Understanding Brachytherapy
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Internal Radiation Therapy, Places Radioactive Material Directly Inside Or Next to the Tumor
Brachytherapy Brachytherapy is a type of radiation therapy used to treat cancer. It places radioactive sources inside the patient to kill cancer cells and shrink tumors. This allows your doctor to use a higher total dose of radiation to treat a smaller area in less time. Your doctor will tell you how to prepare and whether you will need medical imaging. Your doctor may use a computer program to plan your therapy. What is brachytherapy and how is it used? External beam radiation therapy (EBRT) directs high-energy x-ray beams at a tumor from outside the body. Brachytherapy, also called internal radiation therapy, places radioactive material directly inside or next to the tumor. It uses a higher total dose of radiation to treat a smaller area in less time than EBRT. Brachytherapy treats cancers throughout the body, including the: prostate - see the Prostate Cancer Treatment (https://www.radiologyinfo.org/en/info/pros_cancer) page cervix - see the Cervical Cancer Treatment (https://www.radiologyinfo.org/en/info/cervical-cancer-therapy) page head and neck - see the Head and Neck Cancer Treatment (https://www.radiologyinfo.org/en/info/hdneck) page skin breast - see the Breast Cancer Treatment (https://www.radiologyinfo.org/en/info/breast-cancer-therapy) page gallbladder uterus vagina lung - see the Lung Cancer Treatment (https://www.radiologyinfo.org/en/info/lung-cancer-therapy) page rectum eye Brachytherapy is seldom used in children. However, brachytherapy has the advantage of using a highly localized dose of radiation. This means that less radiation is delivered to surrounding tissue. This significantly decreases the risk of radiation-induced second malignancies, a serious concern in children. -
NUREG-1350, Vol. 31, Information
NRC Figure 31. Moisture Density Guage Bioshield Gauge Surface Detectors Depth Radiation Source GLOSSARY 159 GLOSSARY Glossary (Abbreviations, Definitions, and Illustrations) Advanced reactors Reactors that differ from today’s reactors primarily by their use of inert gases, molten salt mixtures, or liquid metals to cool the reactor core. Advanced reactors can also consider fuel materials and designs that differ radically from today’s enriched-uranium dioxide pellets within zirconium cladding. Agreement State A U.S. State that has signed an agreement with the U.S. Nuclear Regulatory Commission (NRC) authorizing the State to regulate certain uses of radioactive materials within the State. Atomic energy The energy that is released through a nuclear reaction or radioactive decay process. One kind of nuclear reaction is fission, which occurs in a nuclear reactor and releases energy, usually in the form of heat and radiation. In a nuclear power plant, this heat is used to boil water to produce steam that can be used to drive large turbines. The turbines drive generators to produce electrical power. NUCLEUS FRAGMENT Nuclear Reaction NUCLEUS NEW NEUTRON NEUTRON Background radiation The natural radiation that is always present in the environment. It includes cosmic radiation that comes from the sun and stars, terrestrial radiation that comes from the Earth, and internal radiation that exists in all living things and enters organisms by ingestion or inhalation. The typical average individual exposure in the United States from natural background sources is about 310 millirem (3.1 millisievert) per year. 160 8 GLOSSARY 8 Boiling-water reactor (BWR) A nuclear reactor in which water is boiled using heat released from fission. -
Standards for Radiation Oncology
Standards for Radiation Oncology Radiation Oncology is the independent field of medicine which deals with the therapeutic applications of radiant energy and its modifiers as well as the study and management of cancer and other diseases. The American College of Radiation Oncology (ACRO) is a nonprofit professional organization whose primary purposes are to advance the science of radiation oncology, improve service to patients, study the socioeconomic aspects of the practice of radiation oncology, and provide information to and encourage continuing education for radiation oncologists, medical physicists, and persons practicing in allied professional fields. As part of its mission, the American College of Radiation Oncology has developed a Practice Accreditation Program, consisting of standards for Radiation Oncology and standards for Physics/External Beam Therapy. Accreditation is a voluntary process in which professional peers identify standards indicative of a high quality practice in a given field, and which recognizes entities that meet these high professional standards. Each standard in ACRO’s Practice Accreditation Program requires extensive peer review and the approval of the ACRO Standards Committee as well as the ACRO Board of Chancellors. The standards recognize that the safe and effective use of ionizing radiation requires specific training, skills and techniques as described in this document. The ACRO will periodically define new standards for radiation oncology practice to help advance the science of radiation oncology and to improve the quality of service to patients throughout the United States. Existing standards will be reviewed for revision or renewal as appropriate on their third anniversary or sooner, if indicated. The ACRO standards are not rules, but rather attempts to define principles of practice that are indicative of high quality care in radiation oncology. -
Review of Outpatient Brachytherapy Medicare Payments to Carolinas Medical Center
DEPARTMENT OF HEALTH & HUMAN SERVICES OFFICE OF INSPECTOR GENERAL Office of Audit Services, Region IV 61 Forsyth Street, SW, Suite 3T41 Atlanta, GA 30303 February 6, 2012 Report Number: A-04-11-06135 Ms. Suzanne Freeman Divisional President Carolinas Medical Center P.O. Box 32861 Charlotte, NC 28232-2861 Dear Ms. Freeman: Enclosed is the U.S. Department of Health and Human Services (HHS), Office of Inspector General (OIG), final report entitled Review of Outpatient Brachytherapy Medicare Payments to Carolinas Medical Center. We will forward a copy of this report to the HHS action official noted on the following page for review and any action deemed necessary. The HHS action official will make final determination as to actions taken on all matters reported. We request that you respond to this official within 30 days from the date of this letter. Your response should present any comments or additional information that you believe may have a bearing on the final determination. Section 8L of the Inspector General Act, 5 U.S.C. App., requires that OIG post its publicly available reports on the OIG Web site. Accordingly, this report will be posted at http://oig.hhs.gov. If you have any questions or comments about this report, please do not hesitate to call me, or contact Andrew Funtal, Audit Manager, at (404) 562-7762 or through email at [email protected]. Please refer to report number A-04-11-06135 in all correspondence. Sincerely, /Lori S. Pilcher/ Regional Inspector General for Audit Services Enclosure Page 2 – Ms. Suzanne Freeman Direct Reply to HHS Action Official: Nanette Foster Reilly Consortium Administrator Consortium for Financial Management & Fee for Service Operations Centers for Medicare & Medicaid Services 601 East 12th Street, Room 235 Kansas City, Missouri 64106 Department of Health and Human Services OFFICE OF INSPECTOR GENERAL REVIEW OF OUTPATIENT BRACHYTHERAPY MEDICARE PAYMENTS TO CAROLINAS MEDICAL CENTER Daniel R. -
Radiation Quick Reference Guide Recommend Contacting Your State Fusion Center
Domestic Nuclear Detection Office If you encounter something suspicious follow your specific local protocols. Radiation Quick Reference Guide Recommend contacting your state fusion center. DNDO is available 24/7 to assist at 1-877-DNDO-JAC / 1-877-363-6522 JAC Information Line 202-254-7179 Email: [email protected] Nuclear Concerns/ Threats 1. Nuclear Weapon - a device that releases nuclear energy in an ex- Isotopes of Concern for use in RDDs - with common uses plosive manner. Uses Highly Enriched Uranium (HEU) and/or 1. Cobalt-60 – cancer treatment, level/ Plutonium. density gauge, teletherapy, radiography, 2. Improvised Nuclear Device (IND) - a nuclear weapon fabricated food sterilization/irradiation, by a terrorist organization or rogue nation. brachytherapy 2. Iridium-192 – Radiography/non- destructive testing, flaw detection, brachy- therapy “cancer seed”, skin cancer Cobalt 60 sources Uranium “superficial” brachytherapy Plutonium 3. Uranium a. Uranium exists naturally in the earth’s crust. Of the different “isotopes” of uranium, U-235 is the one required to produce a Iridium sentinel and nuclear weapon. gamma camera b. Natural uranium contains a small amount of U-235 (<1%) which Cesium Seeds must be separated in complex extraction processes to create HEU. The predominant uranium isotope is U-238. 3. Cesium-137 - Gauge/level gauge, industrial radiography, brachyther- c. Highly Enriched Uranium (HEU) refers to uranium usable in weap- apy/teletherapy, well logging/density gauges ons due to its enrichment in U-235. 4. Strontium-90 – Radioisotope thermoelectric generator (RTG), fis- d. Approximately 25 kg of HEU is required for a nuclear weapon. sion product, industrial gauges, medical treatment e. -
The Impact of County-Level Radiation Oncologist Density on Prostate Cancer Mortality in the United States
Prostate Cancer and Prostatic Diseases (2012) 15, 391 -- 396 & 2012 Macmillan Publishers Limited All rights reserved 1365-7852/12 www.nature.com/pcan ORIGINAL ARTICLE The impact of county-level radiation oncologist density on prostate cancer mortality in the United States S Aneja1 and JB Yu1,2,3 BACKGROUND: The distribution of radiation oncologists across the United States varies significantly among geographic regions. Accompanying these variations exist geographic variations in prostate cancer mortality. Prostate cancer outcomes have been linked to variations in urologist density, however, the impact of geographic variation in the radiation oncologist workforce and prostate cancer mortality has yet to be investigated. The goal of this study was to determine the effect of increasing radiation oncologist density on regional prostate cancer mortality. METHODS: Using county-level prostate cancer mortality data from the National Cancer Institute and Centers for Disease Control as well as physician workforce and health system data from the Area Resource File a regression model was built for prostate cancer mortality controlling for categorized radiation oncologist density, urologist density, county socioeconomic factors and pre-existing health system infrastructure. RESULTS: There was statistically significant reduction in prostate cancer mortality (3.91--5.45% reduction in mortality) in counties with at least 1 radiation oncologist compared with counties lacking radiation oncologists. However, increasing the density of radiation oncologists beyond 1 per 100 000 residents did not yield statistically significant incremental reductions in prostate cancer mortality. CONCLUSIONS: The presence of at least one radiation oncologist is associated with significant reductions in prostate cancer mortality within that county. However, the incremental benefit of increasing radiation oncologist density exhibits a plateau effect providing marginal benefit. -
Brachytherapy with Miniature Electronic X-Ray Sources
Brachytherapy with Miniature Electronic X-ray Sources Mark J. Rivard, Larry A. DeWerd, and Heather D. Zinkin Tufts-New England Medical Center, Boston, MA University of Wisconsin, Madison, WI DISCLOSURE Dr. Rivard serves as a consultant and Dr. DeWerd receives research support from Xoft, Inc. HISTORY Electronic brachytherapy (eBx) applies interstitial irradiation without radionuclides A miniature x-ray tube is commonly employed eBx conceived in the 1980s by Alan Sliski of PhotoElectron Corp. in collaboration with MIT Dosimetric properties and source characteristics first published in 1993 (Biggs et al., Gall et al., Smith et al.) in Medical Physics ~ 10 other companies pursued eBx since then RATIONALE Bx Source Advantages Disadvantages radionuclide Well established therapeutic use Fixed dosimetry properties Well established calibration procedures Radioactive waste concerns Fixed photon spectrum and half-life Regular source shipments due to decay High specific activity, small size electronic User-adjustable dose rate (on/off) Unproven clinical application User-adjustable dosimetric properties No NIST calibration protocol Lessened radiological exposure to staff Output variability amongst sources Typically larger in size No statements may be made at this time regarding cost differences or clinical results VENDOR SCOPE 1. Advanced X-ray Technologies Inc. Birmingham, MI 2. Carl Zeiss Ltd. Oberkochen, Germany 3. Xoft Inc. Fremont, CA Advanced X-ray Technologies Use of a primary and secondary targeting system with substantial polar and azimuthal -
Review White Paper (Pdf)
Brachytherapy: high precision, targeted radiotherapy Because life is for living Table of contents Executive summary 3 Introduction 4 Radiotherapy: present and future goals 5 Overview of brachytherapy 6 • Brachytherapy: high precision, targeted radiotherapy 6 Types of brachytherapy 7 Brachytherapy dosing 7 Brachytherapy efficacy and safety outcomes; patient benefits 8 • Brachytherapy in gynecological cancer 8 • Brachytherapy in prostate cancer 9 • Brachytherapy in breast cancer 12 • Brachytherapy in other cancers 14 • Brachytherapy in palliative care 15 Brachytherapy: setting benchmarks in radiation technology 15 • Advantages: technical and cost base 15 • Ongoing advances in brachytherapy result in improved outcomes and efficiency 16 Cost effectiveness: making efficient use of healthcare resources 17 Conclusions 19 Glossary 20 References 21 2 Brachytherapy: high precision, targeted radiotherapy Executive summary Radiotherapy is a key cornerstone of cancer care: this • The ability of brachytherapy to deliver high radiation White Paper reviews the role of brachytherapy – high doses over a short time period means patients can precision, targeted radiotherapy – in cancer treatment, complete treatment in days rather than the and discusses how it offers an effective, well tolerated weeks required for EBRT. For example, high dose rate radiation treatment option, tailored to the needs and (HDR) brachytherapy treatment for prostate cancer preferences of the individual patient. can be delivered in two treatment sessions, compared to several weeks with EBRT. This has important Brachytherapy combines two fundamental aims potential implications for patient compliance with of radiotherapy: an effective tumor dose with their radiotherapy treatment, as well as minimizing sparing of the surrounding tissue. Brachytherapy is impact on patients’ lives at the forefront of innovation in radiotherapy. -
Beta Irradiation: New Uses for an Old Treatment
Eye (2003) 17, 207–215 & 2003 Nature Publishing Group All rights reserved 0950-222X/03 $25.00 www.nature.com/eye 1 2;3 1;4 Beta irradiation: JF Kirwan , PH Constable , IE Murdoch and PT CLINICAL STUDY Khaw2;4 new uses for an old treatment: a review Abstract beta radiation in the prevention of restenosis following coronary balloon angioplasty or Beta radiation has a long history as a treatment stenting is highly topical. Placement of 32P wires modality in ophthalmology. It is a convenient markedly reduced subsequent restenosis rates and practical method of applying radiation in a recently reported randomised controlled and has the advantage of minimal tissue trial, and extensive investigation continues in penetration. There has been a recent this field.1,2 In ophthalmology, the role of both resurgence in the use of beta radiation in other external beam radiation and brachytherapy in areas in medicine, such as the prevention of the management of age-related macular restenosis after coronary artery stenting. Beta degeneration (ARMD) and the role of beta radiation has been shown in vitro and in vivo radiation in trabeculectomy are currently under to inhibit proliferation of human Tenon’s evaluation. It is therefore appropriate to revisit fibroblasts, which enter a period of growth the role of beta radiation in ophthalmology. arrest but do not die. Effects on the cell cycle controller p53 have been shown to be important in this process. In ophthalmology, beta radiation has been Beta radiation used widely for the treatment of pterygium Beta radiation is a particulate radiation and is under evaluation for treatment of age- consisting of high-speed electrons, which are 1Department of related macular degeneration and for rapidly attenuated by biological tissues (2 MeV Epidemiology and controlling wound healing after glaucoma beta particles have a range of only 1 cm in International Eye Health drainage surgery. -
Radiological Protection Issues in Endovascular Use of Radiation Sources
IAEA-TECDOC-1488 Radiological protection issues in endovascular use of radiation sources February 2006 IAEA SAFETY RELATED PUBLICATIONS IAEA SAFETY STANDARDS Under the terms of Article III of its Statute, the IAEA is authorized to establish or adopt standards of safety for protection of health and minimization of danger to life and property, and to provide for the application of these standards. The publications by means of which the IAEA establishes standards are issued in the IAEA Safety Standards Series. This series covers nuclear safety, radiation safety, transport safety and waste safety, and also general safety (i.e. all these areas of safety). The publication categories in the series are Safety Fundamentals, Safety Requirements and Safety Guides. Safety standards are coded according to their coverage: nuclear safety (NS), radiation safety (RS), transport safety (TS), waste safety (WS) and general safety (GS). Information on the IAEA’s safety standards programme is available at the IAEA Internet site http://www-ns.iaea.org/standards/ The site provides the texts in English of published and draft safety standards. The texts of safety standards issued in Arabic, Chinese, French, Russian and Spanish, the IAEA Safety Glossary and a status report for safety standards under development are also available. For further information, please contact the IAEA at P.O. Box 100, A-1400 Vienna, Austria. All users of IAEA safety standards are invited to inform the IAEA of experience in their use (e.g. as a basis for national regulations, for safety reviews and for training courses) for the purpose of ensuring that they continue to meet users’ needs. -
Of Suvranu Ganguli Supporting the Yttrium-90 Microsphere
'Page 1 of2 As of: 12/18/17 4:23 PM Received: December 17, 2017 . ' · Status: Pending_Post PUBLIC SUBMISSION Tracking No . .lkl-90ef-jm8z Comments Due: January 08, 2018 Submission Type: API Docket: NRC-2017-0215 Yttrium-90 Microsphere Brachytherapy Sources and Devices Therasphere and SIR-Spheres Comment On: NRC-2017-0215-0001 Yttrium-90 Microsphere Brachytherapy Sources and Devices TheraSphere and SIR-Spheres; Draft Guidance for Comment Document: NRC-2017-0215-DRAFT-0108 Comment on FR Doc# 2017-24129 I - -- Submitter Information /I / 1 / cJ-1)/ 7 p ~ ~A,c!J7?~-- Name: Suvranu Ganguli Address: Massachusetts General Hospital 55 Fruit Street, GRB 298 Boston, MA, 02114 Email: [email protected] Organization: Massachusetts General Hospital/Harvard Medical School General Comment Dear Nuclear Regulatory Commission, I am a practicing interventional radiologist/oncologist at Massachusetts General Hospital and an Assistant Professor of Radiology at Harvard Medical School, and have been practicing for over 8 years. I have utiilzed Y-90 radioembolization on hundreds of patients over that time, and I am an authorized used for both Sir-Spheres and Theraspheres at my hospital. I have worked closely with Sirtex for may years in treating my patients. I endorse the Sirtex response to the NRC proposed amendment, which is supplied below. Thank you for your consideration, SUNSI Review Complete Template = ADM - 013 E-RIDS= ADM -03 " https://www.fdms.gov/fdms/getcontent?objectid=0900006482< Add= A· :!);uJL/eY/ek_&eJ:t-.) 12/18/2017 Page 2 of2 Suvranu Ganguli, MD Attachments Sirtex Response to NRC Proposed Changes Oct 2016 https://www.fdms.gov/fdms/getcontent?objectid=0900006482d22499&format=xml&showorig=false 12/18/2017 SIRThX Sirtex Response to Proposed Changes to the Yttrium-90 Microsphere Brachytherapy Sources and Devices Licensing Guidance Statement to the U.S. -
Radiation Protection Guidelines for Safe Handling of Decedents
Radiation Protection Radiation Protection Guidelines for Safe Handling of Decedents REGDOC-2.7.3 June 2018 Radiation Protection Guidelines for Safe Handling of Decedents Regulatory document REGDOC-2.7.3 © Canadian Nuclear Safety Commission (CNSC) 2018 Cat. No. CC172-195/2018E-PDF ISBN 978-0-660-26930-6 Extracts from this document may be reproduced for individual use without permission provided the source is fully acknowledged. However, reproduction in whole or in part for purposes of resale or redistribution requires prior written permission from the Canadian Nuclear Safety Commission. Également publié en français sous le titre : Lignes directrices sur la radioprotection pour la manipulation sécuritaire des dépouilles Document availability This document can be viewed on the CNSC website. To request a copy of the document in English or French, please contact: Canadian Nuclear Safety Commission 280 Slater Street P.O. Box 1046, Station B Ottawa, ON K1P 5S9 CANADA Tel.: 613-995-5894 or 1-800-668-5284 (in Canada only) Fax: 613-995-5086 Email: [email protected] Website: nuclearsafety.gc.ca Facebook: facebook.com/CanadianNuclearSafetyCommission YouTube: youtube.com/cnscccsn Twitter: @CNSC_CCSN LinkedIn: linkedin.com/company/cnsc-ccsn Publishing history June 2018 Version 1.0 June 2018 REGDOC-2.7.3, Radiation Protection Guidelines for Safe Handling of Decedents Preface This regulatory document is part of the CNSC’s radiation protection series of regulatory documents. The full list of regulatory document series is included at the end of this document and can also be found on the CNSC’s website. Many medical procedures using nuclear substances are carried out to diagnose and treat diseases.