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Chengdu Biopurify Phytochemicals Ltd. TCM compound library01 TCM compound library20170801 Chengdu Biopurify Phytochemicals Ltd. www.phytopurify.com Biopurify TCM compounds library offers over 4600 compounds, many of which are unique to us. *There are 3 sub-libraries to meet different budgets and demands. Selection is available across the library, and among compound types (e.g. Alkaloids, Flavonoids, Terpenoids, etc.) * All compounds passed the HPLC, MS and NMR tests. Most of our products are provided with at least 95% purity. High purity minimize the occurrence of false positives. * All compounds can be provided in individual packages from 2mg to 10mg. * All compounds can be provided with the SDF file for computer screening. * Large scale production is also available on demand. For many compounds, we already have a few grams or more in stock and ready for sale. Please contact us with the specific compounds needed. Catalog No English name CAS Number Type of Compound Formula MolWeight BP0001 1,2,3,4,6-Pentagalloylglucose 14937-32-7 Polyphenols C41H32O26 940.68 BP0005 1,3-Dicaffeoylquinic acid 30964-13-7 Phenylpropanoids C25H24O12 516.46 BP0006 1,5-Dicaffeoylquinic acid 19870-46-3 Phenylpropanoids C25H24O12 516.46 BP0008 1,8-Dihydroxyanthraquinone 117-10-2 Anthraquinones C14H8O4 240.21 BP0011 10-deacetylbaccatin III 32981-86-5 Diterpenoids C29H36O10 544.60 BP0012 10-Deacetyltaxol 78432-77-6 Diterpenoids C45H49NO13 811.88 BP0013 10-Gingerol 23513-15-7 Phenols C21H34O4 350.50 BP0014 10-Hydroxycamptothecin 19685-09-7 Alkaloids C20H16N2O5 364.36 BP0016 10-Methoxycamptothecin 19685-10-0 Alkaloids C21H18N2O5 378.38 BP0018 11-Keto-beta-boswellic acid 17019-92-0 Triterpenoids C30H46O4 470.69 BP0019 11-Oxomogroside V 126105-11-1 Triterpenoids C60H100O29 1285.43 BP0021 Phorbol-12-Myristate-13-Acetate 16561-29-8 Diterpenoids C36H56O8 616.84 BP0023 13-Acetyl-9-dihydrobaccatin III 142203-65-4 Diterpenoids C33H42O12 630.69 BP0024 14-Benzoylaconine 466-24-0 Alkaloids C32H45NO10 603.71 BP0026 14-hydroxysprengerinin C 1111088-89-1 Steroids C44H70O17 871.03 BP0027 15,16-Dihydrotanshinone I 87205-99-0 Diterpenoids C18H14O3 278.31 BP0030 1-Deoxynojirimycin 19130-96-2 Alkaloids C6H13NO4 163.17 BP0032 1-Monomyristin 589-68-4 Aliphatics C17H34O4 302.46 BP0034 1-Octacosanol 557-61-9 Aliphatics C28H58O 410.77 BP0035 2''-O-beta-L-galactopyranosylorientin 861691-37-4 Flavonoids C27H30O16 610.52 BP0036 2''-O-Galloylhyperin 53209-27-1 Flavonoids C28H24O16 616.48 BP0038 2''-Rhamnosylvitexin 64820-99-1 Flavonoids C27H30O14 578.52 2,3,5,4'-Tetrahydroxyl-diphenylethylene- BP0039 82373-94-2 Phenols C H O 406.39 2-O-beta-D-glucoside 20 22 9 BP0040 20(R)-Ginsenoside Rg3 38243-03-7 Triterpenoids C42H72O13 785.03 BP0041 20(R)-Ginsenoside Rh1 80952-71-2 Triterpenoids C36H62O9 638.88 BP0042 20(R)-Ginsenoside Rh2 112246-15-8 Triterpenoids C36H62O8 622.88 BP0043 20(R)-Notoginsenoside R2 948046-15-9 Triterpenoids C41H70O13 771.00 BP0044 20(R)-Protopanaxadiol 7755-01-3 Triterpenoids C30H52O3 460.74 BP0045 20(S)-Protopanaxadiol 30636-90-9 Triterpenoids C30H52O3 460.74 BP0047 2-Acetylacteoside 94492-24-7 Phenylpropanoids C31H38O16 666.63 BP0049 2-Borneol 507-70-0 Monoterpenoids C10H18O 154.25 BP0053 3,3'-Di-O-methylellagic acid 2239-88-5 Phenols C16H10O8 330.25 BP0055 3,4-Dicaffeoylquinic acid 14534-61-3 Phenylpropanoids C25H24O12 516.46 BP0056 3,5-Dicaffeoylquinic acid 2450-53-5 Phenylpropanoids C25H24O12 516.46 BP0058 3-Acetylaconitine 77181-26-1 Alkaloids C36H49NO12 687.78 BP0061 3-Butylidenephthalide 551-08-6 Miscellaneous C12H12O2 188.23 BP0063 3'-hydroxygenkwanin 20243-59-8 Flavonoids C16H12O6 300.27 BP0064 3'-hydroxyPuerarin 117060-54-5 Flavonoids C21H20O10 432.38 BP0065 3-Isomangostin 19275-46-8 Xanthones C24H26O6 410.47 BP0067 3'-MethoxyPuerarin 117047-07-1 Flavonoids C22H22O10 446.41 BP0068 3-O-acetyloleanolic acid 4339-72-4 Triterpenoids C32H50O4 498.75 BP0071 Oleanonic acid 17990-42-0 Triterpenoids C30H46O3 454.70 BP0072 Ursonic acid 6246-46-4 Triterpenoids C30H46O3 454.70 BP0074 4,5-Dicaffeoylquinic acid 57378-72-0 Phenylpropanoids C25H24O12 516.46 BP0075 4'-Demethylepipodophyllotoxin 6559-91-7 Lignans C21H20O8 400.38 BP0076 4'-Demethylpodophyllotoxin 40505-27-9 Lignans C21H20O8 400.38 BP0077 4-Hydroxyisoleucine 781658-23-9 Amino Acids C6H13NO3 147.17 BP0078 4'-O-Glucosylvitexin 38950-94-6 Flavonoids C27H30O15 594.52 BP0080 5,15-Diacetyl-3-benzoyllathyrol 218916-52-0 Diterpenoids C31H38O7 522.64 BP0081 5,7-Dihydroxychromone 31721-94-5 Flavonoids C9H6O4 178.14 BP0083 5-Caffeoylquinic acid 906-33-2 Phenylpropanoids C16H18O9 354.31 BP0088 5-O-Demethylnobiletin 2174-59-6 Flavonoids C20H20O8 388.37 BP0089 5-O-methylvisammioside 84272-85-5 Phenols C22H28O10 452.46 BP0092 6-Gingerol 23513-14-6 Phenols C17H26O4 294.39 Natural Product Compound Library www.phytopurify.com 1 Chengdu Biopurify Phytochemicals Ltd. TCM compound library01 BP0095 6-Shogaol 555-66-8 Phenols C17H24O3 276.38 BP0097 7-beta-Hydroxylathyrol 34208-98-5 Diterpenoids C20H30O5 350.46 BP0098 7-Epitaxol 105454-04-4 Diterpenoids C47H51NO14 853.92 BP0099 7-Ethyl-10-Hydroxycamptothecin 86639-52-3 Alkaloids C22H20N2O5 392.41 BP0100 7-Ethylcamptothecin 78287-27-1 Alkaloids C22H20N2O4 376.41 BP0101 7-Hydroxycoumarin 93-35-6 Coumarins C9H6O3 162.14 BP0102 7-O-Methyl morroniside 41679-97-4 Iridoids C18H28O11 420.41 BP0103 7-O-Methylchrysin 520-28-5 Flavonoids C16H12O4 268.27 BP0105 8-Acetylharpagide 6926-14-3 Iridoids C17H26O11 406.38 BP0106 8-Desoxygartanin 33390-41-9 Xanthones C23H24O5 380.44 BP0107 8-Geranopsoralen 7437-55-0 Coumarins C21H22O4 338.40 BP0108 8-Gingerol 23513-08-8 Phenols C19H30O4 322.45 BP0110 8-O-Acetyl shanzhiside methyl ester 57420-46-9 Iridoids C19H28O12 448.42 BP0111 9-Methoxycamptothecin 39026-92-1 Alkaloids C21H18N2O5 378.38 BP0112 Abrine 526-31-8 Alkaloids C12H14N2O2 218.26 BP0114 Acacetin 480-44-4 Flavonoids C16H12O5 284.27 BP0115 Acaciin 480-36-4 Flavonoids C28H32O14 592.55 BP0116 Acetate gossypol 12542-36-8 Phenols C32H34O10 578.61 BP0117 Acetylcorynoline 18797-80-3 Alkaloids C23H23NO6 409.44 BP0118 Acetylshikonin 24502-78-1 Quinones C18H18O6 330.34 BP0121 Aconitine 302-27-2 Alkaloids C34H47NO11 645.75 BP0124 Acteoside 61276-17-3 Phenylpropanoids C29H36O15 624.59 BP0125 Agnuside 11027-63-7 Iridoids C22H26O11 466.44 BP0126 Agrimol B 55576-66-4 Phenols C37H46O12 682.76 BP0128 Ailanthone 981-15-7 Diterpenoids C20H24O7 376.41 BP0130 Ajugol 52949-83-4 Iridoids C15H24O9 348.35 BP0134 Albiflorin 39011-90-0 Monoterpenoids C23H28O11 480.47 BP0135 Alismoxide 87701-68-6 Sesquiterpenoids C15H26O2 238.37 BP0136 Alisol B Acetate 26575-95-1 Triterpenoids C32H50O5 514.75 BP0137 Alisol A 19885-10-0 Triterpenoids C30H50O5 490.73 BP0138 Alisol A,24-acetate 18674-16-3 Triterpenoids C32H52O6 532.76 BP0140 Alkannin 517-88-4 Quinones C16H16O5 288.30 BP0141 Allicin 539-86-6 Miscellaneous C6H10OS2 162.27 BP0142 Alliin 556-27-4 Alkaloids C6H11NO3S 177.22 BP0143 Allocryptopine 485-91-6 Alkaloids C21H23NO5 369.42 BP0145 Alnustone 33457-62-4 Phenols C19H18O 262.35 BP0146 Aloe emodin 481-72-1 Anthraquinones C15H10O5 270.24 BP0148 Aloenin A 38412-46-3 Anthraquinones C19H22O10 410.38 BP0149 Aloin A 1415-73-2 Anthraquinones C21H22O9 418.40 BP0150 Aloin B 28371-16-6 Anthraquinones C21H22O9 418.40 BP0151 Aloin(mixture of A&B) 8015-61-0 Anthraquinones C21H22O9 418.40 BP0152 Alpha Cyperone 473-08-5 Sesquiterpenoids C15H22O 218.34 BP0153 Alpha-Boswellic acid 471-66-9 Triterpenoids C30H48O3 456.71 BP0154 Alpha-Hederin 27013-91-8 Triterpenoids C41H66O12 750.97 BP0155 Alpha-Mangostin 6147-11-1 Xanthones C24H26O6 410.47 BP0160 Alpinetin 36052-37-6 Flavonoids C16H14O4 270.28 BP0161 Amentoflavone 1617-53-4 Flavonoids C30H18O10 538.46 BP0162 Amygdalin 29883-15-6 Phenols C20H27NO11 457.43 BP0164 Andrographolide 5508-58-7 Diterpenoids C20H30O5 350.46 BP0165 Androsin 531-28-2 Miscellaneous C15H20O8 328.32 BP0166 Anemarsaponin B 139051-27-7 Steroids C45H74O18 903.07 BP0167 Anemarsaponin E 136565-73-6 Steroids C46H78O19 935.11 BP0168 Anemosapogenin 85999-40-2 Triterpenoids C30H48O4 472.71 BP0169 Anemoside A3 129724-84-1 Triterpenoids C41H66O12 750.97 BP0170 Anemoside B4 129741-57-7 Triterpenoids C59H96O26 1221.39 BP0171 Angelicin 523-50-2 Coumarins C11H6O3 186.17 BP0172 Angoroside C 115909-22-3 Phenylpropanoids C36H48O19 784.76 BP0174 Anisodamine 17659-49-3 Alkaloids C17H23NO4 305.37 BP0176 Anwuligan 107534-93-0 Lignans C20H24O4 328.41 BP0177 Apigenin 520-36-5 Flavonoids C15H10O5 270.24 Apigenin-7-O -(2G- BP0178 174284-20-9 Flavonoids C H O 740.66 rhamnosyl)gentiobioside 33 40 19 BP0179 Apigenin-7-O-glucuronide 29741-09-1 Flavonoids C21H18O11 446.36 BP0181 Apigetrin 578-74-5 Flavonoids C21H20O10 432.38 BP0182 Apiin 26544-34-3 Flavonoids C26H28O14 564.50 BP0185 Arbutin 497-76-7 Phenols C12H16O7 272.25 BP0186 Arctigenin 7770-78-7 Lignans C21H24O6 372.42 BP0187 Arctiin 20362-31-6 Lignans C27H34O11 534.56 BP0188 Ardisiacrispin A 23643-61-0 Triterpenoids C52H84O22 1061.22 Natural Product Compound Library www.phytopurify.com 2 Chengdu Biopurify Phytochemicals Ltd. TCM compound library01 BP0189 Arecoline hydrobromide 300-08-3 Alkaloids C8H14BrNO2 236.11 BP0190 Arenobufagin 464-74-4 Steroids C24H32O6 416.51 BP0192 Aristolochic acid A 313-67-7 Miscellaneous C17H11NO7 341.28 BP0193 Aristolochic Acid B 475-80-9 Miscellaneous C16H9NO6 311.25 BP0194 Aristololactam 13395-02-3 Alkaloids C17H11NO4 293.28 BP0195 Artemether 71963-77-4 Sesquiterpenoids C16H26O5 298.38 BP0196 Artemisic acid 80286-58-4 Sesquiterpenoids C15H22O2 234.34 BP0197 Artemisinin 63968-64-9 Sesquiterpenoids C15H22O5 282.34 BP0198 Artesunate 88495-63-0 Sesquiterpenoids C19H28O8
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    Characterization and Differentiation of Spanish Vinegars from Jerez And

    foods Article Characterization and Differentiation of Spanish Vinegars from Jerez and Condado de Huelva Protected Designations of Origin Enrique Durán-Guerrero 1,* ,Mónica Schwarz 2, M. Ángeles Fernández-Recamales 3, Carmelo G. Barroso 1 and Remedios Castro 1 1 Analytical Chemistry Department—IVAGRO, Faculty of Sciences, University of Cadiz, 11510 Puerto Real, Spain 2 “Salus Infirmorum” Faculty of Nursing, University of Cadiz, 11001 Cadiz, Spain 3 Department of Chemistry, Faculty of Experimental Sciences, University of Huelva, 21007 Huelva, Spain * Correspondence: [email protected]; Tel.: +34-956-01645 Received: 23 July 2019; Accepted: 9 August 2019; Published: 12 August 2019 Abstract: Thirty one Jerez vinegar samples and 33 Huelva vinegar samples were analyzed for polyphenolic and volatile compound content in order to characterize them and attempt to differentiate them. Sixteen polyphenolic compounds were quantified by means of ultraperformance liquid chromatography method with diode array detection (UPLC–DAD), and 37 volatile compounds were studied by means of stir bar sorptive extraction–gas chromatography–mass spectrometry (SBSE–GC–MS). Spectrophotometric CIELab parameters were also measured for all the samples. The results obtained from the statistical multivariate treatment of the data evidenced a clear difference between vinegars from the two geographical indications with regard to their polyphenolic content, with Jerez vinegars exhibiting a greater phenolic content. Differentiation by the volatile compound content was, however, not so evident. Nevertheless, a considerable differentiation between the two groups of vinegars based on their volatile fraction was achieved. This may bring to light the grape varieties and geographical factors that have a clear influence on such differences.
  • (12) United States Patent (10) Patent No.: US 8,980,319 B2 Park Et Al

    (12) United States Patent (10) Patent No.: US 8,980,319 B2 Park Et Al

    US00898O319B2 (12) United States Patent (10) Patent No.: US 8,980,319 B2 Park et al. (45) Date of Patent: *Mar. 17, 2015 (54) METHODS OF PRODUCING STABILIZED A613 L/445 (2006.01) SOLID DOSAGE PHARMACEUTICAL A613 L/47 (2006.01) COMPOSITIONS CONTAINING A6II 45/06 (2006.01) MORPHINANS A63/67 (2006.01) (52) U.S. Cl. (71) Applicant: Mallinckrodt LLC, Hazelwood, MO CPC ............. A6 IK3I/485 (2013.01); A61 K9/1652 (US) (2013.01); A61 K9/2031 (2013.01); A61 K 9/2081 (2013.01); A61 K9/2086 (2013.01); (72) Inventors: Jae Han Park, Olivette, MO (US); A6IK9/2095 (2013.01); A61 K9/5042 Tiffani Eisenhauer, Columbia, IL (US); (2013.01); A61 K3I/4355 (2013.01); A61 K Spainty,S.Isna Gupta, F11llsborough, 31/4375A6 (2013.01); IK3I/445 gets (2013.01); it' A6 (2013.01); IK3I/47 Stephen Overholt, Middlesex, NJ (US) (2013.01); A61K 45/06 (2013.01); A61 K 9/2013 (2013.01); A61 K9/209 (2013.01); (73) Assignee: Mallinckrodt LLC, Hazelwood, MO A6 IK3I/167 (2013.01) (US) USPC ........... 424/472: 424/465; 424/468; 424/490; c - r - 514/282; 514/289 (*) Notice: Subject to any disclaimer, the term of this (58) Field of Classification Search patent is extended or adjusted under 35 N U.S.C. 154(b)b) by 0 daysyS. Seeone application file for complete search history. This patent is Subject to a terminal dis claimer. (56) References Cited (21) Appl. No.: 14/092.375 U.S. PATENT DOCUMENTS (22) Filed: Nov. 27, 2013 2008, 0026052 A1 ck 1/2008 Schoenhard .................
  • Enzyme-Site Blocking Combined with Optimization of Molecular Docking for Efficient Discovery of Potential Tyrosinase Specific In

    Enzyme-Site Blocking Combined with Optimization of Molecular Docking for Efficient Discovery of Potential Tyrosinase Specific In

    molecules Article Enzyme-Site Blocking Combined with Optimization of Molecular Docking for Efficient Discovery of Potential Tyrosinase Specific Inhibitors from Puerariae lobatae Radix Haichun Liu 1,2,†, Yitian Zhu 1,† , Ting Wang 1, Jin Qi 1,* and Xuming Liu 3,* 1 Jiangsu key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China; [email protected] (H.L.); [email protected] (Y.Z.); [email protected] (T.W.) 2 School of Science, China Pharmaceutical University, Nanjing 211198, China 3 School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China * Correspondence: [email protected] (J.Q.); [email protected] (X.L.); Tel.: +86-025-8618-5157 (J.Q.); +86-025-8618-5397 (X.L.) † These authors contributed equally to this work. Received: 1 August 2018; Accepted: 7 October 2018; Published: 11 October 2018 Abstract: Enzyme inhibitors from natural products are becoming an attractive target for drug discovery and development; however, separating enzyme inhibitors from natural-product extracts is highly complex. In this study, we developed a strategy based on tyrosinase-site blocking ultrafiltration integrated with HPLC-QTOF-MS/MS and optimized molecular docking to screen tyrosinase inhibitors from Puerariae lobatae Radix extract. Under optimized ultrafiltration parameters, we previously used kojic acid, a known tyrosinase inhibitor, to block the tyrosinase active site in order to eliminate false-positive results. Using this strategy, puerarin, mirificin, daidzin and genistinc were successfully identified as potential ligands, and after systematic evaluation by several docking programs, the rank of the identified compounds predicted by computational docking was puerarin > mirificin > kojic acid > daidzin ≈ genistin, which agreed with the results of tyrosinase-inhibition assays.
  • Transcriptome Analysis of Pueraria Candollei Var

    Transcriptome Analysis of Pueraria Candollei Var

    Suntichaikamolkul et al. BMC Plant Biology (2019) 19:581 https://doi.org/10.1186/s12870-019-2205-0 RESEARCH ARTICLE Open Access Transcriptome analysis of Pueraria candollei var. mirifica for gene discovery in the biosyntheses of isoflavones and miroestrol Nithiwat Suntichaikamolkul1, Kittitya Tantisuwanichkul1, Pinidphon Prombutara2, Khwanlada Kobtrakul3, Julie Zumsteg4, Siriporn Wannachart5, Hubert Schaller4, Mami Yamazaki6, Kazuki Saito6, Wanchai De-eknamkul7, Sornkanok Vimolmangkang7 and Supaart Sirikantaramas1,2* Abstract Background: Pueraria candollei var. mirifica, a Thai medicinal plant used traditionally as a rejuvenating herb, is known as a rich source of phytoestrogens, including isoflavonoids and the highly estrogenic miroestrol and deoxymiroestrol. Although these active constituents in P. candollei var. mirifica have been known for some time, actual knowledge regarding their biosynthetic genes remains unknown. Results: Miroestrol biosynthesis was reconsidered and the most plausible mechanism starting from the isoflavonoid daidzein was proposed. A de novo transcriptome analysis was conducted using combined P. candollei var. mirifica tissues of young leaves, mature leaves, tuberous cortices, and cortex-excised tubers. A total of 166,923 contigs was assembled for functional annotation using protein databases and as a library for identification of genes that are potentially involved in the biosynthesis of isoflavonoids and miroestrol. Twenty-one differentially expressed genes from four separate libraries were identified as candidates involved in these biosynthetic pathways, and their respective expressions were validated by quantitative real-time reverse transcription polymerase chain reaction. Notably, isoflavonoid and miroestrol profiling generated by LC-MS/MS was positively correlated with expression levels of isoflavonoid biosynthetic genes across the four types of tissues. Moreover, we identified R2R3 MYB transcription factors that may be involved in the regulation of isoflavonoid biosynthesis in P.