Department of Chemistry R. Graham Cooks Henry Bohn Hass Distinguished Professor April 26, 2019 SSP Spectroscopy Award Committee 2019 Pittsburgh Spectroscopy Award Chairman c/o Spectroscopy society of Pittsburgh 300 Penn Center Blvd., Suite 332 Pittsburgh, PA 15235-5503 RE: Zheng Ouyang Pitt Spec Award Dear Selection Committee: Zheng Ouyang has been a key figure in a series of dramatic advances in what might be called ‘real world’ mass spectrometry. This involves analysis of often complex samples for small molecule drugs, and for compounds of concern for environmental, food safety, and forensic reasons. This ‘blue collar’ area of science has not received the attention accorded to methods that break resolution records or perform other exotic feats. What it does however, is address real societal issues by performing analytical measurements in a cost effective fashion. The examples of this type of measurement range from fentanyls in blood to Sudan dyes in food, from drug metabolites in serum to phospholipid biomarkers in tissue. The solutions that Ouyang has championed combine two elements: ambient ionization for speed and simplicity and portable mass spectrometers for on-site analysis. The ambient ionization method that Ouyang invented is paper spray ionization, commercialized as OmniSpray ® by Prosolia and very recently as PaperSpray ® by Thermo. This method is simple, fast, and quantitative, and particularly well-suited to drugs in biofluids and forensics analyses. The method has been cited some 750 times. There are, according to the Web of Science, 4 highly cited papers on this topic since it was invented in 2010 , and each is authored by Ouyang. Ambient ionization methods are ideally suited to in situ use with portable mass spectrometers. Here too, Zheng Ouyang has made enormous contributions, in leading a Purdue team that developed the Mini 11 and 12 versions of ion trap MS/MS capable instruments. Substantial improvements in ion introduction, vacuum systems, and ion trap operation are included in these compact instruments and a substantial patent portfolio underlies this academic lab effort. Subsequently, Ouyang has established (in both the US and China) a company, PurSpec which is marketing these instruments. Marketing a technology is a necessary aspect of providing a technology to the public and this was Prof. Ouyang’s motivation. Prof Ouyang has served the national analytical chemistry community through his inventions, publications, role in journals and through the series of symposia at Pittcon on Miniature Mass Spectrometers. These have been held for eight years and a ninth is planned. The symposium in 2018 was selected as the Waters Symposium. The strength of his scholarship is evident from the 13,000 times his 160 papers have been cited (h index 63). Perhaps even more notable is the commercialization of his paper spray technology by Prosolia and recently Waters, his 55 US patents and his role as CEO and founder of PurSpec Technologies, a mini mass spectrometry company. Dr Ouyang’s work has been 560 Oval Drive ▲ West Lafayette, IN 47907-2084 ▲ (765) 494-5263 ▲ (765) 494-9421 ▲ [email protected] funded by NASA (the ExoMars mission is using his discontinuous atmospheric pressure interface), by several NIH R01 grants, and by NSF (Early Career Award). Zheng Ouyang is certainly the most inventive person I have ever worked with. He is brilliant, highly creative, and a good colleague. I believe him to be extremely highly deserving of this honor, which will bring appropriate credit to him and encourage the international exchange of information, which underlies all of science. Sincerely, R. Graham Cooks DEPARTMENT OF CHEMISTRY, 560 Oval Drive WEST LAFAYETTE, IN 47907-2084 • (765) 494-5263 • FAX: (765) 494-9421 • E-MAIL: [email protected] Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 1 of 23 ZHENG OUYANG Professor Department of Precision Instrument, Tsinghua University, Beijing 100084, China Email: [email protected] Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA Email: [email protected] EDUCATION&TRAINING B.E. Automatic Control, Tsinghua University, Beijing, China, July 1993. M.E. Automatic Control Theory and Its Application, Tsinghua University, Beijing, China, July 1995. M.S. Physical Chemistry, West Virginia University, Morgantown, WV, May 1997. Ph. D. Analytical Chemistry, Purdue University, West Lafayette, IN, May 2002 Postdoc Analytical Chemistry, Purdue University, West Lafayette, IN, February 2002 - February 24, 2003 POSITIONS 2003 – 2005 Assistant Research Scientist, Department of Chemistry, Purdue University 2006 – 2007 Associate Research Scientist, Department of Chemistry, Purdue University 2006 – 2008 Guest Professor, Institute of Metrology of China 2007 – 2012 Assistant Professor, Weldon School of Biomedical Engineering, Purdue University 2012 – 2015 Associate Professor, Weldon School of Biomedical Engineering, Purdue University 2008 – 2016 Assistant/Associate/Full Professor (courtesy), Department of Electrical and Computer Engineering, Purdue University 2014 – 2016 Associate/Full Professor (courtesy), Department of Chemistry, Purdue University 2015 – 2016 Professor, Weldon School of Biomedical Engineering, Purdue University 2015 – 2016 Professor (courtesy), Department of Precision Instrument, Tsinghua University 2016 – present Professor (adjunct), Weldon School of Biomedical Engineering, Purdue University 2017 – present Professor, Department of Precision Instrument, Tsinghua University 2017 – present Chairman, Department of Precision Instrument, Tsinghua University 2017 – present Deputy Dean, School of Mechanical Engineering, Tsinghua University PROFESSIONAL AFFILIATION American Chemical Society American Society for Mass Spectrometry American Institute for Medical and Biological Engineering (Fellow) ENTREPRENEURIAL ACTIVITIES Founder of PURSPEC Technologies, Inc. Founding Director of Shanghai Institute for Analytical Technology AWARDS AND HONORS 1999-2002 Phillips Petroleum Fellowship, 1999-2002 2007 China National Natural Science Foundation Award for Distinguished Oversea Young Scholars 2008 Wallace H. Coulter Foundation Early Career Translational Research Award in Biomedical Engineering 2009 National Science Foundation Early Career Award 2009 American Society for Mass Spectrometry Research Award 2010 China National Science and Technology Advancement Award (2nd Class) 2012 International Mass Spectrometry Foundation, Curt Brunnée Award for outstanding contributions to the development of instrumentation for mass spectrometry 2013 Purdue University College of Engineering Early Career Research Award 2014 Purdue University Faculty Scholar 2016 Fellow of American Institute for Medical and Biological Engineering EDITORIAL BOARD Curriculum Vita, Zheng Ouyang, 4/22/2019 Page 2 of 23 Co-Editor, International Journal of Mass Spectrometry, 2016 – present Associate Editor, Encyclopedia of Analytical Chemistry, 2016 - present Editorial Board, Journal of The American Society for Mass Spectrometry, 2015 – present Guest Editor, Analyst, Themed Issue “Ambient Mass Spectrometry”, 2010 Guest Editor, Analytical Method, Themed Issue “Portable Instrumentation & Point Of Care Technologies”, 2016 CONFERENCE ORGNIZING/WORKSHOP PARTICIPATION Co-chair, “Miniature Mass Spectrometers” session, Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, 2011-1019 Lecturer, American Society for Mass Spectrometry, 2006 Fall Workshop “The Present & Future of Quadrupole Ion Trap Mass Spectrometry” – “Miniature Mass Spectrometry” , San Diego, CA, November 9-10, 2006. Organizer and co-chair, Midwestern Universities Analytical Chemistry Conference, 2010 Co-organizer, 1st US-China Analytical Chemistry Workshop, West Lafayette, IN, USA, 2011 Co-organizer, 2nd US-China Analytical Chemistry Workshop, Beijing, China, 2012 Lecturer, International Mass Spectrometry Conference 2014, Short Course, “Ambient Ionization”, Geneva, Switzerland, August 24-29, 2014 Co-chair, American Society for Mass Spectrometry Asilomar Conference on Mass Spectrometry, 2016 Vice chair, Gordon Research Conference “Molecular Structure Elucidation”, 2016 Co-Chair, Gordon Research Conference “Molecular Structure Elucidation”, 2018 PATENTS 1. Cooks, R. G.; Badman, E. R.; Ouyang, Z.; Wells, J. M. Ion trap array mass spectrometer. US 6762406, 2004. 2. Ouyang, Z.; Cooks, R. G. Rectilinear ion trap and mass analyzer system and method. US 6838666, 2005. 3. Gologan, B.; Takats, Z.; Ouyang, Z.; Cooks, R. System and method for landing of ions on a gas/liquid interface. US 11228946, 2006. 4. Ouyang, Z.; Cooks, R. G. Multiplexed mass spectrometer. US 7157699, 2007. 5. Blake, T.; Ouyang, Z.; Cooks, R. G. System and method for preparative mass spectrometry. US 7381373, 2008. 6. Cooks, R. G.; Ouyang, Z. System and method for the preparation of arrays of biological or other molecules. US 7361311, 2008. 7. Cooks, R. G.; Ouyang, Z.; Song, Y.; Wu, G. Linear Ion Trap with Four Planar Electrodes. US 11814334, 2009. 8. Cooks, R. G.; Peng, W.-P.; Ouyang, Z.; Goodwin, M. P. Methods and apparatuses for preparing a surface to have catalytic activity. US 7910377, 2011. 9. Ouyang, Z.; Gao, L.; Cooks, R. G. Discontinuous atmospheric pressure interface. US 8304718, 2012. 10. Charipar, N.; Harper, J.; Ouyang, Z.; Cooks, R. G. Low temperature plasma probe and methods of use thereof. US 8519354, 2013. 11. Ouyang, Z.; Cooks, R. G.; Garimella, S. V.; Harper, J. D.; Charipar, N. A. Systems and methods for transfer of ions for analysis.