Sexually Transmitted Diseases Dr

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Sexually Transmitted Diseases Dr FAST FACTS FOR BOARD REVIEW Series Editor: William W. Huang,MD,MPH W. Series Editor:William Rita Pichardo-Geisinger, MD Rita Pichardo-Geisinger, Diseases Sexually Transmitted Disease Laboratory (Synonym[s]) Etiology Clinical Features Diagnosis Treatment Other Features Chancroid Haemophilus Incubation period: 3–7 d; erythematous Small Oral azithromycin 1 g SD; Prevalent in (soft chancre, ducreyi papule, pustule, and then painful ulcer gram-negative IM ceftriaxone 250 mg SD; promiscuous ulcus molle) on the internal and/or external surface bacilli (school oral ciprofloxacin 500 mg high-risk groups; of the prepuce, coronal sulcus, or of fish pattern); twice daily for 3 d; oral enhances HIV around the frenulum in men; introital isolation in culture erythromycin base transmission; and/or perianal area or on the cervix or (not available 500 mg 4 times daily for 7 d coinfection with vaginal wall in women; painful inguinal commercially) syphilis or herpes lymphadenitis, usually unilateral simplex virus is possible Congenital Treponema Marasmic syphilis, snuffles, perioral/ 19S antibodies on Aqueous crystalline penicillin G syphilis pallidum perianal fissures, lymphadenitis; late chromatography, 100,000–150,000 U/kg congenital syphilis: Hutchinson teeth, FTA-ABS 19S daily administered as interstitial keratitis IgM test, and 50,000 U/kg IV dose every IgM ELISA 12 h during the first 7 d of life and every 8 h thereafter for a total of 10 d; procaine penicillin G 50,000 U/kg IM in a single daily dose for 10 d Gonorrhea Neisseria Incubation period: 1–14 d; dysuria, Gram or Dual treatment with IM Preventive gonorrhoeae urethral purulent discharge; vaginal methylene blue ceftriaxone 250 mg SD and strategies for noconflictofinterest. The authorreports Winston-Salem, NorthCarolina. BaptistMedicalCenter, Forest Wake ofDermatology, isAssociateProfessor Pichardo-Geisinger Dr. discharge, intermenstrual bleeding, staining oral azithromycin 1 g SD ophthalmia menorrhagia, and inflammation of the (gram-negative (recommended by CDC neonatorum Bartholin glands in women; primary diplococci in as first-line treatment); include topical site in women is the endocervical PMNs); culture: IM ceftriaxone 250 mg SD; silver nitrate canal; 10% of men and 50% of women antibiotic- ophthalmia neonatorum: and other are asymptomatic; complications in containing IV ceftriaxone antimicrobial eye men include gonococcal pyoderma, selective media 25–50 mg/kg SD drops; facilitates epididymitis, prostatitis, and seminal (Thayer-Martin HIV transmission vesiculitis; urethral colonization occurs medium); in 70%–90% of women infected with nonamplified gonorrhea; acute salpingitis and pelvic DNA probe test inflammatory disease occur in (hybridization 10%–20% of women; extragenital of gonococcal gonorrhea: oropharyngeal gonorrhea, RNA); nucleic rectal gonorrhea (anal intercourse), acid amplification gonorrheal ophthalmia (blindness); assays for disseminated gonococcal infection: chlamydial and arthritis-dermatitis syndrome, gonococcal gonococcal endocarditis, meningitis; infections ophthalmia neonatorum: inoculation during vaginal delivery, purulent conjunctivitis (continued) Copyright Cutis 2016. This page may be reproduced by dermatologists for noncommercial use. Disease Laboratory (Synonym[s]) Etiology Clinical Features Diagnosis Treatment Other Features Chancroid Haemophilus Incubation period: 3–7 d; erythematous Small Oral azithromycin 1 g SD; Prevalent in (soft chancre, ducreyi papule, pustule, and then painful ulcer gram-negative IM ceftriaxone 250 mg SD; promiscuous ulcus molle) on the internal and/or external surface bacilli (school oral ciprofloxacin 500 mg high-risk groups; of the prepuce, coronal sulcus, or of fish pattern); twice daily for 3 d; oral enhances HIV around the frenulum in men; introital isolation in culture erythromycin base transmission; and/or perianal area or on the cervix or (not available 500 mg 4 times daily for 7 d coinfection with vaginal wall in women; painful inguinal commercially) syphilis or herpes lymphadenitis, usually unilateral simplex virus is possible Congenital Treponema Marasmic syphilis, snuffles, perioral/ 19S antibodies on Aqueous crystalline penicillin G syphilis pallidum perianal fissures, lymphadenitis; late chromatography, 100,000–150,000 U/kg congenital syphilis: Hutchinson teeth, FTA-ABS 19S daily administered as interstitial keratitis IgM test, and 50,000 U/kg IV dose every IgM ELISA 12 h during the first 7 d of life and every 8 h thereafter for a total of 10 d; procaine penicillin G 50,000 U/kg IM in a single daily dose for 10 d Gonorrhea Neisseria Incubation period: 1–14 d; dysuria, Gram or Dual treatment with IM Preventive gonorrhoeae urethral purulent discharge; vaginal methylene blue ceftriaxone 250 mg SD and strategies for discharge, intermenstrual bleeding, staining oral azithromycin 1 g SD ophthalmia menorrhagia, and inflammation of the (gram-negative (recommended by CDC neonatorum Bartholin glands in women; primary diplococci in as first-line treatment); include topical site in women is the endocervical PMNs); culture: IM ceftriaxone 250 mg SD; silver nitrate canal; 10% of men and 50% of women antibiotic- ophthalmia neonatorum: and other are asymptomatic; complications in containing IV ceftriaxone antimicrobial eye men include gonococcal pyoderma, selective media 25–50 mg/kg SD drops; facilitates epididymitis, prostatitis, and seminal (Thayer-Martin HIV transmission vesiculitis; urethral colonization occurs medium); in 70%–90% of women infected with nonamplified ® gonorrhea; acute salpingitis and pelvicCutis DNA probeFast test Facts for Board Review inflammatory disease occur in (hybridization 10%–20% of women; extragenital of gonococcal gonorrhea: oropharyngeal gonorrhea, RNA); nucleic rectal gonorrhea (anal intercourse), acid amplification gonorrheal ophthalmia (blindness); assays for disseminated gonococcal infection: chlamydial and arthritis-dermatitis syndrome, gonococcal gonococcal endocarditis, meningitis; infections ophthalmia neonatorum: inoculation during vaginal delivery, purulent conjunctivitis Disease Laboratory (Synonym[s]) Etiology Clinical Features Diagnosis Treatment Other Features Granuloma Calymmatobacterium Incubation period: 1–4 wk after Donovan bodies Oral azithromycin Differential inguinale granulomatis exposure but symptoms may be on Giemsa, 1 g once weekly or diagnosis includes (donovanosis, delayed for 3–6 mo; painless or mildly Wright, or 500 mg daily for at least 3 carcinoma, granuloma painful papules or nodules that may Leishman staining wk or until all lesions have amebiasis, venereum) bleed; extragenital lesions may be of tissue smears completely healed; alternative tuberculosis, present due to autoinoculation or from active treatments: oral TMP-SMX Crohn disease, dissemination on the skin, bones, lesions; there are 160/800 mg twice daily and pyoderma intra-abdominal, and/or oral cavities no serologic tests for 3 wk; oral doxycycline gangrenosum for diagnosis 100 mg twice daily for 3 wk; oral ciprofloxacin 750 mg twice daily for 3 wk; oral erythromycin base 500 mg 4 times daily for 3 wk Lymphogranuloma Chlamydia Incubation period: 3–30 d; primary Serologic Oral doxycycline 100 mg Differential venereum trachomatis stage: herpetiform lesion on the detection of 2 times daily for 3 wk; diagnosis includes (lymphogranuloma coronal sulcus in men or posterior antibodies against pregnant women: oral chancroid, inguinale, vaginal wall in women with serovars L1-L3 erythromycin base 500 mg lymphoma, Durand-Nicolas- lymphangitis, groove signa; secondary of C trachomatis, 4 times daily for 3 wk and catscratch Favre disease) stage: begins after 2–6 wk, inguinal detection DNA disease; facilitates syndrome, unilateral lymphadenopathy sequence specific HIV transmission with painful erythematous bubo to chlamydia that drains pus and has sinus serovars by PCR tracts; anogenital rectal syndrome: proctocolitis, hyperplasia of the intestinal and perirectal lymphatic tissue, incontinence (continued) Copyright Cutis 2016. This page may be reproduced by dermatologists for noncommercial use. Cutis® Fast Facts for Board Review (continued) Disease (Synonym[s]) Etiology Clinical Features Laboratory Diagnosis Treatment Other Features Syphilis (lues) T pallidum Early syphilis: incubation period, Primary stage: presence of Primary, Syphilis facilitates 21 d; primary stage: painless papule treponemes on dark field secondary, and HIV transmission; that ulcerates as a single indolent, round microscopy; anticardiolipin early latent stage: follow-up or oval, indurated ulcer; secondary antibodies can lead to IM penicillin G examinations are stage: hematogenous and lymphatic false-positive RPR test 2.4 million U SD; recommended dissemination; prodromal symptoms: and false-positive VDRL late latent and at 6 and low-grade fever, malaise, sore throat, test; antibodies to surface tertiary stage: 12 mo following adenopathy, weight loss, muscle aches, proteins to T pallidum in IM penicillin G treatment of headache; nonpruritic papulosquamous TPHA, MHA-TP, or 2.4 million U once early syphilis; late eruption, pink to violaceous to red- FTA-ABS; secondary weekly for 3 wk; syphilis should brown lesions; painless mucosal ulcers stage: presence of neurosyphilis: be evaluated to large gray plaques in genital areas; treponemes on dark IV crystalline once every condyloma lata in the anogenital region, field microscopy, penicillin G 3 years; for CSF lymph node enlargement, nonscarring spirochetes detected 24 million U/d abnormalities,
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