DOCSLIB.ORG

Patients Seek Natural Alternatives to Nsaids

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Patients Seek Natural Alternatives to Nsaids 52 Pain Medicine C LINICAL P SYCHIATRY N EWS • July 2005 Patients Seek Natural Alternatives to NSAIDs BY DOUG BRUNK phenolic glycosides, tannins, and fla- la, Fraxinus excelsior, and Solidago virgaurea. Complement. Altern. Med. 2004;4:13). San Diego Bureau vanoids. In a double-blind, placebo-con- Of the nine randomized, controlled trials Ǡ SAMe (S-adenosylmethionine). This trolled trial of 21 patients who took 240 involving phytodolor, those with a place- is an endogenous methyl donor that is a L A J OLLA, CALIF. — The recall of mg of salicin over a 2-week period, West- bo arm demonstrated superiority of naturally occurring product of the reac- Vioxx and safety warnings about Cele- ern Ontario and McMaster Universities phytodolor; six trials with a comparison tion between methionine and adenosine brex and Bextra created “a very insecure Osteoarthritis Index (WOMAC) pain group showed no benefit of phytodolor triphosphate (ATP). It is postulated to time for pain management,” Robert scores were reduced 40%, compared with over NSAIDs. have anti-inflammatory effects through Bonakdar, M.D., said at a meeting on nat- a 16% reduction among those on placebo. One trial found a dose response to dou- inhibition of tumor necrosis factor–α and ural supplements in evidence-based prac- At 2 weeks, the anal- ble-strength phytodo- upregulation of proteoglycan synthesis tice sponsored by the Scripps Clinic. gesic effect from wil- ‘People with higher pain lor vs. regular dosing and secretion into chondrocytes. SAMe But well before concern surfaced about low bark was as- at 2 weeks. also appears to have a serotonergic effect the safety of those drugs, patients with in- sessed to be about intensity and duration, and The typical dose in that may support its pain-modulating abil- flammatory disease increasingly began to 40% of that from those with a greater degree trials is 30 drops of ities. seek care from providers of complemen- high-dose NSAIDs. standardized extract In a metaanalysis of 11 osteoarthritis tri- tary and alternative medicine (CAM) be- “There is a dose- of self-care, are going to t.i.d. als, SAMe appeared to be as effective as cause they were dissatisfied with tradi- response relation- end up in more CAM Ǡ Devil’s claw NSAIDs in reducing pain and improving tional care results. ship,” Dr. Bonakdar (Harpagophytum functionality with fewer adverse effects “They thank their doctor for the said at the meeting, offices.’ procumbens). This than NSAIDS (J. Fam. Pract. 2002;51:425- NSAIDs, for the advice, for [the referral to] cosponsored by the South African plant is 30). SAMe is typically initiated in the 200- physical therapy, but they still have pain,” University of California, San Diego. A used for arthritis, myalgia, and as an ex- to 400-mg range and titrated to between said Dr. Bonakdar, director of pain man- randomized, double-blind placebo-con- ternal ointment for burns or sores. Its ac- 600 and 1,200 mg with caution regarding agement at the Scripps Center for Inte- trolled trial of 210 patients with low back tive ingredients are harpagoside and β- its serotonergic effects. grative Medicine, La Jolla, Calif. “Also, pain who took 120 mg or 240 mg salicin sitosterol. Other natural supplements such as gin- people with higher pain intensity and du- demonstrated complete relief from pain in There have been four double-blind, ger (Zingiber officinale), boswellia (Boswellia ration, and those with a greater degree of 21% and 39% of patients, respectively placebo-controlled trials involving 50-197 serrata), turmeric (Curcuma longa), and es- self-care, are going to end up in more (Am. J. Med. 2000;109:9-14). patients with osteoarthritis and low back sential fatty acids have also demonstrated CAM offices.” Only 6% of patients in the placebo pain. Patients were treated for 3-8 weeks anti-inflammatory activity in preliminary He discussed the following natural sup- group reported complete relief from pain. with 50-100 mg harpagosides/iridoid con- basic research or human trials. While these plements, which have been found useful in The dosage used in trials varies, but it is tent of 1.5%-3% (the typical dose in trials). and other natural supplements have been treating pain associated with inflammato- typically standardized to 240 g salicin/day. The treatments significantly improved documented for the treatment of pain, Dr. ry disease: Ǡ Phytodolor. Available since 1963, this the pain level and joint mobility in study Bonakdar emphasized that “further well- Ǡ Willow bark (Salix spp.). This agent patented supplement is from Germany. It participants. Side effects have included done trials are required to advance un- contains multiple constituents including contains 1 mg salicin/mL, Populus tremu- mild and infrequent GI symptoms (BMC derstanding.” ■ Low-Dose Combos Top High- Just 45% of Pain Patients Dose Monotherapy for Sciatica Take OxyContin as Prescribed BY TIMOTHY F. KIRN more dose-finding studies are needed. BY BETSY BATES pliant if the level of OxyContin in his or Sacramento Bureau In a report on two combined studies in- Los Angeles Bureau her urine was within three standard de- volving 1,405 patients with low back or viations of the mean. Interestingly, about S NOWMASS, COLO. — Sciatica and neck pain, participants were randomly as- PALM S PRINGS, CALIF. — Just 45% 15% of patients prescribed OxyContin low back pain respond best to low doses signed to take the muscle relaxant cy- of prescriptions for the opiate OxyCon- had none of the drug in their urine. of medications used in combination as op- clobenzaprine or placebo. Dr. Borenstein tin (oxycodone HCl controlled release) At the same time, many patients being posed to high-dose monotherapy, David G. noted that the cyclobenzaprine outper- are taken as directed by patients being treated with alternative pain drugs in the Borenstein, M.D., said at a symposium formed placebo in three primary, patient- treated for nonmalignant pain, according clinics had OxyContin in their urine, sponsored by the American College of rated end points: relief from pain at the to a study of urine samples from ap- suggesting that “most of the diversion Rheumatology. start of the day, assessment of medication proximately 5% of the nation’s outpa- was patient to patient,” Dr. Kell said. There are no magic bullets. Instead, “it’s helpfulness, and clinical global impression tient pain clinics. “There is an incredible amount of di- trial and error and seeing what works with of change. Fully 40% of the drug was recycled version on the street [as well]. We tend a patient,” said Dr. Borenstein, a textbook Interestingly, when the researchers among other patients being treated for to be in denial,” he added. author and researcher who practices in a looked at three doses—2.5 mg, 5 mg, and pain in 264 clinics whose combined case- Funding for Dr. Kell’s study was pro- rheumatology group in Washington. 10 mg—each taken three times daily, they loads exceeded 33,000 patients, Michael vided by UD Testing Inc., a Marco Island, According to prescribing patterns, it ap- found that all the doses were more effec- Kell, M.D., of the Labyrinth Institute of Fla., company that uses Dr. Kell’s soft- pears that muscle relaxants are among tive than placebo. The 5-mg dose was no Smyrna, Ga., reported at the annual ware to monitor patient compliance with the most effective medications for back less effective than the 10-mg dose and was meeting of the American Academy of prescription medicine. pain, but they’re more effective when used less likely to cause sedation, Dr. Borenstein Pain Medicine. Another study presented at the meet- in combination with other medications. said (Clin. Ther. 2003;25:1056-73). Another 15% of OxyContin prescrip- ing described very preliminary results In a telephone survey of patients with Future strategies for treating low back tions were diverted to the black market, from a novel oxycodone drug formula- acute low back pain contacted 1 week af- pain may involve biologics such as inflix- said Dr. Kell, who was chosen to present tion called Remoxy. The formulation de- ter an office visit, the best outcomes ap- imab, Dr. Borenstein said. his poster in an oral format at the meet- livers a long-acting dose of the opiate in peared to be associated with a combina- Yet to be published open-label trials of ing. Dr. Kell, a toxicologist, collected his a gel cap designed to be impervious to ef- tion treatment using a muscle relaxant and infliximab, conducted in Finland, have data using software technology that in- forts to extract the full dose to achieve a an NSAID together. Other respondents shown significant efficacy within hours of terprets highly specific urinalysis results “spike” effect by crushing, freezing, heat- were taking no medication, or opioids, ac- patients’ receiving a single injection, com- that control for urine concentration and ing, or dissolving it in various substances. etaminophen, and muscle relaxants alone pared with controls that were given sham acidity and patient body mass index Current formulations of the drug can (Spine 1998;23:607-14). injections of saline. (BMI). be manipulated in this way, adding to Dr. Borenstein said the survey findings Yet the only double-blinded, controlled The urine from 55% of approximate- abuse and diversion. are consistent with his own clinical expe- trial reported to date found no benefit rel- ly 11,000 patients prescribed OxyContin Plasma concentrations were marked- rience using combination regimens, ative to placebo. The lack of efficacy either contained more of the drug, or ly lower in 20 subjects who took Remoxy which he said can minimize side effects seen in this unpublished trial may have less, than what would be expected based after it had been tampered with, com- and have a synergistic effect.
Load more

Recommended publications
  • Table S1: Sensitivity, Specificity, PPV, NPV, and F1 Score of NLP Vs. ICD for Identification of Symptoms for (A) Biome Developm
    Table S1: Sensitivity, specificity, PPV, NPV, and F1 score of NLP vs. ICD for identification of symptoms for (A) BioMe development cohort; (B) BioMe validation cohort; (C) MIMIC-III; (D) 1 year of notes from patients in BioMe calculated using manual chart review. A) Fatigue Nausea and/or vomiting Anxiety Depression NLP (95% ICD (95% CI) P NLP (95% CI) ICD (95% CI) P NLP (95% CI) ICD (95% CI) P NLP (95% CI) ICD (95% CI) P CI) 0.99 (0.93- 0.59 (0.43- <0.00 0.25 (0.12- <0.00 <0.00 0.54 (0.33- Sensitivity 0.99 (0.9 – 1) 0.98 (0.88 -1) 0.3 (0.15-0.5) 0.85 (0.65-96) 0.02 1) 0.73) 1 0.42) 1 1 0.73) 0.57 (0.29- 0.9 (0.68- Specificity 0.89 (0.4-1) 0.75 (0.19-1) 0.68 0.97 (0.77-1) 0.03 0.98 (0.83-1) 0.22 0.81 (0.53-0.9) 0.96 (0.79-1) 0.06 0.82) 0.99) 0.99 (0.92- 0.86 (0.71- 0.94 (0.79- 0.79 (0.59- PPV 0.96 (0.82-1) 0.3 0.95 (0.66-1) 0.02 0.95 (0.66-1) 0.16 0.93 (0.68-1) 0.12 1) 0.95) 0.99) 0.92) 0.13 (0.03- <0.00 0.49 (0.33- <0.00 0.66 (0.48- NPV 0.89 (0.4-1) 0.007 0.94 (0.63-1) 0.34 (0.2-0.51) 0.97 (0.81-1) 0.86 (0.6-0.95) 0.04 0.35) 1 0.65) 1 0.81) <0.00 <0.00 <0.00 F1 Score 0.99 0.83 0.88 0.57 0.95 0.63 0.82 0.79 0.002 1 1 1 Itching Cramp Pain NLP (95% ICD (95% CI) P NLP (95% CI) ICD (95% CI) P NLP (95% CI) ICD (95% CI) P CI) 0.98 (0.86- 0.24 (0.09- <0.00 0.09 (0.01- <0.00 0.52 (0.37- <0.00 Sensitivity 0.98 (0.85-1) 0.99 (0.93-1) 1) 0.45) 1 0.29) 1 0.66) 1 0.89 (0.72- 0.5 (0.37- Specificity 0.96 (0.8-1) 0.98 (0.86-1) 0.68 0.98 (0.88-1) 0.18 0.5 (0-1) 1 0.98) 0.66) 0.88 (0.69- PPV 0.96 (0.8-1) 0.8 (0.54-1) 0.32 0.8 (0.16-1) 0.22 0.99 (0.93-1) 0.98 (0.87-1) NA* 0.97) 0.98 (0.85- 0.57 (0.41- <0.00 0.58 (0.43- <0.00 NPV 0.98 (0.86-1) 0.5 (0-1) 0.02 (0-0.08) NA* 1) 0.72) 1 0.72) 1 <0.00 <0.00 <0.00 F1 Score 0.97 0.56 0.91 0.28 0.99 0.68 1 1 1 *Denotes 95% confidence intervals and P values that could not be calculated due to insufficient cells in 2x2 tables.
    [Show full text]
  • The Role of Organic Small Molecules in Pain Management
    molecules Review The Role of Organic Small Molecules in Pain Management Sebastián A. Cuesta and Lorena Meneses * Laboratorio de Química Computacional, Facultad de Ciencias Exactas y Naturales, Escuela de Ciencias Químicas, Pontificia Universidad Católica del Ecuador, Av. 12 de Octubre 1076 Apartado, Quito 17-01-2184, Ecuador; [email protected] * Correspondence: [email protected]; Tel.: +593-2-2991700 (ext. 1854) Abstract: In this review, a timeline starting at the willow bark and ending in the latest discoveries of analgesic and anti-inflammatory drugs will be discussed. Furthermore, the chemical features of the different small organic molecules that have been used in pain management will be studied. Then, the mechanism of different types of pain will be assessed, including neuropathic pain, inflammatory pain, and the relationship found between oxidative stress and pain. This will include obtaining insights into the cyclooxygenase action mechanism of nonsteroidal anti-inflammatory drugs (NSAID) such as ibuprofen and etoricoxib and the structural difference between the two cyclooxygenase isoforms leading to a selective inhibition, the action mechanism of pregabalin and its use in chronic neuropathic pain, new theories and studies on the analgesic action mechanism of paracetamol and how changes in its structure can lead to better characteristics of this drug, and cannabinoid action mechanism in managing pain through a cannabinoid receptor mechanism. Finally, an overview of the different approaches science is taking to develop more efficient molecules for pain treatment will be presented. Keywords: anti-inflammatory drugs; QSAR; pain management; cyclooxygenase; multitarget drug; Citation: Cuesta, S.A.; Meneses, L. cannabinoid; neuropathic pain The Role of Organic Small Molecules in Pain Management.
    [Show full text]
  • NINDS Custom Collection II
    ACACETIN ACEBUTOLOL HYDROCHLORIDE ACECLIDINE HYDROCHLORIDE ACEMETACIN ACETAMINOPHEN ACETAMINOSALOL ACETANILIDE ACETARSOL ACETAZOLAMIDE ACETOHYDROXAMIC ACID ACETRIAZOIC ACID ACETYL TYROSINE ETHYL ESTER ACETYLCARNITINE ACETYLCHOLINE ACETYLCYSTEINE ACETYLGLUCOSAMINE ACETYLGLUTAMIC ACID ACETYL-L-LEUCINE ACETYLPHENYLALANINE ACETYLSEROTONIN ACETYLTRYPTOPHAN ACEXAMIC ACID ACIVICIN ACLACINOMYCIN A1 ACONITINE ACRIFLAVINIUM HYDROCHLORIDE ACRISORCIN ACTINONIN ACYCLOVIR ADENOSINE PHOSPHATE ADENOSINE ADRENALINE BITARTRATE AESCULIN AJMALINE AKLAVINE HYDROCHLORIDE ALANYL-dl-LEUCINE ALANYL-dl-PHENYLALANINE ALAPROCLATE ALBENDAZOLE ALBUTEROL ALEXIDINE HYDROCHLORIDE ALLANTOIN ALLOPURINOL ALMOTRIPTAN ALOIN ALPRENOLOL ALTRETAMINE ALVERINE CITRATE AMANTADINE HYDROCHLORIDE AMBROXOL HYDROCHLORIDE AMCINONIDE AMIKACIN SULFATE AMILORIDE HYDROCHLORIDE 3-AMINOBENZAMIDE gamma-AMINOBUTYRIC ACID AMINOCAPROIC ACID N- (2-AMINOETHYL)-4-CHLOROBENZAMIDE (RO-16-6491) AMINOGLUTETHIMIDE AMINOHIPPURIC ACID AMINOHYDROXYBUTYRIC ACID AMINOLEVULINIC ACID HYDROCHLORIDE AMINOPHENAZONE 3-AMINOPROPANESULPHONIC ACID AMINOPYRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE AMINOTHIAZOLE AMIODARONE HYDROCHLORIDE AMIPRILOSE AMITRIPTYLINE HYDROCHLORIDE AMLODIPINE BESYLATE AMODIAQUINE DIHYDROCHLORIDE AMOXEPINE AMOXICILLIN AMPICILLIN SODIUM AMPROLIUM AMRINONE AMYGDALIN ANABASAMINE HYDROCHLORIDE ANABASINE HYDROCHLORIDE ANCITABINE HYDROCHLORIDE ANDROSTERONE SODIUM SULFATE ANIRACETAM ANISINDIONE ANISODAMINE ANISOMYCIN ANTAZOLINE PHOSPHATE ANTHRALIN ANTIMYCIN A (A1 shown) ANTIPYRINE APHYLLIC
    [Show full text]
  • SOME NEW DRUGS in the TREATMENT of RHEUMATIC FEVER by M
    Postgrad Med J: first published as 10.1136/pgmj.28.317.179 on 1 March 1952. Downloaded from I79 SOME NEW DRUGS IN THE TREATMENT OF RHEUMATIC FEVER By M. J. H. SMITH, M.PHARM., PH.D., F.R.I.C. Department of Chemical Pathology, King's College Hospital Medical School, London Introduction every 4 to 8 hours. Symptoms such as dizziness, The usefulness of salicylates in rheumatic fever drowsiness and nausea developed in a small pro- is unquestioned, though their undesirable side- portion of the subjects, but in no instance were effects on the gastro-intestinal tract and on the these side-effects serious. The substance differed special senses are a drawback in prolonged therapy. from salicylic acid in producing a depression of Attempts to find allied substances with a greater the central nervous system in laboratory animals safety margin have been made and three com- and a decrease in the prothrombin time in man. pounds, salicylamide, sodium gentisate and The favourable clinical reports have led to the y-resorcylic acid, have recently been introduced. proposal that a large well-controlled trial should The treatment of rheumatic fever with ACTH be made.6 and cortisone has been the subject of a number of general reviews1' 2 and will not be discussed in the Gentisic Acid (2: 5-dihydroxybenzoic acid) present article. The cost and scarcity of these COOH by copyright. materials have stimulated a search for simpler compounds with a similar physiological action and a cinchoninic acid derivative (HPC) for which an ACTH-like activity is claimed, has been tried \AOH clinically in acute rheumatic fever.
    [Show full text]
  • Drug Name Plate Number Well Location % Inhibition, Screen Axitinib 1 1 20 Gefitinib (ZD1839) 1 2 70 Sorafenib Tosylate 1 3 21 Cr
    Drug Name Plate Number Well Location % Inhibition, Screen Axitinib 1 1 20 Gefitinib (ZD1839) 1 2 70 Sorafenib Tosylate 1 3 21 Crizotinib (PF-02341066) 1 4 55 Docetaxel 1 5 98 Anastrozole 1 6 25 Cladribine 1 7 23 Methotrexate 1 8 -187 Letrozole 1 9 65 Entecavir Hydrate 1 10 48 Roxadustat (FG-4592) 1 11 19 Imatinib Mesylate (STI571) 1 12 0 Sunitinib Malate 1 13 34 Vismodegib (GDC-0449) 1 14 64 Paclitaxel 1 15 89 Aprepitant 1 16 94 Decitabine 1 17 -79 Bendamustine HCl 1 18 19 Temozolomide 1 19 -111 Nepafenac 1 20 24 Nintedanib (BIBF 1120) 1 21 -43 Lapatinib (GW-572016) Ditosylate 1 22 88 Temsirolimus (CCI-779, NSC 683864) 1 23 96 Belinostat (PXD101) 1 24 46 Capecitabine 1 25 19 Bicalutamide 1 26 83 Dutasteride 1 27 68 Epirubicin HCl 1 28 -59 Tamoxifen 1 29 30 Rufinamide 1 30 96 Afatinib (BIBW2992) 1 31 -54 Lenalidomide (CC-5013) 1 32 19 Vorinostat (SAHA, MK0683) 1 33 38 Rucaparib (AG-014699,PF-01367338) phosphate1 34 14 Lenvatinib (E7080) 1 35 80 Fulvestrant 1 36 76 Melatonin 1 37 15 Etoposide 1 38 -69 Vincristine sulfate 1 39 61 Posaconazole 1 40 97 Bortezomib (PS-341) 1 41 71 Panobinostat (LBH589) 1 42 41 Entinostat (MS-275) 1 43 26 Cabozantinib (XL184, BMS-907351) 1 44 79 Valproic acid sodium salt (Sodium valproate) 1 45 7 Raltitrexed 1 46 39 Bisoprolol fumarate 1 47 -23 Raloxifene HCl 1 48 97 Agomelatine 1 49 35 Prasugrel 1 50 -24 Bosutinib (SKI-606) 1 51 85 Nilotinib (AMN-107) 1 52 99 Enzastaurin (LY317615) 1 53 -12 Everolimus (RAD001) 1 54 94 Regorafenib (BAY 73-4506) 1 55 24 Thalidomide 1 56 40 Tivozanib (AV-951) 1 57 86 Fludarabine
    [Show full text]
  • Comparative Anti-Inflammatory Effects of Salix Cortex Extracts And
    International Journal of Molecular Sciences Article Comparative Anti-Inflammatory Effects of Salix Cortex Extracts and Acetylsalicylic Acid in SARS-CoV-2 Peptide and LPS-Activated Human In Vitro Systems Nguyen Phan Khoi Le 1 , Corinna Herz 1, João Victor Dutra Gomes 1 , Nadja Förster 2, Kyriaki Antoniadou 3, Verena Karolin Mittermeier-Kleßinger 3, Inga Mewis 2 , Corinna Dawid 3 , Christian Ulrichs 2 and Evelyn Lamy 1,* 1 Molecular Preventive Medicine, University Medical Center and Faculty of Medicine, University of Freiburg, 79108 Freiburg, Germany; [email protected] (N.P.K.L.); [email protected] (C.H.); [email protected] (J.V.D.G.) 2 Division Urban Plant Ecophysiology, Humboldt-Universität zu Berlin, 14195 Berlin, Germany; [email protected] (N.F.); [email protected] (I.M.); [email protected] (C.U.) 3 Food Chemistry and Molecular Sensory Science, Technical University of Munich, Lise-Meitner-Str. 34, 85354 Freising, Germany; [email protected] (K.A.); [email protected] (V.K.M.-K.); [email protected] (C.D.) * Correspondence: [email protected]; Tel.: +49-761-270-82150 Abstract: The usefulness of anti-inflammatory drugs as an adjunct therapy to improve outcomes in COVID-19 patients is intensely discussed. Willow bark (Salix cortex) has been used for centuries Citation: Le, N.P.K.; Herz, C.; Gomes, to relieve pain, inflammation, and fever. Its main active ingredient, salicin, is metabolized in the J.V.D.; Förster, N.; Antoniadou, K.; human body into salicylic acid, the precursor of the commonly used pain drug acetylsalicylic Mittermeier-Kleßinger, V.K.; Mewis, acid (ASA).
    [Show full text]
  • A Double-Blind Controlled Crossover Study to Investigate the Efficacy Of
    Complementary Therapies in Medicine 44 (2019) 102–109 Contents lists available at ScienceDirect Complementary Therapies in Medicine journal homepage: www.elsevier.com/locate/ctim A double-blind controlled crossover study to investigate the efficacy of salix extract on primary dysmenorrhea T ⁎ Z. Raisi Dehkordia,M.Rafieian-kopaeib, F.S. Hosseini-Baharanchic,d, a Department of Midwifery, School of Nursing and Midwifery, Shahrekord University of Medical Sciences, Shahrekord, Iran b Medical Plants Research Center, Shahrekord University of Medical Science, Shahrekord, Iran c Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran d Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran ARTICLE INFO ABSTRACT Keywords: Objectives: Primary dysmenorrhea in the absence of pelvic pathology is a common gynecologic disorder affecting Dysmenorrhea the quality of life of women of reproductive age. This study evaluates the effect of salix extract on primary Salix dysmenorrhea. Mefenamic acid Design: This study was a randomized crossover clinical trial. Complementary therapies Setting: The study population included 96 female students with level two or three of primary dysmenorrhea: 48 Cross-over studies students in the treatment group (sequence I) followed by control (sequence II) and 48 students in control group (sequence I) followed by treatment (sequence II). Interventions: The intervention was salix capsule (400 mg daily) and the active control was mefenamic acid capsule (750 mg daily) as. Main outcomes: Pain intensity, measured by the visual analog scale (VAS), amount of bleeding, and severity of dysmenorrhea symptoms were outcomes. Generalized estimating equations were used for data analysis. Results: The demographic and menstrual characteristics of the students were homogenous between the groups.
    [Show full text]
  • (Aspirin) in Rheumatoid Arthritis
    Br. J. clin. Pharmac. (1989), 27, 607-611 Comparative analgesic and anti-inflammatory properties of sodium salicylate and acetylsalicylic acid (aspirin) in rheumatoid arthritis SALLY J. PRESTON, M. H. ARNOLD, ELAINE M. BELLER, P. M. BROOKS & W. WATSON BUCHANAN Florance and Cope Professorial Department of Rheumatology and Sutton Rheumatism Research Laboratory, Department of Rheumatology, University of Sydney, Royal North Shore Hospital, St Leonards 2065, New South Wales, Australia 1 Enteric coated sodium salicylate 4.8 g daily was compared with the same dose of enteric coated aspirin in 18 patients with rheumatoid arthritis. 2 After an initial washout period lasting 3 days, patients were randomly allocated to treatment with sodium salicylate or aspirin. After 2 weeks the two treatments were crossed over. 3 Pain relief, reduction in articular index of joint tenderness, increase in grip strength, decrease in digital joint circumference and patients' assessment showed significant im- provement with both treatments compared with the washout period. No significant differ- ences were found between the two therapies. 4 No correlation was found in the degree of improvement in any of the clinical outcomes and the salicylate concentrations at steady state. Keywords aspirin sodium salicylate non-acetylated salicylates clinical trial rheumatoid arthritis 'Sodium salicylate does not appear to be as in particular sodium salicylate (Lasagna, 1960; potent as aspirin as an antipyretic or analgesic Levy, 1965; Calabro & Paulus, 1970; Champion . but has not been compared under con- et al., 1975). Sodium salicylate, however, has trolled conditions to aspirin in the management been shown in clinical therapeutic trials in of inflammatory disorders' rheumatoid arthritis to be as equally efficacious as other nonsteroidal anti-inflammatory agents Stephen L.
    [Show full text]
  • Biochemistry. in the Article “An Erp60-Like Protein from the Filarial
    9966 Corrections Proc. Natl. Acad. Sci. USA 96 (1999) Biochemistry. In the article “An Erp60-like protein from the Immunology. In the article “Bacteria-induced neo-biosynthe- filarial parasite Dirofilaria immitis has both transglutaminase sis, stabilization, and surface expression of functional class I and protein disulfide isomerase activity” by Ramaswamy molecules in mouse dendritic cells” by Maria Rescigno, Ste- Chandrashekar, Naotoshi Tsuji, Tony Morales, Victor Ozols, fania Citterio, Clotilde The`ry, Michael Rittig, Donata Meda- and Kapil Mehta, which appeared in number 2, January 20, glini, Gianni Pozzi, Sebastian Amigorena, and Paola Ricciardi- 1998, of Proc. Natl. Acad. Sci. USA (95, 531–536), the authors Castagnoli, which appeared in number 9, April 28, 1998, of inadvertently cited the wrong GenBank accession numbers for Proc. Natl. Acad. Sci. USA (95, 5229–5234), the following four database sequences in the figure legend of a dendrogram corrections should be noted. The changes to references 33 and (Fig. 3b) on page 534. The correct accession numbers are 34 are in bold type. shown in the table below. 33. Medaglini, D., Rush, C. M., Sestini, P. & Pozzi, G. C. (1997) Vaccine 15, 1330–1337. Sequence ID Accession no. as published Correct accession no. 34. Rittig, M. G., Kuhn, K., Dechant, C. A., Gaukler, A., Modolell, RATPDI P54001 P04785 M., Ricciardi-Castagnoli, P., Krause, A. & Burmester, G. R. HUMPDI P55059 P07237 (1996) Dev. Comp. Immunol. 20, 393–406. CHICKPDI P16924 P09102 CEPDI Q10576 U95074 Pharmacology. The article “Nonsteroid drug selectives for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associ- Biophysics. In the article “Characterization of lipid bilayer ated with human gastrointestinal toxicity: A full in vitro phases by confocal microscopy and fluorescence correlation analysis” by Timothy D.
    [Show full text]
  • Composition for Use in Treating and Preventing Inflammation Related Disorder
    (19) TZZ 54¥¥7A_T (11) EP 2 543 357 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 09.01.2013 Bulletin 2013/02 A61K 9/00 (2006.01) A61K 47/36 (2006.01) (21) Application number: 11173000.8 (22) Date of filing: 07.07.2011 (84) Designated Contracting States: (72) Inventor: Lin, Shyh-Shyan AL AT BE BG CH CY CZ DE DK EE ES FI FR GB Taipei (TW) GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (74) Representative: Becker Kurig Straus Designated Extension States: Bavariastrasse 7 BA ME 80336 München (DE) (71) Applicant: Holy Stone Healthcare Co.,Ltd. Taipei City (TW) (54) Composition for use in treating and preventing inflammation related disorder (57) The presentinvention isrelated to ause fortreat- ease, coeliac disease, conjunctivitis, otitis, allergic rhin- ing and preventing inflammation related disorder of a itis, gingivitis, aphthous ulcer, bronchitis, gastroesopha- composition containing a drug and hyaluronic acid (HA) geal reflux disease (GERD), esophagitis, gastritis, en- or HA mixture, whereas the HA or the HA mixture as a teritis, peptic ulcer, inflammatory bowel disease (IBD), delivery vehicle can be a formulation including at least Crohn’s Disease, irritable bowel syndrome (IBS), intes- two HAs having different average molecular weights. The tinal inflammation or allergy, urethritis, cystitis, vaginitis, composition has been demonstrated to be capable of proctitis, eosinophilic gastroenteritis, or rheumatoid ar- reducing the therapeutic dose of a drug on the treatment thritis. and prevention of inflammation related disorders is acute inflammatory disease, chronic obstructed pulmonary dis- EP 2 543 357 A1 Printed by Jouve, 75001 PARIS (FR) 1 EP 2 543 357 A1 2 Description alleviate pain by counteracting the cyclooxygenase (COX) enzyme.
    [Show full text]
  • 2 12/ 35 74Al
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 22 March 2012 (22.03.2012) 2 12/ 35 74 Al (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 9/16 (2006.01) A61K 9/51 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 9/14 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/EP201 1/065959 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (22) International Filing Date: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 14 September 201 1 (14.09.201 1) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, (25) Filing Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, (26) Publication Language: English TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 61/382,653 14 September 2010 (14.09.2010) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant (for all designated States except US): GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, NANOLOGICA AB [SE/SE]; P.O Box 8182, S-104 20 ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, Stockholm (SE).
    [Show full text]
  • Phenolic Compounds in Trees and Shrubs of Central Europe
    applied sciences Review Phenolic Compounds in Trees and Shrubs of Central Europe Lidia Szwajkowska-Michałek 1,*, Anna Przybylska-Balcerek 1 , Tomasz Rogozi ´nski 2 and Kinga Stuper-Szablewska 1 1 Department of Chemistry, Faculty of Forestry and Wood Technology, Pozna´nUniversity of Life Sciences ul. Wojska Polskiego 75, 60-625 Pozna´n,Poland; [email protected] (A.P.-B.); [email protected] (K.S.-S.) 2 Department of Furniture Design, Faculty of Forestry and Wood Technology, Pozna´nUniversity of Life Sciences ul. Wojska Polskiego 38/42, 60-627 Pozna´n,Poland; [email protected] * Correspondence: [email protected]; Tel.: +48-61-848-78-43 Received: 1 September 2020; Accepted: 30 September 2020; Published: 2 October 2020 Abstract: Plants produce specific structures constituting barriers, hindering the penetration of pathogens, while they also produce substances inhibiting pathogen growth. These compounds are secondary metabolites, such as phenolics, terpenoids, sesquiterpenoids, resins, tannins and alkaloids. Bioactive compounds are secondary metabolites from trees and shrubs and are used in medicine, herbal medicine and cosmetology. To date, fruits and flowers of exotic trees and shrubs have been primarily used as sources of bioactive compounds. In turn, the search for new sources of bioactive compounds is currently focused on native plant species due to their availability. The application of such raw materials needs to be based on knowledge of their chemical composition, particularly health-promoting or therapeutic compounds. Research conducted to date on European trees and shrubs has been scarce. This paper presents the results of literature studies conducted to systematise the knowledge on phenolic compounds found in trees and shrubs native to central Europe.
    [Show full text]