Mouse GRIA2 Blocking Peptide (DAG-P1711) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Mouse GRIA2 blocking peptide (DAG-P1711) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5- methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]

Nature Synthetic

Expression System N/A

Conjugate Unconjugated

Applications BL

Sequence Similarities Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.

Cellular Localization Cell membrane. Endoplasmic reticulum membrane. Cell junction > synapse > postsynaptic cell membrane. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.

Procedure None

Format Liquid

Preservative None

Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

ANTIGEN GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol GRIA2

Synonyms GRIA2; glutamate receptor, ionotropic, AMPA 2; GLUR2; GLURB; GluA2; HBGR2; GluR-K2; glutamate receptor 2; gluR-2; gluR-B; AMPA-selective glutamate receptor 2;

Entrez Gene ID 2891 mRNA Refseq NM_000826.3

Protein Refseq NP_000817.2

UniProt ID I6L997

Chromosome Location 4q32.1

Pathway Activation of AMPA receptors, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; BDNF signaling pathway, organism-specific biosystem; Circadian entrainment, organism-specific biosystem; Circadian e

Function alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; ionotropic glutam

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]