Big Challenges for Statisticians
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Imaging Genetic Strategies for Predicting the Quality of Sleep Using Depression-Specific Biomarkers
Imaging genetic strategies for predicting the quality of sleep using depression-specific biomarkers Mansu Kim 1, Xiaohui Yao 1, Bo-yong Park 2, Jingwen Yan 3, and Li Shen1,* 1Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, USA 2McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Canada 3Department of BioHealth Informatics, Indiana University School of Informatics and Computing, Indiana University, USA * Correspondence to [email protected] Overview Joint-connectivity-based sparse CCA Background: Sleep is an essential phenomenon for SNP connectivity Imaging genetics model: The joint-connectivity-based sparse canonical ··· X* samples × maintaining good health and wellbeing [1]. correlation analysis (JCB-SCCA) was applied on preprocessed features n Some studies reported that genetic and p SNPs (Figure 1). JCB-SCCA has an advantage for incorporating connectivity Loading vector u Maximum imaging biomarkers that depression is information and can handle multi-modal neuroimaging datasets. correlation Brain associated with sleep disorder [2]–[4]. connectivity ··· Prior biological knowledge: The average connectivity matrix computed ··· K samples Y* modalitiesn × Imaging genetics: Many studies adopted imaging from the HCP dataset and linkage disequilibrium obtained from 1,000 q voxels genetics methodology to find associations genome project were used as the prior connectivity information of the K = 2 Loading vector V between imaging and genetic biomarkers. In algorithm. The parameters of the algorithm were tuned jointly by nested K = 1 this study, we examine the imaging genetics five-fold cross-validation. Figure 1. JCB-SCCA association in depression and extract biomarkers for predicting the quality of sleep. Experiments and Results Prediction task: We built a prediction model for the Pittsburgh sleep quality index (PSQI) using the identified biomarkers. -
Management of Large Sets of Image Data Capture, Databases, Image Processing, Storage, Visualization Karol Kozak
Management of large sets of image data Capture, Databases, Image Processing, Storage, Visualization Karol Kozak Download free books at Karol Kozak Management of large sets of image data Capture, Databases, Image Processing, Storage, Visualization Download free eBooks at bookboon.com 2 Management of large sets of image data: Capture, Databases, Image Processing, Storage, Visualization 1st edition © 2014 Karol Kozak & bookboon.com ISBN 978-87-403-0726-9 Download free eBooks at bookboon.com 3 Management of large sets of image data Contents Contents 1 Digital image 6 2 History of digital imaging 10 3 Amount of produced images – is it danger? 18 4 Digital image and privacy 20 5 Digital cameras 27 5.1 Methods of image capture 31 6 Image formats 33 7 Image Metadata – data about data 39 8 Interactive visualization (IV) 44 9 Basic of image processing 49 Download free eBooks at bookboon.com 4 Click on the ad to read more Management of large sets of image data Contents 10 Image Processing software 62 11 Image management and image databases 79 12 Operating system (os) and images 97 13 Graphics processing unit (GPU) 100 14 Storage and archive 101 15 Images in different disciplines 109 15.1 Microscopy 109 360° 15.2 Medical imaging 114 15.3 Astronomical images 117 15.4 Industrial imaging 360° 118 thinking. 16 Selection of best digital images 120 References: thinking. 124 360° thinking . 360° thinking. Discover the truth at www.deloitte.ca/careers Discover the truth at www.deloitte.ca/careers © Deloitte & Touche LLP and affiliated entities. Discover the truth at www.deloitte.ca/careers © Deloitte & Touche LLP and affiliated entities. -
A 3D Interactive Multi-Object Segmentation Tool Using Local Robust Statistics Driven Active Contours
A 3D interactive multi-object segmentation tool using local robust statistics driven active contours The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Gao, Yi, Ron Kikinis, Sylvain Bouix, Martha Shenton, and Allen Tannenbaum. 2012. A 3D Interactive Multi-Object Segmentation Tool Using Local Robust Statistics Driven Active Contours. Medical Image Analysis 16, no. 6: 1216–1227. doi:10.1016/j.media.2012.06.002. Published Version doi:10.1016/j.media.2012.06.002 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:28548930 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA NIH Public Access Author Manuscript Med Image Anal. Author manuscript; available in PMC 2013 August 01. NIH-PA Author ManuscriptPublished NIH-PA Author Manuscript in final edited NIH-PA Author Manuscript form as: Med Image Anal. 2012 August ; 16(6): 1216–1227. doi:10.1016/j.media.2012.06.002. A 3D Interactive Multi-object Segmentation Tool using Local Robust Statistics Driven Active Contours Yi Gaoa,*, Ron Kikinisb, Sylvain Bouixa, Martha Shentona, and Allen Tannenbaumc aPsychiatry Neuroimaging Laboratory, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115 bSurgical Planning Laboratory, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115 cDepartments of Electrical and Computer Engineering and Biomedical Engineering, Boston University, Boston, MA 02115 Abstract Extracting anatomical and functional significant structures renders one of the important tasks for both the theoretical study of the medical image analysis, and the clinical and practical community. -
Accurate Segmentation of Brain MR Images
Accurate segmentation of brain MR images Master of Science Thesis in Biomedical Engineering ANTONIO REYES PORRAS PÉREZ Department of Signals and Systems Division of Biomedical Engineering CHALMERS UNIVERSITY OF TECHNOLOGY Göteborg, Sweden, 2010 Report No. EX028/2010 Abstract Full brain segmentation has been of significant interest throughout the years. Recently, many research groups worldwide have been looking into development of patient-specific electromagnetic models for dipole source location in EEG. To obtain this model, accurate segmentation of various tissues and sub-cortical structures is thus required. In this project, the performance of three of the most widely used software packages for brain segmentation has been analyzed: FSL, SPM and FreeSurfer. For the analysis, real images from a patient and a set of phantom images have been used in order to evaluate the performance r of each one of these tools. Keywords: dipole source location, brain, patient-specific model, image segmentation, FSL, SPM, FreeSurfer. Acknowledgements To my advisor, Antony, for his guidance through the project. To my partner, Koushyar, for all the days we have spent in the hospital helping each other. To the staff in Sahlgrenska hospital for their collaboration. To MedTech West for this opportunity to learn. Table of contents 1. Introduction ......................................................................................................................................... 1 2. Magnetic resonance imaging .............................................................................................................. -
1 Structural and Functional Alterations in the Brain Gray Matter
Structural and functional alterations in the brain gray matter among first-degree relatives of schizophrenia patients: a multimodal meta-analysis of fMRI and VBM studies Running title: Familial risk for schizophrenia and alterations in the brain Aino I. L. Saarinen, PhD1,2,3,*, Sanna Huhtaniska, MD, PhD4, Juho Pudas, MB3, Lassi Björnholm, MD3, Tuomas Jukuri, MD, PhD3, Jussi Tohka, MD, PhD5, Niklas Granö, PhD6, Jennifer H. Barnett, PhD7,8, Vesa Kiviniemi, MD, PhD9,10, Juha Veijola, MD, PhD3,10,11, Mirka Hintsanen, PhD1, Johannes Lieslehto, MD, PhD 12 1 Research Unit of Psychology, University of Oulu, Finland 2 Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland 3 Research Unit of Clinical Neuroscience, Department of Psychiatry, University of Oulu, Finland 4 Center for Life Course Health Research, University of Oulu, Finland 5 A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland 6 Helsinki University Hospital, Department of Adolescent Psychiatry, Finland 7 Cambridge Cognition, Cambridge, UK 8 Department of Psychiatry, University of Cambridge, Cambridge, UK 9 Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland 10 Department of Psychiatry, Oulu University Hospital, Oulu, Finland 11 Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland 12 Section for Neurodiagnostic Applications, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Bavaria, * Corresponding author: Aino Saarinen. Department of Psychology and Logopedics, Faculty of Medicine, Haartmaninkatu 3, P.O. Box 21, 00014 University of Helsinki, Finland. E-mail: [email protected], Tel.: +35844 307 1204. 1 Abstract Objective: Schizophrenia has one of the highest heritability estimates in psychiatry, but the genetically- based underlying neuropathology has mainly remained unclear. -
Simultaneous PET/MRI for Connectivity Mapping: Quantitative Methods in Clinical Setting
UNIVERSITY OF PADOVA Department of Information Engineering Ph.D. School on Information Engineering Curriculum: Bioengineering - Cycle: XXX Simultaneous PET/MRI for Connectivity Mapping: Quantitative Methods in Clinical Setting Headmaster of the School: Prof. Andrea NEVIANI Supervisor: Prof. Alessandra BERTOLDO PhD. Candidate: Eng. Erica SILVESTRI 2018 iii University of Padova Abstract Ph.D. School on Information Engineering Simultaneous PET/MRI for Connectivity Mapping: Quantitative Methods in Clinical Setting by Eng. Erica SILVESTRI In recent years, the study of brain connectivity has received growing inter- est from neuroscience field, from a point of view both of analysis of patho- logical condition and of a healthy brain. Hybrid PET/MRI scanners are promising tools to study this complex phenomenon. This thesis presents a general framework for the acquisition and analysis of simultaneous multi- modal PET/MRI imaging data to study brain connectivity in a clinical set- ting. Several aspects are faced ranging from the planning of an acquisition protocol consistent with clinical constraint to the off-line PET image recon- struction, from the selection and implementation of methods for quantifying the acquired data to the development of methodologies to combine the com- plementary informations obtained with the two modalities. The developed analysis framework was applied to two different studies, a first conducted on patients affected by Parkinson’s Disease and dementia, and a second one on high grade gliomas, as proof of concept evaluation that the pipeline can be extended in clinical settings. v Università degli Studi di Padova Sommario Scuola di Dottorato in Ingegneria dell’Informazione Acquisizioni simultanee PET/MR per lo studio della connettività: metodi quantitativi in ambito clinico di Ing. -
Polygenic Evidence and Overlapped Brain Functional Connectivities For
Sun et al. Translational Psychiatry (2020) 10:252 https://doi.org/10.1038/s41398-020-00941-z Translational Psychiatry ARTICLE Open Access Polygenic evidence and overlapped brain functional connectivities for the association between chronic pain and sleep disturbance Jie Sun 1,2,3,WeiYan2,Xing-NanZhang2, Xiao Lin2,HuiLi2,Yi-MiaoGong2,Xi-MeiZhu2, Yong-Bo Zheng2, Xiang-Yang Guo3,Yun-DongMa2,Zeng-YiLiu2,LinLiu2,Jia-HongGao4, Michael V. Vitiello 5, Su-Hua Chang 2,6, Xiao-Guang Liu 1,7 and Lin Lu2,6 Abstract Chronic pain and sleep disturbance are highly comorbid disorders, which leads to barriers to treatment and significant healthcare costs. Understanding the underlying genetic and neural mechanisms of the interplay between sleep disturbance and chronic pain is likely to lead to better treatment. In this study, we combined 1206 participants with phenotype data, resting-state functional magnetic resonance imaging (rfMRI) data and genotype data from the Human Connectome Project and two large sample size genome-wide association studies (GWASs) summary data from published studies to identify the genetic and neural bases for the association between pain and sleep disturbance. Pittsburgh sleep quality index (PSQI) score was used for sleep disturbance, pain intensity was measured by Pain Intensity Survey. The result showed chronic pain was significantly correlated with sleep disturbance (r = 0.171, p-value < 0.001). Their genetic correlation was rg = 0.598 using linkage disequilibrium (LD) score regression analysis. Polygenic score (PGS) association analysis showed PGS of chronic pain was significantly associated with sleep and vice versa. 1234567890():,; 1234567890():,; 1234567890():,; 1234567890():,; Nine shared functional connectivity (FCs) were identified involving prefrontal cortex, temporal cortex, precentral/ postcentral cortex, anterior cingulate cortex, fusiform gyrus and hippocampus. -
An Open-Source Research Platform for Image-Guided Therapy
Int J CARS DOI 10.1007/s11548-015-1292-0 ORIGINAL ARTICLE CustusX: an open-source research platform for image-guided therapy Christian Askeland1,3 · Ole Vegard Solberg1 · Janne Beate Lervik Bakeng1 · Ingerid Reinertsen1 · Geir Arne Tangen1 · Erlend Fagertun Hofstad1 · Daniel Høyer Iversen1,2,3 · Cecilie Våpenstad1,2 · Tormod Selbekk1,3 · Thomas Langø1,3 · Toril A. Nagelhus Hernes2,3 · Håkon Olav Leira2,3 · Geirmund Unsgård2,3 · Frank Lindseth1,2,3 Received: 3 July 2015 / Accepted: 31 August 2015 © The Author(s) 2015. This article is published with open access at Springerlink.com Abstract Results The validation experiments show a navigation sys- Purpose CustusX is an image-guided therapy (IGT) research tem accuracy of <1.1mm, a frame rate of 20 fps, and latency platform dedicated to intraoperative navigation and ultra- of 285ms for a typical setup. The current platform is exten- sound imaging. In this paper, we present CustusX as a robust, sible, user-friendly and has a streamlined architecture and accurate, and extensible platform with full access to data and quality process. CustusX has successfully been used for algorithms and show examples of application in technologi- IGT research in neurosurgery, laparoscopic surgery, vascular cal and clinical IGT research. surgery, and bronchoscopy. Methods CustusX has been developed continuously for Conclusions CustusX is now a mature research platform more than 15years based on requirements from clinical for intraoperative navigation and ultrasound imaging and is and technological researchers within the framework of a ready for use by the IGT research community. CustusX is well-defined software quality process. The platform was open-source and freely available at http://www.custusx.org. -
Medical Image Processing Software
Wohlers Report 2018 Medical Image Processing Software Medical image Patient-specific medical devices and anatomical models are almost always produced using radiological imaging data. Medical image processing processing software is used to translate between radiology file formats and various software AM file formats. Theoretically, any volumetric radiological imaging dataset by Andy Christensen could be used to create these devices and models. However, without high- and Nicole Wake quality medical image data, the output from AM can be less than ideal. In this field, the old adage of “garbage in, garbage out” definitely applies. Due to the relative ease of image post-processing, computed tomography (CT) is the usual method for imaging bone structures and contrast- enhanced vasculature. In the dental field and for oral- and maxillofacial surgery, in-office cone-beam computed tomography (CBCT) has become popular. Another popular imaging technique that can be used to create anatomical models is magnetic resonance imaging (MRI). MRI is less useful for bone imaging, but its excellent soft tissue contrast makes it useful for soft tissue structures, solid organs, and cancerous lesions. Computed tomography: CT uses many X-ray projections through a subject to computationally reconstruct a cross-sectional image. As with traditional 2D X-ray imaging, a narrow X-ray beam is directed to pass through the subject and project onto an opposing detector. To create a cross-sectional image, the X-ray source and detector rotate around a stationary subject and acquire images at a number of angles. An image of the cross-section is then computed from these projections in a post-processing step. -
Local Connectome Phenotypes Predict Social, Health, and Cognitive Factors
RESEARCH Local connectome phenotypes predict social, health, and cognitive factors 1 2,3 4,5 Michael A. Powell , Javier O. Garcia , Fang-Cheng Yeh , 2,3,6 7 Jean M. Vettel , and Timothy Verstynen 1Department of Mathematical Sciences, United States Military Academy, West Point, NY, USA 2U.S. Army Research Laboratory, Aberdeen Proving Ground, MD, USA 3Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA 4Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA 5Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA 6Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, USA 7 an open access journal Department of Psychology and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA Keywords: Local connectome, White matter, Individual differences, Behavior prediction, Structural connectivity ABSTRACT The unique architecture of the human connectome is defined initially by genetics and subsequently sculpted over time with experience. Thus, similarities in predisposition and experience that lead to similarities in social, biological, and cognitive attributes should also be reflected in the local architecture of white matter fascicles. Here we employ a method known as local connectome fingerprinting that uses diffusion MRI to measure the fiber-wise characteristics of macroscopic white matter pathways throughout the brain. This Citation: Powell, M. A., Garcia, J. O., fingerprinting approach was applied to a large sample (N = 841) of subjects from the Yeh, F.-C., Vettel, J. M., & Verstynen, T. (2017). Local connectome phenotypes Human Connectome Project, revealing a reliable degree of between-subject correlation in predict social, health, and cognitive factors. -
Proteomic Analysis of Postsynaptic Proteins in Regions of the Human Neocortex
Proteomic analysis of postsynaptic proteins in regions of the human neocortex Marcia Roy1*, Oksana Sorokina2*, Nathan Skene1, Clemence Simonnet1, Francesca Mazzo3, Ruud Zwart3, Emanuele Sher3, Colin Smith1, J Douglas Armstrong2 and Seth GN Grant1. * equal contribution Author Affiliations: 1. Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom 2. School of Informatics, University of Edinburgh, Edinburgh, EH8 9AB, United Kingdom 3. Lilly Research Centre, Eli Lilly & Company, Erl Wood Manor, Windlesham, GU20 6PH, United Kingdom 1 Abstract: The postsynaptic proteome of excitatory synapses comprises ~1,000 highly conserved proteins that control the behavioral repertoire and mutations disrupting their function cause >130 brain diseases. Here, we document the composition of postsynaptic proteomes in human neocortical regions and integrate it with genetic, functional and structural magnetic resonance imaging, positron emission tomography imaging, and behavioral data. Neocortical regions show signatures of expression of individual proteins, protein complexes, biochemical and metabolic pathways. The compositional signatures in brain regions involved with language, emotion and memory functions were characterized. Integrating large-scale GWAS with regional proteome data identifies the same cortical region for smoking behavior as found with fMRI data. The neocortical postsynaptic proteome data resource can be used to link genetics to brain imaging and behavior, and to study the role of postsynaptic proteins in localization of brain functions. 2 Introduction: For almost two centuries, scientists have pursued the study of localization of function in the human cerebral neocortex using diverse methods including neuroanatomy, electrophysiology, imaging and gene expression studies. The frontal, parietal, temporal and occipital lobes of the neocortex have been commonly subdivided into Brodmann areas (BA)1 based on cytoarchitectural features, and specific behavioral functions have been ascribed to these regions. -
A Critical Look at Connectomics
EDITORIAL A critical look at connectomics There is a public perception that connectomics will translate directly into insights for disease. It is essential that scientists and funding institutions avoid misrepresentation and accurately communicate the scope of their work. onnectomes are generating interest and excitement, both among nervous system, dubbed the classic connectome because it is currently neuroscientists and the public. This September, the first grants the only wiring diagram for an animal’s entire nervous system at the level Cunder the Human Connectome Project, totaling $40 million of the synapse. Although major neurobiological insights have been made over 5 years, were awarded by the US National Institutes of Health using C. elegans and its known connectivity and genome, there are still (NIH). In the public arena, striking, colorful pictures of human brains many questions remaining that can only be answered by hypothesis-driven have accompanied claims that imply that understanding the complete experiments. For example, we still don’t completely understand the process connectivity of the human brain’s billions of neurons by a trillion synapses of axon regeneration, relevant to spinal cord injury in humans, in this is not only possible, but that this will also directly translate into insights comparatively simple system. Thus, a connectome, at any resolution, is for neurological and psychiatric disorders. Even a press release from only one of several complementary tools necessary to understand nervous the NIH touted that the Human Connectome Project would map the system disease and injury. wiring diagram of the entire living human brain and would link these There are substantial efforts aimed at generating connectomes for circuits to the full spectrum of brain function in health and disease.