Neural Mechanisms of Navigation Involving Interactions of Cortical and Subcortical Structures
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Reversible Verbal and Visual Memory Deficits After Left Retrosplenial Infarction
Journal of Clinical Neurology / Volume 3 / March, 2007 Case Report Reversible Verbal and Visual Memory Deficits after Left Retrosplenial Infarction Jong Hun Kim, M.D.*, Kwang-Yeol Park, M.D.†, Sang Won Seo, M.D.*, Duk L. Na, M.D.*, Chin-Sang Chung, M.D.*, Kwang Ho Lee, M.D.*, Gyeong-Moon Kim, M.D.* *Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea †Department of Neurology, Chung-Ang University Medical Center, Chung-Ang University School of Medicine, Seoul, Korea The retrosplenial cortex is a cytoarchitecturally distinct brain structure located in the posterior cingulate gyrus and bordering the splenium, precuneus, and calcarine fissure. Functional imaging suggests that the retrosplenium is involved in memory, visuospatial processing, proprioception, and emotion. We report on a patient who developed reversible verbal and visual memory deficits following a stroke. Neuro- psychological testing revealed both anterograde and retrograde memory deficits in verbal and visual modalities. Brain diffusion-weighted and T2-weighted magnetic resonance imaging (MRI) demonstrated an acute infarction of the left retrosplenium. J Clin Neurol 3(1):62-66, 2007 Key Words : Retrosplenium, Memory, Amnesia We report on a patient who developed both verbal INTRODUCTION and visual memory deficits after an acute infarction of the retrosplenial cortex. The main structures related to human memory are the Papez circuit, the basolateral limbic circuit, and the basal forebrain, which communicate with each other through white-matter tracts. Damage to these structures (in- cluding the communication tracts) from hemorrhages, infarctions, and tumors can result in memory dis- turbances.1,2 In addition to these structures, Valenstein et al. -
Changing the Cortical Conductor's Tempo: Neuromodulation of the Claustrum
REVIEW published: 13 May 2021 doi: 10.3389/fncir.2021.658228 Changing the Cortical Conductor’s Tempo: Neuromodulation of the Claustrum Kelly L. L. Wong 1, Aditya Nair 2,3 and George J. Augustine 1,2* 1Neuroscience and Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore, 2Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore, 3Computation and Neural Systems, California Institute of Technology, Pasadena, CA, United States The claustrum is a thin sheet of neurons that is densely connected to many cortical regions and has been implicated in numerous high-order brain functions. Such brain functions arise from brain states that are influenced by neuromodulatory pathways from the cholinergic basal forebrain, dopaminergic substantia nigra and ventral tegmental area, and serotonergic raphe. Recent revelations that the claustrum receives dense input from these structures have inspired investigation of state-dependent control of the claustrum. Here, we review neuromodulation in the claustrum—from anatomical connectivity to behavioral manipulations—to inform future analyses of claustral function. Keywords: claustrum, acetylcholine, serotonin, dopamine, neuromodulation Edited by: Edouard Pearlstein, INTRODUCTION Independent Researcher, Marseille, France The claustrum is a long and irregular sheet of neurons nestled between the insula and striatum. As it is known to be heavily and bilaterally connected to many brain regions in organisms ranging Reviewed by: Ami Citri, from mice to humans (Sherk, 1986; Torgerson et al., 2015; Wang et al., 2017, 2019; Zingg et al., Hebrew University of Jerusalem, 2018), the claustrum has been likened to a cortical conductor (Crick and Koch, 2005). -
Retrosplenial Cortex Is Necessary for Latent Learning in Mice
bioRxiv preprint doi: https://doi.org/10.1101/2021.07.21.453258; this version posted July 23, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Retrosplenial cortex is necessary for spatial and non-spatial latent learning in mice Ana Carolina Bottura de Barros1,2*, Liad J. Baruchin1#, Marios C. Panayi3#, Nils Nyberg1, Veronika Samborska1, Mitchell T. Mealing1, Thomas Akam3, Jeehyun Kwag4, David M. Bannerman3 & Michael M. Kohl1,2* 1 Dept. of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK 2 Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, G12 8QQ, UK 3 Dept. of Experimental Psychology, University of Oxford, Oxford, OX1 3SR, UK 4 Dept. of Brain and Cognitive Engineering, Korea University, Seoul, 136-71, Republic of Korea #These authors contributed equally *Correspondence: [email protected] & [email protected] Keywords: Latent Learning, Retrosplenial Cortex, Optogenetics, Internal Model, Mice 1/19 bioRxiv preprint doi: https://doi.org/10.1101/2021.07.21.453258; this version posted July 23, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 Abstract 2 Latent learning occurs when associations are formed between stimuli in the absence of explicit 3 reinforcement. -
The Pre/Parasubiculum: a Hippocampal Hub for Scene- Based Cognition? Marshall a Dalton and Eleanor a Maguire
Available online at www.sciencedirect.com ScienceDirect The pre/parasubiculum: a hippocampal hub for scene- based cognition? Marshall A Dalton and Eleanor A Maguire Internal representations of the world in the form of spatially which posits that one function of the hippocampus is to coherent scenes have been linked with cognitive functions construct internal representations of scenes in the ser- including episodic memory, navigation and imagining the vice of memory, navigation, imagination, decision-mak- future. In human neuroimaging studies, a specific hippocampal ing and a host of other functions [11 ]. Recent inves- subregion, the pre/parasubiculum, is consistently engaged tigations have further refined our understanding of during scene-based cognition. Here we review recent evidence hippocampal involvement in scene-based cognition. to consider why this might be the case. We note that the pre/ Specifically, a portion of the anterior medial hippocam- parasubiculum is a primary target of the parieto-medial pus is consistently engaged by tasks involving scenes temporal processing pathway, it receives integrated [11 ], although it is not yet clear why a specific subre- information from foveal and peripheral visual inputs and it is gion of the hippocampus would be preferentially contiguous with the retrosplenial cortex. We discuss why these recruited in this manner. factors might indicate that the pre/parasubiculum has privileged access to holistic representations of the environment Here we review the extant evidence, drawing largely from and could be neuroanatomically determined to preferentially advances in the understanding of visuospatial processing process scenes. pathways. We propose that the anterior medial portion of the hippocampus represents an important hub of an Address extended network that underlies scene-related cognition, Wellcome Trust Centre for Neuroimaging, Institute of Neurology, and we generate specific hypotheses concerning the University College London, 12 Queen Square, London WC1N 3BG, UK functional contributions of hippocampal subfields. -
Interpreting Zheng Chenggong: the Politics of Dramatizing
, - 'I ., . UN1VERSIlY OF HAWAII UBRARY 3~31 INTERPRETING ZHENG CHENGGONG: THE POLITICS OF DRAMATIZING A HISTORICAL FIGURE IN JAPAN, CHINA, AND TAIWAN (1700-1963) A THESIS SUBMITTED TO THE GRADUATE DIVISION OF THE UNIVERSITY OF HAW AI'I IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF ARTS IN THEATRE AUGUST 2007 By Chong Wang Thesis Committee: Julie A. Iezzi, Chairperson Lurana D. O'Malley Elizabeth Wichmann-Walczak · - ii .' --, L-' ~ J HAWN CB5 \ .H3 \ no. YI,\ © Copyright 2007 By Chong Wang We certity that we have read this thesis and that, in our opinion, it is satisfactory in scope and quality as a thesis for the degree of Master of Arts in Theatre. TIIESIS COMMITTEE Chairperson iii ACKNOWLEDGEMENTS I want to give my wannest thanks to my family for their strong support. I also want to give my since're thanks to Dr. Julie Iezzi for her careful guidance and tremendous patience during each stage of the writing process. Finally, I want to thank my proofreaders, Takenouchi Kaori and Vance McCoy, without whom this thesis could not have been completed. - . iv ABSTRACT Zheng Chenggong (1624 - 1662) was sired by Chinese merchant-pirate in Hirado, Nagasaki Prefecture, Japan. A general at the end of the Chinese Ming Dynasty, he was a prominent leader of the movement opposing the Manchu Qing Dynasty, and in recovering Taiwan from Dutch colonial occupation in 1661. Honored as a hero in Japan, China, and Taiwan, he has been dramatized in many plays in various theatre forms in Japan (since about 1700), China (since 1906), and Taiwan (since the 1920s). -
Default Mode Network in Childhood Autism Posteromedial Cortex Heterogeneity and Relationship with Social Deficits
ARCHIVAL REPORT Default Mode Network in Childhood Autism: Posteromedial Cortex Heterogeneity and Relationship with Social Deficits Charles J. Lynch, Lucina Q. Uddin, Kaustubh Supekar, Amirah Khouzam, Jennifer Phillips, and Vinod Menon Background: The default mode network (DMN), a brain system anchored in the posteromedial cortex, has been identified as underconnected in adults with autism spectrum disorder (ASD). However, to date there have been no attempts to characterize this network and its involvement in mediating social deficits in children with ASD. Furthermore, the functionally heterogeneous profile of the posteromedial cortex raises questions regarding how altered connectivity manifests in specific functional modules within this brain region in children with ASD. Methods: Resting-state functional magnetic resonance imaging and an anatomically informed approach were used to investigate the functional connectivity of the DMN in 20 children with ASD and 19 age-, gender-, and IQ-matched typically developing (TD) children. Multivariate regression analyses were used to test whether altered patterns of connectivity are predictive of social impairment severity. Results: Compared with TD children, children with ASD demonstrated hyperconnectivity of the posterior cingulate and retrosplenial cortices with predominately medial and anterolateral temporal cortex. In contrast, the precuneus in ASD children demonstrated hypoconnectivity with visual cortex, basal ganglia, and locally within the posteromedial cortex. Aberrant posterior cingulate cortex hyperconnectivity was linked with severity of social impairments in ASD, whereas precuneus hypoconnectivity was unrelated to social deficits. Consistent with previous work in healthy adults, a functionally heterogeneous profile of connectivity within the posteromedial cortex in both TD and ASD children was observed. Conclusions: This work links hyperconnectivity of DMN-related circuits to the core social deficits in young children with ASD and highlights fundamental aspects of posteromedial cortex heterogeneity. -
Ideophones in Middle Chinese
KU LEUVEN FACULTY OF ARTS BLIJDE INKOMSTSTRAAT 21 BOX 3301 3000 LEUVEN, BELGIË ! Ideophones in Middle Chinese: A Typological Study of a Tang Dynasty Poetic Corpus Thomas'Van'Hoey' ' Presented(in(fulfilment(of(the(requirements(for(the(degree(of(( Master(of(Arts(in(Linguistics( ( Supervisor:(prof.(dr.(Jean=Christophe(Verstraete((promotor)( ( ( Academic(year(2014=2015 149(431(characters Abstract (English) Ideophones in Middle Chinese: A Typological Study of a Tang Dynasty Poetic Corpus Thomas Van Hoey This M.A. thesis investigates ideophones in Tang dynasty (618-907 AD) Middle Chinese (Sinitic, Sino- Tibetan) from a typological perspective. Ideophones are defined as a set of words that are phonologically and morphologically marked and depict some form of sensory image (Dingemanse 2011b). Middle Chinese has a large body of ideophones, whose domains range from the depiction of sound, movement, visual and other external senses to the depiction of internal senses (cf. Dingemanse 2012a). There is some work on modern variants of Sinitic languages (cf. Mok 2001; Bodomo 2006; de Sousa 2008; de Sousa 2011; Meng 2012; Wu 2014), but so far, there is no encompassing study of ideophones of a stage in the historical development of Sinitic languages. The purpose of this study is to develop a descriptive model for ideophones in Middle Chinese, which is compatible with what we know about them cross-linguistically. The main research question of this study is “what are the phonological, morphological, semantic and syntactic features of ideophones in Middle Chinese?” This question is studied in terms of three parameters, viz. the parameters of form, of meaning and of use. -
Download File
On the Periphery of a Great “Empire”: Secondary Formation of States and Their Material Basis in the Shandong Peninsula during the Late Bronze Age, ca. 1000-500 B.C.E Minna Wu Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Graduate School of Arts and Sciences COLUMIBIA UNIVERSITY 2013 @2013 Minna Wu All rights reserved ABSTRACT On the Periphery of a Great “Empire”: Secondary Formation of States and Their Material Basis in the Shandong Peninsula during the Late Bronze-Age, ca. 1000-500 B.C.E. Minna Wu The Shandong region has been of considerable interest to the study of ancient China due to its location in the eastern periphery of the central culture. For the Western Zhou state, Shandong was the “Far East” and it was a vast region of diverse landscape and complex cultural traditions during the Late Bronze-Age (1000-500 BCE). In this research, the developmental trajectories of three different types of secondary states are examined. The first type is the regional states established by the Zhou court; the second type is the indigenous Non-Zhou states with Dong Yi origins; the third type is the states that may have been formerly Shang polities and accepted Zhou rule after the Zhou conquest of Shang. On the one hand, this dissertation examines the dynamic social and cultural process in the eastern periphery in relation to the expansion and colonization of the Western Zhou state; on the other hand, it emphasizes the agency of the periphery during the formation of secondary states by examining how the polities in the periphery responded to the advances of the Western Zhou state and how local traditions impacted the composition of the local material assemblage which lay the foundation for the future prosperity of the regional culture. -
Thank You to All of Our Reviewers in 2020
EDITORIAL https://doi.org/10.1038/s42003-021-01719-9 OPEN Thank you to all of our reviewers in 2020 5314 individual reviewers contributed to the peer review process at Communications Biology in 2020. We acknowledge and thank each of them here. Communications Biology received more than 3000 research and review article submissions last year, of which over 1700 were sent for external review. In all, 5314 individuals gave their time to ensure a fair and thorough peer review process in the uniquely challenging year that was 2020. These individuals are recognized below in alphabetical order by surname. We are truly grateful to all of our reviewers. Journal staff take full responsibility for any misspellings, omissions, or other errors. Anna M. Åsman Muneeb Ahmed Donát Alpár Luiza Aparecido Adam Abate Warish Ahmed Ahmad Alqudah Samuel Aparicio Cory Abate-Shen Bumsoo Ahn Myriam Altamirano- Sebastien Apcher Juliya Abbasi Velma Aho Bustamante Brian Appleby Geoffrey Abbott Gaurav Ahuja Matthias Altmeyer Rajendra Apte Karen Abbott Nicole Aiello-Couzo Barry Alto Catalina Arévalo Ferro 1234567890():,; Basem Abdallah Ajoy Ajoy Basak Douglas Altshuler Maria Aragona Omar Abdel-Wahab Takashi Akagi Lucia Altucci Mariaceleste Aragona Sarki Abdulkadir Ali Akbari Fernando Alvarez Midori Arai Maha Abdullah Mohsen Akbari Joao Miguel Alves Kazuharu Arakawa Ikuro Abe Fulya Akcimen Nuno Alves Beatrice Aramini Masato Abe Seiji Akimoto Marina Alves Amaral Beatriz Aranda Ethan Abel Aleksei Aksimentiev Kaushalya Amarasinghe Zolt Arany Oscar Abilez David Alabadi Ivano -
Robust Vestibular Self-Motion Signals in Macaque Posterior Cingulate Region Bingyu Liu1,2, Qingyang Tian1,2, Yong Gu1,2*
RESEARCH ARTICLE Robust vestibular self-motion signals in macaque posterior cingulate region Bingyu Liu1,2, Qingyang Tian1,2, Yong Gu1,2* 1CAS Center for Excellence in Brain Science and Intelligence Technology, Key Laboratory of Primate Neurobiology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China; 2University of Chinese Academy of Sciences, Beijing, China Abstract Self-motion signals, distributed ubiquitously across parietal-temporal lobes, propagate to limbic hippocampal system for vector-based navigation via hubs including posterior cingulate cortex (PCC) and retrosplenial cortex (RSC). Although numerous studies have indicated posterior cingulate areas are involved in spatial tasks, it is unclear how their neurons represent self-motion signals. Providing translation and rotation stimuli to macaques on a 6-degree-of-freedom motion platform, we discovered robust vestibular responses in PCC. A combined three-dimensional spatiotemporal model captured data well and revealed multiple temporal components including velocity, acceleration, jerk, and position. Compared to PCC, RSC contained moderate vestibular temporal modulations and lacked significant spatial tuning. Visual self-motion signals were much weaker in both regions compared to the vestibular signals. We conclude that macaque posterior cingulate region carries vestibular-dominant self-motion signals with plentiful temporal components that could be useful for path integration. Introduction Navigation is a fundamental and indispensable ability for creatures -
PDE4D Regulates Spine Plasticity and Memory in the Retrosplenial Cortex
www.nature.com/scientificreports OPEN PDE4D regulates Spine Plasticity and Memory in the Retrosplenial Cortex Received: 17 August 2017 Karsten Baumgärtel1, Andrea Green1, Diana Hornberger1, Jennifer Lapira1, Christopher Rex2, Accepted: 16 February 2018 Damian G. Wheeler1 & Marco Peters1 Published: xx xx xxxx The retrosplenial cortex (RSC) plays a critical role in episodic memory, but the molecular mechanisms governing plasticity in this structure are poorly understood. Diverse studies have demonstrated a role for RSC in acquisition, early consolidation and retrieval similar to the hippocampus (HC), as well as in systems consolidation similar to the anterior cingulate cortex. Here, we asked whether established molecular and structural substrates of memory consolidation in the HC also engage in RSC shortly after learning. We show striking parallels in training induced gene-activation in HC and RSC following contextual conditioning, which is blocked by systemic administration of an NMDA receptor antagonist. Long-term memory is enhanced by retrosplenial and hippocampal knockdown (KD) of the cAMP specifc phosphodiesterase Pde4d. However, while training per se induces lasting spine changes in HC, this does not occur in RSC. Instead, increases in the number of mature dendritic spines are found in the RSC only if cAMP signaling is augmented by Pde4d KD, and spine changes are at least partially independent of training. This research highlights parallels and diferences in spine plasticity mechanisms between HC and RSC, and provides evidence for a functional dissociation of the two. Since the frst description of amnesia in a patient with retrosplenial lesion by Valenstein and colleagues almost 30 years ago1, much of the insight on the role of the retrosplenial cortex (RSC) in memory comes from studies examining its activation, or the efect of its inactivation in animal models2. -
Download Author Version (PDF)
RSC Advances This is an Accepted Manuscript, which has been through the Royal Society of Chemistry peer review process and has been accepted for publication. Accepted Manuscripts are published online shortly after acceptance, before technical editing, formatting and proof reading. Using this free service, authors can make their results available to the community, in citable form, before we publish the edited article. This Accepted Manuscript will be replaced by the edited, formatted and paginated article as soon as this is available. You can find more information about Accepted Manuscripts in the Information for Authors. Please note that technical editing may introduce minor changes to the text and/or graphics, which may alter content. The journal’s standard Terms & Conditions and the Ethical guidelines still apply. In no event shall the Royal Society of Chemistry be held responsible for any errors or omissions in this Accepted Manuscript or any consequences arising from the use of any information it contains. www.rsc.org/advances Page 1 of 7 RSC Advances Journal Name RSC Publishing ARTICLE A new polymer with low dielectric constant based on trifluoromethyl substituted arene: preparation and Cite this: DOI: 10.1039/x0xx00000x properties Jiajia Wang, Kaikai Jin, Fengkai He, Jing Sun and Qiang Fang * Received 00th January 2012, Accepted 00th January 2012 A new polymer with low dielectric constant is reported here. This polymer contains a DOI: 10.1039/x0xx00000x trifluoromethyl substituted phenyl unit and a binaphthyl unit, and shows high thermostability with a glass translation temperature of 244 °C and a 5 wt% loss temperature at 518 °C in www.rsc.org/ nitrogen.