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Clinical Characteristics of Migraine in Twelve Sudanese Families

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Clinical Characteristics of Migraine in Twelve Sudanese Families Journal of Neurology & Stroke Clinical Characteristics of Migraine in Twelve Sudanese families Abstract Clinical Paper Introduction: Volume 7 Issue 5 - 2017 were compiled according to certain criteria set by the international headache society Migraine headache is characterized by certain clinical features that headaches for both clinical practice and research studies. (IHS) so as to provide a standardized definition, diagnosis and classification of Aims: The aim of this study is to determine the clinical characteristics of migraine in 1Department of physiology, National Ribat University, Sudan Sudanese families and whether they adhere to international criteria set by the IHS. 2Faculty of medicine, University of Gezira, Sudan 3Almaarefa Colleges- Faculty of Medicine, Saudi Arabia Patients and Methods: case, a detailed validated questionnaire based on the IHS was distributed to all *Corresponding author: family members affected Following as well as the non-affected description after of the giving clinically an informed diagnosed consent. index medicine, National Ribat University, Khartoum, Sudan, Tel: 00249-912397699; Email:M Salah Elmagzoub, Faculty of twoThe neurologists.responding family members were then classified as migraineurs and non- Received: August 27, 2017 | Published: October 04, 2017 migraineurs after analysis of the questionnaire and confirmation of the diagnosis by Results: 107 were migraineurs (70.1% females, 29.9 % males). Both migraine with aura (MA) and migraine From without the 175 aura(MO) subjects whoco-exist agreed in theto participatesame family (from and twelveeven in pedigrees) the same individual with the most common migraine type being MO (51.4%,N=55), followed by MA+MO (32.7%, N=35) and MA (15.9 %, N=17). Unilateral location, presence of 0.000). nausea, photophobia and aggravation by exercise showed significant results (P value Conclusions: The presentation of migraine headache showed results similar to that described by the HIS 2nd edition in most of the criteria and differed in others. Co- morbidity with a number of diseases and migraine coexist. Keywords: Clinical Characteristics; Migraine with aura (MA); Migraine without aura(MO); International headache society (IHS) Introduction diagnostic criteria however, were introduced by the International The quality of life of a migraineur affects his/her familial HeadacheA comprehensive Society (IHS) and in 1988more [7]. detailed In 1993, classification Blau (1993) andhad and social situations, in addition to the impaired physical and questioned the validity of the migraine criteria as patients may emotional well being [1]. In the Global Burden of Disease Survey 2010, migraine was ranked as the third most prevalent disorder revisedsometimes and experienceupdated in attacks2004 (2 thatnd Edition) are difficult to include to categorize 14 types [2]. Migraine is a demanding and expensive disorder, beside ofaccording head pain to these with criteria migraine [8]. Thisregarded classification as group was one. then Migraine further and seventh-highest specific cause of disability worldwide recurrent absenteeism from the work and hence diminished the expensive medical costs there is a financial burden due to productivity [3]. migraineas a primary without head aura pain MO beingwas furtherthe most classified common typesby the [9]. same The Migraine headache was known and described since ancient internationalclassification intoheadache six subgroups, society recently with migraine released with a beta aura version MA and of times. Hippocrates described the visual symptoms of migraine the third improved extensive criteria in 2013 [10]. in 400 BC as a shiny light, usually in the right eye, followed by Migraine has a strong familial aggregation with about 50% severe pain beginning in the temples and eventually reaching the entire head and neck area. Hippocrates also noted the association between headache and various activities such as exercise [4]. factorsin the first [11,12]. degree Co-morbidities relatives. Genetic of migraine contribution and toseveral migraine other is Yet, disordersdiverse and have subject been to significantreported in modification clinical series, by environmental case-control were provided by Aretaeus of Cappadocia during the 1st century studies, and epidemiologic surveys [13]. Cardiovascular, A.D. [5]. the Nevertheless first specific it descriptions is Galen who of used variable the term types “hemicrania” of headache gastrointestinal, neurologic, and psychiatric systems and allergies to describe the unilateral pain sensation [6]. as asthma are the most widely reported co-morbid disorders [14]. Submit Manuscript | http://medcraveonline.com J Neurol Stroke 2017, 7(5): 00250 Copyright: Clinical Characteristics of Migraine in Twelve Sudanese families ©2017 ELmagzoub et al. 2/5 As Migraine is a subjective disease, a detailed history is crucial same individual with the most common migraine type being MO in its diagnosis. The history, however, should be taken meticulously (51.4%, N=55), followed by MA+MO (32.7%, N=35) and MA (15.9 by an expert, together with a clinical examination performed by a neurologist [15]. The diagnostic criteria set by the IHS have been the basis for migraine questionnaires’ [16]. %, N=17) Figure 2. In Sudan, Neurologists claim that migraine headache is very common but unfortunately no studies regarding the prevalence of migraine headache were done yet. Apart from the WHO data published data concerning migraine. Therefore our current appeared in the Local Profil map [17], we could not find any parameters in order to have a clear picture of the disorder putting inresearch mind intendedthe unique to ethnicidentify variations, migraine profilethe different using differentcultural backgrounds, the consanguinity marriages and the diverse climatic changes in a vast country like ours. The present work aim to study the clinical characteristics of migraine in order to set the baseline that will further include a genetic, evoked potentials, neuroimaging and interleukins profile. Material and Methods Figure 1: circle or square denotes subjects affected with migraine Study design and Subjects Family One ; a circle is for female and square for male, Filled and the faculty of medicine, National Ribat Teaching Hospital, The study was carried out in El Magzoub neuroscience centre informationbetween 2008 was and collected 2010. One initially hundred from seventy the description five subjects of from the twelve Sudanese families were included in this study. Family diagnosedclinically studied index case index a detailedcase (proband) validated that questionnaire was first seen based at the on theneurology HIS [4,6] referred was distributed clinic. Following to all family the description members affectedof the clinically as well as non-affected after giving an informed consent. The responding offamily the diagnosis members by were two neurologists.then classified Only as the migraineurs data of migraineurs or non- weremigraineurs included after in this analysis study. of the questionnaire and confirmation Data analysis Figure 2: Types of migraine in the study group. Analysis of the clinical data and the questionnaire was Types of migraine against gender and against duration of carried out using STATA statistical package and Vassarstat online bethe noted attack that are unilateral shown in location, Figures presence 3 & 4 respectively. of nausea, photophobia Associated computational statistical software. P value < 0.05 is considered symptoms and triggering factors are shown in Figure 5. It should significant. Approval for this study was given from ethical by all participants. 0.000). Motor disorders, on the other hand, were not frequent committee, university of Gezira. A written informed was signed and aggravation by exercise showed significant results (P value Results different families experienced transient motor weakness typical ofeven hemiplegic in MA (P migraine value 0.23). once Only in their 4.8% life. of migraineurs (N=5) from A cross sectional study that involved 175 subjects from 12 large Sudanese families; Afroasiatics (Ja’afra, Jaa’lia, Shawiga, Kwahla) In migraine with aura patients, the most common aura and Nilosaharan (Halfaween and Mahas). 107 migraineurs were symptoms are visual (70%) followed by somatosensory (23.4%) included in this study. Detailed history of the twelve pedigrees led and motor (6.5%). The most common co-morbid disorders with migraine within the twelve families were sinusitis (100%) followed by hypertension (91.7%), irritable bowel syndrome to identification of 392 subjects. 189 (48.2%) were migraineurs (83.3%) asthma (75%), and diabetes (66.7%). Epilepsy, werewhile migraineurs203 (51.8%) (70.1% were unaffected. females, 29.9 Figure % 1males). shows Analysisone of the of psychiatric disorders and depression were associated with thelargest questionnaire families. From revealed the 175 that who both agreed migraine to participate, with aura 107and migraine in about 50% of families. migraine without aura co-exist in the same family and even in the Citation: 00250. DOI: 10.15406/jnsk.2017.07.00250 ELmagzoub MS, Ibrahim SMH, Abdalla SF (2017) Clinical Characteristics of Migraine in Twelve Sudanese families. J Neurol Stroke 7(5): Copyright: Clinical Characteristics of Migraine in Twelve Sudanese families ©2017 ELmagzoub et al. 3/5 Regarding acute migraine treatment, only 23.4% of migraineurs claimed that they benefit from ergotamines while migraineurs88.7% use simple (14%) analgesics. use antiemetics Forty
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