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Ulceroglandular Tularemia: a Typical Case of Relapse

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Ulceroglandular Tularemia: a Typical Case of Relapse Henry Ford Hospital Medical Journal Volume 37 Number 2 Article 6 6-1989 Ulceroglandular Tularemia: A Typical Case of Relapse Stanley D. Miller Michael B. Snyder Michael Kleerekoper Colby H. Grossman Follow this and additional works at: https://scholarlycommons.henryford.com/hfhmedjournal Part of the Life Sciences Commons, Medical Specialties Commons, and the Public Health Commons Recommended Citation Miller, Stanley D.; Snyder, Michael B.; Kleerekoper, Michael; and Grossman, Colby H. (1989) "Ulceroglandular Tularemia: A Typical Case of Relapse," Henry Ford Hospital Medical Journal : Vol. 37 : No. 2 , 73-75. Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol37/iss2/6 This Article is brought to you for free and open access by Henry Ford Health System Scholarly Commons. It has been accepted for inclusion in Henry Ford Hospital Medical Journal by an authorized editor of Henry Ford Health System Scholarly Commons. Ulceroglandular Tularemia: A Typical Case of Relapse Stanley D. Miller, MD,* Michael B. Snyder, MD,^ Michael Kleerekoper, MD,* and Colby H. Grossman, MD§ Tularemia is an infectious disease that continues to occur sporadically and in epidemics in the United States. It is characterized as an acute febrile illness with constitutional symptoms associated with skin, glandular, respiratory, or gastrointestinal involvement. Tularemia usually can be treated effectively with .streptomycin. Relapse most often occurs when patients are treated with bacteriostatic agents such as chloramphenicol or tetracycline. We present a case of ulceroglandular tularemia distinguished by its relapse after initial streptomycini doxy cy cline therapy and subsequent slow response to additional streptomycin. (Henry Ford Hosp Med J 1989:37:73-5) ularemia has been recognized since the early 1900s as an sented to the local emergency room and was admitted for intravenous Tinfectious disease with diverse manifestations (1). The antibiotic therapy. Treatment consisted of imipenem, 500 mg intra­ etiologic agent, Francisella tularensis, is a gram-negative coc- venous piggypack every six hours for days 1 through 8, followed by cobacillus that after transmission through dck bite, ingestion, or streptomycin, 500 mg intramuscularly every 12 hours, cefazolin, 2 g by aerosol or direct contact with infected animals causes an intravenous piggypack every eight hours, and doxycycline, 100 mg or­ acute febrile illness associated with skin, glandular, respiratory, ally twice daily, for days 9 through 13. His hospital course was compli­ cated by painful adenopathy, especially in the left epitrochlear and ax­ or gastrointestinal findings. Rabbits, hares, and ticks are the illary areas. Aspiration of the epitrochlear node revealed frank pus most common carriers. Tick-borne cases predominate in spring which on Gram's stain showed no organisms. Cultures were negative and summer whereas rabbit-associated cases are prevalent in the for aerobic, anaerobic, and mycobacterial pathogens. winter (2). Patients develop one of the following syndromes: ul­ Serology for tularemia, brucellosis, and toxoplasmosis was also ceroglandular (75% to 85% of cases), glandular (5% to 10%), negative at the time of his discharge. Only slight left arm tenderness and typhoidal (5% to 15%), or oculoglandular (1% to 2%). swelling remained. Discharge medications included 500 mg of oral Pleuropulmonary complications can occur and may mimic cephalexin every eight hours and 100 mg of doxycycline twice daily un­ atypical pneumonia similar to that seen with mycoplasma or til completion of ten days of therapy for suspected tularemia. He re­ Legionella infections (3). The population at risk includes farm­ turned to the Detroit area. Nine days after discharge he experienced a ers, sheep shearers, and laboratory workers. There is no known recurrence of symptoms while still on antibiotic therapy. Symptoms in­ human-to-human transmission. Effective therapy consists of in­ cluded increased left arm swelling and tenderness, headache, nausea, tramuscular streptomycin (4). and fever He did not have any symptoms of cough, diarrhea, and ab­ dominal or chest pain. He presented to the Henry Ford Hospital emer­ We describe a padent with a complicated course of tularemia gency room four days later with a temperature of 38.9°C (I02°F), pulse because of his initial relapse after effective antibiotics and sub­ of 80 beats/min, blood pressure of 122/78 mm Hg, and respiration of 16 sequent slow response to repeat therapy. The clinical course breaths/min. The patient was alert and oriented but appeared in moder­ prompted consideration for surgical intervention. ate distress, splinting his left arm to his abdomen. A 2 x 4 cm area of cellulitis and swelling was noted over the left epitrochlear area (Fig 1). Case Report There was also a 4 x 5 cm area of induration and erythema in the left axilla that was exquisitely tender to touch (Fig 2). Fluctuance, ulcera­ A previously healthy 43-year-old man was admitted to Henry Ford tion, lymphadenitis, and drainage were not noted. A Vi cm healed lac- Hospital in December 1988 complaining of a five-week history of fever, chills, sweats, arthralgias, headaches, and swelling of the left arm. He had spent Thanksgiving in rural South Carolina where he suffered a lac­ eration to his left second finger while cutting raccoon meat one day prior to serving it for the holiday dinner Three days later, he awoke complaining of generalized arthralgias and developed a severe, per­ Submitted for publication: July 6. 1989. Accepled tor publication; August 1. 1989. sistent occipital headache. About 72 hours later, he noted increased *Formerly Division of Infectious Diseases and Hospital Epidemiology. Henry Ford Hos­ swelling ofthe medial left arm with tenderness over the epitrochlear and pital. Currently Departmenl of Infection Control, Oakwood Hospilal, Detroit. axillary areas. No other family members became ill. Gradually a pur­ tFormerly Division of Infectious Diseases and Hospilal Epidemiology. Henry Ford Hos­ pital. Currently Department of Ambulatory Health Services. Mount Sinai Hospital. ulent drainage developed at the laceration site, and he was seen by a Detroit. local physician who incised and drained the finger and prescribed oral JBone and Mineral Division. Henry Ford Hospilal. erythromycin. The arthralgias subsided but the cellulitis and constitu­ §Tridcnt Regional Hospital. Charleston. SC. Address correspondence lo Dr Miller. Department of Infection Control. Oakwood Hos­ tional symptoms persisted. Fourteen days after the laceration, he pre­ pital. 18101 Oakvv'ood Blvd. Dearborn. MI 48124. Henry Ford Hosp Med J—Vol 37, No 2, 1989 Ulceroglandular Tularemia—Miller et al 73 Fig 1—Ulceroglandular tularemia with epitrochlear and axil­ Fig 2—View ofthe axillary swelling and cellulitis. lary adenitis. eration was present at the distal medial second finger with surrounding were classic presentadons (5). Skin exposure, rather than inges­ purple discoloration. The rest of the physical examination was tion, was the probable mode of transmission since none of unremarkable. the family members became ill and gastrointesdnal symptoms WBC count was 19.2 lO'VL ( 19,200/|JLL) with 0.48 (48%) neu­ were absent. trophils, 0.06 (6%) bands, 0.34 (34%) lymphocytes, and 0.07 (7%) Our patient fulfilled the criteria for the ulcer-node syndrome. monocytes. His hemoglobin was 123 g/L (12.3 g/dL), creatinine 106 The differential diagnosis includes rat-bite fever (6), Pasteurella (t,mol/L (1.2 mg/dL), and ESR 79 mm/h. Monospot and hepatitis B sur­ (7), cat-scratch disease (8), Mycobacterium marinum (9), no­ face antigen tests were negative. Liver function test results were mildly elevated with an aspartate aminotransfera.se of 1.15 |xkat/L (69 U/L), cardiosis (10), sporotrichosis (11), cutaneous anthrax (12), alanine aminotransferase of 1.53 ixkat/L (92 U/L), alkaline phosphatase Erysipelothrix (13), tularemia (5), staphylococcal or streptococ­ of 2.1 (jikat/L (126 U/L), and gamma-glutamyltransferase of 1.72 jjikat/ cal lymphangitis (14), brucellosis (15), Listeria (\6), syphilis L (103 U/L). Chest roentgenogram was negative. A needle aspirate of (17), lymphogranuloma venereum (18), scrub typhus (19), or the left epitrochlear area revealed on Gram's stain numerous "question­ plague (20). He denied any history of animal bite or scratch, able" gram-negative bacilli. contaminated percutaneous inoculation, sexually transmitted After routine cultures of sputum, blood, and urine were obtained, he diseases, tick bites, or exposure to sick animals or their hides, was started on cefazolin, 1 g intravenous piggypack every eight hours, gardening, or fish tanks. The history of cutaneous exposure and streptomycin, 500 mg intramuscularly every 12 hours. The nodal while cleaning raccoon meat with subsequent ulcer formadon aspirate was sent for aerobic, anaerobic, fungal, and mycobacterial and lymphadenitis strongly suggested the diagnosis of cultures. An ultrasound of the left axilla was negative for abscess. tularemia. Within 24 hours, his left arm pain subsided. The fever, headache, and arthralgias decreased over the next three days. Swelling and cellulitis The diagnosis of tularemia is usually confirmed by serologic improved slowly over the following week. Due to the sluggish re­ testing. It is not surprising that bacterial agglutinins were ini­ sponse, lymph node excision was discussed but abandoned. Strep­ tially absent in our patient. In a study of 65 patients, Evans et al tomycin therapy was continued for 14 days
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