Heart, Lung, Blood Institute of the NIH. Both UBC hospital sites have gained an enviable reputation as worldwide leaders in strategic cardiovascular clinical trials. Several Division Members are now active at the executive steering committee level in NIH funded clinical trials. Dr. Mancini’s Cardiac Imaging Research Core Laboratory (CIRCL) has in parallel, become engaged in providing core analysis to several of these trials.
There are presently five independent clinical trial organizations within cardiology across the two sites who collectively employ approximately 23 management, clinical coordinator and support staff.
Outcomes and Health Services research primarily through the British Columbia Cardiac Registries (BCCR) and the Canadian Cardiovascular Outcomes Research Team (C-CORT) now engages many Division Members in various fields including access to care, health services geography, outcomes after PCI, valvular heart disease and surgery, cardio-renal interactions, etc. Outcomes research has prompted the development of new alliances with Members from the Divisions of Nephrology, Endocrinology, and Cardiac Surgery. The recruitment of a Cardiac Epidemiologist (Karin Humphries, PhD) to our Division has provided a key resource for our members.
Beyond clinical research within each of the core areas of cardiovascular medicine, the Divisions research activities reflect diverse interests including mechanisms of atherosclerosis, stem cell cardiomyogenesis, myocardial apoptosis, cardiac imaging, and medical device development. Individual members research activities are provided below.
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Dr. Eve Aymong was recruited from New York City, where she received a Masters degree in Patient Oriented Research and Biostatistics from Columbia University. While in New York, she worked at the Cardiovascular Research Foundation, primarily on trials of reperfusion strategies in acute myocardial infarction and at New York University on the currently enrolling SHOCK-2 trial. Her ongoing research includes outcomes evaluation of patients undergoing cardiac catheterization using the BC Cardiac Registry and continued collaboration on clinical trials with her colleagues in New York.
Dr. Christopher Buller is active in clinical trials and outcomes research. His interest in occluded coronary arteries and the ‘open artery hypothesis’ has led to his inclusion on the Executive Steering Committee, Operations Committee and Publications Committee of the NIH/NHLBI funded Open Artery Trial, an international multicenter clinical trial initiated in 1998 and scheduled for completion in 2007. Dr. Buller directs all aspects of the trial related to PCI (the experimental strategy), is Co-Director of the Core Angiographic Laboratory, and is Co- principal Investigator of the NIH/NHLBI funded angiographic substudy TOSCA-2.
Dr. Sammy Chan’s current research is focused on 2 areas. The first is on the role of endothelial function in the determination of prognosis in-patients with atherosclerosis. The second is on the type of exercise training that results in maximal benefits for patients enrolled in a cardiac rehab program.
Dr. Jaap Hamburger, in conjunction with colleagues at the iCAPTURE center, has coordinated a research program in cardiomyogenesis employing bone marrow stem cells. Both mouse and large animal models are employed.
Dr. Karin Humphries’ primary research focus is assessing the prevalence and determinants of secondary prevention in patients with cardiovascular disease. Other research interests include atrial fibrillation, both its natural history (CARAF) and prevention post-cardiac surgery (M- PAACS clinical trial).
Dr. John Mancini continues to direct the Cardiovascular Imaging Research Core Laboratory (CIRCL) which supports clinical studies by providing quantitative coronary angiography, quantitative carotid ultrasound, brachial endothelial dysfunction assessment and intravascular coronary ultrasound. Highlights in 2003 included: publication of the Atherosclerosis Reversal Clinic's experience in using flow mediated dilatation and carotid ultrasound to assess outcomes of cardiac rehabilitation patients, and presentation at the AHA 2003 Late Breaking Clinical Trials Sessions of the angiographic effects of cilastozol on stent restenosis.
The Cardiovascular Imaging Research Core Laboratory is a multi-modality imaging laboratory that provides objective, arms length analyses for single-and multi-centre clinical trials. The first iteration of this laboratory was created at the University of Michigan in the early 1980's and it is currently located in the Vancouver Hospital Research Pavilion. Eight FTE with ultra-specialized skills provide analyses of coronary angiograms, coronary intravascular ultrasounds, brachial
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ultrasounds (flow-mediated dilatation) and carotid ultrasound under the supervision of Dr. Mancini. In addition to supporting studies funded by the NIH, CIHR and pharmaceutical companies, the laboratory has functioned as a resource to collaborators within the Division of Cardiology, the Division of Respiratory Medicine and the Department of Pathology.
Dr. Graham C. Wong comes to VGH having completed a 2 year research fellowship with the TIMI Study Group in Boston Massachusetts. During this time he also completed a Master's Degree in Public Health from Harvard University. Dr. Wong is interested in myocardial perfusion following reperfusion therapy for acute coronary syndromes. He will be spearheading several research initiatives in acute coronary care in conjunction with the Centre for Clinical Epidemiology at Vancouver Hospital.
Clinical Sub-Programs
Acute Coronary Care:
St. Paul’s Hospital: Alan Rabinowitz MD, Medical Director
The Coronary Care Unit at St Paul's Hospital is an eleven-bed intensive care unit servicing inpatients and emergency room patients within St Paul's Hospital, as well as patients from around the Province of British Columbia and the Yukon requiring tertiary cardiac care. Each year, approximately 1000 patients are admitted to the unit, which is able to accommodate patients requiring mechanical ventilation, intra-aortic balloon pump support, invasive hemodynamic monitoring, temporary cardiac pacing and ventricular assist devices as a bridge to cardiac transplantation. This level of acuity is essential given the complexity of patients served by the Heart Centre at St Paul's Hospital, including patients with advanced heart failure, complex arrhythmias and congenital heart disease in addition to acute coronary syndromes and general cardiac conditions. The model is that of multidisciplinary care, with medical care provided in the unit and following transfer to a step down ward unit and subsequent discharge, by a medical team under the supervision of an attending cardiologist, and including cardiology fellows and trainees from a wide array of medical disciplines. Not only is the unit the hub of clinical activity within the Heart Centre, but also a focal point of teaching and research activity.
Vancouver Acute: Graham Wong MD, Medical Director
The VGH Coronary Care Unit is comprised of 14 critical care beds and 6 sub acute beds. The Unit continued its role as a tertiary care referral centre for critically ill cardiac patients in the GVRD and throughout BC. Approximately 2000 patients were admitted to the CCU from April 1, 2002 to March 31, 2003 from all of BC’s Health Authorities. 1391 of these admissions (71.4%) were considered emergent, and 558 (28.6%) were considered non-emergent. The average length of stay was 3.1 days, which was less than the expected LOS of 4.3 days. The CCU retains the capability to provide full hemodynamic and ventilatory support including the use of intraaortic balloon pumps.
UBC Department of Medicine Page 33 Annual Report 2003
The CCU was challenged by mandated staffing cutbacks in 2003 amounting to the loss of 2 full time equivalent nursing positions. However, improved patient flow-through and a commitment to excellent care by the nursing staff was instrumental in ensuring that a high level of care was maintained during this difficult time.
New initiatives put forth this year included implementation of a standardized Hypothermia Protocol for survivors of cardiac arrest.
The Unit remains committed to excellence in cardiovascular research. Two full time research nurses oversee a number of both inpatient and outpatient trials of cardiovascular therapeutics. The new CCU Director, Dr. Graham Wong, will spearhead several “in-house” research projects in collaboration with the Centre of Clinical Epidemiology and cardiac anaesthesia. The CCU welcomed Dr. Graham C. Wong, who took over from Dr. Ken Gin
Echocardiography:
St. Paul’s Hospital: Christopher Thompson MD, Medical Director
The Cardiac Echo Lab at St. Paul’s continues to expand clinical services. For fiscal 2003-2004 over 8,250 echoes including 400 transesophageal echoes were performed. The Lab remains active in the Cardiology training program providing experience to both core trainees and fellows receiving advanced training in echocardiography. In collaboration with Drs. Bowering and Klas of the Department of Anesthesiology the program for intraoperative tranesophageal echo during cardiac surgery has been formalized and expanded. Increasing support is being provided to interventional cardiology and electrophysiology for device placement (closure of atrial and ventricular septal defects, patent foramina ovale, and peri–prosthetic valve leaks) and cardiac ablation (atrial fibrillation, ventricular tachycardia, hypertrophic cardiomyopathy). Dr. Munt is an active member of national committees setting standards for performance and interpretation of echocardiograms and for cardiology manpower needs.
Vancouver Acute: John Jue MD, Medical Director
The VH echo Lab had another busy year almost matching the previous year high in number of studies despite the loss of one FTE technician (from 6 to 5) due to budget cutbacks. The lab performed a total of 11300 studies on 6 machines (60% outpatients, 40% inpatients) with approximately 800 transesophageal studies.
The database currently has 46,000 studies. Already one paper has been published from this database on nonagenarians. The current research efforts are focused on: • Tissue Doppler and BNP post MI • Handheld and contrast studies in ICU patients • Echo predictors of successful volume loading in ICU patients • Rosuvastatin in mild to moderate aortic stenosis.
UBC Department of Medicine Page 34 Annual Report 2003
The lab has at least one fellow a year to help spearhead these studies.
Interventional Cardiology & Cardiac Catheterization:
St Paul’s Hospital: John Webb MD, Medical Director Vancouver Acute: Ian Penn MD, Medical Director
Interventional Cardiology has been an area of strength within the Division of Cardiology for two decades. Year 2003 saw the return of Dr. Anthony Y. Fung (formerly CCU Director at VA) following a two-year Fellowship in Interventional Cardiology. Dr. Eve Aymong has been recruited to SPH following an Interventional Fellowship at Foothills Hospital, Calgary, Alberta and a Masters in Clinical Epidemiology from Columbia University. These recruits bring to eight the number of Interventional Cardiologists in the citywide program. Rotation of all Interventionalists between sites continues and has allowed the implementation of “best practices” from both sites.
Case volumes continue to grow at both sites with approximately 3,200 coronary interventions performed annually in the combined citywide program. Increasing use of primary PCI for treatment of acute myocardial infarction has had a major effect on the volume of out-of-hours activities at both sites. Our Interventional Cardiology programs in conjunction with the Coronary Care Units have spearheaded regionalized care for acute myocardial infarction. Through a clinical trial mechanism, in-field triage of acute myocardial infarction patients now occurs within major segments of the Vancouver Coastal and Fraser Health Regions. This allows patients to be transported directly for timely primary PCI at SPH or VA on a ‘24/7’ basis.
St. Paul’s Hospital Cardiac Catheterization Laboratory has become a national leader in complex catheter-based procedures for treatment of atrial septal defects, patent foramen ovale, patent ductus arteriosus, perivalvular leaks, valvular stenosis and adult congenital heart disease. This specialization has required particularly close collaboration with echocardiographers before and during procedures for case selection and real-time procedural navigation and assessment.
Vancouver Acute has established activity in extra-coronary vascular interventions with initial emphasis in renovascular disease. New relationships with other medical and surgical specialties are being developed (including nephrology, vascular surgery, neurosurgery and neuroradiology). These relationships are an attempt to overcome the limitations of traditional specialty boundaries when catheter-based treatment of atherosclerotic lesions in divergent vascular territories is required. Strategic recruitment of an individual trained in carotid and peripheral vascular intervention to the Division of Cardiology is planned for 2004 or 2005.
Both sites have developed novel programs for vascular brachytherapy and interventions for hypertrophic cardiomyopathy.
UBC Department of Medicine Page 35 Annual Report 2003
Electrophysiology:
St. Paul’s Hospital: John Yeung MD, Director of Electrophysiology Laboratory
The Cardiac Electrophysiology (EP) program is co-directed by Drs. John A. Yeung-Lai-Wah (Interventional Electrophysiology) and Charles R. Kerr (pacemakers and ICDs). The service is provided by three electrophysiologists, with Dr. Stanley K. Tung being the third member of the team. There are two training fellows in the program.
Being a quaternary referral center, the program is very busy and is in the forefront of the field. In the lab, where an equivalent of four days are dedicated to interventional EP each week, 513 ablations and 142 diagnostic procedures were performed in 2003. Both adult and paediatric populations were served. Ablation procedures continue to increase in complexity and are now applied to patients with a range of underlying heart diseases including ischemic heart disease, cardiomyopathy, and children and adults with congenital heart disease. The spectrum of arrhythmias treated now includes atrial fibrillation/flutter, atrial ventricular re-entrant tachycardias, AV nodal re-entrant tachycardias, ectopic atrial tachycardias, and ventricular tachycardia. New techniques are being developed to cure atrial fibrillation, which has been a primary focus of research in recent years. We utilize state-of-the-art technology for 3- dimensional mapping (ESI Ensite and NAV-X systems, Endocardial Solutions Inc.) of complex tachycardias in atrial and ventricular chambers. During the past two years, we have been designated the Center of Excellence for Endocardial Solutions, serving the northwest region of the American continent with regards to education and research. Last year, 460 pacemakers and 182 ICDs were implanted. Dual-site atrial pacing for the prevention of atrial fibrillation and bi- ventricular pacing using endocardial or epicardial approaches to improve left ventricular function have been among innovations in these fields.
Cardiac Rehabilitation, Prevention, and Risk Factor Management:
St. Paul’s Hospital: Andy Ignaszewski MD, Medical Director
During 2003 the Healthy Heart Program enjoyed a very productive year with regard to clinical, academic and research activities, which are summarized below.
Clinical There were close to 400 patients referred through the Cardiac Rehabilitation Program and 800 patients referred to the Lipid Clinic in 2003 for a total visits to both clinics (including follow-ups) exceeding 16,000. Services in the program continue to evolve with the modification of the existing services to include “risk reduction clinic” which encompasses both primary and secondary prevention. The clinical part of the program continues to receive good evaluation from rotations for Cardiology Fellows, Endocrinology and Pathology residents and the new rotation for Family Practice residents.
UBC Department of Medicine Page 36 Annual Report 2003
Academic At present there is one Ph.D. and four masters students and one Post-Doctoral Fellow training in the Healthy Heart Program with close linkages to University of B.C. and Simon Fraser University. Currently the program supports numerous internal studies, clinical trials and three peer review grants.
Vancouver Acute: Saul Isserow MD, Medical Director
The Centre for Cardiac Rehabilitation and Risk Factor Management is a hospital-based Cardiac Rehabilitation program. The Centre has both close ties and medical staff integration with the St. Paul’s based Healthy Heart Program. We currently have approximately 240 patients enrolled in both the Regular and Maintenance components of the program. We accept referrals from both within the hospital and from outside physicians. The staff is highly motivated, dedicated and knowledgeable and the high degree of appreciation felt for the program by past and present participants was most demonstrably manifested by the fact that we raised over $70,000 at our recent annual fund-raiser.
In the last eighteen months, we have further developed the program to include the addition of a Staff Psychiatrist to help direct us in the oft ignored psycho-social impact of CV disease on our patients and their families.
The annual funding from the hospital of approximately $80,000 accounts for +/- 30% of expenses, the remainder of which is derived from patient fees. External funding for those who find the monthly fees unaffordable is available. The program is highly regarded by physicians and patients alike and we are justifiably proud of the multi-disciplinary and all encompassing approach we have fostered towards patient cardiac care. As a model of integration across hospital sites and mutual respect and support, the Centre’s association with the St. Paul’s Hospital based Healthy Heart program is a model worth expanding upon.
Atherosclerosis Regression Clinic:
St. Paul’s Hospital: Sammy Chan MD, Medical Director
Ischemic coronary events are now clearly linked to progression of atherothrombotic coronary lesions. Whereas most physicians treat patients with coronary artery disease to a predefined serum cholesterol target, mounting clinical evidence suggests more aggressive therapy titrated specifically to arrest or regress atherosclerosis is superior. The Atherosclerosis Regression Clinic led by Dr. Sammy Chan and facilitated by Drs. Mancini, Ignaszewski and Frohlich is developing and evaluating this approach. The clinic employs advanced biochemical evaluation of lipids and lipoproteins, dynamic measures of endothelial function, and non-invasive measurement of atherosclerosis.
UBC Department of Medicine Page 37 Annual Report 2003
Heart Function Clinic / Cardiac Transplantation:
St. Paul’s Hospital: Andy Ignaszewski MD, Medical Director
Heart Function and Heart Transplant programs in 2003 enjoyed record popularity. There were 94 patients referred to the Pre-Heart Transplant Assessment for a total of 682 visits in 2003. We performed the first two ventricular assist device implantations in western Canada – one extracorporeal Thoratec and one intracorporeal HeartMate. We successfully performed 18 heart transplantations. We successfully implemented tailored medical therapy system for advanced heart failure and started using novel marker NT-pro BNP for assessment and stratification of risk for advanced heart failure. Heart Function Clinic has come of age with a total of close to 250 patients and 2000 follow-up visits to the clinic, which now operates four half-days a week. Those who have significantly improved and we believe are stable are now transferred to the newly created “Maintenance Clinic” where their ongoing well-being is monitored. Post Transplant Clinic has been busy with 584 visits in 2003. Post transplant patients are now managed according to new consensus guidelines with decreased utilization of biopsy, coronary angiography with increased emphasis of control of cardiovascular risk factors and non-invasive assessment of graft atherosclerosis.
Academic: Heart Failure/Heart Transplant program is now part of the mandatory training for cardiology fellows, as well as for trainees in cardiovascular and thoracic surgery. It is increasingly attended by senior medical residents and family practice residents. The clinic and the staff working there formed part of first province-wide collaborative on the management of congestive heart failure where principles of “shared care” between nursing staff, primary care physicians and specialists are being worked up in the new reality of chronic disease management.
Research: The program participated in several clinical research protocols for advanced heart failure and heart transplantation. A total of 6 papers and 4 abstracts were written in 2003.
Pacific Adult Congenital Heart (PACH) Clinic:
St. Paul’s Hospital: Marla Kiess MD, Medical Director
The PACH (Pacific Adult Congenital Heart) Clinic at St. Paul’s Hospital is the only adult congenital heart clinic in BC. The number of individuals reaching adulthood with ACH disease has grown dramatically (5-10% per yr). At present, the clinic follows 1400 patients (35% increase in the last year). Currently, the waiting list is >3 months.
Adults with ACH disease have complex medical, education and psychosocial problems, which are best addressed by a multidisciplinary approach. At the present time, we have a Program Director, (Dr. Marla Kiess) who allocates 30% of her time to the Clinic. There are 2 pediatric and 1 adult cardiologist who see patients at the Clinic on a part-time basis. Dr. Marla Kiess and Doreen Fofonoff are members of the Board of Directors of the Canadian Adult Congenital Heart
UBC Department of Medicine Page 38 Annual Report 2003
Network. Recruitment is urgent (the clinic has difficulty meeting the current demands with existing resources).
We have a transition clinic 2-3 times a year to help patients and their families move from the familiar environment at BC Children’s Hospital to the very different environment of an adult hospital. PACH patients, physicians, the CNS, social worker and psychologist are all involved in these very successful evenings. We have become world leaders in this area.
Selected Lectures and Presentations
Dr. Eve Aymong
Impact of absolute and relative ST segment resolution after primary PCI: Methodologic considerations and impact of therapies (CADILLAC). TransCatheter Therapeutics, Washington, D.C, September 2003 - N-Acetylcystine: analytical review of all the randomized trials.
Dr. Christopher Buller
Renal Vascular Disease; Prevalence & Relevance to Cardiac Populations, Cardiology Grand Rounds, University of Alberta, Edmonton, Alberta, February, 2003 Renal Artery Stenosis: Prevalence and Implications in Cardiac Populations, ACC Lake Louise, March, 2003 Suspecting and Screening for Renovascular Disease?, Transcatheter Therapeutics Conference, Washington, DC, September, 2003. Long-Term Results after CTO Recanalization – Who Benefits?, TCT, Washington, DC, September, 2003. Mechanical Intervention in STEMI: What is the Best Use of Limited Resources, New Concepts in ACS: Beyond 2000, Canadian Cardiovascular Congress, Toronto, October, 2003. The Role of Mechanical Intervention in Acute Coronary Syndrome, Inter-American Congress of Cardiology Lecturer, Congress of Cardiology, Canadian Cardiovascular Congress, Toronto, October, 2003 Diagnosis and Treatment of Renal Artery Stenosis, Excellence in Interventional Cardiology, November, 2003
Dr. Brett Heilbron
Coronary Disease and Prevention in 2003, 38th Annual Post Graduate Review in Family Medicine, Renaissance Vancouver Hotel Harbourside, Vancouver, Feb 2003 ABPM and Early Morning Risks, Williams Lake, Mar 2003 Update in the Treatment of Hypertension, GP’s, Surrey Memorial Hospital, Mar 2003 Keynote Speaker, 27th Annual Internal Medicine Review for Primary Care Physicians – St- Paul’s Hospital, Treatment of Hypertension – HALLHAT, GP’s, Vancouver, May 2003 Chair, ECG Workshop, St. Paul’s Emergency Conference, GP’s, Whistler, Sept 2003
UBC Department of Medicine Page 39 Annual Report 2003
Update in Cardioprotection for General Practitioners, Vancouver, Nov 2003 Cardiovascular Disease and Erectile Dysfunction for General Practitioners, Langley, Dec 2003
Dr. Marla Kiess
Fofonoff, D. Asking the tough questions: Panel discussion for youth. Growing Up With Heart Disease: A Collaborative Conference for Families and Professionals by Families and Professionals, Building Bridges, Sharing the Expertise, Vancouver, BC, September 20-21 2003 [panel facilitator]. Chair, Symposium on "Managing Heart Disease in Pregnancy", Interamerican Congress of Cardiology, Toronto, 2003 Keynote speaker, "Heart Disease in the Elderly", "Acute Coronary Syndromes", and "Current Management of Congestive Heart Failure", Yukon Medical Association Meetings, 2003.
Dr. John Webb
Direct PCI for AMI - The 13th Annual Interventional Whistler Course Feb 2003 Excellence in Interventional Cardiology Workshop Dec 2003 Direct PCI for AMI, Lions Gate Hospital The WEST Trial, Mt. St. Joseph’s Hospital The WEST Trial, Richmond General Hospital Direct PCI for AMI, Peace Arch Hospital Interventional Cardiology, Royal Columbian Hospital journal club Interventional Cardiology, Vancouver General Hospital Cardiac combined rounds Interventional Cardiology, Chicago, American Heart Association
Special Honours and Awards
Dr. Christopher Buller, Governor, American College of Cardiology Dr. Christopher Buller, Founding Member, Academy of Transcatheter Therapeutics Dr. Arthur Dodek, Chair, Ethical Standards and Conduct Review Committee Dr. Arthur Dodek, Secretary/Treasurer, College of Physicians and Surgeons of BC Dr. Ken Gin: The Shelley Naiman Award for Clinical Teacher of the Year Dr. Brett Heilbron, Graeme Copland Clinician Teacher Award Dr. A.P. Ignaszewski: St. Paul’s Hospital Family Practice and Royal College Residents of 2002-2003 Teacher of the Year Award Dr. A.P. Ignaszewski: UBC Roche Oncology Award for Excellence in Clinical Teaching Skills 2002-2003 Dr. M. C. Kiess, President, Canadian Nuclear Cardiology Society Dr. M. C. Kiess, Member, Board of Directors, American Society of Nuclear Cardiology Dr. M. C. Kiess, Member, Board of Directors, Canadian Adult Congenital Heart Network Dr. Ian Macdonald: The Howard B. Stein Master Teacher Award for 2002-2003 Dr. Ian Macdonald: Chair, Pharmacy and Therapeutics Committee, Providence Health Care
UBC Department of Medicine Page 40 Annual Report 2003
CRITICAL CARE MEDICINE
Dr. John C. Fenwick Clinical Assistant Professor & Head
Faculty Members
Professor Russell, Dr. James SPH Professor Walley, Dr. Keith SPH Associate Professor Dodek, Dr. Peter SPH Assistant Professor Dorscheid, Dr. Delbert SPH Clinical Associate Professor Tsang, Dr. John SPH Clinical Assistant Professor Chittock, Dr. Dean VA Clinical Assistant Professor Dhingra, Dr. Vinay VA Clinical Assistant Professor and Head Fenwick, Dr. John VA Clinical Assistant Professor Forrest, Dr. David VA Clinical Assistant Professor Grant, Dr. Gregory SPH Clinical Assistant Professor Keenan, Dr. Sean SPH Clinical Assistant Professor Ronco, Dr. Juan VA Clinical Instructor Craig, Dr. Katherine VA Visiting Scientist Wattanathum, Dr. Anan SPH
Divisional Overview
The UBC Division of Critical Care Medicine is multidisciplinary in structure, with 13 faculty members, all qualified critical care specialists from Medicine, Surgery and Anaesthesia backgrounds participating in patient care at St. Paul’s, Royal Columbian and Vancouver Hospital. The two-year Critical Care Medicine subspecialty training program is fully accredited and accepts two trainees per year. The Research Program in Critical Care Medicine is comprehensive, spanning from molecular and cellular biology through large animal models to clinical research in critically ill adults. The basic science research program is based in the Cardiopulmonary Laboratories at St. Paul’s Hospital and the Jack Bell Research Institute at Vancouver Hospital. The clinical research program is focused in the intensive care units of St. Paul’s and Vancouver Hospital.
UBC Department of Medicine Page 41 Annual Report 2003
Teaching
The University of British Columbia Adult Critical Care Medicine Training Program, under the direction of Dr. Juan Ronco, continued at the British Columbia Children’s, St. Paul’s and Vancouver Hospitals. In 2003 there were 5 trainees in the Adult Critical Care Medicine Fellowship Training Program. The ICU rotations for specialty residents from Medicine, Anaesthesia and Surgery continued to be highly rated at both St. Paul’s and Vancouver Hospital. Under the direction of Dr.Vinay Dhingra the Division held its first SCCM Critical Care Support Course for the core medical residents.
Research
The Research Program in Critical Care Medicine is comprehensive, spanning from molecular and cellular biology through large animal models to clinical research in critically ill adults. The basic science research program is based in the Cardiopulmonary Laboratories at St. Paul’s Hospital and the Jack Bell Research Institute at Vancouver Hospital. The clinical research program is focused in the intensive care units of St. Paul’s and Vancouver Hospitals.
The basic science research program continues to investigate corticosteroid and ischemia/reperfusion induced airway epithelial cell apoptosis (Dr. Dorscheid), endothelins and the mechanism of hypoxemia in acute pulmonary embolism (Dr.Tsang), the molecular and cellular biology of leukocyte induced myocardial dysfunction in septic shock (Dr. Walley) and immunomodulation in the treatment of sepsis and acute lung injury (Drs. Russell and Walley).
The clinical research program remains strong at St. Paul’s and Vancouver Hospital with studies on the role of genotype on phenotype in sepsis and systemic inflammatory states (Drs. Walley and Russell), genetics of ARDS (Dr. Russell), glucose control and outcomes in the critically ill (Drs. Dhingra, Chittock, Ronco, Dodek and Fenwick), clinical studies of therapeutic interventions for viral infections (Dr. Grant), recognition and treatment of delirium in the ICU (Dr. Chittock), the variation and determinants of processes, outcomes and costs of critical care in BC (Drs. Dodek and Keenan), treatment of catheter related bloodstream infections (Drs. Ronco and Dhingra), role of non-invasive ventilation in critical illness (Dr. Keenan), effect of sedation and agitation on duration of mechanical ventilation (Dr. Chittock), adrenal function in sepsis (Drs. Fenwick, Chittock and Ronco), post cardiac arrest decision making (Dr. Forrest), ventilator associated pneumonia (Dr. Dodek), vasopressin in septic shock (Drs. Russell, Walley, Chittock and Ronco) and blood transfusion and cerebral oxygenation in head injury (Drs. Chittock and Fenwick).
Clinical Services
Dr. Katherine Craig, an intensivist with specialty certification in Internal Medicine joined the faculty at Vancouver Hospital. Dr. Craig’s recruitment will significantly strengthen the
UBC Department of Medicine Page 42 Annual Report 2003
Division’s clinical and academic programs. Dr. Greg Grant was appointed the Acting Medical Director of the St. Paul’s Hospital Intensive Care Unit. The ICU’s at St. Paul’s and Vancouver Hospital continued to experience an increase in occupancy and workload with over 1600 admissions at the two sites. Collaborative strategies to improve funding for critical care services at both sites continue to be developed. The ICU at Vancouver Hospital will see an expansion to 28 beds in 2004.
Future Directions
In 2004, under the direction of Dr. Dean Chittock, the Division will hold the first annual Canadian Critical Care Conference at Whistler, BC. Under the direction of Dr. Vinay Dhingra, the Division will be implementing the SCCM Fundamentals in Critical Care Medicine Support Course as part of the core residency training program. It is anticipated that the SCCM course will, in the future, become a successful CME activity within the Department of Medicine, attracting critical care providers from around the province. Drs. Ronco and Dingra, in collaboration with the Center for Excellence in Surgical Education and Innovation, have begun to develop a simulator model for the teaching of technical and patient management skills to critical care trainees. The Division continues to develop a strategy to strengthen its University Multidisciplinary Program.
Special Honours and Awards
Dr. Dean Chittock was an invited speaker at the Toronto Critical Care Medicine Symposium, Toronto, Ontario and the Advances in Respiratory and Critical Care Medicine Conference, Whistler, BC.
Dr. Vinay Dhinga was promoted to Clinical Assistant Professor and was the recipient of the Fay R. Dirks Award for Excellence in Teaching. Dr. Dhingra was an invited speaker at the Malaysian Conference on Respiratory and Critical Care Medicine, Kuala Lampur, Malasia, and the UBC Advances in Internal Medicine Conference, Vancouver, BC.
Dr. Peter Dodek was an invited speaker at the Toronto Critical Care Medicine Symposium, Toronto, Ontario, the Canadian Collaborative for Improvement of Safety and Care in Intensive Care, Toronto, Ontario, the Rocky Mountain Critical Care Conference, Vernon, BC, and the Canadian Society for Clinical Nutrition Conference, Vancouver, BC.
Dr. Del Dorscheid was an invited speaker at the Advances in Respiratory and Critical Care Medicine Conference, Whistler, BC, and the American Thoracic Society Meeting, Seattle, Washington.
Dr. Sean Keenan was an invited speaker at the Advances in Respiratory and Critical Care Medicine Conference, Whistler, BC and the American College of Chest Physicians Annual Meeting, Orlando, Florida.
UBC Department of Medicine Page 43 Annual Report 2003
Dr. Juan Ronco was an invited speaker at the Advances in Respiratory and Critical Care Medicine Conference, Whistler, BC.
Dr. Jim Russell was the recipient of the UBC Martin F. Hoffman Award for Excellence in Research and was an invited speaker at the Toronto Critical Care Medicine Symposium, Toronto, Ontario, the Society of Critical Care Medicine Annual Conference, San Antonio, Texas, the Rocky Mountain Critical Care Conference, Vernon, BC, the European Society of Intensive Care Medicine Annual Meeting, Amsterdam, Netherlands, and served as the Acute Lung Injury Session Co-chair, the Margaux Conference in Critical Care, Lisbon, Portugal.
Dr. Keith Walley received a Distinguished Scholar Award from the Michael Smith Foundation.
UBC Department of Medicine Page 44 Annual Report 2003
DERMATOLOGY
Dr. Harvey Lui Professor & Head
Faculty Members
Professor Ho, Dr. Vincent VA Professor and Head Lui, Dr. Harvey VA Professor McLean, Dr. David VA Professor Rivers, Dr. Jason VA Associate Professor Dutz, Dr. Jan VA Associate Professor Kitson, Dr. C. VA Associate Professor Li, Dr. Gang VA Assistant Professor Zhou, Dr. Youwen VA Clinical Professor Carruthers, Dr. Alastair VA Clinical Professor Shapiro, Dr. Jerry VA Clinical Professor Warshawski, Dr. Laurence VA Clinical Associate Professor Conklin, Dr. Robert VA Clinical Associate Professor Kunimoto, Dr. Brian VA Clinical Associate Professor Ongley, Dr. Roberta VA Clinical Associate Professor Schlappner, Dr. Otto SPH Clinical Assistant Professor Gregory, Dr. Brian VA Clinical Assistant Professor Kenny, Dr. Patrick Royal Jubilee Clinical Assistant Professor Morton, Dr. Charles VA Clinical Assistant Professor Prihoda, Dr. Marie VA Clinical Assistant Professor Thomas, Dr. D. Richard VA Clinical Assistant Professor Tuyp, Dr. Evert VA Clinical Assistant Professor Zloty, Dr. David VA Clinical Instructor Amiss, Dr. John Victoria Clinical Instructor Au, Dr. Sheila SPH Clinical Instructor Davis, Dr. Anne VA Clinical Instructor Hong, Dr. Chih-ho SPH Clinical Instructor Shokravi, Dr. Mohammad North Vancouver Honorary Professor Nguyen, Dr. Nhiem Richmond Associate Member Ball, Dr. Nigel VA
UBC Department of Medicine Page 45 Annual Report 2003
Associate Member Crawford, Dr. Richard SPH Associate Member Gallagher, Dr. Richard Vancouver Associate Member Martinka, Dr. Magdalena VA Associate Member Prendiville, Dr. Juliette BCCH Associate Member Zeng, Dr. Haishan BCCA Adjunct Professor Thewalt, Dr. Jenifer Burnaby Visiting Scientist Ou, Dr. Hesheng Vancouver Clinical Professor (Emeritus) Maddin, Dr. Stuart VA Clinical Professor (Emeritus) McLeod, Dr. W. SPH
Divisional Overview
2003 was an incredibly busy year for the Division of Dermatology. One major highlight was a fundraising drive that culminated in a $500,000 grant from the VGH & UBC Hospital Foundation to support dermatology services and research at the Skin Care Centre. Significant donations were also received from several patients and trainee alumni. Advanced planning got underway in 2003 for the medical school expansion that becomes a reality in September 2004. The Division continues to provide a comprehensive academic program with trainees across the entire spectrum as well as independent research laboratories dedicated to skin cancer, hair biology, photomedicine/optics, immunology, and genomics. Our current program is based at Vancouver General Hospital, St. Paul’s Hospital, BC Cancer Agency, and BC’s Children’s Hospital, and we look forward to closer relationships with our academic colleagues in Victoria, Prince George, and the rest of BC.
Teaching
Undergraduate: Dr. Jerry Shapiro, Director. One of the key challenges facing our undergraduate program is the provision of one-on-one teaching preceptorships for all 3rd year medical students in the expanded medical school. Our current 3rd year clerkship course (DERM 430) is mandatory for all students, and fortunately our dermatologist colleagues in Victoria and Prince George have agreed to provide these valuable clinical experiences within their own practices. Pilot clerkships for Dermatology in Victoria have been formally planned for early 2004. The 2nd Year Integument Course (FMED 422) continues to receive accolades from students, especially in terms of the customized learning resources available on the web.
Postgraduate: Dr. Jason Rivers, Director. The Dermatology Residency Program remains highly competitive and we continue to have the good fortune and challenge of selecting from amongst many of the top graduating medical students in Canada. The full 5-year resident training program in Dermatology is usually entered directly from medical school, but from time to time we have been able to secure funding for re-entry positions, as was the case for one new position in 2003. As with many other medical specialties, there is a serious shortage of dermatologists in Canada, and the Division of Dermatology is working closely with the Department of Medicine and the Postgraduate Dean’s Office to increase the number of training slots to 3 per year once our medical school is fully expanded over the next decade.
UBC Department of Medicine Page 46 Annual Report 2003
This year the Division was successful in recruiting one of our newest dermatology graduates, Dr. Sheila Au, to join our teaching staff at St. Paul’s Hospital. Dr. Au holds dual certification in Dermatology and Pediatrics. In 2003, we also bade farewell to two other residents: Dr. Gabrielle Weichert and Dr. Shane Silver, who will be practicing in Nanaimo and Winnipeg respectively.
In addition to our 8 dermatology residents, we also hosted clinical fellows in dermatologic surgery, photomedicine/lasers, hair, and dermatopathology from the US, Saudi Arabia, and China.
Experimental Medicine: 2003 marked the first year that the Division of Dermatology has had as many graduate students as residents and clinical fellows. All graduate students were enrolled in the department’s Experimental Program, and were supervised by the Skin Biology Lab, the Photomedicine/Optics Lab, Laboratory of Predictive Medicine and Therapy, and Immunology Lab.
Continuing Medical Education: Attendance at our Royal College MAINCERT events is very healthy with regular activities including our Weekly Grand Rounds (which feature onsite patient presentations), Community Journal Clubs, and Dermatology Research Day. CME courses directly sponsored by the Division of Dermatology include: • Spring Dermatology Update for Family Physicians (May 30-31, 2003). Course Director: Dr. Brian Kunimoto
• Dermatology Update 2003 (November 5-9, 2003) Our Division members also continue to be in high demand at Family Practice and Internal Medicine CME courses.
Research
In 2003, the UBC Dermatology Research Day (March 8, 2003) coincided with the university- wide Research Awareness Week. This event has grown each year and now has to be held off-site at a special venue to accommodate all the presenters and attendees. The integration of multiple health profession groups (medical, nursing) and trainees at different levels appears to be a major strength of this event.
In recognition of the multiple groups at UBC working on skin cancer, a new Skin Cancer Research Group was inaugurated in September 2003 with the goal of coordinating research activities and fundraising. The vision is to create a world-class, comprehensive centre of excellence for skin cancer at UBC in partnership with the BC Cancer Agency, the Vancouver Coastal Health Research Institute, and the Provincial Health Services Authority.
UBC Dermatology investigators were very competitive at the national level with multiple research grant awards from the Canadian Institutes of Health Research, National Cancer Institute
UBC Department of Medicine Page 47 Annual Report 2003
of Canada, and the Canadian Dermatology Foundation. The Clinical Trials Unit undertook novel trials for biologic therapy of psoriasis as well as photodynamic therapy of cancer and androgenetic alopecia.
Clinical Services
The demand for dermatologic services continues unabated, and all of our teaching clinics operated at over capacity throughout the year. 2003 also marked the formal creation of a combined Dermatology Call Group within the Vancouver Coastal Health Authority. Faculty members are now dually-credentialled at both VGH and SPH. The VGH & UBC Hospital Foundation provided capital funding for new and upgraded equipment in the Psoriasis & Phototherapy Clinic and the Lions Laser Skin Centre. Similarly the BC Children’s Hospital also provided funds to support two new lasers for pediatric skin disorders at that site.
Special Honours and Awards
Dr. Stuart Maddin, Practitioner of the Year Award, Canadian Dermatology Foundation
Dr. Larry Warshawski, Promotion to Clinical Professor
Dr. Youwen Zhou, Departmental Scholar, UBC Department of Medicine
Dr. Jerry Shapiro led a successful bid to host the 2007 Intercontinental Hair Research Societies Meeting in Vancouver.
Dr. Cecil Sigal awarded the Practitioner of the Year by the Dermatology Society of British Colubmia Dr. Sheila Au, Appointment as Clinical Instructor Mr. Eric Campos, Research Scholarship, Michael Smith Foundation for Health Research (supervisor Dr. Gang Li).
UBC Department of Medicine Page 48 Annual Report 2003
ENDOCRINOLOGY
Dr. David Thompson Clinical Assistant Professor & Head
Faculty Members
Professor Prior, Dr. Jerilynn VA Clinical Professor Wilkins, Dr. Graeme VA Clinical Associate Professor Tildesley, Dr. Hugh SPH Clinical Assistant Professor Bebb, Dr. Richard SPH Clinical Assistant Professor Dahl, Dr. Marshall VA Clinical Assistant Professor Elliott, Dr. Thomas VA Clinical Assistant Professor Kendler, Dr. David VA Clinical Assistant Professor Kreisman, Dr. Stuart SPH Clinical Assistant Professor and Head Thompson, Dr. David VA Clinical Assistant Professor Wallace, Dr. Clarissa VA Clinical Instructor Gill, Dr. Sabrina SPH Clinical Instructor Johnson, Dr. Michelle SPH Clinical Instructor Kong, Dr. Jason VA Clinical Instructor Mase, Dr. Robert SPH Clinical Instructor Sirrs, Dr. Sandra VA Associate Member Bondy, Dr. Greg SPH Associate Member Kitson, Dr. Hilary Associate Member Rothstein, Dr. Ralph BCCH Associate Member Stewart, Dr. Laura BCCH Adjunct Professor Finegood, Dr. Diane Burnaby Associate Professor (Emeritus) Cairns, Dr. Alexander Professor (Emeritus) Dawson, Dr. Keith Vancouver Associate Professor (Emeritus) Thorson, Dr. Stephen
Divisional Overview
The UBC Division of Endocrinology continued to expand with a total of 14 members now on active staff and Vancouver and St Paul's Hospitals. The division runs specialty clinics in diabetes, lipids, adult metabolic disease, osteoporosis, women's health, HIV and metabolic disease, thyroid, diabetes in pregnancy and pituitary as well as providing general endocrine
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coverage to inpatients. The division has active research interests in all of the specialty clinics. Both hospital divisions have a fundraising program to help with research and educational efforts.
Teaching
Dr. Sirrs is the director for postgraduate education and Dr Elliott for undergraduate education. Dr. Bondy continues to be active in the fundamentals of medical science course. He remains a co-director of the Endocrine Week. Elective Students rotate through the Division frequently. The reviews of the students have been very positive. Unfortunately, the block teaching of Endocrinology for the second year students using modules developed by the Division are not being used in the curriculum. It is hoped that these modules will be reintroduced as part of the medical school expansion.
Internal medicine residents rotate through the division in 4 - 8 week blocks. They receive exposure to inpatient consultations, outpatient clinics and office practice and weekly formal teaching sessions. Outpatient clinics include: Diabetes Centre, Lipid Clinic, HIV and Metabolic Disease Clinic, Women’s Health, General Endocrine Clinic, Osteoporosis Clinic, Thyroid Clinic, Pituitary Clinic, and Adult Metabolic Disease Clinic.
The division had two new fellows in 2003. Dr. Michelle Fung continues in the Clinical Investigator Program and is completing a Master's in Health Care and Epidemiology. She is receiving special training in islet cell transplantation.
Family Practice residents are now rotating regularly through the Diabetes Centre Teaching Centre at Providence Health Care, averaging approximately 4 per year. This rotation continues to be highly regarded.
Many division members participate in continuing and community medical education activities.
Research
The division is engaged in a number of research activities.
A major new initiative is the establishment of an islet cell transplantation program at Vancouver Hospital. This is a joint program with the Department of Surgery and should keep the University at the forefront of this area for many years. It will be run as a research study aimed at identifying which patients with type 1 diabetes are best suited for an islet cell transplant. The first year was very successful with several patients being able to stop insulin.
Division members at both hospitals are involved in a large number of clinical trials in diabetes. They focus on diagnostic tools, therapeutic agents, natural history and prevention of complications. A number of lipid studies are closely linked with the diabetes research. The area of Women's Health and Osteoporosis continues to grow with a number of studies being performed by Drs. Prior, Kendler and Gill. Dr. Sirrs continues to be active in adult metabolic
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disease research. Dr. Johnson joined our division in 2002 and is developing research in pituitary along with Dr Wilkins. Other active areas of research include Men’s Health, Metabolic alternatives in HIV and Cystic Fibrosis.
Clinical Services
The division continues to expand clinical activity with the increasing prevalence of endocrine disease and the increasing recognition of the need for specialized care to ensure optimal outcomes. Current areas of activity include: Diabetes, Lipid Metabolism, HIV and Metabolic Disease, Women’s Health, Osteoporosis, Thyroid Disease, Pituitary Disease, and Men’s Health.
One noteworthy initiative is the development of an acute cardiac diabetes service coordinated by Dr. Dahl at Vancouver Hospital and Dr. Gill at St Paul's. The goal of this service is to improve clinical outcomes and reduce length of stay in certain patients.
Special Awards
Dr. M. Johnson: Women in Endocrinology Travel Award 2002
Dr. S. Gill UBC Department of Medicine Departmental Scholar Award, 2003 UBC Department of Medicine Departmental Scholar Award, 2002 Donald M. Whitelaw Award for Outstanding Grand rounds Presentation, UBC Dept. of Medicine, 2002
Dr. H. Tildesley Member, Support Staff, Canadian National Swim Team for Swimmers with a Disability, Argentina, December 2002
Web Site
Last year a web site was completed www.providencediabetes.ubc.ca. This is also linked with pages outlining Divisional activities at Providence Health Care. This site has had approximately 5000 "Hits" per month.
Future Directions
The division plans to increase its research activities in the areas described. The islet cell program presents a unique opportunity to make major advances in the treatment of type 1 diabetes. We hope to be able to continue to recruit new members to help achieve these goals. Providence has identified a need for two additional endocrinologists over the next 6 years. We need to increase the number of endocrinologists being trained to meet the needs of the province. This will require increased funding that may be provided with the medical school expansion. A
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major challenge will be to provide endocrinology teaching to an expanded number of students, especially if they are in a number of areas around the province.
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GASTROENTEROLOGY
Dr. Urs Steinbrecher Professor & Head
Faculty Members
Professor Freeman, Dr. Hugh VA Professor and Head Steinbrecher, Dr. Urs VA Associate Professor Anderson, Dr. Frank VA Associate Professor Salh, Dr. Baljinder Singh VA Associate Professor Yoshida, Dr. Eric VA Clinical Professor Halparin, Dr. Lawrence SPH Clinical Associate Professor Byrne, Dr. Michael VA Clinical Associate Professor Carr, Dr. Donald VA Clinical Associate Professor Kwan, Dr. Peter VA Clinical Associate Professor Weiss, Dr. Alan VA Clinical Assistant Professor Amar, Dr. Jack VA Clinical Assistant Professor Enns, Dr. Robert SPH Clinical Assistant Professor Erb, Dr. Siegfried VA Clinical Assistant Professor Gray, Dr. James VA Clinical Assistant Professor Tai, Dr. Isabella VA Clinical Assistant Professor Whittaker, Dr. John SPH Clinical Instructor Fishman, Dr. Martin Richmond Clinical Instructor Lam, Dr. Eric SPH Associate Member McManus, Dr. Bruce SPH Visiting Scientist Gomez-Munoz, Dr. Antonio Vancouver Clinical Professor (Emeritus) Bogoch, Dr. Abraham Clinical Professor (Emeritus) Chaun, Dr. Hugh Vancouver Associate Professor (Emeritus) MacDonald, Dr. Walter Clinical Professor (Emeritus) Stordy, Dr. Stanford
Divisional Overview
The UBC Division of Gastroenterology consists of 5 UBC full-time faculty members, 12 clinical faculty members, 2 associate members, 4 emeritus professors, and one visiting professor. These staff are based at St. Paul’s Hospital, Vancouver General Hospital, UBC Hospital, Vancouver
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Cancer Centre, B.C. Transplant Society, and Richmond General Hospital. There are active gastroenterology inpatient/consult services at Vancouver General Hospital and St. Paul’s Hospital as well as a liver transplant unit at Vancouver General Hospital and B.C. Transplant Society. The ambulatory care facilities include a large hospital-based clinic at Vancouver General Hospital, as well as hospital-based or adjacent offices at St. Paul’s, UBC Hospital, and Richmond. The GI subspecialty training program has 3 trainees, plus one liver transplant fellow. The basic research focus of the division is on molecular and biochemical abnormalities underlying GI cancer and inflammatory bowel disease. The division is also engaged in an active and multifaceted clinical research and clinical trials program.
Teaching
Undergraduate: The GI Division plays a key role in the enhancement and ongoing improvement of the GI block in phase II of the undergraduate curriculum. In addition to updates and revisions to the cases, lectures, and labs, priorities for 2004 are to plan for the expansion of the medical school class size over the next 5 years, to increase the quality, quantity, and accessibility of exhibits associated with the block cases, and to renew online resources for the block. The Division has recruited Dr. Nazira Chatur to take over as Undergraduate Program Director for GI.
Postgraduate: Dr. Peter Kwan was appointed Director of the GI training program in July 2003. The division is proud of the excellent trainees currently enrolled in or accepted into the program (Dr. Nazira Chatur 2002-4, Drs. Stacy Shapira and Jaber Al-Ali for 2003-5, and Dr. Henry Chung for 2004-2006). Dr. Jin-Kee Ho started his training with the liver transplant team as the UBC/Fujisawa Transplant Fellow in July 2003. Dr. Hamad Al-Othmani completed a therapeutic endoscopy/hepatology fellowship in July 2003.
Experimental Medicine: Dr. Bill Salh coordinates the GI components of the Experimental Medicine Program. There are currently 5 graduate students from the GI Division registered in Experimental Medicine. In addition, one international PhD student, two summer students, and two post-doctoral fellows are supervised by GI division members.
Continuing Medical Education: In 2003, the GI Division organized several accredited CME courses, including the seventh Annual Digestive Disease Week Review Course for subspecialists, and an Update in Gastroenterology course. Both were well-attended and highly-rated events.
Research
Division members generated more than 50 publications in peer-reviewed journals in 2003, and associate members added an additional 25 papers. This is the highest publication productivity for the division in at least 2 decades, and the expectation is that growth will continue. Several division members including Drs. Salh, Steinbrecher, and Tai conduct active basic research programs supported by national and regional granting agencies (CIHR, HSFC, CCFC, and Canadian Society for Intestinal Research). The Division is expanding clinical research and
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clinical trials activities, and is involved in more than 30 trials in a variety of clinical areas including viral hepatitis, liver transplantation, inflammatory bowel disease, esophageal reflux disease, peptic ulcer disease, and functional bowel disorders. As a result of recruitment initiatives over the past year, we have attracted three new clinician-scientists to the division's faculty (Drs. Byrne, Lam, and Tai) who will build on existing fundamental and clinical research strengths in the division.
Clinical Services
Developments in 2003 include establishment of a core resource centre for the B.C. Hepatitis Program in collaboration with BCCDC. Renovation of space for this program was completed adjacent to the existing VGH GI outpatient clinic in Willow Chest Centre and the educational and research activities of the program have been relocated to this new facility. Reconfiguration of acute services at UBC Hospital has resulted in a shift of inpatient GI medical activities to VGH, and in expansion of the outpatient endoscopy activies in a new endoscopy unit at UBCH. The inpatient GI service at VGH was moved to the 9th floor of the new JPP Tower together with General Surgery and Solid-Organ Transplant. This is proving to be a very functional adjacency tht facilitates seamless interdisciplinary care of patients with complex GI and hepatobiliary disorders. The VGH division is building an integrated endoscopy data platform that will provide enhanced report generation including image documentation, and will serve as a tool for clinical research and quality assurance/outcome analysis. This is scheduled for implementation by September 2004. The St. Paul’s division has spearheaded development of a provincial endoscopy database project, and the process toward bringing this online is continuing.
Administration and Future Directions
The Division underwent a review in July 2003, and this will serve as the first step to administrative renewal. While the division has had able leadership, the reviewers felt that greater emphasis was required to strengthen the university division and foster interhospital cooperation as opposed to the current focus individual hospital divisions. It is expected that a search will be launched in 2004. Meanwhile, recruitment initiatives currently underway will add two new members in 2004, Dr. Alnoor Ramji at St. Paul’s, and Dr. Nazira Chature at Vancouver General Hospital.
Special Honours and Awards
Several division members serve on or chair committees of professional organizations, editorial boards of medical and scientific publications, and on grant review committees of major peer- reviewed granting agencies including CIHR, CCCF, CAG, CASL, and HSFC.
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GENERAL INTERNAL MEDICINE
Dr. Iain Mackie Clinical Professor & Acting Head
Faculty Members
Professor Page, Dr. Gordon VA Professor Wright, Dr. James (Jim) VA Associate Professor Palepu, Dr. Anita SPH Associate Professor Rangno, Dr. Robert SPH Associate Professor Studney, Dr. Donald VA Clinical Professor and Acting Head Mackie, Dr. Iain VA Clinical Associate Professor Hatala, Dr Rose SPH Clinical Associate Professor Kassen, Dr. Barry VA Clinical Associate Professor Kennedy, Dr. James SPH Clinical Associate Professor Onrot, Dr. John (Jake) SPH Clinical Assistant Professor Arseneau, Dr. Richard SPH Clinical Assistant Professor Ayotte, Dr. Brian Sushwap Lake Clinical Assistant Professor Baillie, Dr. Hector Nanaimo Clinical Assistant Professor Busser, Dr. James VA Clinical Assistant Professor Dunne, Dr. James VA Clinical Assistant Professor Magee, Dr. Laura Women's Health Ctr. Clinical Assistant Professor Ong-Lam, Dr. May SPH Clinical Assistant Professor Perry, Dr. Thomas VA Clinical Assistant Professor Wakefield, Dr. Robert VA Clinical Instructor Auersperg, Dr. Edward Pitt Meadows Clinical Instructor Broder, Dr. Sarah Penticton Clinical Instructor Caswell, Dr. Sherri VA Clinical Instructor Chan, Dr. Alex Chong Hen VA Clinical Instructor Cunningham, Dr. Kenneth SPH Clinical Instructor Duke, Dr. Stephen Victoria Clinical Instructor Ervin, Dr. Francis (Frank) Maple Ridge Clinical Instructor Hawley, Dr. Philippa VA Clinical Instructor Holmes, Dr. Cheryl Kelowna Clinical Instructor Khan, Dr. Nadia SPH
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Clinical Instructor Kincade, Dr. David Kamloops Clinical Instructor McKay, Dr. Rhonda SPH Clinical Instructor Purkiss, Dr. Susan BCW Clinical Instructor Roberts, Dr. James VA Clinical Instructor Sunderwood, Dr. Jennifer VA Clinical Instructor Wong, Dr. Steven VA Associate Member Birmingham, Dr. Carl Laird SPH Associate Member Zaidel, Dr. Patrick Burnaby Clinical Professor (Emeritus) Johnson, Dr. Archibald Clinical Professor (Emeritus) McDonnell, Dr. C. Edward Clinical Professor (Emeritus) Paige, Dr. Bruce Clinical Assc Professor (Emeritus) Rennie, Dr. Charles Associate Professor (Emeritus) Sanders, Dr. Harvey North Vancouver Professor (Emeritus) Schulzer, Dr. Michael VA
Divisional Overview
The Division of General Internal Medicine at UBC is a large multidisciplinary group of physicians who have a common interest and expertise in the practice of General Internal Medicine. The Division has a large number of full-time members, who practice General Medicine in the UBC Teaching Hospitals, plus part-time members who are either subspecialists in other areas of Internal Medicine or community internists.
2003 saw a significant growth in membership of the Division with the addition of a number of community internists. Community internists play a growing role in the education of residents and provide a learning opportunity in the community that complements training received in the university-affiliated teaching hospitals. With the expansion of the medical school, slated to begin in 2004, community internists in many cities and towns in B.C. will play an increasingly important role in resident and medical student education.
Division members continue to contribute to General Internal Medicine at a national level. Dr. Barry Kassen continued his role as Head of the Internal Medicine Oral Examination Board and a member of the Internal Medicine Specialty Committee at the Royal College of Physicians and Surgeons. He is also the BC representative on the Canadian Society of Internal Medicine. Dr. Iain Mackie also sits on the Specialty Committee and continues as the Chair of the Canadian Association of Internal Medicine Program Directors. He is also a member of the Organizing Committee for the Rocky Mountain Internal Medicine Conference. Other Division members sitting on the Royal College Examination Board include Drs. Juan Ronco, Dr. Jake Onrot, Dr. John Ward, Dr. Vinay Dhingra, Dr. Mark Roberts and Dr. Rose Hatala.
Teaching
Teaching is one of the main pillars of Divisional activity at both St. Paul’s Hospital and Vancouver Hospital. Members teach in the in-patient, out-patient and “academic” settings of the
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Division, providing teaching services to undergraduate and postgraduate Internal Medicine trainees on the medical Clinical Teaching Units, in out-patient clinics and at teaching rounds of the Department of Medicine.
Division members provide clinical care and involvement in a variety of teaching units at UBC and the Teaching Hospitals. Dr. Pippa Hawley is the education coordinator for palliative care for the Division of Palliative Care, and is helping to develop training sites for the teaching of palliative care in Kelowna and the lower Fraser Valley. Drs. Jim Busser, Jim Dunne and Tom Perry continue to act as hospital directors for the undergraduate clinical clerkship. Drs. Mark Roberts, Vinay Dhingra, Barry Kassen and Iain Mackie sit on the Postgraduate Training Programme Committee of the Department.
In summary, Division members contribute significantly to the academic fabric of the Department and Faculty of Medicine at UBC. Members make a strong contribution in areas of teaching, research and administration at the local, provincial and national levels.
Research
On the research front, Dr. Nadia Khan was awarded both a Michael Smith Foundation and a Canadian Institutes of Health Research (CIHR) scholarship. Dr. Anita Palepu had major grants in HIV research: social determinants and HIV, an evaluation of a community-based intervention in injection drug users; and, the role of injection drug use and HCV infection on tolerability of HAART and HIV-1 treatment outcomes. Dr. Laura Magee continued her role as principal investigator in the Control of Hypertension in Pregnancy Study (CHIPS). Dr. Don Studney continues his diabetes research with two projects: early insulinization strategy with insulin glargine vs. a standard oral strategy in the management of Type 2 diabetes and: the safety and efficacy of Trileptal in patients with neuropathic pain due to diabetic neuropathy. Dr. Rose Hatala, Iain Mackie and Barry Kassen received funding from the Royal College of Physicians and Surgeons to evaluate a new assessment (mini-CEX) as a high stakes assessment of clinical competence. Dr. Stefan van Eeden continues his ground-breaking research in the role of monocytes and multipotential stem cells in lung diseases and was the William Thurlbeck Distinguished Researcher. He also researches in the area of air pollution-induced air pollution.
Dr. Jim Wright, continues his work in the Cochrane Collaborative, chairing the Cochrane Hypertension group based in Vancouver. Dr. Don Studney is a member of the Cochrane Renal Group. Dr. Iain Mackie was the lead investigator for British Columbia in a major-CIHR funded study of medical errors, assisted by Dr. Robert Wakefield.
Special Honours and Awards
Division members continue to demonstrate teaching expertise through the winning of teaching awards. Dr. Iain Mackie won the Vancouver Hospital Medical Staff Association Award for Excellence in Teaching.
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GERIATRIC MEDICINE
Dr. Graydon S. Meneilly Professor & Head
Faculty Members
Professor Beattie, Dr. B. Lynn VA Professor and Head Meneilly, Dr. Graydon VA Assistant Professor Madden, Dr. Kenneth VA Clinical Associate Professor Adler, Dr. Reva VA Clinical Associate Professor Dian, Dr. Larry VA Clinical Associate Professor Martini, Dr. Janet SPH Clinical Assistant Professor Chung, Dr. Maria SPH Clinical Assistant Professor Hill, Dr. Amanda VA Clinical Assistant Professor O'Connor, Dr. Peter St. Mary's Clinical Assistant Professor Rauscher, Dr. Christopher VA Clinical Assistant Professor Wong, Dr. Roger VA Clinical Instructor Barnett, Dr. Kim SPH Clinical Instructor Bater, Dr. Marilyn Royal Jubilee Clinical Instructor Bell, Dr. Kathryn VA Clinical Instructor Cook, Dr. Wendy SPH Clinical Instructor King, Dr. Kim Nanaimo Clinical Instructor Kushner-Kow, Dr. Janet St. Vincent's Clinical Instructor Malone, Dr. Marilyn VA Clinical Instructor Menezes, Dr. Janice SPH Clinical Instructor Ranchod, Dr. Hetesh Mount St. Joseph
Divisional Overview
The Division of Geriatric Medicine currently has 15 faculty at PHC and VA and 4 faculty in distributed sites. It delivers a wide range of clinical services spanning all sites of Providence Health Care and VA, including active geriatric consultation services, in-patient acute care for elders (ACE), geriatric activation and assessment beds, geriatric day hospitals and multiple outpatient clinics. Clinical services are provided in the community through outreach and through one faculty member who works primarily with community provider teams. The division's major area of research emphasis is in health service research although there are active research programs in diabetes, dementia, osteoporosis, falls prevention and cardiovascular disease.
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Teaching
Undergraduate: Dr. Reva Adler coordinates Phase V for the Undergraduate Education Committee of the Department of Medicine and will coordinate this phase for the medical school expansion. Dr. Janet Kushner-Kow is the Representative for the undergraduate teaching program for the UBC Division of Geriatric Medicine. She has recently revised the undergraduate curriculum for second year bedside teaching in Geriatric Medicine and is also actively involved in the Brain and Behaviour Week in PBL. It is anticipated that our undergraduate teaching workload will increase with the medical school expansion, particularly in view of the fact that geriatrics is meant to be a focus of the island medical program.
Postgraduate: Under the leadership of Dr. Larry Dian our training program continues to be actively involved in the teaching of internal medicine residents and fellows in the principles of the care of the frail elderly. Our division members also participate actively in the clinical teaching units and noon rounds for medical residents. Drs. Reva Adler and Janet Kushner-Kow have created an inter-professional educational programme for geriatrics to be used in universities and communities throughout British Columbia.
Continuing Medical Education: In 2003 the Division members were active participants in numerous CME events which included programs in osteoporosis, falls and fractures, dementia, diabetes and other topics. The Division Seminar program takes place weekly during the academic year, ably directed by Drs. Kenneth Madden and Janet Kushner Kow. A highlight for Division members was the Geriatric Medicine Advance 2003 held in Whistler in the Fall.
Research
Dr. Meneilly is a member of the board of the CIHR Institute for Aging. He is also a member of the Steering Committee for the Canadian Longitudinal Study on Aging, the first longitudinal study of its kind in Canada. Dr. Larry Dian presented a poster on the effects of aging on markers of bone resorption at the International Osteoporosis Foundation Meeting and was involved in the development of a consensus paper on the use of parathyroid hormone. Dr. Roger Wong continues to conduct research in health education in geriatrics. He is currently completing a randomized controlled trial of teaching geriatric concepts to physicians. He is also involved in clinical outcomes research on the impact of age on hospital utilization, and optimizing care for acutely ill seniors in ACE units. Dr. Beattie is involved in multiple research projects related to dementia and Chairs the Research Policy Committee for the Alzheimer Society of Canada. She is also a member of the CIHR Gender, Sex and Health Committee. Dr. Reva Adler has represented Canada at a number of international conferences on genocide in the past two years. She holds a grant from the Vancouver Foundation to research access to health services for older immigrants to Canada. Dr. Marilyn Malone is actively involved in collaboration with colleagues at SFU and UBC in developing a falls prevention program. Dr. Ken Madden has implemented his research program in cardiovascular physiology and pathophysiology in aging. Dr. Janet Martini and her colleagues in Providence Health Care are developing a research focus in
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performance review and continuous quality improvement with ongoing evaluation of service delivery. Dr. Wendy Cook completed her Masters in Health Science degree through Health Care and Epidemiology (awarded November 2003). She is beginning her research program in geriatric nephrology in collaboration with a nephrologist (Vanita Jassal) at the University Health Network in Toronto to measure the incidence, consequences, and risk factors for falls in seniors on hemodialysis and peritoneal dialysis. A follow-up of the cohorts is ongoing. Dr. Cook is involved in a research program in falls prevention in collaboration with the Bone Health Research Group at VA. Dr. Philip Lee has commenced his studies in the area of Behavioral Neurology and Dementia. He was recently awarded a CIHR Fellowship. Dr. Hill is collaborating with Dr. Thorton from Simon Fraser University and Dr. Shapiro from the Division of Nephrology, looking at cognition in predialysis patients.
Clinical Services
At both Providence Health Care and Vancouver Hospital clinical activities continue to increase. At the Vancouver Hospital the volume of in-patient consults has also increased. We have established a SAFE Geriatric assessment unit with a focus on regional and provincial needs which operates at the UBC hospital site. The Division is actively involved in patient assessment and management at the VGH STAT Centre and will participate in planning future community- based GEM services in Vancouver Community Health Services.
Administration
The leadership Structure at Providence Health Care has undergone a significant change over the past year. Dr. B. Lynn Beattie is Acting Head, Division of Geriatric Medicine. Dr. Janice Menezes is the Physician Operations Leader at St. Paul’s. Dr. Janet Martini is the Physician Program Director for the Elder Care Program for PHC. This includes Geriatric Medicine, Geriatric Rehabilitation and Residential Care. At VGH Dr. Meneilly is the Chairman for the Department of Medicine at both VGH and UBC. Dr. Larry Dian is the VGH Division Head for Geriatric Medicine. Dr. Reva Adler is the Medical Director of the VGH STAT Centre. Dr. Amanda Hill continues in her role as Medical Director, Community and Specialty Medicine. Dr. Roger Wong continues his roles as Medical Director, Geriatric Consultation Program and Medical Manager, ACE unit at VGH.
Special Honours and Awards
Dr. Reva Adler was recently awarded a Fulbright scholarship. Dr. Meneilly was named to the Canadian Institute of Academic Medicine.
Dr. Graydon S. Meneilly, Chair, Department of Medicine VGH and UBC
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HEMATOLOGY
Dr. Allen Eaves Dr. Stephen Nantel Dr. Michael Barnett Head: Acting Head : Head: Jan 1 - 31, 2003 Feb 1 – Oct 31, 2003 Nov 1 – Dec 31, 2003
Faculty Members
Professor and Head Eaves, Dr. Allen VA/BCCA Professor Humphries, Dr. Keith BCCA Professor Schrader, Dr. John VA Associate Professor Smith, Dr. Clayton VA/BCCA Clinical Professor Ballem, Dr. Penny BCW Clinical Professor and Head Barnett, Dr. Michael VA/BCCA Clinical Professor Buskard, Dr. Noel VA Clinical Professor Hogge, Dr. Donna VA/BCCA Clinical Professor Lansdorp, Dr. Peter BCCA Clinical Associate Professor Benny, Dr. Barrett VA Clinical Associate Professor, Ac Head Nantel, Dr. Stephen VA/BCCA Clinical Associate Professor Nevill, Dr. Thomas VA/BCCA Clinical Associate Professor Shepherd, Dr. John VA/BCCA Clinical Associate Professor Sutherland, Dr. Heather VA/BCCA Clinical Associate Professor Vickars, Dr. Linda SPH Clinical Assistant Professor Forrest, Dr. Donna VA/BCCA Clinical Assistant Professor Toze, Dr. Cynthia VA/BCCA Clinical Instructor Galbraith, Dr. Paul SPH Clinical Instructor Lavoie, Dr. Julye VA/BCCA Clinical Instructor Li, Dr. Charles SPH
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Clinical Instructor Petraszko, Dr. Tanya VA Clinical Instructor Song, Dr. Kevin VA Clinical Instructor Sreenivasan, Dr. Gayatri VA Clinical Instructor Tsang, Dr. Peter VA Associate Member Coupland, Dr. Robert VA Associate Member Eaves, Dr. Connie BCCA Associate Member Horsman, Dr. Douglas BCCA Associate Member Naiman, Dr. Sheldon SPH
Divisional Overview
The UBC Division of Hematology includes 25 staff and 4 associate staff members based at the Vancouver General Hospital (VGH), the Vancouver Cancer Centre (VCC) and the Terry Fox Laboratory (TFL) of the British Columbia Cancer Agency (BCCA), St. Paul’s Hospital (SPH), BC Women’s & Children’s Hospital and UBC. In 2003, laboratory research programs at TFL and UBC brought in peer-reviewed operating support of $3.2 million and CFI equipment funds of $2.1 million and clinical research at VGH and SPH brought in $180,000. There were a total of 48 peer-reviewed publications. Training and patient care remained at the forefront of clinical activities. Trainees in the Division as a whole included 4 Hematology fellows, 4 Leukemia/BMT fellows, 21 laboratory post-doctoral fellows and 10 graduate students.
Teaching
Undergraduate: This was the 5th year of the Blood & Lymphatics Block in the Problem Based Learning course.
Postgraduate: A total of 31 Residents in the Internal Medicine Program took hematology-based electives during the past year. These were one or two month blocks spent on the Hematology Consultation Service at VGH or SPH.
Subspecialty Training: Four General Hematology fellows were based at VGH. Rotations included the General Hematology Consultation Service, Leukemia/BMT Service, Blood Transfusion Service, Cell Separator Unit, Out-patient Clinics and Hematopathology. Rotations were also taken at SPH, VCC, BC Women’s and Children’s Hospital. These positions were filled by Dr. Ahmad Al Saeed, Dr. Lynda Foltz, Dr. Yulia Lin and Dr. Leslie Zypchen.
Leukemia/Bone Marrow Transplantation Fellowship: The Leukemia/BMT Program had four positions available for clinical training in the management of patients with leukemia and those undergoing hematopoietic stem cell transplantation. These positions were filled by Dr. Birgit Christ, Dr. Richard Doocey, Dr. Asha Johny and Dr. Sharif Khan.
Postdoctoral Training: Division Members conducting bench research in the TFL trained 21 postdoctoral fellows, of whom 13 were PhD’s, 4 MD’s and 4 MD/PhD’s.
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Experimental Medicine: In the TFL, the Experimental Medicine Program accommodated 5 graduate students, one of whom held both a CIHR and a MSHRF studentship.
Continuing Medical Education: Division Members attended numerous national and international meetings both as attendees and speakers.
Research
Clinical research was centered on hematological malignancies at VGH/VCC and thrombosis at SPH. As well as in-house studies, significant contributions were made to national and international trials. Laboratory research based at the TFL continued to focus on the regulation of normal and malignant hematopoietic cell growth and differentiation with special emphasis on the myeloid leukemias, Hox genes and telomeres.
Clinical Services
The clinical services at VGH/VCC and SPH continued to cope with a high workload in terms of both inpatient and outpatient activities. At VGH/VCC, recruitments resulted in the Leukemia/BMT, General Hematology and Cell Separator Unit programs becoming replete with senior staff. At SPH, the Alternate Payments Branch of the MOH funded 4 hematologists under a Clinical and Academic Service Contract (CASC) with a fifth position unfilled.
Administration
After 18 years of leadership, Dr. Allen Eaves stepped down as Head of the Division. The international renown of the Division attests to Dr. Eaves’ considerable success as an administrator, entrepreneur and advocate for research during a tenure spanning nearly 2 decades. Dr. Donna Hogge and Dr. Stephen Nantel completed duties as Acting Director of Leukemia/BMT and Acting Head of Division, respectively. Both served the Division admirably during difficult times.
New appointments included Dr. Michael Barnett as Head of the Division and Dr. Clayton Smith as Director of the Leukemia/BMT Program as well as Dr. Raewyn Broady and Dr. Chantal Leger as staff hematologists at VGH and SPH, respectively.
Dr. Linda Vickars (Head of Hematology at SPH), Dr. Stephen Nantel (Director of the Clinical Practice Unit for Hematology/BMT at VGH), Dr. Barrett Benny (Director of the Cell Separator Unit at VGH), Dr. Peter Tsang (Director of the Hematology Training Program) and Dr. Charles Li (Coordinator of Undergraduate Teaching) continued in leadership positions.
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Future Directions
After a period of flux, the Division looks forward to the challenges ahead with renewed vigor. The main research goals will be to enhance activity at the laboratory/clinical interface in hematological malignancy and to expand efforts in thrombosis. In addition, new collaborations, e.g., with the Centre for Blood Research at UBC will be pursued. In regard to clinical services, the priorities will be to achieve a full complement of funded staff at SPH and to negotiate a CASC for General Hematology and Cell Separator Unit staff at VGH.
Special Honours and Awards
Dr. Connie Eaves – Robert L. Noble Prize for Excellence in Cancer Research
Dr. Keith Humphries – UBC Izaak Walton Killam Research Prize (Sr. Science category)
Dr. Shelley Naiman – Department of Medicine Clinical Teaching Award
Dr. Clayton Smith – Michael Smith Foundation Senior Scholar Award
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INFECTIOUS DISEASES
Dr. Neil E Reiner, Professor and Head Dr. H Grant Stiver, Professor and Assistant Head
Faculty Members
Professor and Head Reiner, Dr. Neil VA Professor Bowie, Dr. William VA Professor Brunham, Dr. Robert BCCDC Professor Chow, Dr. Anthony VA Professor Montaner, Dr. Julio SPH Professor and Assistant Head Stiver, Dr. H. VA Associate Professor Av-Gay, Dr. Yossef VA Assistant Professor Cherkasov, Dr. Artem VA Assistant Professor de Haan, Dr. Marie VA Assistant Professor Grigg, Dr. Michael VA Assistant Professor Hmama, Dr. Zakaria VA Assistant Professor Steiner, Dr. Theodore VA Assistant Professor Tyndall, Dr. Mark SPH Clinical Professor Burdge, Dr. David BCW Clinical Professor Chan, Dr. Robert SPH Clinical Professor Phillips, Dr. Peter SPH Clinical Professor Rekart, Dr. Michael BCCDC Clinical Assistant Professor Harrigan, Dr. Paul SPH Clinical Assistant Professor Montessori, Dr. Valentina SPH Clinical Assistant Professor Press, Dr. Natasha SPH Clinical Instructor Reynolds, Dr. Robert VA Associate Member Isaac-Renton, Dr. Judith BCCDC Associate Member Jewesson, Dr. Peter VA Associate Member Marra, Dr. Fawziah BCCDC Associate Member McMaster, Dr. W. C&W Health Ctr Associate Member Money, Dr. Deborah BCW Associate Member O'Shaughnessy, Dr. Michael SPH Associate Member Patrick, Dr. David BCCDC Adjunct Professor Sanghera, Dr. Jasbinder Kinetech
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Visiting Scientist Lopez, Dr. Martin VA Visiting Scientist Papavinasasundaram, Mr. Kadambavanasundaram Visiting Scientist Sagheb, Dr. Mohammad Javad VA
Divisional Overview
Dr Neil Reiner, Professor and Head, received Fellowships in Clinical Pharmacology from Case- Western Reserve University, Cleveland, Ohio and in Infectious Diseases and Immunology from the University of Colorado Medical Centre. His research is concerned with host defense and the cell biology of intracellular infection, leading to identification of novel vaccine and drug targets in microbial pathogens. Dr Grant Stiver, Professor and Assistant Head, received his MD and training in internal medicine from the University of Manitoba, and a Fellowship in Infectious Diseases from the University of Colorado. His clinical research interests include respiratory tract infection, particularly influenza and influenza vaccine efficacy.
The Division of Infectious Diseases (ID) has experienced significant and positive growth during the past 10 years. As a result of these successes, it makes substantial contributions to the clinical, teaching and research missions of the hospitals it serves and to the UBC Faculty of Medicine. Currently the Division has 14 clinicians/clinician scientists and 5 basic scientists who are primarily based at St. Paul's Hospital and at Vancouver General Hospital, with a small number of faculty located at the UBC & BCCDC and Children’s and Women’s Hospital. An additional 7 Associate members also contribute to the strong academic focus of the Division. Along with a clinical training program for rotating medical students and residents and a Royal College accredited subspecialty training program, the Division also runs an active postgraduate research program.
Teaching
The Division has maintained its broad and substantial contributions to education within the Faculty of Medicine. Elective training in Infectious Diseases inpatient programs continues to be attractive for students and residents from a range of UBC specialties and programs, other university programs, as well as from other countries.
Undergraduate: The Division upholds a significant commitment to undergraduate education through teaching of Clerkship Half Days and Host Defense Infection Block in the PBL curriculum, and through rotations of clinical clerks on the inpatient, infectious diseases teaching and consultation service. Dr. Grant Stiver continues his key role as Director, Undergraduate Education for the Faculty of Medicine.
Postgraduate: The Division continues to maintain a leading role and high profile in teaching of resident trainees at multiple levels. Rotations involving inpatient and outpatient training at St Paul’s Hospital and Vancouver General Hospital accommodated Residents from Medicine,
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Infectious Diseases, Dermatology, Neurology, Medical Microbiology, and Obstetrics/ Gynecology. At VGH, 13 Pharmacy Residents were included in patient care teams. Trainees from other medical programs such as McGill, Toronto, McMaster, Ottawa, Calgary and Washington Universities received elective training at both hospital sites. Subspecialty Training Infectious Diseases Fellows, Rich Lester and Mark Hull, shared their training program with a Clinical Fellow from Hong Kong, Jack Wu and Anouf Nematallah from Saudi Arabia. Upon completion of his ID training in June, Abdu Sharkawy joined the St. Paul’s Hospital ID program as a locum for a Faculty member on maternity leave.
Graduate Students: Through Experimental Medicine as well as the Departments of Laboratory Medicine and Microbiology and Immunology, Infectious Diseases Faculty supervised 13 graduate students and 7 post doctoral research fellows in laboratories located at Vancouver General Hospital, BCCDC and St Paul’s Hospital.
MD/PhD Program: Dr Tony Chow is a Co-Director of the UBC MD/PhD Program, an integrated program jointly administered by the Faculty of Medicine and the Faculty of Graduate Studies. The program enrolled 11 students this year. The combined MD/PhD degree prepares the students to pursue a research-intensive track of residency and postdoctoral training in a specialty or discipline of their choice, ultimately leading to a competitive and independent clinical investigative career.
TRID Program: The exciting new CIHR Training Program for Translational Research in Infectious Diseases (TRID) received funding from the Institute of Infection and Immunity/CIHR for six years through a highly competitive $1.8M award garnered by Dr Tony Chow. The specific aims of this Program are: 1) To promote and strengthen the national capacity for translational research in infectious diseases through an integrative training program, 2) To raise the national standards in the training of health researchers, 3) To cultivate and facilitate transdisciplinary and translational research in infectious diseases. Trainees include undergraduate co-op and summer research students, MD/PhD students and postdoctoral research fellows, PhD doctoral students, and Clinician Investigator Program fellows.
Continuing Medical Education: Dr. David Kusner, MD, Internal Medicine, Immunology & Molecular Biology, University of Iowa, was an invited guest of the Infectious Diseases Visiting Scientist Program to present his research on Molecular Pathogenesis of Tuberculosis.
Research
Broad and vigorous research programs are carried out at St. Paul's Hospital, the Women's Centre, UBC Centre for Disease Control, and Vancouver General Hospital (Immunology and Infection Research Centre). Research interests include molecular microbial pathogenesis, host defense, microbial genomics, HIV, clinical trials, clinical epidemiology, sexually transmitted diseases, and vaccine studies. Peer reviewed research support for the past year totaled at least $4.5 M, with an additional $1.3 M in non-peer reviewed funding. The peer-reviewed publications total increased to 104 (Associates not included). Highlights of new research activity include:
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The outbreak of SARS in Canada in 2003 provoked collaborative initiatives to develop vaccines for acute respiratory syndromes such as SARS. Drs Robert Brunham and David Patrick are co- investigators in Dr Brett Finlay’s SARS Accelerated Vaccine Initiative (SAVI) research initiative which is funded by the Michael Smith Foundation and BC Government for two years. Dr David Patrick is also a co-investigator in the CIHR funded SARS: A scientific collaboration to support public health response through vaccination with Dr Danuta Skowronski and collaborators.
In light of the establishment in Vancouver of the first supervised injection site in North America, two faculty members, Dr Mark Tyndall, Julio Montaner, received funding from the Vancouver Coastal Health Authority for a three year Scientific Evaluation of the Supervised Injection Site.
Drs Fawziah Marra, Bill Bowie and David Patrick are co-investigators in a newly funded project which will describe outpatient antimicrobial use in BC using the PharmaNet database.
Clinical Services
At the invitation of the Government of Ontario, Dr Bill Bowie spent 10 days in Toronto during the SARS outbreak with the SARS Science Policy Committee. Several faculty (P Phillips, D Patrick, B Bowie) were members of the Provincial SARS Committee in BC, now called the Emerging Infectious Diseases Working Group. Director of Communicable Disease Epidemiology, Dr David Patrick, who is closely involved with responses to public health emergencies such as SARS, continues interdisciplinary efforts in communicable disease control and antimicrobial resistance.
Administration
Dr Tony Chow enjoyed a productive research sabbatical at the University of California, San Diego.
Dr Robert Brunham became a member Health Canada Science Advisory Board, and also became a member of the Michael Smith Foundation of Health Research.
Dr. Michael Grigg was appointed as an Associate Member of the Department of Biochemistry.
Dr Fawziah Marra, Clinical Pharmacologist at the BCCDC and St Paul’s Hospital, became an Associate Member of the Division.
Dr Bill Bowie began international work with the $4M CIDA funded project awarded to the Canadian Society of International Health for Public Health Strengthening in Guyana which has a focus on sexually transmitted infections, HIV, TB and information technology. He joined another CIDA project in Ecuador on Sustainably Managing Environmental Health Risks.
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Future Directions
Based upon its record of success and growth, and if provided with the appropriate resources, the Division is poised to become a top tier academic unit that will be highly competitive at the international level. The primary goal is to achieve international recognition as a clinical and academic infectious diseases unit. Important priorities include: securing stable support for faculty on soft money, replacement of retiring faculty, recruitment of new clinical investigators, replacement of academic space, development of resources for research infrastructure support for equipment, administrative and lab coordinators. New research initiatives - molecular virology, infections in transplant medicine, expanded clinical research. Securing appropriate and stable levels of funding for clinical services, including expansion of clinical programs in transplant related infections, chronic viral diseases and geographic medicine.
A second goal is to develop a world class training program in ID biology. Both locally and nationally there is a critical shortage of highly trained clinician scientists in ID at all levels from population based to molecular sciences. Based upon extensive and complementary levels of expertise available between the Division of ID, the UBC CDC and the Immunology and Infection Research Centre at VH, we have the opportunity to develop a program to address this need. The objective is to build upon what is already a well functioning, highly rated program to achieve the development of a diversified, world class training program in ID biology.
Special Honours and Awards
Dr Yossef Av-Gay presented on his research, “Protein kinases as target for TB therapy” at the prestigious Gordon Research Conference on TB Drug Development at Oxford, England.
A number of division members including Drs Robert McMaster, Neil Reiner, Tony Chow, Michael Grigg, Yossef Av-Gay, Ted Steiner and Zakaria Hmama made a successful application to the Michael Smith Foundation Immunity and Infection Research Centre Infrastructure Award. This award, which is funded at $750,000 over 5 years, support core platform technologies including gene cloning and expression, micro-array analysis and a cell imaging facility.
Dr Bill Bowie became a member of two additional Michael Smith Foundation Infrastructure projects: Animal determinants of emerging infectious diseases (Centre for Coastal Health), and Strengthening Health Disparities Research in BC (IHPR).
Dr Robert Brunham was awarded the BC Public Health Award of Excellence by the BC Pharmacy Association in relation to SARS in BC.
The 2003 Donald M. Whitelaw Award for Outstanding Grand Rounds Presentation at VHHSC was awarded to Dr. Robert Reynolds.
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MEDICAL ONCOLOGY
Dr. Susan E. O'Reilly Clinical Professor & Head
Faculty Members
Assistant Professor Chi, Dr. Kim BCCA/Vancouver Assistant Professor Chia, Dr. Stephen BCCA/Vancouver Clinical Professor Connors, Dr. Joseph BCCA/Vancouver Clinical Professor Gelmon, Dr. Karen BCCA/Vancouver Clinical Professor Hoskins, Dr. Paul BCCA/Vancouver Clinical Professor MacLean, Dr. Grant BCCA/Victoria Clinical Professor Murray, Dr. Robert Nevin BCCA/Vancouver Clinical Professor and Head O'Reilly, Dr. Susan BCCA/Vancouver Clinical Professor Shah, Dr. Amil BCCA/Vancouver Clinical Professor Swenerton, Dr. Kenneth BCCA/Vancouver Clinical Professor Weinerman, Dr. Brian BCCA/Victoria Clinical Associate Professor Coppin, Dr. Christopher BCCA/Fraser Valley Clinical Associate Professor Klasa, Dr. Richard BCCA/Vancouver Clinical Associate Professor Klimo, Dr. Paul Lion’s Gate Hospital Clinical Associate Professor Williams, Dr. Christopher BCCA/Nanaimo Clinical Associate Professor Wilson, Dr. Kenneth BCCA/Victoria Clinical Assistant Professor Allan, Dr. Sharon BCCA/Victoria Clinical Assistant Professor Bernstein, Dr. Vanessa BCCA/Victoria Clinical Assistant Professor Bryce, Dr. Cicely BCCA/Vancouver Clinical Assistant Professor Khoo, Dr. Kong BCCA/Kelowna Clinical Assistant Professor Knowling, Dr. Margaret (Meg) BCCA/Vancouver Clinical Assistant Professor Lee, Dr. Ursula BCCA/Fraser Valley Clinical Assistant Professor MacPherson, Dr. Nicol BCCA/Victoria Clinical Assistant Professor Melosky, Dr. Barbara BCCA/Vancouver Clinical Assistant Professor Noble, Dr. R. Royal Columbian Clinical Assistant Professor Norris, Dr. Brian BCCA/Fraser Valley Clinical Assistant Professor Sawhney, Dr. Ravinder BCCA/Fraser Valley
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Clinical Assistant Professor Sehn, Dr. Laurie BCCA/Vancouver Clinical Assistant Professor Shenkier, Dr. Tamara BCCA/Vancouver Clinical Assistant Professor Stuart, Dr. David Burnaby Clinical Assistant Professor Taylor, Dr. Marianne BCCA/Victoria Clinical Instructor Ellard, Dr. Susan VA Clinical Instructor Fenton, Dr. David BCCA/Kelowna Clinical Instructor Fitzgerald, Dr Catherine BCCA/Victoria Clinical Instructor Lee, Dr. Christopher BCCA/Fraser Valley Clinical Instructor MacNeil, Dr. Mary BCCA/Victoria Clinical Instructor Martin, Dr. Lee Ann BCCA/Fraser Valley Clinical Instructor Martins, Dr. Heidi BCCA/Victoria Clinical Instructor Sutherland, Dr. Judith BCCA/Kelowna Honorary Professor Bruchovsky, Dr. Nicholas BCCA/Emeritus Associate Member Ling, Dr. Victor BCCRC Clinical Professor (Emeritus) Goldie, Dr. James BCCA/Emeritus Clinical Professor (Emeritus) Klaassen, Dr. David BCCA/Emeritus Clinical Professor (Emeritus) Plenderleith, Dr. Ian BCCA/Emeritus Clinical Professor (Emeritus) Silver, Dr. Hulbert BCCA/Emeritus
Divisional Overview
The Division of Medical Oncology, UBC, comprises the Medical Oncology and scientific staff at the Vancouver Cancer Center, Fraser Valley Cancer Center, Surrey, Vancouver Island Cancer Center, Victoria and the newest Cancer Center for the Southern Interior, Kelowna, as well as community oncologists in Burnaby, Lion’s Gate, North Vancouver, Nanaimo and the Royal Columbian Hospital, New Westminster.
In addition to the clinical division, there is a laboratory section (Advanced Therapeutics), which is located in the British Columbia Cancer Research Center. It comprises four senior scientists and six clinical investigators who have appointments at the Vancouver Cancer Center, Department of Medical Oncology.
Medical Oncology clinical services are organized as a Provincial Systemic Therapy Program at all four centers. Undergraduate and postgraduate teaching occurs primarily at the Vancouver Cancer Center and elective opportunities are available at all other cancer centers. UBC clinical faculty at all centers are available to participate in undergraduate teaching modules.
The next few years will pose some exciting challenges and opportunities. More medical oncologists will be needed to address the rising incidence of cancer, related to the aging population. Simultaneously, many new therapies, (both curative and long-term control of different cancers) are being rapidly incorporated into our therapeutic armamentarium. Expanded
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opportunities for clinical and translational research is readily available based on the rapid emergence of new knowledge in cancer biology.
The new $100,000,000 B.C. Cancer Research Center building will open in late 2004. This state- of-the-art research facility will house a wide range of laboratory research programs including molecular oncology, and the Terry Fox Laboratory. The BC Cancer Agency Genome Sciences Centre is moving to a large laboratory facility nearby.
Teaching
The Medical Oncology Undergraduate Training Committee, chaired by Dr. Amil Shah is active in providing and planning teaching modules and clinical bedside teaching in Internal Medicine. An elective in Medical Oncology is available to UBC and visiting medical students.
The Postgraduate Training Committee, chaired by Dr. Richard Klasa, offers two-month electives in Medical Oncology to internal medicine residents from UBC and other universities. Approximately 10-16 residents per year from these and other specialty disciplines spend elective periods at the Vancouver Cancer Center. Opportunities are available for electives at all of our regional cancer centers and some financial support for travel and accommodation is available for residents choosing one of these options.
The Postgraduate Training Committee also plans and supervises the two-year subspecialty- training program in Medical Oncology. This program is based at the Vancouver Cancer Center with elective opportunities at all other centers and in community oncology practice. The six- month elective period may also be applied to laboratory or clinical research. One or two month electives at centers elsewhere in Canada or in other countries may also be considered. This program is fully approved by the Royal College of Physicians and Surgeons of Canada and has consistently received excellent reviews. The University of British Columbia and the British Columbia Cancer Agency fund eight residents (four in each year of our two year program). Additional training positions for overseas residents result in eight or nine trainees participating in this two-year program at any one time. Currently, residents participate in academic oncology training with excellent exposure to clinical practice, ambulatory care and clinical trials. Residents generally contribute to clinical research and have a number of publications and presentations to their credit. Opportunities to pursue laboratory research projects are available.
Continuing Medical Education: All medical staff are active in continuing medical education courses organized by the British Columbia Cancer Agency, other provincial, national and international bodies.
Research
Members of the Division are involved in a wide variety of phase I, phase II and phase III clinical trials. These include the development of new anti-cancer drugs, the evaluation of new doses schedules and combinations of drugs in the phase II setting and the participation in multi-
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institutional phase III studies evaluating effective new treatments on specific categories of malignancy.
Our phase I investigational new drug program is growing rapidly as a reflection of the energy and enthusiasm of the scientists and physicians in the Advanced Therapeutics section of Medical Oncology and in response to the increasing availability of new agents for testing in North America.
Our Advanced Therapeutics Section is able to evaluate new biological response modifiers, gene therapy and pharmaceutical agents through all stages from in-vitro testing in the laboratory to evaluation in human volunteers. The Vancouver Cancer Center has the only Clean Room in an academic center in Canada that is equipped and licensed for the packaging and formulation of pharmaceutical agents in small quantities for clinical testing.
At the pre-clinical level, studies are being carried out in evaluating antiangiogenesis agents, gene modifiers, enzyme inhibitors, experimental drug modulators, pre-clinical drug toxicities and drug carrier research such as liposomal encapsulated agents. Currently, the BCCA manages its own grants and these are not listed in this report.
Clinical Services
The four B.C. Cancer Centers now provide medical oncology consultations for 7,000 new patients annually and there are 50,000 ambulatory care visits to these centers. The Provincial Systemic Therapy Program, headed by Dr. Susan O’Reilly manages the $62,000,000 oncology drug budget, which supports the care of 23,000 patients annually, both within BCCA centers and in community hospitals. Opportunities for health services research projects are available and linkages with the Provincial Tumour Registry and Vital Statistics are readily available. We are uniquely positioned to further develop province-wide population-based research in health outcomes for cancer patients.
Future Directions
The major academic goal of the Division is to achieve an outstanding translational research unit that combines the excellent basic science research at the British Columbia Research Center, the input from the Genome Science Centre, the resources of our academic medical oncologists and the participation of our large patient population.
British Columbia has consistently shown the best cancer survival statistics in Canada and we are in a unique position to carry out province-wide treatment programs in both clinical and translational research. We are expanding our research agenda in health outcomes and economics.
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NEPHROLOGY
Dr. Eugene C. Cameron Associate Professor & Head
Faculty Members
Professor Keown, Dr. Paul VA Professor Quamme, Dr. Gary VA Professor Wong, Dr. Norman VA Associate Professor and Head Cameron, Dr. Eugene VA Assistant Professor Gill, Dr. John SPH Clinical Professor Chan-Yan, Dr. Clifford SPH Clinical Professor Levin, Dr. Adeera SPH Clinical Professor Werb, Dr. Ronald SPH Clinical Associate Professor Chan, Dr. Victor Royal Columbian Clinical Associate Professor Landsberg, Dr. David SPH Clinical Associate Professor Shapiro, Dr. Jean VA Clinical Associate Professor Taylor, Dr. Paul SPH Clinical Associate Professor Yeung, Dr. Choi Kit VA Clinical Assistant Professor Chiu, Dr. Anthony SPH Clinical Assistant Professor De Luca, Dr. Linda SPH Clinical Assistant Professor Duncan, Dr. John VA Clinical Instructor Copland, Dr. Michael VA Clinical Instructor Jamal, Dr. Abeed SPH Clinical Instructor Jastrzebski, Dr. Jacek VA Clinical Instructor Jung, Dr. Beverly SPH Clinical Instructor Kiaii, Dr. Mercedeh SPH Clinical Instructor Singh, Dr. Rajinder VA Professor (Emeritus) Price, Dr. John Clinical Professor (Emeritus) Rae, Dr. Angus Professor (Emeritus) Sutton, Dr. Roger
Divisional Overview
The Division of Nephrology includes 21 members based at three principal sites: Saint Paul’s Hospital (11), Vancouver General Hospital (8) and UBC Campus (2), who provide provincial leadership in research, education and clinical care within the field of renal medicine. The
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Division has a strong clinical base and provides integrated and decentralized nephrology care throughout the Vancouver Coastal Health Authority including Richmond, the North Vancouver and coastal areas. The Division has an important role in the UBC undergraduate medical curriculum, and has one of the largest nephrology postgraduate training programs in Canada. Research activities range from genetic and molecular sciences to innovative trials in renal disease and transplantation, with novel measures of health status and economic outcomes. Members of the Division assume leadership roles in the advancement of nephrology at provincial, national and international levels through their positions in the BC Provincial Renal Agency, BC Transplant Society, the Kidney Foundation of Canada, the Canadian and International Societies of Nephrology, the International Transplant Society, and US National Kidney Foundation.
Teaching
Undergraduate: The members of the Division are major contributors in the five-week Fluid & Electrolyte, Renal and Genito-Urinary Block in the first year of the Undergraduate Curriculum. Drs. E.C. Cameron (Block Chair), A. Levin (Week Chair), M. Kiaii, S. Singh, M. Copland, J. Duncan, and N. Wong participated in the ongoing development and delivery of this course.
Drs. J. Duncan and A. Jamal were Undergraduate Curriculum Representatives for 3rd Year Fluid & Electrolyte teaching and revised and presented Nephrology seminars. Dr. A. Levin and Dr. S. Singh continued to be responsible for supervision of the nephrology rotations in the Clinical Clerkship Program.
Dr. S Singh was an active participant in the Medical School Selection Committee
Postgraduate: Dr. A. Levin continued as Program Director of the Postgraduate Training Program in Nephrology during 2003. There were five Fellows in the 1st year, four Fellows in the 2nd year of the Program and two in the 3rd year doing post-fellowship research training and one in the UBC American Society of Nephrology/Transplantation Renal Transplant Fellowship Program.
Residents and Fellows were active in clinical research with submission and presentation of abstracts by the American Society of Transplant Physicians, the Canadian Society of Nephrology, the American Society of Nephrology and the UBC Resident Research Day. Three Fellows received Kidney Foundation of Canada Biomedical Research Fellowships.
Experimental Medicine: Dr. N. Wong directed the Experimental Medicine Program for the Department of Medicine (see separate report). This Program had 114 trainees including those supervised by Dr. P.A. Keown.
Continuing Medical Education: The annual BC Nephrology Day was held again in October 2003. This was a highly successful multidisciplinary meeting attracting over 200 participants from dialysis centers in British Columbia. Members of the Division participated in Continuing
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Medical Education activities at the local and provincial level. Drs. A. Levin and P. Keown maintained active speaking schedules in national and international meetings.
Research
Clinical Research: The clinical research in the Division of Nephrology emphasized outcomes research and clinical trials. The Division was actively involved in both industry-sponsored and peer-reviewed research in the areas of chronic kidney disease, dialysis and transplantation. Division members held grants from the Kidney Foundation grants, BC Research and BC Transplant Foundation and other operating grants. Dr. John Gill obtained personnel and research awards from the Kidney Foundation of Canada and the Michael Smith Foundation for Health Research.
The scope of clinical research included patients care prior to dialysis, cardiovascular disease in patients with kidney disease - determinants of outcomes and severity, vascular access monitoring and tracking programs, the relationship of monitoring systems to patient outcomes, mineral metabolism and patient outcomes, the evaluation of new medications on patient parameters, the evaluation of new immunosuppressive medications on transplant outcome, gender studies in renal disease, and ethics studies related to genetic identification of polycystic renal disease.
Basic Research: The laboratory of Dr. N. Wong conducted studies concerning the regulation of expression of vasopressin B2 MRNA in the medullary collecting system of congestive heart failure patient model. Dr. G. Quamme’s laboratory continued research on the magnesium response element that controls magnesium transport. Dr. P. Keown’s research projects include the genetic control of immune response in transplantation and arthritis through polymorphism with the cytokine gene family, economic models in transplantation and pharmacokinetics.
Administration
The Division was in the process of identifying a new Division Head to replace Dr. E.C Cameron who will have completed 10 years as Division Head in 2004. Dr. D. Landsberg served as Chair of the Management Committee. The Division made a significant contribution to the infrastructure of the Nephrology teaching and training programs.
Future Directions
The Division will continue to build on its strengths to ensure the highest quality of academic and clinical activity for the University, the health system, and the community. A new Division head will be in place in 2004 and it is anticipated that the Division will take a major role in Renal & Fluid and Electrolyte teaching in the expanded Medical School, continue leadership in nephrology postgraduate education, pursue integration of laboratory and clinical research in nephrology and introduce innovative initiatives in the delivery of care to patients with renal disease.
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Special Honors and Awards
Dr. P.A. Keown - Treasurer, International Transplant Society
Dr. A. Levin - Past President of the Canadian Society of Nephrology
- Co-Chair of Kidney Dialysis Outcomes Quality Initiative National Kidney Foundation USA
Dr. P. Taylor - President of the Western Peritoneal Dialysis Association
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NEUROLOGY
Dr. Howard Feldman Professor & Head
Faculty Members
Professor and Head Feldman, Dr. Howard VA Professor Doudet, Dr. Doris VA Professor Oger, Dr. Joel VA Professor Pelech, Dr. Steven VA Professor Stoessl, Dr. A VA Professor Tsui, Dr. Joseph VA Professor Wang, Dr. Yu Tian VA Associate Professor Kastrukoff, Dr. Lorne VA Assistant Professor Lee, Dr. Chong VA Assistant Professor Spacey, Dr. Sian VA Clinical Professor Hashimoto, Dr. Stanley VA Clinical Associate Professor Hooge, Dr. John SPH Clinical Associate Professor Javidan, Dr. Manouchehr VA Clinical Associate Professor Jones, Dr. Michael VA Clinical Associate Professor Krieger, Dr. Charles VA Clinical Associate Professor McKeown, Dr. Martin VA Clinical Associate Professor Robinson, Dr. Gordon VA Clinical Associate Professor Wong, Dr. Milton SPH Clinical Assistant Professor Beckman, Dr. Jeff VA Clinical Assistant Professor Clarke, Dr. Stephen SPH Clinical Assistant Professor Devonshire, Dr. Virginia VA Clinical Assistant Professor Foti, Dr. Dean VA Clinical Assistant Professor Gibson, Dr. Gillian VA Clinical Assistant Professor Johnston, Dr. Dean SPH Clinical Assistant Professor Keyes, Dr. Robert SPH Clinical Assistant Professor Martzke, Dr. Jeffery Scott VA Clinical Assistant Professor Mezei, Dr. Michelle VA Clinical Assistant Professor Prout, Dr. Alister SPH Clinical Assistant Professor Teal, Dr. Phillip VA Clinical Assistant Professor Thiessen, Dr. Brian VA Clinical Instructor Costantino, Dr. Anthony VA
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Clinical Instructor Murphy, Dr. Colleen VA Clinical Instructor Tai, Dr. Charles Vancouver Clinical Instructor Tessler, Dr. Barry Royal Columbian Clinical Instructor Traboulsee, Dr. Anthony VA Clinical Instructor Varelas, Dr. Michael VA Clinical Instructor Woolfenden, Dr. Andrew VA Associate Member Anderson, Dr. Duncan VA Associate Member Forwell, Dr. Susan VA Associate Member Graeb, Dr. Douglas VA Associate Member Hurwitz, Dr. Trevor VA Associate Member Leavitt, Dr. Blair VA Associate Member Li, Dr. David VA Associate Member Moore, Dr. Wayne Associate Member Sadovnick, Dr. A VA Associate Member Stowe, Dr. Robert VA Associate Member Wilkinson, Dr. Rosemary VA Adjunct Professor Bub, Dr. Daniel UVic Adjunct Professor Ruth, Dr. Thomas VA Adjunct Professor Sossi, Dr. Vesna Visiting Scientist Al-Araji, Dr. Adnan Clinical Professor (Emeritus) Anzarut, Dr. Andre SPH Clinical Professor (Emeritus) Bratty, Dr. Paul VA Clinical Assoc Professor (Emeritus) Jones, Dr. David VA Professor (Emeritus) Calne, Dr. Donald VA Professor (Emeritus) Eisen, Dr. Andrew VA Professor (Emeritus) Kim, Dr. Seung VA Professor (Emeritus) Pate, Dr. Brian VA Professor (Emeritus) Paty, Dr. Donald VA Professor (Emeritus) Sweeney, Dr. Vincent VA
Divisional Overview
The Division of Neurology is the largest division within the Department of Medicine. It has its major teaching, research and clinical activities at Vancouver General Hospital, UBC Hospital and St. Paul’s Hospital. Its faculty of 59 includes an accomplished group of clinical faculty (38), GFT faculty (14), and basic neuroscientists (7). The Division is nationally and internationally recognized for its clinical and research programs in neurodegenerative diseases, demyelinating diseases, neuromuscular disorders and cerebrovascular diseases. It has been consistently very productive in obtaining peer reviewed grant funding, and contributes importantly to both basic and clinical neurological literature. The Division also provides a high level of clinical care including tertiary and quaternary care for neurological disorders provincially. Faculty are involved in teaching and supervising all levels of students and trainees from undergraduate to post doctoral.
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Amongst the highlights for the Division in the past year has been the official opening of the Brain Research Center (BRC) on the first floor of the UBC Hospital. This Center adds to the strength and opportunity for the Division, creating a unique environment for collaborative research between clinical and basic science researchers as well as for translational research studies. Many of the basic scientists within the Division have moved into the BRC as anchor tenants and are now better able to accommodate and attract Ph.D and post doctoral students. The mission statement of the university (TREK 2000) has priorized the cluster of neurosciences and cognitive systems as a target area for research and for the allocation of Canada Research Chairs (CRCs). In the past 5 years there have been 14 CRCs awarded in this neuroscience cluster. In the final CRC competition this year Neurology submitted applications for both a senior and junior CRC award, with final adjudication pending.
The Division was pleased to provide the first award of the Dr. Donald W. Paty Endowment to Dr. Sian Spacey to provide her seminal salary support in the early years of her career as a clinician scientist. The Division had the pleasure of awarding the Ludmila and Henry Zeldowicz Award to Dr. Galina Vorobeychuk in recognition of her promise and contribution to neurological research as a resident.
New appointments to the division included Drs. Martin McKeown (UBCH), Kristine Chapman (SPH, VGH) and Colleen Murphy (VGH). Dr. McKeown was recruited from Duke University via the Salk Institute, to join the division and the Pacific Parkinson’s Research Center. Dr. Kristine Chapman was recruited to contribute to the academic UBC neuromuscular program as well as to clinical program at SPH. Dr. Colleen Murphy was appointed at VGH to contribute as a clinician educator, member of the stroke service and with a special interest in ethics in Neurology.
Teaching
Undergraduate: Division members continue to be involved in the Brain and Behaviour course during 2nd year, providing classroom lectures and bedside sessions in clinical skills at VGH and SPH. The Division is particularly grateful to the community neurologists who have faithfully supported this teaching activity.
Seminars and bedside sessions are provided in 3rd year. A 4th year clerkship is available as an elective/selective. The clerkship is based on an inpatient and outpatient experience allowing students to take advantage of all of the resources within the Division. As well as UBC students the clerkship attracts students from other medical schools in Canada and other countries.
Plans are underway to revise the 3rd year neurology teaching. An expanded seminar series reviewing neuroanatomy and the neurological examination will complement bedside clinics.
Postgraduate: The Post Graduate Residency Training currently has 15 residents at various levels of training from PGY1 to PGY5. In the first two years of our program, the residents rotate
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through various subspecialties in Internal Medicine, ICU, Emergency, as well as doing their first Neurology rotations. The PGY3-5 years are core Neurology training years. Residents do their inpatient training at Vancouver General Hospital and St. Paul's Hospital. Many outpatient subspecialty clinics are done at UBC Hospital. Our residents have been actively involved in various research projects. For the year 2003 there were 4 poster presentations at various international meetings. Dr. Galina Vorobeychuk won the Resident Scholarship Award for the AAN Annual Meeting and the AAN Travel Award. Dr. Sheila Savedia-Cayabyab’s poster presentation on PET study in Parkinson’s disease was awarded a highlighted poster at the American Academy of Neurology meeting held in Hawaii in April 2003. Some of our residents presented at the BC Neuroscience Day held in March 2003.
Fellowship Training and Awards: The Division of Neurology appointed the following individuals to fellowship and post-doctoral fellowship training in 2003:
Multiple Sclerosis Program: Dr. Helen Tremlett (post doctoral fellow of the MS Society), Dr. Penny Smyth (clinical fellow) and Dr. Alaraji Adnan (clinical fellow)
Alzheimer’s Disease and Related Disorders: Dr. Robin Hsiung (Michael Smith Foundation Health Research Post Doctoral Fellowship), Dr. Anastasia Dressler and Dr. Inge Loy-English (clinical fellow)
Parkinson’s Disease and Movement Disorders (Pacific Parkinson’s Research Center): Dr. John Adams, Dr. Andre Troiano and Dr. Wing Lok Au (clinical fellows).
Epilepsy Program: Dr. Bahrami Parviz (clinical fellow)
Stroke Program: Dr. Li Huan (post doctoral clinical fellow).
Basic Neuroscience Research: From the lab of Dr. Y.T. Wang; Dr.Yushan Wang was awarded a CIHR Fellowship for 2001-2004; Dr. Tak Pan Wong was awarded a CIHR and Michael Smith Foundation Health Research Fellowship for 2001-2004; Dr. Changiz Taghibiglou was awarded a CIHR Fellowship and a Michael Smith Foundation Health Research Fellowship for 2001-2004; Mr. Yitao Liu was awarded a CIHR/HSFC Doctoral Award and Michael Smith Foundation Health Research Studentship 2002-2005 and a CIHR Brain Star Award for his paper published in Science 2003.
Neuropsychology: Dr. Jane Kucera was appointed clinical fellow in Neuropsychology under the supervision of Dr. Jeff Martzke.
Vancouver General Hospital Neurology Service
Neurology has its clinical teaching unit located on the 5th and 6th floors of the Jim Pattison Pavilion. This unit is the only dedicated in-patient Neurology CTU in the province and has within its mandate the provision of tertiary care for complex neurological disorders. The
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inpatient program features a specialized epilepsy monitoring unit (2 beds), a stroke service (6 beds) and an allotted 6 beds for general neurology. Life and Limb policies are in place for accepting acute stroke patients, as well as neuromuscular disorders requiring plasmapheresis. In the ambulatory setting the division has dedicated neurological subspecialty clinics in dementia, Parkinson’s disease, Huntingdon’s disease, multiple sclerosis, neuro-oncology, neurogenetics and stroke prevention. The neuromuscular diseases unit has clinics for myasthenia gravis, amyotrophic lateral sclerosis and peripheral neuropathy. There are subspecialist clinical neurologists within the division dedicated to care of patients with headache, and epilepsy.
The inpatient and ambulatory programs continued to deliver high level patient care while under fiscal pressure throughout 2003. The dedication and skill of the personnel within these areas has sustained this clinical mission.
The move of the inpatient neurology service to the Pattison Pavilion in May 2003 was an important step forward for the division. Neurology patients are now located within a single area allowing more efficient care and teaching. The CTU is staffed by a faculty attending (ward manager) and residents from the neurology program and other disciplines. There is also a Consultation Service that has been developed that provides consultation to all other hospital areas and functions as a teaching service staffed by faculty attendings and resident housestaff.
St. Paul's Hospital Division of Neurology
The St. Paul’s Hospital Division of Neurology is an important part of the clinical and teaching program of the UBC Division of Neurology. Dr. Robert Keyes is the division head of SPH. This division provides tertiary referral care for the Providence Health Care network as well as to the province more widely. The SPH division participates in an important and extensive outreach program to communities in northern BC and the Yukon Territory. It is additionally involved in providing inpatient consultation services to the Mount St. Joseph’s Hospital site and Women’s Hospital. It is expected that over the ensuing months that an outpatient neurology clinic will also become functional at the Mount St. Joseph’s Hospital Site to meet the needs of the patient population it serves.
The members of the Division of Neurology at SPH includes a wide cross section of subspecialty interests including clinical neurophysiology, neuromuscular disease, multiple sclerosis, neurological diseases in pregnancy, cerebrovascular disease and neurological diseases in HIV and AIDS. A close link between the Division of Neurology at SPH and the Department of Pediatrics and the Department of Obstetrics continues by virtue of the subspecialty interests of Dr. Keyes.
At SPH there is a Rapid Access Neurology Clinic where patients requiring urgent but not emergent care are seen and provide clinical service especially to the patient population arising from the downtown core.
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There are two members of the SPH Division of Neurology who are retiring in the immediate future. A future recruitment planning process remains in place to provide for replacement of those members who are retiring.
Research
Alzheimer’s Disease and Related Dementias
The UBC Alzheimer’s Clinical Trials Program has been active in both peer reviewed and pharmaceutically sponsored research during this past year. Divisional faculty participating include: Dr. Howard Feldman (Director), Dr. Dean Foti and Dr. Jeff Beckman. The research group included Dr. Kevin Peters (cognitive psychologist), Dr. Claudia Jacova (post doctoral fellow), Dr. Robin Hsiung (Michael Smith post doctoral fellow, Jacob Grand (graduate student) and Dr. Alan Donald (statistician) and a dedicated group of research assistants and research coordinators.
The ACCORD study, a longitudinal multicenter cohort study of subjects referred with cognitive symptoms completed its 2 year longitudinal assessments and is set to complete final visit data on all subjects. This national study has been lead by the coordinating center at UBC. Collaborators/co-investigators on the ACCORD study include Dr. Howard Feldman (Principal Investigator) Dr. Alan Donald (Statistics), Dr. Dessa Sadovnick (Neurology/Genetics), Dr. Lynn Beattie, (Geriatrics), Dr. Dean Foti and Dr. Ian Mackenzie (Neuropathology). A tissue and blood bank has been developed for this study and is located in the Brain Research Center.
Peer reviewed research funding from CIHR/Alzheimer Society of Canada has been received for a longitudinal study of novel MRI techniques in mild cognitive impairment (2002-4). Dr. Kevin Peters completed his doctoral scholarships of the Alzheimer’s Society of Canada and the CIHR on this study and was awarded his PhD in 2003.
Clinical trials have continued to focus in the past year on studies of mild cognitive impairment as a precursor state to AD, with completion of a series of large clinical trials investigating the potential for delay of time to the diagnosis of AD. A core group of very experienced nurse coordinators and research assistants are critical to the success of the clinical trials program.
Clinical Activities: The Alzheimer Clinic evaluated an estimated 1500 patients in 2003. It is the main tertiary care referral center in the province for dementia assessment. New referrals can include a range of assessments including Genetics, Social Work, Neuropsychology, Geriatric Psychiatry and Neurological/Medical.
Teaching and Education: The Clinic has been very active in providing teaching to trainees of multiple disciplines at many levels. A formal one-day preceptorship training program for family physicians and specialists is in place. Clinic members participated extensively in CME activities, and on expert national international working groups and advisory committees. The Clinic is very active in public education.
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Stroke and Cerebrovascular Program
The Stroke Program at the Vancouver General Hospital continued to be very busy and productive. The VGH serves as the major referral centre for stroke and cerebrovascular diseases in B.C. A “Stroke Hot Line” pager system is available 24/7 to triage patients from around the lower mainland and southern British Columbia. In cooperation with BC Bedline we have been able to provide an acute stroke referral system for the provision of thrombolytic and interventional stroke care. The VGH Stroke team consists of stroke neurologists, diagnostic and interventional neuroradiologists, neurointerventional/neurovascular neurosurgeons, and vascular surgeons who provide state-of-the-art care to cerebrovascular patients.
The VGH Stroke Unit is now operational after initial funding and staffing problems and the organization of stroke care delivery at the VGH is poised to undergo significant changes in the coming year. Organized delivery of stroke care at the VGH will permit patients to flow from the Acute Stroke Unit to the Subacute Stroke Unit to Rehab and reintegration into the community.
The Stroke Prevention Clinic is busy two days a week and provides same day clinical and diagnostic services to patients. This clinic provides a critical resource for patients at risk of stroke and to emergency departments and physicians. Prompt and expert care reduces the need for hospitalization through the rapid evaluation of patients.
The VGH Stroke Program had an extremely busy year in educational activities. We hosted the Western Canada Stroke Day which provides education to neurologists from B.C. and western Canada. Weekly stroke rounds are held to provide education to residents and medical students. Residents and students spend time in the Stroke Prevention Clinic evaluating and making decisions on urgent cases. The Stroke neurologists continue to give Grand Rounds, medical rounds and talks at CME events to educate physicians around the province. Public forums have been held by the Heart and Stroke Foundation with the participation of stroke neurologists and others.
On an international level, members of the Stroke Program delivered posters and platform presentations at the American Stroke Association meeting, the Canadian Congress of Neurological Sciences, the American Academy of Neurology, and the European Stroke Conference.
The Clinical Trials Program has been extraordinarily busy with grant and industry-funded trials, being engaged in six stroke prevention trials, (MATCH, ACTIVE, SPARKL, CHARISMA, PRoFESS and FASTER), three trials of neuroprotective agents (mRECT, ONO, SAINT), a IIb- IIIa trial (AbESST II), as well as reperfusion studies including the use of novel catheter devises and intra-arterial therapies (IMS II). Members of the Stroke Program serve on international steering committees as well as officers and committee members of the Canadian Stroke Consortium.
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Multiple Sclerosis
The UBC clinical and research MS groups have continued to receive international recognition as leaders in the field of Multiple Sclerosis. In 2003 the MS Clinic had 4517 active charts, 3239 patients visits, and 285 new patients. There were 6 consultant neurologists and 2 appointed clinical fellows: Dr Penny Smyth on a Fellowship from Biogen Canada and Dr Adnan Al-Araji Director of the MS clinic in Bagdad on a Dupré Fellowship from the International Federation of Multiple Sclerosis (London UK). There are close collaborations in patient care with Dr A. Jiwa for psychiatric care, Dr S. Elliot for sexual care and the neuro-ophthalmology.
The MS clinic has provided outreach through 3 satellite clinics in Victoria (800 patients registered), Kelowna (600 patients) and Prince George (250 patients). Each clinic is organized in the local Hospital under the umbrella of the local health board around a full time coordinating nurse. The UBC consultants and local neurologists work together providing high quality health care with a team of health professionals including a physiotherapist, occupational therapist and social worker. The genetic counseling team works through questionnaires from the UBC MS clinic office. In collaboration with Pharmacare and with educational funding from the pharmaceutical industry the Clinic has created the “Special Therapy” program (Dr J. Hooge chair of the Pharmacare Committee, Dr Oger Program Director) to help educate patients in the choice and management of adverse effects of disease modifying therapies (DMT). The Clinic has produced an educational videotape for “newly diagnosed patients”.
During 2003 the Clinic participated in a number of clinical trials including a trial of Copaxone on primary progressive multiple sclerosis, methods of non invasive methods of drug delivery including oral immunosuppressors Mesopram and Teriflunomide. Studies were completed on the effect of acupuncture on bladder function and on a proposed algorithm for the treatment of fatigue.
The Clinic rehabilitation team has been very active in setting-up the website of the Consortium of MS Centers (T. Jiwa), as well as participating on the Editorial Board of the journal of MS Care (J. Oger, S. Forwell). Sue Forwell of the Clinic is doing her PhD in OT at UCSF. S. Burnham has published 2 papers for the Journal of MS care and received the Silver Quill Award of the PT Association of Canada.
Dr. Helen Tremlett, published on the liver toxicity of the interferons and has been investigating the issue of stopping and switching of current medications.
Neuro-immunology Laboratories: In 2003 assays measuring antibodies to interferons were developed including ELISA for binding antibodies, MxA protein synthesis assays for neutralizing antibodies as well as bioavailabilty assays.
Genetics of MS: Dr Sadovnick a Michael Smith Distinguished Scholar received a very large grant from the MS foundation of Canada to pursue Canada-wide studies on the Genetic
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susceptibility to MS. She has also initiated a North American pregnancy registry under the auspices of the MS Consortium.
The MS/MRI Research Group, directed by Drs. Paty, Li and Traboulsee, has continued to provide internationally recognized high quality MRI analysis that has been the basis of multicentre therapeutic clinical trials. Thousands of MRI images from several major clinical trials are stored in a 4-terabyte database for future natural history studies. Innovative analysis techniques have been developed over the past year including semi-automated lesion load and brain volumetric measures and film-less activity analysis. In collaboration with the Consortium of MS Centres, Drs. Paty, Li and Traboulsee have developed international guidelines for clinical MR imaging in the diagnosis and management of Multiple Sclerosis.
The MS/MRI Research Group is a model of a successful multi-departmental program whereby neurologists, radiologists and basic scientists work together to design MRI protocols for phase II, III and IV multicenter clinical trials in multiple sclerosis. Within the past year, five new studies have been negotiated with old and new sponsors. The MS/MRI Research Group has fostered translational research in MS by supporting basic physics research, pathological correlation studies, MS COSTAR clinical database, and interaction with the MS Clinic and clinical trials group.
Neurogenetics
The UBC Neurogenetics program includes Dr. Sian Spacey, Dr. Michelle Mezei, Dr. Blair Leavitt, and genetic counselor Susan Creighton.
The UBC Neurogenetics clinic is a referral center for Neurogenetics in British Columbia. The Neurogenetics clinic provided over 300 outpatient visits in 2003. The patients seen have a wide range of inherited peripheral and central CNS disorders the most common include the ataxias, channelopathies, hereditary spastic paraparesis, the phakomatoses, myotonic dystrophy, CMT, ALS, and mitochondrial disease. Many of these patients are participants in genetic research run through the UBC Neurogenetics Unit and have donated DNA to the clinic DNA bank.
The research focus of the Clinic is on translational research. The clinic is the point of contact between the patients and basic science activity. Dr. Spacey is currently running a genome screen for the paroxysmal dystonic choreoathetosis gene while the main focus of her work is on the molecular pathogenesis of ataxia. Dr. Spacey was recently awarded an operating grant from the National Ataxia Foundation (USA) to determine how mutations in the calcium channel gene (CACNA1A) result in disease localization in the cerebellum. The BC Ataxia Foundation has recently provided funding to the UBC Neurogenetics clinic to investigate the role of antigliadin antibodies in ataxia.
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Neuromuscular Diseases Program
The provincial ALS and Myasthenia Gravis clinics continue to operate within the Neuromuscular Diseases Unit at VH. Dr. Kristine Chapman returned from a neuromuscular fellowship at Harvard, to join the neuromuscular group. Drs. Gibson and Chapman are collaborating on a myasthenia gravis project addressing the incidence of MG in the Asian population and specifically the high incidence of thymomas in this group. As well they have formalized a peripheral neuropathy clinic and are active in several diabetic neuropathy studies and a CIDP study. Quantitative sensory testing is now available in the unit for the assessment of small fibre sensory neuropathies.
Dr. Eisen, Professor Emeritus, continued in 2003 as the Director of the ALS clinic. He has just completed editing the volume “Clinical Physiology of Motor Neuron Disease” for the Handbook of Clinical Neurophysiology. He has been invited to co-edit the new volume “Motor Neuron Disorder” for the revised Handbook on Neurology and has continued to active in ALS research. Collaborative genetic studies with the University of Umea in Sweden have been very productive with the VGH clinic following the largest collection of familial ALS patients with the SOD1 mutations in North America. Therapeutic trials in ALS include an anti-apoptotic agent and a stem cell therapy trial in ALS using G-SCF stimulated homologous stem cells.
Dr. Charles Krieger’s current research focus is in the role of monocyte and microglia in the murine mouse model of ALS and in examining the role of protein kinases in denervated muscle of the murine mouse model. This work is supported by a grant from the Natural Science and Engineering Research Council of Canada. Dr. Krieger also holds a research award from the Vancouver Hospital and UBC. Dr. Michelle Mezei has been absent on maternity leave and the program is looking forward to her return.
Neuro-Oncology Program
The Neuro-Oncology program is a multidisiplinary program involving members of the Divisions of Neurology, Radiation Oncology, Neurosurgery and Medical Oncology. Its goal is to provide comprehensive care for patients with CNS malignancies and establish both clinical and translational research programs in Neuro-Oncology.
In the realm of patient care, the program has continued to supply patients with advanced surgical and radiotherapeutic management of brain tumors including a well-established linear accelerator based stereotactic radiation program. Molecular diagnostic technology has advanced our understanding of oligodendrogliomas and improved our management and chemotherapeutic strategies for these tumors.
Over the 2003 year, grant supported research into ILK inhibition in gliomas has continued with an abstract presented at the Society of Neuro-Oncology annual meeting in November, 2003. New clinical research trials were embarked upon in 2003 including a trial of Dalteparin in
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malignant gliomas. A phase 1 trial using Reovirus in glioblastoma and a phase 2 trial of Edotecarin in malignant glioma have been approved and are due to open to accrual soon.
Pacific Parkinson’s Research Centre
The Centre continues to hold a Group Grant from the CIHR, with multiple projects funded. These include studies on the Natural History and Progression of Parkinson’s Disease, Mechanisms of Fluctuations in Response to Dopaminergic Therapy, Mechanisms of and Compensatory Responses to Chronic Dopaminergic Therapy, Occupational Risk Factors and Geno-Environmental Interactions in Parkinson’s Disease, Mechanisms of ECT (Dr. Doudet) and Mechanisms of Retinal Pigmented Epithelial cell implants. The Centre performed the functional imaging for a major NIH-funded study on fetal mesencephalic transplantation for Parkinson’s disease that was published in the Annals of Neurology and had extensive collaborations with other centers in Canada, the United States, Japan and Germany, largely related to neurogenetic studies of Parkinson’s and other movement disorders.
A major achievement for the Group this year was the repatriation to Canada of Dr. Martin McKeown from Duke University. Dr. McKeown has a background in engineering physics and did his Neurology training at U. Western Ontario, followed by 3 years of postdoctoral training in computational neurobiology at the Salk Institute, in the lab of Dr. Terence Sejnowski. He was on faculty at Duke University for 5 years before coming to UBC. He brings skills in fMRI, clinical electrophysiology and the application of statistical models to the analysis of the large data sets derived from functional imaging studies.
Centre members generated 40 PubMed entries during 2003, including papers in Annals of Neurology, Biological Psychiatry, Brain, Current Opinion in Neurobiology, Journal of Cerebral Blood Flow & Metabolism, Lancet Neurology, Neuroscience and Advances in Neurology.
The backbone of the Centre’s research program continues to be the close partnership with the UBC-TRIUMF PET program. In 2003, we took delivery of a high resolution, high sensitivity human PET camera as well as a microPET device. In addition to our basic and imaging research program, a number of clinical trials continued.
The Movement Disorders Clinic continues to provide ambulatory teaching to medical students and to residents in neurology, geriatrics, psychiatry and family medicine. During the first half of 2003, there were 2 post-residency fellows working in the Clinic, from the United States and India (both have gone on to faculty positions in their home countries). In the second half of 2003, we were joined by clinical fellows from Canada (Dr. John Adams) and Brazil (Dr. Andre Troiano).
Faculty members of the Pacific Parkinson’s Research Centre participate in the Brain & Behaviour course and provide training to trainees at the MSc. and PhD. levels in the Experimental Medicine and Graduate Neuroscience programs. Dr. Stoessl ran the Motor Systems module of the Systems Neuroscience (Neuroscience 501) core course in the Graduate
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Neuroscience program. Faculty members within the Centre serve as mentors in the CIHR-funded Neuroscience Training Initiative. One of the first group of training award recipients has rotated through our centre in 2003.
The Movement Disorders Clinic provided more than 3,500 outpatient visits in 2003. The majority of these are for patients with Parkinson’s disease or focal dystonia. Patients seen in the clinic represent an enormous resource for participation in clinical trials and other, more fundamental research studies. As in other areas of the health care system, the extremely restricted availability of inpatient beds has meant that even further emphasis must be placed on outpatient care. The program is heavily supported by nurse coordinators, who provide education and counseling to patients, families and other health care professionals.
Epilepsy
The Epilepsy Program continues to provide a province wide service for BC citizens with difficult to manage seizure disorders. Dr. Michael Jones is the program director. He leads a multidisciplinary team that investigate patients who may benefit from epilepsy surgery. This program which has been established and successfully running for over 15 years with outcomes that are favourable in comparison to similar programs across North America. Dr. David Katz from Boston a well-trained young neuropsychologist has been recruited to join the multidisciplinary team. Dr. Javidan is an important contributor to the program to which Dr. Woodhurst adds his neurosurgical expertise.
Education is an important aspect of epilepsy management and the program is very active in this regard. There is support to the training and career development of both neurologists and neurosurgeons wishing to become subspecialized in the care of epilepsy.
The program has finally implemented a new state of the art EEG telemetry that is digital based, providing more degrees of freedom in terms of analyzing difficult and complex cases.
SPH Research
A number of clinical research projects are ongoing at SPH including neuroprotective studies in cerebrovascular disease, and carnitine use in HIV and AIDS related peripheral neuropathy.
Basic Neurosciences
The laboratory of Dr. Y.T. Wang has focussed on understanding the mechanisms by which the efficacy of synaptic transmission, and hence neuronal excitability, are modulated at the postsynaptic level by regulating the function of neurotransmitter receptors, in particular, the glutamate and GABAA receptors. A current lab project is to study the molecular mechanisms mediating neuronal death following stroke including the control of glutamate receptors on
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neuronal surfaces and their alteration by stroke. The main lab research focus is to develop new therapeutic agents that will interfere with cell-death inducing glutamate receptor signaling pathways by disrupting interactions of the glutamate receptors, particularly the NMDA subtype (NMDAR), with scaffolding and signaling proteins. Work in the lab has also included the novel discovery of mechanisms by which NMDA receptor activation produces neuronal apoptotic death through facilitated endocytosis of AMPA subtype of glutamate receptors. A membrane perment peptide inhibitor for this process has been developed and patent filed.
Neuropsychology Research
Over the past year the Neuropsychology Area has continued its line of research examining neurobehavioral outcome following functional and stereotactic neurosurgery for relief of intractable tremor, dyskinesia, bradykinesis, depression, obsessive-compulsive disorder and neurogenic facial pain. This research has been conducted in collaboration with Dr. Chris Honey of Neurosurgery. In 2003, funding was received from the Vancouver Hospital Foundation, Vancouver Coastal Health Authority, and Canadian Institutes of Health Research in support of this line of research. Portions of funding were used to support a Post-Doctoral Fellow in Neuropsychology. Dr. Martzke, who joined the Division of Neurology in 2002, has been the Principal Investigator for these grants. In addition, Neuropsychology has actively collaborated with Radiation Oncology at BCCA in their investigation of long-term outcome following parasellar irradiation for pituitary adenoma.
Appointments and Promotions
Dr. Doris Doudet has promoted from the rank Associate Professor to Full Professor with effect from July 1, 2003.
Special Honours and Awards
Dr. Donald Calne was appointed an honorary member of the French Neurological Society.
Dr. Doris Doudet won the 2003 Martin M. Hoffman Award for Excellence in Research by the UBC Department of Medicine.
Dr. Doris Doudet served as member, AARPT, Department of Medicine, Search Committee Head of Animal Care, MD/PHD Selection Committee, External Reviewer, National Institute of Health (NIH) – Centre for Scientific Research – BBBP1 Study Section, Member, MSFHR Biomedical Research Committee for Senior Scholar and Scientist, Member, VHHSC Interdisciplinary Research Grants Committee, Reviewer, Seed funding for Innovative Project, Faculty of Medicine, External Reviewer for CIHR – BS-B, NET Program.
Dr. Mano Javidan held the Vice Chair, Diagnostic Accreditation Committee, College of Physicians and Surgeons of British Columbia, Secretary Treasurer, Canadian Society of Clinical Neurophysiology, Member, Scientific Committee, Canadian Congress of Neurological Sciences,
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EEG Examiner, Canadian Society of Clinical Neurophysiology, Member, Board of Neurophysiology, BCIT.
Dr. Robert D. Keyes won the UBC Department of Medicine Internal Medicine Residents Teaching Award 2003. Dr. Keyes appointed Medical Review Board Member for Drug Information Reference 5th Edition, BC Drug & Poison Information Program, June 2003; Director & Board Member CBRET (Canadian Board of Registration in EEG Technology), December 2003.
Dr. Steven Pelech was the Coordinator and principal lecturer for MEDI 590, an Experimental Medicine Graduate Course focused on regulation of cell signaling mechanisms.
Dr. Lynn Raymond won the CIHR Investigator Award and Michael Smith Foundation for Health Research Senior Scholar Award through July 1, 2003 to June 30, 2008. Dr. Raymond also won the Joseph Lieberman Award from hereditary Disease Foundation, Los Angeles, CA for best operating grant in 2003: April 1, 2003 through March 31, 2005.
Dr. Gordon Robinson was the chair and convener at the Annual Forefronts in Neurology meeting for the neurologists of BC. He was also chair and convener of the Neurology Today program an annual event for family practitioners highlighting important topics in neurology.
Dr. Thomas J. Ruth won the Emeritus Award in Distinction for the service the Canadian Nuclear Medicine Community, the highest award by the Canadian Society for Nuclear Medicine, 2003.
Dr. Brian Thiessen chaired the “Molecular Diagnosis in Gliomas: a Clinician’s Perspective” session at the “Updates in Gliomas” Symposium at Lake Louise in February 2003.
Dr. Michael Varelas has been Chair of the RGH Ethics Committee since 2001.
Dr. Howard Feldman was cited by Lancet Neurology as having been author of the most popular paper published in the journal in 2003. He served on the editorial boards of Dementia and Geriatric Cognitive Disorders, the Journal of Neurological Sciences, Brain Aging, Research and Practice in Alzheimer’s Disease and International Psychogeriatrics.
Dr. Y. T Wang was awarded 3 CIHR grants in 2003 including 2 operating grants and an important Group Grant within the Brain Research Center to study synaptic structure and function.
Berlis A, Lutsep H, Barnwell S, Norbash A, Wechsler L, Jungreis CA, Woolfenden A, Redekop G, Hartmann M, Schumacher M. German Neuroradiologic Association Innovation Prize.
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PHYSICAL MEDICINE & REHABILITION
Dr. Theo van Rijn Clinical Assistant Professor & Head
Faculty Members
Clinical Associate Professor Anton, Dr. Hubert VA Clinical Associate Professor Hahn, Dr. George VA Clinical Associate Professor Schamberger, Dr. Wolfgang Burnaby Clinical Associate Professor Travlos, Dr. Andrew VA Clinical Assistant Professor Dhawan, Dr. Pankaj VA Clinical Assistant Professor Hirsch, Dr. Gabriel VA Clinical Assistant Professor Jung, Dr. Susan VA Clinical Assistant Professor Mortifee, Dr. Peter VA Clinical Assistant Professor Townson, Dr. Andrea VA Clinical Assistant Professor and Head van Rijn, Dr. Theo VA Clinical Assistant Professor Vondette, Dr. Michael VA Clinical Assistant Professor Weeks, Dr. Claire VA Clinical Instructor Adrian, Dr Mark VA Clinical Instructor Crossman, Dr. Mark Vancouver Clinical Instructor Dawson, Dr. Andrew VA Clinical Instructor Hughes, Dr. Barbara VA Clinical Instructor Koo, Dr. David VA Clinical Instructor Lau, Dr. Herman SPH Clinical Instructor Reebye, Dr. Nittin VA Clinical Instructor Underwood, Dr. Heather VA Clinical Instructor Weiss, Dr. Elliott SPH Clinical Instructor Willms, Dr. Rhonda VA Clinical Instructor Yao, Dr. Jennifer VA Honorary Professor Kaplan, Dr. Paul Associate Member Miller, Mr. William Vancouver Professor (Emeritus) Murray, Dr. Duncan Clinical Assoc Professor (Emeritus) Pinkerton, Dr. Alexander Clinical Professor (Emeritus) Robinson, Dr. Cecil
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Divisional Overview
The UBC Division of Physical Medicine & Rehabilitation currently has twenty-two active faculty members who are involved with patient care, teaching and research. Our members consult and provide rehabilitation services to persons ranging from the very young to the very old. We manage both inpatients and outpatient programs for persons who have suffered spinal cord injury, acquired brain injury, neuromuscular abnormalities and cardio/pulmonary dysfunctions. Inpatient services are provided at several sites including Vancouver Acute/GF Strong Rehab Centre, St. Paul’s Hospital, Holy Family Hospital, Eagle Ridge Hospital, Sunny Hill Health Centre as well as consultation services to the Vancouver teaching hospitals, BC Children’s Hospital, Royal Columbian Hospital and Burnaby General Hospital. Our staff is actively involved in teaching of residents and undergraduate students, as well as undergraduate students in related disciplines.
Teaching
Undergraduate: Dr. David Koo has continued to serve as the Undergraduate Coordinator. Eleven of our Division members participated in the Undergraduate curriculum including half-day lectures on disability, impairment and handicap, problem-based learning, MSK clinical skills sessions, mentorship and specialty-specific discussions on impairment and disability. Our Division continues to be actively involved in teaching elective medical students who have an interest in our specialty.
Postgraduate: Dr. Jennifer Yao is the Residency Training Director. There were seven residents in the program at the end of 2003. Program-based changes have been instituted so that all residents from PGY2 onwards obtain a formal half-day of research experience throughout their academic years. Teaching of postgraduate students is done not only at the bedside but also in more formalized seminars on an academic half-day. Residents also participate in a scheduled monthly journal club supervised by clinicians with biostatistical and/or practical clinical experience in the journal subjects chosen.
Physiatry residents were active at the Annual Department of Medicine Research Day. Many of our residents also presented at the Canadian Association of Physical Medicine and Rehabilitation Annual Meeting in June 2003.
Continuing Medical Education: Dr. Pankaj Dhawan continues to coordinate CPD activities for the Division. The Divisional website www.ubcpmr.ca provides information regarding the Division, it’s members, CPD activities, presentations (including copies of PowerPoint presentations) and useful links to journals and other websites of interest to our specialty.
2003 – 2004 CPD activities are well under way. In the last year, CanMeds topics were included routinely in weekly City Wide Rounds. Division members are being encouraged to do
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increasingly more CME through personal learning projects (PLP). The Division is currently in the process of finalizing providing CME to a facility in Jeddah, Saudi Arabia through video link. The Division’s Journal Club format has changed to better meet the perceived needs of Residents and Division members. More innovative formats ( i.e., panel discussions, controversies, experts from other subspecialties, etc.) will be introduced for this year’s City Wide Rounds. CanMeds roles are included in academic half days and Division members are not only teaching but also are encouraged to attend for own CPD activities. Dr. Dhawan extends his appreciation to the CPD Committee members and the Division as a whole for a successful year.
Faculty Presentations:
Dr. Theo van Rijn • Co-presenter at the RehabNet Conference in June 2003.
Dr. Pankaj Dhawan • Invited speaker at the 2003 College of Family Physicians Annual Conference and the WCB Annual Conference and presented on Mild Traumatic Brain Injury.
Dr. Andrea Townson • April 2003. Co-author poster presentation “A case series of cycling-related spinal cord injury” at American Spinal Injury Association Annual Meeting, Miami, Florida. • March 2003. Several poster presentations at GF Strong Research Awareness Showcase including “Research Initiatives on the Spinal Cord Injury Program” and “Effectiveness of measures to prevent person-to-person spread of urine bacteria in GF Strong Spinal Cord Injury Unit”. • June 2003. Co-investigator poster presentation “Functional Outcomes following Heroin induced acute leukoencephalopathy” Canadian Association PM and R, Edmonton, Alberta. • September 2003. Co-author presentation “SCI program at GF Strong Rehab Centre” ICORD annual general meeting, Vancouver BC. • October 2003. Co-investigator presentation “Bacteriuria in spinal cord injury” Interurban spinal cord injury conference, London, Ontario. • October 2003. International advisory board member for Rehabilitation Research and Training Centre on Secondary Prevention through Exercise: A Participatory Approach for People with Spinal Cord Injury hosted by National Rehabilitation Hospital in Washington DC and funded by NIDRR (5 year grant for $US 4 million). • December 2003. Co-investigator William Fraser Research Award from BC Rehab Foundation for “Measuring Leisure Lifestyles for Individuals with Spinal Cord Injuries”.
Dr. Hugh Anton • “Whiplash Associated Disorders from A to Z”, Columbia Health Centre, March 6, 2003. Vancouver, B.C. • “An Inventory of Soft Tissue Injuries”. The Essential Soft Tissue Injury Conference 2003, Trial Lawyers Association of British Columbia, March 28, 2003. Vancouver, B.C.
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• “What Experts Need To Know”, Annual Conference: From Retainer to Trial, Trial Lawyers Association Of B.C., December 5, 2003
Dr. David Koo • April 4-6, 2003. Poster Presenter – “A Case Series of Cycling Related Spinal Cord Injury”. American Spinal Injury Association Annual Meeting, Miami, Florida. • January 9, 2003. Department of Medicine - Orthopaedic educational half-day lecture: “Rehabilitation of the Spinal Cord Injured Patient”
Dr. Jennifer Yao • 2003 Cancer Rehabilitation: Myths and Realities 2003 – Conference organizing committee member, facilitator, and co-presenter
Resident Presentations:
Dr. Andrei Krassioukov - Invited presentations • Intraoperative EMG during complex spine surgery. William S. Keith Professorship in Neurosurgery. Toronto Western Hospital, Toronto, ON, February 2003. • Autonomic circuits after spinal cord injury: implementation for abnormal cardiovascular control in man. University of Kentucky, Lexington, KY, March 2003. • Blood pressure control in man after spinal cord injury. Guest invited speaker at the 2nd International Congress on spinal cord injury. Paris, France, May 2003. • Cardiovascular pathways in human spinal cord; histopathological examination. Guest invited speaker, International Society of Autonomic Nervous System, Satellite Meeting, “Autonomic dysfunction after spinal cord injury: mechanisms, prevention and treatment”. Banff, AB, July 2003. • Basic mechanisms of acute spinal cord injury. Guest invited speaker, “Symposium on Spinal Cord Injury and Rehabilitation: Research-Practice”. Toronto, ON, September 26 2003. • Abnormal cardiovascular control and timing of surgical decompression in acute cervical spinal cord injury. Cervical Spine Research Society. Scottsdale, AZ, USA. December 2003. • Blood pressure control in acute spinal cord injury in human. Neuroscience Rounds, VGH, UBC, Vancouver, BC, November 2003.
Dr. Heather Finlayson • “Severe Complex Regional Pain Syndrome Type 1 Managed with Amputation: A Case Study”. Internal Department of Medicine Annual Resident Research Day.
Dr. Jacqueline Purtzki • Presented Research Paper on Cerebral Palsy: transition from adolescence to adulthood at the UBC Resident Research Day.
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• Co-investigator poster presentation “Functional Outcomes following Heroin induced acute leukoencephalopathy” Canadian Association PM and R, Edmonton, Alberta.
Research
Faculty Research: We are committed to enhancing the quality and quantity of research in our Division. Dr. Hugh Anton is the Division Research Coordinator and was appointed Chair of the new Division Research Advisory Committee. Other members include Dr. Drew Dawson, Dr. Andrea Townson and Dr. Elliott Weiss. The Division recruited a Research Nurse Coordinator in 2003 who has been involved with several industry funded research projects. A monthly seminar on research has been implemented at the G.F. Strong Rehab Centre to facilitate the involvement of Division members in research. Research was one of the themes of the most recent Division Retreat in November 2003 and a number of promising research questions were developed.
The Division of Physical Medicine & Rehabilitation & the UBC School of Rehabilitation Sciences co-hosted a successful event during the UBC Research Awareness Week. Many Division members participated with poster presentations at this event as well several other conferences & annual meetings throughout the year.
Resident Research: Dr. Andrei Krassioukov who is currently a PGY2 Resident investigator has continued on with his research established before joining the program in July of 2003. He is currently working as the Principle Investigator on “The Fate of Sympathetic Preganglyonic Neurons after SCI" (Christopher Reeve Paralysis Foundation); Principle Investigator: Plasticity in Spinal Autonomic Circuits of Humans after Spinal Cord Injury (Heart & Stroke Foundation) and Co-Principle Investigator: Autonomic Dysreflexia in men during sperm retrieval procedures (BC Neurotrauma Fund.
Clinical Services / Administration
Members of our Division provide consultative services to Vancouver Acute, UBC Hospital and St. Paul’s Hospital. They serve as facilitators for admission from other areas of the province for individuals who require services of a more specialized rehabilitation facility.
Drs. Pankaj Dhawan, Andrea Townson and Andrew Travlos currently serve as Rehabilitation Medical Managers assisting in program-related issues in development of new programs within GF Strong Rehab Centre and associated facilities. Dr. Elliott Weiss is the Physician Operations Leader, Rehabilitation, Providence Health Care and Division Head, PM&R, Department of Medicine, Providence Health Care.
Dr. Pankaj Dhawan has assisted in developing the Early Intervention Program for persons with mild traumatic brain injury, providing care for some of those individuals who have been
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identified as having suffered a recent injury when seen in one of the local emergency departments. He has also been involved in developing a self-management program for persons with chronic mild traumatic brain injury.
Dr. Andrew Travlos and team members at GF Strong Rehab Centre provide clinical services and assistance to persons suffering from Amyotrophic Lateral Sclerosis.
Dr. Rhonda Willms and Dr. Heather Underwood at GF Strong Rehab Centre and Dr. Weiss at Holy Family Hospital participate in inpatient and/or outpatient services for persons who require orthotics and/or prosthetics services.
Dr. George Hahn continues to provide consultation services at BC Children’s Hospital, Vancouver Acute, inpatient and outpatient services for the Adolescent/Young Adult Service and provides rehabilitation direction at Sunny Hill Health Centre.
Future Directions
Our members have been actively involved with establishing relevant research themes and exploring funding opportunities to develop such projects. We are actively involved in developing an overseas continuing medical education program. We are involved in expanding the Interdisciplinary ALS program, which will continue to evolve out of GF Strong. We will be assisting in the development of the rehabilitation component of the 5th World Stroke Congress to be held in Vancouver in June of 2004. We continue to work closely with the Department of Medicine training some of the future teachers for the medical school expansion program at UBC. The Division will also be exploring possible joint training and/or research initiatives with Occupational Health, and the Spine Program of Vancouver Acute. We are also assisting in developing best practices for stroke care.
Appointments & Promotions
Dr. Andrew Travlos was appointed as Clinical Associate Professor from August 8, 2003. Dr. Mark Crossman recently joined the Division and was appointed Clinical Instructor effective December 2003. Dr. William Miller was appointed as associate member of the Division in 2003.
Special Honors and Awards Faculty:
Dr. Pankaj Dhawan was awarded a Certificate of Merit in Clinical Skills by the Dean’s Office, UBC Faculty of Medicine, for his outstanding contribution in teaching the Clinical Skills program.
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Dr. Heather Underwood was awarded the Dr. Duncan Murray Teaching Award for Teaching Excellence by the Residents of the UBC Division of Physical Medicine & Rehabilitation Residency Program.
Dr. Andrea Townson and co-researchers was awarded one of three $15,000 2003 William Fraser Research Awards sponsored by the BC Rehab Foundation for their research project “The Psychometric Properties of the ISYLL ARBOR Leisure Battery Among Individuals with a Spinal Cord Injury”.
Dr. Andrew Dawson and co-researchers was awarded one of three $15,000 William Fraser Research Awards sponsored by the BC Rehab Foundation for their research project “Cardiovascular Fitness in Acute Stroke Patients”.
Dr. Andrew Travlos and the ALS Team at GF Strong Rehab Centre along with the Vancouver Hospital ALS Clinic & ALS Society of BC were awarded the “Exceptional Support Services Award” by the ALS Society of Canada. The team was commended for their excellence in support services to those affected by ALS and for their model of cooperative leadership.
Residents:
Dr. Andrei Krassioukov (Resident PGY2) was awarded “the best manuscript in the area of spinal cord injury published in 2003 award” from the American Spinal Cord Injury Association (ASIA) in May 2003 for the following publication: Krassioukov, A., D.G. Johns and L.P. Schramm. Sensitivity of Sympathetically correlated spinal Interneurons, Renal Sympathetic Nerve Activity, and Arterial Pressure to Somatic and Visceral Stimuli after Chronic Spinal Injury. J. Neurotrauma, 19(12): 1521-1529, 2002.
Dr. Heather Finlayson (Resident PGY2) awarded a certificate for “best oral presentation by an R2” at the Internal Department of Medicine Annual Resident Research Day.
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RESPIRATORY MEDICINE
Dr. John Fleetham Professor and Head
Faculty Members
Professor and Head Fleetham, Dr John VA Professor Bai, Dr. Tony SPH Professor Duronio, Dr. Vincent VA Professor FitzGerald, Dr. J. Mark VA Professor Lam, Dr. Stephen VA Professor Ostrow, Dr. David VA Professor Pare, Dr. Peter SPH Professor Road, Dr. Jeremy VA Professor Yeung, Dr. Moira VA Associate Professor Khalil, Dr. Nasreen BCCDC Associate Professor Levy, Dr. Robert SPH Associate Professor Ryan, Dr. Francis (Frank) VA Associate Professor Van Eeden, Dr. Stephan SPH Associate Professor Ward, Dr. Helen VA Associate Professor Wilcox, Dr. Pearce SPH Assistant Professor Ayas, Dr. Najib VA Assistant Professor Sandford, Dr. Andrew SPH Clinical Professor Champion, Dr. Paul VA Clinical Professor Lawson, Dr. Lindsay SPH Clinical Associate Professor Elwood, Dr. Richard BCCDC Clinical Associate Professor Nakielna, Dr. Barbara Edina SPH Clinical Assistant Professor Fera, Dr. Tharwat VA Clinical Assistant Professor Turner, Dr. Mark VA Clinical Instructor Wilson, Dr. Jennifer VA Honorary Professor Lertzman, Dr. Morley Honorary Professor Tan-Hogg, Dr. Wan Vancouver Associate Member Brauer, Dr. Michael Vancouver Associate Member Lowe, Dr. Alan Vancouver Associate Member Muller, Dr. Nestor Associate Member Roberts, Dr. Clive Vancouver Professor (Emeritus) Abboud, Dr. Raja VA Clinical Professor (Emeritus) Allen, Dr. Edward
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Professor (Emeritus) Bates, Dr. David
Divisional Overview
The UBC Respiratory Division consists of 31 faculty members who are located at Vancouver Acute (Vancouver General Hospital, UBC Hospital), Providence Health Care (St. Paul’s Hospital, Mt. St. Joseph Hospital) Vancouver Cancer Centre, BC Centre for Disease Control and BC Transplant Society. There are active respiratory medicine in-patient and ambulatory care programs at Vancouver General Hospital and St. Paul’s Hospital. The two-year subspecialty respiratory medicine training program accepts one provincially funded trainee per year. Respiratory Medicine is considered a centre of research excellence at both Providence Health Care and Vancouver Acute. Respiratory Medicine is a major component in the iCapture Centre primarily based at St. Paul’s Hospital. Respiratory Medicine is the primary component of the Lung and Critical Care Research Program at Vancouver Coastal Health Institute. The UBC Respiratory Division is developing a strategic plan for clinical care, research and teaching of Respiratory Medicine within the Vancouver Coastal Health Authority, which incorporates an academic funding contract for all divisional members. Drs. Tan Hogg and Sin joined the Division in late 2003 and are both based at St. Paul’s Hospital. Dr. P. Man has been appointed Head of Medicine, Providence Health Care March 1st 2004, and will also be a member of the UBC Respiratory Division.
Teaching
Undergraduate: The UBC Respiratory Division continues to have a major responsibility for the five-week pulmonary block in the undergraduate curriculum. Dr. F. Ryan continues as chair of the pulmonary block. Division members participate in undergraduate teaching either as tutors or clinical skills instructors.
Postgraduate: The UBC Respiratory Medicine Training Program, directed by Dr. P. Wilcox, continues to attract a large number of highly qualified applicants from across Canada. The program has full approval from the Royal College. This two year clinical program is based at both Vancouver General Hospital and St. Paul's Hospital. There are elective opportunities at community-based centres throughout BC and the program offers an optional third year of research training. Our current trainees are Dr. W. Davidson (Vancouver), Dr. M. Al Bader (Kuwait), Dr. F. Al Enezi (Kuwait), Dr. G. Alvarez (Ottawa), Dr. M. Al Ajmi (Kuwait), Dr. T. Shaipanich (Thailand), Dr.Tae Won Shin (Edmonton), Dr. J. Swiston (Vancouver). The UBC Respiratory Division proposes to expand the number of trainees from one to two per year and to offer a three year combined fellowship program in Respiratory Medicine/ICU.
Experimental Medicine: The UBC Respiratory Division continues to make significant contributions to the Departmental Experimental Medicine program with MSc. and PhD students being trained in both the Jack Bell Research Laboratory at Vancouver General Hospital and the iCapture Centre at St. Paul's Hospital.
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Continuing Medical Education: Dr. Mark FitzGerald is primarily responsible for continuing medical education within the UBC Respiratory Division and organizes a three day annual international CME course on critical care and respiratory medicine in spring at Whistler. A weekly research seminar series for the UBC respiratory community is held between September- May. Division members are very active in CME in a large variety of provincial, national and international forums.
Research
Respiratory Medicine is considered a centre of research excellence at both Providence Health Care and Vancouver Acute. Respiratory Medicine is a major component in the iCapture Centre primarily based at St. Paul’s Hospital. Respiratory Medicine is the primary component of the Lung and Critical Care Research Program at Vancouver Coastal Health Institute (VCHI). The iCapture Centre was created with CFI funds to examine how abnormal genes change the structure and function of cells, tissues and organs to cause lung disease. The major respiratory medicine research interests at the VCHI Lung and Critical Care Research Program are respiratory sleep and neuromuscular disease, environmental and occupational lung disease and emphysema. The prevention and early diagnosis of lung cancer is the primary research focus at the Vancouver Cancer Centre and research into tuberculosis and mycobacterial disease is the major interest at the BC Centre for Disease Control. Research in lung transplantation takes place at both Vancouver Acute and the BC Transplant Society.
Clinical Services
Active respiratory medicine in-patient and ambulatory care programs continue at both Vancouver General Hospital and St. Paul's Hospital. Ambulatory care space has been developed within St. Paul’s Hospital for the members of the St. Paul’s Hospital Respiratory Division. The respiratory inpatient beds at Vancouver General Hospital moved to a combined 40 bed Respiratory Medicine/Thoracic Surgery ward in the 12th floor of the J. Pattison Tower on June 2003.
Administration
Dr. John Fleetham is the Head of the UBC and Vancouver Acute Respiratory Divisions. Dr. Robert Levy is Head of the Providence Health Care Respiratory Division. Bernice Robillard continues to work to support the administrative activities of the UBC Respiratory Division with major responsibilities for the postgraduate program.
Future Directions
The UBC Respiratory Division proposes to develop a strategic plan for clinical care, research and teaching of Respiratory Medicine within the Vancouver Coastal Health Authority, which incorporates an academic funding contract for all divisional members.
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Special Honours and Awards
Dr. Nasreen Khalil was awarded the Roche Oncology Award for excellent in Clinical Skills Teaching. Dr. Moira Chan-Yeung was selected as the 2003 Canadian Thoracic Society Christie Memorial Lecturer. Dr. Donald Sin was appointed Glaxo-Smith-Kline/St. Paul’s Hospital Foundation Professorship in COPD. Dr. Vincent Duronio was promoted to Professor of Medicine.
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RHEUMATOLOGY
Dr. John M. Esdaile Professor & Head
Faculty Members
Professor and Head Esdaile, Dr. John VA Professor Chalmers, Dr. Andrew VA Assistant Professor Lacaille, Dr. Diane VA Clinical Professor Blocka, Dr. Kenneth VA Clinical Professor Koehler, Dr. Barry Richmond General Clinical Professor Tsang, Dr. Ian VA Clinical Associate Professor Huang, Dr. Simon SPH Clinical Associate Professor Patterson, Dr. A. Caroline VA Clinical Associate Professor Reid, Dr. Graham VA Clinical Associate Professor Wade, Dr. John VA Clinical Assistant Professor Ensworth, Dr. Stephanie VA Clinical Assistant Professor Kelsall, Dr. John SPH Clinical Assistant Professor Klinkhoff, Dr. Alice VA Clinical Assistant Professor Shojania, Dr. Kamran VA Clinical Assistant Professor Shuckett, Dr. Rhonda SPH Clinical Instructor Fenton, Dr. Stanley RCH Clinical Instructor Gillies, Dr. Jean SPH Clinical Instructor Watterson, Dr. John VA Honorary Professor Stein, Dr. Howard SPH Visitor Pouchot, Dr. Jacques Vancouver Professor (Emeritus) Ford, Dr. Denys Clinical Professor (Emeritus) Robinson, Dr. Harold
Divisional Overview
Seventeen faculty form the UBC Division of Rheumatology. They are located at Vancouver Hospital and Health Sciences Centre, St. Paul’s Hospital, G.F. Strong Rehabilitation Centre, and the B.C. Women’s Hospital and Health Centre.
The two-year Postgraduate Training Program in Rheumatology is currently the second-largest clinical rheumatology training centre in Canada. There are 6 trainees, including Ministry funded residents, those funded by The Arthritis Society of Canada and international trainees.
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Many divisional faculty are members of the Arthritis Research Centre of Canada, a multidisciplinary clinical research and clinical trials facility which includes faculty from Rheumatology, Orthopaedics, Epidemiology and Health Care and the School of Rehabilitation Sciences. The centre focuses on "Practical Research for Everyday Living" for people with arthritis.
Dr. Ian Tsang, a member of the Division since 1986, retired from the University this year. Dr. Tsang was Chief of Staff at the Holy Family Hospital for almost a decade and served as Head of the Division of Rheumatology at the Shaughnessy Hospital. From 1992-1993, he served as Head of the Division of Rheumatology and the Rheumatic Disease Unit at UBC. From 1989-90, he was Associate Dean of Continuing Medical Education. In the 1990’s, with funding from the National Aeronautics and Space Agency, Dr. Tsang performed pioneering research on the topic of low back pain in the microgravity state. He is one of the few physicians to have been appointed a Governing Director of the National Research Council of Canada where he served for two terms. He also served on the National Research Council’s Advisory Board and the Executive Committee. He continues as the Director of the Division of Traditional Chinese Medicine Research at the Arthritis Research Centre of Canada and as a consultant rheumatologist.
Teaching
Dr. Simon Hunag continues to direct undergraduate teaching. The Patient Partners program led by Dr. Ken Blocka is to be a valuable component to undergraduate teaching and is now being used successfully at St. Paul’s Hospital to train internal medicine residents. The Vancouver Hospital will adopt a similar program in 2004.
Two years ago, Dr. Kam Shojania developed a website (www.rheumweb.com) designed to provide undergraduate students with a way to learn more about the rheumatology program. The website provides information on rheumatology, rheumatology rotations, and rheumatology research. Other Canadian academic rheumatology programs have expressed interest in developing similar websites.
The postgraduate program continues to be led by Drs. Kenneth Blocka, Graham Reid and John Esdaile at SPH, GF Strong and VHHSC, respectively. The postgraduate program includes two first-year fellows, three second-year fellows, a third year clinical fellow, one Masters candidate and two doctoral candidates. The clinical trainees have been involved in outreach clinics in Trail, Cranbrook, Fort St. John and other rural communities throughout B.C. Both the UBC and The Arthritis Society (BC & Yukon Division) provided support for travel and accommodation for these outreach clinics.
For the third year, a basics skills course for rheumatology fellows was given in the first week of July to provide detailed instruction on the clinical examination of the musculoskeletal exam, as well as the essentials of emergency arthritis care. The course was organized by Dr. Kam Shojania and involved the majority of the divisional faculty.
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As part of a third clinical year, Dr. Hani Al Moallim is completing a certificate in medical education. He has developed a variety of new clinical teaching activities including a clinic specifically for internal medicine residents and another for second year rheumatology residents.
Dr. Howard Stein continues to volunteer his time teaching the clinical fellows every week at the weekly Academic Half-day. The postgraduate program has also benefited from a number of visiting professors including, James Seibold (Robert Wood Johnson Medical School), John Davis (University of California, San Francisco), Ray Sinatra (Yale University) and Jerry Tenenbaum (University of Toronto).
Research
Members of the Division have been active in the Arthritis Research Centre of Canada. The centre includes faculty from the Division of Rheumatology, the Department of Orthopedics, the Department of Epidemiology and Health Care, and the School of Rehabilitation Sciences, as well as from the Centre for Health Evaluation and Outcome Studies at St. Paul’s Hospital. In 2003, the Arthritis Research Centre received notification of about $1,600,000 in funding from peer- review agencies. Drs. John Esdaile, Diane Lacaille, as well as other members of the centre were awarded a New Emerging Team grant from the CIHR. This five-year project brings together a large group of researchers from across Canada to study early osteoarthritis.
Drs. Blocka, Chalmers, Dutz, Ensworth, Huang, Kelsall, Klinkhoff, Shojania and Stein continue to study novel modalities for persons with arthritis in BC. Dr. Shojania was appointed a Director of the Canadian Rheumatology Research Consortium, a newly-formed group that will expand Canada’s presence in international arthritis clinical trials.
Dr. Esdaile was the Pfizer Visiting Professor of Clinical Research at Emory University.
Professor Jacques Pouchot is on sabbatical leave in the Division as a Visiting Professor from Hopital Mourier, Paris, France.
Clinical Services
The Mary Pack Arthritis Program, a Vancouver Hospital-based treatment program, is led by Dr. Alice Klinkhoff. Many VGH and St. Paul’s faculty provide ambulatory care in the Program’s outpatient drug and disease monitoring clinics, as well as traveling to 28 rural locations to provide consultation services. This year, Dr. John Kelsall has added a new traveling consultation service to New Aiyansh at the Nisga’a Valley Health Centre. Dr. Bruce Blasberg, Professor of Dentistry, UBC, has started an Oral Pathology Clinic to treat persons with temporomandibular joint disorders.
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Special Honours and Awards
Dr. Jolanda Cibere received a CIHR Clinician Scientist Fellowship Award Phase II to continue her doctoral studies on osteoarthritis.
Dr. Kamran Shojania received the Clinical Faculty Award for Excellence in Teaching, one of only three awarded annually by the University.
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EDUCATIONAL PROGRAMS
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CONTINUING MEDICAL EDUCATION PROGRAM
Dr. Graydon S. Meneilly Interim Director
New Initiatives/Developments
The main initiative for 2003 was our “Medicine in the 21st Century” Conference held June 5th – 7th at the Sutton Place Hotel. Thirty-five UBC Faculty participated in the course which was presented to 98 attendees primarily from Canada and the United States.
As in past years, we were pleased with the attendance and quality of the course. Once again, the speakers were evaluated highly as was the course content. It is our hope and intention to continue to offer this course on an annual basis and to maintain the high quality as well as to continue increasing attendance.
We are currently in the process of coordinating our 2004 program which is scheduled to be held June 10 – 12, 2004 at the Sutton Place Hotel in downtown Vancouver. This year, for the first time, we are offering a post-conference CME Program in the form of an Alaska Cruise which is to take place June 13 – 20th immediately following the main event. We have been fortunate to recruit excellent speakers who will be participating in this event. They include Dr. Jerry Tenenbaum of the University of Toronto, Dr. Lucretia van den Berg founder of the Victoria Womens’ Health Centre, Dr. Najib Ayas a Respirologist with UBC and Dr. Hector Baillie, a General Internist from Nanaimo. We are looking forward to a successful outcome from this event.
Dr. G.B. John Mancini has agreed to take on the role of CME Director and will be working directly with Hazel Wilcox in the development of new programs for the upcoming year. In 2004 we would like to begin to work on development of further program divisional events and will be actively meeting with Division Heads to help work towards this goal.
We would like to take this opportunity to thank the Faculty Members who have contributed to the conference in the past years and continue to work with the Department to help ensure excellent ongoing CME programs.
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HIV/AIDS RESEARCH PROGRAM
Dr. Julio Montaner Professor and Director
Divisional Overview
The AIDS Research Program continues to focus on further defining the role of antiretroviral therapy for the treatment of HIV infection. The main areas of research continue to be epidemiology, basic science and clinical science. Below is a summary of some of the program's activities and areas of concern for the year 2003.
Epidemiological Research
The epidemiology group has remained highly productive during this year. The Program continues to benefit from long-term analysis emerging from the VanGuard Project, the VIDUS and CEDAR cohorts under the leadership of Drs. Lampinen, Wood and Spittal, respectively. The VIDUS project published 21 peer-reviewed research papers in 2003. The Drug Treatment Program, under the leadership of Dr. Robert Hogg, has emerged as a key contributor to our understanding of the dynamics of the HIV epidemic as well as the impact of treatment. Several key papers were published demonstrating the impact of antiretroviral therapy in terms of decreasing morbidity, mortality, and quality of life in HIV-infected individuals, many of them in highly respected international journals. Members of our team have received funding from the Michael Smith Health Research Foundation and the Canadian Institutes of Health Research for doctoral and post-doctoral training. These include Paula Braitstein, Zabrina Brumme, Tom Lampinen, Cari Miller, Magda Piacenza, Amy Weber, Melanie Rusch and Laura Kuyper. Grant funding has also been obtained by members of our group from the Michael Smith Health Research Foundation, Canadian Institutes of Health Research, the Ontario HIV Treatment Network, and a number of pharmaceutical companies.
Basic Science
The research laboratory based at the B. C. Centre for Excellence in HIV/AIDS has established itself as a leading force in Canada with international influence. During the year, the laboratory provided clinical services to the province of B. C. in the areas of HIV drug resistance testing and pharmacokinetic measurement. HIV drug resistance testing services are also offered on a Canada-wide basis and as part of clinical trials. The clinical implications and predictors of HIV drug resistance continue to be investigated, both at the B.C. Centre for Excellence and as part of international collaborations. The research laboratory also is continuing to develop new tools, which may be clinically applied in the near future. These include tools for monitoring the side-
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effects and degree of adherence to medications, as well as variations in the HIV and human genomes which are associated with response to HIV therapy.
In 2003, members of the lab published more than 10 important research papers, in peer-reviewed journals including Annals of Internal Medicine, Journal of Infectious Disease, and AIDS.
Clinical Science
The clinical science group has focused their efforts on a number of broad areas relevant to the clinical management of patients with HIV. These are salvage therapy, adherence, toxicities, novel treatment strategies, and viral co-infections.
Optimal therapy for patients who have experienced failure on a number of previous antiretroviral treatment regimens continues to present a major challenge. The clinical group has been refining their previous work in the use of multiple drug rescue therapy (MDRT) in treating these patients. This strategy has been enhanced with the addition of newly available agents such as the fusion inhibitor enfuvirtide. In addition, the complex pharmacokinetic interactions between the agents in these MDRT regimens are being studied by intensive therapeutic drug monitoring which is performed at our centre, using assays developed at the BC Centre for Excellence laboratory.
In association with two clinical psychologists, a number of studies have been completed or are ongoing to address the issues of adherence to antiretroviral drug regimens. Factors which are associated with successful therapy, as well as factors which impede optimal adherence have been assessed. Work is underway to develop a tool to assess patients’ readiness and motivation to start antiretroviral medication, with the aim of designing effective interventions to be applied in the clinic setting.
Side effects of antiretroviral therapy continue to be an important focus of the clinical research team. The mitochondrial DNA assay is being used extensively to help elucidate the mechanisms of mitochondrial toxicity of nucleoside reverse transcriptase inhibitors, and help gain a better understanding of effective interventions. Newly recognized toxicities of newer agents such as tenofovir have also been addressed in detail, through a large cohort of patients who are followed closely while taking these drugs. In association with colleagues from the Healthy Heart Program, patients with lipid disorders related to HIV and antiretroviral medications undergo intensive assessment by a team including a lipid specialist and a nutritionist. A number of studies are currently underway to evaluate management of HIV patients with dyslipidemias and other metabolic disorders.
A number of strategies used to manage HIV treatment in the clinic are being formally evaluated by the clinical team. For example, a large number of patients are undergoing treatment interruptions and are being carefully evaluated for their short and long-term outcomes. Another example is the use of novel nucleoside-sparing regimens, aimed at avoiding the toxicities associated with nucleoside reverse transcriptase inhibitors, which is being studied in an international clinical trial, coordinated locally.
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Viral co-infections with hepatitis B and C continue to be a major problem in the HIV-infected clinic population. The clinical group is actively involved in a number of studies examining new treatments for viral hepatitis in this setting.
In 2003, the John Ruedy Immunodeficiency Clinic reopened as a primary and specialty clinic for HIV infected patients. The clinical team includes individuals with expertise in all areas of HIV care with special emphasis on primary care, infectious diseases, respiratory medicine, lipid disorders, anal dysplasia, neurology, dermatology, counseling and psychology, palliative care, and clinical trial operations.
The clinic, in partnership with the Vancouver Coastal Health Authority, also offers a 3-month post graduate program for family doctors. It’s objective is to enhance skills in the care and treatment of patients with HIV/AIDS. An Antiretroviral Outreach Program (ARV-ORO) was also established to help inform, support and evaluate activities in Vancouver's Downtown Eastside.
Current Areas of Active Research
• First-line antiretroviral therapy • Salvage therapy for patients with previous treatment failure, including multiple drug rescue therapy • Impact of treatment interruptions • Complications of antiretroviral therapy, including lipodystrophy, dyslipidemias, cardiovascular disease, mitochondrial toxicity, peripheral neuropathy, hepatotoxicity, nephrotoxicity • Assessing and optimizing adherence to antiretroviral regimens • Pharmacokinetics of antiretroviral drugs • Treatment of co-infections with HIV and hepatitis B/C • Prevention and treatment of opportunistic infections
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Students/Residents/Postdoctoral Research Fellows:
Student name Program Type Dates Supervisor
Braitstein, P. PhD, UBC 1999-Present R. Hogg
Craib, K. PhD, UBC 1997-Present M. Schechter
Cuscheri, A. PhD, UBC 2002-Present M. Tyndall, R. Hogg
Rusch, M PhD, UBC 2002-Present M. Tyndall
Weber, A. MD/PhD, UBC 2002-Present M. Tyndall
Heath, K. Post-Doc 2003 J. Montaner
Lampinen, T. Post-Doc 2002-Present R. Hogg
Green, T. MSc 2001-03
Wong, K.H. Visiting Scientist, 2003 Hong Kong
Piaseczna, M. MSc 2001-2003 M. Schechter, MSHRF R. Hogg
Brumme, Z. (Exp medicine) PhD 2001-present R. Hogg, J. Montaner MSHRF, CIHR
Christie, T. MSc 2003 R. Hogg, J. Montaner
Remple, V. Health Care & 2003 Epidemiology MD/PhD Penner, J. Health Care & 2003 Epidemiology, M.S. Thesis Student Corneil, T. Medical Resident Aug-Nov, 2003 R. Hogg/E. Wood
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Student name Program Type Dates Supervisor
Jain, J. Farrow, H. Chung, Residents 2003 J. Montaner A. Jaber, A. Buzaid, N. Esmail, K. Al Gofaili, D. Liu, S. Perlman, J. Trip, D. Thomas, F. Harji, A. Sadia, G. Medvedev, M. Lysyshyn, K. Gupta, L. Al Riyami, J. Shah, Abufayah, Mohammed, T Szakacs
ANametallah, J. Wu, R. Fellows 2003 J. Montaner Lester, K. Chan
Zala, C. Visiting Doctor 2003 J. Montaner
Alvarez, G. Visiting Doctor 2003 J. Montaner
Mohammed, R. Visiting Doctor 2003 J. Montaner
Forrest, D. Visiting Doctor 2003 J. Montaner
Burns, M. Visiting Doctor 2003 J. Montaner (IDC Preceptorship)
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GRADUATE STUDIES PROGRAM IN EXPERIMENTAL MEDICINE
Dr. Norman L. M. Wong Professor and Director
Divisional Overview
Experimental medicine is the graduate studies program, within the Department of Medicine, which was developed to train individuals seeking a career in medical research. Students are enrolled in both MSc and PhD degree programs. Subspecialties within the Experimental Medicine Program include Cancer Biology, Cardiology, Dermatology, Gastroenterology, Haematology/Oncology, Immunology, Infectious Diseases, Molecular Biology, Nephrology, Neurology, Pediatrics, Physiotherapy and Respiratory Medicine. In 2003, 26 new students were admitted to the program. At the end of 2003, there were 103 students registered in the program, 52 for MSc degrees and 51 for PhD degrees.
During 2003, a total of twelve students graduated, five at the May 2003 Convocation and seven at the November 2003 Convocation. Student names and thesis titles are listed below (research supervisor in parenthesis):
PhD Graduates
1. Ali Behzad, Regulation of Inflammatory and Fibrotic Mediators by Adenovirus E1A in Guinea Pig Lung Cells, (Dr. James Hogg) 2. K. John Cheung, Expression Profile and Molecular Functions of the Tumor Suppresor p33ING1, (Dr. Gang Li) 3. Steven Drews, Molecular Characterization of Mycobacterium Tuberculosis PKNB, (Dr. Yossef Av-Gay) 4. Annette Ehrhardt, Analysis of activation of different Ras family members by hematopietic growth factors and antigen receptors, (Dr. John Schrader) 5. Robert Gerl, Heat shock-induced signal transduction in hematopoietic cells, (Dr. John Schrader) 6. Brock Grill, Molecular Mechanisms of Cellular Activation (Dr. John Schrader) 7. Janet Kalesnikoff, Regulation of Mast Cell Activation, (Dr. Gerald Krystal)
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MSc Graduates
1. Roopjeet Kahlon, The Role of Cholera Toxin and Tape Stripping in Epicutaneous Immunization, (Dr. Jan Dutz) 2. Yvonne Luu, Molecular mechanisms of tumour suppression by the p53-stabilizing compound CP-31398, (Dr. Gang Li) 3. Graeme McLean, Notch activation induces an endothelian-to-mesenchymal transformation, (Dr. Aly Karsan) 4. Farnoosh Tayyari, Interventions for primary prevention of post-bronchiolitis allergic sensitization in guinea pigs, (Dr. Richard Hegele) 5. Theresa Wiens, Development of liposome formulations of ethambutol, rifampicin, and isoniazid for pulmonary treatment of tuberculosis, (Dr. Yossef Av-Gay)
Janet Kalesnikoff was awarded the Governor General’s Gold Medal for the best PhD thesis defended at UBC during the 2002-2003 academic year.
In 2003, 79 Experimental Medicine students received a total of $1,519,630 in funding, an average of $19,235 per student. Research Supervisors provided $780,300 in Graduate Research Assistantships. Other funding sources included CIHR ($260,500), the Michael Smith Foundation ($142,000), NSERC ($77,000), the BC Science Council ($40,000), and the UBC Graduate Entrance Scholarship ($18,000).
There are 104 faculty members currently registered as Research Supervisors in the program. Faculty members from other departments also participate as course lecturers, thesis committee members, in research seminars and as examiners for internal examinations and theses defenses.
In the academic year 2003, the Experimental Medicine Program offered nine graduate courses. These included: MEDI 501 (Molecular & Cellular Biology), MEDI 502 (Methodology), MEDI 530 (Gastroenterology) MEDI 535 (Journal Club), MEDI 548 (Directed Studies in Experimental Medicine), MEDI 560 (Pulmonary Pathophysiology), MEDI 570 (Cardiology), MEDI 580 (Infectious Diseases) and MEDI 590 (Molecular Medicine).
The overall administration of the program is under the guidance of the Experimental Medicine Committee. The committee is composed of representatives from each subspecialty and one student representative. This committee meets four times per year to discuss policy and procedures. Current members of the committee are: Dr. Anthony Chow (Infectious Diseases), Dr. Vince Duronio (Respiratory Medicine), Dr. Keith Humphries (Haematology/Oncology), Dr. Gang Li (Dermatology), Dr. Steve Pelech (Molecular Medicine), Dr. Bill Salh (Gastroenterology), Dr. Joseph Tsui (Neurology), Ms. Alison Wallace (Student Representative), Dr. Keith Walley (Respiratory Medicine), Dr. Norman Wong (Nephrology and Director) and Dr.
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Graydon Meneilly (ex-officio). The Experimental Medicine Program’s daily administration is through the director and one secretary.
The Experimental Medicine Program continues to sponsor an annual Student Research Day. The event was held on Thursday, October 30 at the Plaza 500 Hotel. 16 students gave oral presentations and 39 students participated in poster presentations. A total of $700 in cash prizes was presented this year. Each award recipient also received a plaque. The prizes this year went to:
Zabrina Brumme (PhD, Supervisor: Dr. Richard Harrigan) - $300 Best Overall Presentation Amanda Rooyakkers (MSc, Supervisor: Dr. Richard Stokes) - $100 Best Oral Presentation Shirin Kalyan (PhD, Supervisor: Dr. Anthony W. Chow) - $100 Best Oral Presentation Alexander Scott (PhD, Supervisor: Dr. Vincent Duronio) - $100 Best Poster Presentation Kevin Leong (PhD, Supervisor: Dr. Aly Karsan) - $100 Best Poster Presentation
Financial support for Student Research Day was provided by GlaxoSmithKline Inc., Merck Frosst Canada Inc. and the Vancouver Hospital and Health Sciences Centre.
Zabrina Brumme was awarded an Honorary Killam Predoctoral Fellowship in 2003, one of 17 such awards given to UBC graduate students. Killam Predoctoral Fellowships are the most prestigious awards available to graduate students at UBC.
The Experimental Medicine Program continued to offer travel grants to students who had already used the travel grant provided by the Faculty of Graduate Studies.
The Experimental Medicine Office is located in Room S154, Koerner Pavilion, 2211 Wesbrook Mall, UBC Campus. The office telephone number is 604-822-7215, the fax number is 604-822- 7897 and e-mail address is [email protected].
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POSTGRADUATE EDUCATION PROGRAM
Dr. Iain Mackie Clinical Professor & Director
Postgraduate Medical Education
New Initiatives/Developments
There were a number of events that highlighted 2003 for the Internal Medical Residency Training Program. The first and foremost would be receiving Full Program Accreditation in June from the Royal College of Physicians & Surgeons of Canada. The Program had been previously on provisional accreditation for two years and receiving full accreditation was the culmination of two years of effort and hard work by the Postgraduate Education Committee.
In January 2003 the Residency Program was no longer able to provide residents to cover CTUs at the UBC Hospital Site. In January residents set to attend CTU at UBC during the second half of the academic year were redistributed to a newly developed CTU Triage at both St. Paul’s and Vancouver General Hospital Sites.
In March 2003 the Chief Residents coordinated the “Resident Whistler Conference” which was held over a two-day period in Whistler. This event was a highly successful, well-attended and well-evaluated event which has replaced the past Whistler Ski Days that had not been held for the past three years. The success of this event was very much due to the hard work of the Chief Residents – Drs. Mark Lysyshyn, Julie Lee and Simon Yu.
May, once again, gave way to our highly acclaimed Resident Research Day. This year we were pleased to welcome adjudicators Dr. Peter Hamilton – Internal Medicine Program Director from the University of Alberta; Dr. Tom Wilson - Head, General Internal Medicine at the University of Saskatchewan and Dr. Hector Baillie – a General Internist from Nanaimo, BC. This year saw the development of two new major awards. The Chief Residents have implemented the “Shelley Naiman Award for Excellence in Clinical Teaching”. This award was presented to Dr. Shelley Naiman at St. Paul’s Hospital and Dr. Ken Gin of Vancouver General Hospital. This award will be presented each year to a clinical teacher at both sites and will be determined each year by the residents. As well, the Department of Medicine developed the first G.B.John Mancini Resident Research Achievement Prize – an annual prize which will be presented to the resident or fellow who has participated consistently and at a high level in the Resident Research Day through presentation of original research. Dr. Alnoor Ramji was the first recipient of this prize.
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Community Program Director, Dr. Steven Wong, worked with seven community training sites throughout BC--Nanaimo, Victoria, Kamloops, Prince George, Maple Ridge, North Vancouver and Richmond--to develop community rotations for the second and third year residents. These were successfully implemented beginning July 2003. Dr. Wong was also responsible for the development and implementation of the Palm Pilot Project – a tracking project which enables residents to track and evaluate procedures throughout their training period.
In July 2003, under the guidance of Dr. Vinay Dhingra, our PGY-1s were required, for the first time, to participate in a mandatory two day “Review of the Fundamental Critical Care Support Course (FCCS)”. The two day course is designed by the Society of Critical Care Medicine and was highly successful and beneficial course which was well-received and evaluated by the residents.
With the completion of 2003 the Department of Medicine has lead the way in the Faculty of Medicine with the final implementation in all areas of the new web-based WebEval System. This system has allowed for dual evaluation of both faculty/rotations and residents as well as maintaining a online program schedule. The Residency Training Program in the Department of Medicine has been active in working with One 45 Software in the continuing development of systems and will be working with them in 2004 to help in the development of an on-line automated scheduling program. This will be piloted for the 2004/2005 academic year.
New challenges for the year 2004 will include a curriculum review and the implementation of a new scheduling format using a 6-week rotation schedule. As well, the Postgraduate Training Programme will review CTU structure and function. We hope that the positive momentum from 2003 will continue in 2004.
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UNDERGRADUATE EDUCATION PROGRAM
Dr. H. Grant Stiver Professor and Director
In the 2002-03 semester, the Undergraduate Program continues to be actively involved in the bedside training of Second Year medical students prior to entering the Clinical Clerkship. In the Third Year Clerkship, the National Board of Medical Examiners (NBME) Shelf Examination in Medicine continues to be the written examination administered to Third Year clerks at the end of their eight-week Clinical Teaching Unit (CTU) rotation in Internal Medicine. We are also in the process of preparing pilot clerkship rotations in support of the Medical School Expansion.
Second Year Bedside Clinical Skills: In the 2002-03 academic year, the Second year bedside teaching sessions were again well received by both faculty and students. These sessions continue to be one of the highest rated courses in the undergraduate curriculum. We have continued with these sessions this current academic year where students are assigned a patient and perform a complete and focused history and physical examination, reviewed at the bedside by a clinician preceptor who also critiques the student’s write-up of the case. The duration of the course this academic year remains the same as last, January to May, 2004.
Third Year Clerkship
Written Examination at the End of the Third year Clerkship in Medicine: The National Board of Medical Examiners Shelf Examination in Medicine continues to be administered to all clinical clerks at the end of the 8-week Medicine clerkship. Advantages are the consistent quality of the clinical case scenarios requiring not only a knowledge base but also some clinical problem solving skills, as well as the opportunity to compare the performances of our students with students at a similar stage of training across North America and assess deficiencies and strengths of our curriculum. Our students are at or above the mean for North American 8-week clerkships on the NBME exams. The performance of UBC first-time examinees of the NBME shelf examination in Medicine (all clerkship rotations) during the 2002-03 academic year resulted in a mean subject exam test score of 73.5 which is equal to the mean for North American medical schools who have an 8 week clerkship (73.7). The performance of students beginning the clerkship at the end of Third Year generally increased compared with the performance of the students beginning in September, reflecting the increased clinical experience acquired throughout the year.
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Medical School Expansion: We are currently in the process of putting together proposals for pilot clerkships in preparation of the Medical School Expansion. Pilot clerkships include three models: a CTU model with resident and attending supervision, a community hospital rotation with an internist preceptor and with some medical resident interaction, and an “integrated” rotation in which students are preceptored by a family physician and encounter medicine problems through his or her patients and interactions with consulting internists and specialty clinics. The first increase of medical students entering the Third Year Clerkship is expected to be in the Year 2006.
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PUBLICATIONS
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Allergy & Immunology
Schellenberg, Dr Robert • Schellenberg RR. Abstracts from the 11th annual Canadian resident fellow competition in respiratory research. Can Respir J. 10(6): 336-343. 2003
Cardiology
Aymong, Dr Eve D • Ashby D, Dangas G, Aymong E, Farkouh M, Mehran R, Lansky A, Moses J, Leon M, Stone GW. Relation between the degree of procedural anticoagulation and complications after coronary stent implantation. American Journal of Cardiology. 2003; 92:319-22. • Shea S, Aymong E, Zybert P, Berglund L, Shamoon H, Deckelbaum R, Basch C. Fasting plasma insulin modulates lipid levels and particle sizes in 2- to 3-year-old children. Obes Res. 2003;11:709-21. • Ashby D, Mehran R, Aymong E, Lansky AJ, Iakovou I, Weisz G, Nw G, Moussa I, Dangas G, Moses JW, Stone GW, Leon MB. Comparison of outcomes in men versus women having percutaneous coronary interventions in small coronary arteries. American Journal of Cardiology, Apr 2003; 91(8):979-81. • Ashby D, Dangas G, Aymong E, Iakovou I, Kuepper F, Mehran R, Stone GW, Leon MB, Moses JW. Effect of percutaneous coronary interventions for in-stent restenosis in degenerated saphenous vein grafts without distal embolic protection. Journal of American College of Cardiology Mar 2003; 41(5):749-52. • Nikolsky E, Aymong E, Dangas G, Mehran R. Radiocontrast nephropathy: Identifying the high-risk patient and the implications of exacerbating renal function. Review of Cardiovascular Medicine 2003; 4Suppl1:27-S14. • Shea S, Aymong E, Zybert P, Berglund L, Shamoon H, Tracy R, Deckelbaum R, Basch C. The Relationship Between Measures of Obesity and Fasting Plasma Insulin in Healthy 2- to 3-Year Olds. Obesity Research Jan 2003; 11(1):95-103. • Mehran R, Aymong ED, Ashby D, Fischell T, Whithworth H, Siegel R, Thomas W, Wong CS, Narasimaiah R, Lansky A, Leon M. The safety of an aspirin alone regimen post intracoronary stenting with a heparin-coated stent: Final results of the HOPE (Hepacoat™ and an Antithrombotic Regimen of Aspirin Alone) Study. Circulation Sep 2003;108(9):1078-83. • Ashby DT, Aymong ED, Tcheng JE, Grines CL, Cox DA, Mehran R, Garcia E, Griffin JJ, Guagliumi G, Stuckey T, Turco M, Lansky AJ, Stone GW; CADILLAC Trial. Outcomes following bail-out abciximab administration during primary intervention in acute myocardial infarction (The CADILLAC Trial). American Journal of Cardiology Nov 2003;92(9):1091-4. • Ashby DT, Aymong ED, Grines CL, Cox DA, Garcia E, Mehran R, Tcheng JE, Griffin JJ, Guagliumi G, Stuckey T, Carroll JD, Turco M, Lansky AJ, Stone GW; CADILLAC trial. Outcomes of bail-out stenting for suboptimal balloon angioplasty during primary intervention in acute myocardial infarction (The CADILLAC trial). American Journal of Cardiology Nov 2003;92(9):1095-8. • Iakovou I, Dangas G, Mehran R, Mintz GS, Lansky AJ, Aymong ED, Nikolsky E, Vagaonescu T, Glasser LA, Stone GW, Leon MB, Moses JW. Comparison of effect of glycoprotein IIb/IIIa inhibitors during percutaneous coronary interventions on risk of hemorrhagic stroke in patients
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>or=75 years of age versus those <75 years of age. American Journal of Cardiology Nov 2003;92(9):1083-6. • Iakovou I, Mintz GS, Dangas G, Abizaid A, Mehran R, Kobayashi Y, Lansky AJ, Aymong ED, Nikolsky E, Stone GW, Moses JW, Leon MB. Increased CK-MB release is a "trade-off" for optimal stent implantation: an intravascular ultrasound study. J Am Coll Cardiol. Dec 2003;42(11):1900-5. Buller, Dr. Christopher E • Tcheng J, Madan M, O’Shea J, Cohen E, Buller CE, Lincoff AM, Popma JJ, Theirstein P, Kitt M, Lorenz T, Greenberg S, Fost N, Califf R. Ethics and Equipoise: Rationale for a Placebo-Controlled Study Design of Platelet Glycoprotein IIb/IIIa Inhibition in coronary Intervention. J Interven Cardio 2003;15:97-105. • Webb JG, Lowe AM, Sanborn TA, White HD, Sleeper LA, Carere RG, Buller CE, Wong SC, Boland J, Dzavik V, Porway M, Pate G, Bergman G, Hochman J. Percutaneous Coronary Intervention for Cardiogenic Shock In the SHOCK Trial. J Am Coll Cardiol 2003; 42(8): 1380-6. • Pate GE, Humphries KH, Izadnegahear M, Gao M, Kiely M, Buller CEH, Webb JG, SimkusG, Mildenberger R, Carere RG. Coronary angiography, angioplasty and bypass surgery in British Columbia, Canada. 1995-2001. Can J Cardiol 2003;19(A):172A Carere, Dr. Ronald G • Gordon E Pate, Karin Humphries Mona Izadnegahdar, Min Gao Michael Kiely, Ronald G Carere, Simkus G, Mildenberger R. Coronary angiography, angioplasty and bypass surgery in British Columbia, Canada. 1995-2001. Can J Cardiol 2003;19(A):172A • Pate GE; Webb JG; Carere RG. An unusual complication of coil embolization of a large coronary-pulmonary fistula. J Invasive Cardiol 2003 Dec;15(12): p717-8 • Webb JG; Lowe AM; Sanborn TA; White HD; Sleeper LA; Carere RG; Buller CE; Wong SC; Boland J; Dzavik V; Porway M; Pate G; Bergman G; Hochman JS. Percutaneous coronary intervention for cardiogenic shock in the SHOCK trial. J Am Coll Cardiol. 2003 Oct 15;42(8): p1380-6 • Webb JG, Pate A, Levin A, Humphries KH, Ricci D, Hamburger J, Alshehri A, Vaderah S, Williams T, Sutander A, Carere RG. Intravenous acetylcysteine in the prevention of contrast-induced nephropathy: A randomized trial. Can J Cardiol 2003;19(A):138A Chan, Dr. Sammy • Jasmine Grewal, Sammy Chan, Jiri Frohlich, G.B. John Mancini. Assessment of novel risk factors in patients at low risk for cardiovascular events based on Framingham risk stratification. Clinical and Investigative Medicine 2003 Aug; 26(4):158-65. • Birmingham CL, Lear SA, Kenyon J, Chan SY, Mancini GB, Frohlich J. Coronary atherosclerosis in anorexia nervosa. Int J Eat Disord. 2003; 34(3):375-7. • Sammy Y. Chan, G.B. John Mancini, Lisa Kuramoto, Michael Schulzer, Jiri Frohlich, Andrew Ignaszewski. The Prognostic Importance of Endothelial Dysfunction and Carotid Atheroma Burden in Patients with Coronary Artery Disease. Journal of the American College of Cardiology 2003 Sept 17; 42(6):1037-43. • Shanks M, Ignaszewski AP, Chan SY, Allard MF. Churg-Strauss syndrome with myocarditis manifesting as acute myocardial infarction with cardiogenic shock: case report and review of the literature. Can J Cardiol. 2003 Sep;19(10):1184-8.
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Dodek, Dr. Arthur • Mao CR, Liu G; Dodek A. Chronic CAD and Antiplatletes - What's the fit? Perspectives in Cardiology, Volume 19, No.8, September 2003. Fung, Dr. Anthony Y • Dixon KL, Coquinco B, Vandervoort EJ, Fung A, Celler A. Quantitation of myocardial perfusion defect size. Medical Physics 2003;30(7):1950-51. • Sunderji R, Fung A, Gin K, Shalansky K, Carter C. Patient self-management of oral anticoagulation: a review. Can J Cardiol. 2003;19:931-5.
Gin, Dr. Kenneth G • Picard MH, Davidoff R, Gin K et al. Echocardiographic Predictors of Survival and Response to Early Revascularization in Cardiogenic Shock, Circulation January 2003: 279-284. • Wood A, Gin KG. Vitamin Supplements -- Do They Help? Perspectives in Cardiology, September 2003: 57-61. • Leung V, Sunderji R, Zed P, Gin K. Switching from AbCIXMAB to Eptifbatide for Percutaneous Coronary Interventions: A Local Analysis (SWAP Study), The Can J. of Card, June 2003, Vol. 19 No. 7: 809-814. • R Sunderji, A Fung, K Gin, K Salansky, C Carter. Patient Self-Management of Oral Anticoagulation: A review. Can J. of Card, July 2003, Vol 19: No. 8: 931-93. • Dokainish H, Gin K, Lee PK, Jue J. Left Ventricular Filling Patterns and Pulmonary Artery Pressures in Patients Aged 90-100 Years with Normal Echocardiography Results, J. Am. Soc. of Echo 2003, Vol. 16, No. 6:664-9. Hamburger, Dr. Jaap N • Webb JG, Pate A, Levin A, Humphries KH, Ricci D, Hamburger J, Alshehri A, Vaderah S, Williams T, Sutander A, Carere RG. Intravenous acetylcysteine in the prevention of contrast-induced nephropathy: A randomized trial. Can J Cardiol 2003;19(A):138A Humphries, Dr. Karin • Shalansky SJ, Virk R, Ackman M, Jackevicius C, Kertland H, Tsuyuki R, Humphries KH. Access to new cardiovascular therapies in Canadian hospitals: A national survey of the formulary process. Can J Cardiol 2003; 19(2):1173-1179. • Braitstein P, Yip B, Heath KV, Levy A, Montaner JSG, Humphries K, Kielyc FM, O'Shaughnessy MV, Hogg RS. Interventional cardiovascular procedures among HIV-infected individuals on antiretroviral therapy 1995-2000. AIDS 2003; 17:2071-75. • Moss RR, Humphries KH, Gao M, Thompson CR, Abel JG, Fradet G, Munt BI. Outcome of mitral valve repair or replacement: a comparison by propensity score analysis. Circulation 2003 Sep 9;108(10 Suppl 1):II90-7. • LeLorier P, Humphries, KH, Krahn A, Connolly S, Talajic M, Green M, Sheldon R, Dorian P, Newman D, Kerr CR, Yee R, Klein GJ. The Canadian Registry of Atrial Fibrillation: Lack of prognostic differences between atrial fibrillation and atrial flutter. J Am Coll Cardiol 2003;41 (Suppl A): 102A • Hemmelgarn BR, Ghali WA, Southern D, Humphries KH, Knudtson ML. Association between level of kidney function and survival after cardiac catheterization. J Am Soc Nephrol 2003;14:676A.
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• Webb JG, Pate A, Levin A, Humphries KH, Ricci D, Hamburger J, Alshehri A, Vaderah S, Williams T, Sutander A, Carere RG. Intravenous Acetylcysteine in the Prevention of Contrast-Induced Nephropathy: A Randomized Trial. Can J Cardiol 2003;19(A):138A. • Pate GE, Humphries KH, Izadnegahdar M, Gao M, Kiely M, Buller CEH, Webb JG, Simkus G, Mildenberger R, Carere RG. Coronary angiography, angioplasty and bypass surgery in British Columbia, Canada, 1995-2001. Can J Cardiol 2003;19(A):172A. • Qi A, Kerr CR, Humphries KH, Sanatani S, Tung S, Uerojanaunjoltul P, Tyers GFO, Ueung-Lai-Wah JA. Long-term performance of implantable cardioverter defibrillator generators and high voltage leads post implant: frequency and causes of removal from service. Can J Cardiol 2003;19(A):216A. Circulation 2003;107:279-84. Ignaszewski, Dr. Andrew P • Bentkover JD, Stewart EJ, Ignaszewski A, Lepage S, Liu P, Cooper J. New technologies and potential cost savings related to morbidityand mortality reduction in Class III/IV heart failure patients in Canada. Int J Cardiol. 2003;88:22-41. • Cuff DJ, Meneilly GS, Martin A, Ignaszweski A, Tildesley HD, Frohlich JJ. Effective Exercise Modality to Reduce Insulin Resistance in Women with Type 2 Diabetes. Diabetes Care 2003; 26(11):2977-2982. • Kinnaird TD, Munt BI, Ignaszewski AP, Abel JG, Thompson RC. Edge-to-edge repair for functional mitral regurgitation: an echocardiographic study of the hemodynamic consequences. J Heart Valve Dis. 2003; 12:280-6. • Chan SY, Mancini GBJ, Kuramoto L, Schulzer M, Frohlich J, Ignawzewski A. The prognostic importance of endothelial dysfunction and carotid athermaburden in patients with coronary artery disease. Journal of the American College of Cardiology 2003; 42(6):1037-1043. • Lear SA, Ignaszewski A, Linden W, Brozic A, Kiess M, Spinelli JJ, Pritchard PH, Frohlich JJ. The Extensive Lifestyle Management Intervention (ELMI) following cardiac rehabilitation trial. European Heart Journal 2003; 24:1920-1927. • Shanks M, Ignaszewski AP, Chan SY, Allard MF. Churg-Strauss syndrome with myocarditis manifesting as acute myocardial infarction with cardiogenic shock: case report and review of the literature. Can J Cardiol. 2003; 19:1184-8. • Wood D, Chandavimol, Ignaszewski AP. Tried and true hypertension guideline. Can J CME 2003;15(3). Jue, Dr. John • Dokainish H, Gin K, Lee PK, Jue J. Left ventricular filling patterns and pulmonary artery pressures in patients aged 90 to 100 years with normal echocardiography results. J Am Soc Echocardiogr. 2003;16:664-9. Kerr, Dr. Charles R • Gillis AM, Philippon F, Cassidy MR, Singh N, Dorian P, Love BA, Kerr CR. Guidelines for implantable cardioverter defibrillator follow-up in Canada: a consensus statement of the Canadian Working Group on Cardiac Pacing. Can J Cardiol. 2003;19:21-37. • Lelorier P, Humphries KH, Krahn A, Connolly SJ, Talajic M, Green M, Sheldon R, Dorian P, Newman D, Kerr CR, Yee R, Klein GJ. The Canadian Registry of Atrial Fibrillation: Lack of Prognostic differences between atrial fibrillation and atrial flutter. Am J Cardiol. 2003;41(Suppl A):102A
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• Newman D, Lau C, Tang AS, Irvine J, Paquette M, Woodend K, Dorian P, Gent M, Kerr C, Connolly SJ. Effect of pacing mode on health-related quality of life in the Canadian Trial of Physiologic Pacing. Am Heart J. 2003;145:430-7. • Qi A, Kerr CR, Humphries KH, Sanatani S, Tung S, Uerojanaunjoltul P, Tyers GFO, Ueung-Lai-Wah JA. Long-term performance of implantable cardioverter defibrillator generators and high voltage leads post implant: frequency and causes of removal from service. Can J Cardiol 2003:19(A):216A Circulation. 2003;107:279-84.
Kiess, Dr. Marla • Mieres JH, Shaw LJ, Hendel RC, Miller DD, Bonow RO, Berman DS, Bairey-Merz CN, Cacciabaudo JM, Heller GV, Kiess MC, Polk DM, Shaw LJ, Smanio PE, Walsh MN. A report of the American Society of Nuclear Cardiology Task Force on Women and Heart Disease (Writing Group on Perfusion Imaging in Women) J Nucl Cardiol. 2003 Jan-Feb; 10(1):95-101, 2003. • Lear SA, Ignaszewski A, Linden W, Brozic A, Kiess MC, Spinelli, JJ, Haydn Pritchard P, Frohlich JJ. The Extensive Lifestyle Management Intervention (ELMI) following cardiac rehabilitation trial. Eur Heart J. 24(21): 1920-7, 2003. • Mackay, M., Fofonoff, D., Kiess, M. Hearts at risk: Processes for co-managing the obstetric patient with cardiac disease. Canadian Journal of Cardiovascular Nursing 13(4):28, 2003. Mancini, Dr. G B John • Birmingham CL, Lear SA, Kenyon J, Chan SY, Mancini GBJ, Frohlich J. Coronary atherosclerosis in anorexia nervosa. Int J Eat Disord. Nov. 2003; 34(3):375-7. • Langer A, Constance C, Fodor JG, Frohlich JJ, Gregoire J, Lau DCW, Leiter LA, Mancini GBJ, Marr D, McPherson R, O'Neill BJ, Rabkin S. Statin therapy and the management of acute coronary syndromes. Can J Cardiol 2003; 19(8): 921-927 • Grewel J, Chan S, Frohlich J, Mancini GBJ. Assessment of novel risk factors in patients at low risk for cardiovascular events based on Framingham risk stratification. Clin Invest Med 2003; 26(4):158-165. • Chan S, Mancini GBJ, Kuramoto L, Schulzer M, Frohlich J, Ignaszewski A. The Prognostic Importance of Endothelial Dysfunction and Carotid Atheroma Burden in Patients With Coronary Artery Disease. JACC 2003; 42(6): 1037-1043 Munt, Dr. Bradley I • Kinnaird TD, Munt BI, Ignaszewski AP, Abel JG, Thompson RC. Edge-to-edge repair for functional mitral regurgitation: an echocardiographic study of the hemodynamic consequences. J Heart Valve Dis. 2003;12:280-6. • Moss RR, Humphries KH, Gao M, Thompson CR, Abel JG, Fradet G, Munt BI. Outcome of mitral valve repair or replacement: a comparison by propensity score analysis. Circulation. 2003;108 Suppl 1:II90-7. • Moss R, Munt B, Injection drug use and right sided endocarditis. Heart. 2003 May;89(5):577-81 Rabkin, Dr. Simon W • Langer A, Constance C, Fodor JG, Frohlich JJ, Gregoire J, Lau DCW, Leiter LA, Mancini GBJ, Marr D, McPherson R, O’Neill B, Rabkin SW. Statin therapy and the management of acute coronary syndromes; Can J Cardiol 2003;19(8):921-927 Ricci, Dr. Donald R
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• Webb JG, Pate A, Levin A, Humphries KH, Ricci D, Hamburger J, Alshehri A, Vaderah S, Williams T, Sutander A, Carere RG. Intravenous acetylcysteine in the prevention of contrast-induced nephropathy: A randomized trial. Can J Cardiol 2003;19(A):138A Thompson, Dr. Christopher R • Kinnaird TD, Munt BI, Ignaszewski AP, Abel JG, Thompson RC. Edge-to-edge repair for functional mitral regurgitation: an echocardiographic study of the hemodynamic consequences. J Heart Valve Dis. 2003;12:280-6. • Moss RR, Humphries KH, Gao M, Thompson CR, Abel JG, Fradet G, Munt BI. Outcome of mitral valve repair or replacement: a comparison by propensity score analysis. Circulation. 2003;108 Suppl 1:II90-7. • Picard MH, Davidoff R, Sleeper LA, Mendes LA, Thompson CR, Dzavik V, Steingart R, Gin K, White HD, Hochman JS. Echocardiographic predictors of survival and response to early revascularization in cardiogenic shock. Circulation January 2003: 279-284. Tung, Dr. Kei Kwong (Stanley) • Qi A, Kerr CR, Humphries KH, Sanatani S, Tung S, Uerojanaunjoltul P, Tyers GFO, Ueung-Lai-Wah JA. Long-term performance of implantable cardioverter defibrillator generators and high voltage leads post implant: frequency and causes of removal from service. Can J Cardiol 2003:19(A):216A Circulation. 2003;107:279-84. • Tung S, Soejima K, Maisel WH, Suzuki M, Epstein L, Stevenson WG. Recognition of far-field electrograms during entrainment mapping of ventricular tachycardia. J Am Coll Cardiol. 2003 Jul 2;42(1):110-5.
Webb, Dr. John G • Pate GE, Humphries KH, Izadnegahear M, Gao M, Kiely M, Buller CEH, Webb JG, SimkusG, Mildenberger R, Carere RG. Coronary angiography, angioplasty and bypass surgery in British Columbia, Canada. 1995-2001. Can J Cardiol 2003;19(A):172A • Pate GE, Webb JG, Carere RG. An unusual complication of coil embolization of a large coronary-pulmonary fistula. J Invasive Cardiol. 2003;15:717-8. • Sanborn TA, Sleeper LA, Webb JG, French JK, Bergman G, Parikh M, Wong SC, Boland J, Pfisterer M, Slater JN, Sharma S, Hochman JS. Correlates of one-year survival inpatients with cardiogenic shock complicating acute myocardial infarction: angiographic findings from the SHOCK trial. J Am Coll Cardiol. 2003;42:1373-9. • Vanderah S, Webb J. Long-term warfarin and percutaneous intervention. J Invasive Cardiol. 2003;15:63-4. • Webb JG, Pate A, Levin A, Humphries KH, Ricci D, Hamburger J, Alshehri A, Vaderah S, Williams T, Sutander A, Carere RG. Intravenous acetylcysteine in the prevention of contrast-induced nephropathy: A randomized trial. Can J Cardiol 2003;19(A):138A
Critical Care
Dhingra, Dr. Vinay K • Gorman S, Dhingra VK, Zed P, Ronco JJ. Rapid Imipenem-Cilastin Desensitization for multi-drug resistant Acinetobacter Pneumonia. Annals of Pharmacotherapy, 2003;37:513-16
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• Henderson WB, Dhingra VK, Chittock DR, Fenwick JC, Ronco JJ. Lack of Utility of Hypothermia in the Management of Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Intensive Care Medicine 2003. Dodek, Dr. Peter M • Dodek P and Raboud J. Introduction of an explicit process for bedside rounds in an Intensive Care Unit improves communications and satisfaction of health care providers. Intensive Care Medicine 29: 15834-1588, 2003. • Heyland DK, Cook DJ, Rocker GM, Dodek PM, Kutsogiannis DJ, Peters S, Tranmer JE, O'Callaghan CJ. Decision making in the ICU: Perspectives of the substitute decision maker. Intensive Care Medicine. 29:75-82, 2003. • Heyland DK, Rocker GM, O'Callaghan CJ, Dodek PM, Cook DJ. Dying in the Intensive Care Unit: Perspectives of Family Members. Chest, 124:392 - 397, 2003. • Keenan SP, Dodek PM, Chan K, Hogg RS, Craib KJP, Anis AH, Spinelli JJ. Length of ICU stay for chronic obstructive lung disease varies among large community hospitals. Intensive Care Medicine, 29:590-595, 2003. • Heyland DK, Dhaliwal R, Drover JW, Gramlich L, Dodek P and the Canadian Critical Care Clinical Practice Guidelines Committee. Canadian Clinical Practice Guidelines for Nutrition Support in Mechanically Ventilated, Critically Ill Adult Patients. J Parenter Enteral Nutr 27: 355-373, 2003. • Cook D, Rocker G, Marshall J, Sjokvist P, Dodek P, Griffith L, Freitag A, Varon J, Bradley C, Levy M, Finfer S, Hamielec C, McMullin J, Weaver B, Walter S, Guyatt G for the Level of Care Study Investigators & the Canadian Critical Care Trials Group. Withdrawal of mechanical ventilation in anticipation of death in the intensive care unit. N Engl J Med. 349:1123-1132, 2003. • Dodek P. Mandatory Reporting of "Imminent" Death to Identify Organ Donors: History, Controversy, and Potential Solutions. Can J Anesthesia 50: 955-960, 2003. Dorscheid, Dr. Delbert R • Dorscheid DR, Low E, Conforti A, Shifrin S, Sperlin AI, White SR. Corticosteroid-induced apoptosis in mouse airway epithelium: effect in normal airways and after allergen-induced airway inflammation. JACI 2003; 111: 360-366. • Robert Tse, Bertyha A Marroquin, Delbert R Dorscheid, and Steven R White. Beta-adrenergic agonists reverse corticosteroid-induced apoptosis of airway epithelial cells. Am J Physiol (Lung Cell Molec Physiol) 285: L393-L404, 2003. • Ehsan Y Davani MD, MSc, Zabrina Brumme BSc, Gurpreet K Singhera PhD, Hélène C. F. Côté, P Richard Harrigan PhD, and Delbert R Dorscheid MD, PhD. IGF-1 protection of ischemic murine myocardium from ischemia-reperfusion associated injury. Critical Care 7:R176-R183, 2003. • Danyi Zhou, Xueyan Zheng, Lu Wang, Gerald Stelmack, Andrew J. Halayko, Delbert Dorscheid, and Tony R. Bai. Expression and Effects of Cardiotrophin-1 (CT-1) in Human Airway Smooth Muscle Cells. Br J Pharmacol 140:1237-44. Epub Nov 03, 2003. Keenan, Dr. Sean P • Keenan SP, Mawdsley C, Plotkin D, Kossuth J, Sibbald WJ, for the Critical Care Research Network. Inter-hospital variability in withdrawal of life support: room for improvement? Crit Care Med 2003 Feb;31(2):626-31
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• Keenan SP, Hogg R, Chan K, Craib K, Anis A, Spinelli J, Dodek P. Length of ICU and hospital stay for Chronic Obstructive Pulmonary Disease (COPD) varies among large community hospitals. Intensive Care Med, 2003 March 15 • Keenan SP, Sinuff T, Cook DJ, Hill NS. When is the addition of noninvasive positive pressure ventilation effective in acute exacerbations of COPD? A systemic review of the literature. Ann Intern Med. 2003 Jun 3;138(11):861-70 • Angus DC, Carlet J, on behalf of the 2002 Brussels Roundtable Participants. Surviving intensive care: A report from the 2002 Brussels Roundtable. Intensive Care Med 2003 Apr;29(4):590- 5. Ronco, Dr. Juan J • Gorman S, Dhingra V, Zed P, Ronco JJ. Rapid Imipenem-Cilastatin desensitization for multi-drug resistant Acinetobacter pneumonia. Annals of Pharmacotherapy 2003; 37: 513-516. • Henderson WR, Dhingra VK, Chittock DR, Fenwick JC, Ronco JJ. Lack of utility of hypothermia in the management of traumatic brain injury: A systemic review and meta-analysis. Intensive Care Medicine 2003; 29:1637-1644. • Chittock DR, Henderson W, Dhingra V, Ronco JJ. Glycemic control in the critically ill; how sweet it is. Critical Care Rounds 2003, 4(6). Russell, Dr. James A • Garber G, Cunningham K, Gibney RTN, Guimond JG, Light B, Magder S, Martin C, Russell JA, Stewart T. Guidance on patient identification and administration of recombinant activated protein C (rhAPC) for the treatment of severe sepsis. Can J Inf Dis 2002; 13(6):361-372. • Holmes CL, Russell JA, Walley KR. Genetic polymorphisms in sepsis and septic shock: Role in prognosis and potential for therapy. Chest 2003; 124: 1103-1115. • Walley KR, McDonald TE, Wang Y, Dai S, Russell JA. Albumin resuscitation increases cardiomyocyte contractility and decreases nitric oxide synthase II expression in rat endotoxemia. Crit Care Med 2003; 31: 187-194. • Russell JA. Genetics of coagulation factors in acute lung injury. Crit Care Med 2003; 31(4): 243-247. • Dhaineault JF, Russell JA, Brower R. Acute lung injury. Crit Care Med 2003; 31(4): 183. • Zavorsky G, Walley KR, Russell JA. Red cell pulmonary transit times through the healthy human lung. Exp Physiol 2003; 88:191-200. • Zavorsky G, Walley KR, Russell JA. Acute hypervolemia improves arterial oxygen pressure in athletes with exercise-induced hypoxemia. Experimental Physiology 2003; 88.4: 555 - 564. • Manocha S, Walley KR, Russell JA. Severe Acute Respiratory Distress Syndrome (SARS): A Critical Care Perspective. Crit Care Med 2003; 31:2684-92. • Dhainault JF, Yan SB, Margolis BD, Lorente JA, Freebairn RC, Russell JA et al. Drotrecogin alfa (activated) reduces host coagulopathy response in patients with severe sepsis. Thrombosis & Hemostasis 2003; 90: 642 - 653. • Russell JA. Vasopressin in septic shock: Clinical equipoise means a time for restraint. Crit Care Med 2003;31:2707-2709. Tsang, Dr. John Y • Simon M, Battistini B, Yong JK, Tsang JY. Plasma levels of endothelin-1, big endothelin-1 and thromboxane following acute pulmonary air embolism. Respir Physiol & Neurobiol 2003;
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138:97-106. Walley, Dr. Keith R • Walley KR, McDonald TE, Wang Y, Dai S, Russell JA. Albumin resuscitation increases cardiomyocyte contractility and decreases NOS II expression in rat endotoxemia. Crit Care Med. 2003; 31: 187-194. • Zavorsky GS, Walley KR, Russell JA. Red cell pulmonary transit times through the healthy human lung. Exp Physiol 88(Pt 2):1991-200, 2003. • Holmes CL, Walley KR. Bad medicine: Low-dose dopamine in the ICU. Chest. 123(4):1266-75, 2003. • Loucks EB, Godin DV, Walley KR, McManus BM, Rahimian R, Granville DJ, Hong JM, Aktary FM, Qayumi AK. Role of platelet activating factor in cardiac dysfunction, apoptosis and nitric oxide synthase mRNA expression in the ischemic-reperfused rabbit heart. Can J Cardiol. 19(3):267-274, 2003. • Zavorsky GS, Walley KR, Hunte GS, McKenzie DC, Sexsmith GP, Russell JA. Acute hypervolemia improves arterial oxygen pressure in athletes with exercise-induced hypoxemia. Exp Physiol. 88(4):555-564, 2003. • Bosan S, Kareco T, Ruehlmann D, Chen KY, Walley KR. Three-dimensional capillary geometry in gut tissue. Microsc Res Tech. 1;61(5):428-437, 2003. • Holmes CL, Russell JA, Walley KR. Genetic polymorphisms in sepsis and septic shock: Role in prognosis and potential for therapy. Chest. 124(3):1103-1115, 2003. • Manocha S, Walley KR, Russell JA. Severe Acute Respiratory Distress Syndrome (SARS): A Critical Care Perspective. Crit Care Med. 31(11):2684-2692, 2003.
Dermatology
Au, Dr. Sheila • Prendiville J, Cabral D, Poskitt K, Au S, Sargent M. Central nervous system involvement in neonatal lupus erythematosus. Pediatric Dermatology 2003; 20(1):60-67. Dutz, Dr. Jan P • Trudeau JD, Kelly-Smith C, Verchere CB, Elliott JF, DUTZ JP, Finegood DT, Santamaria P, Tan R. Prediction of spontaneous autoimmune diabetes by quantification of autoreactive Tcells in peripheral blood. J Clin Invest 2003; 111:217-223. Haber, Dr. Richard M • Siegel DH, Haber RM et al. Loss of Kindlin-1, a Human Homolog of the Caenorhabditis elegans Actin-Extracellular-Matrix Linker Protein UNC-112, Causes Kindler Syndrome. Am J Hum Genet 2003; 73:174-187. Ho, Dr. Vincent • Paul CF, Ho VC, McGeown C, Christophers E, Schmidtmann B, Guillaume JC, Lamarque V, Dubertret L. Risk of malignancies in psoriasis patients treated with cyclosporine: A 5 year cohort study. J Invest Dermatol 2003; 120:211-216. • Su M, Dorocicz I, Wieslawa HG, Ho V, Li G, Voss N, Gascoyne R, Zhou Y. Aberrant
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expression of T-plastin in Sezary cells. Cancer Research 2003; 63:7122-7127.
Li, Dr. Gang • Luu Y, Li G. The p53-stabilizing compound CP-31398 does not enhance melanoma chemosensitivity. Anticancer Res. 2003; 23: 99-106. • Chen B, Campos El, Crawford R, Martinka M, Li G. Analyses of the tumor suppressor ING1 expression and gene mutation in human basal cell carcinomas. Int. J. Oncol. 2003; 22: 927-931. • Su M, Dorocicz I, Wieslawa HG, Ho V, Li G, Voss N, Gascoyne R, Zhou Y. Aberrant expression of T-plastin in Sezary cells. Cancer Research 2003; 63:7122-7127. • Dai D, Makretsov N, Campos EI, Huang C, Zhou Y, Huntsman D, Martinka M, Li, G. Increased expression of integrin-linked kinase is correlated with melanoma progression. Clin Cancer Res 2003; 9: 4409-4414. • Chin MY, Li G. Tissue-specific regulation of Chk2 expression by p53. Exp Mol Pathol 2003; 75: 131-136. Lui, Dr. Harvey • Lau DP, Huang Z, LUI H, Man CS, Berean K, Morrison MD, Zeng H. Raman spectroscopy for optical diagnosis in normal and cancerous tissue of the nasopharynx - preliminary findings. Lasers Med Surg 2003; 32:210-214. • Bernardo O, Tang L, LUI H, Shapiro J. Topical nitrogen mustard in the treatment of alopecia areata: A bilateral comparison study. J Am Acad Dermatol 2003; 291-294. • Shum DT, LUI H, Martinka M, Bernardo O, Shapiro J. Computerized morphometry and three-dimensional image reconstruction in the evaluation of scalp biopsy from patients with non-cicatricial alopecias. Brit J Dermatol 2003; 148:1-7. • Tang L, Bernardo O, Bolduc C, LUI H. Shapiro J. The expression of insulin-like growth factor I in follicular dermal papillae correlates with therapeutic efficacy of finasteride in adrogenetic alopecia. J Am Acad Dermatol 2003; 229-233. • Tang L, Cao L, Bernardo O, Chen Y, Sundberg, JP, LUI H, Chung S, Shapiro J. Topical mechlorethamine restores autoimmune-arrested follicular activity in mice with alopecia areata-like disease by targeting infiltrated lymphocytes. J Invest Dermatol 2003; 120: 400-406. • Huang Z, McWilliams A, Lam S, McLean DI, LUI H, Zeng H. Near-infrared Raman spectroscopy for optical diagnosis of lung cancer. Int J Cancer; 2003;107:1047-52. • Huang Z, McWilliams A, Lam S, English J, McLean DI, LUI H, Zeng H. Effects of formalin fixation on the near-infrared Raman spectroscopy of human bronchial tissues. Int J Oncol 2003;23:649-655. • Tang L, Cao K. Pelech S, LUI H, Shapiro J. Cytokines and signal transduction pathways mediated by anthralin in alopecia areata-affected Dundee experimental balding rats. J Invest Dermatol Symp Proc 2003;8:87-90. • Tang L, LUI H, Sundberg J, Shapiro J. Old wine in new bottles: Reviving old therapies for alopecia areata using rodent models. J Invest Dermatol Proceedings. 2003; 8:212-6. • LUI H, Shapiro J. Once daily application of calcipotriol and betamethasone dipropionate for the treatment of psoriasis. Skin Therapy Letter 2003;8(Suppl 1):1-2. • LUI H, Hobbs L, Tope W, Lee PK, Elmets C, Provost N, Chan A, Neyndorff H, Su XY, Jain H, Hamzavi I, McLean DI, Bissonnette R. Photodynamic therapy of multiple nonmelanoma skin
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cancers with verteporfin and LED light - two-year results evaluating tumor response and cosmetic outcomes. Arch Dermatol 2003; 140:26-32. • Tang, LUI H, Sundberg JP, Bissonnette R, McLean DI, Shapiro J. Restoration of hair growth with topical diphencyprone in murine and rate models of alopecia areata. J Am Acad Dermatol 2003; 49:1013-1019. McElwee, Dr. Kevin J • McElwee KJ, Niiyama S, Freyschmidt-Paul P,Wenzel E, Kissling S, Sundberg JP, Hoffmann R. Dietary soy oil and soy derived genistein increase resistance to alopecia areata onset in C3H/HeJ mice. Exp Dermatol 2003; 12:30-36. • Sundberg JP, Boggess D, Silva K, McElwee KJ, King LE, Renhua L, Churchill G, Cox G. Major locus on mouse chromosome 17 and minor locus on chromosome 9 are linked with alopecia areata in C3H/HeJ mice. J Invest Dermatol 2003; 120:771-775. • McElwee KJ, Freyschmidt-Paul P, Sundberg JP, Hoffmann R. The pathogenesis of alopecia areata in rodent models. J Invest Derma Symp Proc 2003; 8:6-11. • Freyschnmidt-Paul P, Happle R, McElwee KJ, Hoffmann R. Alopecia areata: Treatment of today and tomorrow. J Invest Derm Symp Proc 2003; 8:12-17. • Freyschmidt-Paul P, McElwee KJ, Botchkarev V, Kissling S, Wenzel E, Sundberg JP, Happle R, Hoffmann R. Fas deficient C3.MRL-Tnfrsf6lpr mice are not susceptible to alopecia areata after grafting of alopecia areata-affected skin from C3H/HeJ mice. J Invest Derm Symp Proc 2003; 89:104-108. Rivers, Dr. Jason K • MacLennan R, Harrison SL, Kelly JW, Rivers JK. The Eastern-Australian childhood nevus study: site differences in density and size of melanocytic nevi in relation to latitude and phenotype. J Am Acad Dermatol 2003;48(3):367-75. • Weichert G, Martinka M, Rivers JK. Intravascular lymphoma presetning as telangectasias: response to rituximab and ombination chemotherapy. J cutan Med Surg 2003;7:460-463. Shapiro, Dr. Jerry • Bernardo O, Tang L, Lui H, Shapiro J. Topical nitrogen mustard in the treatment of alopecia areata. J Am Acad Dermatology. 2003; 291-294. • Tang L, Bernardo O, Bolduc C, Madani S, Lui H, Shapiro J. The expression of insulin-like growth factor in follicular dermal papillae correlates the therapeutic efficacy of Finasteride in androgenetic alopecia. J Am Dermatol 2003; 229-233. • Shapiro J. Safety of topical minoxidil solution. J of Cutan Med Surg. Published online 28 July 2003. • Shapiro J, Kaufman KD. Use of finasteride in the treatment of men with androgenitic alopecia (male pattern hair loss). J Invest Dermatol Symp Proc 2003; 8:20-23. • Shum DT, Lui H, Martinka M, Bernardo O, Shapiro J. Computerized morphometry and three-dimensional image reconstruction in the evaluation of scalp biopsy from patients with non-cicatricial alopecias. Brit J Dermatol 2003; 148:1-7. • Tang L, Cao L, Pelech S, Lui H, Shapiro J. Cytokines and signal transduction pathways mediated by anthralin in alopecia areata-affected DEBR rats. J Invest Dermatol Symp Proc 2003; 8:87-90. • Tang L, Cao L, Bernardo O, Chen Y, Sundberg, JP, Lui H, Chung S, Shapiro J. Topical
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mechlorethamine restores autoimmune-arrested follicular activity in mice with alopecia areata-like disease by targeting infiltrated lymphocytes. J Invest Dermatol 2003; 120: 400-406. • Tang L, Cao K. Pelech S, Lui H, Shapiro J. Cytokines and signal transduction pathways mediated by anthralin in alopecia areata-affected Dundee experimental balding rats. J Invest Dermatol Symp Proc 2003;8:87-90. Shokravi, Dr. Mohammad • Alsadhan A, Taher M, Shokravi M. Cutaneous lymphadenoma. J Am Acad Dermatol. 2003;49(6):1115-6. Zhou, Dr. Youwen • Su MW, Dorocicz I, Degawska V, Voss N, Ho V, Li G, Gascoyne R, Zhou Y. Aberrant expression of T-plastin gene in Sezary cells. Cancer Research 2003; 63:7122-7127. • Dai DL, Makretsov N, Campos EI, Huang C, Zhou Y, Huntsman D, Martinka M, Li G. Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival. Clin Cancer Res 2003; 9(12):4409-4414. • Su MW, Dorocicz I, Degawska V, Voss N, Ho V, Li G, Gascoyne R and Zhou Y. Aberrant Expression of T-plastin gene in Sezary Cells (2003) Cancer Research 63:7122-7127
Endocrinology
Gill, Dr. Sabrina • Humphries K, Gill S. Hormone replacement therapy: The evidence speaks. Canadian Medical Association Journal 2003;168(8):1001-10 Kendler, Dr. David L • Drake WM, Kendler DL, Rosen CJ, Orwoll ES. An investigation of the predictors of bone mineral density and response to therapy with alendronate in osteoporotic men. J Clin Endocrinol Metab. 2003 Dec; 88(12): 5759-65.
Gastroenterology
Byrne, Dr. Michael F • MF Byrne, J Baillie. The use of propofol during endoscopy. Gastroenterology 2003; 124 (4): 1162-1163. • J Baillie, MF Byrne. ERCP- preparation, position, and instrumentation. Techniques in Gastrointestinal Endoscopy 2003; 5(1): 3-10. • MF Byrne, P Jowell. ERCP-methods of tissue sampling. Techniques in Gastrointestinal Endoscopy 2003; 5(1): 27-34. • MF Byrne, RM Mitchell, J Baillie. Management of ingested foreign bodies. Emergency Medicine 2003; 35(5): 55-58. • Bohra S, Byrne MF, Manning D, Smyth C, Patchett SE, Murray FE. A prospective analysis of inpatient consultations to a gastroenterology service. Ir Med J. 2003 Oct;96(9):263-5. • Byrne MF. Primary screening with colonoscopy for colorectal cancer: a targeted algorithm? Am
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J Gastroenterol. 2003 Dec;98(12):2587-9. • Byrne MF, Murphy JF, Corcoran PA, Atherton JC, Sheehan KM, Cox D, Murray FE, Fitzgerald DJ. Helicobacter pylori induces cyclooxygenase-1 and cyclooxygenase-2 expression in vascular endothelial cells. Scand J Gastroenterol. 2003 Oct;38(10):1023-30. • Gerke H, Byrne MF, Jowell PS. Unusual finding in a patient with pancreas divisum and abdominal pain. MedGenMed. 2003 Jul 30;5(3):14. • Byrne MF, Royston D, Patchett SE. Association of common variable immunodeficiency with atypical collagenous colitis. Eur J Gastroenterol Hepatol. 2003 Sep;15(9):1051-3. • Byrne MF, Suhocki P, Mitchell RM, Pappas TN, Stiffler HL, Jowell PS, Branch MS, Baillie J. Percutaneous cholecystostomy in patients with acute cholecystitis: experience of 45 patients at a US referral center. J Am Coll Surg. 2003 Aug;197(2):206-11. • Mitchell RM, Byrne MF. Biliary emergencies: pancreatitis, cholangitis, and more. Semin Gastrointest Dis. 2003 Apr;14(2):77-86. • Byrne MF, Baillie J. Predicting the likelihood of therapeutic ERCP. A suggested 'model' to limit the number of purely diagnostic ERCPs. Dig Liver Dis. 2003 Jul;35(7):458-60. • Byrne MF, Kerrigan SW, Corcoran PA, Atherton JC, Murray FE, Fitzgerald DJ, Cox DM. Helicobacter pylori binds von Willebrand factor and interacts with GPIb to induce platelet aggregation. Gastroenterology. 2003 Jun;124(7):1846-54. • Mitchell RM, Byrne MF, Baillie J. Colonoscopy or barium enema for population colorectal cancer screening? Dig Liver Dis. 2003 Apr;35(4):207-11. • Mitchell RM, Byrne MF, Baillie J. Pancreatitis. Lancet. 2003 Apr 26;361(9367):1447-55. • Byrne MF, Chong HI, O'Donovan D, Sheehan KM, Leader MB, Kay E, McCormick PA, Broe P, Murray FE, McCormack A. Idiopathic cholangiopathy in a biliary cast syndrome necessitating liver transplantation following head trauma. Eur J Gastroenterol Hepatol. 2003 Apr; 15(4):415-7. • Sheehan KM, O'Donovan DG, Fitzmaurice G, O'Grady A, O'Donoghue DP, Sheahan K, Byrne MF, Conroy RM, Kay EW, Murray FE. Prognostic relevance of Fas (APO-1/CD95) ligand in human colorectal cancer. Eur J Gastroenterol Hepatol. 2003 Apr;15(4):375-80. • Byrne MF, McVey G, Royston D, Patchett SE. Association of Clostridium difficile infection with collagenous colitis. J Clin Gastroenterol. 2003 Mar;36(3):285. • Shah AA, Byrne MF, Cullen L, Walsh T, Fitzgerald DJ, Murray FE. Effect of H. pylori infection on the expression of cyclooxygenase-2 in human gastric mucosa. Prostaglandins Leukot Essent Fatty Acids. 2003 Jan;68(1):1-8. Enns, Dr. Robert A • Enns R. AIDS cholangiopathy: "an endangered disease". Am J Gastroenterol. 2003 Oct;98(10):2111-2. • Gagnon YM, Levy AR, Eloubeidi MA, Arguedas MR, Rioux KP, Enns R. Cost implications of administering intravenous proton pump inhibitors to all patients presenting to the emergency department with peptic ulcer bleeding. Value Health. 2003 Jul-Aug;6(4):457-65. • Gan I, May G, Raboud J, Tilley J, Enns R. Pancreatitis in HIV infection: predictors of severity. Am J Gastroenterol. 2003 Jun;98(6):1278-83. • Andrews CN, Raboud J, Kassen BO, Enns R. Clostridium difficile-associated diarrhea: predictors of severity in patients presenting to the emergency department. Can J Gastroenterol. 2003 Jun;17(6):369-73.
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• Enns R, Eloubeidi MA, Mergener K, Jowell PS, Branch MS, Baillie J. Predictors of successful clinical and laboratory outcomes in patients with primary sclerosing cholangitis undergoing endoscopic retrograde cholangiopancreatography. Can J Gastroenterol. 2003 Apr;17(4):243-8. • Enns R, Gagnon YM, Rioux KP, Levy AR. Cost-effectiveness in Canada of intravenous proton pump inhibitors for all patients presenting with acute upper gastrointestinal bleeding. Aliment Pharmacol Ther. 2003 Jan;17(2):225-33. • R Enns. Acute Pancreatitis: The latest tactics for better care. Jan 2003, 11(1):110-3. • Enns R. What can the GP do? A bleeding ulcer. Can J CME, Mar 2003,15(3): 61-8. • A Barkun, M Bardow, J Marshall and the Concensus conference group. Concensus recommendations for managing patients with upper gastrointestinal bleeding. Annals of Internal Medicine 2003; 130:843-57. • R Enns. The bleeding bowel: A primary care approach. Patient Care 2003;14(3):40-47. • Barkun A, Armstrong D, Enns R, Fedorak R and Gregor J. Canadian Perspectives from Domestic and International Meetings. Early Results from RUGBE. Medical Resource Communications 2003;1-4. Erb, Dr. Siegfried R • Greig P, Lilly L, Scudamore C, Erb S, Yoshida E, Kneteman N, Bain V, Ghent C, Marotta P, Grant D, Wall W, Tchervenkov J, Barkun J, Roy A, Marleau D, McAlister V, Peltekian K. Early steroid withdrawal after liver transplantation: the Canadian tacrolimus versus microemulsion cyclosporin A trial: 1-year follow-up. Liver Transpl. 2003 Jun;9(6):587-95. Fishman, Dr. Martin J • Barkun A, Bardou M, Marshall JK, et al. Consensus recommendations for managing patients with nonvariceal upper gastrointestinal bleeding. Ann Int Med 2003; 139:843-57. Freeman, Dr. Hugh J • Freeman HJ, Hershfield NB. Anticipation in familial Crohn's disease. Pediatric Rev J 2003 • Freeman HJ. Temporal and geographic evolution of longstanding Crohn's disease over more than 50 years. Can J Gastroenterol. 2003 Dec;17(12):696-700. • Freeman HJ. Free perforation due to intestinal lymphoma in biopsy-defined or suspected celiac disease. J Clin Gastroenterol. 2003 Oct;37(4):299-302. • Freeman HJ. Natural history and clinical behavior of Crohn's disease extending beyond two decades. J Clin Gastroenterol. 2003 Sep;37(3):216-9. • Freeman HJ. Biopsy-defined adult celiac disease in Asian-Canadians. Can J Gastroenterol. 2003 Jul;17(7):433-6. • Chung HV, Ramji A, Davis JE, Chang S, Reid GD, Salh B, Freeman HJ, Yoshida EM. Abdominal pain as the initial and sole clinical presenting feature of systemic lupus erythematosus. Can J Gastroenterol. 2003 Feb;17(2):111-3. • Freeman HJ. Appendiceal carcinoids in Crohn's disease. Can J Gastroenterol. 2003 • Freeman HJ. Collagenous sprue associated with an extensive T-cell lymphoma. J Clin Gastroenterol. 2003 Feb;36(2):144-6. Lam, Dr. Eric C • Lam ECS, Brown JA, Whittaker JS, Esophageal perforation causing direct aortic injury, Can J Gastroenterol 2003 Feb;17(2):115-7. • Lam ECS, Bailey RJ, Infliximab as salvage therapy after cyclosporine in severe ulcerative
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colitis, Can J Gastroenterol 2003 Mar;17(3):198-200. • Lam EC, Bailey RJ. Infliximab salvage therapy after cyclosporine in an acute flare of chronic ulcerative colitis. Can J Gastroenterol. 2003 Mar;17(3):198-200. • Lam EC, Brown JA, Whittaker JS. Esophageal foreign body causing direct aortic injury. Can J Gastroenterol. 2003 Feb;17(2):115-7. Salh, Dr. Baljinder Singh • Farah M, Parhar K, Moussavi M, Eivemark S, Salh B. 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis. Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G919-28. Epub 2003 Jul 03. • Marotta A, Parhar K, Moussavi M, Salh B. Characterisation of integrin-linked kinase signaling in colonic cancer. Br J Cancer. 2003:88:1755-1762. • Hundal RS, Gomez-Munoz A, Salh B, Marotta A, Duronio V, Steinbrecher UP. Oxidized low density lipoprotein inhibits macrophage blocking ceramide generation, thereby maintaining protein kinase B activation and Bcl-XL levels. J Biol Chem. 2003;278:24399-24408 • Parhar K, Ray A, Steinbrecher U, Nelson C, Salh B. The p38 mitogen-activated protein kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells. Immunology. 2003;108(4):502-512. • Gomez-Munoz A, Kong J, Salh B, Steinbrecher U. Sphingosine-1-phosphate inhibits acid sphingo-myelinase and blocks apoptosis in macrophages. FEBS Lett. 2003 Mar • Salh B, Assi K, Templeman V, Parhar K, Owen D, Gomez-Munoz A, Jacobson K. Curcumin attenuates DNB-induced murine colitis. Am J Physiol 2003;285: G235-243. • Chung H, Ramji A, Davis J,Gillet L, Reid G, Salh B, Freeman H, Yoshida E. Abdominal pain as the initial and sole clinical presenting feature of systemic lupus erythematosus. Can J of Gastroenterology. 2003 Feb;17(2):111-113. • Farah M, Parhar K, Moussavi M, Eivemark S and Salh B. Apigenin and DRB sensitize HCT116 cells to TNFalpha-mediated apoptosis. Am J Physiol Epub July 2003
Steinbrecher, Dr. Urs P • Gomez-Munoz A, Kong JY, Salh B, Steinbrecher UP. Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages. J Lipid Res. 2004 Jan;45(1):99-105. Epub 2003 Oct 01. • Chan H, Lougheed M, Laher I, Steinbrecher UP. Oxidized low-density lipoprotein inhibits endothelium-dependent vasodilation by an antioxidant-sensitive, lysophosphatidylcholine-independent mechanism. J Cardiovasc Pharmacol. 2003 • Hundal RS, Gomez-Munoz A, Kong JY, Salh BS, Marotta A, Duronio V, Steinbrecher UP. Oxidized low density lipoprotein inhibits macrophage apoptosis by blocking ceramide generation, thereby maintaining protein kinase B activation and Bcl-XL levels. J Biol Chem. 2003 Jul 4;278(27):24399-408. Epub 2003 May 15. • Parhar K, Ray A, Steinbrecher U, Nelson C, Salh B. The p38 mitogen-activated protein kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells. Immunology. 2003 Apr;108(4):502-12. • Gomez-Munoz A, Kong J, Salh B, Steinbrecher UP. Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages. FEBS Lett. 2003 Mar
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Tai, Dr. Isabella T • Davies FE, Dring AM, Li C, Rawstron AC, Shammas MA, O'Connor SM, Fenton JA, Hideshima T, Chauhan D, Tai IT, Robinson E, Auclair D, Rees K, Gonzalez D, Ashcroft AJ, Dasgupta R, Mitsiades C, Mitsiades N, Chen LB, Wong WH, Munshi NC, Morgan GJ, Anderson KC. Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis. Blood. 2003 Dec 15;102(13):4504-11. Epub 2003 Aug 28. Whittaker, Dr. John S • Lam EC, Brown JA, Whittaker JS. Esophageal foreign body causing direct aortic injury. Can J Gastroenterol. 2003 Feb;17(2):115-7. Yoshida, Dr. Eric M • Sirrs S, Yoshida EM, Wong LTK, Erb SR, Steinbrecher UP, Chung SW, Scudamore CH, Harnett C, Lillquist Y, Davidison AGJ. Orthotopic Liver transplantation in the treatment of a patient with carbamyl phosphate synthetase deficiency and cystic fibrosis. Pediatric and Child Health 2003; 8:97-98. • Canadian Liver Transplant Study Group: Scudamore C, Erb S, Yoshida EM, Kneteman N, Bain V, Ghent C, Moratta P, Grant D, Greig P, Lilly L, Tchervenkov J, Barkun J, Roy A, Marleau D, McAlister V, Peltekian K. Early Steroid Withdrawal Following Liver Transplantation: The Canadian Tacrolimus vs Microemulsion Cyclosporine A Trial: 1 year follow up. Liver Transplantation 2003; 9:587-595 • Chung HV, Ramji A, Davis JE, Gillett L, Reid GD, Salh B, Freeman HJ, Yoshida EM. Abdominal Pain as the Initial and Sole Clinical Presenting Feature of Systemic Lupus Erythematosus. Canadian Journal of Gastroenterology 2003; 17: 111-113. • Gill S, Shah A, Le N, Cook EF, Yoshida EM. Asian ethnicity-related differences in gastric cancer presentation and outcome among patients treated at a Canadian cancer center. Journal of Clinical Oncology 2003; 21: 2070-76. • Yoshida EM. Requiem for a journal. CMAJ. 2003 May 13;168(10):1237; discussion 1237-8. • Rasenack J, Zeuzem S, Feinman SV, Heathcote EJ, Manns M, Yoshida EM, Swain MG, Gane E, Diago M, Revicki DA, Lin A, Wintfeld N, Green J. Peginterferon alpha-2a (40kD) [Pegasys] improves HR-QOL outcomes compared with unmodified interferon alpha-2a [Roferon-A]: in patients with chronic hepatitis C. Pharmacoeconomics. 2003;21(5):341-349. • Yoshida EM. Tumour markers and cirrhosis: the CA-125 who came in from the cold. Can J Gastroenterol. 2003 Feb;17(2):118. • Bain VG, Wong WW, Greig PD, Yoshida EM; Canadian Association of Gastroenterology. Hepatology and the Canadian gastroenterologist: interest, attitudes and patterns of practice: results of a national survey from the Canadian Association of Gastroenterology. Can J Gastroenterol. 2003 Jan;17(1):25-9.
General Internal Medicine
Hatala, Dr Rose • Hatala R, Brooks LR, Norman GR. Practice makes perfect: the critical role of mixed practice in the acquisition of ECG interpretation skills. Advances in Health Sciences Education. 2003;
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8(1): 17-26. Holmes, Dr. Cheryl L • Holmes CL, Walley KR. Bad Medicine: Low dose dopamine in the ICU. Chest 2003; 123(4): 1266-75. • Holmes CL, Russell JA, Walley KR. Genetic polymorphisms in sepsis and septic shock: Role in prognosis and potential for therapy. Chest 2003; 124(3): 1103-15. • Holmes CL, Landry DW, Granton JT. Science review: Vasopressin and the cardiovascular system part 1 - receptor physiology. Crit Care 2003; 7(6):427-434. Khan, Dr. Nadia A • McAlister FA, Khan NA, Straus SE, Papaiokim M, Fisher BW, Majumdar SR, Gajic O, Daniel M, Tomlinson G. The accuracy of the history , physical exam and routine tests in predicting post-operative pulmonary complications (The CARE-PREOP1 Study) Am J Resp Crit Care Med 2003;167(5):741-4 • Feldman R. on Behalf of the Canadian Hypertension Education Program. What's new in the 2003 hypertension guidelines? Perspectives in Cardiology. 2003;19(6):44-51 Magee, Dr. Laura A • von Dadelszen P, Magee LA, Roberts JM. Subclassification of preeclampsia. Hypertens Preg 2003;22:143-148 • Cham C, von Dadelszen P, Waterman EJ, Magee LA. Is hydralazine the drug of choice for severe hypertension in pregnancy? A meta-analysis of clinical trials. Br Med J 2003;327:955 • Chandra K, Magee L, Einarson A, Koren G. Nausea and vomiting in pregnancy: results of a survey that identified interventions used by women to alleviate their symptoms. J Psychosom Obstet Gynecol 2003;24:71-75 • von Dadelszen P, Alasaly K, Krajden M, Magee LA, Popovska V, Devarakonda RM, Money D, Patrick DM, Brunham R. Titres of antibodies against cytomegalovirus and Chlamydia pneumoniae are increased in early-onset pre-eclampsia, compared with late-onset pre-eclampsia, normotensive intrauterine growth restriction, and normal pregnancy. Br J Obstet Gynaecol 2003;110(8):725-30 Palepu, Dr. Anita • Brogly SB, Mercier C, Bruneau J, Palepu A, Franco EL. Towards More Effective Public Health Programming For Injection Drug Users: Development and Evaluation of the Injection Drug User Quality of Life Scale. Substance Use and Misuse. 2003; 38 (7): 965-92. • Jackson VA, Palepu A, Szalacha L, Caswell C, Carr PL, Inui T. "Having the right chemistry": A Qualitative study of mentoring in academic medicine. Academic Medicine 2003; 78(3): • Palepu A, Sun H,Kuyper L, Schechter MT, O'Shaughnessy MV, Anis AH. Factors associated with hospital readmission among HIV-infected persons in the era of HAART. Journal of General Internal Medicine 2003; 18 (4): 242-247. • Palepu A, Tyndall MW, Li K, Yip B, Schechter MT, O'Shaughnessy MV, Montaner JSG, Hogg RS. Alcohol use and incarceration adversely affects HIV-1 RNA suppression among injection drug users starting antiretroviral therapy. Journal of Urban Health 2003; 80 (4):667-75. • Flegel KM, Palepu A. Life on the wards. Canadian Medical Association Journal. 2003; 168 (8): 997-8 • Palepu A, Horton NB, Tibbetts N, Dukes K, Samet JH. Substance abuse treatment and
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emergency department utilization among a cohort of HIV-infected persons with alcohol problems. Journal of Substance Abuse Treatment, 2003; 25(1):37-42 • Kerr T, Wood E, Palepu A, Wilson D, Schechter MT, Tyndall MW. Responding to an explosive HIV-epidemic driven by frequent cocaine injection: Is there a role for safe injecting facilities? Journal of Drug Issues 2003; 33 (3): 579-608. • Kerr T, Wood E, Small D, Palepu A, Tyndall MW. Feasibility of safer injecting facilities among injection drug users in Vancouver's Downtown Eastside (Fast-Track). Canadian Medical Association Journal 2003; 169 (8): 759-63. • Kerr T, Wood E, Palepu A, Small D, Tyndall MW. Feasibility of safer injection facilities in Vancouver's Downtown Eastside. CMAJ Oct 2003;169(8):759-63. • Kerr T, Wood E, Palepu A, Wilson D, Schechter MT, Tyndall MW. Responding to explosive HIV epidemics driven by frequent cocaine injection: Is there a rold for safer injecting facitlites? J Drug Issues 2003; 33(3):579-608. Wright, Dr. James (Jim) M • Ticea C, Wright JM. Prescribing Caution; When a simple disease isn't so simple. Can Fam Physician. 2003;49:176-177 • Wright JM, Musini V, van Breemen M, Jauca CD. Update on combined HRT. Can Fam Physician 2003;49:599 • McCormack J, Rangno R, Wright JM. Thiazides first-line treatment for hypertension. Can Fam Physician 2003;49:879 • Wakefield J, Herbert CP, Maclure M, Dormuth C, Wright JM, Legare J, Brett-MacLean P, Premi J. Commitment to change statements can predict actual change in practice. J Contin Educ Health Prof 2003;23:81-93
Geriatric Medicine
Madden, Dr. Kenneth M • Stratton JR, Levy W, Caldwell J, Jacobson A, May J, Matsuoka D, Madden K. Cardiovascular responses to parasympathetic withdrawal. Journal of the American College of Cardiology. 41(11):2077-83, 2003. Meneilly, Dr. Graydon S • Meneilly GS, Habener JF, Egan JM, Tildesley H, Greig N, Elahi D. Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patient with diabetes. Diabetes Care, 26:2835-2841, (2003) • Josse RG, Chiasson J-L, Ryan EA, Lau DCW, Ross SA, Yale J-F, Leiter LA, Maheux P, Tessier D, Wolever TMS, Gerstein H, Rodger NW, Dornan JM, Murphy LJ, Rabasa-Lhoret R, Meneilly GS. Acarbose in the treatment of elderly patients with type 2 diabetes. Diabetes Res Clin Practice. 59; 37-42 (2003) • Egan JM. Meneilly GS, Elahi D. Effects of One Month Bolus Subcutaneous Administration of Exendin-4 in Type 2 Diabetes. Am J Physiol. 284:E1072-1079, (2003) • Meneilly GS, McIntosh CHS, Pederson RA, Habener JF, Ehlers MRW, Egan JM Elahi D. Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type-1 diabetes. Diabetes Care 26:837-842, (2003)
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• Cuff DJ, Meneilly GS, Martin A, Ignaszewski A, Tildesley H, Frohlich J. Effective exercise modality to reduce insulin resistance in women with type 2 diabetes. Diabetes Care 26:2977-2982, (2003) • Ryan AS, Berman DM, Nicklas BJ, Sinha M, Gingerich RL, Meneilly GS, Egan JM, Elahi D. Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity. Diabetes Care 26:2383-2388, (2003) • Meneilly GS and multiple authors. Canadian Diabetes Association 2003 Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada. Canadian Journal of Diabetes. 27 (Suppl 2): (2003) • Meneilly GS. Peaks and valleys in older adults: What should our targets be and how do we attain them? IJCP - Suppl 138; November: 30-35 (2003) Wong, Dr. Roger Y • Wong RYM. Patients' length of stay, discharge outcome, and readmission rate in a specialized acute care for elders unit. Annals Royal College of Physicians and Surgeons of Canada 2002;35(8):579-585 • Wong RYM, Shaw M, Acton C, Wilbur K, McMillan M, Breurkens E, Sowden C, Trautman SM, Chan N. An interdisciplinary approach to optimize health services in a specialized acute care for elders (ACE) unit. Geriatrics Today: Journal of the Canadian Geriatrics Society 2003; 6(3):177-186.
Hematology
Barnett, Dr. Michael J • Forrest DL, Nevill TJ, Naiman SC, Le A, Brockington DA, Barnett MJ, Lavoie JC, Nantel SH, Song KW, Shepherd JD, Sutherland HJ, Toze CL, Davis JH & Hogge DE. Second malignancy following high-dose therapy and autologous stem cell transplantation: incidence and risk factor analysis. Bone Marrow Transplant 32:915-923, 2003. • Taussig DC, Davies AJ, Cavenagh JD, Oakervee H, Syndercombe-Court D, Kelsey S, Amess JAL, Rohatiner AZS, Lister TA & Barnett MJ. Durable remissions of myelodysplastic syndrome and acute myeloid leukemia after reduced-intensity allografting. J Clin Oncol • Couban S & Barnett M. The source of cells for allografting. Biol Blood Marrow Transplant 9:669-673, 2003. • Khoury H, Dalal BI, Nevill TJ, Horsman DE, Barnett MJ, Shepherd JD, Toze CL, Conneally EA, Sutherland HJ, Hogge DE & Nantel SH. Acute myelogenous leukemia with t(8;21) - Identification of a specific immunophenotype. Leuk Lymphoma 44:1713-1718, 2003. Eaves, Dr. Allen C • Jorgensen HG, Allan EK, Jiang X, Liakopoulou E, Richmond L, Eaves CJ, Eaves AC & Holyoake TL. Stage-specific alterations in serum levels of G-CSF in chronic myeloid leukaemia. Leukemia 17: 1430-1432, 2003. • Jiang X, Stuible M, Chalandon Y, Li A, Chan WY, Eisterer W, Krystal G, Eaves A & Eaves C. Evidence for a poisitive role of SHIP in the BCR-ABL-mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia. Blood 102: 2976-2984, 2003.
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Forrest, Dr. Donna L • Daly A, Song K, Nevill T, Nantel S, Toze C, Hogge D, Forrest D, Lavoie J, Sutherland H, Shepherd J, Hasegawa W, Lipton J, Messner H, Kiss T. Stem cell transplantation for myelofibrosis: a report from two Canadian centers. Bone Marrow Transplantation 32(1):35-40, 2003. • Forrest DL, Thompson K, Couban SH, Dorcas VG & Pierce R. Low molecular weight heparin for the prevention of hepatic veno-occlusive disease (VOD) after hematopoietic stem cell transplantation: A prospective phase II study. Bone Marrow Transplantation 31(12):1143-9, 2003. • Forrest DL, Nevill TJ, Naiman SC, Le A, Brockington DA, Barnett MJ, Lavoie JC, Nantel SH, Song KW, Shepherd JD, Sutherland HJ, Toze CL, Davis JH, & Hogge DE. Second malignancy following high-dose therapy and autologous stem cell transplantation: incidence and risk factor analysis. Bone Marrow Transplantation, 32(9):915-23, 2003. • El Seisi S, Gupta R, Clase CM, Forrest DL, Milandinovic M, & Couban S. Renal pathology at autopsy in patients who died after hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation, 9:683-688, 2003. Galbraith, Dr. Paul • Kuruvilla J, Leitch HA, Vickars LM, Galbraith PF, Li CH, Al-Saab S, Naiman SC. Aplastic anemia following administration of a tumor necrosis factor-alpha inhibitor. Eur J Haematol 71(5):396-8, 2003. Hogge, Dr. Donna • Daly A, Song K, Nevill T, Nantel S, Toze C, Hogge D, Forrest D, Lavoie J, Sutherland H, Shepherd J, Hasegawa W, Lipton J, Messner H, Kiss T. Stem cell transplantation for myelofibrosis: a report from two Canadian centers. Bone Marrow Transplantation 32(1):35-40, 2003. • Forrest DL, Nevill TJ, Naiman SC, Le A, Brockington DA, Barnett MJ, Lavoie JC, Nantel SH, Song KW, Shepherd JD, Sutherland HJ, Toze CL, Davis JH, & Hogge DE. Second malignancy following high-dose therapy and autologous stem cell transplantation: incidence and risk factor analysis. Bone Marrow Transplantation, 32(9):915-23, 2003. • Feuring-Buske M, Gerhard B, Cashman J, Humphries RK, Eaves CJ & Hogge DE. Improved engraftment of human acute myeloid leukemia (AML) progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors. Leukemia 17:760-3, 2003. • Black JH, McCubrey JA, Willingham MC, Ramage J, Hogge DE & Frankel AE. Diphtheria toxin-interleukin 3 fusion protein (DT(338)IL3) prolongs disease-free survival of leukemic immunocompromised mice. Leukemia 17:155-9, 2003. • Guan Y, Gerhard B & Hogge DE. Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML). Blood 101:3142-9, 2003. • Pineault N, Buske C, Feuring-Buske M, Abramovich C, Rosten P, Hogge DE, Aplan PD, Humphries RK. Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis 1. Blood 101:4529-38, 2003. • Zhang Y, Dawson MI, Ning Y, Polin L, Parchment RE, Corbett T, Mohamed AN, Feng KC, Farhana L, Rishi AK, Hogge D, Leid M, Peterson VJ, Zhang XK, Mohammad R, Lu JS, Willman C, VanBuren E, Biggar S, Edelstein M, Eilender D, Fontana JA. Induction of
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apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog. Blood 102(10):3743-52, 2004. Humphries, Dr. Richard K • Feuring-Buske M, Gerhard B, Cashman J, Humphries RK, Eaves CJ & Hogge DE. Improved engraftment of human acute myeloid leukemia (AML) progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors. Leukemia 760-763, 2003. • Baran CP, Tridandapani S, Helgason CD, Humphries RK, Krystal G & Marsh CB. The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity. J Biol Chem 278: 38628-38636, 2003. • Bjornsson JM, Larsson N, Brun AC, Magnusson M, Andersson E, Lundstrom P, Larsson J, Repetowska E, Ehinger M, Humphries RK & Karlsson S. Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4. Mol Cell Biol 23: 3872-3883, 2003. • Brun ACM, Fan X, Björnsson JM, Humphries RK & Karlsson S. Enforced adenoviral vector-mediated expression of HOXB4 in human umbilical cord blood cd34(+) cells promotes myeloid differentiation but not proliferation. Mol Ther 8: 618-628, 2003. • Crow AR, Song S, Freedman J, Helgason CD, Humphries RK, Siminovitch KA & Lazarus AH. IVIg-mediated amelioration of murine ITP via Fc?RIIB is independent of SHIP1, SHP-1 and Btk activity. Blood 102: 558-560, 2003. • Helgason CD, Antonchuk J, Bodner C & Humphries RK. Homeostatis and regeneration of the hematopoietic stem cell pool are altered in SHIP-deficient mice. Blood 102: 3541-3547, 2003. • Krosl J, Austin P, Beslu N, Kroon E, Humphries RK & Sauvageau G. In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein. Nat Med 9: 1428-1432, 2003. • Krosl J, Beslu N, Mayotte N, Humphries RK & Sauvageau G. The competitive nature of HOXB4-transduced HSC is limited by PBX1: the generation of ultra-competitive stem cells retaining full differentiation potential. Immunity 18: 561-571, 2003. • Larrivée B, Lane DR, Pollet I, Olive PL, Humphries RK & Karsan A. Vascular endothelial growth factor receptor-2 induces survival of hematopoietic progenitor cells. J Biol Chem 278: 22006-22013, 2003. • Pineault N, Buske C, Feuring-Buske M, Abramovich C, Rosten P, Hogge DE, Aplan PD & Humphries RK. Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1. Blood 101: 4529-4538, 2003. Lansdorp, Dr. Peter M • Baerlocher GM, Mak J, Roth A, Rice KS & Lansdorp PM. Telomere shortening in leukocyte subpopulations from baboons. J Leuk Biol 73: 289-296, 2003. • Brummendorf TH, Ersoz I, Hartmann U, Bartolovic K, Balabanov S, Wahl A, Paschka P, Kreil S, Lahaye T, Berger U, Gschaidmeier H, Bokemeyer C, Hehlmann R, Dietz K, Lansdorp PM, Kanz L & Hochhaus A. Telomere length in peripheral blood granulocytes reflects response to treatment with imatinib in patients with chronic myeloid leukemia. Blood (Letter) 101: 375-376, 2003. • Tchirkov A & Lansdorp PM. Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia. Hum Mol Genet 12: 227- 232, 2003. • Baerlocher GM, Roth A & Lansdorp PM. Telomeres in hematopoietic stem cells. Ann N Y Acad Sci 996: 44-48, 2003.
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• Baerlocher GM & Lansdorp PM. Telomere length measurements in leukocyte subsets by automated multicolor flow-FISH. Cytometry 55A: 1-6, 2003. • Fogarty PF, Yamaguchi H, Wiestner A, Baerlocher GM, Sloand E, Zeng WS, Read EJ, Lansdorp PM & Young NS. Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Lancet (Research Letter) 362: 1628-1630, 2003. • McBurney MW, Yang X, Jardine K, Hixon M, Boekelheide K, Webb JR, Lansdorp PM & Lemieux M. The mammalian SIR2a protein has a role in embryogenesis and gametogenesis. Mol Cell Biol 23: 38-54, 2003. • Ning Y, Xu J-F, Li Y, Chavez L, Riethman HC, Lansdorp PM & Weng N-P. Telomere length and the expression of natural telomeric genes in human fibroblasts. Hum Mol Genet 12: 1329-1336, 2003. • Röth A, Yssel H, Pène J, Chavez EA, Schertzer M, Lansdorp PM, Spits H & Luiten RM. Telomerase levels control the life span of human T lymphocytes. Blood 102: 849-857, 2003. • Van Ziffle JAG, Baerlocher GM & Lansdorp PM. Telomere length in subpopulations of human hematopoietic cells. Stem Cells 21: 654-660, 2003. • Yamaguchi H, Baerlocher GM, Lansdorp PM, Chanock SJ, Nunez O, Sloand E & Young NS. Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome. Blood 102: 916-918, 2003. • Röth A, Vercauteren S, Sutherland HJ & Lansdorp PM. Telomerase is limiting the growth in acute myeloid leukemia cells. Leukemia 17:2410-2417, 2003.
Lavoie, Dr. Julye C • Daly A, Song K, Nevill T, Nantel S, Toze C, Hogge D, Forrest D, Lavoie J, Sutherland H, Shepherd J, Hasegawa W, Lipton J, Messner H, Kiss T. Stem cell transplantation for myelofibrosis: a report from two Canadian centers. Bone Marrow Transplantation 32:35-40, 2003. • Khoury H, Poh CF, Williams M, Lavoie JC, Nevill TJ. Acute myelogenous leukemia complicated by acute necrotizing ulcerative gingivitis due to Aspergillus terreus. Leukemia and Lymphoma 44:709-713, 2003. • Forrest DL, Nevill TJ, Naiman SC, Le A, Brockington DA, Barnett MJ, Lavoie JC, Nantel SH, Song KW, Shepherd JD, Sutherland HJ, Toze CL, Davis JH, Hogge DE. Second malignancy following high-dose chemo/radiotherapy and autologous stem cell transplantation: Incidence and risk factor analysis. Bone Marrow Transplant 9(32):915-923, 2003. Nantel, Dr. Stephen H • Forrest DL, Nevill TJ, Naiman SC, Le A, Brockington DA, Barnett MJ, Lavoie JC, Nantel SH, Song KW, Shepherd JD, Sutherland HJ, Toze CL, Davis JH, Hogge DE. Second malignancy following high-dose chemo/radiotherapy and autologous stem cell transplantation: Incidence and risk factor analysis. Bone Marrow Transplant 9(32):915-923, 2003. • Khoury H, Dalal BI, Nevill TJ, Horsman DE, Barnett MJ, Shepherd JD, Toze CL, Conneally EA, Sutherland HJ, Hogge DE & Nantel SH. Acute myelogenous leukemia (AML) with t(8;21) - Identification of a specific immunophenotype. Leukemia & Lymphoma 44(10):1713-1718, 2003. • Khoury H, Dalal BI, Nantel SH. Intravascular lymphoma presenting with bone marrow involvement and leukemic phase. Leukemia and Lymphoma 44(6):1043-1047, 2003 • Daly A, Song K, Nevill T, Nantel S, Toze C, Hogge D, Forrest D, Lavoie J, Sutherland H,
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Shepherd J, Hasegawa W, Lipton J, Messner H, Kiss T. Stem cell transplantation for myelofibrosis: a report from two Canadian centers. Bone Marrow Transplantation 2003; 32:35-40. • Oikonomou A, Muller NL, Nantel S. Radiographic and high-resolution CT findings of influenza virus pneumonia in patients with hematologic malignancies. Am J Roentgenol 181:507-511, 2003. • Khoury H, Lestou VS, Gascoyne RD, Bruyere H, Li CH, Nantel SH, Dalal BI, Naiman SC, Horsman DE. Multicolor Karyotyping and Clinicopathological Analysis of Three Intravascular Lymphoma Cases. Mod Pathol 16(7):716-724, 2003. Nevill, Dr. Thomas J • Forrest DL, Nevill TJ, Naiman SC, Le A, Brockington DA, Barnett MJ, Lavoie JC, Nantel SH, Song KW, Shepherd JD, Sutherland HJ, Toze CL, Davis JH and Hogge DE. Second malignancy following high-dose chemo/radiotherapy and autologous stem cell transplantation: Incidence and risk factor analysis. Bone Marrow Transplant 32(9):915-923, 2003. • Daly A, Song K, Nevill T, Nantel S, Toze C, Hogge D, Forrest D, Lavoie J, Sutherland H, Shepherd J, Hasegawa W, Lipton J, Messner H, Kiss T. Stem cell transplantation for myelofibrosis: a report from two Canadian centers. Bone Marrow Transplantation 32:35-40, 2003. • Khoury H, Dalal BI, Nevill TJ, Horsman DE, Barnett MJ, Shepherd JD, Toze CL, Conneally EA, Sutherland HJ, Hogge DE & Nantel SH. Acute myelogenous leukemia (AML) with t(8;21) - Identification of a specific immunophenotype. Leukemia & Lymphoma 44(10):1713-1718, 2003. Shepherd, Dr. John D • O'Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F, Cornelissen JJ, Fischer T, Hochhaus A, Hughes T, Lechner K, Nielsen JL, Rousselot P, Reiffers J, Saglio G, Shepherd J, Simonsson B, Gratwohl A, Goldman JM, Kantarjian H, Taylor K, Verhoef G, Bolton AE, Capdeville R, Druker BJ. Interferon and low-dose cytarabine compared with Imatinib for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 348: 994-1004, 2003. • Forrest DL, Nevill TJ, Naiman SC, Le A, Brockington DA, Barnett MJ, Lavoie JC, Nantel SH, Song KW, Shepherd JD, Sutherland HJ, Toze CL, Davis JH, Hogge DE. Second malignancy following high-dose chemo/radiotherapy and autologous stem cell transplantation: Incidence and risk factor analysis. Bone Marrow Transplant 32(9):915-923, 2003. • Khoury H, Dalal BI, Barnett MJ, Horsman DE, Shepherd JD, Hogge DE, Toze CL, Sutherland HJ, Nevill TJ, Conneally EA & Nantel SH. Acute myelogenous leukemia (AML) with translocation 8;21 (T(8;21))-Identification of a specific immunophenotype. Leuk Lymphoma 44(10):1713-1718, 2003 • Daly A, Song K, Nevill T, Nantel S, Toze C, Hogge D, Forrest D, Lavoie J, Sutherland H, Shepherd J, Hasegawa W, Lipton J, Messner H, Kiss T. Stem cell transplantation for myelofibrosis: a report from two Canadian centers. Bone Marrow Transplantation 32:35-40, 2003. Smith, Dr. Clayton A • Rizzieri DA, Talbot JT, Long GW, Vredenburgh JW, Gasparetto C, Smith C, Colvin MO, Adams D, Morris A, Dodge R, Loftis J, Waters-Pick B, Reese M, Carawan H and Chao N. 4-hydroperoxycyclophosphamide purged peripheral blood stem cells for autologous transplantation in patients with acute myeloid leukemia. Biol Blood and Marrow Transplant, 9:183- 188, 2003. • Smith C. Hematopoietic stem cells and hematopoiesis. Cancer Control 10:9-16, 2003. • Fallon P, Kerr W, Gentry T, Balber A, Ludeman S, Storms R and Smith C. Hematopoietic
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progenitors which express high levels of aldehyde dehydrogenase can be counted and enriched from mobilized peripheral blood. Br J Hematology 112:99-108, 2003. • Nimmanapalli R., Fuino L, Gasparetto M, Glozak M, Tao J, Moscinski L, Smith C, Wu J, Jove R, Atadja P, Bhalla K. Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or refractory chronic myelogenous leukemia-blast crisis cells. Cancer Research 63(16):5126—35, 2003. • Long GW, Maden B, Kurtzberg J, Rubinstein P, Gasparetto C, Rizzieri D, Smith C, Vredenburgh J, Halperin E, Broadwater G, Niedzweiki D & Chao NJ. Unrelated umbilical cord blood transplantation in adult patients. Biology of Blood and Marrow Transplantation 9:772-80, 2003. Song, Dr. Kevin W • Daly A, Song K, Nevill T, Nantel S, Toze C, Hogge D, Forrest D, Lavoie J, Sutherland H, Shepherd J, Hasegawa W, Lipton J, Messner H, Kiss T. Stem cell transplantation for myelofibrosis: a report from two Canadian centers. Bone Marrow Transplantation 32 (1):35-40, 2003. • Song KW, Mollee P, Keating A, Crump M. Autologous stem cell transplant for relapsed and refractory peripheral t-cell lymphoma: variable outcome according to pathologic subtype. British Journal of Haematology 120: 978-985, 2003. • Forrest DL, Nevill NJ, Naiman SC, Le A, Brockington DA, Barnett MJ, Lavoie JC, Nantel SJ, Song KW, Shepherd JD, Sutherland HJ, Toze CL, Davis JH & Hogge DE. Secondary malignancy following high-dose therapy and autologous stem cell transplantation: incidence and risk factor analysis. Bone Marrow Transplantation 32(9):915-924, 2003. Sutherland, Dr. Heather J • Daly A, Song K, Nevill T, Nantel S, Toze C, Hogge D, Forrest D, Lavoie J, Sutherland H, Shepherd J, Hasegawa W, Lipton J, Messner H, Kiss T. Stem cell transplantation for myelofibrosis: a report from two Canadian centers. Bone Marrow Transplantation 32(1):35-40, 2003. • Forrest DL, Nevill TJ, Naiman SC, Le A, Brockington DA, Barnett MJ, Lavoie JC, Nantel SH, Song KW, Shepherd JD, Sutherland HJ, Toze CL, Davis JH, & Hogge DE. Second malignancy following high-dose therapy and autologous stem cell transplantation: incidence and risk factor analysis. Bone Marrow Transplantation, 32(9):915-23, 2003. • Roth A, Vercauteren S, Sutherland HJ, Lansdorp PM. Telomerase is limiting the growth of acute myeloid leukemia cells. Leukemia 17:2410-7, 2003. Toze, Dr. Cynthia L • Daly A, Song K, Nevill T, Nantel S, Toze C, Hogge D, Forrest D, Lavoie J, Sutherland H, Shepherd J, Hasegawa W, Lipton J, Messner H, Kiss T. Stem cell transplantation for myelofibrosis: a report from two Canadian centers. Bone Marrow Transplantation 32:35-40, 2003. • Forrest DL, Nevill TJ, Naiman SC, Le A, Brockington DA, Barnett MJ, Lavoie JC, Nantel SH, Song KW, Shepherd JD, Sutherland HJ, Toze CL, Davis JH, Hogge DE. Second malignancy following high-dose chemo/radiotherapy and autologous stem cell transplantation: Incidence and risk factor analysis. Bone Marrow Transplant 9(32):915-923, 2003. • Khoury H, Dalal BI, Nevill TJ, Horsman DE, Barnett MJ, Shepherd JD, Toze CL, Conneally EA, Sutherland HJ, Hogge DE & Nantel SH. Acute myelogenous leukemia (AML) with t(8;21) - Identification of a specific immunophenotype. Leukemia & Lymphoma 44(10):1713-1718, 2003.
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Vickars, Dr. Linda M • Kuruvilla J, Leitch HA, Vickars LM, Galbraith PF, Li CH, Al-Saab S, Naiman SC. Aplastic anemia following administration of a tumor necrosis factor-alpha inhibitor. Eur J Haematol 71(5):396-8, 2003.
Infectious Diseases
Av-Gay, Dr. Yossef Y • Newton GL, Koledin T, Rwat M, Gorovitz B, Fahey RC, and Av-Gay Y. (2003). The Glycosyltransferase Gene Encoding the Enzyme Catalyzing the First Step of Mycothiol Biosynthesis (mshA). J Bacteriology. 185: 3476-3479. • Rawat M, Kovacevic S, Billman-Jacobe H, and Av-Gay Y. (2003). Inactivation of mshB, a key gene in mycothiol biosyntheses pathway in Mycobacterium smegmatis. Microbiology 149:1341-1349. • Rawat M, Heys J and Av-Gay Y. (2003). Identification and characterization of a diamide sensitive mutant of Mycobacterium smegmatis. FEMS. Microbiol. Lett. 220:161-169. • Karlsgot Hestvik, A. L. Hmama, Z. and Av-Gay, Y. (2003). Kinome analysis of host response to mycobacterial infection. Infection and Immunity. 71:5514-5522. • Maynes, J.T., Garen, C., Cherney, M.M., Newton, G.L., Arad, D., Av-Gay, Y., Fahey, R.C., and James, M.N.G. (2003). The Crystal Structure of 1-D-myo-inosityl-2-amino-2-deoxy-a-D-glucopyranoside Deacetylase (MshB) from Mycobacterium tuberculosis Reveals a Zinc Hydrolase with a Lactate Dehydrogenase Fold. J. Biol. Chem. 21;278:47166-70. • Steffek, M., Newton, G. L., Av-Gay, Y., and Fahey, R.C. (2003). Characterization of Mycobacterium tuberculosis Mycothiol S- conjugate Amidase. Biochemistry. 42: 12067-12076. Brunham, Dr. Robert C • Karunakaran KP, Noguchi Y, Read TD, Cherkasov A, Lu H, Zhou X, Shen C, Brunham RC. Molecular analysis of the multiple GroEL proteins of Chlamydiae. J Bacterial 2003;185:1958-1966. • Cohen CR, Gichui J, Rukaria R, Nguti R, Sinei SS, Gaur L, Brunham RC. Immunogenetic correlates for Chlamydia trachomatis-associated tubal infertility. Obstet Gynecol 2003;101:438-444. • Rekart MJ, Patrick DM, Chakraborty B, Maginley JJL, Jones HD, Pourbohlouol B, Brunham RC. A trial of mass treatment with oral Azithromycin to control an outbreak of Syphilis. Lancet. 2003 Jan 25; 361 (9354):313-314. • Luo M, Ramdahin S, Iqbal S, Jacobson K, Narayansingh MJ, Schroeder M, Brunham RC, Embree J, Plummer FA. High resolution sequence-based DPB1 typing identified two novel DPB1 alleles, DPB1*9401 and DPB1*9501, from Kenya population. Tissue Antigens 2003 Aug; 62(2):182-4. • von Dadelszen P, Magee LA, Krajden M, Alasaly K, Popovska V, Devarakonda R, Money D, Patrick D, Brunham RC, von Dadelszen. Levels of antibodies against cytomegalovirus and Chlamydia pnemoniae are increased in early onset pre-eclampsia, compared with late onset pre-eclampsia, normotensive intrauterine growth restriction, and normal pregnancy. BJOG. 2003 Aug; 110(8):725-30. • Rekart ML, Rekart JT, Patrick DM, Brunham RC. International Health: Five reasons why
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Canadians should get involved. CJPH 2003 July/August:94(4); 258-259. • Paavonen J, Karunakaran KP, Yasuyuki N, Anttila T, Bloigu A, Dillner J, Hallmans G, Hakulinen T, Jellum E, Koskela P, Lehtinen M, Thoresen S, Brunham RC. Serum antibody response to the HSP60s of Chlamydia trachomatis in women with cervical cancer. Am J Obstet Gynecol 2003 Nov; 189(5):1287-92. • Ness RB, Goodman M, Shen C, Brunham RC. Serologic Evidence of Past Infection with C. trachomatis in Relation to Ovarian Cancer. J Infect Dis. 2003; 187:1147-52 • Read TD, Myers GSA, Brunham RC, Nelson WC, Paulsen IT, Heidelberg J, Holtzapple E, Khouri H, Federova NB, Carty HA, Umayam LA, Haft DH, Peterson J, Beanan MJ, McClarty G, Hsia R, Rank RG, Bavoil PM, Fraser CM. Genome sequence of Chlamydophila Caviae (Chlamydia Psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae. Nucleic Acid Res. 2003 Apr 15;31(8):2134-47. • Skowronski DM, Lu H, Warrington R, Hegele R, De Serres G, Hayglass K, Stark D, White R, MacNabb J, Li Y, Manson HE, Brunham RC. Does antigen-specific cytokine response correlate with the experience of oculo-respiratory syndrome after influenza vaccine? J Infec Dis 2003;187:495-499 • Pourbohlouol B, Rekart MJ, Brunham RC. Impact of mass treatment on syphilis transmission: A mathematical modeling approach. Sex Trans Dis. 2003 apr 15;30(4):297-305. • Patrick DM, Champagne S, Goh SH, Arsenault G, Thomas E, Shaw C Rahim T, Taha F, Bigham M, Dubenko V, Skowronski D, Brunham RC. Distribution of Neisseria meingitidis Carriage during an outbreak of Serogroup C disease. Clin Infec Dis 2003 Nov; 37(9):1183-1188. • Poutanen SM, Low DE, Henry B, Finkelstein S, Rose D, Green K, Tellier R, Draker R, Adachi D, Ayers M, Chan AK, Skowronski DM, Salit I, Simor AE, Slutsky AS, Doyle PW, Krajden M, Petric M, Brunham RC, McGeer AJ. Identification of Severe Acute Respiratory Syndrome in Canada. N Engl J Med 2003 May 15;348(20):1948-51 • Marra MA, Jones SJM, Astell C, Holt R, Brooks-Wilson A, Butterfield Y, Asano J, Barber S, Chan S, Cloutier A, Coughlin S, Freeman D, Girn N, Griffith O, Khattra J, Leach S, Mayo M, McDonald H, Montgomery S, Pahdoh P, Petrescu A, Robertson G, Schein J, Smailus D, Stott J, Yang GS, Siddiqui A, Plummer F, Andonov A, Artsob H, Bastien N, Bernard K, Booth T, Bowness D, Drebot M, Fernando L, Flick R, Garbutt M, Gray M, Grolla A, Jones S, Feldmann H, Meyers A, Kabani A, Li Y, Normand S, Stroher U, Tipples GA, Tyler S, Vogrig R, Ward D, Watson B, Brunham RC, Krajden M, Petric M, Skowronski DM, Upton C, Roper RL. The Genome sequence of the SARS-Associated Coronavirus. Science 2003 May 30;300(5624):1399-404.
Burdge, Dr. David R • Burdge DR, Money DM, Forbes JC, Walmsley SL, Smaill FM, Boucher M, Samson LM, Steben M, on behalf of the Canadian HIV Trials Network Working Group on Vertical HIV Transmission. Canadian consensus guidelines for the management of pregnant HIV-positive women and their offspring. CMAJ 2003; 168: 1683-8 Full Guideline online at www.cmaj.ca • Burdge DR, Money DM, Forbes JC, Walmsley SL, Smaill FM, Boucher M et al. Canadian consensus guidelines for the management of pregnant HIV-positive women and their offspring. CMAJ 2003; 168: 1671-4. • Burdge DR, Money DM, Forbes JC, Walmsley SL, Smaill FM, Boucher M et al. Canadian consensus guidelines for the care of HIV-positive pregnant women: putting recommendations into practice. CMAJ 2003; 168: 1683-8. • Money DM, Arikan YY, Remple V, Sherlock C, Craib K, Birch P, Burdge DR. Genital tract
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and plasma human immunodeficiency virus viral load throughout the menstrual cycle in ovulatory women who are infected with human immunodeficiency virus. Am J Obstet Gynecol 2003: 188: 122-127. • Alimenti A, Burdge DR, Ogilvie GS, Money DM, Forbes JC. Lactic acidemia in human immunodeficiency virus-uninfected infants exposed to perinatal intiretroviral therapy. Pediatr Infect Dis J 2003; 22(9):782-788. • O'Connell JM, Braitstein P, Hogg RS, Yip A, Craib KJP, O'Shaughnessy MV, Montaner JSG, Burdge DR. Differences in virologic supression among men and women enrolled in a population-based antiretroviral drug treatment program. Accepted for publication by the Journal of Anitviral Therapy. 2003; 8(6): 569-576. Cherkasov, Dr. Artem • K.P. Karunakaran, Y. Noguchi, T.D. Read. A. Cherkasov, H. Lu, C. Shen, R.C. Brunham. Molecular Analysis of the Multiple GroEL homologs of Chlamydiae. J Bacteriol., 186,6, 1958-66 (2003). • D. Nandan, A. Cherkasov, T. Yi, N.E. Reiner. Molecular Cloning and Chararcterization of Elongation Factor-1 from Leishmania donovani Reveals Structural and Functional Differences from host EF-1. Biochem Biophys Res Commun 302, 4, 646-52 (2003). • Cherkasov. Inductive Electronegativity Scale. Iterative Calculation of Inductive Partial Charges. J. Chem. Inf. Comp. Sci., 43, 2039-2047 (2003). • A Cherkasov, D. Sprous, R. Chen. 3D Correlation Analysis – New Method of Quantification of Substituent Effect. J. Phys. Chem. A, 107, 9695-9704 (2003). Chow, Dr. Anthony W • Kwok AYC, Chow AW. Phylogenetic study of Staphylococcus and Macrococcus species by DNA sequence analysis of a partial hsp60 gene encoding the 60 kDa heat shock protein. Internat J System Evol Microbiol, 53:1-6, 2003. • Chan KCW, Chow AW. Management of septic shock- current concepts. Hong Kong J Paediatr 8:3-14. 2003. • Cameron SB, Stolte EH, Chow AW, Savelkoul HFJ: T helper cell polarization as a measure of the maturation of the immune response. Mediators of Inflammation 12:285-292, 2003 Grigg, Dr. Michael • ME Grigg and Y Suzuki. (2003) Clonal emergence of virulent strains of Toxoplasma gondii. Microbes Infect. 5:685-690 • M.E. Grigg*, J.T. Kong*, L. Uyetake, S. Parmley and J.C. Boothroyd (2003). Serotyping of Toxoplasma gondii infections in humans using synthetic peptides. J. Infect. Dis. 187:1484-1495. *joint first-authors. Harrigan, Dr. Paul R • Wood E, Hogg RS, Yip B, Harrigan PR, O'Shaughnessy MV, Montaner JSG. Is there CD4 cell count that precludes a survival response to modern antiretroviral therapy. AIDS 2003;17(5):711-720. • Wood E, Hogg RS, Yip B, Harrigan PR, O' Shaughnessy MV, Montaner JSG. Effect of medication adherence of survival of HIV-infected adults who start highly active antiretroviral therapy when the CD4+ cell count is 0.200 to 0.350 x 109 cells/L. Ann Intern Med. 2003 Nov 18;139(10);810-6.
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• Wood E, Hogg RS, Yip B, Quercia R, Harrigan PR, O' Shaughnessy MV, Montaner JSG. Higher baseline levels of plasma human immunodeficiency virus type 1 RNA are associated with incresed mortality after initiation of triple-drug antiretroviral therapy. JID 2003;188(10):1421-1425. • Brumme ZL, Dong WW, Chan KJ, Hogg RS, Montaner JSG, O'Shaughnessy MC, Harrigan PR. Influence of ploymorphisms with in CX3CR1 and MDR-1 genes on initial antiretroviral therapy response. AIDS. 2003 Jan 24;17(2):201-8. • Lee N, Hogg RS, Yip B, Harrigan PR, Harris M, O'Shaughnessy MV, Montaner JSG. Rates of disease progression among Human Immunodeficiency Virus-Infected persons initiating mutiple-drug rescue therapy. JID 2003;188:137-41. • Montaner JSG, Cote HCF, Harris M, Hogg RS, Yip B, Chan J, Harrigan PR, O'Shaughnessy MV. Mitochondrial toxicity in the era of HAART: Evaluating venuous lactate and peripheral blood mitochondrial DNA in HIV-infected patients taking antiretroviral therapy. JAIDS 2003;24:S85- 90. • Cote H, Yip C, Asselin J, Chan J, Hogg RS, Harrigan PR, O'Shaughnessy MV, Montaner JSG. Mitochondrial: Nuclear DNA ratios in peripheral blood cells from Human Immunodeficiency Virus (HIV)-infected patients who received selected HIV antiretroviral drug regimens. JID 2003;187:1972-6. • Alexander CS, Asselin JJ, Ting L, Montaner JSG, Hogg RS, Yip B, O'Shaughnessy MV, Harrigan PR. Antiretroviral concentrations in untimed plasma samples predict therpy outcome in population with advanced disease. JID 2003; 188(4):541-8. • Harrigan PR, Hertogs K, Verbiest W, Larder B, Yip B, Brumme ZL, Alexander C, Tilley J, O'Shaughnessy MV, Montaner JSG. Modest decreases in NNRTI susceptibility do not influence virologic outcome in patients receiving initial NNRTI-containing triple therapy. Antiviral Therapy. 2003 Oct; 8(5): 395-402. • Davani EY, Brumme Z, Singhera GK, Cote HC, Harrigan PR, Dorscheid DR. Insulin-like growth factor-1 protects ischemic murine myocardium from ischemia/reperfusion associated injury. Crit Care. 2003 Dec;7(6):R176-83. Epub 2003 Oct 10. • Galli RA, Sattha B, Wynhoven B, O'Shaughnessy MV, Harrigan PR. Sources and magnitude of intralaboratory variability in a sequence-based genotypic assay for human immunodeficiency virus type 1 drug resistance. J Clin Microbiol. 2003 Jul;41(7):2900-7. • Chan KC, Galli RA, Montaner JS, Harrigan PR. Prolonged retention of drug resistance mutations and rapid disease progression in the absence of therapy after primary HIV infection. AIDS. 2003 May 23;17(8):1256-8. • Brumme ZL, Chan KJ, Dong WW, Wynhoven B, Mo T, Hogg RS, Montaner JS, O'Shaughnessy MV, Harrigan PR. Prevalence and clinical implications of insertions in the HIV-1 p6Gag N-terminal region in drug-naive individuals initiating antiretroviral therapy. Antivir Ther. 2003 Apr;8(2):91-6. Hmama, Dr. Zakaria • Hestvik ALK, Z Hmama, Y Av-Gay. Kinome analysis of host response to mycobacterial infection: a novel technique in proteomics. Infect Immun, 2003, 71:5514-5522 • Lee JS, Hmama Z, Mui A, Reiner NE. Stable gene silencing in human monocytic cell lines using lentiviral-delivered siRNA: Silencing of the p110alpha isoform of phosphoinositides 3-kinase reveals differential regulation of adherence induced by 1alpha, 25 dihydroxycholecalciferol and bacterial lipopolysacharide. J Biol Chem. 2003 Dec 12 [Epub ahead of print]
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• Z Hmama, Sendide K, Talal A, Garcia R, Dobos K, Neil Reiner N. Quantitative analysis of phagosome maturation in macrophages: Inhibition by lipoarabinomannan and rescue by a vitamin D3/ phosphatidylinositol 3-kinase pathway. J Cell Sci, 2004, 117:2131-2140. Montaner, Dr. Julio S • Harrigan PR, Hertogs K, Verbiest W, Larder B, Yip B, Brumme ZL, Alexander C, Tilley J, O'Shaughnessy MV, Montaner JSG. Modest Decreases in NNRTI Susceptibility Do Not Influence Virologic Outcome in Patients Receiving Initial NNRTI-containing Triple Therapy. Antiviral Therapy. Antiviral Therapy 2003; 8(5): 395-402. • Lee N, Hogg R, Yip B, Harrigan R, Harris M, O'Shaughnessy MV, Montaner JSG. Rates of disease progression among Human Immunodeficiency Virus-Infected persons initiating multiple-drug rescue therapy. Journal of Infectious Diseases 2003; 188:137-41. • Montaner JSG, Cote HCF, Harris M, Hogg R, Yip B, Chan J, Harrigan R, O'Shaughnessy MV. Mitochondrial toxicity in the era of HAART: Evaluating venuous lactate and peripheral bloof mitochondrial DNA in HIV-infected patients taking antiretroviral therapy. JAIDS 2003; 34:S85-90. • Harris M, Montaner JSG, et al. Efficacy and durability of neviraprine in antiretroviral-experienced patients. JAIDS 2003; 34:S53-58. • Brumme ZL, Dong WW, Chan KJ, Hogg RS, Montaner JSG, O'Shaughnessy MV, Harrigan PR. Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response. AIDS 2003 Jan 24;17(2):201-8. • Braitstein P, Yip B, Heath KV, Levy AR, Montaner JSG, Humphries K, Kiely FM, O'Shaughnessy MV, Hogg RS. Interventional cardiac procedures among HIV-infected individuals on antiretroviral therapy 1995-2000. AIDS 2003;17:1-5 • Cote H, Yip B, Asselin J, Chan J, Hogg R, Harrigan R, O'Shaughnessy MV, Montaner JSG. Mitochondrial: Nuclear DNA ratios in peripheral blood cells from Human Immunodeficiency Virus (HIV)-infected patients who received selected HIV antiretroviral drug regimens. Journal of Infectious Diseases 2003; 187:1972-6. • Wood E, Hogg RS, Yip B, Harrigan PR, O'ShaughnessY MV, Montaner JSG. Is there a CD4 cell count that precludes a survival response to modern antiretroviral therapy? AIDS 2003;17(5):711-720. • Wood E, Tyndall M, Spittal P, Li K, Hogg R, Montaner JSG, O'Shaughnessy M, Schechter M. Supply-side illicit drug control policy in the face of the HIV and Overdose epidemics: Investigation of a massive heroin seizure. Can Med Assoc J. 2003;168:165-9. • Wood E, Kerr T, Tyndall M, Spittal P, Li K, Hogg R, Montaner JSG, O'Shaughnessy MV, Schechter M. Potential public health and community impacts of safer injecting facilities: Evidence from a cohort of injecting drug users. J Acquir Immune Defic Syndr. 2003;32:2-8. • Wood E. Montaner JSG, Yip B, Tyndall M, Schechter MT, O'Shaughnessy MV, Hogg RS. Adherence and virological responses to HAART among HIV-infected injection drug users. CMAJ 2003 Sep 30;169(7):656-61. • Montessori V, Harris M, Montaner JSG. Hepatoxicity of nucleoside reverse trascriptase inhibitors. Seminars in Liver Disease 2003; 23(2). • Braitstein P, Yip B, Heath KV, Levy A, Montaner JSG, Humphries K, Kielyc FM, O'Shaughnessy MV, Hogg RS. Interventional cardiovascular procedures among HIV-infected individuals on antiretroviral therapy 1995-2000. AIDS 2003; 17:2071-75. • Wood E, Montaner JSG, Yip B, Tyndall M, Schechter MT, O'Shaughnessy MV, Hogg RS. Adherence and plasma HIV RNA responses to highly active antiretroviral therapy among HIV-1
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infected injection drug users. CMAJ 2003;169(7):656-61 • Wood E, Montaner JSG, Yip B, Tyndall M, Schechter MT, O'Shaughnessy MV, Hogg RS. Prevalence and Correlates of Untreated Human Immunodeficiency Virus Type 1 Infection among Persons Who Have Died in the Era of Modern Antiretroviral Therapy. Jounal of Infectious Diseases 2003; 188(8):1164-1170. • Alexander CS, Asselin JJ, Ting L, Montaner JSG, Hogg RS, Yip B, O'Shaughnessy MV, Harrigan RS. Antiretroviral concentrations in untimed plasma samples predict therapy outcome in a population with advanced disease. Journal of Infectious Diseases 2003; 188(4):541-8. • Wood E, Hogg RS, Yip B, Quercia R, Harrigan PR, O'Shaughnessy MV, Montaner JSG. Higher baseline plasma HIV-1 RNA levels are asociated with increased mortality after the initiation of triple-drug antiretroviral therapy. Journal of Infectious Diseases 2003; 188(10):1421-5. • Wood E, Hogg RS, Yip B, Harrigan PR, O'Shaughnessy MV, Montaner JSG. Effect of medication adherence on survival of HIV-infected adults who start highly active antiretroviral therapy when the CD4+ cell count is 0.200 to 0.350 x 10(to the 9th power) cells/L. Annals Internal Medicine 2003; 139(10):810-16. • Bedell R, Heath K, Hogg RS, Wood E, Press N, Yip B, O'Shaughnessy MV, Montaner JSG. Total lymphocyte count as a possible surrogate of CD4 cell count to prioritize eligibility for antiretroviral therapy among HIV-infected individuals in resource-limited settings. Antiviral Therapy 2003; 8:379-384 • Delgado J, Heath K, Yip B, Marion S, Alfonso V, O'Shaughnessy MV, Montaner JSG, Hogg RS. Highly active antiretroviral therapy: physician experience and enhances adherence to prescription refill. Antiviral Therapy 2003; 8:471-478. • O'Connell J, Braitstein P, Hogg RS, Yip B, Craib K, O'Shaughnessy MV, Montaner JSG, Burdge D. Age, adherence and injection drug use predict virological suppression among men and women enrolled in a population-based antiretroviral drug treatment program. Antiviral Therapy 2003; 8:569-576. • Wood E, Montaner JSG, Bangsberg DR, Tyndall MW, Stathdee SA, O'Shaughnessy MC, Hogg RS. Extending access to HIV antiretroviral therapy among marginalized populations in the developed world. AIDS 2003 Nov 21;17(17):2419-2427. • Wood E, Hogg RS, Yip B, O'Shaughnessy MV, Montaner JSG. CD4 cell count response to non-nucleoside reverse transcriptase inhibitor- or protease inhibitor-based highly active antretroviral therapy in an observational cohort study. JAIDS 2003 Nov 1;34(3):347-8. • Wood E, Hogg RS, Heath KV, De La Roas R, Lee N, Yip B, O'Shaughnessy MV, Montaner JSG. Provider bias in the selection of non-nucleoside reverse transcriptase inhibitor and protease inhibitor-based highly active antiretroviral therapy and HIV treatment outcomes in observational studies. AIDS. 2003 Dec 5; 17(18):2629-2634. • Brumme ZL, Chan KJ, Dong W, Wynhoven B, Mo T, Hogg RS, Montaner JSG. Prevalence and clinical implication of insertions in the HIV-1 p6gag N-terminal region in drug naïve individuals initiating antiretroviral therapy. Antiviral Therapy 2003;8:91-96. Montessori, Dr. Valentina C • Montessori V, Harris M, Montaner JSG. Hepatoxicity of nucleoside reverse transcriptase inhibitors. Seminars in Liver Disease 2003;23(2):167-171 Phillips, Dr. Peter • Kunimoto DY, Peppler MS, Talbot J, Phillips P, Shafran SD, and the Canadian HIV Trials
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Network Protocol 010 Study Group. Analysis of Mycobacterium avium complex isolates from blood samples of AIDS patients by pulsed-field gel electrophoresis. J Clin Microb 2003;41(1):498-9. • Keogh CF, Brown JA, Phillips P, Cooperberg PL. Renal mucormycosis in an AIDS patient: imaging features and pathologic correlation. Am J Roentgenology 2003;180:1278-1280. Press, Dr. Natasha M
• Bedell R, Heath KV, Hogg RS, Wood E, Press N, Yip B, O'Shaughnessy MC, Montaner JSG. Total lymphocyte count as a possible surrogate of CD4 cell count to priortize eligibility for antiretroviral therapy among HIV-infected individuals in resouce-limited settings. Antiviral Therapy 2003;8:397-384. Reiner, Dr. Neil E • Sly LM, Hingley-Wilson SM, Reiner NE and McMaster WR. Survival of Mycobacterium tuberculosis in host macrophages involves resistance to apoptosis dependent upon induction of anti-apoptotic Bcl-2 family member Mc1-1. J Immunol. 2003; 170: 430-437. • Nandan D, Cherkasov A, Sabouti R, Yi T and Reiner NE. Molecular cloning, biochemical and structural analysis of elongation factor-1alpha from Leishmania donovani: comparison with the mammalian homologue, Biochem. Biophys. Res. Commun. 2003; 302: 646-652. • Lopez M, Sly LM, Lu Y, Young D, Cooper H and Reiner NE. The 19 kDa Mycobacterium tuberulosis protein induces macrophage apoptosis through Toll-like receptor-2. J. Immunol. 2003; 170: 2409-2416. Rekart, Dr. Michael L • Rekart ML, Patrick DM, Chakraborty B, Maginley JLJ, Jones HD, Bajdik CD, Pourbohoul B, Brunham RC. Targeted mass treatment for syphilis with oral azithromycin. Lancet 2003; 361 (9354): 313-14. • Pourbohloul B, Rekart ML, Brunham RC. Impact of mass treatment on syphilis transmission: A mathematical modelling approach. Sexually Transmitted Diseases, 2003; 30 (4):297-305. • Jayaraman G. C, Gleeson T, Rekart M. L. et al Prevalence and determinants of HIV-1 Subtypes in Canada: Enhancing Routinely Collected Information Through the Canadian HIV Strain and Drug Resistance Surveillance Program. February 15, 2003; Vol 29-04.(peer reviewed). • Stajduhar KI, Poffenroth L, Wong E, Archibald CP, Sutherland D, Rehart M. Missed Opportunities: Injection drug use and HIV/AIDS in Victoria, Canada. International Journal of Drug Policy. International Journal of Drug Policy 2004; 15(2004), 171-181. • Rekart ML. The Impact of HIV reporting on HIV pretest counseling. BC Med Journal. 2003; 45(3). Steiner, Dr. Theodore S • Alcantara CS, Yang CH, Steiner TS, Barrett LJ, Lima AA, Chappell CL, Okhuysen PC, White AC Jr, Guerrant RL. Interleukin-8, tumor necrosis factor-alpha, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis. Am. J. Trop. Med. Hyg. 2003; 68:325-8 Stiver, Dr. H. G • Stiver G. The treatment of influenza with antiviral drugs. Can Med Assoc J 2003;168:49-57 • Marra F, Marra CA, Stiver HG. A case for rimantadine to be marketed in Canada for the
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prophylaxis of influenza A virus infection. Can Respir J 2003;10:381-8 • Conly JM, Stiver HG, Weiss KA, Becker DL, Rosner AJ, Miller ME. A retrospective analysis of practice patterns in the treatment of methicillin-resistant Staphylococcus aureus skin and soft tissue infections at three Canadian tertiary care centres. Can J Infect Dis 2003;14:315-21 Tyndall, Dr. Mark W • Tyndall MW, Currie S, Spittal PM, Li K, Wood E, O'Shaughnessy MV, Schecter MT. Intensive injection cocaine use a primary risk factor in the Vancouver HIV-1 epidemic. AIDS 2003, 32(5):522-526. • Wood E, Tyndall MW, Spittal PM, Li K, Anis AH, Hogg RS, Montaner JSG, O'Shaughnessy MV, Schecter MT. The impact of supply-side drug policy in the fact of an HIV epidemic: An investigation of a massive Canadian heroin seizure CMAJ 2003; 168(2): 165-169. • Craib KJ, Spittal PM, Wood E, Laliberte N, Hogg RS, Li K, Heath K, Tyndall MW, O'Shaughnessy MV, Schecter MT. Risk factors for elevated HIV incidence among Aboriginal injection drug users in Vancouver. CMAJ 2003; 168(1):19-24. • Wood E, Kerr T, Spittal PM, Li K, Small W, Tyndall MW, Hogg RS, O'Shaughnessy MV, Schecter MT. The potential public health and community impacts of safer injecting facilities: evidence from a cohort of injection drug users. J Acquir Immune Defic Syndr 2003; 32(1): 2-8. • Tyndall MW. Impact of supervised injection facilites on community HIV levels: A public health perspective. Expert Review on Anti-infective Therapy 2003, 1:543-549. • Wood E, Montaner JS, Bangsberg D, Tyndall M, Strathdee S, O'Shaughnessy MV, Hogg RS. Expanding access to HIV antiretroviral therapy among marginalized populations in the developed world. AIDS 2003, 17:2419-2427. • Wood E, Montaner JS, Tyndall MW, Schechter MT, O'Shaughnessy MV, Hogg RS. Prevalence and correlates of untreated Human Immunodeficiency Virus Type 1 infection among persons who have died in the era of modern antiretroviral therapy. J Infect Dis. 2003, 188(8):1164-70. • Wood E, Montaner JS, Yip B, Tyndall MW, Schechter MT, O'Shaughnessy MV, Hogg RS. Adherence and virological responses to HAART among HIV-infected injection drug users. Can Med Assoc J. 2003, 169(7):656-661. • Wood E, Kerr T, Small W, Schechter MT, Tyndall MW. The impact of police presence on access to needle exchange programs. J Acquir Immune Defic Syndr. 2003, 34(1):116-118. • Spittal PM, Bruneau J, Craib KJ, Miller C, Lamothe F, Weber AE, Li K, Tyndall MW, O'Shaughnessy MV, Schechter MT. Surviving the sex trade: a comparison of HIV risk behaviours among street-involved women in two Canadian cities who inject drugs. AIDS Care 2003, 15:187-95. • Wood E, Kerr T, Smalll W, Spittal P, Hogg R, Tyndall MW, O'Shaughnessy M, Schechter M. Evaluation of an 'unsanctioned' peer-run syringe exchange program. Journal of Urban Health 2003, 80(3):455-64. • Braitstein P, Li K, Tyndall M, Spittal P, O'Shaughnessy MV, Schilder A, Johnston C, Hogg RS, Schechter MT. Sexual violence among a cohort of injection drug users. Soc Sci Med 2003, 57(3): 561-569. • Wood E, Tyndall M, Schechter M. Drug supply and drug abuse. Can Med Assoc J 2003;168(9):1113. • Palepu A, Tyndall MW, Yip B, O'Shaughnessy MV, Hogg RS, Montaner JS. Impaired virologic response to highly active antiretroviral therapy associated with ongoing injection drug
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use. J Acquir Immune Defic Syndr 2003, 32(5):522-526. • Weber AE, Tyndall MW, Spittal PM, Li K, Coulter S, O'Shaughnessy MV, Schechter MT. High pregnancy rates and reproductive health indicators among female injection-drug users in Vancouver, Canada. Eur J Contracept Reprod Health Care 2003, 8(1):52-58. • Wood E, Kerr T, Spittal P, Tyndall M, O'Shaughnessy M, Schechter M. The Heathcare and Fiscal Costs of the Illicit Drug Use Epidemic: The Impact of Conventional Drug Control Strategies, and the Potential of a Comprehensive Approach. BC Med Journal 2003;45(3):130-136. • Wood E, Tyndall M, Spittal P, Li K, Hogg R, Montaner JSG, O'Shaughnessy M, Schechter M. Supply-side illicit drug control policy in the face of the HIV and Overdose epidemics: Investigation of a massive heroin seizure. CMAJ 2003;168:165-9 • Tyndall MW, Spittal PM, Wood E, Laliberte N, Li K, O'Shaughnessy MV, Schechter MT. Intensive Injection Cocaine Use as a Primary Risk Factor of HIV Seroconversion amoung Polydrug Users in Vancouver. AIDS 2003;17(6):887-893. • Wood E, Spittal PM, Kerr T, Small W, Tyndall MW, O'Shaughnessy MV, Schechter MT. Requiring help injection as a risk factor for HIV infection in the Vancouver epidemic: implication for HIV prevention. Can J Public Health. 2003 Sep-Oct;94(5):355-9. • Kerr T, Wood E, Palepu A, Small D, Tyndall MW. Feasibility of safer injection facilities in Vancouver's Downtown Eastside. CMAJ Oct 2003;169(8):759-63. • Kerr T, Wood E, Palepu A, Wilson D, Schechter MT, Tyndall MW. Responding to explosive HIV epidemics driven by frequent cocaine injection: Is there a rold for safer injecting facitlites? J Drug Issues 2003; 33(3):579-608.
Medical Oncology
Chi, Dr. Kim N • Ada Man, Tom Pickles, Kim N. Chi. Asian Race and Impact on Outcomes after Radical Radiotherapy for Localized Prostate Cancer. Journal of Urology 170:901-904, 2003. • Gleave M, Nelson C, Chi K. Antisense targets to enhance hormone and cytotoxic therapies in advanced prostate cancer. Curr Drug Targets. 4 (3):209-21, 2003. • C.A. Townsley, K. Chi, D.S. Ernst, K. Belanger, I. Tannock, G.A. Bjarnason, D. Stewart, R. Goel, J.D. Ruether, L.L. Siu, J. Jolivet, L. McIntosh, L. Seymour, M.J. Moore. Phase II Study of Troxacitabine (BCH-4556) in Patients With Advanced and/or Metastatic Renal Cell Carcinoma: A Trial of the National Cancer Institute of Canada-Clinical Trials Group. Journal of Clinical Oncology, 21: 1524-1529, 2003 • DS Ernst, IF Tannock, EW Winquist, PM Vener, L Reyno, MJ Moore, K Chi, K Ding, C Elliot, W Parulekar. Randomized, Placebo-Controlled Trial Of Mitoxantrone/Prednisone and Clodronate Versus Mitoxantrone/ Prednisone Alone In Patients With Hormone Refractory Prostate Cancer and Pain. J Clin Oncol, 21:3335-3342, 2003 • Zellweger T, Kiyama S, Chi K, Miyake H, Adomat H, Skov K, Gleave ME. Overexpression of the cytoprotective protein clusterin decreases radiosensitivity in the human LNCaP prostate tumour model. BJU International 92(4):463-9, 2003. Connors, Dr. Joseph M • Duggan DB, Petroni GR, Johnson JL, Glick JH, Fisher RI, Connors JM, Canellos GP, Peterson
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BA. Randomized comparison of ABVD and MOPP/ABV hybrid for the treatment of advanced Hodgkin's disease: report of an intergroup trial. J Clin Oncol 2003;21(4):607-14. • Rosenwald A, Wright G, Wiestner A, Chan WC, Connors JM, Campo E, Gascoyne RD, Grogan TM, Muller-Hermelink HK, Smeland EB, Chiorazzi M, Giltnane JM, Hurt EM, Zhao H, Averett L, Henrickson S, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Montserrat E, Bosch F, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Fisher RI, Miller TP, LeBlanc M, Ott G, Kvaloy S, Holte H, Delabie J, Staudt LM. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell 2003;3(2):185-97. • Lestou VS, Ludkovski O, Connors JM, Gascoyne RD, Lam WL, Horsman DE. Characterization of the recurrent translocation t(1;1)(p36.3;q21.1-2) in non-Hodgkin lymphoma by multicolor banding and fluorescence in situ hybridization analysis. Genes Chromosomes Cancer 2003;36:375-81. • Armitage JO, Carbone PP, Connors JM, Levine A, Bennett JM, Kroll S. Treatment-related myelodysplasia and acute leukemia in non-Hodgkin's lymphoma patients. J Clin Oncol 2003;21:897-906. • Horsman DE, Okamoto I, Ludkovski O, Le N, Harder L, Gesk S, Siebert R, Chhanabhai M, Sehn L, Connors JM, Gascoyne RD. Follicular lymphoma lacking the t(14;18)(q32;q21): identification of two disease subtypes. Brit J Haematol 2003;120:424-33. • Kouroukis CT, Belch A, Crump M, Eisenhauer E, Gascoyne RD, Meyer R, Lohmann R, Lopez P, Powers J, Turner R, Connors JM. Flavopiridol in untreated or relapsed mantle-cell lymphoma: results of a phase II study of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2003;21:1740-5 • Rosenwald A, Wright G, Leroy K, Yu X, Gaulard P, Gascoyne RD, Chan WC, Zhao T, Haioun C, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Campo E, Montserrat E, Lopez-Guillermo A, Ott G, Muller-Hermelink HK, Connors JM, Braziel R, Grogan TM, Fisher RI, Miller TP, LeBlanc M, Chiorazzi M, Zhao H, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Staudt LM. Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J Exp Med. 2003;198:851-62. • Connors JM. Hodgkin's lymphoma: the hazards of success. J Clin Oncol. 2003;21:3388-90. • Lestou VS, Gascoyne RD, Sehn L, Ludkovski O, Chhanabhai M, Klasa RJ, Husson H, Freedman AS, Connors JM, Horsman DM. Multi-color fluorescence in-situ hybridization assessment of t(14;18) positive follicular lymphoma and band-by-band correlation with gene expression and clinical outcome. Brit J Haematol 2003;122:745-59. • Volker D, Stein H, Connors JM. Hodgkin’s Lymphoma: Biology and Treatment Strategies from Primary, Refractory, and Relapsed Disease. Hematology (Am Soc Hematol Educ Program). 2003;:225-47. • Grigg AP, Connors JM. Primary adrenal lymphoma. Clin Lymphoma. 2003 Dec;4(3):154-60. • Leitch HA, Gascoyne RD, Chhanabhai M, Voss NJ, Klasa R, Connors JM. Limited-stage mantle-cell lymphoma. Ann Oncol. 2003 Oct;14:1555-61.
Ellard, Dr. Susan L • Propper DJ, de Bono J, Saleem A, Ellard SL, Flanagan E, Paul J, Ganesan TS, Talbot DC, Aboagye EO, Price P, Harris AL, Twelves C. Use of positron emission tomography in
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pharmacokinetic studies to investigate therapeutic advantage in a phase I study of 120-hours intravenous infusion XR5000. Journal of Clinical Oncology. 21(2):203-10, 2003 Jan 15. Hoskins, Dr. Paul J • Hoskins PJ. Small cell carcinoma of the cervix: 14 years experience at a single institution using a combined modality regimen of involved field irradiation and platinum-based combination chemotherapy. J Clin Oncol 21:3495-501, 2003 Klasa, Dr. Richard J • Zucca E, Conconi A, Mughal TI, Sarris AH, Seymour JF, Vitolo U, Klasa R, et al. Patterns of outcome and prognostic factors in primary large-cell lymphoma of the testis in a survey by the international extranodal lymphoma study group. J Clin Oncol 2003; 21(1): 20-27. • Lestou VS, Gascoyne RD, Sehn L, Ludkovski O, Chhanabhai M, Klasa RJ, et al. Multicolour fluorescence in situ hybridization analysis of t(14;18)-positive follicular lymphoma and correlation with gene expression data and clinical outcome. British Journal of Haematology. 2003;122(5):745-59. • Au Wing Y, Gascoyne Randy D, Gallager Richard E, Le Nhu, Klasa Richard J, Liang Raymond HS, Choy Carolyn, Foo William, Connors Joseph M. Hodgkin's lymphoma in Chinese migrants to British Columbia: a 25-year survey. Annals of Oncology 2003. • Leitch HA, Gascoyne RD, Chhanabhai M, Voss NJ, Klasa R, Connors JM. Limited - stage mantle-cell lymphoma. Annals of Oncology 2003; 14:1555-61 Murray, Dr. Robert Nevin C • Erridge SC, Murray N. Thoracic radiotherapy for limited-stage small cell lung cancer: Issues of timing, volumes, dose and fractionation. Semin Oncol 30; 26-37, 2003. • Gill S, Murray N, Dalmau J, Thiessen B. Paraneoplastic sensory neuronopathy and spontaneous regression of small cell lung cancer. Can J Neurol Sci 30:269-271, 2003 Norris, Dr. Brian D • Gelmon KA, Vandenberg TA, Panesci L, Norris B, Crump M, Douglas L, Walsh W, Matthews SJ and Seymour LK. A phase II study of ZD0473 given as a short infusion every 3 weeks to patients with advanced or metastatic breast cancer. A National CancInstitute of Canada - Clinical Trials Group (NCIC CTG) trial - IND 129. Annals of Oncology 14:543-548, 2003 • Dranitsaris G, Norris B, Hanna W, O'Malley F, Gelmon K. Identifying the optimal timing of HER-2 testing in patients with breast cancer: a Canadian economic evaluation. Current Oncology 2003;10:36-44 Swenerton, Dr. Kenneth D • Seiden MV, Swenerton KD, Matulonis U, Rose P, Batist G, Ette E, Garg V, Harding MW, Charpentier D. A phase II study of the MDR inhibitor biricodar (INCEL, VX710) and paclitaxel in women with advanced ovarian cancer refractory to paclitaxel therapy. Gynecol Oncol 2002; 86(3): 302-310 • Oza AM, Elit L, Swenerton KD, Faught W, Ghatage P, Carey M, McIntosh L, Dorr A, Holmlund JT, Eisenhauer E. Phase II study of CGP 69846A (ISIS 5132) in recurrent epithelial ovarian cancer. An NCIC CTG study (NCIC IND.116). Gyn Oncol 2003; 89:129-133 • Piccart MJ, Bertelsen K, Stuart G, Cassidy J, Mangioni C, Simonsen E, James K, Kaye S, Vergote I, Blom R, Grimshaw R, Atkinson R, Swenerton K, Trope C, Nardi M, Kaern J,
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Tumolo S, Timmers P, Roy JA, Lhoas F, Lidvall B, Bacon M, Birt A, Andersen J, Zee B, Paul J, Pecorelli S, Baron B, McGuire W. Long term follow-up confirms a survival advantage of the paclitaxel-cisplatin regimen over the cyclophosphamide-cisplatin combination in advanced ovarian cancer. Int J Gyn Cancer 2003; 13:144-148 • Foulkes WD, Narod SA, Swenerton K, Panabaker K, Gilbert L. Re: Gynecologic surgeries and risk of ovarian cancer in women with BRCA1 and BRCA2 Ashkenzi founder mutations: an Israeli population-based case-control study. J Natl Cancer Inst 2003; 95:1640 • Hoskins PJ, Swenerton KD, Pike JA, Lim P, Aquino-Parsons C, Wong F and Lee N. Small-cell carcinoma of the cervix: fourteen years of experience at a single institution using a combined-modality regimen of involved-field irradiation and platinum-based combination chemotherapy. J Clin Oncol 2003; 21: 3495-3501 Weinerman, Dr. Brian H • Brian H. Weinerman, MD. Johanna den Duyf, RN and G. Anne Hughes, RN Calling Long-Distance Is teleconcology the future of rural cancer treatment? Oncology Exchange Vol. 2 No. 3 August 2003 • Lim J, Truong P, Berthelet E, Pai H, Wai E, Joe H, Larsson S, Kader S, Weinerman B, Wilson K and Olivotto I. Endoscopic response predicts for survival and organ preservation after primary chemo-radiotherapy for esophageal cancer. Int J Radiat Oncol Biol Phys 57:1328-35, 2003. Wilson, Dr. Kenneth S • Lim JT, Truong PT, Berthelet E, Pai H, Joe H, Wai E, Larsson S, Kader HA, Weinerman B, Wilson KS, Olivotto O. Endoscopic response predicts for survival and organ preservation after primary chemo-radiotherapy for esophageal cancer. Int J Rad Onc Biol Phys 2003, 57, 5, 1328-1335.
Nephrology
Gill, Dr. John S • Gill JS, Pereira BJG, Chronic Kidney Disease: Implication for the Transplant Recipient. Blood Purification. 2003 Jan 21;1: (137-42). • Gill JS, Pereira BJG. Death in the first year after kidney transplantation: Implications for the transplant waiting list. Transplantation. 2003 Jan 15; 75(1): 113-7. • Gill JS, Tonelli M, Mix C and Pereira BJG, The Effect Of Maintenance Immunosuppression On Kidney Allograft Function. Kidney International, 2004, Vol. 65 (2) 692-694. • Gill JS, Tonelli M, Mix C and Pereira BJG, The Change In Allograft Function In Long-term Kidney Transplant Recipients. Journal Of American Society Of Nephrology. 2003 14: 1636-1642. Landsberg, Dr. David N • Henderson AJZ, Landolt MA, McDonald MF, Landsberg DN, Barrable WM, Soos JG, Gourlay W, Allison CJ. The living anonymous kidney donor: Lunatic or saint? American Journal of Transplantation, Volume 3, Issue 2, Feb 2003 Wong, Dr. Norman L • Wong NLM, Tsui JKC. Angiotensin II up regulates the expression of vasopressin V2 mRNA in the inner medullary collecting duct of the rat. Metabolism 52:290-295, 2003.
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• Wong NLM, Sonntag M, Tsui JKC. Attentuation of renal vasopressin V2 receptor upregulation by bosentan an ETA/ETB receptor antagonist. Metabolism 52:1141-1146, 2003.
Neurology
Devonshire, Dr. Virginia A • Devonshire V, Duquette P, Dwosh E, Guimond C. The immune system and hormones: review and relevance to pregnancy and contraception in women with MS. Int MS J. 2003 Jun; 10(2): 44-50 Review • Devonshire V, Sayao AL, McDonnell G, Oger J. Benign Multiple Sclerosis: an assessment of disability and disease progression in patients with this diagnosis. Multiple Sclerosis 2003; (9S), p135 • Devonshire V, Kim D, Lee C et al. Prevalence of rheumatoid arthritis and other arthropathies in patients with multiple sclerosis: patient survey data from UBC MS Database. Multiple Sclerosis 2003; (9S), 39 • Devonshire V, Kim D, Lee C et al. The prevalence of psoriasis in patients with multiple sclerosis: survey observations from UBC MS Database. Multiple Sclerosis 2003; (9S), p185 Doudet, Dr. Doris J • Watts RL, Raiser CD, Stover NP, Cornfeldt ML, Schwiekert AW, Allen RC, Subramanian T, Doudet DJ, Honey C, Bakay RAE. "Human retinal pigment epithelial cells attached to gelatin microcarriers: a promising new cell therapy for Parkinson's Disease" J. Neural Trans. 65:1-13, 2003 • Doudet DJ, Jivan S, Holden JE. "In vivo measurement of receptor density and affinity: comparison of the routine sequential method with a non sequential method of studies of dopamine D2 receptors with [11C]raclopride" J. Cereb. Blood Flow Metab. 23:280-284, 2003 • McGeer PL, Schwab C, Parent A, Doudet DJ. "Presence of reactive microglia in monkey substantia nigra years after MPTP adminstration." Ann. Neurol. 54:599-604 (2003) • Doudet DJ, Holden JE. "[11C]raclopride PET studies of dopamine release by amphetamine: dependence of presynaptic integrity" Biol. Psychiat. 54:1193-1199 (2003). Feldman, Dr. Howard H • Feldman H. Treating Alzheimer's Disease with Cholinesterase Inhibitors: What have we learned so far? International Psychogeriatrics 2002: 14(1): 3-5. • Scapini ES, Scheltens P, Feldman H. Treatment of Alzheimer's disease: Current status and new perspectives. Lancet Neurology, 2003: 2(9): 539-547. • Rockwood K, Davis H, MacKnight C, Vandorpe R, Gauthier S, Guzman A, Montgomery P, Black S, Hogan DB, Kertesz A, Bouchard R, and Feldman H. The Consortium to Investigate Vascular Impairment of Cognition: Background, methods and impact of diagnostic criteria on the study of vascular cognitive impairment. Canadian Journal of Neurological Sciences, 2003:30(3): 237- 243. • Bird T, Knopman D, VanSwieten J, Rosso S, Feldman H, Tanabe H, Graff-Raford N,
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Geschwind D, Verpillat P, Hutton M. Epidemiology and genetics of frontotemporal dementia/Pick's disease. Annals of Neurology 2003:54(S5): S29-31. • Mackenzie IRA and Feldman H. Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases. Acta Neurapathologica, 2003: 105(6):543-8 • Feldman H, Levy AR, Hsiung GY, Peters KR, Rockwood K, Black S, Bouchard RW, Gauthier SG, Guzman DA, Hogan DB, Kertesz A, Donald A. for the ACCORD study Group. A Canadian Cohort Study of Cognitive Impairment and Related Demetias (ACCORD): Study methods and baseline results. Neuroepidemiology, 2003:22:265-274. • Mackenzie IRA and Feldman H. The relationship between extramotor ubiquitin-immonreactive neuronal inclusions and dementia in motor neuron disease. Acta Neuropathologica, 2003: 105(2): 98-102 • Feldman H, Gauthier S, Hecker J, Vellas B, Emir B, Mastey V, Subbiah P. The Donepezil MSAD Study Investigators Group. Efficacy of Donepezil on Maintenace of Activities of Daily Living in Patients with Moderate to Severe Alzheimer's Disease and the Effect on Caregiver Burden. Journal of the American Geriatrics Society, 2003: 51(6): 737-744. Hashimoto, Dr. Stanley A • Murphy CB, Hashimoto SA, Graeb D, Thiessen BA. Clinical exacerbation of MS following radiotherapy: a case report. Arch Neurol 2003, 60(2): 273-275 Kastrukoff, Dr. Lorne F • Kastruoff LF, Lau AS, Wee R, Zecchini D, White R, Paty DW. 'Novel' valleys in natural killer cell function precede clinical relapses of mutiple sclerosis. Journal of Neuroimmunology 145:103-114, 2003 Krieger, Dr. Charles • Hu J, Chernoff K, Pelech S, and Krieger C. Protein kinase and protein phosphatase expression in the CNS of a G93A mSOD over-expressing mouse model of amyotrophic lateral sclerosis. J. Neurochem. 85:422-431 (2003). • Hu JH, Zhang H, Wagey R, Krieger C, Pelech SL. Protein kinase and protein phosphatase activation in amyotrophic lateral sclerosis spinal cord. J. Neurochem. 85:432-442 (2003). • Krieger C, Hu JH, Pelech SL. Aberrant protein kinases and phosphoproteins in amyotrophic lateral sclerosis. Trends Pharm. Sci. 24: 535-541 (2003). Leavitt, Dr. Blair R • Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, Deng Y, Oh R, Bissada N, Hossain SM, Yang YZ, Li XJ, Simpson EM, Gutekunst CA, Leavitt BR, and Hayden MR, (2003) “Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease”, Human Molecular Genetics 12(13):1-13 • Zuccato C, Tartari M, Crotti A, Goffredo D, Valenza M, Conti L, Cataudella T, Leavitt BR, Hayden MR, Timmusk T, Rigamonti D, and Cattaneo E, (2003) “Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes”, Nature Genetics 35(1):1-8 • Wellington CL, Ellerby LM, Leavitt BR, Roy S, Nicholson DW, and Hayden MR, (2003) “Huntingtin proteolysis in Huntington Disease”, Clinical Neuroscience 3(2003):129-139 • Zhang Y, Li M, Drozda M, Ren S, Sanchez RO, Leavitt BR, Cattaneo E, Ferrante RJ, Hayden MR, and Friedlander RM, (2003) “Depletion of Wild-type Huntingtin in Mouse Models of
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• Hu J, Chernoff K, Pelech S, Krieger C. Protein kinase and protein phosphatase expression in the CNS of a G93A mSOD over-expressing mouse model of amyotrophic lateral sclerosis. J Neurochem. 85:422-431 (2003). • Hu JH, Zhang H, Wagey R, Krieger C, Palech SL. Protein kinase and protein phosphatase activation in amyotrophic lateral sclerosis spinal cord. J. Neurochem. 85:432-442 (2003). • Ryu JK, Choi HB, Hatori K, Heisel RL, Pelech SL, McLarnon JG, Kim SU. Adenosine triphosphate induces proliferation of human neural stem cells: Role of calcium and p70 ribosomal protein 26 kinase. J. Neurosci. Res. 72:352-362 (2003). • Koivisto L, Alavian K, Hakkinen L, Pelech SL, McCulloch CA, Larjava H. Glycogen synthase kinase-3 regulates formation of long lamellipodia in human keratinocytes. J. Cell. Sci. 116:3749-3760 (2003). • Tang L, Cao L, Pelech SL, Lui H, Shapiro J. Cytokines and signal transduction pathways mediated by anthralin in alopecia areata-affected Dundee experimental balding rats. J. Investig. Dermatol. Symp. Proc. 8:87-90 (2003). • Pelech SL, Sutter C, and Zhang H. Methods in Molecular Medicine Series: Cancer Cell Signalling Kinetworks protein kinase multiblot analysis. (D Terrian, ed.) vol. 218, 99-111 Humana Press, (2003). • Krieger C, Hu JH, Pelech SL. Aberrant protein kinases and phosphoproteins in amyotrophic lateral sclerosis. Trends Pharm. Sci. 24:535-541 (2003). Robinson, Dr. Gordon • Chapman KM Szczygielski BI, Toth C, Woolfenden A, Robinson G, Snutch TP, Spacey SD. Pseudomigraine with lymphocytic pleocytosis: a calcium channeloplathy? Clinical description of 10 cases and genetic analysis of the familial hemiplegic migraine gene CACNA1A. Headache. 2003 Sep:43(8):892-5. Spacey, Dr. Sian • Chapman KM, Szczygielski BI, Toth C, Woolfenden A, Robinson G, Snutch TP, Spacey SD. Pseudomigraine with lymphocytic pleocytosis: a calcium channelopathy? Clinical description of 10 cases and genetic analysis of the familial hemiplegic migraine gene CACNA1A. Headache. 2003 Sep;43(8):892-5. • Keogh CF, Andrews GT, Spacey SD, Forkheim KE, Grab DA. Neuroimaging features of heroin inhalation toxicity: "chasing the dragon". AJR Am J Roentgenol. 2003 Mar; 180(3):847-50. Stoessl, Dr. A J • Van Kampen JM, Stoessl AJ. Effects of oligonucleotide antisense to D3 receptor mRNA in a rodent model of behavioural sensitization to levodopa. Neuroscience 2003; 116: 307-314. • de la Fuente-Fernandez R, Lim AS, Sossi V, Adam MJ, Ruth TJ, Calne DB, Stoessl AJ, Lee CS. Age and severity of nigrostriatal damage at onset of Parkinson's disease. Synapse 2003; 47: 152- 8. • Huang Z, de la Fuente-Fernandez R, Stoessl AJ. Etiology of Parkinson's Disease. Can. J. Neurol. Sci. 2003; 30 (Suppl 1): S10-18. • de la Fuente-Fernandez R, Furtado S, Guttman M, Furukawa Y, Lee CS, Calne DB, Ruth TJ, Stoessl AJ. VMAT2 binding is elevated in dopa-responsive dystonia: Visualizing empty vesicles by PET. Synapse 2003; 49: 20-28. • McCormick SE, Stoessl AJ. Central administration of the Neurotensin receptor antagonist
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SR48692 attenuates vacuous chewing movements in a rodent model of Tardive Dyskinesia. Neuroscience 2003; 119: 547-555. • Sossi V, Holden JE, De La Fuente-Fernandez R, Ruth TJ, Stoessl AJ (2003). Effect of Dopamine Loss and the Metabolite 3-O-Methyl-[18F]Fluoro-dopa on the Relation Between the 18F-Fluorodopa Tissue Input Uptake Rate Constant Kocc and the [18F]Fluorodopa Plasma Input Uptake Rate Constant Ki. J Cereb Blood Flow Metab. 23:301-9. • Stoessl AJ (2003). Agonizing over dopaminergic replacement therapy -- lessons from animal models of Parkinson’s disease. Experimental Neurology 183: 1-3. • Whone AL, Watts RL, Stoessl AJ, Davis M, Reske S, Nahmias C, Lang AE, Rascol O, Ribeiro MJ, Remy P, Poewe WH, Hauser RA, Brooks DJ for the REAL-PET Study Group (2003). Slower progression of PD with ropinirole versus L-dopa: the REAL-PET study. Annals of Neurology 54: 93-101. • Kumar A, Mann S, Sossi V, Ruth TJ, Stoessl AJ, Schulzer M, Lee CS (2003). [11C]DTBZ correlates of levodopa responses in asymmetric Parkinson’s disease. Brain 126: 2648-2655. • Olanow CW, Goetz CG, Kordower JH, Stoessl AJ, Sossi V, Brin MF, Shannon KM, Nauert GM, Perl DP, Godbold J, Freeman TB (2003). A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann. Neurol. 54:403-414. • Brooks DJ, Frey KA, Marek KL, Oakes D, Paty D, Prentice R, Shults CW, Stoessl AJ (2003). Assessment of Neuroimaging Techniques as Biomarkers of the Progression of Parkinson's Disease. Experimental Neurology 184 (Suppl 1): S68-79. • Inkster LM, Eng JJ, MacIntyre DL, Stoessl AJ. Leg muscle strength is reduced in PD and relates to the ablity to rise from a chair. Movement Disorders 18(2):157-62, 2003. Thiessen, Dr. Brian A • Murphy CB, Hashimoto SA, Graeb D, Thiessen BA. Clinical exacerbation of MS following radiotherapy: a case report. Arch Neurol 2003, 60(2):273-275. • Gill S, Murray N, Dalmau J, Thiessen B. Paraneoplastic sensory neuronopathy and spontaneous regression of small cell lung cancer. Can J Neurol Sci 2003; 30:269-271. • Thiessen B, Maguire JA, McNeil K, Huntsman D, Martin MA, Horsman D. Loss of heterozygosity for loci on chromosome arms 1p and 10q in oligodendroglial tumors: relationship to outcome and chemosensitivity. J Neuro-Oncol 2003, 64:271-278. Traboulsee, Dr. Anthony • Traboulsee A, J Dehmeshki, KR Peters, CM Griffin, PA Brex, N Silver, O Ciccarrelli, DT Chard, GJ Barker, AJ Thompson and DH Miller. Disability in multiple sclerosis is related to normal appearing brain tissue MTR histogram abnormalities. Multiple Sclerosis 2003, 9:566-573. Tsui, Dr. Joseph K • Lai BCK, Schulzer M, Marion S, Teschke K, Tsui JKC. The prevalence of Parkinson's disease in British Columbia, Canada, estimated by using drug tracer methodology. Parkinsonism and Related Disorders. 2003; 9: 233-238. Wang, Dr. Yu Tian • Man HY, QH Wang, WY Lu, G Ahmadian, S D'Souza, L Liu W. Ju, LE Becker, MP Wymann, JF MacDonald and YT Wang, Selective activation of AMPA receptor-associated PI3-Kinase is required for LTP induction, Neuron, 38:915-928,2003. • Wang J, Liu S, Haditsch U, Tu W, Cochrane K, Ahmadian G, Tran L, Paw J, Wang YT,
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Mansuy I, Salter MM, Lu Y. Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapses. J. Neurosci. 2003; 23: 826-836. • Wang QH, Liu LD, Pei L, Ju W, Ahmadian G, Lu J, Wang YS, Liu L and Wang YT. Control of synaptic strength, a novel function of Akt, Neuron, 38:915-928, 2003. • Man HY, QH Wang, WY Lu, G Ahmadian, S D'Souza, L Liu, W Ju, LE Becker, MP Wymann, JF MacDonald, YT Wang. Activation of P13-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons, Neuron, 38:611-624, 2003. • Nong Y, YQ Huang, W Ju, LV Kalia, G Ahmadian, YT Wang*, MW Salter*(*equal corresponding authors). Glycine binding primes NMDA receptor internalization, Nature, 422:302-307, 2003. • Metzler M, B Li, L Gan, J Georgiou, CA Gutekunst, Y Wang, E Torre, RS Devon, R Oh, V Legendre-Guillemin, M Rich, C Alvarez, M Gertsenstein, PS McPherson, A Nagy, YT Wang, JC Roder, LA Raymond, and MR Hayden. Disruption of the endocytic protein HIP 1 results in neurological deficits and decreased AMPA receptor trafficking, EMBO J. 22:3254-3266, 2003. Woolfenden, Dr. Andrew R • Chapman KM, Szczygielski BI, Toth C, Woolfenden AR, Robinson G, Snutch TP,Spacey SD. Pseudomigraine with lymphocytic pleocytosis: a calcium channelopathy? Clinical description of 10 cases and genetic analysis of the familial hemiplegic migraine gene CACNA1A. Headache. 2003 Sep; 43(8):892-5. • Vados V, Zubov M, Shuaib A, Woolfenden AR, Norris J. Cervical Arterial Dissection: Time for a Therapeutic Trial? Stroke 2003; 34:2856-60. • Heran NS, Heran, MS, Woolfenden AR. A corticosteroid-responsive aneurysmal lenticulostriate vasculopathy. Neurology 2003; 61:1624-5.
Physical & Rehabilitation Medicine
Dawson, Dr. Andrew S • Eng JJ, Chu KS, Kim CM, Dawson AS, Carswell A, Hepburn KE (2003). A community-based group exercise program for persons with chronic stroke. Medicine and Science in Sports and Exercise, 35, 1271-1278. PMID: 12900678
Respiratory Medicine
Bai, Dr. Tony R • Bai TR. Do written action plans improve asthma control? The evidence is not conclusive. Can Resp J. 2003; 10:155-156. • Kuyper, L, Lambert R, Hogg JC, Pare PD, Bai TR. Characterisation of airway plugging in fatal asthma. Am J Med 2003: 115:6-11 [Subject of editorial in same issue] • Ensom ME, Chong G, Zhou D, Beaudin B, Shalansky S and Bai TR. Double blind, Randomized, Placebo-Controlled, crossover Study of Estradiol in premenstrual asthma. Ann Pharmacotherapy 2003; 23 (5):561-71
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• Ensom ME, Chong G, Beaudin B, and Bai TR Estradiol in Severe Asthma with Premenstrual Worsening. Ann Pharmacotherapy 2003; 37:1610-3 • E Danyi Zhou, Xueyan Zheng, Lu Wang, Gerald Stelmack, Andrew J. Halayko, Delbert Dorscheid, and Bai TR. Expression and Effects of Cardiotrophin-1 (CT-1) in Human Airway Smooth Muscle Cells. British J Pharmacol 2003: 140:1584-1591 • Davidson W and Bai TR. Asthma: clearing the way. Can J Diagnosis 2003 November, pp 91-95
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Khalil, Dr. Nasreen • Chen G, Khalil N. GM-CSF increases airway smooth muscle cell connective tissue expression by inducing TGF-beta receptors. 2003;284:L548-L556 • Xu YD, Hua J, Mui A, O'Connor R, Grotendorst N, Khalil N. Release of biologically active
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TGF-beta1 by alveolar epithelial cells results in pulmonary fibrosis. Am J Physiol.: Lung Cell Mol. Physiol. 2003, 285:L527-L539 • Editorial on the article by Dr. Olman, M. And Matthay, M. Transforming growth factor-B induces fibrosis in immune cell-depleted lungs. Am J Physiol.: Lung Cell. Mol. Physiol. 2003, 285:522-L526 Lam, Dr. Stephen C • Sun XR, Zheng Y, MacAulay C, Lam S, Doudkine A, Palcic B. In Vitro Model for Studying Malignancy-Associated Changes. Analytical Cellular Pathology 2003;25(2):95-102 • Huang Z, McWilliams A, Lam S, English J, McLean DI, Lui H, Zeng H. Effect of formalin fixation on the near-infrared Raman spectroscopy of normal and cancerous human bronchial tissues. Int J Oncol 2003;23(3):649-656 • Lam S, Xu XC, Parker-Klein H, leRiche JC, MacAulay C, Guillaud M, Coldman A, Gazdar A, Lotan R. Surrogate endpoint biomarker analysis in a retinol chemoprevention trial in current and former smokers with bronchial dysplasia. Int J Oncol 2003;23:1607-1613 • Zochbauer-Muller S, Lam S, Toyooka S, Virmani AK, Toyooka KO, Seidl S, Minna JD, Gazdar AF. Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers. Int J Cancer 2003; 107:612-616 • McWilliams A, Mayo J, MacDonald S, leRiche J, Palcic B, Szabo E, Lam S. Lung Cancer Screening: A Different Paradigm. Am J Respir Crit Care Med 2003;168:1167-1178 • Huang Z, McWilliams A, Lam S, McLean DI, Lui H, Zeng H. Near-infrared Raman Spectroscopy for Optical Diagnosis of Lung Cancers. Int J Cancer 2003;107(6):1047-1052 • Tsao AS, McDonnell T, Lam S, Putnam JB, Bekel N, Hong WK, Kurie JM. Increased phospho-AKT (Ser473) expression in bronchial dysplasia: Implications for lung cancer prevention studies. Cancer Epidemiol Biomarkers Prev 2003;12:660-664 Levy, Dr. Robert D • Cook RC, Fradet G, Muller NL, Worsely DP, Ostrow D, Levy RD. Evaluation of non-invasive investigation for the early detection of chronic airways dysfunctional following lung transplantation. Can Respir J. 2003;10(2):76-83 • Ensom MHH, Partovi N, Decarie D, Ignaszewski AP, Fradet GJ, Levy RD. Mycophenolate pharmacokinetics in the early period following lung or heart transplantation. Ann Pharmacother 2003; 37:1761-1767 Pare, Dr. Peter D • He JQ, Ruan J, Chan-Yeung M, Becker AB, Dimich-Ward H, Paré PD, Sandford AJ. Polymorphisms of the GM-CSF Genes and the Development of Atopic Diseases in At-Risk Children. Chest. 123(3 Suppl):438S, 2003 • Wang L, McParland BE, Paré PD. The functional consequences of structural changes in the airways: implications for airway hyperresponsiveness in asthma. Chest. 123(3 Suppl):356S-62S, 2003 • Naghshin J, Wang L, Paré PD, Seow CY. Adaptation to chronic length change in explanted airway smooth muscle. J Appl Physiol. 2003 Mar 7 [epub ahead of print] • Moffatt MF, Faux JA, Lester S, Paré PD, McCluskey J, Spargo R, James A, Musk AW, Cookson WOCM. Atopy, respiratory function and HLA-DR in aboriginal Australians. Human Molecular Genetics, 12(6):625-630, 2003 • Kuo KH, Herrera AM, Wang L, Paré PD, Ford LE, Stephens NL, Seow CY. Structure-function
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correlation in airway smooth muscle adapted to different lengths. Am J Physiol Cell Physiol.; 285(2) Aug 2003 • McParland BE, Macklem PT, Paré PD, Airway wall remodeling: friend or foe? J Appl Physiol. 2003 Jul;95(1):426-34. PMID: 12794101 [PubMed - in process] • Kuyper LM, Paré PD, Hogg JC, Lambert RK, Ionescu D, Woods R, Bai TR. Characterization of airway plugging in fatal asthma. Am J Med. 2003 Jul; 115(1):6-11 PMID: 12867228 • Joos L, Weir TD, Connett JE, Anthonisen NR, Woods R, Paré PD, Sandford AJ. Polymorphisms in the beta(2) adrenergic receptor and bronchodilator response, bronchial hyperresponsiveness, and rate of decline in lung function in smokers. Thorax 58(8):703-707, August 2003. • Kasuga I, Paré PD, Ruan J, Connett JE, Anthonisen NR, Sandford AJ. Lack of association of group specific component haplotypes with lung function in smokers. Thorax.;58(9):790-793, September 2003 • Wang Lu, Paré PD. Deep inspiration and airway smooth muscle adaptation to length change. Respiratory Physiology & Neurobiology, 137: 169-178, 2003 Road, Dr. Jeremy • O'Donnell DE, Hernandez P, Aaron S, Road J, et al. Canadian Thoracic Society COPD Guidelines Summary of Highlights for Family Doctors. Can Resp J 10:183-185, 2003 • Robinson PJ, Schellenberg RR, Wakai Y, Road J, Pare PD. Canine trachealis muscle shortening and cartilage mechanics. J Appl Physiol, October 31, 2003 (E. pub ahead of print) Sandford, Dr. Andrew J • He JQ, Connett JE, Anthonisen NR, Sandford AJ. Polymorphisms in the IL13, IL3RA1 and IL4RA genes and rate of decline in lung function in smokers. Am J Respir Cell Mol Biol. 28: 379-385 • He JQ, Chan-Yeung M, Becker AB, Dimich-Ward H, Ferguson AC, Manfreda J, Watson WTA, Sandford AJ. Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children. Genes Immun. 2003; 4:385-389 • Frangolias DD, Ruan J, Wilcox PJ, Davidson GF, Wong LTK, Berthiaume Y, Hennessey R, Freitag A, Pedder L, Corey M, Sweezy N, Zielenski J, Tullis E, Sandford AJ. Alpah-1 antitrypsin deficiency alleles in cystic fibrosis lung disease. Am. J. Respir. Cell Mol. Biol. 2003; 29:390-396. • Joos L, Weir TD, Connett JE, Anthonisen NR, Woods R, Pare PD, Sandford AJ. Polymorphisms in the b2 adrenergic receptor and bronchodilator rsponse, bronchial hyperresponsiveness and rate of decline of lung function in smokers. Thorax. 2003; 58: 703-707 • Kasuga I, Pare PD, Ruan J, Connett JE, Anthonisen NR, Sandford AJ. Lack of association of group-specific component haplotypes with lung function in smokers. Thorax. 2003; 58: 790-793 Ward, Dr. Helen • He JQ, Chan-Yeung M, Becker AB, Dimich-Ward H, Ferguson AC, Manfreda J, Watson WTA, Sandford AJ. Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children. Genes and Immunity 2003; 4:385-9. Yeung, Dr. Moira M • Chan-Yeung M, Malo JL, Tarlo S. Proceedings of the First Jack Pepys' Workshop on Occupational Asthma. Am J Respir Crit Care Med 2003;167:450-71 • El Sony Asma, Beyers N, Enarson D, Chan-Yeung M. Tuberculosis in women. Eur Respir J Monograph 25 - 2003;8:152-166
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• Dimich-Ward J, Wymer M, Kennedy S, Rousseau R, Abboud R, Chan-Yeung M. Evaluation of the respiratory health of radiographers. Am J Ind Med 2003;43:132-141 • Chan-Yeung M, Dimich-Ward H. Respiratory effects of exposure to environmental tobacco smoke. Respirology; 2003;8:131-139 • Chan-Yeung M, Koo L, Tsang KW, Ho L, Chow WS, Chiu SW, Ip MS, Lam WK. Risk factors associated with lung cancer in Hong Kong. Lung Cancer 2003; 40:131-40 • Tam CM, Leung CC, Noertjojo K, Chan SL, Chan-Yeung M. Tuberculosis in Hong Kong--patient characteristics and treatment outcome. HK Med J 2003;9:83-90 • He JQ, Chan-Yeung M, Becker AB, Dimich-Ward H, Ferguson A, Manfreda J, Watson W, Pare P, Sandford A. Genetic variants of the IL13 and IL4 and the development of atopy and atopic diseases during the first two years of life in at risk children. Genetics and Immunity. 2003;4:385-389 • Beyers N, Chan-Yeung M. From Africa to Asia. Int J Tuberc Lung Dis 2003; 1:1-2 • He JQ, Ruan J, Chan-Yeung M, Becker AB, Dimich-Ward H, Pare PD, Sandford AJ. Polymorphisms of the GM-CSF genes and the development of atopic diseases in at-risk children. Chest 2003;123 (3 supple):438S • Tsang KW, Ho PL, Ooi C, Yee WK, Wang T, Chan-Yeung M, Lam WK, Seto WH, Yam LY, Cheung TM, Wong PC, Lam B, Ip MS, Chan J, Yuen KY, Lai KN. A cluster of cases of severe acute respiratory syndrome in Hong Kong. N Engl J Med 2003; March 29th 2003 Online. • Chan-Yeung M, Yu WC. Short report - Severe Acute Respiratory Syndrome in Hong Kong. Br Med J 2003; 326:850-2 • Chan-Yeung M. Asthma - a disease of the rich and the poor. Int J Tuberc Lung Dis 2003; 5:409 • Chan-Yeung M. Severe acute respiratory syndrome (SARS) - a lesson in infectious disease. Int J Tuberc Lung Dis 2003;5:407-8 • Chan-Yeung M. War against virus - who is winning. Int J Tuberc Lung Dis 2003; 7:505-6 • Chan-Yeung M. Tam CM, Leung CC, Wong H, Yew WW, Lam CW, Kam KM. A prospective population-based molecular and conventional epidemiological study of tuberculosis in Hong Kong. J Clin Microbiol. 2003; 41:2706-8 • Chan-Yeung M. Seto WH, Sung JJY, Tsang KW, Lai ST, Yee WKS, Yam L, Ip M, Lam WK, Lai KN. Nosocromial infection by coronalvirus associated with severe acute respiratory syndrome (SARS). BMJ 2003; 326:1393 • Chan-Yeung M, Noertjojo K, Leung CC, Chan SL, Tam CM. Prevalence and predictors of default from tuberculosis treatment in Hong Kong. HKMJ 2003; 9:263-8 • Ho JC, Ooi GC, Mok TY, Chan JW, Hung I, Lam B, Wong PC, Li PC, Ho PL, Lam WK, Ng CK, Ip MS, Lai KN, Chan-Yeung M, Tsang KW. High dose pulse versus non-pulse corticosteroid regimens in severe acute respiratory syndrome. Am J Respir Crit Care Med. 2003 Aug 28 [Epub ahead of print] • Ooi C, Tsang KWT, Cheung YF, Khong PL, Ho IWT, Ip MSM, Tam CM, Ngan H, Lam WK, Chan FL, Chan-Yeung M. Qualitative and quantitative CT evaluation in 76 silica-exposed men: a clinical radiological correlative study. Radiology 2003; 228:816-25 • Ho A, Sung JJY, Chan-Yeung M. An Outbreak of Severe Acute Resipiratory Syndrome (SARS) among hospital workers in a Community Hospital in Hong Kong. Ann Int Med 2003; 139:564-7. • Chan-Yeung M. R-H Ru. Severe acute respiratory syndrome - epidemiology. Respirolgy 2003; 8 suppl:S9-S14 • Chan-Yeung Ooi CG, Hui DS, Ho PL, Tsang KW. State of the Art. Severe acute respiratory syndrome. Int J Tuberc Lung Dis 2003; 12:1117-30
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Rheumatology
Ensworth, Dr. Stephanie G • Al-Herz A, Ensworth S, Shojania K, Esdaile, JM. Cardiovascular Risk Factor Screening in Systemic Lupus Erythematosus. J. Rheumatology 30(3):493-6, 2003 • Ensworth S. Anti-Rheumatic Medications during Pregnancy and Lactation, Part 2 The Journal of the Canadian Rheumatology Assoc 13(1):4-16, 2003 • Edworthy SM, Dobkin PL, Clarke AE, Costa DD, Dritsa M, Fortin PR, Barr S, Ensworth S, Esdaile JM, Beaulieu A, Zummer M, Senecal JL, Goulet JR, Choquette D, Rich E, Smith D, Cividino A, Gladman D, Devins GM. Group psychotherapy reduces illness intrusiveness in systemic lupus erythematosus. J. Rheumatology 30(5):1011-6, 2003 Esdaile, Dr. John M • Cibere J, Esdaile JM. Randomized, double-blind, placebo-controlled trial of topical tripterygium wilfordii in rheumatoid arthritis: A reanalysis using logistic regression analysis. J Rheumatol. 2003;30:465-7 • Al-Herz A, Ensworth E, Shojania K, Esdaile JM. Cardiovascular Risk Factor Screening in SLE. J Rheumatol 2003;30:493-6 • Edworthy SM, Dobkin PL, Clark AE, Da Costa D, Drista M, Fortin PR, Barr S, Ensworth S, Esdaile JM, Beaulieu A, Zummer M, Senecal J-L, Goulet J-R, Choquette D, Rich E, Smith D, Cividino A, Gladman D, Devins GJ. Group psychotherapy reduces illness intrusiveness in systemic lupus erythematosus. J Rheumatol 2003;30:1011-6. • Badii M. Shin S, Torreggiani WC, Jankovic B, Gustafson P, Munk PL, Esdaile JM. Pelvic bone asymmetry in 323 study participants receiving abdominal CT scans. Spine 2003:28:1335-9. Shojania, Dr. Kamran • Nahar I, Shojania K, Marra CA, Alamgir AH, Anis AH. Infliximab: A qualitative review of its role in the treatment of rheumatoid arthritis and Crohn's disease. Annals Pharmacother 2003;37(9): 1256-65 • Al-Herz A, Ensworth S, Shojania K, Esdaile JM. Cardiovascular risk factor screening in systemic lupus erythematosus. J Rheumatol 2003;30:493-7.
UBC Department of Medicine Page 179 Annual Report 2003