SUPPLEMENTARY MATERIAL

Burden of illness among patients with -related

Monica Frazer, PhD; Victor Abler, DO; Rachel Halpern, PhD; Ben Skoog, PharmD; and Nazia Rashid, PharmD

Supplementary Table 1. Diagnosis and Medication Code List

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Supplementary Table 1. Diagnosis and Medication Code List Code Code Type Description Psychosis Inclusion 290.12 ICD-9 Dx Presenile dementia with delusional features 290.20 ICD-9 Dx Senile dementia with delusional features 290.42 ICD-9 Dx with 290.8 ICD-9 Dx Other specified senile psychotic conditions 290.9 ICD-9 Dx Unspecified senile psychotic condition 293.81 ICD-9 Dx Psychotic disorder with delusions in conditions classified elsewhere Psychotic disorder with in conditions classified 293.82 ICD-9 Dx elsewhere 297.1 ICD-9 Dx 298.0 ICD-9 Dx Depressive type psychosis 298.1 ICD-9 Dx Excitative type psychosis 298.4 ICD-9 Dx Psychogenic paranoid psychosis 298.8 ICD-9 Dx Other and unspecified reactive psychosis 298.9 ICD-9 Dx Unspecified psychosis 368.16 ICD-9 Dx Psychophysical visual disturbances 780.1 ICD-9 Dx Hallucinations Psychotic disorder with hallucinations due to known physiological F060 ICD-10 Dx condition Psychotic disorder with delusions due to known physiological F062 ICD-10 Dx condition F22 ICD-10 Dx Delusional disorders F23 ICD-10 Dx Brief psychotic disorder Other psychotic disorder not due to a substance or known F28 ICD-10 Dx physiological condition Unspecified psychosis not due to a substance or known physiological F29 ICD-10 Dx condition H5316 ICD-10 Dx Psychophysical visual disturbances R440 ICD-10 Dx Auditory hallucinations R441 ICD-10 Dx Visual hallucinations R442 ICD-10 Dx Other hallucinations R443 ICD-10 Dx Hallucinations, unspecified Dementia Inclusion 331.82 ICD-9 Dx Dementia with Lewy bodies G3183 ICD-10 Dx Dementia with Lewy bodies 290.0 ICD-9 Dx Senile dementia, uncomplicated 290.10 ICD-9 Dx Presenile dementia, uncomplicated 290.13 ICD-9 Dx Presenile with depressive features 290.21 ICD-9 Dx Senile dementia with depressive features Dementia in conditions classified elsewhere without behavioral 294.10 ICD-9 Dx disturbance 294.11 ICD-9 Dx Dementia in conditions classified elsewhere with behavior disturbance 331.11 ICD-9 Dx Pick’s disease 331.19 ICD-9 Dx Other 2

797 ICD-9 Dx Senility without mention of psychosis G3101 ICD-10 Dx Pick’s disease G3109 ICD-10 Dx Other frontotemporal dementia G311 ICD-10 Dx Senile degeneration of brain, not classified elsewhere Dementia in other diseases classified elsewhere without behavioral F0280 ICD-10 Dx disturbance Dementia in other diseases classified elsewhere with behavioral F0281 ICD-10 Dx disturbance 290.40 ICD-9 Dx Vascular dementia, uncomplicated 290.43 ICD-9 Dx Vascular dementia, with depressed mood 438.0 ICD-9 Dx Cognitive deficits due to cerebrovascular disease F0150 ICD-10 Dx Vascular dementia without behavioral disturbance F0151 ICD-10 Dx Vascular dementia with behavioral disturbance 294.20 ICD-9 Dx Dementia, unspecified, without behavioral disturbance 294.21 ICD-9 Dx Dementia, unspecified, with behavioral disturbance F0390 ICD-10 Dx Unspecified dementia without behavioral disturbance F0391 ICD-10 Dx Unspecified dementia with behavioral disturbance Paralysis agitans *must have ≥1 of the dementia codes (294.10, 294.11, 294.20, 332.0 ICD-9 Dx 294.21). Parkinson’s disease patients with a claim for dementia with codes other than those listed here were included in the category corresponding to that type of dementia Parkinson’s disease *must have ≥1 of the dementia codes (F0280, F0281, F0390, F0391). G20 ICD-10 Dx Parkinson’s disease patients with a claim for dementia with codes other than those listed here were included in the category corresponding to that type of dementia Medication Names Dementia Treatments Rivastigmine, transdermal; donepezil & memantine; memantine hydrochloride; galantamine hydrobromide; rivastigmine tartrate; donepezil hydrochloride; tacrine hydrochloride Atypical Antipsychotics Aripiprazole; asenapine; brexpiprazole; cariprazine; clozapine; iloperidone; lurasidone; olanzapine; olanzapine & fluoxetine; paliperidone, or as palmitate; quetiapine fumarate; quetiapine fumarate, extended release; risperidone; risperidone, long-acting injectable; ziprasidone hydrochloride; ziprasidone mesylate Typical Antipsychotics Chlorpromazine hydrochloride; fluphenazine hydrochloride; fluphenazine, decanoate or enanthate; haloperidol, or as lactate; loxapine, succinate or hydrochloride; molindone hydrochloride; perphenazine; perphenazine & amitriptyline; pimozide; promazine hydrochloride; thioridazine hydrochloride; thiothixene; trifluoperazine hydrochloride; triflupromazine hydrochloride Other Antipsychotics Dextromethorphan HBr & quinidine sulfate; divalproex sodium or valproate sodium

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