Serve New Cleveland Clinic Ceo and President Tom Mihaljevic, Md Page 2

PHILANTHROPY SPARKS INNOVATION | SUMMER 2018

HERE TOSERVE NEW CLEVELAND CLINIC CEO AND PRESIDENT TOM MIHALJEVIC, MD PAGE 2

INSIDE: PYRAMID ESTABLISHING A CHARITABLE GIFT ANNUITY

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Service and Trust Spanning Four Decades GIFT FROM THE JONES DAY FOUNDATION HONORS THE FIRM’S LONGTIME RELATIONSHIP WITH CLEVELAND CLINIC

In 2017, Jones Day Foundation made a $3 million lead gift supporting Cleveland Clinic Children’s new outpatient facility, scheduled to open this fall. The gift arose from “an incredibly special” relationship between the global law ﬁ rm of Jones Day and Cleveland Clinic, says Christopher Kelly, a partner at Jones Day. That relationship spans four decades and includes the service of previous and current Managing Partners of Jones Day on Cleveland Clinic’s Board of Trustees. “In addition to advising Cleveland Clinic, our work together recognizes the importance of investing in the communities where we practice and the critical roles we play as active and engaged citizens in the places we operate,” Mr. Kelly says. “We are extraordinarily proud of the Foundation’s grant to Cleveland Clinic Children’s.” The Jones Day Foundation is independent and supported by the law ﬁ rm, Mr. Kelly says. “The Foundation exists as part of the core DNA of what Jones Day is as an institution. Through this grant from the Foundation, we are able to help advance Cleveland Clinic’s innovative world-class care for children Christopher Kelly and their families.” of Jones Day Cleveland is the birthplace of both Jones Day and Cleveland Clinic, Mr. Kelly notes. “We take special pride in being a part of the growth of cutting- edge capabilities the city has to offer. We are fortunate to be able to support such important initiatives and excited to see the vision of Cleveland Clinic Children’s become a reality.”

Back row, from left: Umberto P. Fedeli, Chris Kelly, Dr. Toby Cosgrove, Dr. Rita Pappas, Edward Jack Ross, Steven M. Ross. Front row, from left: Julius Chamoun, Jane Finley, Maisie Nowlin, Jack Thompson.

visit powerofeveryone.org to learn more TOP: PHOTO COURTESY OF JONES DAY. BOTTOM: PHOTO BY TOM HERCE TOM BY PHOTO BOTTOM: DAY. JONES OF COURTESY PHOTO TOP:

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New02 CEO The04 Power of Every One – Game16 Innovation17 and President Philanthropy at Work Changer

■ Tom Mihaljevic, Midway through the Power of Every One ■ At the Rose Ella ■ Promising research MD, outlines his campaign, read about: Burkhardt Brain may help give people vision and discusses ■ Sam Miller, one of Cleveland Clinic’s Tumor and with spinal cord injuries what led him to his best advocates. Neuro-Oncology the freedom to bike in new role. ■ Trina Bediako and her family’s support Center, new ﬁ ndings the great outdoors. of women’s health and cardiac rehab. are helping researchers ■ Mary Schaff’s gift advancing better understand the sleep apnea awareness. growth and spread ■ The legacy of Chris Crain, MD, of glioblastoma and his mother, Pearl Crain. tumors. ■ Howard and Margery Ternes’ gift to education at Cleveland Clinic Florida. ■ Ron and Mary Shortridge’s support of organ preservation for transplants. ■ The impact of a gift in shaping the future of medicine. ■ The 10th annual Florida Ball. ■ The Lerner School’s 10th year of life-changing education for students with autism.

ON THE COVER: Tom Mihaljevic, MD. Photo by Russell Lee Photography. Above left: Patient Ethan Bradley. Photo courtesy of the Bradley family. Middle: Doug and Linda Cowan host the annual liver transplant golf outing. Right: VeloSano Trike & Bike event. Photo courtesy of Cleveland Clinic.

Catalyst_SU18_01_TOC.indd 1 5/23/18 1:12 PM TOGETHER, WE’LL REACH ‘THE NEXT LEVEL OF GREATNESS’

om Mihaljevic, MD, became CEO and President of Cleveland Clinic on Jan.1. He succeeded Toby Cosgrove, MD, who served as CEO and President from 2004 to 2017, and who is staying on at Cleveland Clinic as Executive Advisor. From 2014 to 2017, Dr. Mihaljevic served as CEO of Cleveland Clinic Abu Dhabi (CCAD), where he previously was Chief of Staff and Chair of the Heart & Vascular Institute. Born in Croatia, Dr. Mihaljevic earned his medical degree from the University of Zagreb, trained at University Hospital in Zurich, Switzerland, and “THIS ORGANIZATION IS Tworked at Brigham and Women’s Hospital in Boston, MORE THAN BUILDINGS AND Massachusetts. In 2004, he came to Cleveland Clinic as a surgeon in the Department of Thoracic and PEOPLE. IT’S A LIVING IDEA. Cardiovascular Surgery. MY JOB IS TO ENHANCE On Feb.28, 2018, Dr. Mihaljevic gave his first AND PRESERVE THAT IDEA.” State of the Clinic address, outlining his vision for

Cleveland Clinic. TOM MIHALJEVIC, MD “Our course is clear,” he said. “Cleveland Clinic will be the best place for healthcare delivery in the world, and the best place to work in healthcare.”

PERSONAL STORY A quintessential team player, Dr. Mihaljevic likes to focus on the “we” rather than the “I.” But a few weeks before the State of the Clinic, he took a few minutes to share his personal story. “My mother was a teacher. She is a wise woman, and I still talk to her almost every day. My father was a middle manager in business. We lived with my younger sister in a one-bedroom apartment in Zagreb. Our life was modest but comfortable. Every day, I went out to buy the groceries: half a loaf of bread, a quarter gallon of milk and 100 grams of salami.” Croatia was then part of communist Yugoslavia. Although Dr. Mihaljevic had the support of a large extended family, his opportunities were limited by his parents’ known opposition to the regime. When he graduated from medical school at Zagreb

University in 1989, the Yugoslav federation was LEE RUSSELL BY PHOTO

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STEVE SZILAGYI

— SUMMER 2018 SUMMER

“We were healthcare diplomats,” he says, “bringing were healthcare “We Cosgrove announced his intention to When Dr. and “This organization is more than buildings • How would you treat this patient if they were a • How would you treat the resources of Cleveland True to his belief in teamwork, he concluded, “We But he was being actively recruited by Toby recruited by Toby But he was being actively that Cleveland Clinic was the “I had a gut feeling Cosgrove what was rst hired, he asked Dr. When fi Mihaljevic excelled in all types of cardiac Dr. HEALTHCARE DIPLOMAT HEALTHCARE QUESTIONS TOUCHSTONE RAPID PROGRESS RAPID He was ready for a new challenge in 2011 when Dr. when Dr. He was ready for a new challenge in 2011 of Cleveland Cosgrove—by then CEO and President go to Abu Clinic—offered him the opportunity to Mihaljevic led a highly motivated Dhabi. There, Dr. a concept international team that took CCAD from and construction site to becoming the leading specialty medical center in the Middle East. country.” American medicine to a new and dynamic Mihaljevic was transition out of the role of CEO, Dr. for the unanimous choice of the Board of Directors the position. Mihaljevic says. “It’s a living idea. My job is people,” Dr. to preserve and enhance that idea.” The new CEO’s State of the Clinic address was delivered before 800 guests and caregivers in the Ballroom of the InterContinental Hotel, and streamed Mihaljevic to thousands more around the world. Dr. asked his audience to consider two questions that are the touchstones of his administration: member of your own family? Clinic if this were your home? are going to build a plan for Cleveland Clinic that will will and input. It will be our plan. We ect your ideas refl Our generation will raise Cleveland do this together. Clinic to the next level of greatness.” Dr. Mihaljevic made quick progress at Brigham at Brigham made quick progress Mihaljevic Dr. and attending surgeon becoming an and Women’s, of surgery at Harvard School of assistant professor of work, and the potential to Medicine. With a lot Dr. Cohn as Chair of the department, replace Dr. very happy in Boston. Mihaljevic recalls being Chair of Thoracic and Cosgrove, MD, then at Cleveland Clinic. Cardiovascular Surgery Dr. Mihaljevic says. He accepted place to be,” Dr. and was quickly impressed Cosgrove’s offer in 2004, of heart surgeries by the volume and complexity in his new job. considered routine Cosgrove Dr. expected of him. “Do whatever you want,” said, “but be the best in the world at it.” leadingworld’s the of one become to on went and surgery surgery,practitioners of robotically assisted cardiac technique. publishing pioneering papers on the new POWEROFEVERYONE.ORG Forced to seek further training abroad, he gave training abroad, to seek further Forced by Marko Turina,In Zurich, he was mentored Cohn’s Mihaljevic was accepted to Dr. Dr. beginning to dissolve—with civil war in the air. to dissolve—with civil beginning in German crash course himself a three-month at University Hospital in to earn an assistantship modern German authors,” Zurich. “I still enjoy Mihaljevic, a self-described bookworm. says Dr. and Croatian exile. Dr. MD, a cardiac surgeon Mihaljevic toward cardiac Turina steered Dr. linked him up withsurgery, and eventually head of the Department ofLawrence Cohn, MD, Hospital. and Women’s Cardiac Surgery at Brigham ve of 600 applicants for only fi training program, one “I was lled with uncertainty. he was fi positions. Yet torst non-American in the program.” He had the fi in Croatia.turn down a solid job offer from a relative “I didn’t know what I was getting into.”

PHOTO CREDIT TK Catalyst_SU18_02-03_DrMihaljevic.indd 3

TOGETHER, REACH WE’LL ‘THE NEXT LEVEL OF GREATNESS’ OF LEVEL NEXT ‘THE philanthropy at work

OUR SHARED FOCUS IS ON THE FUTURE AND ON THE POWER OF EVERY GIFT.

EACH ONE OF YOU MAKES A HUGE DIFFERENCE TO CLEVELAND CLINIC.

WE THANK YOU FOR ALL THAT YOU DO.

alfway through the Power of Every One For that, we are relying on each of you whose pas- campaign, your gifts already have made a signif- sion and generosity are advancing patient care, icant impact on Cleveland Clinic. In this issue, research and medical education. we’ve dedicated a special section to highlighting Thank you for joining us at annual events, examples of gifts that are helping our caregivers including major celebrations such as the save and improve the lives of patients here Children’s Gala, the Power of Love® gala and the and around the world. VeloSano bike event, and also our smaller, more We’re grateful to Toby Cosgrove, MD, for his bril- intimate gatherings leading up to them. liant and steadfast leadership, which inspired over Our shared focus is on the future and on the $50 million in gifts to the Cosgrove Transformation power of every gift. Each one of you makes a huge HFund. And we’re excited to continue the campaign difference to Cleveland Clinic. We appreciate all under Tom Mihaljevic, MD, who became Cleveland that you do and look forward to working with you Clinic’s new CEO and President on Jan. 1. in the days and months ahead. Knowing that we can’t rest on our laurels, we will continue working toward our $2 billion goal. Thank you,

Centennial Campaign Commitments (Goal: $2 Billion)

$1.3b $1 billion $983m $876m $800m $741m $711m $686m $637m $600m

Larry Pollock Stewart Kohl Campaign Co-Chair Campaign Co-Chair

Jun. Sep. Dec. Mar. Jun. Sep. Feb. Sep. June 2014 2014 2014 2015 2015 2015 2016 2016 2018

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BOARD SPOTLIGHT: SAM MILLER Decades of Sam Miller and Service and Dr. Toby Cosgrove Support

“No act of kindness, no matter how small, is wasted,” Sam Miller was quoted as saying in a 2003 interview with Smart Business Cleveland. “When you do a good thing, it comes back to you.” For nearly 30 years, Mr. Miller has been doing good things as one of Cleveland Clinic’s best advocates, giving generously of his time and resources to dozens of projects and specialty areas. In addition, he has encour- aged many others to do likewise. “Many decades ago, Sam Miller met and fell in love ing Dr. Floyd Loop. The rest is history — Sam has been with Cleveland Clinic,” says attorney and longtime instrumental as a Board member and donor in help- friend Robert Duvin. “In the very early period of Sam’s ing Cleveland Clinic become the national and interna- relationship with Cleveland Clinic, every Sunday tional iconic healthcare institution that it is today.” morning for approximately two years, he person- On the Board of Directors, Mr. Miller has drawn on TOP: PHOTOS COURTESY OF CLEVELAND CLINIC. BOTTOM: PHOTO BY DON GERDA.. ally delivered hot bagels to several doctors, includ- his vast business expertise to help guide Cleveland Clinic’s growth and development, working with leaders Floyd D. Loop, MD, and Toby Cosgrove, MD. Through the years, his philanthropic gifts have advanced cancer research and treatment, wellness initiatives, leading-edge brain research, nursing care and professional excellence. As top supporters, Sam and Maria Miller were inducted into the 1921 Society and both received Cleveland Clinic’s highest honor, Distinguished Fellow, for extraordinary contributions and service. Beyond his personal philanthropic support are the many gifts made to Cleveland Clinic by numer - ous individuals and organizations with whom he has built relationships. A graduate of Case Western Reserve University with an MBA from Harvard Business School, Mr. Miller has a long history of active engagement in the Cleveland community. His substantial contributions to Cleveland Clinic, both as benefactor and volunteer, are helping to secure its place as a leader in shaping the future of medicine. Dr. Floyd Loop and Sam Miller —ELAINE DEROSA LEA

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When her mother died of a heart Trina Bediako cardiac rehabilitation. The app attack in 2014, Trina Bediako’s project is headed by Leslie Cho, world was shattered. Only three MD, Director of Cleveland Clinic’s weeks earlier, her parents, Jonnie Women’s Cardiovascular Center and Tilmon Brown, had returned and holder of The Karos from a cruise celebrating their 50th Family Term Chair in Women’s wedding anniversary. Cardiovascular Research. “We were blessed, and our “People with heart disease, business was thriving,” says Mrs. those who have had bypass or stent Bediako, President of New Horizons surgery, or a heart attack, would Baking Company in Norwalk, Ohio. live longer if they participated It was this good fortune that led her in a cardiac rehab program,” Dr. parents to establish the T. & J. Brown Cho says. “Yet, these are the most Family Fund in 2003, which supports underutilized programs—only programs that serve the community. 30 percent go for rehabilitation When her mother passed away, after open heart surgery, and only Mrs. Bediako became a fund trustee. 15 percent after a heart attack or In that role, she helps her family stent. Usually, it requires going to define their philanthropic priorities. a hospital three times a week for She says that her intention is three months. This is why we are to honor her mother’s memory developing an app that people can while addressing the needs of the get for free and that will allow them community. to do their rehab at home.” For her, and for her family, “I thank Trina for supporting According to the American Heart Mrs. Bediako says, “philanthropy is Celebrate Sisterhood,” says Linda Association, cardiac rehabilitation about so much more than writing a Bradley, MD, the event’s founder reduces deaths by 28 percent, as well check.” It means volunteering and and Chair, a gynecologist and Vice as reducing recurrent heart attacks being passionate about what they Chair of Cleveland Clinic’s Ob/Gyn & and symptoms, and lowering blood support. Recently, she, her sister and Women’s Health Institute. pressure and cholesterol. nieces volunteered for a community “These dollars are precious, and In addition to the app, the gift will fitness challenge at Cleveland Clinic we appreciate the gift and will use it be used to help raise awareness about Langston Hughes Community responsibly for activities to educate, heart disease in women, Dr. Cho says. Health and Education Center. empower and help women be “I’m truly grateful for this gift,” “We had a wonderful time,” she effective leaders in our community,” Dr. Cho says. “We have an incredible says. “We need centers like Langston Dr. Bradley says. “The return on need for cardiac rehab that is not Hughes in the community. The investment of this significant being met. The national Centers for people who came through those contribution multiplies because when Disease Control and Prevention has doors were so comfortable in that women attend our event, they leave made increasing the use of cardiac space. There is camaraderie and better educated and empowered.” rehab one of its goals for 2020.” competitiveness, as in the fitness The 15th Celebrate Sisterhood, Mrs. Bediako says she, her challenge. We look forward to doing featuring speaker panels, husband, Gabriel, and all more in the future.” workshops, activities, and health generations of her family are happy In 2017, the family committed and lifestyle exhibitors, is planned to be making a difference in the to making a $1 million gift to the for Oct. 20 at Executive Caterers at community. Cosgrove Transformation Fund at Landerhaven in Cleveland. For “We believe that to whom much is Cleveland Clinic. A portion of the gift more information, please go to given, much is required,” she says. supports Celebrate Sisterhood, an clevelandclinic.org/celebratesisterhood. “We believe that we are responsible annual multicultural women’s health The family’s gift also is advancing for helping others.”

and wellness event. development of a mobile app for —ELAINE DEROSA LEA PHOTOGRAPHY MOLL MOLL, DARRELL BY PHOTO

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Catalyst_SU18_04-09_PhilanthropyAtWork.indd 6 5/17/18 10:52 AM philanthropy at work Gift Furthers Awareness of Sleep Apnea Sleep apnea is a serious medical Sleep apnea was among the John and Mary Schaff condition, associated with heart conditions listed as a cause of death disease, stroke and Alzheimer’s. Mary on his death certificate. Schaff of Michigan knows this ﬁ rsthand. “I realize that the test, itself, may not Her husband, John, passed away at age have saved his life, but it would have 57 due to complications associated been a start,” Mrs. Schaff says. with sleep apnea. Coincidentally, after her husband’s “The only thing worse than losing death, she also was diagnosed with John is knowing that had he been sleep apnea. diagnosed sooner and gotten the help he The sleep app being developed needed, his death likely could have been at Cleveland Clinic allows easy prevented,” she says. screening for disorders such as apnea,

TOP: PHOTO COURTESY OF MRS. SCHAFF. BOTTOM: PHOTO BY TOM MERCE, CLEVELAND CLINC PHOTOGRAPHY. To help prevent others from having a Dr. Foldvary-Schaefer says. “It includes similar experience, Mrs. Schaff made a a formula to estimate one’s probability transformational planned gift supporting of having signifi cant sleep apnea and development of a mobile sleep app by and stopped using it. He never had it will then assist the user in fi nding Nancy Foldvary-Schaefer, DO, MS, and calibrated by a trained technician. local accredited sleep services. It also her team at Cleveland Clinic’s Sleep Looking back, Mrs. Schaff remembers provides education on relevant topics Disorders Center. The gift also advances that her husband had trouble staying based on the individual’s sleep disorder patient and caregiver education. awake during the day. He fell asleep in profi le — we screen for sleep apnea, Prevention includes recognizing the church, while watching TV and at his insomnia, shift work disorder and signs of sleep apnea, which can include desk in the offi ce. Once, she saw him insuffi cient sleep.” snoring, Mrs. Schaff says. With sleep start to doze while driving, and then she The gift also allows Dr. Foldvary- apnea, breathing repeatedly starts and became the primary driver. Schaefer and her team to pursue stops, preventing high-quality sleep, “In retrospect, that alone should have educational efforts for both the public affecting concentration and leading to been an enormous red flag,” she says. and medical providers that will help other problems including high blood “But all of these things were incremental raise awareness about sleep apnea. pressure, impotence, depression, and simply annoying, so we carried on.” “Mary’s gift is allowing us to convert weight gain and diabetes. Eventually, an internist diagnosed concepts into reality that have the Her husband began snoring when sleep apnea, and Mr. Schaff agreed he potential to impact millions of people he was in his early 40s, but for years, he would try to get his condition under around the world,” Dr. Foldvary-Schaefer refused to believe that anything was control. A sleep test was set up, but says. “She has been an ideal partner in wrong, she says. He would not agree the earliest available appointment was supporting our program’s development to an in-clinic sleep test because his several weeks out. and initiatives and in providing personal friends said it would be uncomfortable. Unfortunately, only two days before insights and ideas for enhancement He tried a CPAP (continuous positive his scheduled test, Mr. Schaff had from the patient’s perspective. airway pressure) machine that he tachycardia, a dangerously fast heart I am honored to have the awesome ordered from the internet, but after a rate. He was stabilized, but shortly opportunity to partner with her.” few nights decided it wasn’t working thereafter, he died of cardiac arrest. —TERRI ZUPANCIC Mother and Son Leave a Legacy of Service Lawrence “Chris” Crain, MD, had for an aunt who had kidney disease led several firsts at Cleveland Clinic: He him to specialize in nephrology. drew his first breath when he was born After completing his training at there on May 17, 1965. A congenital heart Cleveland Clinic, Dr. Crain joined South defect led to his first surgery there. And, West Nephrology in Atlanta, Georgia. He in 1997, he became Cleveland Clinic’s missed being involved in academics, so first African-American Chief Medical he later joined Emory University. He lived Pearl Crain and her Resident in internal medicine. in Atlanta with his wife, Lilly, and son, daughter-in-law, The challenges of heart disease inspired Jose, until July 22, 2003, when he passed Lilly Crain him to become a doctor, and his concern (continued on page 8)

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(continued from page 7) away unexpectedly at the age of 38. “He cared deeply about each patient,” Lilly Crain says. “He was very passionate regarding giving back to the community, as was his mom. When he died, I realized the magnitude of the effect he had, how many lives he touched, because of the number of people who attended his funeral—there were hundreds.” A few weeks later, his father, Lawrence Crain, also passed away, leaving his mother, Pearl Crain, bereft of both her husband of 45 years and her only child. Afterward, Pearl Crain devoted herself to the Lawrence “Chris” Crain Memorial Lecture Fund, as well as volunteering at Cleveland Clinic, for which she was named Volunteer of the Year in 2006. She, along with Bryon Hoogwerf, MD, Dr. Crain’s former Internal Medicine Program Director, established the fund. It supports a yearly lecture by a prominent physician focusing on the topics about which Dr. Crain was most passionate: healthcare disparities, hypertension, and kidney and heart disease.

Her efforts, along with those of Lilly Crain, family friend Howard and Margery Ternes Georgia State Sen. Emanuel Jones, and Cleveland Clinic physicians Joseph Nally, MD, and Craig Nielsen, MD, FACP, fueled the success of the lecture series, now in its 15th year. In addition, starting this year, the fund supports Generous Gifts Advance an award in Dr. Crain’s name that goes to a Lerner College of Medicine student. Medical Education Pearl Crain continued her work to advance the fund until she passed away on Jan. 19, 2018, at the age of 89. At her For Howard Ternes of Jupiter, Florida, funeral, she was remembered for her own firsts: The first open heart surgery at Cleveland Clinic Florida woman to serve as a Cleveland City Project Director in 1987 was so successful that he and his wife, Margery, and the first African-American woman appointed director have made gifts totaling more than $750,000 of a major governmental department in the city. She also supporting medical education there. served on multiple boards, developed community programs Their philanthropic support is especially and organized events. signiﬁcant because it addresses the acute “If she made up her mind to do something, it was going shortage of medical school training positions to get done,” Lilly Crain says. throughout the United States. Dr. Nally and Dr. Nielsen concur. “It was no surprise to This shortage is due to funding cuts that me that when the idea was floated about a program devoted were made 20 years ago to medical specialty to Chris’ legacy, Pearl was totally committed to it,” says training programs. As a result, there’s a Dr. Nally, who not only was Chris Crain’s mentor during shortage of skilled specialists at a time when his residency at Cleveland Clinic, but also Lawrence there is greater need for their services. Crain’s physician. “Demands for medical specialists are “A lot of the success of the program was due to Pearl, rising dramatically, and yet, signiﬁcant who was a driving force,” he says. “She was such a gracious resources and many years of education are individual and so proud of her family, and she was a mother required to produce one medical specialist,” to all. She viewed us as extended family.” says Cleveland Clinic Florida President PHOTO COURTESY OF CLEVELAND CLINIC Pearl Crain helped ensure that the fundraising goal for Wael Barsoum, MD, who holds The Robert the program was met. “It was her outreach to family, friends and Suzanne Tomsich Distinguished Chair and colleagues of Chris that helped move this forward,” Dr. in Healthcare Innovation. He expressed Nielsen says. He also has fond memories of Dr. Crain, who gratitude for the Ternes’ generous support was a year ahead of him in the residency program. of crucial medical education. “Chris was an excellent resident and Chief Resident, very “In 2014, the youngest baby boomers in no-nonsense,” he says. “He also had a soft personal side, the United States turned 50, bringing the when you got to know him. When he said something, you number of adults over age 50 to 100 million,” listened because you knew it was going to be worthwhile.” Dr. Barsoum says. “A greater number of older

—ELAINE DEROSA LEA Americans means there is a greater demand FLORIDA CLINIC CLEVELAND OF COURTESY PHOTO

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for specialists to treat diseases commonly seen in older patients, including heart disease.” Couple’s Gi Supports a New Robert Cubeddu, MD, Cleveland Clinic Florida Director of Cardiology, Approach to Organ Transplants notes that heart and vascular research and education are critical to It was the summer of 2013, and forget what happened one day in early understanding the underlying causes Ron Shortridge was desperately seeking March 2014. “My wife was next to me, of heart disease and to developing a diagnosis. He and his wife, Mary, holding my hand, when her phone new treatments and cures. crossed the country to consult with rang,” he says. “All she kept saying was, “Education also is essential for training hospitals and specialists, but no one ‘Praise God!’ She said it several times. the next generation of cardiovascular could give them an answer. It didn’t take long for me to ﬁgure out specialists,” Dr. Cubeddu says. His symptoms included extreme they’d found a match for me.” “Cleveland Clinic Florida is immensely fatigue, abdominal pain and cognitive Transplant surgeons Cristiano grateful for the generosity of Howard impairment, and he was always cold. By Quintini, MD, Director of Liver and Margery Ternes and other October, he was too sick to work or drive. Transplantation at Cleveland Clinic, and supporters who are ensuring that our Soon, he didn’t have the strength to walk Masato Fujiki, MD, began the eight-hour program is thriving in these key areas.” and was bedridden. “Mary and I both operation at 3:30 a.m. on March 8—a day The couple was moved to support thought I was dying,” Ron says. Ron now calls his “re-birthday.” the program after Mr. Ternes’ stellar Mary wasn’t giving up, though. A He spent a month in the hospital experience in 2010 at Cleveland Clinic friend’s brother who is a physician recovering. Dr. Quintini, who provided Florida in Weston. “From an impressive looked at the medical ﬁles she compiled Ron’s follow-up care, told him about his

Howard and Margery Ternes ICU to the superb team of medical and concluded that there was a problem research into ex vivo organ perfusion, a caregivers to the staff who cleaned the with Ron’s liver. He recommended the revolutionary technology that is changing rooms, they were all friendly, attentive Digestive Disease & Surgery Institute at how donor organs are preserved. He and and professional,” he says. Cleveland Clinic. Ron and Mary met with his team built a perfusion machine, a Mr. Ternes had heart bypass and William Carey, MD, MACG, of Cleveland portable ICU that preserves organs better stent surgeries at a hospital near his Clinic’s Department of Gastroenterology, than standard methods and also revives Jupiter home, and when he continued in late December. Ron says that within 15 organs that are less than perfect, making to have heart problems a few years minutes, Dr. Carey diagnosed him with them usable for transplant. later, he was referred to Howard Bush, alpha-1 antitrypsin deficiency, a rare, Ron and Mary’s belief in Dr. Quintini’s MD, an interventional cardiologist at potentially fatal genetic disorder. Low work led them to make a gift supporting Cleveland Clinic Florida. After an initial levels of alpha-1, a protein made within his research. They also became meeting and medical review, Dr. Bush liver cells, affect the lungs. Occasionally, advocates of organ donation and the ex conferred with his colleague Edward the damage leads to scarring and vivo organ perfusion technique. Savage, MD, a Cleveland Clinic Florida complications of cirrhosis. “This has to be one of the top cardiothoracic surgeon. Together, Dr. By the time the disease was medical philanthropic projects you Bush and Dr. Savage decided that Mr. diagnosed, Ron’s liver was barely could support,” Ron says. “It’s not one Ternes should have open heart surgery. functioning. Testing showed that he was that could possibly save lives when a “We were so impressed by what a good candidate for a liver transplant, cure is developed years from now—it we saw and particularly in light of my and he returned home to wait. In can save lives right now.” previous heart surgery,” Mr. Ternes February 2014, he came to Cleveland —JILL STEFANCIN says. “Because we understand that Clinic for additional testing there is a grave shortage of physicians, but was admitted to the we feel that continued training of our hospital because he was so future heart leaders at Cleveland Clinic ill. He and Mary realized that Florida is important.” if he did not receive a liver Mrs. Ternes agrees. “The doctors are soon, he would die. PHOTO COURTESY OF CLEVELAND CLINIC so passionate about educating those He became a priority who serve in the medical field,” she patient on the national says. “After speaking with Dr. Bush and transplant waiting list. By Dr. Savage, we understood that one of then, his kidneys had shut the reasons they wanted to practice at down, and he was on daily a teaching hospital is that they would dialysis. Ron says he’ll never always have the opportunity to teach and learn from the young physicians seeking specialized training in the Ron and Mary Shortridge, center, with, from left: Daniele Pezzati, heart and vascular field.” MD, Cristiano Quintini, MD, Qiang

PHOTO COURTESY OF CLEVELAND CLINIC FLORIDA CLINIC CLEVELAND OF COURTESY PHOTO —ELAINE DEROSA LEA Liu, MD, and Ahmed Hassan, MD.

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THE IMPACT OF GIVING HOW YOUR PHILANTHROPY SHAPES THE FUTURE OF MEDICINE

BY KATHRYN DELONG AND ELAINE DEROSA LEA Cleveland Clinic’s Lerner Research Institute (LRI), received funding via VeloSano’s granting process twice, in 2014 and 2016. t Cleveland Clinic, every gift matters. The stories that follow Dr. Sharifi , who holds the Kendrick show how philanthropy is paving the way for groundbreaking patient Family Chair in Prostate Cancer Research, care and research. These are only a sampling of what has been co-directs LRI’s Center of Excellence in achieved with the help of forward-thinking supporters: 3-D heart tech- Prostate Cancer Research with Eric Klein, nology for children and adults; advances in prostate cancer research; MD, Chair of the Glickman Urological & lives saved in the nick of time by a Mobile Stroke Treatment Unit; Kidney Institute and holder of the Andrew C. medical students who are achieving their dreams with the help of a Novick, MD, Distinguished Chair in Urology. foundation that cares about their future and the future of healthcare. The Center is seeking ways of These stories exemplify innovation and progress sparked by distinguishing lethal forms of prostate generosity, and what is possible when people who care join with cancer from those that can be treated caregivers to shape the future of medicine. effectively. Serpil Erzurum, MD, Chair of LRI, who holds The Alfred Lerner Gifts Support Prostate Cancer Research Memorial Chair in Innovative Biomedical With funds raised by VeloSano, a year-round initiative, Nima Sharifi , Research, notes that the Center’s catalytic AMD, and his team are making great strides in prostate cancer research. work couldn’t have been done without Dr. Sharifi , a staff researcher in the Department of Cancer Biology at philanthropic support. Thanks to early detection, prostate cancer is, in many instances, a curable disease. Yet, according to the American Cancer Society, it is the third leading cause of cancer deaths in American men, after lung and colorectal cancer. One approach Dr. Sharifi ’s team is studying is androgen deprivation therapy (ADT). “Think of testosterone as fuel,” Dr. Klein says. “ADT prevents the body from producing fuel—it’s like emptying the gas tank in a car, so initially, the cancer can’t go anywhere. As cancer progresses, however, it develops the capacity to grow on the few remaining drops of fuel left in the tank. The tumor might be dormant for a year or two, but then it returns—it outsmarts therapy that way.” Drs. Klein and Sharifi are pursuing answers to this problem by studying genomics. “What’s the DNA doing to that person’s tumor? That’s the main driver for our research,” Dr. Klein says. “Are some people born predisposed to aggressive prostate Nima Sharifi , MD, Co-Director of the Lerner cancer? If that’s the case, we need to learn Research Institute’s Center of Excellence to recognize them so we will see better in Prostate Cancer Research. outcomes when they’re treated.” PHOTOGRAPHY CLINIC CLEVELAND BAEHR, KEN BY PHOTO

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Latin for “swift cure,” VeloSano is a year- round fundraising initiative with the Philanthropy Furthers Training of Diverse Student Body mission to advance lifesaving cancer Every year, the White Coat Ceremony tops off orientation week for research at Cleveland Clinic. All of the new medical students at Cleveland Clinic Lerner College of Medicine. money raised through VeloSano directly During the ceremony last July, members of the Class of 2022 read supports the cause. In just four years, aloud an Oath of Professionalism, which they wrote. more than $12.5 million is hard at work “We will address disparities in care,” they said. “We stand as lifelong against cancer. (See related story on students, educators and advocates for all people.” page 13.) The new medical students concluded with these inspiring and humble words: “To our patients, we seek to empower you, partner with you and respect your dignity. We will provide care beyond treatment for illness and disease. We are grateful for the honor and privilege to serve you.” TOTAL CONTRIBUTIONS Two of this year’s class members, Joan Nambuba and Daniel Santana, are recipients of the KeyBank Minority Medical Student Scholarship. Here are short bios of Joan and Daniel and an introduction to the KeyBank Foundation’s program. Born in Kampala, Uganda, Joan moved to the United States with her family when she was 9. They settled in northern Virginia. Joan went on to receive her bachelor of science 12,623 in neuroscience, with minors in chemistry and English, from Duke University. As an 18,098 undergraduate, Joan was selected for the Duke Engage program as well as Resident 22,349 Joan Nambuba Assistantship. After college, Joan took two 25,776 gap years, during which she received the Postbaccalaureate Intramural Research Training Award, allowing her to conduct research at the National Institutes of Health. DOLLARS RAISED She then returned to her alma mater’s School of Medicine to obtain a master’s degree in biomedical sciences. During that time, Joan became a semiﬁnalist for a Fulbright U.S. Student Program Research Award. Daniel, who is from Long Island, New York, graduated from Dartmouth College in 2016 with a bachelor of science in biomedical engineering with High Honors, PHOTOS BY REEN NEMETH, CLEVELAND CLINC PHOTOGRAPHY based on his commitment to biomedical Daniel Santana $1,958,356 research. In addition, he served as a teaching assistant, an on-campus emergency medical technician, a leader $3,000,000 of humanitarian engineering projects and a member of the Outing Club. He is passionate about the outdoors and loves to escape into the $3,377,456 wilderness, especially on a bike or snowboard. Dan enjoys hands-on projects and hopes to integrate many of his interests into his future $4,175.943 career as a physician and scientist. By eliminating many of the ﬁnancial barriers that aspiring physicians face, the KeyBank Minority Medical Student Scholarship enables promising students to pursue a medical career and PHOTO CREDIT TK change lives. Each year with KeyBank Foundation’s philanthropic 2014 2015 2016 2017 commitment, increasing numbers of minority students graduate from Cleveland Clinic Lerner College of Medicine. The college is able to leverage scholarship opportunities to actively recruit a diverse student body, one soundly prepared to lead the future of healthcare.

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Catalyst_SU18_10-12_Feature.indd 11 5/17/18 10:53 AM Catalyst_SU18_10-12_Feature.indd 12 12 CATALYST absolutely incredible.” running aroundandexploringwantstobeoutside,”Katrina says.“It’s better thanever,withoxygenlevelsheneverbeforehadachieved.“He’s surgical outcomes. also providedasignificantadvantageintheteam’sabilitytopredict of successfullyperformingtheprocedure.Using3-Dprintedmodel his heartmodelandmakeanincisioninit,confirmingthefeasibility require precisedetailofcomplexanatomyforprocedures. CT scans.Philanthropicsupporthelpedmakethesemodelsareality. developed 3-Dprintedheartmodelsbasedonpatients’cardiacMRIand Cardiology, incollaborationwiththeLernerResearch Institute,had and didaCTscan,whichM.Shazam Hussain,MD,readremotely. minutes later,ClevelandClinic’s MobileStrokeTreatmentUnitarrived collapsed. Shecrawledupstairs, andhersister-in-lawcalled911.About20 In August 2014, Linda Brown was doing laundry in her basement when she Mobile Stroke thatSaves Unit:AGift Lives technology intoourtreatmentsformanyfuturepatients.” “Expanding onhisaptitudewillhelpincreasethewaysweincorporate this about 3-Dprintingandhowitmaybeusedclinically,”Dr. Griffinadds. the besttreatmentapproaches,”Dr. Griffinsays. instrumental inexpandingourabilitytouse3-Dimaging envision the BoardExaminationinCardiovascularDiseaseandhas been understanding complexcardiacdiseasesandinjuries. researcher whoseinterestsincludeusing3-Dprintingtohelpin Serge Harb,MD,whospecializesinimagingandvalvedisease. Cardiovascular Medicinesupportedtheworkofgeneralcardiologyfellow patients alsoreceiveenhancedcarebecauseof3-Dtechnology. At theSydellandArnoldMillerFamily Heart&Vascular Institute,adult Endowed ChairYieldsEndlessPossibilities Ultimately, the surgery was executed exactly as planned. Ethan is doing Ultimately, thesurgerywasexecutedexactlyasplanned.Ethanisdoing Prior tothisinnovativesurgery,Ethan’ssurgicalteamwasablehold A 3-Dmodelisanexceptionaltool,particularlyforphysicianswho Fortunately, ClevelandClinicChildren’sDepartmentofPediatric Dr. Hussain,whoheadsthe strokeprogramatClevelandClinic’s “The BrownChairallowedustosendSergeacourselearn more “He receivedthehighestmarkseverachievedbyafellowon The chairholder,BrianGriffin,MD,saysthatDr. Harbisacreative Funding fromtheJohnandRosemary BrownEndowedChairin philanthropy atwork |

Bradley SUMMER 2018 Ethan C_ED_Mobile StrokeUnitVehicle_087087_07-16-14_YKL oxygen deficiency. of breathandtired.” run aroundandplaybecausehewouldbeout mother, Katrina Bradley. “Hewasn’tableto special backpack,allday,everyday,”sayshis of secondgradewearingoxygeninalittle back inthehospitalwithheartfailure. tubes. Itwasn’tlong,however,beforehewas hooked uptomonitors,oxygenandfeeding just 1monthold.Aftereachone,hewenthome throughout hisyounglife,startingwhenhewas heart disease,hadnumeroussurgeries Ethan Bradley,a10-year-oldwithcongenital Power of3-DPrinting Giving HelpsHarnessthe In July2016,Ethanexperiencedsevere This wentonforyears.“Ethanspentall

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M. SHAZAM HUSSAIN, MD “YOU LOSE NEARLY 2 MILLION other citiesallovertheworld.” the potentialtoimpactstroke treatment in was acatalyticgiftfromtheMaltzes. Ithas of theCerebrovascularCenter. “This really stroke,” says Peter Rasmussen, MD, Director gift byTamar andMiltonMaltz. of thefirstinnation,isresulta a situationwhereeveryminutecounts.” a stroke.Timeiscriticallyimportant.This nearly 2millionbraincellsaminuteduring severely affectedheroutcome.You lose delay,” Dr. Hussainsays.“Thiswouldhave to, onaverage,anadditionalthree-hour to aninterventionalcenter,whichleads she wouldhaveneededanothertransfer everything forherself. on herleftside.Today, shecandomost coordination problems,aswellweakness time inrehabilitationformovementand brain’s bloodvessels. her arteriesandremovingaclotfrom endovascular therapy,placingcathetersin her carotidartery,Dr. Hussainperformed blockage intwomajorbrainvesselsand hospital. Whenadditionaltestsrevealed took LindadirectlytoaClevelandClinic having aseverestroke,”Dr. Hussainsays. her intheMSTU,wecouldseethatshewas taken totheclosesthospital,butbyassessing clots) 32minutesafterLindaenteredtheunit. intravenous drugthatbreaksdownblood and themobileteamadministeredtPA (an Cerebrovascular Center,diagnosedastroke, MINUTE COUNTS.” DURING A STROKE. EVERY BRAIN CELLS A MINUTE “There is no better or faster way to treat “There isnobetterorfasterwaytotreat The MobileStrokeTreatmentUnit,one “If Lindahadgonetotheclosesthospital, After beingdischarged,Lindaspent They bypassedthenearestcenterand “Usually, apatientlikeLindawouldbe 087082_07-16-14_002_YKL.jpg 087082_07-16-14_017_YKL.jpg 087082_07-16-14_012_YKL.jpg 087082_07-16-14_007_YKL.jpg 5/17/18 10:53 AM ** NOSIGNEDRELEASE TOP: PHOTO COURTESY OF BRADLEY FAMILY. BOTTOM: PHOTO COURTESY OF CLEVELAND CLINIC. 087082_07-16-14_003_YKL.jpg 087082_07-16-14_008_YKL.jpg 087082_07-16-14_013_YKL.jpg 087082_07-16-14_018_YKL.jpg 087082_07-16-14_019_YKL.jpg 087082_07-16-14_014_YKL.jpg 087082_07-16-14_009_YKL.jpg 087082_07-16-14_004_YKL.jpg 087082_07-16-14_020_YKL.jpg 087082_07-16-14_015_YKL.jpg 087082_07-16-14_010_YKL.jpg 087082_07-16-14_005_YKL.jpg 1 philanthropy at work Florida Ball, “Majestic Seas,” Makes Waves The 10th annual Cleveland A highlight of the ball was the Clinic Florida Ball on Feb. 23 presentation of the 2018 Sydell L. at The Breakers Palm Beach, Miller Award to Jeff Levitetz and themed “Majestic Seas,” raised the Levitetz Family Foundation. $1.2 million. This year’s proceeds The award was established in 2011 support expanding cardiac to recognize benefactors who imaging services at the Tomsich have committed themselves to Health and Medical Center in Cleveland Clinic Florida’s mission West Palm Beach; enhancing of providing world-class care. research opportunities for young Mr. Levitetz, philanthropist and physicians in their first five longtime champion of Cleveland years of practice; and creating Clinic Florida, and the Levitetz a physical therapy suite in Palm Family Foundation recently Beach Gardens. made a multimillion-dollar gift Event organizers were Chairs From left: Tom Mihaljevic, MD, Jeff Levitetz, to Cleveland Clinic Florida’s Sydell L. Miller, Wael Barsoum, MD. Julie and Michael Connors and nationally ranked Orthopaedic Mary and Tom Gilbane, with Surgery Department. In Grand Honorary Chairwoman Sydell L. Miller. Also helping to appreciation of his significant contribution toward orthopaedic make the event a success were Honorary Chairwomen Mickey research and development, caregiver training and patient care Beyer, Diann Scaravilli and K.K. Sullivan; and Vice Chairwomen initiatives, Mr. Levitetz also was recognized at a recent event Linda Adelson, Paula Butler and Kathryn Vecellio. naming the Levitetz Department of Orthopaedic Surgery.

Communities Rally Around Events Show the VeloSano All Year Long Power of Every One VeloSano is a year-round fundraising Trike & Bike Benefiting VeloSano Kids Year-round community events are vital initiative to advance lifesaving cancer Trike & Bike is a new community to the Power of Every One campaign. In research at Cleveland Clinic. The initiative benefiting VeloSano Kids. 2017, 85 events raised over $1.5 million flagship event, the “Bike to cure” Riders ages 3–12 participate in a for Cleveland Clinic research and patient weekend, takes place each July and bike ride, with all proceeds directly care, and nearly 30 are planned so far draws thousands of physical and virtual supporting lifesaving pediatric cancer this year by community members part- riders. This year, that event is planned research at Cleveland Clinic Children’s. nering with Cleveland Clinic. Every dollar for July 20–22. Trike & Bike events will take place in raised goes to the programs supported Since VeloSano began four years ago, several local communities. For more by these events. over $12.5 million has been raised, 100 information, please visit giving.ccf.org/ New this year is an initiative called percent of which goes to the cause. trikeandbike or contact Adam Gundlah Kids Give Back, which provides tools Following are some of the new community at [email protected]. and resources to school-aged chil- events supporting this initiative: dren in the community who are inter- St. Rita School Fundraiser ested in hosting events that will benefit Thanks to the National Junior Honor Cleveland Clinic Children’s. Society at St. Rita School in Solon, Following are descriptions of some of the

PHOTO S COURTESY OF CLEVELAND CLINIC the entire school planned a two-week events that took place in 2017 and early 2018. fundraiser for VeloSano Kids, raising $13,000 to support pediatric cancer 2017 research. The two teachers raising the Liver Transplant Golf Outing most with their students squared off in Doug Cowan hosted the third annual liver a bike race around the school, with the transplant golf outing at Catawba Island teacher who lost serving lunch in the Club in Port Clinton, Ohio, raising over cafeteria the next school day. $75,000 for the Cowan Family Chair for To involve your children in events Living Donations in Liver Transplants at such as Trike & Bike beneﬁting Cleveland Clinic. VeloSano Kids, please visit giving.ccf.org/ (Continued on page 14) trikeandbike.

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Empower Little Heroes Coldwell Banker Schmidt Family of Companies hosted its fi fth annual event at Progressive Field, with Cleveland Lerner School Clinic Children’s patient Jack Sparent throwing out the fi rst pitch. Indians player Andrew Miller, who met Jack while he was at Children’s Center for Rehabilitation, Marks 10 Years of went onto the fi eld to wish him luck. The event raised $33,818 for the Child Life Program at Children’s. Life-Changing Education Mary Pickett Memorial Golf Outing Mike Pickett hosted the Third Annual Mary Pickett Memorial Golf Outing in memory of his mother. Owen, 4, recently graduated from Nearly $26,000 was raised in support of polycys- the Lerner School in Cleveland Clinic’s tic kidney disease research at Cleveland Clinic’s Center for Autism. When he started, Glickman Urological & Kidney Institute. he could use only a few words and was unable to take part in many activities Gathering for Good that his peers could. Now, he converses Kim Crane, Meg Nowlin, Natalie Rini and Charity with his friends and loves running, D’Amato hosted the fi rst Gathering for Good event in climbing, jumping and playing. He Rocky River, Ohio, featuring a steel drum band, vin- transitioned out of the Lerner School on tage furnishings and a silent auction. Over $40,000 Feb. 15. Today, he is a full-time student was raised for Children’s pediatric cancer research. in his school district and is a peer model Evening for an Angel for other students. Carla Capuzzo and her family hosted An Evening for ---- an Angel Clambake in memory of her son, Joey. The Tanya, 13, is in the Lerner School’s intermediate 1 classroom. sold-out event raised $23,500 for Children’s pediatric Since starting at the school in 2016, she has learned to use an iPad hematology research. to communicate. She surprised her parents this past Christmas by adding pictures to it by herself to show them which toys she wanted. Crosse Out Cancer She also participates in community outings with her class, and, last Burning River Lacrosse hosted the 2017 Crosse Out summer, took her first overnight trip with her parents to attend her Cancer event at the Pro Football Hall of Fame. More brother’s sporting event. than 1,970 fans, coaches and offi cials attended, and 23 teams competed in the tournament. The event raised over $24,500 for Cleveland Clinic’s PHOTOS COURTESY OF CLEVELAND CLINIC CLEVELAND OF COURTESY PHOTOS Owen and Tanya are among intervention needs. Currently, Comprehensive Breast Cancer Program. 320 students from 31 school 104 students are enrolled at the Union Local Elementary School districts who have attended school—64 school-age and 40 — We Can “Change” Epilepsy the Lerner School in Cleveland preschool students. Fundraiser Clinic’s Center for Autism since Nine students who are 6 years Union Local Elementary School it opened 10 years ago. old or older and 74 preschool rallied around a classmate with The chartered, private day students, including Owen, its weeklong “We Can Change” school, launched by gifts from have transitioned to other fundraiser supporting Cleveland Norma Lerner and Mort and educational environments, Clinic Children’s Pediatric Iris November, is certifi ed by typically in public schools. Epilepsy Center. The event allowed students to learn the state of Ohio and serves The school’s educational about pediatric epilepsy and how they can make students from diagnosis to program emphasizes research- a difference. Over $3,500 was raised through coin age 22. Before the school based autism intervention drives, fundraising nights at local restaurants and opened, students were taught stemming from the philosophy sales of student-crafted blankets. in a small classroom within and interventional techniques Cleveland Clinic’s Hospital for of applied behavior analysis 2018 Rehabilitation. In 2008, with a (ABA). It is a full-day, year-round Corpus Christi Academy growing student population, the program, with strong parental The fourth- and fi fth-grade program was moved into a new involvement, low student-to- girls’ basketball team at Corpus addition adjacent to that site staff ratio, highly individualized Christi Academy rallied around and named the Lerner School programs and tiered levels of a friend through “Hoops to Help” for Autism. Classes are held in instruction. for Pediatric Cancer Research at the Debra Ann November Wing. For students approaching Cleveland Clinic Children’s. For In 2015, another preschool graduation, the Lerner School every free-throw, friends and fam- classroom was added to focuses on adult transition and ily contributed to the cause. In 2017, accommodate growing early partners with 10 job sites. the team raised over $1,400. In 2018, they doubled that amount by adding a Dress-down Day at school and hosting a raffle, raising over $3,000. 14 CATALYST | SUMMER 2018 | POWEROFEVERYONE.ORG

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RESEARCH Stem Cells May Be Key to Safer Opioids INVESTIGATION OFFERS HOPE FOR MORE EFFECTIVE PAIN MANAGEMENT

Opioid addiction and “We already knew that that they remain important overdoses have led to a national mesenchymal stem cells had therapeutically. health crisis. A contributing factor powerful anti-inflammatory “For some types of pain and in is opioid tolerance (OT), in which effects,” he says. “And we knew situations where other treatments increasingly stronger doses are inflammation played a role in don’t help—including cancer needed to achieve the same chronic pain, nerve pain and pain, sickle cell crisis and back level of pain relief. Paradoxically, in opioid tolerance. In future pain, despite repeat surgeries— the continued use of opioids research, we want to understand opioids are the most effective to manage pain often leads to the molecular and cellular option,” he says. “But taking opioid-induced hyperalgesia mechanisms better.” higher and higher doses leads (OIH), in which the drugs actually Results from his studies to sedation and raises the risk intensify pain sensitivity. garnered attention among of fatal respiratory problems. If Recent laboratory studies led pain researchers in 2016 when our research elicits the same by Jianguo Cheng, MD, PhD, of published in the journal Scientific effects in people that we’ve Cleveland Clinic’s Department of Reports, and again in 2017 in the found in the lab, it could lead to Pain Management and Director journal Clinical Pharmacology & an add-on therapy that would of the Multidisciplinary Pain Therapeutics. Pending funding prevent the need for increasing Medicine Fellowship Program, and FDA approval, Dr. Cheng doses. Opioids would be safer. suggest that a promising solution hopes to begin a clinical trial This could have a big impact to these problems may lie in within a year. on clinical practice for pain stem cell therapy. Despite the widely publicized management and critical care.” Dr. Cheng and his research dangers of opioids, he notes SARI HARRAR team have found that transplanting mesenchymal stem cells can prevent and reverse opioid tolerance and opioid-induced hyperalgesia. The teams worked with mesenchymal stem cells—a type of adult stem cell— because they “have a track record of safety in human research and currently are used in hundreds of human studies,” Dr. Cheng says. Stem cells seem to help combat OT and OIH by tamping

MAN_AT_MOUSE/GETTY IMAGES down inflammation in the brain, says Dr. Cheng, who also is President of the American Academy of Pain Medicine.

JIANGUO CHENG, MD, PHD, AND HIS RESEARCH TEAM HAVE FOUND THAT TRANSPLANTING CERTAIN STEM CELLS CAN PREVENT AND, IN SOME CASES, REVERSE OPIOID TOLERANCE THAT OFTEN LEADS TO ADDICTION.

THE POWER OF EVERY DISCOVERY POWEROFEVERYONE.ORG | SUMMER 2018 | CATALYST 15

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The Pursuit of New Treatments for Deadly Brain Cancer RESEARCH TARGETS THE ROLE OF BLOOD VESSEL FORMATION

By Candece Gladson, MD

Glioblastoma is the most work investigating some common type of cancer key differences between that starts in the brain, and it blood vessel cells that also is the most aggressive. are isolated from brain Usually, it is seen in people tumors as compared with around age 54 to 64, more those that are isolated often in men than in women. from the normal brain. This Currently, there is no way to study has identifi ed new prevent it, and typically, the targets that could lead to R1, known as a “death collaborations with other cancer recurs after treatment. the development of new receptor,” is abundant in researchers at Cleveland The average length of therapies for treating the cells that make up Clinic and outside survival is 12 to 15 months, but brain tumors. tumor blood vessels and institutions and has wider without treatment, survival is • Pro-cancer effect of that this receptor also implications than brain around three months. anti-cancer drug: We can be separated from tumors. We are moving To beat this disease, we learned that a drug called the blood vessel cell’s toward better strategies must fi nd new treatments, bevacizumab (beevah- surface. Separation allows in overcoming a variety of and those begin with sis-amab), used routinely it to circulate in the blood. cancers that rely on new understanding—which in treating patients with Higher levels of this death blood vessel formation for comes through research. recurrent glioblastoma, receptor in the blood their survival. With the help My team at Cleveland has a downside. It is used correlate with a worse of philanthropy, we hope Clinic’s Lerner Research because of its ability to prognosis for patients with to change and improve Institute recently made slow tumor growth by recurrent brain tumors. our approach to cancer some exciting fi ndings that inhibiting formation of Our team’s work is treatment, saving and help us better understand blood vessels. However, strengthened by our extending thousands of lives. angiogenesis, the process we found that it also can of new blood vessel stimulate the survival of formation. This process aggressive cancer stem contributes to the growth cells, preventing a tumor Candece Gladson, MD, is a member and spread of tumors, such from responding to the of the Lerner Research Institute’s as glioblastoma. very drug that is being Department of Cancer Biology and We have made progress used to treat it. also the Rose Ella Burkhardt Brain in several respects: • Death receptors: Tumor and Neuro-Oncology Center • Blood vessel cells: We have shown that We have completed a protein called TNF-

WITH THE HELP OF PHILANTHROPY, WE HOPE TO CHANGE AND IMPROVE OUR APPROACH TO CANCER

TREATMENT, SAVING AND EXTENDING THOUSANDS OF LIVES. IMAGES REINE/GETTY GUNITA

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Muscle Power for Pedaling

More than 280,000 people in the stand, transfer between seats These advances helped ﬁ ve U.S. with spinal cord injuries and step short distances. Dr. individuals independently bike face declining health because of Marasco works with local research outside, and, with training, limited ability to exercise. They teams who have pioneered the compete in the 2016 Cybathlon, are restricted to specialized gyms, use of these systems to improve an FES bike race in Zurich, upper-body workouts and manual quality of life for those with spinal Switzerland—where Team wheelchair use, says Paul Marasco, cord injury. Cleveland won gold. PHOTO BY DON GERDA, CLEVELAND CLINIC PHOTOGRAPHY PhD, of the Biomedical Engineering In 2016, Dr. Marasco and the With philanthropic funding, Dr. Department at Cleveland Clinic’s team applied the FES implants Marasco says, the research team Lerner Research Institute. to cycling. The nerve stimulation could reﬁ ne their design and offer In recent years, special neural technology was adapted to read more people with spinal cord injuries implants (functional electrical the position of a bike’s cranks to increased mobility, better health stimulation, or FES) have made it rhythmically stimulate muscles for and the freedom to bike in the great possible for these individuals to pedaling power. outdoors under their own power.

visit powerofeveryone.org to learn more THE POWER OF EVERY DISCOVERY

Catalyst_SU18_C3_Innovation.indd 3 5/17/18 10:57 AM The Cleveland Clinic Foundation The Philanthropy Institute/DV3 3050 Science Park Drive, AC/322, Beachwood OH 44122 powerofeveryone.org

The 2017 Pre-K graduating class at the Lerner School for Autism. The school marks 10 years of life-changing education.

Cleveland Clinic Catalyst is published by the Philanthropy Institute for friends and benefactors of Cleveland Clinic.

Cleveland Clinic, founded in 1921, integrates clinical and hospital care with research and education in a private, nonproﬁt group practice. Cleveland Clinic depends on the generosity of individuals, families, Volume 16 | Issue 1 Summer 2018 corporations and foundations to ensure its continued excellence Kathryn DeLong, Director, Development Communications in patient care, medical research and education. Elaine DeRosa Lea, Communications Manager Cleveland Clinic realizes that individuals would like to learn more about Editorial, Design and Project Management by its particular programs, services or developments. At the same time, we fully respect the privacy of our patients. If you do not wish to receive any materials containing this information, please call us at 855.714.3898, fax us at 216.448.0678 or write to us at: The Philanthropy Institute, Cleveland Clinic, 3050 Science Park Drive, AC/322, Beachwood OH 44122.

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FPO PHOTOGRAPHY CLINIC CLEVELAND GERDA, DON BY PHOTO

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