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ICTALS2019 the Epilepsy Journey ICTALS2019 The Epilepsy Journey 2-5 September In partnership with Abstract book This conference is supported by a grant from the American Epilepsy Society ICTALS2019 The Epilepsy Journey Foreword The International Conference for Technology and Analysis of Seizures, 2019 (ICTALS2019) aims to bring together neurologists, neuroscientists, researchers from quantitative disciplines and people with lived experience of epilepsy in order to work as a community to advance our understanding of epilepsy and develop practical ways to improve diagnosis and treatment. The theme for this year’s conference is: The Epilepsy Journey: from first seizure to treatment and beyond. We will emphasise how advances in our understanding of the dynamics of brain networks can be used to make a difference to people with epilepsy at all points of their journey: from elucidating the causes of the first seizure to diagnosing epilepsy, understanding how ictogenic networks give rise to recurrent seizures and how this insight can inform personalised treatment. To encourage this focus on the whole epilepsy journey we seek to include all relevant communities. In addition to discussions on current scientific, clinical and technological advances, we will take steps to increase accessibility for people with lived experience of epilepsy. Dates: Monday 2 September 2019 - Thursday 5 September 2019 Venue: University of Exeter, Streatham Campus, Xfi Building Conference website: http://ex.ac.uk/ictals2019 Contact the organisers: [email protected] ICTALS2019 The Epilepsy Journey Partners We are partnering with charities Epilepsy Research UK and Epilepsy Action and Alliance for Epilepsy Research. Sponsors This event would not be possible without the generous contributions from our generous sponsors UCB, the Epilepsy Foundation, NeuraLynx, and Liva Nova. This conference is supported by a grant from the American Epilepsy Society Table of Contents This abstract book contains: • Wifi information • Programme • Venue • Conference dinner • Social event • Map of Xfi building • The Network Debates • Not only for scientists • Education Day • Public Speakers • Plenary Speakers • Plenary Talk Abstracts • Contributed Talk Abstracts • Poster Abstracts Wifi information To connect to the free Wifi 1. Ensure wifi is enabled on your device 2. Search the available wireless networks and select UoE_Guest 3. You will be asked to provide the following details: Your name and email address 4. Please tick the terms of use box 5. Click register, you will receive a confirmation receipt Program Monday 2nd Sept Tuesday 3rd Sept Wednesday 4th Sept Thursday 5th Sept Education Epileptogenesis and ictogenesis Ictogenisis and Treatment Ictogenisis and Treatment 8:30 – 9:30 Prof. Mark Richardson 8:30 – 9:30 Profs. Paddy Ssentongo and ICTALS 2019 will take place at the XFi Brain network trait and dynamic states in 8:30 – 9:30 Prof. Kathryn Davis Bruce Gluckman building, University of Exeter. Refreshments genetic generalized epilepsy and My Localizing seizure “hotspots” with From cerebral malaria to epilepsy in human will be served in the Atrium. Talks will be Seizure Gauge: a new multicentre project quantitative neuroimaging held in the Henderson lecture theatre. and in animal models. Posters will be located in the conference rooms. The Epilepsy Action coffee and chat 9:30 – 10:30 Prof. Mark Cook 9.30 - 10.30 Contributed talks: 9.30 - 11.00 Contributed talks: space will be located in the seminar room. Slave To The Rhythm - Cycles and memory Dr. Thorsten Rings Drs. Miao Cao and Daniel Galvis in epilepsy (with apologies to Grace Jones) Dr. Dean Freestone Dr. Gerold Baier 10:30 – 11:00 Refreshments 10:30 – 11:00 Refreshments Dr. John Bernabei 11:00 – 11:30 Refreshments 11:30 – 12:45 Arrival 11:00 – 12:30 Discussion session: 11:00 – 12:30 Discussion session: 11:30 - 12:30 Prof. Cathy Schevon Lunch and registration What are ictogenic networks? Evolving networks: resilliance and control Epilepsy networks across spatial scales 12:45 - 13:00 Welcome 12:30 – 13:30 Lunch 12:30 – 13:30 Lunch 12:30 – 14:00 Lunch 13:00 – 14:00 Prof. Khalid Hamandi Poster Session Poster Session Poster Session Clinical pathways for epilepsy 13:30 – 14:30 Prof. Fabrice Wendling 13:30 – 14:30 Prof. Viktor Jirsa What can micro- and macro-scale Translational Neuroscience: from 14:00 – 14:30 Refreshments computational models reveal about 14:00 – 15:00 Contributed talks: bifurcations to personalized medicine epileptogenesis and ictogenesis? Dr. Rasesh Joshi Dr. Gabrielle Schroeder 14:30 – 16:00 Tutorial: Network methods for 14.30 - 15.30 Contributed talks: understanding epilepsy Dr. Beth Lopour Dr. Piotr Slowinski Dr. Maxime Baud 15:00 – 15:30 Refreshments Dr. Jen Creaser 15:30 – 16:30 Contributed talks: 16:00 – 16:30 Refreshments 15:30 – 16:00 Refreshments Prof. Bill Stacey Prof. Premysl Jiruska 16:30 – 18:30 Testimony from people with 16.30 Closing remarks lived experience of epilepsy and discussion 16:00 – 18:00 Large-scale clinical data 14:30 Social until late: Depart for Topsham, session: session (chaired by Prof. Mark Richardson) ferry to Turf Hotel and BBQ Mrs. Lottie Pagram: My Epilepsy and Me Dr. Jonas Duun-Henriksen Mr. Neil and Mrs. Hannah Parker: Dr. Sharanya Desai Diagnosis and caring Dr. Levin Kuhlmann Mr. Simon Privett: My Epilepsy Journey - Prof. Jacqueline French and Sonya Can Epilepsy be a Positive? Dumanis (EFA) Miss Torie Robinson: The impact of temporal lobectomy on cognitive function, 18:00 – 19:00 Poster Session mood regulation and mental health 18:30 - 19:30 Mentoring session 19:00 Coach to conference dinner Contributed talk titles Dr. Beth Lopour Dynamics of EEG-based functional connectivity in infantile spasms and healthy infants Dr. Maxime Baud Multidien Chronotypes in Human Focal Epilepsy Dr. Jonas Duun-Henriksen Objective treatment optimization and what to learn from 11,774 hours of ultra long-term subcutaneous EEG from nine patients Dr. Sharanya Desai Therapy proposer and evaluation tools developed from mining big epilepsy data Dr. Levin Kuhlmann Epilepsyecosystem.org update: Searching for Seizure Prediction Solutions Dr. Thorsten Rings Seizure prediction and seizure control: cautionary tales from measuring resilience of the brain Dr. Dean Freestone Critical slowing as a biomarker for seizure susceptibility Drs. Miao Cao and Daniel Galvis Reducing the need for invasive intra-cranial monitoring for epilepsy surgery. Dr. Gerold Baier Implementing Horsley's dream: Stimulation-responses to uncover the epileptogenic network prior to epilepsy surgery Dr. John Bernabei Virtual resection predicts surgical outcome for drug resistant epilepsy Dr. Rasesh Joshi Seizure-related spatiotemporal fluctuations in infraslow networks in intracranial EEG and MEG Dr. Gabrielle Schroeder Slow shifts in seizure pathways in individual patients with focal epilepsy Prof. Bill Stacey Seeing the big picture: expanding the scope of electrical and biochemical biomarker research Prof. Premysl Jiruska Decrease in neuronal network resilience precedes seizures at multiple temporal scales. Venue The conference will be held in the Xfi building at the University of Exeter. Xfi Conference dinner The conference dinner is at Puerto Lounge on Tuesday 7pm, September 5th. There will be coaches from and back to the University. Social event The social event is a free ferry trip (weather permitting!) to the Turf Hotel followed by BBQ and drinks on Wednesday evening, September 4th.The BBQ will be at your own expense, but some drinks will be subsidised. There will be coaches from and back to the University. Map of Xfi building THE HENDERSON LECTURE THEATRE CONFERENCE ROOM 2 CONFERENCE ROOM 1 SEMIN AR RO O M C SEMIN AR RO O M B SEMIN AR RO O M A AT RI U M Talks: The Henderson Lecture Theatre Posters: Conference rooms 1 and 2 Lunch and coffee breaks: Atrium Epilepsy action coffee and chat space: Seminar room C ICTALS 2019: The Network Debates Organized by: Klaus Lehnertz, Björn Schelter and Hitten Zaveri Session 1: What is an epileptic network? 1. Debate: From pathologic to physiologic: is the epileptic network part of an existing large- scale brain network? Debaters: Yes: Hitten Zaveri vs No: Cathy Schevon Discussant: Fabrice Wendling 2. Debate: Are micro scale recordings pertinent for defining the epileptic network? Debaters: Yes: Premysl Jiruska vs No: John Jefferys Discussant: Mark Cook 3. Debate: From seconds to years: do we need all temporal scales to define an epileptic network? Debaters: Yes: Greg Worrell vs No: Andreas Schulze-Bonhage Discussant: Mark Richardson Session 2: How can we control an epileptic network? 4. Debate: Is it necessary to fully define the epileptic network to control it? Debaters: Yes: Rasesh Joshi vs No: Björn Schelter Discussant: Thorsten Rings 5. Debate: Is controlling seizures sufficient to control the epileptic network? Debaters: Yes: Viktor Jirsa vs No: Marc Goodfellow Discussant: Klaus Lehnertz 6. Debate: Does the epileptic network want to be controlled? Debaters: Yes: Christian Meisel vs No: Klaus Lehnertz Discussant: Piotr Suffczynski Guidelines: Each debate will be conducted over 30 minutes. There will be 6 minutes for each position (pro and con). This will be followed by brief comments by a discussant for up to 3 minutes. Following the comments by the discussant we will open to the floor for up to 15 minutes of discussion. Not only for scientists ICTALS 2019 is partnering with charities Epilepsy Research UK, Epilepsy Alliance and Epilepsy Action to bring together people with lived experience of epilepsy and scientists. The first day of the conference will be an educational day in which introductory talks will be given to build a bridge between the scientific community and the public. Then people with lived experience of epilepsy will share their testimonies. To aid in making the science accessible to the general public, there will be a buddy system, where appointed researchers from the University of Exeter will be available to answer any questions that may arise. Epilepsy Action will have a coffee and chat space where everyone will be welcome to talk and rest away from the main sessions of the conference.
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