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A Framework to Guide Selection of Chemical Alternatives This PDF is available from The National Academies Press at http://www.nap.edu/catalog.php?record_id=18872 A Framework to Guide Selection of Chemical Alternatives ISBN Committee on the Design and Evaluation of Safer Chemical Substitutions: 978-0-309-31013-0 A Framework to Inform Government and Industry Decision; Board on Chemical Sciences and Technology; Board on Environmental Studies and 334 pages Toxicology; Division on Earth and Life Studies; National Research Council 8.5 x 11 PAPERBACK (2014) Visit the National Academies Press online and register for... Instant access to free PDF downloads of titles from the NATIONAL ACADEMY OF SCIENCES NATIONAL ACADEMY OF ENGINEERING INSTITUTE OF MEDICINE NATIONAL RESEARCH COUNCIL 10% off print titles Custom notification of new releases in your field of interest Special offers and discounts Distribution, posting, or copying of this PDF is strictly prohibited without written permission of the National Academies Press. Unless otherwise indicated, all materials in this PDF are copyrighted by the National Academy of Sciences. Request reprint permission for this book Copyright © National Academy of Sciences. All rights reserved. A Framework to Guide Selection of Chemical Alternatives A FRAMEWORK TO GUIDE SELECTION OF CHEMICAL ALTERNATIVES Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Government and Industry Decision Board on Chemical Sciences and Technology Board on Environmental Studies and Toxicology Division on Earth and Life Studies National Research Council -PREPUBLICATION COPY- Copyright © National Academy of Sciences. All rights reserved. A Framework to Guide Selection of Chemical Alternatives THE NATIONAL ACADEMIES PRESS 500 Fifth Street, NW Washington, DC 20001 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. This project was supported by Contract EP-C-09-003, TO# 25 between the National Academy of Sciences and the U.S. Environmental Protection Agency. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the organizations or agencies that provided support for this project. International Standard Book Number Library of Congress Control Number Additional copies of this report are available from The National Academies Press 500 Fifth Street, NW Keck 360 Washington, DC 20001 800-624-6242 202-334-3313 (in the Washington metropolitan area) http://www.nap.edu Copyright 2014 by the National Academy of Sciences. All rights reserved. Printed in the United States of America. -PREPUBLICATION COPY- Copyright © National Academy of Sciences. All rights reserved. A Framework to Guide Selection of Chemical Alternatives The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Ralph J. Cicerone is president of the National Academy of Sciences. The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. C. D. Mote, Jr., is president of the National Academy of Engineering. The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Victor J. Dzau is president of the Institute of Medicine. The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy’s purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Ralph J. Cicerone and Dr. C. D. Mote, Jr., are chair and vice chair, respectively, of the National Research Council. www.national-academies.org iii -PREPUBLICATION COPY- Copyright © National Academy of Sciences. All rights reserved. A Framework to Guide Selection of Chemical Alternatives COMMITTEE TO REVIEW SAFER CHEMICAL SUBSTITUTIONS Members DAVID C. DORMAN (Chair), North Carolina State University ERIC J. BECKMAN, University of Pittsburgh PETER BEAK, University of Illinois, Urbana-Champaign JEROME J. CURA, Woods Hole Group Inc., MA ANNE FAIRBROTHER, Exponent Inc., WA NIGEL GREENE, Pfizer, CT CAROL HENRY, The George Washington University, DC HELEN HOLDER, Hewlett-Packard Company, CA JAMES E. HUTCHISON, University of Oregon GREGORY M. PAOLI, Risk Sciences International, ON JULIA B. QUINT, California Department of Public Health (retired) IVAN RUSYN, University of North Carolina, NC KATHLEEN SHELTON, DuPont, DE JOEL A. TICKNER, University of Massachusetts ADELINA VOUTCHKOVA, The George Washington University, DC MARTIN H. WOLF, Seventh Generation Inc., VT Staff MARILEE SHELTON-DAVENPORT, Study Director and Senior Program Officer, Board on Life Sciences KATHRYN HUGHES, Senior Program Officer, Board on Chemical Sciences and Technology ELLEN K. MANTUS, Senior Program Officer, Board on Environmental Studies and Toxicology JANET MULLIGAN, Research Associate, Board on Agriculture and Natural Resources MARILYN FENICHEL, Editor, Cassell & Fenichel Communications MIRSADA KARALIC-LONCAREVIC, Manager, Technical Information Center IVORY CLARKE, Senior Program Assistant, Board on Environmental Studies and Toxicology Sponsor U.S. ENVIRONMENTAL PROTECTION AGENCY iv -PREPUBLICATION COPY- Copyright © National Academy of Sciences. All rights reserved. A Framework to Guide Selection of Chemical Alternatives BOARD ON CHEMICAL SCIENCES AND TECHNOLOGY Members TIMOTHY SWAGER, (Co-Chair), Massachusetts Institute of Technology, Cambridge DAVID WALT,(Co-Chair), NAE, Tufts University, Medford, Massachusetts HÉCTOR D. ABRUÑA, Cornell University, Ithaca, New York JOEL C. BARRISH, Bristol-Myers Squibb, Princeton, New Jersey MARK A. BARTEAU, University of Michigan, Ann Arbor DAVID BEM, The Dow Chemical Company, Philadelphia, PA ROBERT G. BERGMAN, NAS, University of California, Berkeley JOAN BRENNECKE, NAE, University of Notre Dame, Indiana HENRY E. BRYNDZA, E. I. du Pont de Nemours & Company, Wilmington, Delaware MICHELLE V. BUCHANAN, Oak Ridge National Laboratory, Oak Ridge, Tennessee DAVID W. CHRISTIANSON, University of Pennsylvania, Philadelphia RICHARD EISENBERG, NAS, University of Rochester, New York JILL HRUBY, Sandia National Laboratories, Albuquerque, New Mexico FRANCES S. LIGLER, NAE, North Carolina State University, Raleigh SANDER G. MILLS, Merck Research Laboratories (Ret.), Scotch Plains, New Jersey JOSEPH B. POWELL, Shell, Houston, Texas ROBERT E. ROBERTS, Institute for Defense Analyses, Alexandria, Virginia PETER J. ROSSKY, NAS, The University of Texas at Austin DARLENE SOLOMON, Agilent Technologies, Santa Clara, California National Research Council Staff TERESA FRYBERGER, Director KATHRYN HUGHES, Senior Program Officer DOUGLAS FRIEDMAN, Senior Program Officer CARL GUSTAV-ANDERSON, Research Associate ELIZABETH FINKELMAN, Program Coordinator NAWINA MATSHONA, Senior Program Assistant CAMLY TRAN, Postdoctoral Fellow v -PREPUBLICATION COPY- Copyright © National Academy of Sciences. All rights reserved. A Framework to Guide Selection of Chemical Alternatives BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY Members ROGENE F. HENDERSON (Chair), Lovelace Respiratory Research Institute, Albuquerque, NM PRAVEEN AMAR, Independent Consultant, Lexington, MA RICHARD A. BECKER, American Chemistry Council, WASHINGTON,DC MICHAEL J. BRADLEY, M.J. Bradley & Associates, Concord, MA JONATHAN Z. CANNON, University of Virginia, Charlottesville, VA GAIL CHARNLEY ELLIOTT, HealthRisk Strategies, Washington, DC DOMINIC M. DITORO, University of Delaware, Newark, DE DAVID C. DORMAN, North Carolina State University, Raleigh, NC CHARLES T. DRISCOLL,JR., Syracuse University, Syracuse, NY WILLIAM H. FARLAND, Colorado State University, Fort Collins, CO LYNN R. GOLDMAN, The
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