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Annual Report 2013 2013 ANNUAL REPORT McCuskerAlzheimer’s Research Foundation Inc Suite 22 Tel: +61 8 9347 4200 Hollywood Medical Centre Fax: +61 8 9347 4299 85 Monash Avenue Email: [email protected] Nedlands WA 6009 Australia www.alzheimers.com.au THANKS TO ALL OUR SUPPORTERS... Alzheimer’s disease is one of the most • Spending on Dementia will surpass any Cowan University whose contributions of important public health problems we other health condition laboratory space, salaries and funding of face. It has a devastating impact research costs are invaluable. In 2010 dementia affected 23,000 WA on individuals and their families, people and this figure will rise to 61,000 Particular thanks go to a number of the community and the economy. by 2030. It is estimated that by 2050 significant donors who are acknowledged Unfortunately, compared to many other there will be an estimated 125,000 cases personally by Enzo Sirna in his major health areas such as heart disease in WA with 18 new cases every day. It is Chairman’s Report. and cancer, it receives little funding for predicted that the most rapid growth in research to discover treatments. We are grateful to community groups WA will occur in the next 10 years such as Lions clubs WA, Rotary and Emerging trends in Alzheimer’s disease The support given by the public to the Freemasons who support our efforts to statistics are amazing. fight against Alzheimer’s disease is of find a cure for Alzheimer’s disease. Our • There are 4.6 million new cases every the utmost importance. Without the developing partnership with the Lions year. very generous contributions of time Clubs International (WA) is particularly and money made by individuals and appreciated. • The number of people with Dementia corporations, the major research being is expected to double every 20 years Volunteers make an invaluable undertaken here in WA, at the McCusker and is projected to reach 115 million contribution. Their contributions as Alzheimer’s Research Foundation, would by 2050, with 81.1 million patients by research volunteers and assistance in struggle. 2040. fund raising and promotion are critical We are very grateful to our many to our efforts. Special thanks go to • 43% of cases need significant care supporters who share our vision of a the volunteers of the Lions McCusker (equivalent to a Nursing Home.) world where Alzheimer’s disease is Committee who work tirelessly to support • Total estimated worldwide cost of treatable and preventable and our belief and promote the work of Professor dementia in 2010 was $US604 billion that the research occurring here in Martins and his team. or nearly 1% of global GDP. WA can make major contributions to Finally, there are many more important defeating Alzheimer’s. • “If Alzheimer’s were a country, it would supporters that have not been singled be the 18th largest economy based on We are especially thankful to the out, however we wish to acknowledge GDP.” McCusker family, particularly Malcolm, their generous support, along with the • Within 2 decades dementia will be Carolyn and Tonya for their tremendous support of many members of the public. the third greatest source of health support and assistance over many years. and residential aged care spending – Special mention must also be made to approx. 1% of GDP Hollywood Private Hospital and Edith 2 CONTENTS Chairman’s Report ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... 4 Research Report ................................................ 6 Diagnosis . ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... 8 Prevention and Treatment.. ... ... ... ... ... ... ... ... ... ... ... .. 12 Collaborations.................................................. 26 Publications.. ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... .. 28 Grants.. ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... .. 32 Visits and Presentations ... ... ... ... ... ... ... ... ... ... ... ... .. 32 Clinical Trials Division ... ... ... ... ... ... ... ... ... ... ... ... ... .. 33 Alzhyme ........................................................ 36 Community Outreach ... ... ... ... ... ... ... ... ... ... ... ... ... .. 38 Board Members ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... .. 40 Annual Report Financial Tables................................ 41 Notes ........................................................... 54 Board of Director 2013 3 ANNUAL REPORT ANNUAL 2013 Seated from left: Rob Davies, Professor Ralph Martins; Enzo Sirna, Dr Terry Bayliss Standing from left: Peter Stephens, Deborah Doncon, Jenny Day, Assoc. Professor David Groth, Ron Bennetts, Russell Delroy. CHAIRMAN’S REPORT - ENZO SIRNA Since its inception, the McCusker aim of bringing important clinical trials “ Alzheimer’s Research Foundation has to Western Australia. Among these we maintained a constant and important have the Testosterone and Fish Oil Study presence in assisting our research team, (where over 3000 people registered so capably led by Prof. Ralph Martins, in interest to participate, but only 200 its goal to find prevention and ultimately, chosen to be assessed), the Tommorrow a cure for Alzheimer’s disease. (Tomm40) Study, the Nutritional The importance of this world class Supplements Study (investigating research has not been underestimated Biocurcumax and Amlamax), the by the 2013 Members of the Board of Australian Imaging, Biomarkers and the McCusker Alzheimer’s Research Lifestyle (AIBL) Project and the Karviah Foundation. The Board has recognised Study (in conjunction with Anglican the challenges associated with the Retirement Homes in Sydney). escalating research demands and Furthermore, the purchase of a new PET the commitment required to give CT Scanner in 2013, due to an innovative Prof. Martins and his team maximum partnership with Oceanic Medical opportunities to continue to be key Imaging, the McCusker Alzheimer’s research contributors at a world level. Research Foundation and the estate The Board also values key partnerships of the late Dr. Jean Murray-Jones, will in assisting with the delivery of enhance Alzheimer’s disease neuro outcomes linked to our research. These imaging. The PET CT Scanner permits partnerships allow the quality of research shorter scan times, decreased radiation to be progressed not only at a state level, exposure and will assist in getting quicker but also at national and international results with more accurate scanning. levels with far reaching benefits. It is a In order to maintain the essential and recognised fact the McCusker Alzheimer’s ongoing support at an operational Research Foundation has one of the level, the Board has identified essential world’s richest databases associated with requirements which will need to be its projects and clinical trials, allowing for implemented as soon as possible to greater depth and quality of research as keep pace with the rapid expansion Prof. Martins and his team strive, with in the research area. It has therefore 4 excellence, in their endeavour to find a commenced a review process aimed cure for this ever growing disease, with at strengthening its infrastructure 4.6 million new cases of Alzheimer’s and providing a key platform for the disease diagnosed each year. implementation of future strategic Prof. Martins and his research team planning requirements. work closely with Dr Roger Clarnette The McCusker Alzheimer’s Research and the Clinical Trials Division with the Foundation is indebted to its many benefactors, partners, donors, the generous contribution towards the the Golf Day at the Royal Perth Golf Club. organisations and sponsors who believe new neuroscience building (of which The McCusker Alzheimer’s Research in the cause and who continue to support the McCusker Foundation will be a key Foundation was pleased to collaborate our endeavours. We are particularly partner) and the Government of Western with Alzheimer’s Australia (WA) for the grateful to our Patron, His Excellency, Australia for assisting with our cause. World Alzheimer’s Day and the combined Malcolm McCusker AC CVO QC, to The McCusker Foundation is pleased to event held at the Government House Mrs Tonya McCusker and to Carolyn have Maggie Beer as an ambassador for Ballroom was very well received. McCusker, for their unwavering support our cause and her presence is always of the Foundation. The McCusker family I would like to thank all members of inspirational. The fundraising dinner the Board, the Executive, staff, Prof. has been the backbone of the Foundation held at the Perth Convention Centre in for many years and has inspired many Martins and the research team for December 2013, “Maggie Beer and the your considerate and passionate other benefactors to contribute as well. Five Chefs”, was a huge success and The Board also recognises the significant commitment to a very important cause. we are indeed grateful for the support I am also appreciative of the support contribution by our Vice-Patron, Mrs received by some of Perth’s leading chefs, Terrie Delroy and her family. you have given me as a very privileged including Chris Taylor, Alain Fabregues, Chairman of the McCusker Alzheimer’s Every contribution made to the Foundation, Neal Jackson, Giuseppe Pagliaricci and Research Foundation. I would also like no matter how big or how small, whether Richard Taylor. Franklin Tate provided to acknowledge the commitment of our financial or in kind, is gratefully accepted excellent wines for the evening and Eric previous Chairman, Mr Graham Nixon, who because
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