Received: 5 December 2020 Accepted: 9 March 2021 DOI: 10.1002/tpg2.20098 The Plant Genome INVITED REVIEW Systems biology for crop improvement Lekha T. Pazhamala1,* Himabindu Kudapa1,* Wolfram Weckwerth2,3 A. Harvey Millar4 Rajeev K. Varshney1,5 1 Center of Excellence in Genomics & Systems Biology, International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Patancheru, Hyderabad 502 324, India 2 Department of Ecogenomics and Systems Biology, University of Vienna, Vienna, Austria 3 Vienna Metabolomics Center, University of Vienna, Vienna, Austria 4 ARC Centre of Excellence in Plant Energy Biology and School of Molecular Sciences, The University of Western Australia, Perth, WA, Australia 5 State Agricultural Biotechnology Centre, Crop Research Innovation Centre, Food Futures Institute, Murdoch University, Murdoch, WA, Australia Correspondence Rajeev K Varshney, Center of Excellence in Abstract Genomics & Systems Biology, ICRISAT, In recent years, generation of large-scale data from genome, transcriptome, proteome, Patancheru- 502 324, Hyderabad, India Email:
[email protected], metabolome, epigenome, and others, has become routine in several plant species.
[email protected] Most of these datasets in different crop species, however, were studied independently and as a result, full insight could not be gained on the molecular basis of complex *Both authors contributed equally: Lekha T Pazhamala and Himabindu Kudapa traits and biological networks. A systems biology approach involving integration of Assigned to