Addressing Synthetic and Designer Drugs in Adult Court

Total Page:16

File Type:pdf, Size:1020Kb

Addressing Synthetic and Designer Drugs in Adult Court ISSUE BRIEF A CHALLENGING DESIGN: ADDRESSING SYNTHETIC AND DESIGNER DRUGS INTRODUCTION Over the last decade, the prevalence of synthetic and designer IN ADULT COURTS drugs has increased at alarming rates. The European Monitor - ing Centre for Drugs and Addiction identified thirteen new By: Blaine Stum psychoactive substances (NPSs) in 2008 and ninety-eight NPSs in 2015, a 653 percent increase in only seven years. 1 A total of 480 NPSs were identified during that time frame. NOVEMBER 2016 This surge in availability, along with reported increases in use, difficulties associated with detection of emerging synthetic and designer drugs, and a murky legal landscape create myriad challenges for drug court practitioners and substance abuse treatment organizations. The National Drug Court Resource Center Number of New Psychoactive Substances By Year (NDCRC) is housed at the Justice Programs 120 101 100 98 Office, a center in American University’s 81 80 73 60 49 School of Public Affairs, and is funded by 41 40 24 the Bureau of Justice Assistance. Issue 20 13 0 briefs, such as this, are created to educate 2008 2009 2010 2011 2012 2013 2014 2015 Source: European Monitoring Centre for Drugs and Drug Addiction and inform the treatment court field about topics of importance. For more information LEGAL STATUS Currently, there are two laws that specifically address synthetic please visit the National Drug Court or designer drugs: Resource Center at www.ndcrc.org. 1) The Federal Analogue Act (21 U.S.C. § 813) 2) The Synthetic Drug Abuse Prevention Act (21 U.S.C .812(c)) The Federal Analogue Act was passed by Congress in 1986. AMERICAN UNIVERSITY’S SCHOOL OF PUBLIC AFFAIRS The bill amended the Controlled Substances Act (21U.S.C. The Justice Programs Office, a center in American University’s §801 et. Seq) so that synthetic or designer drugs that are School of Public Affairs, supports the National Drug Court Resource “substantially similar” to drugs already on Schedule I or II are Center, part of a BJA-funded drug court initiative. This issue brief treated the same as those controlled substances. 2 was created to respond to significant issues identified during the provision of technical assistance to the field. For more information about accessing technical assistance services or to learn more about the AU Justice Programs Office, go to www.american.edu/justice. 2 ADDRESSING SYNTHETIC AND DESIGNER DRUGS IN ADULT COURT INCIDENCE OF USE To better understand populations that are at risk for synthetic drug use, researchers have surveyed a variety of groups during the last several years. In general, these surveys show that synthetic cannabinoids are the most widely abused synthetic drug. The Monitoring the Future Survey, for instance, found that ten percent of high school seniors reported using synthetic cannabinoids in the previous year, compared to 1.1 percent of high school seniors who reported using synthetic cathinones in the previous year. 10 Use rates fluctuate depending on the popula - tion being surveyed however; and survey literature does not suggest that synthetic or The Synthetic Drug Abuse Prevention Act substance analogue shall, to the extent designer drugs are “drugs of choice” for most was passed by Congress in 2012. It added intended for human consumption, be treated, users. Below is a sampling of studies on “cannabimimetic agents” to Schedule I of for purposes of this title and title III as a synthetic drug use: the Controlled Substances Act, as well as controlled substance in schedule I.” 6 Packages fifteen specific cannabinoid compounds and of synthetic cannabinoids, bath salts, and • A survey of current cannabis users by eleven synthetic stimulants and hallucino - other synthetic drugs will often have warnings Gunderson, et al. found that twenty-four gens. 3 on them that state “Not Intended for percent of respondents reported currently using synthetic cannabinoids. 11 This sug - In addition to these laws, the United States Human Consumption” as a way to exploit this gests that current cannabis users are more Attorney General (AG) possesses the authority language. likely to be using synthetic cannabinoids. to temporarily list a substance under Schedule FORM AND MODES OF I if such an action is “necessary to avoid an ADMINISTRATION • Wagner et al. found that seven percent of 4 injection drug users reported using imminent hazard to the public health.” Of Synthetic cannabinoids are man-made synthetic cathinones. 12 the thirty-seven times this authority has been chemicals that are functionally similar asserted by the AG, thirty-two have been to Δ9- tetrahydrocannabinol (THC), the • Caban et al. surveyed 155 army patients at 5 within the last five years. psychoactive constituent found in cannabis. Fort Bragg, North Carolina, who admitted Despite these laws and actions, sellers and These chemicals are either sprayed on dry or were suspected of using an illegal users of synthetic drugs have been able to plant materials for users to smoke or sold as substance. Tests revealed that 7.7 percent advertise these drugs as “legal highs” because liquids for vaporizing in e-cigarette devices. had recently used spice. 13 of language in Section 203 of the Federal Synthetic cathinones, also known as “bath Two studies of synthetic cannabinoid use have Analogue Act. It states that “a controlled salts,” are a class of drugs that are chemically specifically surveyed criminal justice popula - related to the khat plant found in Southern tions: The Community Drug Early Warning Synthetic Drugs Arabia and East Africa. They usually take the System (CDEWS) Pilot Project in 2013, and a CDEWS replication study conducted two Substances wherein the form of white or brown crystal-like powder that can be snorted, ingested, smoked or years later. psychoactive properties of a injected. 7 Similarly, non-pharmaceutical In both studies, researchers tested urine scheduled drug have been fentanyl, a potent opioid, comes in powder or samples that were previously tested using a tablet form, that users can snort, ingest, or standard drug testing panel with an expanded retained, but the molecular inject. 8 drug panel. The results suggest that synthetic structure has been altered in Kratom comes from the plant Mitragyna cannabinoid use is relatively frequent. In the speciosa Korth. Kratom users chew the leaves pilot project study, they found that thirty-nine order to avoid prosecution or gum infused with kratom or brew dried percent of urine specimens from parolees and under the Controlled kratom leaves or powder in a tea. 9 Kratom is probationers in Washington, DC, whose not a synthetic drug, but due to increased standard drug test was negative tested positive Substances Act. use and awareness of kratom in the U.S. for synthetic cannabinoids. 14 The expanded D.E. Smith and R.B. Seymour, 1985 researchers have used the label “designer sample used in the replication study produced drug,” which is why it is included here. similar results, finding that thirty-six percent For more information: [email protected], 202.885.2875, www.american.edu/justice 3 of parolee and probationer urine samples who endorsed using spice products to “achieve fully known at this time, 23 although some tested negative under a standard panel tested intoxication while avoiding detection in drug research suggests that low doses produce positive for synthetic cannabinoids. 15 urinalysis testing.” 19 stimulant-like effects, while high doses can 24 The replication study also obtained urine EFFECTS AND HEALTH IMPACTS mimic the effects of opioids. specimens from an adult drug court in Denver, The short-and-medium term effects of using Colorado, and found that three percent of synthetic cannabinoids, bath salts, fentanyl, specimens who tested negative under the Emergency Department Visits and kratom manifest in a variety of ways that Involving Synthetic Cannabinoids standard panel tested positive for synthetic drug court programs should be on the lookout 16 cannabinoids. for: 30,000 What factors influence the decision to use Synthetic cannabinoids: Use of synthetic 25,000 synthetic drugs? No doubt the costs, increased cannabinoids may have similar effects as 17 20,000 availability, and legal ambiguity play a role. cannabis use, although the effects are less But surveys have also found that many people predictable. 20 Users can exhibit sedation, 15,000 use synthetic drugs to specifically avoid paranoia, anxiety, confusion, and delusions. 21 detection. Bonar, Ashrafioun, and Ilgen found 10,000 Bath salts: These drugs produce effects akin that seventy-one percent of patents in residen - 5,000 tial treatment facility used synthetic cannabi - to methamphetamine use, such as hyperactiv - noids to “get high without having a positive ity, euphoria, anxiety, confusion, suicidal 0 22 2010 2011 drug test.” 18 Another survey (Vandery et al.) thoughts, and weight loss. Kratom: The exact effects of kratom use on of people who reported using spice at least Source: Drug Abuse Warning Network. once in their life found that thirty percent the behavior and health of humans are not WHAT CAN DRUG COURTS DO? thetic drugs are often used to avoid detection in standard drug tests (Perone et al.), 30 drug Communicate with law enforcement, emer - • Testing should be frequent, random, and courts should consider sanctions that address gency departments, and treatment facilities. test for possible dilution or adulteration. two behaviors: the use of the synthetic drug in question and the potential effort to deceive the They may be able to share information on • Results should be available within forty- court. 31 what synthetic and designer drugs are most eight hours of sample collection. commonly used in the area, or specific drugs Utilize random searches and seizures. Before Conduct drug tests with extended panels. that are emerging. Drug courts may also using this strategy, drug courts should make Some companies are beginning to release consider scouting local head shops to see what sure they understand all applicable laws expanded panel tests, but the costs are often drugs are being sold.
Recommended publications
  • 3,4-Methylenedioxymethcathinone (Methylone) [“Bath Salt,” Bk-MDMA, MDMC, MDMCAT, “Explosion,” “Ease,” “Molly”] December 2019
    Drug Enforcement Administration Diversion Control Division Drug & Chemical Evaluation Section 3,4-Methylenedioxymethcathinone (Methylone) [“Bath salt,” bk-MDMA, MDMC, MDMCAT, “Explosion,” “Ease,” “Molly”] December 2019 Introduction: discriminate DOM from saline. 3,4-Methylenedioxymethcathinone (methylone) is a Because of the structural and pharmacological similarities designer drug of the phenethylamine class. Methylone is a between methylone and MDMA, the psychoactive effects, adverse synthetic cathinone with substantial chemical, structural, and health risks, and signs of intoxication resulting from methylone pharmacological similarities to 3,4-methylenedioxymeth- abuse are likely to be similar to those of MDMA. Several chat amphetamine (MDMA, ecstasy). Animal studies indicate that rooms discussed pleasant and positive effects of methylone when methylone has MDMA-like and (+)-amphetamine-like used for recreational purpose. behavioral effects. When combined with mephedrone, a controlled schedule I substance, the combination is called User Population: “bubbles.” Other names are given in the above title. Methylone, like other synthetic cathinones, is a recreational drug that emerged on the United States’ illicit drug market in 2009. It is perceived as being a ‘legal’ alternative to drugs of Licit Uses: Methylone is not approved for medical use in the United abuse like MDMA, methamphetamine, and cocaine. Evidence States. indicates that youths and young adults are the primary users of synthetic cathinone substances which include methylone. However, older adults also have been identified as users of these Chemistry: substances. O H O N CH3 Illicit Distribution: CH O 3 Law enforcement has encountered methylone in the United States as well as in several countries including the Netherlands, Methylone United Kingdom, Japan, and Sweden.
    [Show full text]
  • Frequently Asked Questions About Synthetic Drugs
    FREQUENTLY ASKED QUESTIONS ABOUT SYNTHETIC DRUGS WHAT ARE SYNTHETIC DRUGS? WHAT DOES THE PACKAGING OF SYNTHETIC CANNABINOIDS LOOK LIKE? A SYNTHETIC DRUG, ALSO REFERRED TO AS A Many of the products are sold in colorful packets with names DESIGNER DRUG, IS A CHEMICAL INTENDED TO that appeal to adolescents and young adults. Manufacturers IMITATE THE PROPERTIES AND EFFECTS OF A label the packages as “not for human consumption” and KNOWN HALLUCINOGEN OR NARCOTIC AND market the products as incense or potpourri to mask the MAY HAVE UNKNOWN SIDE EFFECTS OR CAUSE intended purpose and to avoid regulatory oversight of AN ADVERSE REACTION. THESE DRUGS ARE the manufacturing process. You can view examples of the packaging on page 3. CREATED IN ORDER TO EVADE RESTRICTIONS AGAINST ILLEGAL SUBSTANCES. ARE SYNTHETIC CANNABINOIDS ARE SYNTHETIC DRUGS LEGAL IN TEXAS? DANGEROUS? No. Under state law, it is a crime to manufacture, deliver or Synthetic cannabinoids possess a synthetic drug. are illegal, dangerous, highly addictive and WHAT ARE SYNTHETIC CANNABINOIDS? potentially deadly. One Synthetic cannabinoids are commonly referred to as K2, of the original chemists Kush, Spice, synthetic marijuana and fake weed. They are who designed synthetic a mix of plant matter sprayed with chemicals in sometimes cannabis for research purposes, John Huffman, Ph.D., likened dangerously high proportions, falsely marketed as “legal recreational use of synthetic drugs to playing Russian highs” and smoked like marijuana. roulette. The contents and effects of synthetic cannabinoids WHERE ARE SYNTHETIC CANNABINOIDS SOLD? are unpredictable due to a constantly changing variety of Synthetic cannabinoids are relatively inexpensive and sold chemicals used in manufacturing processes devoid of quality in convenience stores, smoke shops, novelty stores, on the controls and government regulatory oversight.
    [Show full text]
  • Ce4less.Com Ce4less.Com Ce4less.Com Ce4less.Com Ce4less.Com Ce4less.Com Ce4less.Com
    Hallucinogens And Dissociative Drug Use And Addiction Introduction Hallucinogens are a diverse group of drugs that cause alterations in perception, thought, or mood. This heterogeneous group has compounds with different chemical structures, different mechanisms of action, and different adverse effects. Despite their description, most hallucinogens do not consistently cause hallucinations. The drugs are more likely to cause changes in mood or in thought than actual hallucinations. Hallucinogenic substances that form naturally have been used worldwide for millennia to induce altered states for religious or spiritual purposes. While these practices still exist, the more common use of hallucinogens today involves the recreational use of synthetic hallucinogens. Hallucinogen And Dissociative Drug Toxicity Hallucinogens comprise a collection of compounds that are used to induce hallucinations or alterations of consciousness. Hallucinogens are drugs that cause alteration of visual, auditory, or tactile perceptions; they are also referred to as a class of drugs that cause alteration of thought and emotion. Hallucinogens disrupt a person’s ability to think and communicate effectively. Hallucinations are defined as false sensations that have no basis in reality: The sensory experience is not actually there. The term “hallucinogen” is slightly misleading because hallucinogens do not consistently cause hallucinations. 1 ce4less.com ce4less.com ce4less.com ce4less.com ce4less.com ce4less.com ce4less.com How hallucinogens cause alterations in a person’s sensory experience is not entirely understood. Hallucinogens work, at least in part, by disrupting communication between neurotransmitter systems throughout the body including those that regulate sleep, hunger, sexual behavior and muscle control. Patients under the influence of hallucinogens may show a wide range of unusual and often sudden, volatile behaviors with the potential to rapidly fluctuate from a relaxed, euphoric state to one of extreme agitation and aggression.
    [Show full text]
  • GHB, GBL & Related Compounds: Literature Review
    ACMD Advisory Council on the Misuse of Drugs An assessment of the harms of gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL), and closely related compounds November 2020 1 Contents 1. Introduction ................................................................................................................................... 4 2. Previous ACMD advice and legal status of GHBRS- UK ..................................................... 5 3. Chemistry and pharmacology ................................................................................................... 7 GHB ................................................................................................................................................... 7 GBL.................................................................................................................................................... 8 1,4-BD ............................................................................................................................................... 8 GHV/GVL .......................................................................................................................................... 9 4. Therapeutic and other legitimate uses of GHBRS ............................................................... 10 Therapeutic uses ........................................................................................................................... 10 Industrial/commercial uses .........................................................................................................
    [Show full text]
  • Question of the Day Archives: Monday, December 5, 2016 Question: Calcium Oxalate Is a Widespread Toxin Found in Many Species of Plants
    Question Of the Day Archives: Monday, December 5, 2016 Question: Calcium oxalate is a widespread toxin found in many species of plants. What is the needle shaped crystal containing calcium oxalate called and what is the compilation of these structures known as? Answer: The needle shaped plant-based crystals containing calcium oxalate are known as raphides. A compilation of raphides forms the structure known as an idioblast. (Lim CS et al. Atlas of select poisonous plants and mushrooms. 2016 Disease-a-Month 62(3):37-66) Friday, December 2, 2016 Question: Which oral chelating agent has been reported to cause transient increases in plasma ALT activity in some patients as well as rare instances of mucocutaneous skin reactions? Answer: Orally administered dimercaptosuccinic acid (DMSA) has been reported to cause transient increases in ALT activity as well as rare instances of mucocutaneous skin reactions. (Bradberry S et al. Use of oral dimercaptosuccinic acid (succimer) in adult patients with inorganic lead poisoning. 2009 Q J Med 102:721-732) Thursday, December 1, 2016 Question: What is Clioquinol and why was it withdrawn from the market during the 1970s? Answer: According to the cited reference, “Between the 1950s and 1970s Clioquinol was used to treat and prevent intestinal parasitic disease [intestinal amebiasis].” “In the early 1970s Clioquinol was withdrawn from the market as an oral agent due to an association with sub-acute myelo-optic neuropathy (SMON) in Japanese patients. SMON is a syndrome that involves sensory and motor disturbances in the lower limbs as well as visual changes that are due to symmetrical demyelination of the lateral and posterior funiculi of the spinal cord, optic nerve, and peripheral nerves.
    [Show full text]
  • Controlled Drug Schedules, Violations & Penalties
    CONTROLLED DRUG SCHEDULES, VIOLATIONS & PENALTIES A REFERENCE FOR THE LAW ENFORCEMENT COMMUNITY April 2015 Prepared by the DEPARTMENT OF CONSUMER PROTECTION Drug Control Division TABLE OF CONTENTS SECTION I CONTROLLED DRUG SCHEDULES & VIOLATIONS An alphabetical listing of controlled drugs by their brand, generic and/or street name that includes each drug’s schedule and the violation(s) from the Connecticut General Statutes (CGS) that are associated with each drug’s sale and/or possession. SECTION II CONTROLLED DRUG VIOLATIONS & PENALTIES A numerical listing of controlled drug violations by their section number in the Connecticut General Statutes (CGS) and the penalty(ies) associated with each violation. SECTION III SUMMARY OF FEDERAL METHAMPHETAMINE STATUTES 2 S E C T I O N I CONTROLLED DRUG SCHEDULES & VIOLATIONS The ‘Schedules of Controlled Substances’ may be found in Sections 21a-243-7 through 21a-243-11, inclusive, of the Regulations of Connecticut State Agencies. www.ct.gov/dcp/lib/dcp/dcp_regulations/21a-243_designation_of_controlled_drugs.pdf 3 Drug State CS Drug Type AKA Sale or Quantity Person Drug- CGS Schedule Possession? Dependent or Not Violation APAP = Acetaminophen APAP = Acetaminophen Drug-Dependent ? ASA = Aspirin ASA = Aspirin “2C-C” Designer Drug - Stimulant “Bath Salts” Federal CS Schedule 1 “2C-D” Designer Drug - Stimulant “Bath Salts” Federal CS Schedule 1 “2C-E” Designer Drug - Stimulant “Bath Salts” Federal CS Schedule 1 “2C-H” Designer Drug - Stimulant “Bath Salts” Federal CS Schedule 1 “2C-I” Designer Drug - Stimulant
    [Show full text]
  • New Psychoactive Substances (NPS): Factsheet
    New psychoactive substances (NPS): factsheet Who is this factsheet for? classified by the Misuse of Drugs Act 1971. This This factsheet is aimed at professionals who do means they are illegal. Possession or supply can not work specifically in the drugs field, but who carry a prison sentence. As new drugs are being may encounter substance misuse as part of developed all the time, it has proved a challenge their role and who need information on current to keep up with them using this law. The UK substance misuse issues. It may also be of government responded to this by bringing in a interest to the general public. new law, the Psychoactive Substances Act 2016. What are ‘new psychoactive This law, which came into effect on 26 May substances’? 2016, covers all psychoactive substances which are NOT already classified under the Misuse of ‘New psychoactive substances’ (NPS) is an Drugs Act 1971. The Psychoactive Substances umbrella term used to cover a wide range of Act 2016 says that possessing with intent to substances with a number of things in common: supply, supplying or offering to supply, producing, importing or exporting any psychoactive • they are psychoactive (they affect the user’s substance, all carry a penalty of up to seven years mental functioning or emotional state by and/or a fine, depending on the seriousness of stimulating or depressing the central nervous the offence. This means that it is against system (brain and spinal cord)); the law to supply anyone with one of these substances. • they are newly available in the UK or have seen a recent increase in popularity and public Possession of a psychoactive substance is not awareness; an offence and carries no penalty.
    [Show full text]
  • Enantioseparation and Determination of Mephedrone and Its Metabolites by Capillary Electrophoresis Using Cyclodextrins As Chiral Selectors
    molecules Article Enantioseparation and Determination of Mephedrone and Its Metabolites by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors Pavel Rezankaˇ 1,* , Denisa Macková 1, Radek Jurok 2,3, Michal Himl 3 and Martin Kuchaˇr 2 1 Department of Analytical Chemistry, Faculty of Chemical Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic; [email protected] 2 Department of Chemistry of Natural Compounds, Forensic Laboratory of Biologically Active Substances, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic; [email protected] (R.J.); [email protected] (M.K.) 3 Department of Organic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic; [email protected] * Correspondence: [email protected] Academic Editor: Estrella Núñez Delicado Received: 25 May 2020; Accepted: 19 June 2020; Published: 23 June 2020 Abstract: Mephedrone, a psychoactive compound derived from cathinone, is widely used as a designer drug. The determination of mephedrone and its metabolites is important for understanding its possible use in medicine. In this work, a method of capillary electrophoresis for the chiral separation of mephedrone and its metabolites was developed. Carboxymethylated β-cyclodextrin was selected as the most effective chiral selector from seven tested cyclodextrin derivates. Based on the simplex method, the optimal composition of the background electrolyte was determined: at pH 2.75 and 7.5 mmol L 1 carboxymethylated β-cyclodextrin the highest total resolution of a mixture of analytes · − was achieved. For mephedrone and its metabolites, calibration curves were constructed in a calibration range from 0.2 to 5 mmol L 1; limits of detection, limits of quantification, precision, and repeatability · − were calculated, and according to Mandel’s fitting test, the linear calibration ranges were determined.
    [Show full text]
  • The Designer Methcathinone Analogs, Mephedrone and Methylone, Are Substrates for Monoamine Transporters in Brain Tissue
    Neuropsychopharmacology (2012) 37, 1192–1203 & 2012 American College of Neuropsychopharmacology. All rights reserved 0893-133X/12 www.neuropsychopharmacology.org The Designer Methcathinone Analogs, Mephedrone and Methylone, are Substrates for Monoamine Transporters in Brain Tissue ,1 1 1 1 2 Michael H Baumann* , Mario A Ayestas Jr , John S Partilla , Jacqueline R Sink , Alexander T Shulgin , 2 3 1 4 5 Paul F Daley , Simon D Brandt , Richard B Rothman , Arnold E Ruoho and Nicholas V Cozzi 1 Translational Pharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, 2 3 MD, USA; Alexander Shulgin Research Institute, Lafayette, CA, USA; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores 4 University, Liverpool, UK; Department of Neuroscience and the UW Eye Research Institute, University of Wisconsin School of Medicine and 5 Public Health, Madison, WI, USA; Neuropharmacology Laboratory, Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA The nonmedical use of ‘designer’ cathinone analogs, such as 4-methylmethcathinone (mephedrone) and 3,4-methylenedioxymethcathi- none (methylone), is increasing worldwide, yet little information is available regarding the mechanism of action for these drugs. Here, we employed in vitro and in vivo methods to compare neurobiological effects of mephedrone and methylone with those produced by the structurally related compounds, 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine. In vitro release assays using rat brain synaptosomes revealed that mephedrone and methylone are nonselective substrates for plasma membrane monoamine transporters, similar to MDMA in potency and selectivity. In vivo microdialysis in rat nucleus accumbens showed that i.v.
    [Show full text]
  • Drugs and New Potentially Dangerous Chemical Substances, with a Brief Review of the Problem
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL & SCIENCE EDUCATION 2016, VOL. 11, NO. 14, 6697-6703 OPEN ACCESS Approach to Classifying “Design” Drugs and New Potentially Dangerous Chemical Substances, With a Brief Review of the Problem Azat R. Asadullina, Elena Kh. Galeevab, Elvina A. Achmetovaa and Ivan V. Nikolaevb aBashkir State Medical University of the Ministry of Health of the Russian Federation, Ufa, RUSSIA; bRepublican Narcological Dispensary No.1 of the Ministry of Health of the Republic of Bashkortostan, Ufa, RUSSIA ABSTRACT The urgency of this study has become vivid in the light of the growing problem of prevalence and bBPHFuse Republican of new synthetic Narcological drug types. DispensaryLately there has No.1 been of a thetendency Ministry of expanding of Health the rangeof the of psychologically active substances (PAS) used by addicts with the purpose of their illegal taking. RepublicThe aim of Bashkortostan,of this research is anPushkin attempt str.,of systematizing 119/1, Ufa, and RB. classifying “design” drugs according to their chemical structure, neurochemical mechanisms of action and clinical manifestations. As a result, we have found that they can be divided into ten big groups. This classification will allow to better arrange new clinical phenomenology in modern addictology. This paper would be useful for psychiatrists, experts in narcology, as well as for personnel of institutions and agencies engaged in anti-drug activity. KEYWORDS ARTICLE HISTORY Opiates, cannabinoids, cathinones, tryptamine, Received 20 April 2016 cocaine, pregabalin, new “design” drugs, Revised 28 May 2016 classification Accepted 29 Мау 2016 Introduction Urgency of the problem Recently, the sphere of illegal turnover of narcotic substances has shown an apparent trend of producing the so-called “design drugs” (DN): new potentially dangerous psychologically active substances (NPDPAS) obtained by means of chemical synthesis, possessing a high narcotic effect and manufactured with the CORRESPONDENCE Azat R.
    [Show full text]
  • Bath Salt-Type Aminoketone Designer Drugs: Analytical and Synthetic Studies on Substituted Cathinones
    The author(s) shown below used Federal funds provided by the U.S. Department of Justice and prepared the following final report: Document Title: Bath Salt-type Aminoketone Designer Drugs: Analytical and Synthetic Studies on Substituted Cathinones Author(s): Randall Clark, Ph.D. Document No.: 250125 Date Received: July 2016 Award Number: 2013-DN-BX-K022 This report has not been published by the U.S. Department of Justice. To provide better customer service, NCJRS has made this federally funded grant report available electronically. Opinions or points of view expressed are those of the author(s) and do not necessarily reflect the official position or policies of the U.S. Department of Justice. Final Summary Overview, NIJ award 2013-DN-BX-K022 Bath Salt-type Aminoketone Designer Drugs: Analytical and Synthetic Studies on Substituted Cathinones Purpose of Project: This project has focused on issues of resolution and discriminatory capabilities in controlled substance analysis providing data to increase reliability and selectivity for forensic evidence and analytical data on new analytes of the so-called bath salt-type drugs of abuse. The overall goal of these studies is to provide an analytical framework for the identification of individual substituted cathinones to the exclusion of all other possible isomeric and homologous forms of these compounds. A number of aminoketones or beta-keto/benzylketo compounds (bk-amines) have appeared on the illicit drug market in recent years including methcathinone, mephedrone, methylone and MDPV (3,4-methylenedioxypyrovalerone). These substances represent a variety of aromatic ring substituent, hydrocarbon side chain and amino group modifications of the basic cathinone/methcathinone molecular skeleton.
    [Show full text]
  • Mephedrone Monograph
    SOFT Designer Drug Committee Monographs vers. 1.1 9/13/2013 Emerging Designer Drug Monograph Revision Date: July 22, 2013 Author(s): Elizabeth Schlatter, Barry K. Logan Drug Name: Mephedrone Synonyms: 4-Methylmethcathinone, 4-MeMC, 4-Methylephedrone, 4-MMC, 2-aminomethyl-1- tolyl-propan- 1-one Structure: O CH3 HN H3C CH 3 Formula: C11H15NO Molecular Weight: 177.2 Pharmacological Drug Class: CNS Stimulant that initiates catecholamine release and inhibits monoamine oxidase, increasing concentrations of serotonin, norepinephrine, and dopamine in the synaptic cleft (1). Metabolism: Mephedrone is N-demethylated to a primary amine metabolite. Ketone groups are reduced to alcohols (1). Blood Concentrations: Case studies outlined by Maskell et al (2011) report plasma mephedrone concentrations of 0.15mg/L in a non-fatal intoxication. In a case involving multiple drug toxicity mephedrone blood concentration was 0.5mg/L (2,3). Adamowicz (2013) reports fatal mephedrone concentrations range of 5.5 µg/mL in the blood and 7.1 µg/mL in the vitreous humor (4). Effects and Toxicity: Mephedrone is a synthetic cathinone derivative that has stimulant effects similar to methamphetamine, ecstasy, and cocaine (3). Effects include increased alertness, tachycardia, sweating, and insomnia (5). Additionally, users describe feelings of empathy and euphoria (see www.erowid.org). Analysis: Mephedrone is a small, basic drug that chromatographs well through GC-MS. See SWGDRUG Monograph for GC-MS method and sample chromatographs. Dickson et al (2010) collected data at a mass range if 42-550, using a SIM method targeting m/z 204, 160, 119. Extractions and GC-MS method parameters are outlined (3).
    [Show full text]