SupplementaryTable 3

A. p-value or Pathway or Network ID Function score # Genes Inflammatory Response 6.83E-23 – 64 1.83E-02 immune response 6.83E-23 45 activation of leukocytes 7.2E-12 20 activation of mononuclear leukocytes 5.93E-11 16 activation of lymphocytes 1.02E-10 15 activation of T lymphocytes 2.84E-10 13 inflammatory response 1.21E-05 17 chemotaxis of leukocytes 1.52E-05 13 chemotaxis of granulocytes 1.79E-05 9 chemotaxis of 3.12E-05 5 binding of phagocytes 0.000113 5 chemotaxis of T lymphocytes 0.000137 6 response 0.000162 5

Inflammatory Disease 2.01E-05- 85 1.76E-03 inflammatory disorder 2.01E-05 85 rheumatic disease 1.34E-05 60 arthritis 2.61E-05 58 rheumatoid arthritis 4.72E-05 53 multiple sclerosis 4.82E-04 12 dermatitis 1.31E-05 11 asthma 4.79E-05 11 systemic erythematosus 1.84E-06 10 atopic dermatitis 6.64E-06 10 juvenile rheumatoid arthritis 1.17E-05 10

Immunological Disease 1.26E-09 – 90 1.83E-02 immunological disorder 1.26E-09 90 systemic lupus erythematosus 1.84E-06 10 hypersensitive reaction 2.98E-06 12 atopic dermatitis 6.64E-06 10 Sjogren's syndrome 9.59E-06 8 juvenile rheumatoid arthritis 1.17E-05 10 rheumatoid arthritis 4.72E-05 53 autoimmune disease 4.92E-05 68 B. UGRepAcc Symbol Name NM_000022 ADA adenosine deaminase NM_004833 AIM2 absent in melanoma 2 NM_000041 APOE apolipoprotein E NM_032415 CARD11 caspase recruitment domain family, member 11 NM_006072 CCL26 (C-C motif) ligand 26 NM_002985 CCL5 chemokine (C-C motif) ligand 5 NM_004244 CD163 CD163 molecule NM_001767 CD2 CD2 molecule NM_000616 CD4 CD4 molecule NM_001256030 CD48 CD48 molecule NM_001040280 CD83 CD83 molecule NM_001184879 CD84 CD84 molecule NM_001206924 CD86 CD86 molecule NM_000246 CIITA class II, major histocompatibility complex, transactivator NM_003650 CST7 cystatin F (leukocystatin) NM_001037631 CTLA4 cytotoxic T-lymphocyte-associated 4 NM_001114173 CTSC cathepsin C NM_001199739 CTSS cathepsin S NM_000397 CYBB cytochrome b-245, beta polypeptide NM_000639 FASLG (TNF superfamily, member 6) NM_004106 FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide NM_001002273 FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) NM_001243093 FYB FYN binding protein granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine NM_006144 GZMA esterase 3) HLA- NM_019111 DRA major histocompatibility complex, class II, DR alpha NM_012092 ICOS inducible T-cell co-stimulator NM_005849 IGSF6 immunoglobulin superfamily, member 6 inhibitor of kappa polypeptide gene enhancer in B-cells, kinase NM_001099856 IKBKG gamma NM_000417 IL2RA 2 receptor, alpha NM_001012631 IL32 NM_000418 IL4R receptor NM_002163 IRF8 regulatory factor 8 NM_000632 ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) NM_000211 ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) NM_001014987 LAT linker for activation of T cells lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte NM_005565 LCP2 protein of 76kDa) leukocyte immunoglobulin-like receptor, subfamily A (without TM NM_001172654 LILRA3 domain), member 3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and NM_001081637 LILRB1 ITIM domains), member 1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and NM_001081450 LILRB3 ITIM domains), member 3 NM_002341 LTB beta (TNF superfamily, member 3) NM_000433 NCF2 neutrophil cytosolic factor 2 NM_001039508 SIRPG signal-regulatory protein gamma NM_000594 TNF TNFSF13 NM_001145645 B tumor necrosis factor (ligand) superfamily, member 13b NM_001173514 TYROBP TYRO protein tyrosine kinase binding protein