September 5, 2017 u vol. 114 u no. 36

From the Cover

E7499 Coevolutionary adaptations in plants and insects E7405 and DNA replication E7425 Social networks and community health 9581 City infrastructure and stream health 9653 Human autism and bee sociality

Contents

Cover image: Pictured is a Hapigia sp. THIS WEEK IN PNAS caterpillar, a herbivore associated with 9487 In This Issue the Amazonian tree genus Inga. María- José Endara et al. found that closely related Inga species have highly NEWS FEATURE—An in-depth look at trending science issues divergent antiherbivore defenses. 9490 Singing in the brain Further, closely related lepidopteran Helen H. Shen herbivores prefer grazing on Inga species with similar defenses rather than PROFILE on closely related plants. According to the authors, plants may evolve rapidly 9494 Profile of Margaret J. McFall-Ngai based on herbivore selection. However, Jennifer Viegas the evolutionary trajectory of herbivores See Inaugural Article on page 9510 may be slow and based on the ’ herbivores own traits at the time they COMMENTARIES encounter a new host. See the article by Endara et al. on pages E7499–E7505. 9497 Designed metalloenediyne warheads damage DNA and outpace Image courtesy of María-José Endara. DNA polymerase Martin L. Kirk See companion article on page E7405 9500 Putting the network in network interventions Thomas W. Valente See companion article on page E7425 9502 Shared sociogenetic basis of honey bee behavior and human risk for autism Bernard J. Crespi See companion article on page 9653

PNAS PLUS 9505 Significance Statements Brief statements written by the authors about the significance of their papers.

INAUGURAL ARTICLE 9510 Motile cilia create fluid-mechanical microhabitats for the active recruitment of the host microbiome Janna C. Nawroth, Hanliang Guo, Eric Koch, Elizabeth A. C. Heath-Heckman, John C. Hermanson, Edward G. Ruby, John O. Dabiri, Eva Kanso, and Margaret McFall-Ngai See Profile on page 9494

Free online through the PNAS open access option. PNAS u September 5, 2017 u vol. 114 u no. 36 u iii–vii Downloaded by guest on September 30, 2021 ENVIRONMENTAL SCIENCES PHYSICAL SCIENCES 9552 Southern Annular Mode drives multicentury wildfire APPLIED MATHEMATICS activity in southern South America 9517 Locally embedded presages of global network bursts Andre´s Holz, Juan Paritsis, Ignacio A. Mundo, Thomas T. Satohiro Tajima, Takeshi Mita, Douglas J. Bakkum, Hirokazu Veblen, Thomas Kitzberger, Grant J. Williamson, Ezequiel Takahashi, and Taro Toyoizumi Ara´oz, Carlos Bustos-Schindler, Mauro E. Gonza´lez, H. Ricardo Grau, and Juan M. Quezada

APPLIED PHYSICAL SCIENCES 9523 Redox properties of birnessite from a PHYSICS defect perspective 9558 Tracking the insulator-to-metal phase transition in VO2 Haowei Peng, Ian G. McKendry, Ran Ding, Akila C. Thenuwara, with few-femtosecond extreme UV transient Qing Kang, Samantha L. Shumlas, Daniel R. Strongin, Michael J. absorption spectroscopy Zdilla, and John P. Perdew Marieke F. Jager, Christian Ott, Peter M. Kraus, Christopher J. 9599 Simple phalanx pattern leads to energy saving in Kaplan, Winston Pouse, Robert E. Marvel, Richard F. Haglund, cohesive fish schooling Daniel M. Neumark, and Stephen R. Leone Intesaaf Ashraf, Hanae´Bradshaw, Thanh-Tung Ha, Jose´Halloy, 9564 Hydrodynamic and entropic effects on colloidal Ramiro Godoy-Diana, and Benjamin Thiria diffusion in corrugated channels Xiang Yang, Chang Liu, Yunyun Li, Fabio Marchesoni, Peter BIOPHYSICS AND COMPUTATIONAL BIOLOGY Ha¨nggi, and H. P. Zhang E7460 Foldamer hypothesis for the growth and sequence 9570 Band gap formation and Anderson localization differentiation of prebiotic polymers in disordered photonic materials with Elizaveta Guseva, Ronald N. Zuckermann, and Ken A. Dill structural correlations 9510 Motile cilia create fluid-mechanical microhabitats for Luis S. Froufe-Pe´rez, Michael Engel, Juan Jose´Sa´enz, and Frank Scheffold the active recruitment of the host microbiome Janna C. Nawroth, Hanliang Guo, Eric Koch, Elizabeth A. C. Heath-Heckman, John C. Hermanson, Edward G. Ruby, John O. SUSTAINABILITY SCIENCE Dabiri, Eva Kanso, and Margaret McFall-Ngai 9575 Soil carbon debt of 12,000 years of human 9529 Size- and speed-dependent mechanical behavior in land use living mammalian cytoplasm Jonathan Sanderman, Tomislav Hengl, and Gregory J. Fiske Jiliang Hu, Somaye Jafari, Yulong Han, Alan J. Grodzinsky, 9581 US cities can manage national hydrology and Shengqiang Cai, and Ming Guo biodiversity using local infrastructure policy 9535 Parity-dependent hairpin configurations of repetitive Ryan A. McManamay, Sujithkumar Surendran Nair, DNA sequence promote slippage associated with Christopher R. DeRolph, Benjamin L. Ruddell, April M. Morton, DNA expansion Robert N. Stewart, Matthew J. Troia, Liem Tran, Hyun Kim, and Budhendra L. Bhaduri Tze-Yun Huang, Chung-ke Chang, Ya-Fen Kao, Chih-Hao Chin, Cheng-Wei Ni, Hao-Yi Hsu, Nien-Jen Hu, Li-Ching Hsieh, 9647 Emerging role of wetland methane emissions in Shan-Ho Chou, I-Ren Lee, and Ming-Hon Hou driving 21st century climate change 9605 Topological impact of noncanonical DNA structures on Zhen Zhang, Niklaus E. Zimmermann, Andrea Stenke, Klenow fragment of DNA polymerase Xin Li, Elke L. Hodson, Gaofeng Zhu, Chunlin Huang, and Benjamin Poulter Shuntaro Takahashi, John A. Brazier, and Naoki Sugimoto 9617 Prion β2–α2 loop conformational landscape Enrico Caldarulo, Alessandro Barducci, Kurt Wu¨thrich, SOCIAL SCIENCES and Michele Parrinello PSYCHOLOGICAL AND COGNITIVE SCIENCES E7602 Evidence for cue-independent spatial representation in E7405 Metal-mediated diradical tuning for DNA replication the human auditory cortex during active listening arrest via template strand scission Nathan C. Higgins, Susan A. McLaughlin, Teemu Rinne, Meghan R. Porter, Sarah E. Lindahl, Anne Lietzke, Erin M. and G. Christopher Stecker Metzger, Quan Wang, Erik Henck, Chun-Hsing Chen, Hengyao 9587 Individuals with greater science literacy and education Niu, and Jeffrey M. Zaleski have more polarized beliefs on controversial See Commentary on page 9497 science topics 9541 In situ nano- to microscopic imaging and growth Caitlin Drummond and Baruch Fischhoff mechanism of electrochemical dissolution (e.g., corrosion) of a confined metal surface C. Merola, H.-W. Cheng, K. Schwenzfeier, K. Kristiansen, SOCIAL SCIENCES Y.-J. Chen, H. A. Dobbs, J. N. Israelachvili, and M. Valtiner E7425 Social network fragmentation and community health Goylette F. Chami, Sebastian E. Ahnert, Narcis B. Kabatereine, EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES and Edridah M. Tukahebwa E7415 On transient climate change at the Cretaceous− See Commentary on page 9500 Paleogene boundary due to atmospheric soot injections E7432 Prospect theory and the decision to move or stay Charles G. Bardeen, Rolando R. Garcia, Owen B. Toon, William A. V. Clark and William Lisowski and Andrew J. Conley 9593 Exposure to rising inequality shapes Americans’ 9547 Late-stage magmatic outgassing from a opportunity beliefs and policy support volatile-depleted Moon Leslie McCall, Derek Burk, Marie Laperrie`re, James M. D. Day, Fre´de´ric Moynier, and Charles K. Shearer and Jennifer A. Richeson

iv u www.pnas.org Contents Downloaded by guest on September 30, 2021 SUSTAINABILITY SCIENCE CELL BIOLOGY 9587 Individuals with greater science literacy and education E7469 Reversal of hyperactive Wnt signaling-dependent have more polarized beliefs on controversial adipocyte defects by boronic acids science topics Tianyi Zhang, Fu-Ning Hsu, Xiao-Jun Xie, Xiao Li, Mengmeng Caitlin Drummond and Baruch Fischhoff Liu, Xinsheng Gao, Xun Pei, Yang Liao, Wei Du, and Jun-Yuan Ji E7479 Involvement of posttranscriptional regulation of Clock in the emergence of circadian clock oscillation BIOLOGICAL SCIENCES during mouse development APPLIED BIOLOGICAL SCIENCES Yasuhiro Umemura, Nobuya Koike, Munehiro Ohashi, Yoshiki Tsuchiya, Qing Jun Meng, Yoichi Minami, Masayuki Hara, Moe E7441 Targeted PET imaging strategy to differentiate Hisatomi, and Kazuhiro Yagita malignant from inflamed lymph nodes in 9629 Identification of NRAS isoform 2 overexpression as diffuse large B-cell lymphoma a mechanism facilitating BRAF inhibitor resistance Jun Tang, Darin Salloum, Brandon Carney, Christian Brand, Susanne Kossatz, Ahmad Sadique, Jason S. Lewis, Wolfgang A. in malignant melanoma Weber, Hans-Guido Wendel, and Thomas Reiner Megan C. Duggan, Andrew R. Stiff, Maryam Bainazar, Kelly Regan, Gonzalo N. Olaverria Salavaggione, Sophia Maharry, 9599 Simple phalanx pattern leads to energy saving in James S. Blachly, Madison Krischak, Christopher J. Walker, cohesive fish schooling Nicholas Latchana, Susheela Tridandapani, Albert de la Intesaaf Ashraf, Hanae´Bradshaw, Thanh-Tung Ha, Jose´Halloy, Chapelle, Ann-Kathrin Eisfeld, and William E. Carson III Ramiro Godoy-Diana, and Benjamin Thiria ECOLOGY BIOCHEMISTRY 9635 Targeted habitat restoration can reduce extinction E7405 Metal-mediated diradical tuning for DNA replication rates in fragmented forests arrest via template strand scission William D. Newmark, Clinton N. Jenkins, Stuart L. Pimm, Phoebe B. McNeally, and John M. Halley Meghan R. Porter, Sarah E. Lindahl, Anne Lietzke, Erin M. Metzger, Quan Wang, Erik Henck, Chun-Hsing Chen, Hengyao 9641 Caterpillars lack a resident gut microbiome Niu, and Jeffrey M. Zaleski Tobin J. Hammer, Daniel H. Janzen, Winnie Hallwachs, See Commentary on page 9497 Samuel P. Jaffe, and Noah Fierer E7450 MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis ENVIRONMENTAL SCIENCES Shuzhen Liu, Hua Liu, Andrea Johnston, Sarah Hanna-Addams, E7489 Host-derived viral transporter protein for nitrogen Eduardo Reynoso, Yougui Xiang, and Zhigao Wang uptake in infected marine phytoplankton 9605 Topological impact of noncanonical DNA structures on Adam Monier, Aure´lie Chambouvet, David S. Milner, Victoria Klenow fragment of DNA polymerase Attah, Ramo´n Terrado, Connie Lovejoy, Herve´ Moreau, Shuntaro Takahashi, John A. Brazier, and Naoki Sugimoto Alyson E. Santoro, E´velyne Derelle, and Thomas A. Richards 9611 Cellular cap-binding protein, eIF4E, promotes 9552 Southern Annular Mode drives multicentury wildfire picornavirus genome restructuring activity in southern South America and translation Andre´s Holz, Juan Paritsis, Ignacio A. Mundo, Thomas T. Brian C. Avanzino, Gabriele Fuchs, and Christopher S. Fraser Veblen, Thomas Kitzberger, Grant J. Williamson, Ezequiel Ara´oz, Carlos Bustos-Schindler, Mauro E. Gonza´lez, H. Ricardo Grau, and Juan M. Quezada BIOPHYSICS AND COMPUTATIONAL BIOLOGY 9647 Emerging role of wetland methane emissions in E7460 Foldamer hypothesis for the growth and sequence driving 21st century climate change differentiation of prebiotic polymers Zhen Zhang, Niklaus E. Zimmermann, Andrea Stenke, Elizaveta Guseva, Ronald N. Zuckermann, and Ken A. Dill Xin Li, Elke L. Hodson, Gaofeng Zhu, Chunlin Huang, 9529 Size- and speed-dependent mechanical behavior in and Benjamin Poulter living mammalian cytoplasm Jiliang Hu, Somaye Jafari, Yulong Han, Alan J. Grodzinsky, EVOLUTION Shengqiang Cai, and Ming Guo E7499 Coevolutionary arms race versus host defense chase in 9535 Parity-dependent hairpin configurations of repetitive a tropical herbivore–plant system DNA sequence promote slippage associated with Marı´a-Jose´ Endara, Phyllis D. Coley, Gabrielle Ghabash, DNA expansion James A. Nicholls, Kyle G. Dexter, David A. Donoso, Tze-Yun Huang, Chung-ke Chang, Ya-Fen Kao, Chih-Hao Chin, Graham N. Stone, R. Toby Pennington, and Thomas A. Kursar Cheng-Wei Ni, Hao-Yi Hsu, Nien-Jen Hu, Li-Ching Hsieh, 9653 Deep evolutionary conservation of Shan-Ho Chou, I-Ren Lee, and Ming-Hon Hou autism-related genes 9617 Prion protein β2–α2 loop conformational landscape Hagai Y. Shpigler, Michael C. Saul, Frida Corona, Lindsey Block, Enrico Caldarulo, Alessandro Barducci, Kurt Wu¨thrich, Amy Cash Ahmed, Sihai D. Zhao, and Gene E. Robinson and Michele Parrinello See Commentary on page 9502 9623 Numerous uncharacterized and highly divergent microbes which colonize humans are revealed GENETICS by circulating cell-free DNA E7506 Indoles from commensal bacteria extend healthspan Mark Kowarsky, Joan Camunas-Soler, Michael Kertesz, Iwijn De Robert Sonowal, Alyson Swimm, Anusmita Sahoo, Liping Luo, Vlaminck, Winston Koh, Wenying Pan, Lance Martin, Norma F. Yohei Matsunaga, Ziqi Wu, Jui A. Bhingarde, Elizabeth A. Ejzak, Neff, Jennifer Okamoto, Ronald J. Wong, Sandhya Kharbanda, Ayush Ranawade, Hiroshi Qadota, Domonica N. Powell, Yasser El-Sayed, Yair Blumenfeld, David K. Stevenson, Gary M. Christopher T. Capaldo, Jonathan M. Flacker, Rhienallt M. Shaw, Nathan D. Wolfe, and Stephen R. Quake Jones, Guy M. Benian, and Daniel Kalman

Contents PNAS u September 5, 2017 u vol. 114 u no. 36 u v Downloaded by guest on September 30, 2021 E7516 Vertebrate-like CRYPTOCHROME 2 from monarch 9683 Nasopharyngeal carcinoma super-enhancer–driven regulates circadian transcription via independent ETV6 correlates with prognosis repression of CLOCK and BMAL1 activity Liangru Ke, Hufeng Zhou, Chong Wang, Geng Xiong, Yanqun Ying Zhang, Matthew J. Markert, Shayna C. Groves, Paul E. Xiang, Yihong Ling, Abdelmajid Khabir, George S. Tsao, Yixin Hardin, and Christine Merlin Zeng, Musheng Zeng, Pierre Busson, Elliott Kieff, Xiang Guo, and Bo Zhao E7526 DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation 9689 Capturing LTA4 hydrolase in action: Insights to the and disease chemistry and dynamics of chemotactic Danuta M. Jeziorska, Robert J. S. Murray, Marco De Gobbi, LTB4 synthesis Ricarda Gaentzsch, David Garrick, Helena Ayyub, Taiping Chen, Alena Stsiapanava, Bengt Samuelsson, En Li, Jelena Telenius, Magnus Lynch, Bryony Graham, and Jesper Z. Haeggstro¨m Andrew J. H. Smith, Jonathan N. Lund, Jim R. Hughes, 9695 Local gene therapy durably restores vestibular Douglas R. Higgs, and Cristina Tufarelli function in a mouse model of Usher syndrome type 1G 9659 Sensitized mutagenesis screen in Factor V Leiden mice Alice Emptoz, Vincent Michel, Andrea Lelli, Omar Akil, Jacques identifies thrombosis suppressor loci Boutet de Monvel, Ghizlene Lahlou, Anaı¨s Meyer, Typhaine Randal J. Westrick, Ka¨rt Tomberg, Amy E. Siebert, Guojing Dupont, Sylvie Nouaille, Elody Ey, Filipa Franca de Barros, Zhu, Mary E. Winn, Sarah L. Dobies, Sara L. Manning, Mathieu Beraneck, Didier Dulon, Jean-Pierre Hardelin, Marisa A. Brake, Audrey C. Cleuren, Linzi M. Hobbs, Lena M. Lawrence Lustig, Paul Avan, Christine Petit, Mishack, Alexander J. Johnston, Emilee Kotnik, David R. and Saaid Safieddine Siemieniak, Jishu Xu, Jun Z. Li, Thomas L. Saunders, 9701 Inactivation of CREBBP expands the germinal center and David Ginsburg B cell compartment, down-regulates MHCII 9665 Stalled replication forks generate a distinct mutational expression and promotes DLBCL growth signature in yeast Hind Hashwah, Corina A. Schmid, Sabrina Kasser, Katrin Nicolai B. Larsen, Sascha E. Liberti, Ivan Vogel, Signe W. Bertram, Anna Stelling, Markus G. Manz, and Anne Mu¨ller Jørgensen, Ian D. Hickson, and Hocine W. Mankouri

IMMUNOLOGY AND INFLAMMATION MICROBIOLOGY E7536 Foxp3-independent mechanism by which TGF-β E7564 Structures of phlebovirus glycoprotein Gn and controls peripheral T cell tolerance identification of a neutralizing antibody epitope Soyoung A. Oh, Ming Liu, Briana G. Nixon, Davina Kang, Ahmed Yan Wu, Yaohua Zhu, Feng Gao, Yongjun Jiao, Babayemi O. Toure, Michael Bivona, and Ming O. Li Oladejo, Yan Chai, Yuhai Bi, Shan Lu, Mengqiu Dong, Chang E7545 Cytochrome P450 monooxygenase lipid metabolites Zhang, Guangmei Huang, Gary Wong, Na Li, Yanfang Zhang, Yan Li, Wen-hai Feng, Yi Shi, Mifang Liang, Rongguang Zhang, are significant second messengers in the resolution Jianxun Qi, and George F. Gao of choroidal neovascularization Eiichi Hasegawa, Saori Inafuku, Lama Mulki, Yoko Okunuki, Ryoji E7574 Coupling between D-3-phosphoglycerate dehydrogenase Yanai, Kaylee E. Smith, Clifford B. Kim, Garrett Klokman, and D-2-hydroxyglutarate dehydrogenase drives Diane R. Bielenberg, Narender Puli, John R. Falck, Deeba bacterial L-serine synthesis Husain, Joan W. Miller, Matthew L. Edin, Darryl C. Zeldin, Kin Wen Zhang, Manman Zhang, Chao Gao, Yipeng Zhang, Sing Stephen Lee, Bruce D. Hammock, Wolf-Hagen Schunck, Yongsheng Ge, Shiting Guo, Xiaoting Guo, Zikang and Kip M. Connor Zhou, Qiuyuan Liu, Yingxin Zhang, Cuiqing Ma, Fei Tao, 9671 Protective major histocompatibility complex allele and Ping Xu prevents type 1 diabetes by shaping the intestinal E7583 Paradoxical enhancement of chemoreceptor detection microbiota early in ontogeny sensitivity by a sensory adaptation Michael Silverman, Lindsay Kua, Alessandro Tanca, Mauro Pala, Run-Zhi Lai (赖润智), Xue-Sheng Han, Frederick W. Dahlquist, Antonio Palomba, Ceylan Tanes, Kyle Bittinger, Sergio Uzzau, and John S. Parkinson Christophe Benoist, and Diane Mathis E7592 Genomic diversification of giant enteric symbionts 9677 Distinct PKC-mediated posttranscriptional events set reflects host dietary lifestyles + cytokine production kinetics in CD8 T cells David Kamanda Ngugi, Sou Miyake, Matt Cahill, Manikandan Fiamma Salerno, Nahuel A. Paolini, Regina Stark, Marieke Vinu, Timothy J. Hackmann, Jochen Blom, Matthew D. Tietbohl, von Lindern, and Monika C. Wolkers Michael L. Berumen, and Ulrich Stingl 9510 Motile cilia create fluid-mechanical microhabitats for MEDICAL SCIENCES the active recruitment of the host microbiome E7425 Social network fragmentation and community health Janna C. Nawroth, Hanliang Guo, Eric Koch, Elizabeth A. C. Goylette F. Chami, Sebastian E. Ahnert, Narcis B. Kabatereine, Heath-Heckman, John C. Hermanson, Edward G. Ruby, John O. and Edridah M. Tukahebwa Dabiri, Eva Kanso, and Margaret McFall-Ngai See Commentary on page 9500 E7554 Molecularly targeted drug combinations demonstrate NEUROSCIENCE selective effectiveness for myeloid- and E7602 Evidence for cue-independent spatial representation in lymphoid-derived hematologic malignancies the human auditory cortex during active listening Stephen E. Kurtz, Christopher A. Eide, Andy Kaempf, Vishesh Nathan C. Higgins, Susan A. McLaughlin, Teemu Rinne, Khanna, Samantha L. Savage, Angela Rofelty, Isabel English, and G. Christopher Stecker Hibery Ho, Ravi Pandya, William J. Bolosky, Hoifung Poon, – Michael W. Deininger, Robert Collins, Ronan T. Swords, Justin E7612 Cell-type specific inhibition of the dendritic plateau Watts, Daniel A. Pollyea, Bruno C. Medeiros, Elie Traer, potential in striatal spiny projection neurons Cristina E. Tognon, Motomi Mori, Brian J. Druker, Kai Du, Yu-Wei Wu, Robert Lindroos, Yu Liu, Bala´zs Ro´zsa, and Jeffrey W. Tyner Gergely Katona, Jun B. Ding, and Jeanette Hellgren Kotaleski

vi u www.pnas.org Contents Downloaded by guest on September 30, 2021 E7622 CD146 coordinates brain endothelial cell–pericyte PLANT BIOLOGY communication for blood–brain barrier development E7632 Predicting gene regulatory networks by combining Jianan Chen, Yongting Luo, Hui Hui, Tanxi Cai, Hongxin spatial and temporal gene expression data in Huang, Fuquan Yang, Jing Feng, Jingjing Zhang, Arabidopsis root stem cells and Xiyun Yan Maria Angels de Luis Balaguer, Adam P. Fisher, Natalie M. Clark, 9517 Locally embedded presages of global network bursts Maria Guadalupe Fernandez-Espinosa, Barbara K. Mo¨ller, Dolf Satohiro Tajima, Takeshi Mita, Douglas J. Bakkum, Hirokazu Weijers, Jan U. Lohmann, Cranos Williams, Oscar Lorenzo, Takahashi, and Taro Toyoizumi and Rosangela Sozzani 9707 Hsp90 activator Aha1 drives production of E7641 Auxin minimum triggers the developmental switch pathological tau aggregates from cell division to cell differentiation in the Lindsey B. Shelton, Jeremy D. Baker, Dali Zheng, Leia E. Arabidopsis root Sullivan, Parth K. Solanki, Jack M. Webster, Zheying Riccardo Di Mambro, Micol De Ruvo, Elena Pacifici, Elena Sun, Jonathan J. Sabbagh, Bryce A. Nordhues, John Salvi, Rosangela Sozzani, Philip N. Benfey, Wolfgang Busch, Koren III, Suman Ghosh, Brian S. J. Blagg, Laura J. Blair, Ondrej Novak, Karin Ljung, Luisa Di Paola, Athanasius F. M. and Chad A. Dickey Mare´e, Paolo Costantino, Veroˆnica A. Grieneisen, 9713 Dynamic connectivity modulates local activity in the and Sabrina Sabatini core regions of the default-mode network Wei Tang, Hesheng Liu, Linda Douw, Mark A. Kramer, Uri T. PSYCHOLOGICAL AND COGNITIVE SCIENCES Eden, Matti S. Ha¨ma¨la¨inen, and Steven M. Stufflebeam 9743 Asymmetries in behavioral and neural responses to 9719 Mechanisms of synaptic depression at the hair cell spectral cues demonstrate the generality of ribbon synapse that support auditory nerve function auditory looming bias Juan D. Goutman Robert Baumgartner, Darrin K. Reed, Brigitta To´th, Virginia Best, Piotr Majdak, H. Steven Colburn, and Barbara Shinn-Cunningham

PHARMACOLOGY 9725 Covalent inhibitors for eradication of drug-resistant CORRECTIONS (ONLINE ONLY) HIV-1 reverse transcriptase: From design to protein crystallography AGRICULTURAL SCIENCES Albert H. Chan, Won-Gil Lee, Krasimir A. Spasov, Jose´A. E7650 Overexpression of a pH-sensitive nitrate transporter in Cisneros, Shalley N. Kudalkar, Zaritza O. Petrova, Amanda B. rice increases crop yields Buckingham, Karen S. Anderson, and William L. Jorgensen Xiaorong Fan, Zhong Tang, Yawen Tan, Yong Zhang, Bingbing Luo, Meng Yang, Xingming Lian, Qirong Shen, Anthony John Miller, and Guohua Xu PHYSIOLOGY 9731 Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction CELL BIOLOGY Rigo Cintron-Colon, Manuel Sanchez-Alavez, William Nguyen, E7651 Dual-specificity phosphatase 5 controls the localized Simone Mori, Ruben Gonzalez-Rivera, Tiffany Lien, Tamas inhibition, propagation, and transforming potential Bartfai, Saba Aı¨d, Jean-Christophe Franc¸ois, Martin of ERK signaling Holzenberger, and Bruno Conti Andrew M. Kidger, Linda K. Rushworth, Julia Stellzig, 9737 The 4E-BP growth pathway regulates the effect of Jane Davidson, Christopher J. Bryant, Cassidy Bayley, ambient temperature on Drosophila metabolism Edward Caddye, Tim Rogers, Stephen M. Keyse, and lifespan and Christopher J. Caunt Gil B. Carvalho, Ilaria Drago, Sany Hoxha, Ryuichi Yamada, Olena Mahneva, Kimberley D. Bruce, Alina Soto Obando, Bruno Conti, and William W. Ja ix Subscription Form

Contents PNAS u September 5, 2017 u vol. 114 u no. 36 u vii Downloaded by guest on September 30, 2021