Department of Chemistry R. Graham Cooks Henry Bohn Hass Distinguished Professor

April 26, 2019

SSP Spectroscopy Award Committee 2019 Pittsburgh Spectroscopy Award Chairman c/o Spectroscopy society of Pittsburgh 300 Penn Center Blvd., Suite 332 Pittsburgh, PA 15235-5503

RE: Zheng Ouyang Pitt Spec Award

Dear Selection Committee:

Zheng Ouyang has been a key figure in a series of dramatic advances in what might be called ‘real world’ mass spectrometry. This involves analysis of often complex samples for small molecule drugs, and for compounds of concern for environmental, food safety, and forensic reasons. This ‘blue collar’ area of science has not received the attention accorded to methods that break resolution records or perform other exotic feats. What it does however, is address real societal issues by performing analytical measurements in a cost effective fashion. The examples of this type of measurement range from fentanyls in blood to Sudan dyes in food, from drug metabolites in serum to phospholipid biomarkers in tissue. The solutions that Ouyang has championed combine two elements: ambient ionization for speed and simplicity and portable mass spectrometers for on-site analysis. The ambient ionization method that Ouyang invented is paper spray ionization, commercialized as OmniSpray ® by Prosolia and very recently as PaperSpray ® by Thermo. This method is simple, fast, and quantitative, and particularly well-suited to drugs in biofluids and forensics analyses. The method has been cited some 750 times. There are, according to the Web of Science, 4 highly cited papers on this topic since it was invented in 2010 , and each is authored by Ouyang. Ambient ionization methods are ideally suited to in situ use with portable mass spectrometers. Here too, Zheng Ouyang has made enormous contributions, in leading a Purdue team that developed the Mini 11 and 12 versions of ion trap MS/MS capable instruments. Substantial improvements in ion introduction, vacuum systems, and ion trap operation are included in these compact instruments and a substantial patent portfolio underlies this academic lab effort. Subsequently, Ouyang has established (in both the US and China) a company, PurSpec which is marketing these instruments. Marketing a technology is a necessary aspect of providing a technology to the public and this was Prof. Ouyang’s motivation.

Prof Ouyang has served the national analytical chemistry community through his inventions, publications, role in journals and through the series of symposia at Pittcon on Miniature Mass Spectrometers. These have been held for eight years and a ninth is planned. The symposium in 2018 was selected as the Waters Symposium.

The strength of his scholarship is evident from the 13,000 times his 160 papers have been cited (h index 63). Perhaps even more notable is the commercialization of his paper spray technology by Prosolia and recently Waters, his 55 US patents and his role as CEO and founder of PurSpec Technologies, a mini mass spectrometry company. Dr Ouyang’s work has been

560 Oval Drive ▲ West Lafayette, IN 47907-2084 ▲ (765) 494-5263 ▲ (765) 494-9421 ▲ [email protected] funded by NASA (the ExoMars mission is using his discontinuous atmospheric pressure interface), by several NIH R01 grants, and by NSF (Early Career Award).

Zheng Ouyang is certainly the most inventive person I have ever worked with. He is brilliant, highly creative, and a good colleague. I believe him to be extremely highly deserving of this honor, which will bring appropriate credit to him and encourage the international exchange of information, which underlies all of science.

Sincerely,

R. Graham Cooks

DEPARTMENT OF CHEMISTRY, 560 Oval Drive WEST LAFAYETTE, IN 47907-2084 • (765) 494-5263 • FAX: (765) 494-9421 • E-MAIL: [email protected] Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 1 of 23

ZHENG OUYANG Professor Department of Precision Instrument, Tsinghua University, Beijing 100084, China Email: [email protected]

Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA Email: [email protected]

EDUCATION&TRAINING  B.E. Automatic Control, Tsinghua University, Beijing, China, July 1993.  M.E. Automatic Control Theory and Its Application, Tsinghua University, Beijing, China, July 1995.  M.S. Physical Chemistry, West Virginia University, Morgantown, WV, May 1997.  Ph. D. Analytical Chemistry, Purdue University, West Lafayette, IN, May 2002  Postdoc Analytical Chemistry, Purdue University, West Lafayette, IN, February 2002 - February 24, 2003

POSITIONS 2003 – 2005 Assistant Research Scientist, Department of Chemistry, Purdue University 2006 – 2007 Associate Research Scientist, Department of Chemistry, Purdue University 2006 – 2008 Guest Professor, Institute of Metrology of China 2007 – 2012 Assistant Professor, Weldon School of Biomedical Engineering, Purdue University 2012 – 2015 Associate Professor, Weldon School of Biomedical Engineering, Purdue University 2008 – 2016 Assistant/Associate/Full Professor (courtesy), Department of Electrical and Computer Engineering, Purdue University 2014 – 2016 Associate/Full Professor (courtesy), Department of Chemistry, Purdue University 2015 – 2016 Professor, Weldon School of Biomedical Engineering, Purdue University 2015 – 2016 Professor (courtesy), Department of Precision Instrument, Tsinghua University 2016 – present Professor (adjunct), Weldon School of Biomedical Engineering, Purdue University 2017 – present Professor, Department of Precision Instrument, Tsinghua University 2017 – present Chairman, Department of Precision Instrument, Tsinghua University 2017 – present Deputy Dean, School of Mechanical Engineering, Tsinghua University

PROFESSIONAL AFFILIATION  American Chemical Society  American Society for Mass Spectrometry  American Institute for Medical and Biological Engineering (Fellow)

ENTREPRENEURIAL ACTIVITIES  Founder of PURSPEC Technologies, Inc.  Founding Director of Shanghai Institute for Analytical Technology

AWARDS AND HONORS 1999-2002 Phillips Petroleum Fellowship, 1999-2002 2007 China National Natural Science Foundation Award for Distinguished Oversea Young Scholars 2008 Wallace H. Coulter Foundation Early Career Translational Research Award in Biomedical Engineering 2009 National Science Foundation Early Career Award 2009 American Society for Mass Spectrometry Research Award 2010 China National Science and Technology Advancement Award (2nd Class) 2012 International Mass Spectrometry Foundation, Curt Brunnée Award for outstanding contributions to the development of instrumentation for mass spectrometry 2013 Purdue University College of Engineering Early Career Research Award 2014 Purdue University Faculty Scholar 2016 Fellow of American Institute for Medical and Biological Engineering

EDITORIAL BOARD Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 2 of 23

 Co-Editor, International Journal of Mass Spectrometry, 2016 – present  Associate Editor, Encyclopedia of Analytical Chemistry, 2016 - present  Editorial Board, Journal of The American Society for Mass Spectrometry, 2015 – present  Guest Editor, Analyst, Themed Issue “Ambient Mass Spectrometry”, 2010  Guest Editor, Analytical Method, Themed Issue “Portable Instrumentation & Point Of Care Technologies”, 2016

CONFERENCE ORGNIZING/WORKSHOP PARTICIPATION  Co-chair, “Miniature Mass Spectrometers” session, Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, 2011-1019  Lecturer, American Society for Mass Spectrometry, 2006 Fall Workshop “The Present & Future of Quadrupole Ion Trap Mass Spectrometry” – “Miniature Mass Spectrometry” , San Diego, CA, November 9-10, 2006.  Organizer and co-chair, Midwestern Universities Analytical Chemistry Conference, 2010  Co-organizer, 1st US-China Analytical Chemistry Workshop, West Lafayette, IN, USA, 2011  Co-organizer, 2nd US-China Analytical Chemistry Workshop, Beijing, China, 2012  Lecturer, International Mass Spectrometry Conference 2014, Short Course, “Ambient Ionization”, Geneva, Switzerland, August 24-29, 2014  Co-chair, American Society for Mass Spectrometry Asilomar Conference on Mass Spectrometry, 2016  Vice chair, Gordon Research Conference “Molecular Structure Elucidation”, 2016  Co-Chair, Gordon Research Conference “Molecular Structure Elucidation”, 2018

PATENTS 1. Cooks, R. G.; Badman, E. R.; Ouyang, Z.; Wells, J. M. Ion trap array mass spectrometer. US 6762406, 2004. 2. Ouyang, Z.; Cooks, R. G. Rectilinear ion trap and mass analyzer system and method. US 6838666, 2005. 3. Gologan, B.; Takats, Z.; Ouyang, Z.; Cooks, R. System and method for landing of ions on a gas/liquid interface. US 11228946, 2006. 4. Ouyang, Z.; Cooks, R. G. Multiplexed mass spectrometer. US 7157699, 2007. 5. Blake, T.; Ouyang, Z.; Cooks, R. G. System and method for preparative mass spectrometry. US 7381373, 2008. 6. Cooks, R. G.; Ouyang, Z. System and method for the preparation of arrays of biological or other molecules. US 7361311, 2008. 7. Cooks, R. G.; Ouyang, Z.; Song, Y.; Wu, G. Linear Ion Trap with Four Planar Electrodes. US 11814334, 2009. 8. Cooks, R. G.; Peng, W.-P.; Ouyang, Z.; Goodwin, M. P. Methods and apparatuses for preparing a surface to have catalytic activity. US 7910377, 2011. 9. Ouyang, Z.; Gao, L.; Cooks, R. G. Discontinuous atmospheric pressure interface. US 8304718, 2012. 10. Charipar, N.; Harper, J.; Ouyang, Z.; Cooks, R. G. Low temperature plasma probe and methods of use thereof. US 8519354, 2013. 11. Ouyang, Z.; Cooks, R. G.; Garimella, S. V.; Harper, J. D.; Charipar, N. A. Systems and methods for transfer of ions for analysis. US 8410431, 2013. 12. Xu, W.; Chappell, W.; Ouyang, Z.; Cooks, R. G. Non-destructive, high order harmonic ion motion image current detection. US 8362418, 2013. 13. Charipar, N.; Harper, J.; Ouyang, Z.; Cooks, R. G. Low temperature plasma probe and methods of use thereof. US 8772710, 2014. 14. Cooks, R. G.; Badman, E. R.; Ouyang, Z.; Wells, J. M. Ion trap array mass spectrometer. US 6762406, 2014. 15. Cooks, R. G.; Hamid, A. M.; Jarmusch, A. K.; Ouyang, Z. Mass spectrometry analysis of microorganisms in samples. US 8704167, 2014. 16. Cooks, R. G.; Hamid, A. M.; Jarmusch, A. K.; Ouyang, Z. Ion generation using wetted porous material. US 8859956, 2014. 17. Cooks, R. G.; Ouyang, Z.; Zhang, Z. Ion generation using modified wetted porous materials. US 8895918, 2014. 18. Cooks, R. G.; Ouyang, Z.; Zhang, Z. Ion generation using wetted porous material. US 8890063, 2014. 19. Ouyang, Z.; Cooks, R. G.; Garimella, S. V.; Harper, J. D.; Charipar, N. A. Systems and methods for transfer of ions for analysis. US 8686351, 2014. 20. Ouyang, Z.; Cooks, R. G.; Hou, K. Systems and methods for sample analysis. US 9165752, 2014. 21. Ouyang, Z.; Gao, L.; Cooks, R. G. Discontinuous atmospheric pressure interface. US 8766178, 2014. 22. Ouyang, Z.; Tsung-Chi, C. Systems and methods for analyzing a sample. US 8785846, 2014. 23. Ouyang, Z.; Wang, H.; Manicke, N. E.; Cooks, R. G.; Yang, Q.; Liu, J. Ion generation using wetted porous Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 3 of 23

material. US 8816275, 2014. 24. Cooks, R. G.; Hamid, A. M.; Jarmusch, A. K.; Ouyang, Z. Mass spectrometry analysis of microorganisms in samples. US 8937288, 2015. 25. Cooks, R. G.; Li, G.; Li, X.; Ouyang, Z. Systems and methods for sample analysis. US 8932875, 2015. 26. Cooks, R. G.; Ouyang, Z.; Chen, C.-H.; Lin, Z.; Schiavinato, L. Enclosed desorption electrospray ionization probes and method of use thereof. US 9024254, 2015. 27. Ouyang, Z.; Cooks, R. G.; Garimella, S. V.; Harper, J. D.; Charipar, N. A. Systems and methods for transfer of ions for analysis. US 9159540, 2015. 28. Ouyang, Z.; Gao, L.; Cooks, R. G. Discontinuous atmospheric pressure interface. US 9058967, 2015. 29. Ouyang, Z.; Ren, Y.; Liu, J.; Li, L. Systems and methods for analyzing an extracted sample. US 14426591, 2015. 30. Ouyang, Z.; Tsung-Chi, C. Systems and methods for analyzing a sample. US 9129786, 2015. 31. Ouyang, Z.; Wang, H.; Manicke, N. E.; Cooks, R. G.; Yang, Q.; Liu, J. Ion generation using wetted porous material. US 8933398, 2015. 32. Cooks, R. G.; Ouyang, Z. Rare event detection using mass tags. US 14862517, 2016. 33. Cooks, R. G.; Ouyang, Z.; Wang, H. Ion generation using modified wetted porous materials. US 9500630, 2016. 34. Cooks, R. G.; Ouyang, Z.; Zhang, Z. Ion generation using modified wetted porous materials. US 9230792, 2016. 35. Ouyang, Z.; Cooks, R. G.; Garimella, S. V.; Harper, J. D.; Charipar, N. A. Systems and methods for transfer of ions for analysis. US 9484195, 2016. 36. Ouyang, Z.; Li, L.; Zhou, X. Sample quantitation with a miniature mass spectrometer. US 14909269, 2016. 37. Ouyang, Z.; Liu, J.; Ren, Y.; McLuckey, M. Systems and methods for analyzing an extracted sample using an immiscible extraction solvent. US 15113945, 2016. 38. Ouyang, Z.; Ren, Y.; Lin, Z. Systems and methods for quantifying an analyte extracted from a sample. US 15064865, 2016. 39. Ouyang, Z.; Wang, H.; Manicke, N. E.; Cooks, R. G.; Yang, Q.; Liu, J. Sample dispenser including an internal standard and methods of use thereof. US 9500572, 2016. 40. Cooks, R. G.; Hamid, A. M.; Jarmusch, A. K.; Ouyang, Z. Mass spectrometry analysis of microorganisms in samples. US 14900827, 2017. 41. Cooks, R. G.; Ouyang, Z.; Chen, C.-H.; Lin, Z.; Eberlin, L. S. Enclosed desorption electrospray ionization probes and method of use thereof. US 15617013, 2017. 42. Cooks, R. G.; Ouyang, Z.; Chen, C.-H.; Lin, Z.; Eberlin, L. S. Desorption electrospray ionization sampling without damaging an in vivo tissue sample. US 09538945, 2017. 43. Cooks, R. G.; Ouyang, Z.; Espy, R. Ion generation using modified wetted porous materials. US 15359031, 2017. 44. Ouyang, Z.; Cooks, R. G.; Garimella, S. V.; Harper, J. D.; Charipar, N. A. Systems and methods for transfer of ions for analysis. US 15340355, 2017. 45. Ouyang, Z.; Wang, H.; Manicke, N. E.; Cooks, R. G.; Yang, Q.; Liu, J. Sample dispenser including an internal standard and methods of use thereof. US 15357048, 2017. 46. Cooks, R. G.; Hamid, A. M.; Jarmusch, A. K.; Ouyang, Z. Mass spectrometry analysis of microorganisms in samples. US 15902068, 2018. 47. Cooks, R. G.; Ouyang, Z. Ion generation using modified wetted porous materials. US 15710072, 2018. 48. Cooks, R. G.; Ouyang, Z. Ion generation using modified wetted porous materials. US 16107296, 2018. 49. Cooks, R. G.; Ouyang, Z.; Chen, C.-H.; Lin, Z.; Eberlin, L. S. Enclosed desorption electrospray ionization probes and method of use thereof. US 15989706, 2018. 50. Ouyang, Z.; Cooks, R. G.; Garimella, S. V.; Harper, J. D.; Charipar, N. A. Systems and methods for transfer of ions for analysis. US 10008374, 2018. 51. Ouyang, Z.; Ren, Y.; Wang, X. Probes, systems, cartridges, and methods of use thereof. US 15548275, 2018. 52. Ouyang, Z.; Wang, X.; Zhou, X. Systems and methods for analyzing a sample from a surface. US 15318846, 2018. 53. Ouyang, Z.; Xia, Y.; Ma, X. Methods for analyzing a tissue sample. US 15577516, 2018. 54. Zane, B.; Cooks, R. G.; Hollerbach, A.; Ouyang, Z.; Pugia, M. Mass tag analysis for rare cells and cell free molecules. US 15762597, 2018. 55. Cooks, R. G.; Ouyang, Z.; Chen, C.-H.; Lin, Z.; Eberlin, L. S. Enclosed desorption electrospray ionization probes and method of use thereof. US 10212143, 2019.

BOOK CHAPTERS and COLUMN ARTICLES Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 4 of 23

1. Z. Ouyang, P. Yang and R. G. Cooks, "Electrospray Ionization with Venturi and Related Devices" in The Encyclopedia of Mass Sepctrometry, Volumn 6: Ionization Methods, eds. M. L. Gross and R. M. Caprioli, Elsevier Science, Oxford, UK, Editon edn., 2006, vol. 6, pp. 498-502. 2. S. A. Smith, C. C. Mulligan, Q. Song, R. J. Noll, R. G. Cooks and Z. Ouyang, "Ion Traps for Miniature, Multiplexed and Soft Landing Technologies" in Practical Aspects of Ion Trap Mass Spectrometry, Volume 4: Theory and Instrumentation, eds. R. E. March and J. F. J. Todd, CRC Press, Boca Raton, FL, Editon edn., 2010, vol. 5. 3. S. A. Smith, R. W. Smith, Y. Xia and Z. Ouyang, "Introduction to Mass Spectrometry" in Characterization of impurities and degradants using mass spectrometry, eds. B. N. Pramanik, M. S. Lee and G. Chen, John Wiley & Sons, Editon edn., 2010, pp. 3-57. 4. R. J. N. Gautam Sharma, Zheng Ouyang, Rober Graham Cooks, "Miniaturised Mass Spectrometers for Environmental Analysis" in Comprehensive Environmental Mass Spectrometry, ed. A. T. Lebedev, ILM Publications, Editon edn., 2012, pp. 185-224. 5. J. Liu, X. Chuang and Z. Ouyang, "Data Processing and Analysis for Mass Spectrometry Imaging" in Mass Spectrometry Imaging of Small Molecules, ed. L. He, Springer Sciece+Business Media, LLC, New York, NY, USA, Editon edn., 2014. 6. J. Liu, R. G. Cooks and Z. Ouyang, "Low Temperature Plasma Probe" in Ambient Ionization Mass Spectrometry, eds. M. A. Domin and R. B. Cody, Royal Society of Chemistry, Cambridge, UK, Editon edn., 2014. 7. J. Liu, N. E. Manicke, R. G. Cooks and Z. Ouyang, "Paper Spray Ionization for Direct Analysis of Dried Blood Spots" in Dried Blood Spots: Analytical Techniques and Applications, eds. M. S. Lee and W. LI, John Wiley & Sons, Inc., Hoboken, NJ, US, Editon edn., 2014. 8. J. Liu, N. E. Manicke, R. G. Cooks and Z. Ouyang, "Paper Spray" in Ambient Ionization Mass Spectrometry, eds. M. A. Domin and R. B. Cody, Royal Society of Chemistry, Cambridge, UK, Editon edn., 2014. 9. J. S. Wiley, Z. Takats, Z. Ouyang and R. G. Cooks, "Desorption Electrospray Ionization" in Ambient Ionization Mass Spectrometry, eds. M. A. Domin and R. B. Cody, Royal Society of Chemistry, Cambridge, UK, Editon edn., 2014. 10. Z. Ouyang, "Future of Miniature Mass Spectrometry Analysis Systems and Path Forward: Fragmented Thoughts from An Academic Researcher", LCGC North America, 2014, 32, 104-112. JOURNAL PUBLICATIONS (peer reviewed) 1. Wang, W.; Ouyang, Z., DEC Net-DOS network file Access and task to task communication. Microprocessor and Application 1994, Feb. 2. Kao, E. C.; Ouyang, Z.; Sneckenberger, S.; Xie, D.; Jagodzinski, P. W.; Culbertson, B. M., Setting reactions of amino-modified glass ionomer restoratives. Journal of Dental Research 1998, 77, 169-169. 3. Ouyang, Z.; Badman, E. R.; Cooks, R. G., Characterization of a serial array of miniature cylindrical ion trap mass analyzers. Rapid Commun Mass Spectrom 1999, 13 (24), 2444-9. 4. Ouyang, Z.; Sneckenberger, S. K.; Kao, E. C.; Culbertson, B. M.; Jagodzinski, P. W., New method for monitoring the reaction of glass-ionomer cements: A spectroscopic study of the effects of polyacid structure on the decomposition of calcium aluminosilicate glasses. Applied Spectroscopy 1999, 53 (3), 297-301. 5. Wells, J. M.; Plass, W. R.; Patterson, G. E.; Ouyang, Z.; Badman, E. R.; Cooks, R. G., Chemical mass shifts in ion trap mass spectrometry: Experiments and simulations. Analytical Chemistry 1999, 71 (16), 3405-3415. 6. Ouyang, Z.; Grill, V.; Alvarez, J.; Doerge, C. H.; Gianelli, L.; Thomas, P.; Rohrs, H. W.; Cooks, R. G., A multiquadrupole tandem mass spectrometer for the study of ion/surface collision processes. Review of Scientific Instruments 2002, 73 (6), 2375-2391. 7. Patterson, G. E.; Guymon, A. J.; Riter, L. S.; Everly, M.; Griep-Raming, J.; Laughlin, B. C.; Ouyang, Z.; Cooks, R. G., Miniature cylindrical ion trap mass spectrometer. Analytical Chemistry 2002, 74 (24), 6145-53. 8. Ouyang, Z.; Takats, Z.; Blake, T. A.; Gologan, B.; Guymon, A. J.; Wiseman, J. M.; Oliver, J. C.; Davisson, V. J.; Cooks, R. G., Preparing protein microarrays by soft-landing of mass-selected ions. Science 2003, 301 (5638), 1351-1354. 9. Blake, T. A.; Ouyang, Z.; Wiseman, J. M.; Takats, Z.; Guymon, A. J.; Kothari, S.; Cooks, R. G., Preparative linear ion trap mass spectrometer for separation and collection of purified proteins and peptides in arrays using ion soft landing. Analytical Chemistry 2004, 76 (21), 6293-305. 10. Gologan, B.; Takats, Z.; Alvarez, J.; Wiseman, J. M.; Talaty, N.; Ouyang, Z.; Cooks, R. G., Ion soft-landing into liquids: Protein identification, separation, and purification with retention of biological activity. Journal of the American Society for Mass Spectrometry 2004, 15 (12), 1874-1884. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 5 of 23

11. Ouyang, Z.; Wu, G. X.; Song, Y. S.; Li, H. Y.; Plass, W. R.; Cooks, R. G., Rectilinear ion trap: Concepts, calculations, and analytical performance of a new mass analyzer. Analytical Chemistry 2004, 76 (16), 4595-4605. 12. Chen, H. W.; Xu, R. F.; Chen, H.; Cooks, R. G.; Ouyang, Z., Ion/molecule reactions in a miniature RIT mass spectrometer. Journal of Mass Spectrometry 2005, 40 (11), 1403-1411. 13. Misharin, A. S.; Laughlin, B. C.; Vilkov, A.; Takats, Z.; Ouyang, Z.; Cooks, R. G., High-throughput mass spectrometer using atmospheric pressure ionization and a cylindrical ion trap array. Anal Chem 2005, 77 (2), 459-70. 14. Wu, G. X.; Cooks, R. G.; Ouyang, Z., Geometry optimization for the cylindrical ion trap: field calculations, simulations and experiments. International Journal of Mass Spectrometry 2005, 241 (2-3), 119-132. 15. Yang, P. X.; Cooks, R. G.; Ouyang, Z.; Hawkridge, A. M.; Muddiman, D. C., Gentle protein ionization assisted by high-velocity gas flow. Analytical Chemistry 2005, 77 (19), 6174-6183. 16. Chen, H.; Ouyang, Z.; Cooks, R. G., Thermal production and reactions of organic ions at atmospheric pressure. Angewandte Chemie International Edition 2006, 45 (22), 3656-60. 17. Cooks, R. G.; Ouyang, Z.; Takats, Z.; Wiseman, J. M., Ambient mass spectrometry. Science 2006, 311 (5767), 1566-1570. 18. Gao, L.; Song, Q. Y.; Patterson, G. E.; Cooks, R. G.; Ouyang, Z., Handheld rectilinear ion trap mass spectrometer. Analytical Chemistry 2006, 78 (17), 5994-6002. 19. Song, Q. Y.; Kothari, S.; Senko, M. A.; Schwartz, J. C.; Amy, J. W.; Stafford, G. C.; Cooks, R. G.; Ouyang, Z., Rectilinear ion trap mass spectrometer with atmospheric pressure interface and electrospray ionization source. Analytical Chemistry 2006, 78 (3), 718-725. 20. Song, Y. S.; Wu, G. X.; Song, Q. Y.; Cooks, R. G.; Ouyang, Z.; Plass, W. R., Novel linear ion trap mass analyzer composed of four planar electrodes. Journal of the American Society for Mass Spectrometry 2006, 17 (4), 631-639. 21. Wu, G. X.; Cooks, R. G.; Ouyang, Z.; Yu, M.; Chappell, W. J.; Plass, W. R., Ion trajectory simulation for electrode configurations with arbitrary geometries. Journal of the American Society for Mass Spectrometry 2006, 17 (9), 1216-1228. 22. Yu, M.; Fico, M.; Kothari, S.; Ouyang, Z.; Chappell, W. J., Polymer-based ion trap chemical sensor. Ieee Sensors Journal 2006, 6 (6), 1429-1434. 23. Zhang, C.; Chen, H. W.; Guymon, A. J.; Wu, G. X.; Cooks, R. G.; Ouyang, Z., Instrumentation and methods for ion and reaction monitoring using a non-scanning rectilinear ion trap. International Journal of Mass Spectrometry 2006, 255, 1-10. 24. Fedulova, I.; Ouyang, Z.; Buck, C.; Zhang, X., PepTiger: Search Engine for Error-Tolerant Protein Identification from de Novo Sequences. The Open Spectroscopy Journal 2007, 1, 1-8. 25. Fico, M.; Yu, M.; Ouyang, Z.; Cooks, R. G.; Chappell, W. J., Miniaturization and geometry optimization of a polymer-based rectilinear ion trap. Analytical Chemistry 2007, 79 (21), 8076-8082. 26. Gao, L.; Song, Q.; Noll, R. J.; Duncan, J.; Cooks, R. G.; Ouyang, Z., Glow discharge electron impact ionization source for miniature mass spectrometers. J Mass Spectrom 2007, 42 (5), 675-80. 27. Huang, G.; Chen, H.; Zhang, X.; Cooks, R. G.; Ouyang, Z., Rapid screening of anabolic steroids in urine by reactive Desorption Electrospray ionization. Analytical Chemistry 2007, 79 (21), 8327-8332. 28. Keil, A.; Talaty, N.; Janfelt, C.; Noll, R. J.; Gao, L.; Ouyang, Z.; Cooks, R. G., Ambient mass spectrometry with a handheld mass spectrometer at high pressure. Analytical Chemistry 2007, 79 (20), 7734-7739. 29. Ouyang, Z.; Gao, L.; Fico, M.; Chappell, W. J.; Noll, R. J.; Cooks, R. G., Quadrupole ion traps and trap arrays: geometry, material, scale, performance. European Journal of Mass Spectrometry 2007, 13 (1), 13-18. 30. Smith, S. A.; Blake, T. A.; Ifa, D. R.; Cooks, R. G.; Ouyang, Z., Dual-source mass spectrometer with MALDI- LIT-ESI configuration. J Proteome Res 2007, 6 (2), 837-45. 31. Gao, L.; Cooks, R. G.; Ouyang, Z., Breaking the pumping speed barrier in mass spectrometry: Discontinuous atmospheric pressure interface. Analytical Chemistry 2008, 80 (11), 4026-4032. 32. Gao, L.; Sugiarto, A.; Harper, J. D.; Cooks, R. G.; Ouyang, Z., Design and characterization of a multisource hand-held tandem mass spectrometer. Analytical Chemistry 2008, 80 (19), 7198-7205. 33. Harper, J. D.; Charipar, N. A.; Mulligan, C. C.; Zhang, X. R.; Cooks, R. G.; Ouyang, Z., Low-Temperature Plasma Probe for Ambient Desorption Ionization. Analytical Chemistry 2008, 80 (23), 9097-9104. 34. Janfelt, C.; Talaty, N.; Mulligan, C. C.; Keil, A.; Ouyang, Z.; Cooks, R. G., Mass spectra of proteins and other biomolecules recorded using a handheld instrument. International Journal of Mass Spectrometry 2008, 278 (2- 3), 166-169. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 6 of 23

35. Keil, A.; Hernandez-Soto, H.; Noll, R. J.; Fico, M.; Gao, L.; Ouyang, Z.; Cooks, R. G., Monitoring of toxic compounds in air using a handheld rectilinear ion trap mass spectrometer. Analytical Chemistry 2008, 80 (3), 734-741. 36. Peng, W.-P.; Goodwin, M. P.; Nie, Z.; Volny, M.; Ouyang, Z.; Cooks, R. G., Ion Soft Landing Using a Rectilinear Ion Trap Mass Spectrometer. Analytical Chemistry 2008, 80 (17), 6640-6649. 37. Xia, Y.; Ouyang, Z.; Cooks, R. G., Peptide Fragmentation Assisted by Surfaces Treated with a Low-Temperature Plasma in NanoESI. Angewandte Chemie-International Edition 2008, 47 (45), 8646-8649. 38. Dill, A. L.; Ifa, D. R.; Manicke, N. E.; Ouyang, Z.; Cooks, R. G., Mass spectrometric imaging of lipids using desorption electrospray ionization. Journal of Chromatography B 2009, 877 (26), 2883-2889. 39. Fico, M.; Maas, J. D.; Smith, S. A.; Costa, A. B.; Ouyang, Z.; Chappell, W. J.; Cooks, R. G., Circular arrays of polymer-based miniature rectilinear ion traps. Analyst 2009, 134 (7), 1338-1347. 40. Gao, L.; Li, G.; Nie, Z.; Duncan, J.; Ouyang, Z.; Cooks, R. G., Characterization of a discontinuous atmospheric pressure interface. Multiple ion introduction pulses for improved performance. International Journal of Mass Spectrometry 2009, 283 (1-3), 30-34. 41. Garcia-Reyes, J. F.; Mazzoti, F.; Harper, J. D.; Charipar, N. A.; Oradu, S.; Ouyang, Z.; Sindona, G.; Cooks, R. G., Direct olive oil analysis by low-temperature plasma (LTP) ambient ionization mass spectrometry. Rapid Communications in Mass Spectrometry 2009, 23 (19), 3057-3062. 42. Huang, G. M.; Ouyang, Z.; Cooks, R. G., High-throughput trace melamine analysis in complex mixtures. Chemical Communications 2009, (5), 556-558. 43. Manicke, N. E.; Kistler, T.; Ifa, D. R.; Cooks, R. G.; Ouyang, Z., High-Throughput Quantitative Analysis by Desorption Electrospray Ionization Mass Spectrometry. Journal of the American Society for Mass Spectrometry 2009, 20 (2), 321-325. 44. Ouyang, Z.; Cooks, R. G., Miniature Mass Spectrometers. Annual Review of Analytical Chemistry 2009, 2 (1), 187-214. 45. Ouyang, Z.; Noll, R. J.; Cooks, R. G., Handheld Miniature Ion Trap Mass Spectrometers. Analytical Chemistry 2009, 81 (7), 2421–2425. 46. Song, Q.; Smith, S. A.; Gao, L.; Xu, W.; Volny, M.; Ouyang, Z.; Cooks, R. G., Mass Selection of Ions from Beams Using Waveform Isolation in Radiofrequency Quadrupoles. Analytical Chemistry 2009, 81 (5), 1833- 1840. 47. Xu, W.; Chappell, W. J.; Cooks, R. G.; Ouyang, Z., Characterization of electrode surface roughness and its impact on ion trap mass analysis. Journal of Mass Spectrometry 2009, 44 (3), 353-360. 48. Xu, W.; Song, Q. Y.; Smith, S. A.; Chappell, W. J.; Ouyang, Z., Ion Trap Mass Analysis at High Pressure: A Theoretical View. Journal of the American Society for Mass Spectrometry 2009, 20 (11), 2144-2153. 49. Zhang, Y.; Ma, X. X.; Zhang, S. C.; Yang, C. D.; Ouyang, Z.; Zhang, X. R., Direct detection of explosives on solid surfaces by low temperature plasma desorption mass spectrometry. Analyst 2009, 134 (1), 176-181. 50. Cooks, R. G.; Ifa, D. R.; Sharma, G.; Tadjimukhamedov, F. K.; Ouyang, Z., Perspectives and retrospectives in mass spectrometry: one view. European Journal of Mass Spectrometry 2010, 16 (3), 283-300. 51. Huang, G.; Gao, L.; Duncan, J.; Harper, J. D.; Sanders, N. L.; Ouyang, Z.; Cooks, R. G., Direct Detection of Benzene, Toluene, and Ethylbenzene at Trace Levels in Ambient Air by Atmospheric Pressure Chemical Ionization Using a Handheld Mass Spectrometer. Journal of the American Society for Mass Spectrometry 2010, 21 (1), 132-135. 52. Huang, G.; Xu, W.; Visbal-Onufrak, M. A.; Ouyang, Z.; Cooks, R. G., Direct analysis of melamine in complex matrices using a handheld mass spectrometer. Analyst 2010, 135 (4), 705-711. 53. Ifa, D. R.; Wu, C. P.; Ouyang, Z.; Cooks, R. G., Desorption electrospray ionization and other ambient ionization methods: current progress and preview. Analyst 2010, 135 (4), 669-681. 54. Jackson, A. U.; Garcia-Reyes, J. F.; Harper, J. D.; Wiley, J. S.; Molina-Diaz, A.; Ouyang, Z.; Cooks, R. G., Analysis of drugs of abuse in biofluids by low temperature plasma (LTP) ionization mass spectrometry. Analyst 2010, 135 (5), 927-933. 55. Liu, J. J.; Wang, H.; Manicke, N. E.; Lin, J. M.; Cooks, R. G.; Ouyang, Z., Development, Characterization, and Application of Paper Spray Ionization. Analytical Chemistry 2010, 82 (6), 2463-2471. 56. Maas, J. D.; Hendricks, P. I.; Zheng, O.; Cooks, R. G.; Chappell, W. J., Miniature Monolithic Rectilinear Ion Trap Arrays by Stereolithography on Printed Circuit Board. Microelectromechanical Systems, Journal of 2010, 19 (4), 951-960. 57. Ouyang, Z.; Zhang, X. R., Ambient mass spectrometry. Analyst 2010, 135 (4), 659-660. 58. Song, Q.; Xu, W.; Smith, S. A.; Gao, L.; Chappell, W. J.; Cooks, R. G.; Ouyang, Z., Ion trap mass analysis at high pressure: an experimental characterization. Journal of Mass Spectrometry 2010, 45 (1), 26-34. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 7 of 23

59. Tadjimukhamedov, F. K.; Jackson, A. U.; Nazarov, E. G.; Ouyang, Z.; Cooks, R. G., Evaluation of a Differential Mobility Spectrometer/Miniature Mass Spectrometer System. Journal of the American Society for Mass Spectrometry 2010, 21 (9), 1477-1481. 60. Wang, H.; Liu, J. J.; Cooks, R. G.; Ouyang, Z., Paper Spray for Direct Analysis of Complex Mixtures Using Mass Spectrometry. Angewandte Chemie-International Edition 2010, 49 (5), 877-880. 61. Wang, H.; Ouyang, Z.; Xia, Y., Peptide Fragmentation during Nanoelectrospray Ionization. Analytical Chemistry 2010, 82 (15), 6534-6541. 62. Wiley, J. S.; Garcia-Reyes, J. F.; Harper, J. D.; Charipar, N. A.; Ouyang, Z.; Cooks, R. G., Screening of agrochemicals in foodstuffs using low-temperature plasma (LTP) ambient ionization mass spectrometry. Analyst 2010, 135 (5), 971-979. 63. Xu, W.; Charipar, N.; Kirleis, M. A.; Xia, Y.; Ouyang, Z., Study of Discontinuous Atmospheric Pressure Interfaces for Mass Spectrometry Instrumentation Development. Analytical Chemistry 2010, 82 (15), 6584-6592. 64. Xu, W.; Manicke, N. E.; Cooks, G. R.; Ouyang, Z., Miniaturization of Mass Spectrometry Analysis Systems. Jala 2010, 15 (6), 433-439. 65. Chen, T. C.; Xu, W.; Ouyang, Z., Dual buffer gases for ion manipulation in a miniature ion trap mass spectrometer with a discontinuous atmospheric pressure interface. Rapid Communications in Mass Spectrometry 2011, 25 (21), 3274-3280. 66. Cooks, R. G.; Manicke, N. E.; Dill, A. L.; Ifa, D. R.; Eberlin, L. S.; Costa, A. B.; Wang, H.; Huang, G. M.; Ouyang, Z., New ionization methods and miniature mass spectrometers for biomedicine: DESI imaging for cancer diagnostics and paper spray ionization for therapeutic drug monitoring. Faraday Discussions 2011, 149, 247-267. 67. Garcia-Reyes, J. F.; Harper, J. D.; Salazar, G. A.; Charipar, N. A.; Ouyang, Z.; Cooks, R. G., Detection of Explosives and Related Compounds by Low-Temperature Plasma Ambient Ionization Mass Spectrometry. Analytical Chemistry 2011, 83 (3), 1084-1092. 68. Hendricks, P.; Duncan, J.; Noll, R. J.; Ouyang, Z.; Cooks, R. G., Performance of a low voltage ion trap. International Journal of Mass Spectrometry 2011, 305 (1), 69-73. 69. Hou, K. Y.; Xu, W.; Xu, J. A.; Cooks, R. G.; Ouyang, Z., Sampling Wand for an Ion Trap Mass Spectrometer. Analytical Chemistry 2011, 83 (5), 1857-1861. 70. Huang, G. M.; Li, G. T.; Ducan, J.; Ouyang, Z.; Cooks, R. G., Synchronized Inductive Desorption Electrospray Ionization Mass Spectrometry. Angewandte Chemie-International Edition 2011, 50 (11), 2503-2506. 71. Li, A. Y.; Wang, H.; Ouyang, Z.; Cooks, R. G., Paper spray ionization of polar analytes using non-polar solvents. Chemical Communications 2011, 47 (10), 2811-2813. 72. Liu, J.; Wang, H.; Cooks, R. G.; Ouyang, Z., Leaf Spray: Direct Chemical Analysis of Plant Material and Living Plants by Mass Spectrometry. Analytical Chemistry 2011, 83 (20), 7608–7613. 73. Liu, J. J.; Cooks, R. G.; Ouyang, Z., Biological Tissue Diagnostics Using Needle Biopsy and Spray Ionization Mass Spectrometry. Analytical Chemistry 2011, 83 (24), 9221-9225. 74. Manicke, N. E.; Abu-Rabie, P.; Spooner, N.; Ouyang, Z.; Cooks, R. G., Quantitative Analysis of Therapeutic Drugs in Dried Blood Spot Samples by Paper Spray Mass Spectrometry: An Avenue to Therapeutic Drug Monitoring. Journal of the American Society for Mass Spectrometry 2011, 22 (9), 1501-1507. 75. Manicke, N. E.; Yang, Q. A.; Wang, H.; Oradu, S.; Ouyang, Z.; Cooks, R. G., Assessment of paper spray ionization for quantitation of pharmaceuticals in blood spots. International Journal of Mass Spectrometry 2011, 300 (2-3), 123-129. 76. Prentice, B. M.; Xu, W.; Ouyang, Z.; McLuckey, S. A., DC potentials applied to an end-cap electrode of a 3D ion trap for enhanced MSn functionality. Int. J. Mass Spectrom. 2011, 306 (2-3), 114-122. 77. Soparawalla, S.; Tadjimukhamedov, F. K.; Wiley, J. S.; Ouyang, Z.; Cooks, R. G., In situ analysis of agrochemical residues on fruit using ambient ionization on a handheld mass spectrometer. Analyst 2011, 136 (21), 4392-4396. 78. Wang, H.; Manicke, N. E.; Yang, Q. A.; Zheng, L. X.; Shi, R. Y.; Cooks, R. G.; Ouyang, Z., Direct Analysis of Biological Tissue by Paper Spray Mass Spectrometry. Analytical Chemistry 2011, 83 (4), 1197-1201. 79. Xu, W.; Chappell, W. J.; Ouyang, Z., Modeling of ion transient response to dipolar AC excitation in a quadrupole ion trap. International Journal of Mass Spectrometry 2011, 308 (1), 49-55. 80. Xu, W.; Maas, J. B.; Boudreau, F. J.; Chappell, W. J.; Ouyang, Z., Nondestructive Ion Trap Mass Analysis at High Pressure. Analytical Chemistry 2011, 83 (3), 685-689. 81. Chen, T. C.; Xu, W.; Garimella, S.; Ouyang, Z., Study of the efficiency for ion transfer through bent capillaries. Journal of Mass Spectrometry 2012, 47 (11), 1466-1472. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 8 of 23

82. Dalgleish, J. K.; Hou, K. Y.; Ouyang, Z.; Cooks, R. G., In Situ Explosive Detection Using a Miniature Plasma Ion Source and a Portable Mass Spectrometer. Analytical Letters 2012, 45 (11), 1440-1446. 83. Du, Y. M.; Xu, W.; Ouyang, Z., Self-correlation method for processing random phase signals in Fourier Transform Mass Spectrometry. International Journal of Mass Spectrometry 2012, 325, 73-79. 84. Espy, R. D.; Manicke, N. E.; Ouyang, Z.; Cooks, R. G., Rapid analysis of whole blood by paper spray mass spectrometry for point-of-care therapeutic drug monitoring. Analyst 2012, 137 (10), 2344-2349. 85. Espy, R. D.; Muliadi, A. R.; Ouyang, Z.; Cooks, R. G., Spray mechanism in paper spray ionization. International Journal of Mass Spectrometry 2012, 325, 167-171. 86. Garimella, S.; Xu, W.; Huang, G. M.; Harper, J. D.; Cooks, R. G.; Ouyang, Z., Gas-flow assisted ion transfer for mass spectrometry. Journal of Mass Spectrometry 2012, 47 (2), 201-207. 87. Malaj, N.; Ouyang, Z.; Sindona, G.; Cooks, R. G., Analysis of pesticide residues by leaf spray mass spectrometry. Analytical Methods 2012, 4 (7), 1913-1919. 88. Tadjimukhamedov, F. K.; Huang, G. M.; Ouyang, Z.; Cooks, R. G., Rapid detection of urushiol allergens of Toxicodendron genus using leaf spray mass spectrometry. Analyst 2012, 137 (5), 1082-1084. 89. Xiong, X. C.; Fang, X.; Ouyang, Z.; Jiang, Y.; Huang, Z. J.; Zhang, Y. K., Feature Extraction Approach for Mass Spectrometry Imaging Data Using Non-negative Matrix Factorization. Chinese Journal of Analytical Chemistry 2012, 40 (5), 663-669. 90. Xiong, X. C.; Xu, W.; Eberlin, L. S.; Wiseman, J. M.; Fang, X.; Jiang, Y.; Huang, Z. J.; Zhang, Y. K.; Cooks, R. G.; Ouyang, Z., Data Processing for 3D Mass Spectrometry Imaging. Journal of the American Society for Mass Spectrometry 2012, 23 (6), 1147-1156. 91. Xiong, X. C.; Xu, W.; Fang, X.; Deng, Y. L.; Ouyang, Z., Accelerated Simulation Study of Space Charge Effects in Quadrupole Ion Traps Using GPU Techniques. Journal of the American Society for Mass Spectrometry 2012, 23 (10), 1799-1807. 92. Yang, Q.; Manicke, N. E.; Wang, H.; Petucci, C.; Cooks, R. G.; Ouyang, Z., Direct and quantitative analysis of underivatized acylcarnitines in serum and whole blood using paper spray mass spectrometry. Analytical and Bioanalytical Chemistry 2012, 404 (5), 1389-1397. 93. Yang, Q.; Wang, H.; Maas, J. D.; Chappell, W. J.; Manicke, N. E.; Cooks, R. G.; Ouyang, Z., Paper spray ionization devices for direct, biomedical analysis using mass spectrometry. International Journal of Mass Spectrometry 2012, 312, 201-207. 94. Zhang, J. I.; Li, X.; Ouyang, Z.; Cooks, R. G., Direct analysis of steviol glycosides from Stevia leaves by ambient ionization mass spectrometry performed on whole leaves. Analyst 2012, 137 (13), 3091-3098. 95. Zhang, Z. P.; Cooks, R. G.; Ouyang, Z., Paper spray: a simple and efficient means of analysis of different contaminants in foodstuffs. Analyst 2012, 137 (11), 2556-2558. 96. Zhang, Z. P.; Xu, W.; Manicke, N. E.; Cooks, R. G.; Ouyang, Z., Silica Coated Paper Substrate for Paper- Spray Analysis of Therapeutic Drugs in Dried Blood Spots. Analytical Chemistry 2012, 84 (2), 931-938. 97. Badu-Tawiah, A. K.; Eberlin, L. S.; Ouyang, Z.; Cooks, R. G., Chemical Aspects of the Extractive Methods of Ambient Ionization Mass Spectrometry. Annual Review of Physical Chemistry, Vol 64 2013, 64, 481-505. 98. Chen, C. H.; Lin, Z. Q.; Garimella, S.; Zheng, L. X.; Shi, R. Y.; Cooks, R. G.; Ouyang, Z., Development of a Mass Spectrometry Sampling Probe for Chemical Analysis in Surgical and Endoscopic Procedures. Analytical Chemistry 2013, 85 (24), 11843-11850. 99. Chen, T. C.; Ouyang, Z., Synchronized Discharge Ionization for Analysis of Volatile Organic Compounds Using a Hand-Held Ion Trap Mass Spectrometer. Analytical Chemistry 2013, 85 (3), 1767-1772. 100. Dalgleish, J. K.; Wleklinski, M.; Shelley, J. T.; Mulligan, C. C.; Ouyang, Z.; Cooks, R. G., Arrays of low- temperature plasma probes for ambient ionization mass spectrometry. Rapid Communications in Mass Spectrometry 2013, 27 (1), 135-142. 101. Garimella, S.; Zhou, X. Y.; Ouyang, Z., Simulation of Rarefied Gas Flows in Atmospheric Pressure Interfaces for Mass Spectrometry Systems. Journal of the American Society for Mass Spectrometry 2013, 24 (12), 1890- 1899. 102. Jjunju, F. P. M.; Li, A. Y.; Badu-Tawiah, A.; Wei, P.; Li, L. F.; Ouyang, Z.; Roqan, I. S.; Cooks, R. G., In situ analysis of corrosion inhibitors using a portable mass spectrometer with paper spray ionization. Analyst 2013, 138 (13), 3740-3748. 103. Li, G. T.; Li, X.; Ouyang, Z.; Cooks, R. G., Carbon-Carbon Bond Activation in Saturated Hydrocarbons by Field-Assisted Nitrogen Fixation. Angewandte Chemie-International Edition 2013, 52 (3), 1040-1043. 104. Liu, J. J.; Cooks, R. G.; Ouyang, Z., Enabling Quantitative Analysis in Ambient Ionization Mass Spectrometry: Internal Standard Coated Capillary Samplers. Analytical Chemistry 2013, 85 (12), 5632-5636. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 9 of 23

105. Liu, J. J.; Ouyang, Z., Mass spectrometry imaging for biomedical applications. Analytical and Bioanalytical Chemistry 2013, 405 (17), 5645-5653. 106. Ren, Y.; Liu, J. J.; Li, L. F.; McLuckey, M. N.; Ouyang, Z., Direct mass spectrometry analysis of untreated samples of ultralow amounts using extraction nano-electrospray. Analytical Methods 2013, 5 (23), 6686-6692. 107. Ren, Y.; Wang, H.; Liu, J. J.; Zhang, Z. P.; McLuckey, M. N.; Ouyang, Z., Analysis of Biological Samples Using Paper Spray Mass Spectrometry: An Investigation of Impacts by the Substrates, Solvents and Elution Methods. Chromatographia 2013, 76 (19-20), 1339-1346. 108. Shen, L. H.; Zhang, J.; Yang, Q.; Manicke, N. E.; Ouyang, Z., High throughput paper spray mass spectrometry analysis. Clinica Chimica Acta 2013, 420, 28-33. 109. Su, Y.; Wang, H.; Liu, J. J.; Wei, P.; Cooks, R. G.; Ouyang, Z., Quantitative paper spray mass spectrometry analysis of drugs of abuse. Analyst 2013, 138 (16), 4443-4447. 110. Wang, H.; Ren, Y.; McLuckey, M. N.; Manicke, N. E.; Park, J.; Zheng, L. X.; Shi, R. Y.; Cooks, R. G.; Ouyang, Z., Direct Quantitative Analysis of Nicotine Alkaloids from Biofluid Samples using Paper Spray Mass Spectrometry. Analytical Chemistry 2013, 85 (23), 11540-11544. 111. Zhang, Z. P.; Gong, X. Y.; Zhang, S. C.; Yang, H. J.; Shi, Y. M.; Yang, C. D.; Zhang, X. R.; Xiong, X. C.; Fang, X.; Ouyang, Z., Observation of Replacement of Carbon in Benzene with Nitrogen in a Low-Temperature Plasma. Scientific Reports 2013, 3. 112. Chen, C.-H.; Chen, T.-C.; Zhou, X.; Kline-Schoder, R.; Sorensen, P.; Cooks, R. G.; Ouyang, Z., Design of Portable Mass Spectrometers with Handheld Probes: Aspects of the Sampling and Miniature Pumping Systems. Journal of The American Society for Mass Spectrometry 2014, 26 (2), 240-247. 113. Espy, R. D.; Teunissen, S. F.; Manicke, N. E.; Ren, Y.; Ouyang, Z.; van Asten, A.; Cooks, R. G., Paper Spray and Extraction Spray Mass Spectrometry for the Direct and Simultaneous Quantification of Eight Drugs of Abuse in Whole Blood. Analytical Chemistry 2014, 86 (15), 7712-7718. 114. Hendricks, P. I.; Dalgleish, J. K.; Shelley, J. T.; Kirleis, M. A.; McNicholas, M. T.; Li, L. F.; Chen, T. C.; Chen, C. H.; Duncan, J. S.; Boudreau, F.; Noll, R. J.; Denton, J. P.; Roach, T. A.; Ouyang, Z.; Cooks, R. G., Autonomous in Situ Analysis and Real-Time Chemical Detection Using a Backpack Miniature Mass Spectrometer: Concept, Instrumentation Development, and Performance. Analytical Chemistry 2014, 86 (6), 2900-2908. 115. Li, L.; Zhou, X.; Hager, J. W.; Ouyang, Z., High efficiency tandem mass spectrometry analysis using dual linear ion traps. Analyst 2014, 139 (19), 4779-4784. 116. Li, L. F.; Chen, T. C.; Ren, Y.; Hendricks, P. I.; Cooks, R. G.; Ouyang, Z., Mini 12, Miniature Mass Spectrometer for Clinical and Other Applications-Introduction and Characterization. Analytical Chemistry 2014, 86 (6), 2909-2916. 117. Lin, Z. Q.; Tan, L.; Garimella, S.; Li, L. F.; Chen, T. C.; Xu, W.; Xia, Y.; Ouyang, Z., Characterization of a DAPI-RIT-DAPI System for Gas-Phase Ion/Molecule and Ion/Ion Reactions. Journal of the American Society for Mass Spectrometry 2014, 25 (1), 48-56. 118. Park, J.; Zheng, L.; Marquis, A.; Walls, M.; Duerstock, B.; Pond, A.; Vega-Alvarez, S.; Wang, H.; Ouyang, Z.; Shi, R., Neuroprotective role of hydralazine in rat spinal cord injury-attenuation of acrolein-mediated damage. Journal of Neurochemistry 2014, 129 (2), 339-349. 119. Pulliam, C. J.; Bain, R. M.; Wiley, J. S.; Ouyang, Z.; Cooks, R. G., Mass Spectrometry in the Home and Garden. Journal of The American Society for Mass Spectrometry 2014, 26 (2), 224-230. 120. Ren, Y.; McLuckey, M. N.; Liu, J.; Ouyang, Z., Direct Mass Spectrometry Analysis of Biofluid Samples Using Slug-Flow Microextraction Nano-Electrospray Ionization. Angewandte Chemie International Edition 2014, 53 (51), 14124-14127. 121. Wu, W.; Lee, S. Y.; Wu, X. B.; Tyler, J. Y.; Wang, H.; Ouyang, Z.; Park, K.; Xu, X. M.; Cheng, J. X., Neuroprotective ferulic acid (FA)-glycol chitosan (GC) nanoparticles for functional restoration of traumatically injured spinal cord. Biomaterials 2014, 35 (7), 2355-2364. 122. Xu, W.; Li, L.; Zhou, X.; Ouyang, Z., Ion Sponge: A 3-Dimentional Array of Quadrupole Ion Traps for Trapping and Mass-Selectively Processing Ions in Gas Phase. Analytical Chemistry 2014, 86 (9), 4102-4109. 123. Zhou, X.; Liu, J.; Cooks, R. G.; Ouyang, Z., Development of miniature mass spectrometry systems for bioanalysis outside the conventional laboratories. Bioanalysis 2014, 6 (11), 1497-508. 124. Zhou, X.; Ouyang, Z., Flowing gas in mass spectrometer: method for characterization and impact on ion processing. Analyst 2014, 139 (20), 5215-5222. 125. Chen, C.-H.; Lin, Z.; Tian, R.; Shi, R.; Cooks, R. G.; Ouyang, Z., Real-Time Sample Analysis Using a Sampling Probe and Miniature Mass Spectrometer. Analytical Chemistry 2015, 87 (17), 8867-8873. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 10 of 23

126. He, M.; Xue, Z.; Zhang, Y.; Huang, Z.; Fang, X.; Qu, F.; Ouyang, Z.; Xu, W., Development and Characterizations of a Miniature Capillary Electrophoresis Mass Spectrometry System. Analytical Chemistry 2015, 87 (4), 2236-2241. 127. Ma, Q.; Bai, H.; Li, W.; Wang, C.; Cooks, R. G.; Ouyang, Z., Rapid analysis of synthetic cannabinoids using a miniature mass spectrometer with ambient ionization capability. Talanta 2015, 142, 190-196. 128. Ren, Y.; Chiang, S.; Zhang, W.; Wang, X.; Lin, Z.; Ouyang, Z., Paper-capillary spray for direct mass spectrometry analysis of biofluid samples. Analytical and Bioanalytical Chemistry 2015, 408 (5), 1385-1390. 129. Wei, Y. Z.; Bian, C. J.; Ouyang, Z.; Xu, W., A pulsed pinhole atmospheric pressure interface for simplified mass spectrometry instrumentation with enhanced sensitivity. Rapid Communications in Mass Spectrometry 2015, 29 (8), 701-706. 130. Chen, Q.-H.; Ouyang, Z.-J.; Zhao, D.; Wang, D.-J.; Li, B., Effects of Yishen Tonglong Capsules on sex hormone levels in mice with benign prostatic hyperplasia. Zhonghua nan ke xue = National journal of andrology 2016, 22 (11), 1011-1015. 131. Chen, Z.; Park, J.; Butler, B.; Acosta, G.; Vega-Alvarez, S.; Zheng, L.; Tang, J.; McCain, R.; Zhang, W.; Ouyang, Z.; Cao, P.; Shi, R., Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury. Journal of Neurochemistry 2016, 138 (2), 328-338. 132. Du, Y. M.; Hu, Y.; Xia, Y.; Ouyang, Z., Power Normalization for Mass Spectrometry Data Analysis and Analytical Method Assessment. Analytical Chemistry 2016, 88 (6), 3156-3163. 133. Ferreira, C. R.; Yanne, K. E.; Jarmusch, A. K.; Pirro, V.; Ouyang, Z.; Cooks, R. G., Ambient Ionization Mass Spectrometry for Point-of-Care Diagnostics and Other Clinical Measurements. Clinical Chemistry 2016, 62 (1), 99-110. 134. Lin, Z.; Tan, L.; Yang, Y.; Dai, M.; Turecek, F.; Ouyang, Z.; Xia, Y., Gas-phase reactions of cyclopropenylidene with protonated alkyl amines. Analyst 2016, 141 (8), 2412-2417. 135. Ma, Q.; Bai, H.; Li, W.; Wang, C.; Li, X.; Cooks, R. G.; Ouyang, Z., Direct identification of prohibited substances in cosmetics and foodstuffs using ambient ionization on a miniature mass spectrometry system. Analytica Chimica Acta 2016, 912, 65-73. 136. Ma, X.; Chong, L.; Tian, R.; Shi, R.; Hu, T. Y.; Ouyang, Z.; Xia, Y., Identification and quantitation of lipid C=C location isomers: A shotgun lipidomics approach enabled by photochemical reaction. Proceedings of the National Academy of Sciences of the United States of America 2016, 113 (10), 2573-2578. 137. Ma, X.; Ouyang, Z., Ambient ionization and miniature mass spectrometry system for chemical and biological analysis. Trac-Trends in Analytical Chemistry 2016, 85, 10-19. 138. Ma, X.; Zhao, X.; Li, J.; Zhang, W.; Cheng, J.-X.; Ouyang, Z.; Xia, Y., Photochemical Tagging for Quantitation of Unsaturated Fatty Acids by Mass Spectrometry. Analytical Chemistry 2016, 88 (18), 8931-8935. 139. Pulliam, C. J.; Wei, P.; Snyder, D. T.; Wang, X.; Ouyang, Z.; Pielak, R. M.; Cooks, R. G., Rapid discrimination of bacteria using a miniature mass spectrometer. Analyst 2016, 141 (5), 1633-1636. 140. Ren, Y.; Chiang, S.; Zhang, W.; Wang, X.; Lin, Z.; Ouyang, Z., Paper-capillary spray for direct mass spectrometry analysis of biofluid samples. Analytical and Bioanalytical Chemistry 2016, 408 (5), 1385-1390. 141. Snyder, D. T.; Pulliam, C. J.; Ouyang, Z.; Cooks, R. G., Miniature and Fieldable Mass Spectrometers: Recent Advances. Analytical Chemistry 2016, 88 (1), 2-29. 142. Wang, X.; Zhou, X.; Zheng, O., Direct Analysis of Nonvolatile Chemical Compounds on Surfaces Using a Hand-Held Mass Spectrometer with Synchronized Discharge Ionization Function. Analytical Chemistry 2016, 88 (1), 826-831. 143. Zhao, Y.; Wei, Z.; Zhao, H.; Jia, J.; Chen, Z.; Zhang, S.; Ouyang, Z.; Ma, X.; Zhang, X., In Situ Ion- Transmission Mass Spectrometry for Paper-Based Analytical Devices. Analytical Chemistry 2016, 88 (22), 10805-10810. 144. Zhou, X.; Ouyang, Z., Following the Ions through a Mass Spectrometer with Atmospheric Pressure Interface: Simulation of Complete Ion Trajectories from Ion Source to Mass Analyzer. Analytical Chemistry 2016, 88 (14), 7033-7040. 145. Pu, F.; Zhang, W.; Bateman, K. P.; Liu, Y.; Helmy, R.; Ouyang, Z., Using miniature MS system with automatic blood sampler for preclinical pharmacokinetics study. Bioanalysis 2017, 9 (21), 1633-1641. 146. Pu, F.; Zhang, W.; Han, C.; Ouyang, Z., Fast quantitation of pyrazole fungicides in wine by ambient ionization mass spectrometry. Analytical Methods 2017, 9 (34), 5058-5064. 147. Zhang, W.; Wang, X.; Xia, Y.; Ouyang, Z., Ambient Ionization and Miniature Mass Spectrometry Systems for Disease Diagnosis and Therapeutic Monitoring. Theranostics 2017, 7 (12), 2968-2981. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 11 of 23

148. Cao, W.; Ma, X.; Li, Z.; Zhou, X.; Ouyang, Z., Locating Carbon-Carbon Double Bonds in Unsaturated Phospholipids by Epoxidation Reaction and Tandem Mass Spectrometry. Analytical Chemistry 2018, 90 (17), 10286-10292. 149. Chiang, S.; Zhang, W.; Ouyang, Z., Paper spray ionization mass spectrometry: recent advances and clinical applications. Expert Review of Proteomics 2018, 15 (10), 781-789. 150. Guo, X.; Bai, H.; Lv, Y.; Xi, G.; Li, J.; Ma, X.; Ren, Y.; Zheng, O.; Ma, Q., Rapid identification of regulated organic chemical compounds in toys using ambient ionization and a miniature mass spectrometry system. Talanta 2018, 180, 182-192. 151. Li, M.; Li, K.; Ouyang, Z., Application of CAN bus in development of mass spectrometer. Metallurgical Analysis 2018, 38 (4), 22-26. 152. Li, M.; Tang, X.; Li, K.; Ouyang, Z., Development and application of one kind of ion lens power supply for mass spectrometer. Metallurgical Analysis 2018, 38 (7), 63-67. 153. Liu, S.; Ouyang, Z.; Chong, A. M.; Wang, H., Neighborhood Environment, Residential Satisfaction, and Depressive Symptoms Among Older Adults in Residential Care Homes. International Journal of Aging & Human Development 2018, 87 (3), 268-288. 154. Ren, Y.; Zhang, W.; Lin, Z.; Bushman, L. R.; Anderson, P. L.; Ouyang, Z., In-capillary microextraction for direct mass spectrometry analysis of biological samples. Talanta 2018, 189, 451-457. 155. Su, Y.; Ma, X.; Ouyang, Z., Rapid screening of multi-class antimicrobial residues in food of animal origin by paper spray mass spectrometry. International Journal of Mass Spectrometry 2018, 434, 233-239. 156. Tang, F.; Guo, C.; Ma, X.; Zhang, J.; Su, Y.; Tian, R.; Shi, R.; Xia, Y.; Wang, X.; Ouyang, Z., Rapid In Situ Profiling of Lipid C=C Location Isomers in Tissue Using Ambient Mass Spectrometry with Photochemical Reactions. Analytical Chemistry 2018, 90 (9), 5612-5619. 157. Zhou, X.; Liu, X.; Cao, W.; Wang, X.; Li, M.; Qiao, H.; Ouyang, Z., Study of In-Trap Ion Clouds by Ion Trajectory Simulations. Journal of the American Society for Mass Spectrometry 2018, 29 (2), 223-229. 158. Zhou, X.; Liu, X.; Chiang, S.; Cao, W.; Li, M.; Ouyang, Z., Stimulated Motion Suppression (STMS): a New Approach to Break the Resolution Barrier for Ion Trap Mass Spectrometry. Journal of the American Society for Mass Spectrometry 2018, 29 (8), 1738-1744. 159. Liu, X.; Wang, X.; Bu, P.; Zhou, X.; Zheng, O., Tandem Analysis by a Dual-Trap Miniature Mass Spectrometer. Analytical Chemistry 2019, 91 (2), 1391-1398. 160. Pu, F.; Alfaro, C. M.; Pirro, V.; Xie, Z.; Ouyang, Z.; Cooks, R. G., Rapid determination of isocitrate dehydrogenase mutation status of human gliomas by extraction nanoelectrospray using a miniature mass spectrometer. Analytical and bioanalytical chemistry 2019. 161. Pu, F.; Chiang, S.; Zhang, W.; Ouyang, Z., Direct sampling mass spectrometry for clinical analysis. Analyst 2019, 144 (4), 1034-1051. 162. Zhang, W.; Chiang, S.; Li, Z.; Chen, Q.; Xia, Y.; Ouyang, Z., A Polymer Coating Transfer Enrichment Method for Direct Mass Spectrometry Analysis of Lipids in Biofluid Samples. Angewandte Chemie International Edition 2019, 58 (0), 1-7. 163. Zhang, W.; Zhang, D.; Chen, Q.; Wu, J.; Ouyang, Z.; Xia, Y., Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers. Nature Communications 2019, 10 (1), 79. 164. Zou, R.; Cao, W.; Chong, L.; Hua, W.; Xu, H.; Mao, Y.; Page, J.; Shi, R.; Xia, Y.; Hu, T. Y.; Zhang, W.; Ouyang, Z., Point-of-Care Tissue Analysis Using Miniature Mass Spectrometer. Analytical Chemistry 2019, 91 (1), 1157-1163.

INVITED LECTURES and KEYNOTE SPEECHES 1. “Instrumentation in Mass Spectrometry,” Jilin University, Jilin, China, August 2002. 2. “Mass Spectrometry,” Peking University, Beijing, China, September 2002. 3. “Ion Trap Mass Spectrometry,” National Center for Certified Reference Materials, Beijing, China, September 2002. 4. “New Mass Spectrometers: Miniature, Multiplexed and High Resolution Ion Traps,” Jilin University, Jilin, China, October 2003. 5. “Miniature and Preparative MS,” Department of Chemistry, Virginia Commonwealth University, Richmond, VA, April 2005. 6. “Instrumentation Development in University: Challenges and Exploration,” National Science Foundation Workshop, “Instrumentation for Biological Sciences,” Tucson, AZ, April 20-21, 2006. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 12 of 23

7. “Miniature Mass Spectrometry,” American Society for Mass Spectrometry Fall Workshop, The Present & Future of Quadrupole Ion Trap Mass Spectrometry, San Diego, CA, November 9-10, 2006. 8. “DESI and Miniature Mass Spectrometry,” Firmenich 2007 World Analytical Meeting, Firmenich, Princeton, NJ, March 21, 2007. 9. “Miniature Mass Spectrometry,” Center for Process Analytical Chemistry Spring Meeting, University of Washington, May 2007. 10. “Miniature Mass Spectrometry,” School of Aerospace, Tsinghua University, Beijing, China, October 17, 2007. 11. “Miniature and Ambient Mass Spectrometry,, Department of Chemistry, Peking University, Beijing, China, October 18, 2007. 12. “Miniature Ambient Mass Spectrometry,” Department of Chemistry, Northern Illinois University, October 29, 2007. 13. “Low Temperature Plasma Probe Miniature Mass Spectrometer and Tissue Imaging,” Academia Sinica, Taiwan, June 26, 2008. 14. “Development of Analytical Instrument,” Department of Chemistry, Tsinghua University, Beijing, China, November 2008. 15. “Mass Spectrometer and Analytical Instrumentation Research,” National Natural Science Foundation of China Workshop “Mass Spectrometry Instrumentation,” Beijing, China, November 2008. 16. “Miniature Ambient Mass Spectrometry,” Department of Precision Instruments and Mechanology, Tsinghua University, Beijing, China, July 2009. 17. “Development of Miniature Mass Spectrometry Analysis Systems with Direct Sampling Capability,” Department of Chemistry, Ohio University, October 5, 2009. 18. “Trace Analysis using Ambient Ionization on Miniature Mass Spectrometers,” DHS Center of Excellence, DHS Explosive Detection Workshop, University of Rhode Island, October 9, 2009. 19. “Direct Sampling Ionization and Miniature Mass Spectrometers for Biomedical Analysis,” Medical Center, University of Nebraska, October 14, 2009. 20. Analytical Chemistry Division Seminar “Origami and Tricorder for Chemical Analysis Miniaturization of Mass Analysis Systems,” Department of Chemistry, University of California Riverside, November 18, 2010. 21. Analytical Chemistry Division Seminar “Technology Development and Biomedical Applications of Miniature MS Systems,” Department of Chemistry, Indiana University, February 14, 2011. 22. Frontiers in Chemistry Lecture “Miniature Mass Spectrometry Analysis Systems and Their Applications”, Department of Chemistry, Brigham Young University, March 17, 2011. 23. “Innovations in Portable Mass Spectrometry Analysis Systems,” Dow AgroSciences, Indianapolis, IN, April 14, 2011. 24. “Mass Spectrometry Imaging and Miniature MS Instruments for Clinical Diagnostics”, Department of Biomedical Engineering, Tsinghua University, Beijing, China, July 05, 2011 25. Lecture, “Miniature Mass Spectrometry System and Analytical Methods”, Mass Spectrometry Workshop by www.instrument.com.cn, November, 2011 26. “Marching Toward the Point of Care: Miniature Mass Spectrometers and Ambient Ionization for Direct Analysis of Biological Samples”, The Methodist Hospital Research Institute, November 9, 2011 27. Invited seminar, “Miniaturization of Mass Spectrometry Systems – Concepts and Technologies ”, Department of Precision Instruments and Mechanology, Tsinghua University, July, 2012 28. Curt Brunnee Award Lecture, “ ”, 19th International Mass Spectrometry Conference, Kyoto, Japan, September 16, 2012 29. Departmental Colloquium, “Beyond Chemical Analysis - Instrumentation Development for Mass Spectrometry”, Department of Chemistry, October 2012, West Virginia University 30. Invited Lecture, “In-Situ Mass Spectrometry Analysis: Instrumentation and Methods”, College of Life Science, Beijing Institute of Science and Technology, December 2012 31. Invited Speech, “Development of Mass Spectrometry Analysis Systems for In-Situ Chemical and Biological Analysis”, Symposium on Advanced Technologies in Mass Spectrometry, University of Yamanashi, December 3, 2012 32. “Applications of Miniature Mass Spectrometry System in Food Safety and Biomedicine”, Chinese Academy of Inspection and Quarantine, December 2012 33. Invited Speech at 9th North American FT MS Conference, “Data processing and Ion Trajectory Simulations For Design Of Mass Spectrometer”, National High Magnetic Field Laboratory, Florida State University, April 28- May 1, 2013 34. Invited Speech, Institute of Medicine and National Research Council Workshop Strategies for Cost-Effective and Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 13 of 23

Flexible Biodetection Systems that Ensure Timely and Accurate Information for Public Health Officials, “Miniature Ambient Ionization Mass Spectrometry System For Analysis of Microorganisms”, June 25-26, 2013 35. Lecture, Review of 2013 ASMS Conference by Chinese Mass Spectrometry Society, “Mass Spectrometry Instrumentation”, July 8, 2013 36. Keynote Speech, “Electro-Hydrodynamic Effects In MS Systems and Design Of Instruments with New Configurations”, 15th International Beijing Conference and Exhibition on Instrumental Analysis, October 23-26, 2013 37. Invited Seminar, “Development of point-of-care diagnostic tools using mass spectrometry technologies”, Houston Methodist Research Institute, Houston, Feb 21, 2014 38. Keynote Speech, “Development of Mass Spectrometry Technologies for Biological Analysis and Point-of-Care Diagnosis”, 62nd Annual Conference of The Mass Spectrometry Society of Japan, Osaka, Japan, May 16, 2014 39. Invited Lecture, “Evolution of Point-of-Care Mass Spectrometry Analytical Systems: Physics, Instrumentation and Applications”, Osaka University, Osaka, Japan, May 17, 2014

CONFERENCE PRESENTATIONS 1. Z. Ouyang, "Miniaturization Of Ion Trap Mass Spectrometers", 2003 Beijing Conference and Exhibition on Instrumental Analysis, Beijing, China, October 2003, 2. Z. Ouyang, T. Takats, T. Blake, B. Gologan, A. Guymon, J. M. Wiseman, J. C. Oliver, V. J. Davisson and R. G. Cooks, "Protein Microarrays by Ion Soft Landing: Preparative Mass Spectrometry", Gordon Conference on Biological Molecules in the Gas Phase, New London, CT, July 20-25 2003, 3. Z. Ouyang, "Solutions to Trace Detection of Illicit Substances: Miniature Mass Spectrometry and Ambient DESI Ionization", Gordon Research Conference-Detecting Illicit Substances: Explosives & Drugs, Les Diablerets, Switzerland, August 28 – September 2 2005, 4. Z. Ouyang, "Rectilinear Ion Trap Mass Spectrometers", 54th ASMS Conference on Mass Spectrometry, Seattle, WA, May 28 - June 1 2006, 5. Z. Ouyang, "On the Horizon of Mass Spectrometry: Ambient MS, Miniature MS, Preparative MS and Others", 1st National Conference on Bioanalytical Chemistry, Beijing, China, March 24-26 2006, 6. Z. Ouyang, L. Gao, S. Kothari, Q. Song and R. G. Cooks, "Handheld Rectilinear Ion Trap Mass Spectrometer", 57th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Orlando, Florida, March 12 - 17 2006, 2260-8 7. Z. Ouyang, "Miniature Mass Spectrometry", 2007 Beijing Conference and Exhibition on Instrumental Analysis,, Beijing, China, October 18 – 21 2007, 8. Z. Ouyang, "Miniature Ambient Mass Spectrometry", BCEIA 2007, Beijing, China, October 18-21 2007, Mass Spectrometry. 9. Z. Ouyang, L. Gao, J. D. Harper and R. G. Cooks, "Miniature Mass Spectrometry For Clinical Diagnostics And ersonal Healthcare", BMES 2007 Annual Fall Meeting, Los angeles, CA, US, September 26-29 2007, 1499. 10. Z. Ouyang, L. Gao, Q. Song, R. S. Milks, G. E. Patterson and R. G. Cooks, "Miniature Mass Spectrometry", 58th Pittsburgh conferece on Analytical Chemistry and Appied Spectromscopy, Chicago, Illinois, USA, February 25 - March 2 2007, 1850 -1851. 11. Z. Ouyang, A. L. Dill, T. Kistler, D. R. Ifa, N. E. Manicke and R. G. Cooks, "Lipid analysis and tissue imaging using DESI-MS", DICP symposium (XIX) on Frontier of Bioanalytical Techniques: Challenge of Metabonomics and other -omics, Dalian, China, November 29-30 2008, 12. Z. Ouyang, L. Gao, J. Harper, Q. Song, W. Xu and R. G. Cooks, "How far can ion trap miniaturization go", 56th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, US, June 1-5 2008, MOCpm 3:10pm. 13. Z. Ouyang, L. Gao, J. D. Harper, A. C. Nicholas, M. A. Visbal, G. Huang and R. G. Cooks, "In-situ analysis using ambient ionization and miniature mass spectrometry", Applied Pharmaceutical Analysis Conference, Boston, MA, September 15-19 2008, 14. Z. Ouyang, L. Gao, C. C. Mulligan and R. G. Cooks, "Breaking the limit of pumping capacity: portable mass spectrometers with atmospheric pressure ionization sources", 59th Pittsburgh Conference an Analytical Chemistry and Applied Spectroscopy, New Orleans, LA, US, March 1-7 2008, 2470-2474. 15. Z. Ouyang, J. Harper, G. Huang, Y. Xia, X. Zhang and R. G. Cooks, "Sampling ionizaiton and miniaturizaiton of mass spectrometer for biomedical analysis ", 2nd National Conference on Bioanalytical Chemistry, Beijing, March 28-31 2008, 16. Z. Ouyang, J. D. Harper, A. C. Nicholas, L. Gao and R. G. Cooks, "Development of ambient sampling capability for miniature mass spectrometry", 2nd International Conference on the Chinese Mass Spectrometry, Taipei, Taiwan, June 26-27 2008, Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 14 of 23

17. Z. Ouyang, N. Manicke, A. Costa, D. Ifa and R. G. Cooks, "Tissue imaging using desorption electrospray ionization mass spectrometry", BMES 2008 Annual Fall Meeting, St. Louis, October 2-4 2008, 160. 18. Z. Ouyang, A. C. Nicholas, J. D. Harper, L. Gao, N. E. Manicke, M. A. Visbal, G. Huang and R. G. Cooks, "Ambient Sampling Ionization Methods and Miniature Ion Trap Mass Spectrometer for Fast and In situ Chemical Analysis", Eastern Analytical Symposium Somerset, NJ, US, November 17-20 2008, 558. 19. Z. Ouyang, W. Xu, L. Gao, Q. Song, A. C. Nicholas and R. G. Cooks, "Special modes of trapping, isolating and mass-analyzing ions using rectilinear ion traps", Asilomar Conference on Mass Spectrometry Pacific Grove, CA, October 10-13 2008, 20. Z. Ouyang, "In situ Analysis Using Miniature Mass Spectrometers with Direct Sampling Ionization Capability", Gordon Research Conference on Floral and Vegetative Volatitles 2009, Magdlen College, Oxford, UK, August 9-14 2009, 21. Z. Ouyang, H. Wang, J. Liu, M. A. V. Onufrak, W. Xu, N. E. Manicke, G. Huang and R. G. Cooks, "Miniature Mass Spectrometry Analysis Systems with Direct Sampling Capability ", ACS southern regional conference 2009, SAN JUAN, PUERTO RICO, October 21-24 2009, Applied Analytical Chemistry. 22. Z. Ouyang, "Development of Miniature Mass Spectrometry Analysis Systems ", LabAutomation2010, Palm Springs, CA, USA2010, January 23-27, 2010. 23. Z. Ouyang, R. G. Cooks, J. Liu, H. Wang, G. Huang and N. E. Manicke, "Development of mass spectrometry technologies for fast and autonomous chemical analysis", ACHEMASIA, Beijing, China, June1-4 2010, Laboratory Automation 24. Z. Ouyang, R. G. Cooks, H. Wang, J. Liu, N. E. Manicke and G. Huang, "Portable Mass Spectrometers vs. Portable Mass Spectrometry Analysis Laboratories", The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Orlando, Florida, Feburary 28 - March 5 2010, 25. W. Xu, W. Chappell, R. G. Cooks and Z. Ouyang, "Transient analysis of the ion motion inside an ion trap under dipolar AC excitation", 58th ASMS Conference on Mass Spectrometry and Allied Topics, Salt Lake City, Utah, May 23 - 27 2010, MOB am. 26. R. Espy, N. Manicke, Z. Ouyang and R. G. Cooks, "Paper Spray Mass Spectrometry as an Ambient, Quantitative method for Point of Care Therapeutic Drug Monitoring from Blood", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9 2011, TOF 09:50. 27. N. Manicke, R. Espy, Z. Ouyang and G. Cooks, "Rapid Analysis of Clinical Samples by Paper Spray: Toward Point of Care Testing by Mass Spectrometry", The Federation of Analytical Chemistry and Spectroscopy Societies Reno, NV, October 2-7 2011, 665. 28. N. Manicke, Z. Ouyang and R. G. Cooks, "Analysis of Carbohydrates and Other Hydrophilic Analytes by Paper Spray Mass Spectrometry", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9 2011, WOE 09:10. 29. Z. Ouyang, H. Wang, N. E. Manicke and R. G. Cooks, "Miniature Ion Trap Mass Spectrometry Systems for Biomedical Diagnosis", The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Atlanta, GA USA, March 13-18 2011, 30. Z. Ouyang, Z. Zhang, T. Chen, J. Dalgleish and R. Cooks, "Direct Analysis using Miniature Ion Trap Mass Spectrometers", The Federation of Analytical Chemistry and Spectroscopy Societies Reno, NV, October 2-7 2011, 727. 31. Z. Ouyang, Z. Zhang, J. Liu, H. Wang, Y. Du, N. E. Manicke and R. G. Cooks, "Solution For Specialized Mass Spectrometry Analysis: Paper Spray", Beijing Conference and Exhibition on Instrumental Analysis, Beijing, China, October 13-16 2011, 32. W. Xu, Z. Zhang and Z. Ouyang, "Ion Sponge: A 3-Dimentional Quadrupole Ion Trap Array for Ion Trapping, Sorting and Gas-Phase Ion Reactions", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9 2011, TOE 04:10. 33. T.-C. Chen, C.-H. Chen and Z. Ouyang, "Synchronized Discharge Ionization (SDI) for Analysis of VOC in Air Using Miniature Ion Trap Mass Spectrometer", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, TOC pm 2:50. 34. T.-C. Chen and Z. Ouyang, "Synchronized Discharge Ionization (SDI) for Analysis of VOCs in Air Using Handheld Ion Trap Mass Spectrometer", The Pittsburgh Conference on Analytical, Chemistry and Applied Spectroscopy, Orlando, FL, March 11-15 2012, 35. S. Garimella, W. Xu and Z. Ouyang, "Simulation of Transient Rarefied Gas Expansion for Discontinuous Atmospheric Pressure Interface (DAPI) Using Direct Simulation MonteCarlo (DSMC)", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, ThOF pm 2:30. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 15 of 23

36. P. I. Hendricks, J. Dalgleish, J. T. Shelley, T.-C. Chen, M. Kirleis, J. S. Duncan, M. McNicholas, L. Li, J. P. Denton, C.-H. Chen, Z. Ouyang and R. G. Cooks, "Backpack Mass Spectrometer with Hand-Held Sampling Probe for In-Field Analysis –Instrument Performance", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, TOC pm 3:10. 37. Z. Lin, L. Li, W. Xu, Y. Xia and Z. Ouyang, "A DAPI-RIT-DAPI System for In-Trap Gas Phase Reactions", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, TOC am 08:50. 38. N. Manicke, R. Espy, J. Liu, J. Hertig, Z. Ouyang and R. G. Cooks, "Analysis of Biological Samples by Paper Spray-MS: Toward Point of Care Mass Spectrometry", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, MOC am 08:50. 39. Z. Ouyang, "Miniature Mass Spectrometry Systems for Chemical Analysis", International Microwave Symposium Montreal, Canada, June 17-22 2012, WFK-2. 40. Z. Ouyang, T.-C. Chen, S. Garimella, W. Xu and R. G. Cooks, "Atmospheric Pressure Interface for Miniature Mass Spectrometers", The Pittsburgh Conference on Analytical, Chemistry and Applied Spectroscopy, Orlando, FL, March 11-15 2012, 41. Z. Ouyang, H. Wang, R. D. Espy, N. E. Manicke, Z. Zhang and R. G. Cooks, "Mass Spectrometry for Human Health and Security", The Pittsburgh Conference on Analytical, Chemistry and Applied Spectroscopy, Orlando, FL, March 11-15 2012, 42. Z. Ouyang, Z. Zhang, G. Huang, F. Tadjimukhamedov, J. G. Reyes, J. S. Wiley, S. Soparawalla and R. G. Cooks, "Foods Analysis with Ambient Ionization and Portable Instrumentation", Asilomar Conference of Mass Spectrometry, Asilomar, CA, October 5-9 2012, 43. Z. Ouyang, Z. Zhang, J. Liu, H. Wang, N. E. Manicke and R. G. Cooks, "Mass Spectrometry Analytical Systems for Point-of-Care Therapeutic Drug Monitoring", 4th World Chinese Mass Spectrometry Conference, Tainan, Taiwan, June 28 - July 1 2012, 44. Z. Lin, T.-C. Chen, L. Li, Y. Xia and Z. Ouyang, "Development of a Mass Spectrometer for Gas Phase Ion- Radical Reactions", 61st ASMS Conference on Mass Spectrometry and Allied Topics, Minneapolis, MN, June 9- 13 2013, TOA pm 2:50. 45. Z. Ouyang, "Mass Spectrometry Systems for Point-of-Care Applications", Midwestern University Analytical Chemistry Conference Notre Dame, IN, October 10-12 2013, 46. Z. Ouyang, R. G. Cooks, X. Zhou, S. Garimella, A. Chen, K. Hou, J. Dalgleish and P. Hendricks, "Gas Dynamics in Mass Spectrometry Systems and Design of MS Probes", Innovations in Mass Spectrometry Instrumentation Conference, Saint Petersburg, Russia, July 14-18 2013, 47. Z. Ouyang, L. Li, Y. Ren, T.-C. Chen and R. G. Cooks, "Miniature Ion Trap Mass Spectrometry System with Paper Spray for Biomedical Analysis", The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Philadelphia, PA, Mar. 17-21 2013, 48. Y. D. Xiaoyu Zhou, Xingchuang Xiong, Wei Xu and Zheng Ouyang, "Data Processing And Ion Trajectory Simulations For Design Of Mass Spectrometer", 9th North American FTMS Conference, Key West, FL, April 28 - May 1 2013, 49. R. G. C. Zheng Ouyang, Xiaoyu Zhou, Sandilya Garimella, Alex Chen, Keyong Hou, Jon Dalgleish, Paul Hendricks, "Gas Dynamics in Mass Spectrometry Systems And Design of MS Probes", Innovations in Mass Spectrometry Instrumentation Conference, Saint Petersburg, Russia, July 14-18 2013, 50. X. Z. Zheng OUYANG, Chien-Hsun CHEN, Linfan LI, Xiao WANG, R. Graham COOKS, "Electro- Hydrodynamic Effects In MS Systems and Design Of Instruments with New Configurations", Beijing Conference and Exhibition on Instrumental Analysis, Beijing, China, October 23-26 2013, 51. X. Z. Linfan Li, Zheng Ouyang, "Dual-Trap Configuration for High Efficiency Tandem Mass Spectrometry Analysis", 62nd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, MD, June 15-19 2014, TOB am 09:30. 52. Z. O. Xiao Wang, "Development of A Synchronized Discharge Ionization Probe for Direct Analysis of Non- volatile Chemicals on Surfaces Using Handheld Mass Spectrometers", 62nd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, MD, June 15-1 2014, MOB pm 02:30. 53. Y. S. Xiaoxiao Ma, Zheng Ouyang, Yu Xia, "Facile Determination of C=C Bonds within Lipids by On-Line Paternò-Büchi Reaction and Tandem Mass Spectrometry", 62nd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, MD, June 15-19 2014, ThOG pm 2:30. 54. M. M. Yue Ren, Zheng Ouyang, "Development of on-Cartridge Enzyme Activity Assay for Cholinesterase in Human Whole Blood using Paper Spray Mass Spectrometry", 62nd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, MD, June 15-19 2014, TOG 230. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 16 of 23

55. C.-H. C. Zheng Ouyang, Robert G Cooks, Linfan Li, Yue Ren, "Design and Development of Mass Spectrometry Devices for Point-of-Care Diagnosis", The Pittsburgh Conference on Analytical, Chemistry and Applied Spectroscopy, Chicago, Illinois, March 2-6 2014, 670-3 56. L. L. Zheng Ouyang, Yue Ren, Xiaoxiao Ma, Yu Xia, Robert G. Cooks, "Development of Mass Spectrometry Technologies for Biological Analysis and Point-of-Care Diagnosis", 62nd Annual Conference of The Mass Spectrometry Society of Japan, Osaka, Japan, May 14-16 2014, 3A-O2-1515.

OTHER CONFERENCE PROCEEDINGS 1. S. Sneckenberger, Z. Ouyang, E. Kao and P. W. Jagodzinski, "FTIR investigation of glass ionomer dental cements.", Abstracts of Papers of the American Chemical Society, 1997, 213, 157-PHYS. 2. J. M. Wells, W. R. Plass, G. E. Patterson, Z. Ouyang, E. R. Badman and R. G. Cooks, "Chemical Mass Shifts In Ion Trap Mass Spectrometry", 47th ASMS Conference on Mass Spectrometry and Allied Topics, Dallas, Texas, June 13 - 17 1999, WOC 10:35. 3. Z. Ouyang, V. Grill, H. Rohrs, P. D. Thomas and R. G. Cooks, "QoQoQ Tandem Mass Spectrometer for the Study of Ion/Surface Collision Processes", 48th ASMS Conference on Mass Spectrometry and Allied Topics, Long Beach, California, June 11 - 15 2000, WPA 031. 4. Z. Ouyang, M. Jemal and M. L. Powell, "Quantitative LC/MS/MS Method for Lactone and Lactonizable Hydroxy + + Acids: [M + H] vs. [M + NH4] As a Precursor Ion vis-a-vis the Need for Q1 Unit Mass Resolution or Chromatographic Seperation.", 48th ASMS Conference on Mass Spectrometry and Allied Topics, Long Beach, California, June 11 - 15 2000, WPD 166. 5. R. G. Cooks, L. Riter, Z. Takats, K. Koch, G. Patterson and Z. Ouyang, "Membrane Introduction Mass Spectrometry (MIMS) for On-Site Analysis", 52nd Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, New Orleans, LA, March 4-9 2001, 203. 6. R. G. Cooks, Z. Takats, A. Vilkov, E. J. Badman, G. Patterson, W. Plass and Z. Ouyang, "The Enabling Role of Instrumentation in Mass Spectrometry", 52nd Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, New Orleans, LA, March 4-9 2001, Wednesday Afternoon, Session 113, 836. 7. Z. Ouyang, L. Gianelli, J. Alvarez, V. Grill and R. G. Cooks, "Novel Instrument Design for the Study of Ion/Surface Collision Processes", 49th ASMS Conference on Mass Spectrometry and Allied Topics, Chicago, Illinois, May 27 - 31 2001, TPA 014. 8. Z. Ouyang, V. Grill, C. H. Doerge, H. Rohrs, J. Alvarez, P. D. Thomas and R. G. Cooks, "QoQoQ Tandem Mass Spectrometry for the Study of Ion/Surface Collision Processes", 52nd Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, New Orleans, LA, March 4 - 9 2001, Tuesday Afternoon, Session 203, 1944P. 9. R. G. Cooks, B. C. Laughlin, A. T. Gilchiest, A. Guymon, Z. Ouyang and J. Griep-Raming, "High Throughput Mass Spectrometry using Cylindrical Ion Trap Arrays", 53rd Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, New Orleans, LA, March 17-22 2002, Thursday Morning, Session 139, 997. 10. R. G. Cooks, B. C. Laughlin, A. T. Gilchiest, A. Guymon, Z. Ouyang and R. J. Noll, "Miniature Cylindrical Ion Traps and Ion Trap Arrays", 53rd Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, New Orleans, LA, March 17-22 2002, Monday Afternoon, Session 35, 227. 11. R. G. Cooks, B. C. Laughlin, A. Tabert, L. Mordoh, A. J. Guymon and Z. Ouyang, "Miniature Ion Trap Mass Spectrometers: Potential for Use with Laser Spectroscopy", 10th International Symposium on Laser Spectroscopy, Korean Atomic Energy Research Institute, Daejon, Korea, November 1 2002, 12. R. G. Cooks, F. E. Lytle, R. E. Santini and Z. Ouyang, "Instrumentation development as a platform for graduate education.", Abstracts of Papers of the American Chemical Society, 2002, 223, U64-U65. 13. R. G. Cooks, E. Nikolaev, B. C. Laughlin, A. G. Tabert, A. Guymon, Z. Ouyang, L. M. Riter and R. J. Noll, "Miniature Cylindrical Ion Traps and Ion Trap Arrays", Workshop-School "Mass Spectrometry in Chemical Physics, Biophysics and Environmental Sciences" Zvenigorod, Russia, April 23rd 2002, 14. G. Wu, Z. Ouyang, W. Plass and R. G. Cooks, "Geometry Optimization of the Cylindrical Ion Trap", 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, Florida, June 2 - 6 2002, ThPN 294. 15. T. Blake, Z. Ouyang, A. J. Guymon, S. Kothari, Z. Takats, B. Gologan and R. G. Cooks, "A Microarray Fabrication System Using Ion Soft-Landing in a Linear Ion Trap Mass Analyzer", 51st ASMS Conference on Mass Spectrometry and Allied Topics, Montreal, Quebec, Canada, June 8 - 12 2003, WPX 480. 16. R. G. Cooks, R. J. Noll, A. Makarov, W. Plass and Z. Ouyang, "Frontiers in Quadrupole Ion Traps", 51st ASMS Conference on Mass Spectrometry and Allied Topics, Montreal, Quebec, Canada, June 8 - 12 2003, WOAam 10:15. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 17 of 23

17. R. G. Cooks and Z. Ouyang, "Present and future technologies in mass spectrometry", Abstracts of Papers of the American Chemical Society, Mar 2003, 225 U137-U137. 18. R. G. Cooks, Z. Ouyang, Z. Takats, B. Gologan, T. M. Blake and V. J. Davisson, "Protein Chip Preparation by Soft-Landing of Mass-Selected, Multiply-Charged Ions", 16th International Mass Spectrometry Conference, Edinburgh, Scotland, September 1st 2003, 19. R. G. Cooks, Z. Ouyang, Z. Takats, S. Nanita, B. Gologan, T. Blake and A. Guymon, "Preparative Mass Spectrometry and the Origin of Homochirality", 10th International Beijing Conference and Exhibition on Instrumental Analysis, Beijing, China, 2003, 20. B. Gologan, Z. Takats, T. Blake, Z. Ouyang, V. J. Davisson and R. G. Cooks, "Self-Assembled Monolayers as Substrates for Laser Desorption: Analysis of Soft-Landed Proteins", 51st ASMS Conference on Mass Spectrometry and Allied Topics, Montreal, Quebec, Canada, June 8 - 12 2003, MPN 251. 21. Z. Ouyang and R. G. Cooks, "Rectilinear Ion Trap as a Miniature Mass Spectrometer", 16th International Mass Spectrometry Conference, Edinburgh, Scotland, September 1st 2003, 22. Z. Ouyang, G. Wu, H. Li, H. Chen, J. R. Green and R. G. Cooks, "An Ion Trap with Rectilinear Geometry", 51st ASMS Conference on Mass Spectrometry and Allied Topics, Montreal, Quebec, Canada, Jun 8 - 12 2003, TPJ 184. 23. Z. Takats, Z. Ouyang, B. Gologan, T. Blake, A. J. Guymon, V. J. Davisson and R. G. Cooks, "Protein Microarrays by Ion Soft Landing", 51st ASMS Conference on Mass Spectrometry and Allied Topics, Montreal, Quebec, Canada, June 8 - 12 2003, WPX 460. 24. H. Chen, Z. Ouyang, S. Kothari, X. Fang, Q. Jin, X. Zhang and R. G. Cooks, "A New Sensor-type Mass Spectrometer using a Rectilinear Ion Trap", 52nd ASMS Conference on Mass Spectrometry and Allied Topics, Nashville, Tennessee, May 23 - 27 2004, TPG 134. 25. R. G. Cooks, Z. Ouyang, Z. Takats, B. Gologan, T. M. Blake and V. J. Davisson, "Ion soft land as a preparative method: Protein microarrays generated by mass spectrometry", Abstracts of Papers of the American Chemical Society, Mar 28 2004, 227 U271-U272. 26. R. G. Cooks, L. S. Riter, A. J. Guymon, C. Zhang, G. Wu, H. Chen, Y. Song, Z. Ouyang, M. Blain, D. Austin, D. Cruz and G. E. Patterson, "New Miniature Ion Trap Mass Spectrometers", 52nd ASMS Conference on Mass Spectrometry and Allied Topics, Nashville, Tennesee, May 23 - 27 2004, WOEpm 03:00. 27. Y. Song, Z. Ouyang, G. Wu, W. Plass, H. Chen and R. G. Cooks, "Rectilinear Ion Trap Mass Spectrometer", 52nd ASMS Conference on Mass Spectrometry and Allied Topics, Nashville, Tennessee, May 23 - 27 2004, TPF 108. 28. I. Fedulova, S. Pevstov, M. Zhang, Z. Ouyang, S. Prabhakar and X. Zhang, "InProID: An Integrated Protein Identification System", 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 5 - 9 2005, WP21 - 393. 29. Z. Ouyang, A. M. Tabert, L. Gao, C. D. Fico, G. Wu, Y. Song, H. Chen, C. Zhang, W. Plass, Q. Song, S. Kothari, M. Yu, W. J. Chappell and R. G. Cooks, "Rectilinear Ion Trap Mass Spectrometers", 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 5 - 9 2005, TODam - 10:35. 30. Y. Song, G. Wu, Q. Song, Z. Ouyang and R. G. Cooks, "Four-electrode Rectilinear Ion Trap – Novel Trapping Method for Linear Ion Traps", 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, Jun 5 - 9 2005, ThP13 - 211. 31. G. Wu, M. Yu, W. Plass, Y. Ouyang, W. J. Chappell, R. G. Cooks and Z. Ouyang, "Ion Trajectory Simulation in Electric Fields with Arbitrary Geometries by ITSIM", 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 5 - 9 2005, WP19 - 344. 32. P. Yang, Z. Ouyang, R. G. Cooks, A. M. Hawkridge and D. C. Muddiman, "Soft Protein Ionization Assisted by High Velocity Gas Flow", 53rd Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 5 - 9 2005, 33. C. Zhang, H. Chen, G. Wu, A. J. Guymon, R. G. Cooks and Z. Ouyang, "A Miniature Rectilinear Ion Trap Mass Spectrometer with Fixed RF for Targeted Compound Monitoring", 53rd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 5 -9 2005 MP04 - 046. 34. R. G. Cooks, M. G. Blain, W. J. Chappell, D. Cruz, B. Fabian, M. Fico, A. Guymon, Z. Ouyang, Y. Song, G. Wu and M. Yu, "Miniature and Micro Ion Traps and Arrays", 57th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Orlando, Florida, March 12 - 17 2006, 520 -521. 35. R. G. Cooks, Z. Ouyang, L. Gao, M. Fico and W. J. Chappell, "Quadrupole Ion Traps and Trap Arrays: Geometry, Material, Scale, Performance", 17th International Mass Spectrometry Conference Prague, Czech, Auguest 28- 31 2006, ThOr-01. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 18 of 23

36. I. Fedulova, H. Mirzaei, S. Pevstov, Z. Ouyang and X. Zhang, "PepTiger: Search Engine for Error-Tolerant Protein Identification from de Novo Sequences", 54th ASMS Conference for Mass Spectrometry and Allied Topics, Seattle, Washington, May 28 - June 1 2006, MP15 337. 37. L. Gao, S. Kothari, Z. Ouyang, Q. Song and R. G. Cooks, "Handheld Rectilinear Ion Trap Mass Spectrometer", 57th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Orlando, FL, US, March 12-17 2006, 200-281P. 38. L. Gao, Q. Song, C. D. Fico, Z. Ouyang, G. E. Patterson, B. Knecht, J. L. Springston, A. D. Keil, R. J. Noll and R. G. Cooks, "Handheld Rectilinear Ion Trap Mass Spectrometer", 54th ASMS Conference for Mass Spectrometry and Allied Topics, Seattle, Washington, May 28 - June 1 2006, ThP10 153. 39. Z. Ouyang, W. R. Plass, G. Wu, M. Yu, W. J. Chappell and R. G. Cooks, "3D Ion Trajectory Simulations for Electrode Configurations with Arbitrary Geometries", 17th International Mass Spectrometry Conference, Prague, Czech, August 28-31 2006, TuP-177 40. M. Fico, M. Yu, W. Xu, Z. Ouyang, W. J. Chappell and R. G. Cooks, "Polymer-based Rectilinear Ion Traps", 55th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, Indiana, June 3 - 7 2007, WPE 093. 41. L. Gao, X. Huang, R. S. Milks, J. S. Duncan, B. K. Schoder, R. G. Cooks and Z. Ouyang, "Mini 11 Handheld Mass Spectrometer with an Atmospheric Pressure Interface and a Glow Discharge Source", 55th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, Indiana, June 3 - 7 2007, TPB 037. 42. L. Gao, A. Sugiarto, J. Harper, J. S. Duncan, R. S. Milks, B. KlineSchoder, R. G. Cooks and Z. Ouyang, "Mini 11 Handheld Mass Spectrometer with Glow Discharge Ion Source and Atmospheric Pressure Interface ", The 6th Harsh-Environment Mass Spectrometry Workshop, Cocoa Beach , Florida, September 17-20 2007, Technical Session IV: Instrumentation - Interfaces. 43. H. Hernandez, A. D. Keil, M. Fico, Q. Song, R. J. Noll, Z. Ouyang and R. G. Cooks, "Monitoring of Gaseous Toxic Compounds in Air Using a Handheld Rectilinear Ion Trap Mass Spectrometer", 55th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, Indiana, June 3 - 7 2007, ThPJ 148. 44. A. D. Keil, N. Talaty, H. Hernandez, R. J. Noll, Z. Ouyang and R. G. Cooks, "Atmospheric Pressure Interface for a Handheld Ion Trap Mass Spectrometer: Electrospray Ionization and Desorption Electrospray Ionization", 55th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, Indiana, June 3 - 7 2007, WOFam 08:15. 45. S. A. Smith, T. Blake, D. R. Ifa, R. G. Cooks and Z. Ouyang, "Dual-Source Mass Spectrometer with MALDI- LIT-ESI Configuration", 55th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, Indiana, June 3 - 7 2007, TPB 040. 46. Q. Song, S. A. Smith, Z. Ouyang and R. G. Cooks, "High-Throughput Improvements for Preparative Mass Spectrometry", 55th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, Indiana, June 3 - 7 2007, TPB 030. 47. W. Xu, M. Yu, Z. Ouyang, R. G. Cooks and W. J. Chappell, "Surface Roughness Effects on Dimensionally- Scaled Ion Traps", 55th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, Indiana, June 3 - 7 2007, TPB 032. 48. L. Gao, J. Harper, R. G. Cooks and Z. Ouyang, "Mini 11 handheld mass spectrometer and its applications in biomedical area", 59th Pittsburgh Conference an Analytical Chemistry and Applied Spectroscopy, New Orleans, LA, US, March 1-7 2008, 1150-1155. 49. J. D. Harper, A. C. Nicholas, C. C. Mulligan, X. Zhang, R. G. Cooks and Z. Ouyang, "Low temperature plasma (LTP) probe for ambient desorption ionization", 56th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, US, June 1-5 2008, TOCam 09:10am. 50. T. Kistler, N. Manicke, P. Sinha, q. Kahn, Y. Zhou, R. G. Cooks and Z. Ouyang, "DESI source for imaging and high throughput analysis", 59th Pittsburgh Conference an Analytical Chemistry and Applied Spectroscopy, New Orleans, LA, US, March 1-7 2008, 1250-1222. 51. N. E. Manicke, S. Khandelwal, A. B. Costa, T. Kistler, D. R. Ifa, R. G. Cooks and Z. Ouyang, "Automated Collection and Analysis of Desorption Electrospray Ionization (DESI) Mass Spectrometry Imaging Data", 56th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, US, June 1-5 2008, MPF 118. 52. C. C. Mulligan, S. B. Hooser, J. D. Harper, N. A. Charipar, C. Wilson, Z. Ouyang and R. G. Cooks, "Toxicological Applications of Ambient Mass Spectrometry: Direct Analysis of Biological Matrices", 56th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, US, June 1-5 2008, ThPH 206. 53. Z. Nie, M. Goodwin, W.-P. Peng, M. Volny, Z. Ouyang and R. G. Cooks, "High throughput mass-selective soft landing with rectilinear ion trap in RF/DC isolation mode", 56th ASMS on Mass Spectrometry and Allied Topics, Denver, CO, US, June 1-5 2008, WPAA 031. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 19 of 23

54. Z. Ouyang, N. A. Charipar, J. D. Harper, L. Gao, N. E. Manicke, M. A. Visbal, G. Huang and R. G. Cooks, "Ambient sampling ionization methods and miniature ion trap mass spectrometer for fast and in-situ chemical analysis", Eastern Analytical Symposium, Somerset, NJ, November 17-20 2008, 55. Q. Song, S. A. Smith, M. Volny, Z. Ouyang and R. G. Cooks, "High throughput preparative mass spectrometry with continuous mass selective waveform isolation", 56th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, US, June 1-5 2008, ThPA 007. 56. Y. Xia, Z. Ouyang and R. G. Cooks, "Peptide fragmentation induced by low temperature plasma activated surface", 56th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, June 1-5 2008, WOBam 08:50am. 57. W. Xu, Q. Song, W. Chappell, R. G. Cooks and Z. Ouyang, "Ion trap operation at high pressures", Asilomar Conference on Mass Spectrometry Pacific Grove, CA, October 10-13 2008, 58. W. Xu, Q. Song, J. Maas, M. Fico, L. Gao, W. Chappell, R. G. Cooks and Z. Ouyang, "High pressure and fabrication imperfection effects on performance of miniature ion trap and ion trap array", 56th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, US, June 1-5 2008, WPAA 036. 59. N. A. Charipar, J. D. Harper, M. A. Kirleis, W. Xu and Z. Ouyang, "High Efficiency Mass Spectrometry Systems with Discontinuous Atmospheric Pressure Interface", 57th ASMS Conference on Mass Spectrometry and Allied Topics, Philadelphia, Pennsylvania, May 31 - June 4, 2009 2009, Instrumentation: New Concepts - 319. 60. R. G. Cooks, A. Costa, A. Dill, D. Ifa, N. Manicke and Z. Ouyang, "Ambient Ionization and Imaging Mass Spectrometry: Biomedical Applications", 60th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Chicago, IL, US2009, 620-621. 61. R. G. Cooks, J. Harper, N. Charipar, G. Huang, L. Gao, R. J. Noll and Z. Ouyang, "Miniature Mass Spectrometers: Overview ", 57th ASMS Conference on Mass Spectrometry and Allied Topics, Philadelphia, Pennsylvania, May 31 - June 4, 2009 2009, Miniaturization of the Mass Spectrometer - 2:30 pm. 62. R. G. Cooks, D. Ifa, A. Dill, N. Manicke, A. Costa and Z. Ouyang, "Ambient Ionization and Imaging Mass Spectrometry: Biomedical Applications ", PITTCON 2009, Chicago, March 8-13, 2009 2009, 63. L. Gao, J. Harper, G. Huang, S. Kothari, N. Sanders, R. G. Cooks and Z. Ouyang, "Development, Characterization and Optimization of a Multiple Source Rectilinear Ion Trap Miniature Mass Spectrometers", 57th ASMS Conference on Mass Spectrometry and Allied Topics, Philadelphia, Pennsylvania, May 31 - June 4, 2009 2009, Miniaturization of the Mass Spectrometer - 4:10 pm. 64. G. Huang, Z. Ouyang and R. G. Cooks, "Melamine Screening in Milk using Low Temperature Plasma Ionization on a Portable Mass Spectrometer", 57th ASMS Conference on Mass Spectrometry and Allied Topics, Philadelphia, Pennsylvania, May 31 - June 4, 2009 2009, Environmental II - 588. 65. J. Maas, S. Smith, Z. Ouyang, R. G. Cooks and W. Chappell, "Miniature Monolithic Rectilinear Ion Traps and Arrays by Stereo-lithography on Printed Circuit Board (SLA-on-PCB)", 57th ASMS Conference on Mass Spectrometry and Allied Topics, Philadelphia, Pennsylvania, May 31 - June 4, 2009 2009, Developments in Ion Trapping Instumentation - 3:30 pm. 66. J. S. Wiley, J. F. Garcia-Reyes, J. Harper, N. Charipar, Z. Ouyang and R. G. Cooks, "Screening of Agrochemicals in Foodstuffs and Water using Low Temperature Plasma (LTP) Ambient Mass Spectrometry", 57th ASMS Conference on Mass Spectrometry and Allied Topics, Philadelphia, Pennsylvania, May 31 - June 4, 2009 2009, Agriculture - 550. 67. Y. Xia, H. Wang, M. Pazzi, Z. Ouyang and R. G. Cooks, "Fragmentation of Peptide Ions during Electrospray Ionization", 57th ASMS Conference on Mass Spectrometry and Allied Topics, Philadelphia, Pennsylvania, May 31 - June 4, 2009 2009, Peptides Fragmentation and Sequencing - 359. 68. R. G. Cooks, Z. Ouyang and F. K. Tadjimukhamedov, "Handheld Mass Spectrometers ", PITTCON 2010, Orlando, Florida, February 28- March 5, 2010 2010, 69. J. F. Garcia-Reyes, J. Harper, N. Charipar, A. Jackson, M. B. Neto, Z. Ouyang and R. G. Cooks, "Desorption/Ionization capabilities of ambient low-temperature plasma (LTP) mass spectrometry for small molecule applications ", 58th ASMS Conference on Mass Spectrometry and Allied Topics, Salt Lake City, Utah, May 23 - 27, 2010 2010, MP27. 70. S. Garimella, J. Harper, G. Huang, W. Xu, R. G. Cooks and Z. Ouyang, "Laminar Flow Assisted Ion Transfer for Mass Analysis", 58th ASMS Conference on Mass Spectrometry and Allied Topics, Salt Lake City, Utah, May 23 - 27, 2010 2010, WP31. 71. P. Hendricks, J. Maas, W. Chappell, Z. Ouyang and R. G. Cooks, "Reduced Scale Rectilinear Ion Trap Arrays", 58th ASMS Conference on Mass Spectrometry and Allied Topics, Salt Lake City, Utah, May 23 - 27, 2010 2010, ThP28. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 20 of 23

72. K. Hou, W. Xu, J. Xu, T.-C. Chen, R. G. Cooks and Z. Ouyang, "Development of a Backpack Mass Spectrometer with an Extended Probe", 58th ASMS Conference on Mass Spectrometry and Allied Topics, Salt Lake City, Utah, May 23 - 27, 2010 2010, ThP28. 73. G. Huang, M. A. Visbal-Onufrak, J. Harper, Y. Zhou, R. G. Cooks and Z. Ouyang, "Compact Design of Handheld Mass Spectrometer Equipped with Ambient Ionization Source for In Situ Analysis", 58th ASMS Conference on Mass Spectrometry and Allied Topics, Salt Lake City, Utah, May 23 - 27, 2010 2010, TP24. 74. M. A. Kirleis, W. Xu, R. G. Cooks and Z. Ouyang, "Tutorial: Prototyping Architectures for Ion Trap Mass Spectrometers ", 58th ASMS Conference on Mass Spectrometry and Allied Topics, Salt Lake City, Utah, May 23 - 27, 2010 2010, ThP28. 75. N. Manicke, H. Wang, Z. Ouyang and R. G. Cooks, "Paper Spray for Ambient Analysis of Complex Mixtures using Mass Spectrometry", 58th ASMS Conference on Mass Spectrometry and Allied Topics, Salt Lake City, Utah, May 23 - 27, 2010 2010, MP26. 76. B. Prentice, W. Xu, Z. Ouyang and S. A. Mcluckey, "DC Potentials Applied to Endcap Electrodes of 3-D Ion Traps for Increased Ion Injection Efficiency and Manipulation of Ion/Ion Reactions", 58th ASMS Conference on Mass Spectrometry and Allied Topics, Salt Lake City, Utah, May 23 - 27, 2010 2010, MOB am. 77. F. K. Tadjimukhamedov, R. G. Cooks, Z. Ouyang and A. Jackson, "Coupling Differential Mobility Spectrometer to Miniature Mass Spectrometer", PITTCON 2010, Orlando, Florida, February 28- March 5, 2010 2010, 78. H. Wang, "Fragmentation of Peptide Ions during Nanoelectrospray Ionization", ASMS Asilomar Conference on Mass Spectrometry, Pacific Grove, CA, October 8 - 12, 201 2010, 79. H. Wang, N. Manicke, R. G. Cooks and Z. Ouyang, "Paper Spray Mass Spectrometry for Ambient Analysis of Tissue Samples", 58th ASMS Conference on Mass Spectrometry and Allied Topics, Salt Lake City, Utah, May 23 - 27, 2010 2010, TP24. 80. W. Xu, M. Kirleis, N. Charipar, Y. Xia, W. Chappell and Z. Ouyang, "Discontinuous Atmospheric Pressure Interface for Mass Spectrometry Instrumentation: Theory, development and Application", 58th ASMS Conference on Mass Spectrometry and Allied Topics, Salt Lake City, Utah, May 23 - 27, 2010 2010, ThOD pm. 81. Q. Yang, "Development and Application of Paper Spray Ionization", ASMS Asilomar Conference on Mass Spectrometry, Pacific Grove, CA October 8 - 12, 2010 2010, 82. Q. Yang, H. Wang, J. Maas, N. Manicke, R. G. Cooks and Z. Ouyang, "Development of Microfluidic Paper Spray Devices for Ambient Chemical Analysis Using Mass Spectrometry", 58th ASMS Conference on Mass Spectrometry and Allied Topics, Salt Lake City, Utah, May 23 - 27, 2010 2010, MP28. 83. C.-H. Chen, Z. Lin, S. Garimella, R. G. Cooks and Z. Ouyang, "Development of an endoscopic DESI sampling probe", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9, 2011 2011, TP02-034. 84. T.-C. Chen, S. Garimella, W. Xu and Z. Ouyang, "Ion Introduction through Discontinuous Atmospheric Pressure Interface with Bent Pathway", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9, 2011 2011, ThP02-036. 85. P. Hendricks, J. Maas, F. Boudreau, F. Tadjimukhamedov, W. Chappell, R. J. Noll, Z. Ouyang and R. G. Cooks, "Comparison of Rectilinear Ion Traps and Ion Trap Arrays", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9, 2011 2011, ThP04-073. 86. G. Huang, G. Li, J. S. Ducan, Z. Ouyang and R. G. Cooks, "Synchronized Inductive Desorption Electrospray Ionization Mass Spectrometry", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9 2011, ThOG 02:50. 87. A. Li, H. Wang, M. Wleklinski, R. Espy, Z. Ouyang and R. G. Cooks, "Paper spray ionization using solvents of low polarity or high viscosity", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9, 2011 2011, TP01-019. 88. G. Li, X. Li, Z. Ouyang and R. G. Cooks, "Activation of C-C and C-H bonds in Hydrocarbons by Field-Assisted Nitrogen Atom Insertion", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9, 2011 2011, TP01-018. 89. X. Li, G. Li, Z. Ouyang and G. Cooks, "Atmospheric Pressure Field Desorption of Alkanes from Paper", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9, 2011 2011, TP13-283. 90. J. Liu, H. Wang, R. G. Cooks and Z. Ouyang, "Leaf Spray: Direct Ambient Ionization for Plant Tissue Analysis", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9, 2011 2011, TP02-035. 91. S. Oradu, D. R. Ifa, Z. Ouyang, R. G. Cooks, B. Kraeutler2 and T. Mueller, "Plant Imprint Imaging Using Desorption Electrospray Ionization Mass Spectrometry (DESI-MS)", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9, 2011 2011, ThP23-424. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 21 of 23

92. H. Wang, N. Manicke, Q. Yang, L. Zheng, R. Shi, R. G. Cooks and Z. Ouyang, "Direct Analysis of Biological Tissue by Paper Spray Mass Spectrometry", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9, 2011 2011, MP02-048. 93. X. Xiong, X. Fang, Y. Jiang, Z. Huang, Y. Zhang and Z. Ouyang, "Development of a Data Processing and Analysis Software for Mass Spectrometry Imaging", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9, 2011 2011, TP19-205. 94. Q. Yang, N. Manicke, C. Petucci, R. G. Cooks and Z. Ouyang, "Direct and Quantitative Analysis of Acylcarnitines in Serum and Whole Blood Using Paper Spray Mass Spectrometry", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9, 2011 2011, MP02-046. 95. Z. Zhang, N. Manicke, W. Xu, R. G. Cooks and Z. Ouyang, "Direct Analysis of Therapeutic Drugs in Dried Blood Spots using Paper Spray and a Miniature Mass Spectrometer", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9, 2011 2011, MP02-047. 96. T.-C. Chen, J. Dalgleish, L. Li, M. Kirleis, J. Duncan, M. McNicholas, J. Denton, J. Shelley, P. Hendricks, C.-H. Chen, R. G. Cooks and Z. Ouyang, "Backpack Mass Spectrometer with Hand-Held Sampling Probe for In-Field Analysis –Instrument Architecture and Characterization", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, WP 696. 97. R. G. Cooks, Z. Ouyang, R. D. Espy, A. Badu-Tawiah and T. Mueller, "The Chemistry in the Splash: Fundamentals of Desorption Electrospray Ionization", The Pittsburgh Conference on Analytical, Chemistry and Applied Spectroscopy, Orlando, FL, March 11-15 2012, 98. J. Dalgleish, M. Wleklinski, J. Shelley, C. Mulligan, Z. Ouyang and R. G. Cooks, "Development and Characterization of Bundled Arrays of low-temperature Plasma Probes for use as Improved Ambient Ionization Sources", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, MP 681. 99. Y. Du, W. Xu and Z. Ouyang, "Self-Correlation Method for Processing Random Phase Signals in Fourier Transform Mass Spectrometry", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, WP 697. 100. R. Espy, A. Muliadi, Z. Ouyang and R. G. Cooks, "Spray Mechanism in Paper Spray Ionization Mass Spectrometry", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20- 24 2012, WP 711. 101. M. Furlong, Z. Ouyang, S. T. Wu, J. Tamura, R. Ramanathan, T. Olah, A. Tymiak and M. Jemal, "A universal Surrogate Tryptic Peptide for LC-MS/MS Bioanalysis of Human Monoclonal Antibody and Fc-fusion Proteins in Animal Pharmacokinetic Study", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, MOE pm 2:50. 102. G. Li, X. Li, Z. Ouyang and R. G. Cooks, "Hydrocarbon Analysis by Field-Assisted Paper Spray", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, ThP 498. 103. L. Li, W. Xu and Z. Ouyang, "Performance Optimization of Ion Sponge", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, MP 691. 104. J. Liu, R. G. Cooks and Z. Ouyang, "Biological Tissue Analysis Using Needle Biopsy and Direct Spray Ionization Mass Spectrometry", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, TP 723. 105. Z. Ouyang, R. G. Cooks, H. Hertig, T.-C. Chen, N. Manicke, L. Li, C.-H. Chen and J. Liu, "Proof-of-Concept Development of a Personal Mass Spectrometer", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, WP 695. 106. L. Shen, J. Zhang, Q. Yang, N. Manicke and Z. Ouyang, "High Throughput Paper Spray Mass Spectrometry Analysis of Therapeutic Drugs in Dried Blood Spots", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, ThP 361. 107. H. Wang, R. G. Cooks and Z. Ouyang, "Multi-Mode Ionization during Paper Spray and Its Applications to Chemical Analysis", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, WP 712. 108. X. Xiong, X. Fang, Y. Deng, Z. Ouyang and W. Xu, "Accelerated Simulation Study of Space Charge Effects in Quadrupole Ion Trap Usings GPU Techniques", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, WP 694. 109. Q. Yang, H. Wang, R. G. Cooks and Z. Ouyang, "Fast Screening of Amino Acids Disorders Using Paper Spray Mass Spectrometry", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, ThP 43. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 22 of 23

110. Z. Zhang, R. G. Cooks and Z. Ouyang, "Rapid Determination of Illicit Additives in Foodstuff using Paper Spray", 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, May 20-24 2012, ThOA am 10:10. 111. T.-C. Chen, C.-H. Chen, R. G. Cooks, R. Kline-Schoder, P. Sorensen and Z. Ouyang, "Design of Portable Mass Spectrometers with Handheld Probes: An Aspect of Ion Introduction and Pumping System", 61st ASMS Conference on Mass Spectrometry and Allied Topics, Minneapolis, MN, June 9-13 2013, TP 091. 112. R. G. Cooks and Z. Ouyang, in The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Philadelphia, PA, Editon edn., 2013. 113. R. G. Cooks, Z. Ouyang, R. Augusti, J. Jiu, Z. Zhiping, P. Wei and J. Wiley, in The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Philadelphia, PA, Editon edn., 2013. 114. Y. M. Du, C. Konda, Y. Xia and Z. Ouyang, "Statistical Analysis Model for Classifying Stereo Structures of Oligosaccharides", 61st ASMS Conference on Mass Spectrometry and Allied Topics, Minneapolis, MN, June 9- 13 2013, ThP 373. 115. P. I. Hendricks, J. T. Shelley, J. K. Dalgleish, J. S. Duncan, M. T. McNicholas, L. Li, T.-C. Chen, Z. Ouyang and R. G. Cooks, "A Miniature Mass Spectrometer for in-situ and Realtime Chemical Analysis", 61st ASMS Conference on Mass Spectrometry and Allied Topics, Minneapolis, MN, June 9-13 2013, MP 331. 116. A. Li, P. Wei, H.-C. Hsu, L. Li, Z. Ouyang and R. G. Cooks, "Direct Analysis of 4-Methylimidazole in Foods using Paper Spray Mass Spectrometry", 61st ASMS Conference on Mass Spectrometry and Allied Topics, Minneapolis, MN, June 9-13 2013, TP 745. 117. L. Li, Y. Ren, T.-C. Chen, Z. Lin, R. G. Cooks and Z. Ouyang, "Development and Performance Characterization of a Personal Mass Spectrometry System", 61st ASMS Conference on Mass Spectrometry and Allied Topics, Minneapolis, MN, June 9-13 2013, MP 330. 118. J. Liu, R. G. Cooks and Z. Ouyang, "Internal Standard Coated Capillary Dispenser for Quantitative Ambient Ionization Mass Spectrometry", 61st ASMS Conference on Mass Spectrometry and Allied Topics, Minneapolis, MN, June 9-13 2013, ThP 627. 119. J. Liu, P. Wei, J. Wiley, A. Jackson, P. Sanghani, J. Gilbert, B. McNew, Z. Ouyang and R. G. Cooks, "Quantitative Analysis of Triglycerides and Fatty Acid Profiling in Oils and Oil Seeds Using Ambient Mass Spectrometry", 61st ASMS Conference on Mass Spectrometry and Allied Topics, Minneapolis, MN, June 9-13 2013, TP 689. 120. Y. Ren, J. Liu, L. Li, M. N. McLuckey and Z. Ouyang, "Quantitative Ambient Analysis Using Simple Extraction Spray", 61st ASMS Conference on Mass Spectrometry and Allied Topics, Minneapolis, MN, June 9-13 2013, TP 080. 121. Y. Su, J. Liu, R. G. Cooks and Z. Ouyang, "Improvement of Quantitative Performance of Paper Spray Mass Spectrometry by oxidative Treatment Of Paper Substrates", 61st ASMS Conference on Mass Spectrometry and Allied Topics, Minneapolis, MN, June 9-13 2013, TP 688. 122. X. Wang, T.-C. Chen and Z. Ouyang, "Direct Detection of Nonvolatile Compounds Using Synchronized Discharge Ionization with Handheld Mass Spectrometer", 61st ASMS Conference on Mass Spectrometry and Allied Topics, Minneapolis, MN, June 9-13 2013, TP 079. 123. P. Wei, J. S. Wiley, J. Liu, C. Pulliam, A. U. Jackson, H. Tank, J. R. Gilbert, J. Gifford, K. Yau, J. Whitteck, Z. Ouyang and R. G. Cooks, in 61st ASMS Conference on Mass Spectrometry and Allied Topics, Minneapolis, MN, Editon edn., 2013, p. TP 686. 124. X. Zhou and Z. Ouyang, "Electro-Hydrodynamic Simulations for Mass Spectrometers in Transitional Flow Regime", 61st ASMS Conference on Mass Spectrometry and Allied Topics, Minneapolis, MN, June 9-13 2013, ThP 078. 125. R. E. ROBERT G. COOKS, Pu Wei, Christopher J Pulliam, Zheng Ouyang, "Ambient Ionization and Miniature Mass Spectrometers in Forensic Science", The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Chicago, IL, March 2-6 2014, 80-2 126. Z. O. Xiaoyu Zhou, "Simulation of Ion Trajectories through An Entire Mass Spectrometer - Incorporation of a Full Gas Dynamic Field with Electric Field", 62nd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, MD, June 15-19 2014, THP 760. 127. R. G. C. Y. Melodie Du, Yu Xia, Ye Hu, Zheng Ouyang, "An Informatics Approach for Evaluating and Guiding Method Development for Biomarker", 62nd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, MD, June 15-19 2014, WP 21. 128. X. M. Yuan Su, Yu Xia, Zheng Ouyang, "Direct Profiling of Unsaturated Lipids in Tissue Using Extraction Spray Mass Spectrometry with Paternò-Büchi Reaction", 62nd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, MD, June 15-19 2014, WP 388. Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 23 of 23

129. M. M. Yue Ren, Jiangjiang Liu, Zheng Ouyang, "Slug Flow Microextraction NanoESI with Real-Time Derivatization for Rapid Analysis of Biofluid Sample", 62nd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, MD, June 15-19 2014, WP 747. 130. L. T. Ziqing Lin, Yang Yang, Mingji Dai, Frantisek Tureuek, Zheng Ouyang, Yu Xia, "Reactions of Biomolecule Ions with Pyrolysis-formed Carbene", 62nd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, MD, June 15-19 2014, TP 353. 131. L. T. Ziqing Lin, Yu Xia, Zheng Ouyang, "Instrumentation and Studies for Gas-phase Ion/Radical Reactions", 2014 Sanibel conference, Clearwater Beach, Florida, Jan. 30 - Feb. 2 2014, Jan 31. #19.

Department of Chemistry and Biochemistry Vicki Wysocki, Ph.D. Professor Ohio Eminent Scholar 279 Biomedical Research Tower Columbus, OH 43210 [email protected] April 24, 2019 Phone: 614-292-8687

SSP Spectroscopy Award Committee

2019 Pittsburgh Spectroscopy Award Chairman c/o Spectroscopy Society of Pittsburgh 300 Penn Center Blvd., Suite 332 Pittsburgh, PA 15235-5503

Dear Selection Committee:

I am delighted to support the nomination of Professor Zheng Ouyang for The Pittsburgh Spectroscopy Award. I can think of no other candidate who is such an outstanding match to this award – for outstanding contributions in the field of applied spectroscopy. Dr. Ouyang’s interest in applied work is evident from early in his career when he obtained engineering bachelor’s and master’s degrees in Automation Control. He expanded from there to Master’s, PhD, and postdoc work in Analytical Chemistry at Purdue, a premier university for analytical chemistry instrument development research. Dr. Ouyang’s many achievements are evident in the documentation provided with the award nomination. He has not only published a large number of papers but they are highly cited, resulting in an h index that is likely the envy of many senior colleagues. He not only has a large numbers of patents (55) but those inventions have been turned into technology/devices that benefit the public. Despite his surely hectic research and development schedule, including an academic position and running a company, Dr. Ouyang still makes time to interact with and lead the analytical community (e.g., editorial boards and editorships, session organization at Pittcon, co- organization of US-China Analytical Chemistry workshops). Dr. Ouyang also cares about development of young students and faculty as indicated by his request to meet with me to discuss the career path of one of my PhD graduates who was vacillating about whether to take a faculty job in the US or China. Dr. Ouyang really cared that this young scientist make the right choice for his future career.

Many years ago when I was interviewing for an academic position, a faculty member criticized me for not proposing to build the biggest, most expensive mass spectrometer that I could think of. I replied that while there is some value in those unique ultra-expensive instruments that make one-of-a-kind measurements, a just-as-important or more important contribution may be from those who make less expensive instruments accessible to applications that benefit humans daily in multiple ways. Zheng Ouyang’s many significant contributions are important because they make measurements accessible to real-world applications. Please reward his amazing applied mass spectrometry contributions with the Pittsburgh Spectroscopy Award.

Sincerely,

Vicki Wysocki, Ph.D. Professor and Ohio Eminent Scholar Director, Campus Chemical Instrumentation Center