CbnÅ“rResearch VOLUME 52 •¿NUMBER2 •¿CNREA8•¿PP249-000

CONTENTS§

Asterisks # preceding page numbers refer to studies using human-derived material.

314 Complementary DNA Cloning, Messenger RNA Expression, and Induction of a-Class Gluthathione S-Transferases in Mouse Perspectivesin CancerResearch Tissues. Timo M. Buetler and David L. Eaton. !319 Isolation and Characterization of a 1-0-D-Arabinofuranosylcyto- 249 The Origin of Point Mutations in Human Tumor Cells. Bernard S. Strauss. sine-resistant Chinese Hamster Ovary Cell Mutant That Is Also X-Ray Sensitive and Is Noncomplementary with Ataxia 1danni- ectasia Cells. Gloria A. Preston, Helen S. Payne, and R. Julian Preston. ***254 Cigarette Smoking and Cancers of the Renal Pelvis and Ureter. "328 Mechanism of Cross-Resistance to a Camptothecin Analogue Joseph K. McLaughlin, Debra T. Silverman, Ann W. Hsing, (CPT-11) in a Human Ovarian Cancer Cell Line Selected by Ronald K. Ross, Janet B. Schoenberg, Mimi C. Yu, Annette Cisplatin. Shigeki Numi, Kazuhiko Nakagawa, Yoshikazu Stemhagen, Charles F. Lynch, William J. Blot, and Joseph F. Sugimoto, Kazuto Nishio, Yasuhiro Fujiwara, Shiro Yokoyama, Fraumeni, Jr. Yoshiteru Terashima, and Nagahiro Saijo. * 258 Proliferation-linked Regulation of Type II IMP Dehydrogenase :334 Inhibition of DNA Synthesis and Growth in Human Breast Gene in Human Normal Lymphocytes and HL-60 Leukemic Cells. Stromal Cells by Bradykinin: Evidence for Independent Roles of Masami Nagai, Yutaka Natsumeda, and George Weber. BI and B2 Receptors in the Respective Control of Cell Growth and "^262 The Effects of Interleukin 2 and a-Interferon Administration on Phospholipid Hydrolysis. Kirti V. Patel and Michael P. Schrey. Hepatic Drug Metabolism in Mice. SherryS. Ansher, Raj K. Puri, '341 Transforming Growth Factor-«Acts as an Autocrine Growth Walter C. Thompson, and William H. Habig. Factor in Ovarian Carcinoma Cell Lines. Kurt Stromberg, 267 Molecular Dosimetry in Rat Urine of Aflatoxin-.V7-guanineand Theodore J. Collins IV, Alfred W. Gordon, Carolyn L. Jackson, Other Aflatoxin Metabolites by Multiple Monoclonal Antibody and Gibbes R. Johnson. Affinity Chromatography and Immunoaffinity/High Performance -l Locus Is a h367fa Spatial Distribution of Tumor-specific Monoclonal Antibodies in Rare Event in Colorectal Tumors. Joanne Young, Jeffrey Searle, Human Melanoma Xenografts. Ty R. Shockley, Ke Lin, Janice A. Russell Stitz, Alistair Cowen, Michael Ward, and Georgia Nagy, Ronald G. Tompkins, Martin L. Yarmush, and Harold F. Chenevix-Trench. Dvorak. *290 17/J-Hydroxysteroid Dehydrogenase Gene Expression in Human ^377 Predicted and Observed Effects of Antibody Affinity and Antigen Breast Cancer Cells: Regulation of Expression by a Progestin. Density on Monoclonal Antibody Uptake in Solid Tumors. Matti Poutanen, Bruno Moncharmont, and Reijo Vihko. Cynthia Sung, Ty R. Shockley, Paul F. Morrison, Harold F. ***295 Growth Inhibition of Transforming Growth Factor ßonHuman Dvorak, Martin L. Yarmush, and Robert L. Dedrick. Gastric Carcinoma Cells: Receptor and Postreceptor Signaling. "385 In Vitro Apoptosis in the Human Hepatoma Cell Line Induced Masanori ho, Wataru Yasui, Eikai Kyo, Hiroshi Yokozaki, Hirofumi Nakayama, Hisao Ito, and Eiichi Tañara. by Transforming Growth Factor ßt.Jen-KouLin and Chen-Kung Chou. *301 Characterization of Platelet-derived Growth Factor and Platelet- derived Growth Factor Receptor Expression in Asbestos-induced 389 Eosinophils, Tissue Eosinophilia, and Eosinophil-derived Trans Rat Mesothelioma. Cheryl Walker, Edilberto Bermudez, Wendy forming Growth Factor a in Hamster Oral Carcinogenesis. Stewart, James Bonner, Christopher J. Molloy, and Jeffrey Everitt. Mohammad Ghiabi, George T. Gallagher, and David T. W. Wong. 307 A General Transcription Initiation Factor, Human Transcription Factor III), Overexpressed in Human Lung and Breast Carcinoma S394 Human Xenograft-Nude Mouse Model of Adoptive Immunother- and Rapidly Induced with Serum Stimulation. Chieki Wada, apy with Human Melanoma-specific Cytotoxic T-Cells. Nancy J. Kiyoshi Kasai, Toru Kameya, and Hideki Ohtani. Crowley, Carol E. Vervaert, and Hilliard F. Seigler.

This On« §TheCONTENTS arranged by Subject Category can be found immediately following these CONTENTS.

EOHG-NWC-BNWX Downloaded from cancerres.aacrjournals.org on September 26, 2021. © 1992 American Association for Cancer Research. 400 Anticancer Effects of Free Polyunsaturated Fatty Acids in an Oily LymphographicAgent following IntrahepaticArterialAdministra tion to a Rabbit Bearing VX-2 Tumor. Yoshiki Hayashi, Shoji Advances in Brief Fukushima, Shuichi Kishimoto, Takeo Kawaguchi, Mitsuhiro '"470 Different Effects of Staurosporine, an Inhibitor of Protein Kinases, Numata, Yoshihiro Isoda, Jiro Mirano, and Masahiro Nakano. on the Cell Cycle and Chromatin Structure of Normal and Leu- "*"406 Establishment of a Human t(4;l 1) Leukemia in Severe Combined kemic Lymphocytes. Silvia Bruno, Barbara Ardelt, Janusz S. Skierski, Frank Tráganos,and Zbigniew Darzynkiewicz. Immunodeficient Mice and Successful Treatment Using Anti- CD^ (B43)-Pokeweed Antiviral Protein Immunotoxin. Burkhard 474 Rhabdomyosarcoma Spheroids with Central Proliferation and Jansen, Fatih M. Uckun, Waclaw B. Jaszcz, and John H. Kersey. Differentiation. Ulrich Karbach, Claus-Dieter Gerharz, Karlfried Groebe, Helmut E. Gabbert, and Wolfgang Mueller-Klieser. "M13«tc Protection from l-/3-D-Arabinofuranosylcytosine-induced Alope ^478 Effect of Protein Tyrosine Phosphatase l B Expression on Trans cia by Epidermal Growth Factor and Fibroblast Growth Factor in formation by the Human neu Oncogene. Sheryl Brown-Shimer, the Rat Model. JoaquínJ.Jimenez and Adel A. Yunis. Karen A. Johnson, David E. Hill, and Arthur M. Bruskin. 416 Glycosphingolipids of Various Human Ovarian Tumors: A Signif ^483 Inhibition of Estrogen Receptor Action by a Naturally Occurring icantly High Expression of FSOjGalCer and Lewis Antigen in Variant in Human Breast Tumors. Suzanne A. W. Fuqua, Saundra Mucinous Cystadenocarcinoma. Kazushige Kiguchi, Kiyoshi D. Fitzgerald, D. Craig Allred, Richard M. Elledge, Zafar Nawaz, Takamatsu, Jun Tanaka, Shiro Nozawa, Masao Iwamori, and Donald P. McDonnell, Bert W. O'Malley, Geoffrey L. Greene, Yoshitaka Nagai. and William L. McGuire. *422 Detection of Nuclear Matrix Proteins in Serum from Cancer 487 Interstitial Fluid Pressure in Solid Tumors following Hyperther- Patients. Thomas E. Miller. Lee A. Beausang, Lisa F. Winchell, mia: Possible Correlation with Therapeutic Response. Michael Leunig, Alwin E. Goetz, Marc Dellian, Gerd Zetterer, Fernando and Graham P. Lidgard. Gamarra, Rakesh K. Jain, and Konrad Messmer. *428 Increased Growth of NIH/3T3 Cells by Transfection with Human ^491 Involvement of BCL-2 in Glucocorticoid-induced Apoptosis of pi 20 Complementary DNA and Inhibition by a pi 20 Antisense Human Pre-B-Leukemias. Emad S. Alnemri, Teresa F. Fernandes, Construct. Laszlo Perlaky, Benigno C. Valdez, Rose K. Busch, Subrata Haldar, Carlo M. Croce, and Gerald Litwack. Robert G. Larson, Sissy M. Jhiang, Wei Wei Zhang, Michael Brattain, and Harris Busch.

437 The NZB Mouse as a Model for Chronic Lymphocytic Leukemia. 496 Announcements Eighty-Third Annual Meeting of the AACR Joy A. Phillips, Kumudini Mehta, Cesar Fernandez, and Elizabeth S. Raveché. AACR Special Conferences in Cancer Research Future Annual Meetings of the AACR * 444 Prolonged Decrease of Serum Calcium Concentration by Murine General Motors Cancer Research Foundation Seeks •¿y-InterferoninHypercalcémie,HumanTumor (EC-GI)-bearing Nominations for Annual Journalism Prizes Nude Mice. Kanji Sato, Tomoko Satoh, Kazuo Shizume, Yukiko Recent Deaths Yamakawa, Yoshiyuki Ono, Hiroshi Demura, Takuhiko Akatsu, Calendar of Events Naoyuki Takahashi, and Tatsuo Suda. 498 Errata * 450 Pheochromocytomas and C-Cell Thyroid Neoplasms in Trans- Z-F. Chang et ai, 51: 4724-4728, 1991. genie c-mos Mice: A Model for the Human Multiple Endocrine M. Okoshi et al., 51: 6019-6024. 1991. Neoplasia Type 2 Syndrome. Nicholas Schulz, Friedrich Propst, Michael P. Rosenberg. R. Ilona Linnoila, Richard S. Paules, 499 Author Index Robert Kovatch, Yuko Ogiso, and George Vande Woude. NOTE: AACR forms available in the back of this issue— "•156Leukoregulin and 7-Interferon Inhibit Human Papillomavirus •¿Applicationfor Active and Corresponding Membership Type 16 Gene Transcription in Human Papillomavirus-immortal- •¿Applicationfor Associate Membership ized Human Cervical Cells. Craig D. Woodworth, Ulrike Lichti. •¿AdvanceRegistration Form for the 83rd Annual Meeting Scott Simpson, Charles H. Evans, and Joseph A. DiPaolo. US464 Neutrophil Chemotactic Factors Produced by a Cell Line from Also available in the back of this issue— Thyroid Carcinoma. Minoru Yoshida, Hiromitsu Matsuzaki, GUIDELINES FOR SUBMITTING DISKS TO Kenmei Sakata, Motohiro Takeya, Kazuharu Kato, Seiichi AACR PUBLICATIONS Mizushima, Makoto Kawakita, and Kiyoshi Takatsuki.

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VOLUME 52 •¿NUMBER2

CONTENTS Arranged by Subject Category

280 Growth Kinetics of Microscopic Hepatocellular Neoplasms in Carcinogen-resistant and Carcinogen-responsive Strains of Mice. Perspectives in Cancer Research Thomas D. Pugh and Stanley Goldfarb. 389 Eosinophils, Tissue Eosinophilia, and Eosinophil-derived Trans 249 The Origin of Point Mutations in Human Tumor Cells. forming Growth Factor a in Hamster Oral Carcinogenesis. Bernard S. Strauss. Mohammad Ghiabi, George T. Gallagher, and David T. W. Wong. Advances in Brief "470 Different Effects of Staurosporine, an Inhibitor of Protein Kinases, Endocrinology *290 170-Hydroxysteroid Dehydrogenase Gene Expression in Human on the Cell Cycle and Chromatin Structure of Normal and Leu- kemic Lymphocytes. Silvia Bruno, Barbara Ardelt. Janusz S. Breast Cancer Cells: Regulation of Expression by a Progestin. Skierski, Frank Tráganos,and Zbigniew Darzynkiewicz. Matti Poutanen, Bruno Moncharmont, and Reijo Vihko. 474 Rhabdomyosarcoma Spheroids with Central Proliferation and *334 Inhibition of DNA Synthesis and Growth in Human Breast Differentiation. Ulrich Karbach, Claus-Dieter Gerharz, Karlfried Stromal Cells by Bradykinin: Evidence for Independent Roles of Groebe. Helmut E. Gabbert, and Wolfgang Mueller-Klieser. HIand B: Receptors in the Respective Control of Cell Growth and Phospholipid Hydrolysis. Kirti V. Patel and Michael P. Schrey. f 478 Effect of Protein Tyrosine Phosphatase l B Expression on Trans * 444 Prolonged Decrease of Serum Calcium Concentration by Murine formation by the Human neu Oncogene. Sheryl Brown-Shimer. Karen A. Johnson. David E. Hill, and Arthur M. Bruskin. 7-Interferon in Hypercalcémie,HumanTumor (EC-GI)-bearing >483 Inhibition of Estrogen Receptor Action by a Naturally Occurring Nude Mice. Kanji Sato, Tomoko Satoh. Kazuo Shizume. Yukiko Yamakawa. Yoshiyuki Ono, Hiroshi Demura. Takuhiko Akatsu, Variant in Human Breast Tumors. Suzanne A. W. Fuqua, Naoyuki Takahashi. and Tatsuo Suda. Saundra D. Fitzgerald, D. Craig Allred. Richard M. Elledge, Zafar Nawaz, Donald P. McDonnell, Bert W. O'Malley. Immunology Geoffrey L. Greene, and William L. McGuire. *394 Human Xenograft-Nude Mouse Model of Adoptive Immunother- 487 Interstitial Fluid Pressure in Solid Tumors following Hyperther- apy with Human Melanoma-specific Cytotoxic T-Cells. Nancy J. iniii: Possible Correlation with Therapeutic Response. Michael Crowley. Carol E. Vervaert, and Hilliard F. Seigler. Leunig. Alwin E. Goetz. Marc Dellian, Gerd Zetterer. Fernando Gamarra, Rakesh K. Jain, and Konrad Messmer. Molecular Biology and Genetics ^491 Involvement of BCL-2 in Glucocorticoid-induced Apoptosis of *285 Loss of Heterozygosity at the Human RAPlA/Krec-1 Locus Is a Human Pre-B-Leukemias. Emad S. Alnemri, Teresa F. Fernandes, Rare Event in Colorectal Tumors. Joanne Young, Jeffrey Searle, Subrata Haldar. Carlo M. Croce, and Gerald Litwack. Russell Stitz, Alistair Cowen, Michael Ward, and Georgia Chenevix-Trench.

314 Complementary DNA Cloning, Messenger RNA Expression, and Induction of »-Class Glutathione 5-Transferases in Mouse BASIC SCIENCES Tissues. Timo M. Buetler and David L. Eaton. .11') Isolation and Characterization of a l-/8-D-Arabinofuranosylcyto- Biochemistry and Biophysics sine-resistant Chinese Hamster Ovary Cell Mutant That Is Also "258 Proliferation-linked Regulation of Type II IMP Dehydrogenase X-Ray Sensitive and Is Noncomplementary with Ataxia Telangi- ectasia Cells. Gloria A. Preston, Helen S. Payne, and R. Julian Gene in Human Normal Lymphocytes and UI -60 Leukemic Cells. Preston. Masami Nagai. Yutaka Natsumeda, and George Weber. sk "416 Glycosphingolipids of Various Human OvarianTumors: A Signif .MS Molecular and Cellular Characterization of Human Renal Cell icantly High Expression of I'SO.i GalCer and Lewis Antigen in Carcinoma Cell Lines. P. Anglard. E. Trahan, S. Liu, F. Latif, M. J. Merino, M. I. Lerman, B. Zbar, and W. M. Linchan. Mucinous Cystadenocarcinoma. Kazushige Kiguchi, Kiyoshi Takamatsu. Jun Tanaka, Shiro Nozawa. Masao Iwamori, and *450 Pheochromocytomas and C-Cell Thyroid Neoplasms in Trans- Yoshitaka Nagai. genie c-mos Mice: A Model for the Human Multiple Endocrine Neoplasia Type 2 Syndrome. Nicholas Schulz. Friedrich Propst. Carcinogenesis Michael P. Rosenberg, R. Ilona Linnoila, Richard S. Paules, 267 Molecular Dosimetry in Rat Urine of Aflatoxin-/V7-guanine and Robert Kovatch. Yuko Ogiso, and George Vande Woude. Other Aflatoxin Metabolites by Multiple Monoclonal Antibody Preclinical Pharmacology and Experimental Therapeutics Affinity Chromatograph) and Immunoaffinity/High Perform ance Liquid Chromatograph)'. John D. Groopman. Julia A. *3k 262 The Effects of Interleukin 2 and «-InterferonAdministrationon Hasler, Laura J. Trudel. Anthony Pikul, Paul R. Donahue, and Hepatic Drug Metabolism in Mice. SherryS. Ansher, Raj K. Puri. Gerald N. Wogan. Walter C. Thompson, and William H. Habig.

' Indicates studies using human-derived material.

Downloaded from cancerres.aacrjournals.org on September 26, 2021. © 1992 American Association for Cancer Research. * 357 A Quantitative Analysis of Tumor-specific Monoclonal Antibody *422 Detection of Nuclear Matrix Proteins in Serum from Cancer Uptake by Human Melanoma Xenografts: Effects of Antibody Patients. Thomas E. Miller, Lee A. Beausang, Lisa F. Winchell, Immunologie-ai Properties and Tumor Antigen Expression and Graham P. Lidgard. Levels. Ty R. Shockley, Ke Lin, Cynthia Sung, Janice A. Nagy, * 428 Increased Growth of NIH/3T3 Cells by Transfection with Human Ronald G. Tompkins, Robert L. Dedrick, Harold F. Dvorak, pi 20 Complementary DNA and Inhibition by a pi 20 Antisense and Martin L. Yarmush. Construct. Laszlo Perlaky, Benigno C. Valdez, Rose K. Busch, *367 Spatial Distribution of Tumor-specific Monoclonal Antibodies Robert G. Larson, Sissy M. Jhiang, Wei Wei Zhang, Michael in Human Melanoma Xenografts. Ty R. Shockley, Ke Lin, Brattain, and Harris Busch. Janice A. Nagy, Ronald G. Tompkins, Martin L. Yarmush, and 437 The NZB Mouse as a Model for Chronic Lymphocytic Leukemia. Harold F. Dvorak. Joy A. Phillips, Kumudini Mehta, Cesar Fernandez, and Elizabeth * 377 Predicted and Observed Effects of Antibody Affinity and Antigen S. Raveché. Density on Monoclonal Antibody Uptake in Solid Tumors. *464 Neutrophil Chemotactic Factors Produced by a Cell Line from Cynthia Sung, Ty R. Shockley, Paul F. Morrison, Harold F. Thyroid Carcinoma. Minoru Yoshida, Hiromitsu Matsuzaki, Dvorak, Martin L. Yarmush, and Robert L. Dedrick. Kenmei Sakata, Motohiro Takeya, Kazuharu Kato, Seiichi 400 Anticancer Effects of Free Polyunsaturated Fatty Acids in an Oily Mizushima, Makoto Kawakita, and Kiyoshi Takatsuki. LymphographicAgent following IntrahepaticArterial Administra tion to a Rabbit Bearing VX-2 Tumor. Yoshiki Hayashi, Shoji Virology Fukushima, Shuichi Kishimoto, Takeo Kawaguchi, Mitsuhiro sk'456 Leukoregulin and •¿y-InterferonInhibitHuman Papillomavirus Numata, Yoshihiro Isoda, Jiro Hirano, and Masahiro Nakano. Type 16 Gene Transcription in Human Papillomavirus-immortal- 406 Establishment of a Human t(4;l 1) Leukemia in Severe Combined ized Human Cervical Cells. Craig D. Woodworth, Ulrike Lichti, Immunodeficient Mice and Successful Treatment Using Anti- Scott Simpson, Charles H. Evans, and Joseph A. DiPaolo. CD19 (B43)-Pokeweed Antiviral Protein Immunotoxin. Burkhard Jansen, Fatih M. Uckun, Waclaw B. Jaszcz, and John H. Kersey. *4n Protection from l-/9-D-Arabinofuranosylcytosine-inducedAlope CLINICAL AND EPIDEMIOLOGICAL cia by EpidermalGrowth Factor and Fibroblast Growth Factor in INVESTIGATIONS the Rat Model. JoaquínJ.Jimenez and Adel A. Yunis. 254 Cigarette Smoking and Cancers of the Renal Pelvis and Ureter. Tumor Biology Joseph K. McLaughlin, Debra T. Silverman, Ann W. Hsing, * 275 Inhibition of Colon and Breast Carcinoma Cell Growth by Inter- Ronald K. Ross, Janet B. Schoenberg, Mimi C. Yu, Annette leukin-4. Masakazu Toi, Roy Bicknell, and Adrian L. Harris. Stemhagen, Charles F. Lynch, William J. Blot, and Joseph F. Fraumeni, Jr. * 295 Growth Inhibition of Transforming Growth Factor ßonHuman Gastric Carcinoma Cells: Receptor and Postreceptor Signaling. Masanori Ito, Wataru Yasui, Eikai Kyo, Hiroshi Yokozaki, 496 Announcements Hirofumi Nakayama, Hisao Ito, and Eiichi Tahara. Eighty-Third Annual Meeting of the AACR *301 Characterization of Platelet-derived Growth Factor and Platelet- AACR Special Conferences in Cancer Research derived Growth Factor Receptor Expression in Asbestos-induced Future Annual Meetings of the AACR Rat Mesothelioma. Cheryl Walker, Edilberto Bermudez, Wendy General Motors Cancer Research Foundation Seeks Stewart, James Bonner, Christopher J. Molloy, and Jeffrey Everitt. Nominations for Annual Journalism Prizes Recent Deaths * 307 A General Transcription Initiation Factor, Human Transcription Calendar of Events Factor IID, Overexpressed in Human Lungand Breast Carcinoma and Rapidly Induced with Serum Stimulation. Chieki Wada, 498 Errata Z-F. Chang et al., 51: 4724-4728, 1991. Kiyoshi Kasai, Toru Kameya, and Hideki Ontani. H. Okoshi et al., 51: 6019-6024, 1991. *32S Mechanism of Cross-Resistance to a Camptothecin Analogue 499 Author Index (CPT-11) in a Human Ovarian Cancer Cell Line Selected by Cisplatin. Shigeki Numi, Kazuhiko Nakagawa, Yoshikazu Sugimoto, Kazuto Nishio, Yasuhiro Fujiwara, Shiro Yokoyama, NOTE: AACR forms available in the back of this issue— Yoshiteru Terashima, and Nagahiro Saijo. •¿Applicationfor Active and Corresponding Membership *341 Transforming Growth Factor-a Acts as an Autocrine Growth •¿Applicationfor Associate Membership Factor in Ovarian Carcinoma Cell Lines. Kurt Stromberg, •¿AdvanceRegistration Form for the 83rd Annual Meeting Theodore J. Collins IV, Alfred W. Gordon, Carolyn L. Jackson, and Gibbes R. Johnson. Also available in the back of this issue— 385 In Vitro Apoptosis in the Human Hepatoma Cell Line Induced GUIDELINES FOR SUBMITTING DISKS TO by Transforming Growth Factor ßt.Jen-KouLin and Chen-Kung AACR PUBLICATIONS Chou.

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Cancer Res 1992;52:249-498.

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