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Nº: 5PSQ-069 ATC code: M05 Roura J1, Rovira M1,2, Socoro N1, Ruiz S1, Sotoca JM1,2 1 Pharmacy Service, Division of Medicines, Hospital Clínic Barcelona, Barelona, Spain 2 Consorci d’Atenció Primària de Salut de Barcelona Esquerra, Barcelona, Spain [email protected] BACKGROUND AND IMPORTANCE • Falls among the older population are associated with a high morbidity and mortality. • The etiology of falls is usually multifactorial and the use of several types of drugs has been associated with an increased fall risk. • Since drugs are a modifiable risk factor, periodic drug review and eventual withdrawal of drug-related falls could be a possible strategy to prevent falls in this population. AIM AND OBJECTIVES The aim was to analyze the proportion of patients who were treated for osteoporosis and were taking, concomitantly, any drug that increase fall risk. MATERIAL AND METHODS q Observational, retrospective study in three primary care centres covering a population of 97,722 people. q Study population: patients with a prescription of any drug for osteoporosis. q Data collected were: age, gender, drugs for osteoporosis treatment and drugs that have a medium or high fall risk. RESULTS q 1,594 patients were treated with drugs for q Patients according to the number of drugs with osteoporosis falling risk concomitantly prescribed: 38.5% had Demographic data (n=1,594) one; 30.5% two; 17.9% three; 8.7% four and 4.4% five or more. Age – years* 72.4 ± 10.6 q Drugs for osteoporosis treatment are represented Female sex – n (%) 1,457 (91.5) in Figure 1. Patients with an active prescription of a 1,102 (69.1) q drug that increase fall risk – n (%) The most prescribed drug-related falls were *mean ± standard deviation (SD) anxiolytics and antidepressants. Drugs for osteoporosis Drug-related falls Anxiolytics - N05B 1% 0.1% 2% Alendronate Antidepressants - N06A 3% 3% 7% 4% Denosumab Beta-blockers - C07A 21% 6% Alendronic acid + colecalciferol 5% Angiotensin-convertor enzyme inhibitor - C09A 6% Opioid analgesic - N02A 6% Risedronate Calcium antagonists - C08C Ibandronate 4% Antiepileptics - N03A Raloxifene 8% 15% Angiotensin II receptor antagonists 20% 63% Teriparatide - C09C Hyptnotics and sedatives - N05C 8% Bazedoxifene Antihypertensives + diuretics - C09D+C09B Etidronate 9% 9% Neuroleptics and antipsycotics - N05A Figure 1. Drugs for osteoporosis treatment prescribed, expressed in %. Figure 2. Prescription of drugs that increase fall risk, expressed in %. CONCLUSION AND RELEVANCE Concomitant prescription of drugs for osteoporosis and drugs that increase fall risk is common. Periodic drug review is required to reassess the necessity of continuing drugs that contribute to fall risk in patients treated for osteoporosis. Authors declare no conflict of interest.

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