Brain and Mind Centre

Annual Report 2017-18

Contact us sydney.edu.au/brain-mind +61 2 9351 0774 Forest Stewardship Council (FSC®) is a globally recognised certification overseeing all fibre sourcing standards. This provides guarantees for the consumer that products are made of woodchips from well-managed forests and other controlled sources with strict environmental, economical and social standards. Contents Overview ��������������������������������������������������������� 2 Sydney Neuroimmunology ��������������������������� 49 Key research themes �������������������������������������������� 2 Our core business �����������������������������������������������50 - Research areas �����������������������������������������������������51 Welcome ���������������������������������������������������������4 Highlights ��������������������������������������������������������������� 52 Co-Directors’ message ���������������������������������������� 4 Publications ����������������������������������������������������������53 Message from the University ������������������������������� 6 - Message from Teresa Anderson ������������������������� 7 Sleep and Circadian Biology ������������������������ 57 - Our core business �����������������������������������������������58 Child Neurodevelopment Current research �������������������������������������������������59 and Mental Health ������������������������������������������ 8 Highlights ���������������������������������������������������������������60 Our core business ������������������������������������������������� 9 2019 and beyond ���������������������������������������������������61 A preventative, holistic Key publications ��������������������������������������������������� 62 and supportive approach - to child mental health ���������������������������������������� 10 Computational Neuroscience ���������������������64 Our team �����������������������������������������������������������������11 Our core business �����������������������������������������������65 Highlights ����������������������������������������������������������������12 Highlights ���������������������������������������������������������������66 - Key publications ���������������������������������������������������68

 - Youth Mental Health ��������������������������������������14 Our core business ������������������������������������������������15 Technical Facilities ��������������������������������������� 70 Key projects and clinical trials ���������������������������16 Highlights ��������������������������������������������������������������� 73 Highlights ����������������������������������������������������������������18 Key publications ��������������������������������������������������� 74 Key publications ���������������������������������������������������20 Neuropathology ��������������������������������������������������� 75 - Highlights ��������������������������������������������������������������� 76 Psychology Clinic ����������������������������������������� 23 Key publications ��������������������������������������������������� 77 Our core business ����������������������������������������������� 24 Microscopy ����������������������������������������������������������� 78 Highlights ��������������������������������������������������������������� 25 Neurology Laboratory ���������������������������������������� 79 Key publications ��������������������������������������������������� 26 Key publications ���������������������������������������������������80 - - Child Behaviour Lambert Initiative ������������������������������������������81 Research Clinic �������������������������������������������� 27 Our core business ����������������������������������������������� 82 Our core business ����������������������������������������������� 28 Highlights ���������������������������������������������������������������83 Grants / funding ��������������������������������������������������29 Grants awarded ��������������������������������������������������� 87 Key publications ���������������������������������������������������30 Key publications ��������������������������������������������������� 87 - - Gambling Treatment Brain and Mind Centre ��������������������������������� 88 and Research Clinic ������������������������������������� 32 Our donors �����������������������������������������������������������88 Our core business �����������������������������������������������33 Supporting research �������������������������������������������89 Research ���������������������������������������������������������������34 Supporting early-career Clinical practice ���������������������������������������������������35 researchers ����������������������������������������������������������90

 Cultural outreach and education ���������������������36 Thanks to our donors ������������������������������������������91 Industry engagement ������������������������������������������ 37 Our teams �������������������������������������������������������������92 Highlights ���������������������������������������������������������������38 Key publications ���������������������������������������������������39 - ForeFront Ageing and Neurodegeneration �������������������������������40 Our core business ������������������������������������������������41 ForeFront research teams ���������������������������������42 Highlights ���������������������������������������������������������������44 Key publications ���������������������������������������������������46 Page 1 Overview Key research themes

At the University of Sydney’s Brain and Mind Centre, our sydney.edu.au/brain-mind teams partner across borders and disciplines in pursuit of a common goal: to develop better treatments for conditions of the brain and mind, and improve health outcomes now and for future generations.

Our multidisciplinary research teams are at Our visionary research teams span the forefront of brain and mind sciences. We preclinical, clinical and translational work to find answers to some of the world’s research. Our work extends beyond most pressing health concerns, including: laboratories and clinics to our strong −− childhood development partnerships with industry, government, the and behaviour disorders community, other healthcare providers and diverse branches of academia to make a real −− youth mental health and addiction difference to people’s lives. −− ageing and neurodegeneration. Brain and Mind Centre Annual Report 2017-18 The University of Sydney

Associate Professor Muireann Irish

Page 2 and PhD candidate Siddharth Ramanan Page 3 Key research themes Overview Welcome Co-Directors’ message

Welcome to the Brain and Mind Centre Annual Report, which celebrates our many achievements over the past two years. sydney.edu.au/brain-mind

2017–18 has been a period of growth The partnership will benefit people and exploration of new potential with a range of neurological for the Brain and Mind Centre. illnesses, including multiple Our collaborations, both across sclerosis and dementia. University of Sydney campuses, and with external partners such as Our transformative work would not Local Health Districts, government, be possible without philanthropy. In industry and community bodies, a climate where it has never been have led to the establishment more difficult to secure competitive of exciting new multidisciplinary grant funding, philanthropy has Professor Matthew Kiernan AM Co-Director, Discovery research teams. The unique allowed our innovative research and Translation perspective of these teams means to continue to thrive. In particular, we can combine cutting-edge private donations have supported research with safe and effective the appointment of a number of clinical approaches, this enables us leading researchers within the Brain to pioneer new systems of care for and Mind Centre. Following a $1.5 those affected by disorders of the million commitment from a private

Brain and Mind Centre Annual Report 2017-18 brain and mind. family, the Brain and Mind Centre has been able to establish a new The last two years have seen Chair in translational research. a focus on further developing 2018 saw the appointment of our strategic partnerships with Professor Cindy (Shin-Yi) Lin to Professor Ian Hickie AM this position, the Kam Ling Barbara Co-Director, Health and Policy industry. By working closely with a range of industry partners, the Lo Chair in Neurodegenerative Brain and Mind Centre has been Disorders. Professor Lin’s able to translate new technologies academic leadership will enable and research discoveries into the Centre to leverage its efforts innovations that benefit society and to develop novel diagnostic the economy. One such success biomarkers and lead clinical trials has come from our Computational of new therapies for a range of Neuroscience team. Itself a neurodegenerative disorders. unique collaboration between the Faculty of Medicine and Health Philanthropy has also been vital in and the Faculty of Engineering and the support of a future generation

The University of Sydney Rod Gilroy, Information Technology, the team of leaders in the brain and mind Chief Operating Officer Brain and Mind Centre has partnered with the Sydney sciences by funding early-career Neuroimaging Analysis Centre and research fellowships. Thanks to a I-MED Radiology Network on a very generous donation from the $2.36 million Cooperative Research Bluesand Foundation, Dr Eleanor Centre-Project to develop and Drummond has been appointed to commercialise algorithms to a three-year fellowship as Bluesand improve diagnostic neuroimaging. Fellow in Alzheimer’s Disease. Page 4 Dr Ramon Landin-Romero, the youth mental health. Together We hope you enjoy this publication Appenzeller Neuroscience Fellow with colleagues Professors Nadia and look forward to our in Alzheimer’s Disease, has been Badawi, Russell Dale and Joshua continued successes. similarly supported by Otto and Burns, Professor Guastella is Judy Appenzeller, who generously leading the newly established Child donated funding to establish a Neurodevelopment and Mental Welcome three-year fellowship at the Brain Health team at the Brain and Mind and Mind Centre. Centre, which is committed to Professor Matthew Kiernan AM identifying novel interventions to Co-Director, Discovery and Translation We also congratulate Professor address the significant health and Adam Guastella on his recent societal issues associated with child appointment to the role of Michael neurodevelopmental disorders and Crouch Chair in Child and Youth mental health. Mental Health. In this position, Professor Ian Hickie AM Co-Director, Health and Policy Professor Guastella will further The vast number of achievements build our partnerships with highlighted in this report, from Westmead Children’s Hospital, peer-reviewed publications and

Kids Research, the Cerebral Palsy grants to fellowships and awards, Alliance Research Institute and is a testament to the tireless work Nepean Blue Mountains Local of our researchers over the last Health District, providing academic two years. Rod Gilroy, leadership in the area of child and Chief Operating Officer Co-Directors’ message

L-R Professor Ian Hickie, Professor Matthew Kiernan and Rod Gilroy Page 5 Welcome Message from the University

The University of Sydney is home to a select number of pan‑university multidisciplinary initiatives which bring together

sydney.edu.au/brain-mind talented researchers across diverse disciplines to advance teaching and research objectives in a collaborative environment.

These initiatives create thought leads national policy development leadership, delivering research through sustained engagement excellence and education with Governments, those living opportunities in established and with mental illness [and] the developing areas of strength, across wider community, and it invests in all of our faculties. The initiatives new health system partnerships, have the remit of conducting emphasising innovative youth transformative and translational services and utilisation of research, ensuring a positive information technologies.” contribution to our society, while Professor Duncan Ivision Deputy Vice-Chancellor, Research providing invigorating and inspiring This is just one of the Centre’s University of Sydney opportunities for our academics accomplishments. We are thrilled and students. to present a summary of the important and ongoing work that Brain and Mind Centre Annual Report 2017-18 The Brain and Mind Centre is an they conducted throughout 2017 exemplar of these multidisciplinary and 2018. initiatives. In the Australian government’s 2018 and inaugural assessment of engagement and impact of Australian university research, the Brain and Mind Centre was recognised as having the highest possible level of societal Professor Duncan Ivison impact for their interdisciplinary Deputy Vice-Chancellor, Research Professor Laurent Rivory University of Sydney Pro Vice-Chancellor, Strategic approach to mental health care: Collaborations and Partnerships University of Sydney “[The Brain and Mind Centre] … has focused on developing new multidisciplinary models of mental health care – concentrating on children and young people – where The University of Sydney early intervention can have large Professor Laurent Rivory economic and social benefits over Pro-Vice-Chancellor, Research the long term. The impacts of University of Sydney these new models are personal and collective; assisting individuals to achieve their full potential, while growing the ‘mental wealth’ of the

Page 6 nation. The Brain and Mind Centre Welcome Message from Teresa Anderson

Our district has a strong tradition major priority for this partnership. of research excellence and we Sydney Local Health District, Sydney continue to be world leaders in Health Partners and the Brain and translational research, thanks to Mind Centre are investing heavily in our strong collaborations with the the people, information technology University of Sydney, our medical infrastructure and clinical platforms research institute partners as needed not only to test new well as the Northern Sydney and treatments (such as cannabidiols, Western Sydney Local Health ketamine, immunotherapies and Districts, and Sydney Children’s circadian-based behavioural and Teresa Anderson Chief Executive Hospital Network, as part of Sydney pharmacological treatments) Sydney Local Health District

Health Partners. in young people with complex Welcome depressive, bipolar or psychotic Following the recognition of Sydney disorders, but also new ways of Health Partners as a National delivering highly personalised Health and Medical Research and measurement-based care. Council Advanced Health Research This utilises the new IT platforms and Translation Centre in 2015, we developed by the Brain and Mind have been working closely with the Centre and the unique youth health Brain and Mind Centre on a number service partnerships that we have of key health priorities in mental developed (such as headspace health and neuroscience. and other new Commonwealth- supported intensive services). In particular, we continue to Together, we have very significantly lead the development of Sydney increased our capacity for further Neuroimmunology, a team of novel clinical trials and linked internationally renowned clinicians health services research that is and researchers from across the critical to national mental-health Sydney Health Partners network, policy developments. who are at the forefront of research into diseases of the brain and mind We look forward to continuing our that are associated with immune partnership with the Brain and Mind dysfunction. The partnership Centre into the future. will enable improved access to Teresa Anderson Message from Teresa Anderson specialist diagnostic immunology Chief Executive services for patients with suspected Sydney Local Health District neuroimmune disorders, as well as provide unprecedented opportunities to develop novel diagnostic biomarkers of disease and develop new and innovative treatments for some of the most debilitating neurological disorders.

The development of novel clinical trials, particularly in the area of youth mental health, is another Page 7

Child Neurodevelopment and Mental Health sydney.edu.au/brain-mind _

Enhancing children’s wellbeing to prevent problems later in life. Brain and Mind Centre Annual Report 2017-18 The University of Sydney Page 8

Child Neurodevelopment and Mental Health Our core business

Our team brings together world leaders of child clinical research to improve child neurodevelopment and mental wellbeing.

Neurodevelopmental disorders affect approximately one in 10 Australian children and include Autism Spectrum Disorder, Attention Deficit Hyperactivity Child Neurodevelopment and Mental Health Disorders, Cerebral Palsy and Tourette’s Syndrome. These disorders impact cognitive, social, and emotional development in the first years of life. Our clinical researchers specialise in developing innovative assessments and treatments that support child development and mental health. We also work to identify factors that contribute to vulnerability, resilience and well-being in children and their families. Our core business Page 9 Child Neurodevelopment and Mental Health A preventative, holistic and supportive approach to child mental health

−− delivering high-quality clinical trials using large, selected child cohorts and targeting the neurodevelopmental sydney.edu.au/brain-mind and mental health needs of children and families in order to inform best-practice care. −− population health linkage studies to inform high-quality surveillance data to advise evidence-based policy.

Through this approach, the team aims to identify and treat each child at the earliest possible time with the best possible approaches, in order to address the significant health and societal issues associated with child neurodevelopmental disorders and mental health.

The Child Neurodevelopment and Our team works with the community The team is focused on developing (families, professionals across an evidence-base to reduce the Brain and Mind Centre Annual Report 2017-18 Mental Health team are focused on childhood disorders of the disciplines and children) to improve impact of childhood adversity brain and mind. Our research aim assessment and early interventions that diminishes life potential, as is to address the developmental in child neurodevelopmental well as providing individuals and and emotional needs of the child disorders and mental health families with greater opportunities in collaboration with clinical broadly. This includes: to lead healthy, productive and services and industry. The team −− developing optimal fulfilling lives. focuses their work on cross-cutting assessment approaches platforms across the University of that address the needs of Sydney campuses at Westmead, children and their families. Nepean and Camperdown and −− using technology to improve in partnership with the Sydney client-centred care and Children’s Hospital Network communication between (Westmead and Randwick) and their researchers, clinicians and clinical services. families, as well as opportunities for larger research projects This network consists of the capitalising on data linkage. largest cohorts of children with The University of Sydney neurodevelopmental and mental −− identifying clinical and biological health needs nationally and markers (genomic, epigenomic, provides a landmark platform metabolomic, microbiomic, for developing new knowledge physiological and cognitive) and practices. to inform assessment and clinical decision making or as targets for new interventions. Page 10 Child Neurodevelopment and Mental Health Our team

Led by internationally regarded A multidisciplinary child psychologist and the Michael approach Crouch Chair in Child and Youth Mental Health, Professor Adam The team integrates high- Guastella; Paediatric Neurologist performing researchers across and Head of Kids Neuroscience multiple disciplines, including Centre at the Children’s imaging, neurochemistry, Hospital at Westmead, Professor genomics, biomechanics, Russell Dale; Chair of Cerebral psychology, neurology, psychiatry, Palsy – Cerebral Palsy Alliance, paediatrics, speech pathology, Professor Nadia Badawi; Paediatric and occupational therapy. It brings

epidemiologist and the Financial together the University of Sydney’s Child Neurodevelopment and Mental Health Markets Foundation for Children research leaders from multiple Chair in Translational Childhood Local Health Districts to form Medicine at Children’s Hospital partnerships that facilitate clinical at Westmead, Professor Natasha trials of behavioural therapies, Nassar; and Associate Dean and neuropsychological, genomic, Research (Health Sciences) and inflammatory and neurobiological NSW Director of the Paediatric interventions. Gait Analysis Service, Professor Joshua Burns, the team takes a novel, transdiagnostic approach to child neurodevelopment and mental health. Our team Page 11 Child Neurodevelopment and Mental Health Highlights

Appointment of Professor Adam Guastella to the new Crouch Chair in Child and sydney.edu.au/brain-mind Youth Mental Health At the end of 2018, the University of Sydney appointed Professor Adam Guastella as the Michael Crouch Chair in Child and Youth Mental Health. Leveraging generous philanthropic funding, the newly created position will provide academic leadership in the area of child and youth mental health, working collaboratively with leading researchers and the community across the Brain and Mind Centre, the Children’s Hospital at Westmead Clinical School and the Sydney Children’s Hospital Network.

Partnering with

Brain and Mind Centre Annual Report 2017-18 Cerebral Palsy Alliance The Cerebral Palsy Alliance Research Institute aims to prevent

and cure cerebral palsy as well Professor Adam Guastella as find innovative treatments and interventions. Their researchers work across disciplines to conduct cutting-edge research and translate research findings into practice. The Cerebral Palsy Alliance Research Institute are a key partner in the Child Neurodevelopment and Mental Health team. The University of Sydney Page 12 Patient spotlight Hayden’s story

Hayden was diagnosed with Autism Spectrum Disorder when he was two years old. His mother Christine spent years trying various therapies and medications, but nothing made a difference. Hayden was trapped in his own world, unable to communicate.

“He didn’t want to be in a group or Child Neurodevelopment and Mental Health participate,” Christine explains. “He wouldn’t even sit down in a circle. A small transition or change in activity would result in a tantrum. He didn’t trust me or anyone trying to help him.”

After contacting multiple paediatricians, Christine was directed to the Brain and Mind Centre where she learned of a new trial for autistic children involving oxytocin. This was a turning point in Hayden’s life. “It was the first time he was really able to engage and become aware he was not the only person in the room,” says Christine. “I had no idea Hayden was aware of his surroundings until he started saying things like, ‘Oh, I like that car’.”

The Brain and Mind Centre treatment enabled Hayden to make friends, sit quietly and learn new things at school. Recently, he even attended school camp for three nights. “The changes I saw from the trial completely changed the way Hayden engaged,” says Christine. “He wanted to be part of a group, he didn’t fight and his language and social skills improved.”

Hayden Page 13

Youth Mental Health _ sydney.edu.au/brain-mind

Transforming the mental health care of young people. Brain and Mind Centre Annual Report 2017-18 The University of Sydney Page 14

Youth Mental Health Our core business

The Youth Mental Health and Technology team puts young people at the centre of their own care. We partner with health services to develop innovative treatments for young people aged 12–30 with emerging mental health disorders.

A new way forward Our research focus There is a great need to transform the way in which We focus on three main streams of research: clinical care is delivered to young people with −− Clinical service development: continuously emerging mental health disorders such as anxiety, improving health services for young people Youth Mental Health depression, other mood disorders and psychosis. by systematically evaluating services. Specialised clinical assessment is required and −− Technology: optimising online environments treatment systems need to be much more customised to deliver services, track progress and provide to the individual’s unique needs. feedback to young people and their clinicians.

We aim to transform how clinical care is delivered to −− Clinical research: ongoing longitudinal patient young people with mental health issues. Rather than studies to develop and trial new interventions rely on broad diagnostic generalisations, we want to for complex mental health issues. see clinicians diagnose and treat young people in a way that caters to the individual needs of each person. Collaboration for better outcomes Our research program is heavily integrated with headspace Camperdown. headspace is the national youth mental health foundation, providing early intervention and mental health services to young people aged 12–25.

We are also collaborating with St. Vincent’s Private Hospital – USpace, Australia’s first private mental health service targeted to the needs of young adults aged 16–30, and Mind Plasticity, a private specialist practice consortium. Our core business

The integration of cutting-edge research with safe and effective clinical care enables us to quickly and effectively translate our research findings into different clinical services, facilitating continuous improvements to mental health services for the benefit of young people in Australia. Page 15 Youth Mental Health Key projects and clinical trials

Longitudinal cohort study

sydney.edu.au/brain-mind In time, this technology may be used as the The Brain and Mind Youth Cohort Study first point of contact in clinical care. The began in 2008. More than 10 years later, we Australian Government’s Department of have assessed more than 8000 individuals Health has provided funds to InnoWell for a with early phases of anxiety, mood or series of research trials, known as Project psychotic disorders. In partnership with St Synergy, running from 2017–2020, to test this Vincent’s Private Hospital – USpace, we are platform across different population groups, now also including inpatients. including young people.

From this cohort we have learned a lot Through the InnoWell Platform, specifically about long-term functional outcomes and InnoWell Care, young people can: observed that young people in need of −− complete real-time questionnaires care are led to services that either over- or and view their results immediately under-treat them; or, as their needs change, these young people find it difficult to transfer −− monitor their ongoing progress between services. −− choose, in collaboration with their clinician, treatment options These data suggest that more sophisticated tailored to their unique needs. treatment strategies may be required to achieve significant and sustained functional This seamless continuum of support from online services through to healthcare

Brain and Mind Centre Annual Report 2017-18 improvements. In order to address this problem, we are currently establishing a new providers offered by the Platform aims to longitudinal tracking study linked to a new facilitate young people’s access to the right clinical trial network, which will allow for care at the right time, thereby fundamentally personalised care at scale for young people. improving the system of care in Australia’s youth mental health services. Self-managed healthcare through The InnoWell Platform is currently being digital technology: Project Synergy implemented within 11 headspace locations We are using new digital technologies to across Australia, ensuring the platform is develop health systems that better meet the tested to meet the diverse needs, contexts holistic needs of young people with mental and experiences of Australia’s young people. health issues. Working with InnoWell Pty Ltd (a joint venture between the University of Sydney and PricewaterhouseCoopers), we are trialling the use of a digital platform that can be tailored to the unique needs of the young person, which is then collaboratively The University of Sydney managed by the person seeking care and their clinician. Page 16 Personalised and responsive care General mental health The current diagnostic approach in mental Our broad program of research also includes: healthcare services can be ambiguous, −− developing novel suicide- particularly in the early stages of an illness. prevention strategies This is a major challenge for clinicians when −− the effects of cannabidiol on brain trying to identify the most suitable and metabolism and inflammation using effective treatment strategies. To this end, we position emission tomography (PET) have developed a new clinical staging model to help clinicians accurately identify the −− youth cyberbullying Youth Mental Health severity of the illness a young person they are −− personalised approaches to education assisting may have. and employment participation −− mechanistic studies to understand the With this knowledge, options for safer neurobiological basis of mental illnesses and more effective interventions can be in young people, including assessment discussed between the young person and of neuropsychology, neuroimaging and their treating team, in line with the stage of sleep-wake and circadian rhythms illness the young person has. This approach −− digitally-supported care pathways will help healthcare providers deliver better for the delivery of better care quality services, especially to young people for young people with emerging who have a clear need for mental health mood or psychotic disorders care but may not otherwise receive it. It can also help clinicians consider the potential −− standardised screening, assessments trajectory or future pathway of an illness to and novel immune therapies in atypical better guide individual support, intervention mood and psychotic disorders. and service design.

Clinical, cognitive, and circadian profiling of young inpatients with severe mental disorders

As a part of the clinical service at Key projects and clinical trials St. Vincent’s Private Hospital – USpace, we are recruiting young patients aged between 16 and 30 (mean age of about 18), with varying and comorbid disorders (largely a primary diagnosis of depression), including psychotic symptoms. Clinical, cognitive, and circadian profiling of this patient cohort will increase our knowledge about different phenotypes within young people with severe mental disorders. This knowledge will be used to develop measured-based, highly personalised treatment strategies. headspace Day being celebrated at Camperdown Page 17 Youth Mental Health Highlights

Collaborating to Dagmar Koethe sydney.edu.au/brain-mind Project Synergy begins investigate the role of sleep appointed as Associate implementation phase patterns in mood disorders Professor in Psychiatry We have begun supporting the Together with Monash University, Associate Professor Dagmar Koethe implementation and evaluation the National Institute of Mental will lead clinical trials researching of the InnoWell Platform across Health and international emotionally unstable patients 11 different headspace locations collaborators, the Brain and Mind and support corresponding trials around Australia, including: Centre is leading key research in a variety of psychiatric and −− five centres within the North into abnormalities in the body neuropsychiatric conditions, Coast Primary Health Network clock as an underlying cause of such as affective disorders, early footprint; specifically, Port mood disorders. While abnormal psychosis and autoimmune-related Macquarie, Grafton, Lismore, sleep–wake patterns are commonly mental health disorders. Tweed Heads and Coffs Harbour reported in mood disorders, it is currently unclear how disruption −− five centres within the Central of the circadian body clock and Eastern Sydney Primary contributes to the development Health network footprint; and persistence of these mental specifically, Camperdown, illnesses, and how correcting this Bondi Junction, Ashfield, can improve outcomes. With the Hurstville and Miranda latest international expertise, this

Brain and Mind Centre Annual Report 2017-18 −− headspace Edinburgh North. research is at the forefront of the field and is conducted with the aim headspace Camperdown was of providing important information the first of the sites to go live in to guide the improvement of November 2018, with the InnoWell treatment for young people with Platform offered as part of care mood disorders. delivery within this service. Headspace Port Macquarie, Lismore and Edinburgh North have also gone live, with over 400 young people invited to use the platform across these centres to-date. It is anticipated that the platform will be live in the remaining centres by September 2019. The University of Sydney

Page 18 headspace Day welcome address

New database to track years of research Fellowships awarded Grants and major projects Over the last 10 years, youth mental Professor Ian Hickie has been Crisis resolution team health research at the Brain and awarded a National Health Optimisation and Relapse Mind Centre has provided a wide and Medical Research Council prevention (CORE) translational variety of data across different (NHMRC) Senior Principal Research research for the Australian and measures and in differing formats. Fellowship: Optimising personalised digital environments Youth Mental Health 2018 saw the development of a Care, at scale, for Young People Led by: Milton, A. powerful integrated database with Emerging Mood Disorders Supported by: Hickie, I. specifically to access and analyse & Davenport. T. this data efficiently, expanding the Granting body: Brain and potential for research that utilises Mind Centre Research this youth mental health data. Development Grant Years: 2019–2020 Amount: $20,000

Project Synergy: continuing the co-design, development, implementation and evaluation of the InnoWell Platform Led by: Hickie, I., Davenport, T. & Cross, S. Granting body: Australian Government Department of Health Years: 2017–2020 Amount: $30M

headspace Day collateral Highlights Page 19 Youth Mental Health Key publications

1. Merikangas, K.R., Swendsen, 4. Ospina-Pinillos, L., Davenport, 7. Crouse, J.J., Moustafa, A.A.,

sydney.edu.au/brain-mind J., Hickie, I.B., Cui L., Shou, T., Iorfino, F., Tickell, A., Cross, Bogaty, S.E.R., Hickie, I.B., & H., Merikangas, A.K., Zhang, S., Scott, E.M., & Hickie, I.B. Hermens, D.F. (2018) Parcellating J., Lamers, F., Crainiceanu, (2018). Using new and innovative cognitive heterogeneity in early C., Volkow, N.D., & Zipunnikov, technologies to assess clinical psychosis-spectrum illnesses: V. (2018). Real-time mobile stage in early intervention A cluster analysis. Schizophrenia monitoring of the dynamic youth mental health services: Research, 202:91-98. associations among motor Evaluation study. Journal of activity, energy, mood, and sleep Medical Internet Research, 8. Cross, S.P., Scott, J.L., in adults with bipolar disorder. 20(9):e259. Hermens, D.F., & Hickie, I.B. JAMA Psychiatry. Advance (2018). Variability in clinical online publication. doi 10.1001/ 5. Carpenter, J.S., Robillard, R., outcomes for youths treated jamapsychiatry.2018.3546. Hermens, D.F., Naismith, S.L., for subthreshold severe Gordon, C., Scott, E.M., & Hickie, mental disorders at an early 2. Chervonsky E., & Hunt, C. (2018). I.B. (2017). Sleep-wake profiles intervention service. Psychiatric Emotion regulation, mental and circadian rhythms of core Services, 69(5):555-561. health, and social wellbeing in temperature and melatonin a young adolescent sample: A in young people with affective 9. Tickell AM, Lee RSC, Hickie concurrent and longitudinal disorders. Journal of Psychiatric IB, et al. The course of investigation. Emotion, 9(2), Research, 94:131-38. neuropsychological functioning 270-282. in young people with attenuated

Brain and Mind Centre Annual Report 2017-18 6. Iorfino, F., Hermens, D.F., Cross, vs discrete mental disorders. 3. Lee, R.S.C., Hermens, D.F., S.P.M., Zmicerevska, N., Nichles, Early Interv Psychiatry 2017. Naismith, S.L., Kaur, M., A., Groot, J., Guastella, A.J., Guastella, A.J., Glozier, N., Scott, Scott, E.M., & Hickie, I.B. (2018). 10. Scott, J., Murray, G., Henry, C., J., Scott, E.M., & Hickie, I.B. Prior suicide attempts predict Morken, G., Scott, E., Angst, (2018). Clinical, neurocognitive worse clinical and functional J., Merikangas, K.R., & Hickie, and demographic factors outcomes in young people I.B. (2017). Activation in bipolar associated with functional attending a mental health disorders: A systematic review. impairment in the Australian service. Journal of Affective JAMA Psychiatry, 74(2):189-196. Brain and Mind Youth Cohort Disorders, 238:563-69. Study (2008–2016). BMJ Open, 8(12):e02265. The University of Sydney Page 20 Researcher Spotlight Dr Frank Iorfino

Dr Frank Iorfino’s PhD, completed in 2018, “I enjoy working in a truly clinical research focused on modelling social and occupational team, where researchers, clinicians, young functioning, as well as studying suicidality people and their families are working outcomes, for young people attending youth together to solve real-world problems mental health services. Titled ‘Personalised through research and development in mental health care for young people: Using a health service environment,” Frank past outcomes to build future solutions’, says. “I feel privileged to work within a this work contributed to our understanding multidisciplinary team that is so motivated of how to identify young people at risk for and focused on having a real impact. It’s poor illness trajectories. It also explored the special to be in a position where you can see development of health-service solutions to the ways your work is changing the lives of some of these problems, by investigating the people your research aims to improve.” the use of new technologies to help services identify and monitor young people’s outcomes over time. Youth Mental Health This work played a significant role in the development of a new technology platform that is being implemented and tested in mental health services across Australia through Project Synergy, a series of research trials conducted by the University of Sydney and InnoWell. As a post-doctoral research fellow for Project Synergy, Frank is continuing his work in this area with a focus on evaluating and improving the real-world applicability and integration of the platform.

“I feel privileged to work within a multidisciplinary team that is so motivated and focused on having a real impact”

Dr Frank Iorfino, Youth Mental Health

Dr Frank Iorfino Page 21 Patient spotlight Jess’s story

Mood disorders can affect every part of a person’s life. For some, it makes working, studying and socialising impossible. This was certainly the case for Jess, who lived with depression for much of her life. “I was severely depressed and had constant battles with anxiety from a young age” Jess recalls. Simple daily tasks like eating, sleeping and sydney.edu.au/brain-mind showering became unbearable. Eventually, Jess was forced to leave high school. She couldn’t be in public without experiencing severe anxiety and struggled with self-harm and suicidal thoughts.

It was a chance meeting between Jess’s mother and a psychiatrist working with headspace and the Brain and Mind Centre Jess got her driver’s licence on her first attempt that sparked change for Jess. She took part in one of its research programs involving cognitive studies, MRI scans and sleep research.

“The Brain and Mind Centre is pretty much the reason I am here today” Jess says. Jess is now in her final year of university. She works part-time and maintains strong, loving relationships with her family and partner. She’s also become a mental health advocate Brain and Mind Centre Annual Report 2017-18 and met the Prime Minister.

Today, Jess is able to see herself in a different “The Brain and Mind Centre light. “I started to break away from the is pretty much the reason I constant years I had been referring to and believing myself to be a mental illness and am here today” nothing more”, she says. Jess By getting treatment and support she Brain and Mind Centre patient needed, Jess defied her own expectations and can now live a life that is defined by her achievements, not her illness. The University of Sydney Page 22 Psychology Clinic _

Accredited postgraduate training in clinical psychology and affordable therapy for the general public. Psychology Clinic Page 23 Psychology Clinic Our core business

The Psychology Clinic sits within the Clinical Psychology Unit (CPU) located at the Brain and Mind Centre. This unit is part of the School of Psychology within the Faculty of Science. The CPU provides sydney.edu.au/brain-mind the theoretical foundation of clinical psychology practice and the Psychology Clinic is devoted to the translation of this knowledge to clinical practice in a real-life, dynamic, clinical setting.

The Clinic enables the development of The CPU accepts a total of 20 post-graduate trainees with the competencies necessary Master of Clinical Psychology and Master of to be a clinical psychologist, through Clinical Psychology and Doctor of Philosophy direct clinical experience, supported by trainees each year. Trainees commence careful supervision of this practice. The their clinical academic training in Semester Clinic provides a comprehensive clinical 1 and begin their Psychology Clinic Internal psychological assessment and treatment Placement in Semester 2 for a period of service to people within our University and 12-months. broader community. There is a dual purpose then: to provide a service to our trainees In 2018, 2400 occasions of service were and to the community of people seeking provided across 3 clinic days. In addition, psychological assistance. some 171 appointments were related to the School of Psychology and the various Brain and Mind Centre Annual Report 2017-18 The Clinic provides affordable psychological research projects of the Masters of Clinical assessment, early intervention and Psychology/PhD trainees (MCP/PhD). These treatment services across the lifespan research projects relate to investigations of for a broad range of psychological and Adult Autism Spectrum Disorder and Social mental health difficulties, including anxiety, Anxiety Disorder in adults and children. depression, life events, grief and loss, health and illness, relationships, parenting and Our broad aim is to continue to maintain our family, behavioural difficulties, study and high level training through the provision of work, resilience, and learning difficulties high quality evidence-based psychological for adults and children. Self-referrals as interventions, as well as supporting the well as secondary and tertiary referrals School of Psychology and Clinical Psychology are received from within the University Unit’s MCP/PhD clinical research program. community including the Counselling and Longer term goals include systematising a Psychological Service (CAPS), headspace, database that allows for an investigation of Camperdown and the General Practice the prevalence of mental health difficulties service in the Wentworth Building. Referrals presenting to our Clinic, across the lifespan, are also received from the wider community, and examining treatment outcomes following

The University of Sydney including General Practitioners, Psychiatrists, treatment with our service. and Adult and Child Mental Health Services within the Sydney Metropolitan Area. Page 24 Psychology Clinic Highlights

−− Provision of over 2000 occasions of −− Continuing to conduct clinical service for the early intervention and research leading to publications treatment of psychological and mental −− Establishing new networks for clinical health difficulties utilising evidence- training in diverse populations, most based practice for the University recently with the Health Services and wider community in 2018 Division Central Australian Aboriginal −− Over 20 post-graduate clinical Congress Aboriginal Corporation psychology trainees successfully completing their training onto full registration as psychologists with over 80% achieving work in their

field within a year of graduation Psychology Clinic Highlights Page 25 Psychology Clinic Key publications

1. Butow, P., Turner, J., Gilchrist, 6. Jones, E., Sharpe, L. (2017). 12. Scott, A., Sharpe, L., Hunt, C., J., Sharpe, L., Smith, A., Fardell, Cognitive bias modification: Gandy, M. (2017). Anxiety and J., Tesson, S., O’Connell, A review of meta-analyses. depressive disorders in people R., Girgis, A., Gebski, V., Journal of Affective Disorders, with epilepsy: A meta-analysis. sydney.edu.au/brain-mind Asher, R., Bell, M., Beith, J., 223, 175-183. Epilepsia, 58(6), 973-982. Grunewald Zola, K., Thewes, B., et al (2017). Randomized 7. Joplin, S., Stewart, E., Gascoigne, 13. Scott, A., Sharpe, L., Thayer, Z., Trial of ConquerFear: A M., Lah, S. (2018). Memory Miller, L., Wong, T., Parratt, K., Novel, Theoretically Based Rehabilitation in Patients with Nikpour (Mohamed), A. (2018). Psychosocial Intervention for Epilepsy: a Systematic Review. A qualitative examination and Fear of Cancer Recurrence. Neuropsychology Review, 28(1), theoretical model of anxiety in Journal of Clinical Oncology, 88-110. adults with epilepsy. Epilepsy 35(36), 4066-4077. and Behavior, 85, 95-104. 8. Mantz, S., Abbott, M. (2017). 2. Dudeney, J., Sharpe, L., Jaffe, A., Obsessive-Compulsive Disorder 14. Sesel, A., Sharpe, L., Naismith, S. Jones, E., Hunt, C. (2017). Anxiety in Paediatric and Adult Samples: (2018). Efficacy of Psychosocial in youth with asthma: A meta- Nature, Treatment and Cognitive Interventions for People with analysis. Pediatric Pulmonology, Processes. A Review of the Multiple Sclerosis: A Meta- 52(9), 1121-1129. Theoretical and Empirical Analysis of Specific Treatment Literature. Behaviour Change, Effects. Psychotherapy and 3. Hadzic, R., Sharpe, L., Wood, B. 34(1), 1-34. Psychosomatics, 87(2), 105-111. (2017). The Relationship Between Pacing and Avoidance in Chronic 9. Mantz, S., Abbott, M. (2017). 15. Sharpe, L., Brookes, M., Jones, Pain: A Systematic Review and The relationship between E., Gittins, C., Wufong, E., Brain and Mind Centre Annual Report 2017-18 Meta-Analysis. The Journal of responsibility beliefs and Nicholas, M. (2017). Threat Pain, 18(10), 1165-1173. symptoms and processes in and fear of pain induces obsessive compulsive disorder: attentional bias to pain words: 4. Hay, P., Touyz, S., Arcelus, J., A systematic review. Journal An eye-tracking study. European Pike, K., Attia, E., Crosby, R., of Obsessive-Compulsive and Journal of Pain, 21(2), 385-396. Madden, S., Wales, J., La Puma, Related Disorders, 14, 13-26. M., Heriseanu, A., et al (2018). A 16. Smith, A., Sharpe, L., Thewes, randomized controlled trial of 10. McAulay, C., Mond, J., Touyz, B., Turner, J., Gilchrist, J., the compuLsive Exercise Activity S. (2018). Early intervention for Fardell, J., Girgis, A., Tesson, TheraPy (LEAP): A new approach bipolar disorder in adolescents: S., Descallar, J., Bell, M., to compulsive exercise in A psychosocial perspective. Butow, P., et al (2018). Medical, anorexia nervosa. International Early Intervention in Psychiatry, demographic and psychological Journal of Eating Disorders, 12(3), 286-291. correlates of fear of cancer 51(8), 999-1004. recurrence (FCR) morbidity 11. Menzies, R., Zuccala, M., in breast, colorectal and 5. Heriseanu, A., Hay, P., Corbit, Sharpe, L., Dar-Nimrod, I. (2018). melanoma cancer survivors with L., Touyz, S. (2017). Grazing in The effects of psychosocial probable clinically significant

The University of Sydney adults with obesity and eating interventions on death anxiety: FCR seeking psychological disorders: A systematic review of A meta-analysis and systematic treatment through the associated clinical features and review of randomised controlled ConquerFear study. Supportive meta-analysis of prevalence. trials. Journal of Anxiety Care in Cancer, 26(12), Clinical Psychology Review, 58, Disorders, 59, 64-73. 4207-4216. 16-32. Page 26 Child Behaviour Research Clinic _

Enhancing children’s wellbeing, preventing problems later in life. Child Behaviour Research Clinic Page 27 Child Behaviour Research Clinic Our core business

Child Behaviour Research Clinic Our team brings together behaviour problems. Our research internationally regarded clinicians aims to identify the mechanisms and researchers in child mental that contribute to vulnerability, sydney.edu.au/brain-mind health and development. We work resilience and development in with children 2-8 years of age children and their families. who present a range of emotional and social development concern, We also offer training internships including disruptive behaviour for clinical psychologists wishing disorders, autism, emotional to learn the latest state-of-the- problems and impulsivity/ art assessments and treatment hyperactivity. as part of their masters or doctoral training. The Child Behaviour Research Clinic is a research-based clinic, offering advanced, evidence-based treatment programs that provide families with the latest strategies in child behaviour management. Families are considered research partners, such that we work alongside parents, forming a team to maximise learning about what works best for children with Brain and Mind Centre Annual Report 2017-18 The University of Sydney Page 28 Child Behaviour Research Clinic Grants / funding Child Behaviour Research Clinic

$1,265,015 An Evidence-based $192,000 The role of oxytocin $849,540 Early childhood mental Intervention for Mental Health in attachment patterns and health: Pathways, treatment, and Disorders in Rural Children. socio-emotional development, community literacy. Dadds. NHMRC Dadds, Hawes, Brennan. NHMRC Eapen, Silove, Dadds, Barnett, and Research Fellowship APP1136058, Partnership Grant APP1056878 with Kohlhoff. ARC Linkage Grant 2016- 2018-2022. Royal Far West 2013-2017. 2019 LP160100249 $128,000 A novel treatment for $2,634,400 Like Father Like Son: $1,287,730 Mapping the specific childhood autism. Dadds, Tully, A National Approach to Violence, pathways to early-onset mental Eapen, Hawes, Rotary Health Antisocial Behaviour and the Mental health disorders. Dadds, Eapen, Research Fund. 2019-2020 Health of Men and Boys. Dadds et Frick, Kimonis, Hawes, Moul, Mehta. al., Movember Foundation Award NHMRC Project Grant 2017-2021 2015-2017. APP1127952.

$843,495 Transgenerational $846,110 An integrated cycles of violence model in Timor- model of environmental, Leste. Silove, Rees, Steel, Tol, Eapen neurodevelopmental, and

& Dadds. NHMRC Project Grant epigenetic resistance and Grants / funding 2015 – 2019 APP1086732 responsiveness to early intervention in childhood psychopathology. Dadds, Hawes, Mehta, Kimonis, Frick. NHMRC Project Grant 2017- 2021 APP1123072. Page 29 Child Behaviour Research Clinic Key publications

1. Dadds, MR., English, T., 3. Dadds, M. R., Moul, C., Hawes, D. 5. Dadds, M.R., Moul, C., Cauchi, A., Wimalaweera, S., Schollar-Root, J., Mendoza Diaz, A., & Brennan, Dobson-Stone, C., Hawes, D.J., sydney.edu.au/brain-mind O., & Hawes, DJ (2019). Can J. (2016). Individual Differences Brennan, J., & Ebstein, R. (2014). reciprocated parent-child eye in Childhood Behavior Methylation of the oxytocin gaze and emotional engagement Disorders Associated With receptor gene and oxytocin enhance treatment for children Epigenetic Modulation of the blood levels in the development with conduct problems and Cortisol Receptor Gene. Child of psychopathy. Development callous-unemotional traits; A Development, 86, 1311-1320. This and Psychopathology, 26, 33-40. proof-of-concept trial. Journal paper integrates, replicates Related to paper (2) above, this of Child Psychology and and extends 3 previous studies was the first study to show that Psychiatry. This is a landmark providing tentative evidence children with a virulent form of paper showing for the first time that epigenetic changes to conduct disorder are in part that reciprocated parent-child the DRD4 gene are associated driven by problematic regulation eye gaze can be used within an with symptom profiles in of the oxytocin receptor early intervention program to young children. It provides gene. The findings have now remediate pathways to severe clear evidence of a specific been replication in a 13 year conduct problems in children. mechanism in dopamine longitudinal study in the UK. regulation that can be used 2. Moul, C., Hawes, D.J., & to index ADHD profiles and be 6. Fay-Stammbach, T., Hawes, Dadds, M.R. (2018). Mapping targeted for future drug and D. J., Meredith, P. (2017). Child the developmental pathways other treatment development. maltreatment and emotion of child conduct problems socialization: Associations Brain and Mind Centre Annual Report 2017-18 through the neurobiology of 4. Dadds MR, Allen JL, McGregor with executive function in the empathy. Neuroscience and K, Woolgar M, Viding E, & Scott, preschool years. Child Abuse Biobehavoral Reviews, 91, S. (2014). CU traits in children & Neglect, 64, 1-12. The first 34-50. This is a major review and mechanisms of impaired study to report that parenting of neurodevelopmental eye contact during expressions practices based on emotion systems involved in empathy of love: A treatment target? socialization may protect and its disturbance in Journal of Child Psychology against the neurocognitive child psychopathology. and Psychiatry, 55, 771-780. (executive function) deficits This paper represents the exhibited by children exposed culmination of several lead up to substantiated maltreatment studies identifying a specific in the preschool years. treatment target for early intervention with children showing the most virulent and biologically-driven form of early-onset conduct disorder. The University of Sydney Page 30 7. Imm Sng, K., Hawes, D. J., 9. Fairchild, G., Hawes, D. J., Frick, Raine, A., Ang, R.P., Yoon Phaik P. J., Copeland, W. E., Odgers, O., Fung, D.S.S. (2018). Callous C. L., Franke, B., Freitag, C. unemotional traits and the M., & De Brito, S. A. (in press). relationship between aggressive Conduct disorder. Nature parenting practices and conduct Reviews Disease Primers. This problems in Singaporean major review of the current families. Child Abuse & Neglect, state of evidence for conduct 81; 225-234. The first study to disorder spans epidemiology,

show that CU traits differentially disease mechanisms, diagnosis, Child Behaviour Research Clinic moderate associations between screening, prevention, and parenting and proactive/ treatment, and like all Nature reactive aggression in Reviews Disease Primers children with clinic-referred is authored by scientists externalising problems. recognised as international leaders in the field of the 8. Johnson, A. M., Hawes, D. J., respective disease: Eisenberg, N., Kohlhoff, J., Dudeney, J. (2017). Emotion socialization and child conduct problems: A comprehensive review and meta-analysis. Clinical Psychology Review, 54, 65-80. The first study to provide meta-analytic evidence that unsupportive emotion socialization parenting practices are significantly associated with severity of conduct problems. Key publications Page 31

Gambling Treatment and Research Clinic sydney.edu.au/brain-mind _

Working to reduce the impact of problem gambling in the community. Brain and Mind Centre Annual Report 2017-18 The University of Sydney Page 32

Gambling Treatment and Research Clinic Our core business

We strive to better understand the psychology of gambling and to minimise gambling-related harms in the community, through high‑quality research and evidence-based therapies, and the training and education of clinicians in the gambling treatment sector. We collaborate with consumers, industry partners, government and NGOs to apply our research in the real world. Gambling Treatment and Research Clinic Gambling Treatment and Research Clinic The Gambling Treatment and Research Clinic (GTRC), situated within the School of Psychology and the Brain and Mind Centre, is Australia’s only university-affiliated gambling treatment provider. Led by Co-Directors Professor Alex Blaszczynski and Dr Sally Gainsbury, the GTRC has attracted funding of $4 million over four years for a clinical service and $1.2 million over the past three years for research. Our psychologists and clinical psychologists offer cognitive- behavioural based counselling services to individuals experiencing gambling-related difficulties. Our core business

Professor Alex Blaszczynski and Dr Sally Gainsbury Page 33 Gambling Treatment and Research Clinic Research

Research is central to the communities, and treatment operation of the clinic. We focus professionals. Strong international sydney.edu.au/brain-mind on understanding the psychology collaborative links also support the of gambling behaviours, defining multidisciplinary research. concepts of recovery and harm, and the effectiveness of All members of the research interventions and prevention team routinely present research strategies, in order to provide best- findings at local and international practice treatment. Our research conferences and have recently includes venue-based gambling, been asked to share their work at including electronic gaming government forums including the machines, or “pokies”, which NSW Gambling Help Forum, and have the greatest contribution to gambling industry conferences such harms. We are also investigating the as the Australian Gaming Expo and rapidly rising impact of emerging the Gaming, Racing and Wagering technologies on gambling harms, Australia conference. Several and behavioural addictions more members of the research team broadly, including online gaming. are active committee members of the National Association Gambling harms significantly for Gambling Studies, and PhD impact individuals, families and students are active members of the Australian community, as the Brain and Mind Centre HDR Brain and Mind Centre Annual Report 2017-18 around 1% of adults experience Student Committee. severe gambling problems and a further 1.4-2.1% experience Our research objectives are to moderate harms. Gambling is expand our expert research highly accessible in Australia on gambling to include other through venues and online websites behavioural addictions, with a and apps and there is a high strategic focus on problematic comorbidity between gambling and risk-taking related to emerging other mental health disorders. technologies, including online gaming, social media, mobile and The GTRC and its leaders are wearable devices, virtual reality, recognized internationally for and digital currency. We seek to their research excellence and are be recognized as world leaders in frequently invited to contribute these areas and are focusing on to government, industry and issues pertaining to mental health community policy and practice and well-being and prevention of to minimize gambling-related harms. These are growing fields

The University of Sydney harms. Our research has a strong with strong social and economic focus on stakeholder engagement, impacts, but which currently lack including working closely with the research to inform theoretical state, national, and international conceptualisation, policy governments, industry operators, and practice. Page 34 Gambling Treatment and Research Clinic Clinical practice

Over the past two years, the We complement our core cognitive Gambling Treatment and Research and behavioural treatment program Clinic (GTRC) has made significant with dialectical behaviour therapy progress in clinical treatment (DBT) groups. While standard services, internship training and treatments result in significant research into the psychology reductions in gambling behaviour of gambling. With locations in for many clients, other clients Camperdown, Campbelltown, struggling with emotion regulation Lidcombe and Parramatta, our do not fare so well. DBT groups

team have worked diligently focus on teaching clients emotion Gambling Treatment and Research Clinic to establish the GTRC at the regulation and distress tolerance forefront of innovation, treatment skills. These groups also encompass and training. Funded by the clients with other substance and NSW Government through its impulse control disorders. Responsible Gambling Trust, the GTRC has treated a large number of individuals presenting with issues related to excessive gambling and its negative consequences. Over three years, we have offered approximately 3,126 sessions and in 2018, we saw our 2000th client. This substantial increase was largely as a result of effective use of the internet to promote our services.

Problem gambling has a huge impact on families and personal relationships. We have developed a manual for significant others to guide them in helping a loved one regain control of their behaviours Clinical practice and/or encourage them to seek treatment. We also offer couples counselling to help couples address their concerns and deal with loss of trust within the relationship. Page 35 Gambling Treatment and Research Clinic Cultural outreach and education

Our counselling practices are Clinical Masters students. To date, culturally sensitive. Staff members we have trained 36 interns from sydney.edu.au/brain-mind attend training in cultural various universities. We host regular awareness, understanding and presentations and discussion appreciation of the diversity forums with gambling counsellors of Aboriginal and Torres Strait from across Sydney to ensure that Islander culture. Recognising the relevant research findings are prevalence of gambling-related translated into clinical practice. problems among Aboriginal communities, we have forged strong The GTRC places a strong focus links with Marin Weejali Aboriginal on research training and offers Corporation in the Western Sydney supervision for PhD, Masters, and region. We are proud to also be Honours students. The GTRC building partnerships with the further hosts international students Emerton Men’s Shed and Ngallu currently undertaking postgraduate Wal Aboriginal Child and Family research. A research internship Centre. In the first 12 months of our program has been very successful Aboriginal community outreach with 15 interns supervised in 2017 activities, we treated around 90 and 2018. The internships have been clients. Owing to the great demand, highly successful with outcomes in late 2017, we expanded the including joining the GTRC as DBT program at Marrin Weejali to research assistants or postgraduate Brain and Mind Centre Annual Report 2017-18 include an advanced group. students, peer-review publications, gaining competitive scholarships In addition to the provision of and awards and placement into clinical services, we place a clinical programs. strong emphasis on education and professional development for students and counsellors. A significant initiative by Senior Clinician Dr Fadi Anjoul has been the development of a treatment manual. We offer internship placements and supervision for provisional psychologists including The University of Sydney Page 36 Gambling Treatment and Research Clinic Industry engagement

The GTRC’s research team has worked closely with both industry and government stakeholders to carry out policy-relevant research with real-world impact in gambling venues. The research team has worked with industry partners ClubsNSW to develop a comprehensive, responsible gambling staff training program, Gambling Treatment and Research Clinic which will be empirically evaluated in venues across NSW later this year. The research team has also collaborated with ClubsNSW to collect data for evaluation of their multi-venue self-exclusion program, which allows gamblers to ban themselves from multiple gambling venues under a single registration procedure. Research from this project commenced in 2015 and is ongoing with the collection of longitudinal data. Since commencement, the research has already resulted in 2 large industry reports, 2 peer-reviewed academic publications, 2 industry magazine publications, and the presentation of findings at national and international gambling conferences. Industry engagement Page 37 Gambling Treatment and Research Clinic Highlights

Grants awarded Awards

Responsible Gambling Fund Developing online risk taking −− Dr Sally Gainsbury was – University of Sydney – models in multiple domains awarded a University of Sydney Campbelltown. Camden Led by: Gainsbury, S. and Pinkus, R. Vice-Chancellor’s Award for Led by: Blaszczynski, A. Granting body: School of Outstanding Early Career Granting body: NSW Government Psychology, University of Sydney

sydney.edu.au/brain-mind Research (2018). Dr. Gainsbury Department of Industry Years: 2017 was also nominated as one of the Years: 2017-2018 Amount: $15,000 Top 25 People to Watch in the Amount: $227,610 gambling field by Global Gaming Risky gambling and customer Magazine (2018) and awarded Responsible Gambling Fund – wellbeing: The role of financial the Franklin Women 2017 Carer’s University of Sydney – Darlington institutions Travel Scholarship to support Led by: Blaszczynski, A. Led by: Gainsbury, S. her in travelling to London to Granting body: NSW Government Granting body: Commonwealth deliver a keynote address at the Department of Industry Bank Australia, University of GambleAware conference. Years: 2017-2018 Sydney - Industry and Community −− Out of 60 abstract submissions Amount: $485,709 Engagement Seed Fund & Linkage presented at the Brain and Incubator funding Mind Centre Symposium, PhD Responsible Gambling Fund Years: 2017-2018 Candidate Dylan Pickering – University of Sydney – Amount: $55,725 was awarded the best poster Lidcombe Aboriginal prize for his research titled Led by: Blaszczynski, A. Investigation of the impact “What does it mean to recover Granting body: NSW Government of the Interactive Gambling from a gambling disorder?” Department of Industry Amendment Bill 2016 Years: 2017-2018 Led by: Gainsbury, S., Angus, D. $129,643 and Blaszczynski, A. International visits Brain and Mind Centre Annual Report 2017-18 Amount: Granting body: Australian The GTRC has hosted numerous Responsible Gambling Fund – Communication and international academics including University of Sydney – Media Authority from the University of Geneva, Lidcombe/Cumberland Years: 2018 University of Hamburg, and the Led by: Blaszczynski, A. Amount: $88,946 University of Macau. Several Granting body: NSW Government international students have Department of Industry Increasing engagement with completed internships at the Years: 2017-2018 responsible gambling tools among GTRC as part of their postgraduate Amount: $39,750.90 customers of online wagering sites studies to gain further experience Led by: Gainsbury, S. and in gambling research and be The influence of features of the Blaszczynski, A. involved with the GTRC team. online environment on risk taking Granting body: Responsible Led by: Gainsbury, S. Wagering Australia Granting body: Australian Years: 2018-2019 Research Council Amount: $159,925 Years: 2016-2020 Amount: $373,401 The University of Sydney

Media The GTRC team is frequently featured in mainstream countries), the Today Show, ABC News, Weekend national and international media related to gambling, Sunrise, SBS Insight, ABC Radio National, Triple J Hack, online gaming, and addictions. Notable appearances A Current Affair, Studio 10, ABC Life, and ABC Drive.

Page 38 include on the Jim Jefferies Show (broadcast in 13 Gambling Treatment and Research Clinic Key publications

1. Ladouceur, R., Shaffer, P., 5. Gainsbury, S. & Blaszczynski, Blaszczynski, A., & Shaffer, H.J. A. (2017). How blockchain and (2018). Brief report: Responsible cryptocurrency technology gambling research and industry could revolutionize online funding biases. Journal of gambling. Gaming Law Review, Gambling Behavior. doi:10.1007/ 21(7), 482-492. doi:10.1089/ s10899-018-9792-9 glr2.2017.2174

2. Adolphe, A., Khatib, L., van 6. Pickering, D., Keen, B., Entwistle, Golde, C., Gainsbury, S., & G., & Blaszczynski, A. (2017). Blaszczynski, A. (2018). Crime Measuring treatment outcomes and gambling disorders: A in gambling disorders: A systematic review. Submitted systematic review. Addiction. Journal of Gambling doi: 10.1111/add.13968 Gambling Treatment and Research Clinic Studies, doi.org/10.1007/ s10899-018-9794-7 7. Pickering, D, Blaszczynski, A., & Gainsbury, S. (2017). Multi-venue 3. Gainsbury, S.M., Tobias- self-exclusion for gambling Webb, J., & Slonim, R. (2018). disorders: A retrospective Behavioural economics and process investigation. Journal of gambling: A new paradigm for Gambling Issues. approaching harm-minimisation. Gaming Law Review. doi:10.1089/ 8. Baggio, S. Gainsbury, S.M., glr2.2018.22106 Starcevic, V., Richard, J-B., Beck, F., & Billieux, J. (2018). 4. Blaszczynski, A. (2108). Gender differences in gambling Responsible gambling: The need preferences and problem for collaborative government, gambling: A network-level industry, community and analysis. International Gambling consumer involvement. SUCHT, Studies, 18(3), 512-525. doi:10.108 64, 64, 307-315. https://doi. 0/14459795.2018.1495750 org/10.1024/0939-5911/a000564 Key publications Page 39 ForeFront Ageing and Neurodegeneration sydney.edu.au/brain-mind _

At the forefront of research into ageing and neurodegeneration. Brain and Mind Centre Annual Report 2017-18 The University of Sydney Page 40 ForeFront Ageing and Neurodegeneration Our core business

The ForeFront Ageing and Neurodegeneration team is committed to discovering early detection methods, identifying new treatments and understanding the underlying mechanisms of neurodegenerative disease.

Neurodegenerative diseases are Our long-term research aims becoming increasingly prevalent in are to be able to improve and

our ageing population. They have expedite diagnosis and to better ForeFront Ageing and Neurodegeneration a devastating impact on those understand how neurodegenerative affected and their families, and processes work so that we can have a huge economic and social treat and potentially halt these impact on our society. Our research debilitating diseases. groups work together to help reduce this impact by improving the Our collaborative research services offered to those affected, program incorporates several enhancing support for carers and research groups and laboratories, offering new hope through clinical all focused on different but trials and the development of interrelated aspects of ageing and novel treatments. neurodegeneration.

Our research covers most neurodegenerative disorders, including frontotemporal dementia, motor neurone disease, Parkinson’s disease, dementia with Lewy bodies, and Alzheimer’s disease, as well as healthy brain ageing. Our core business

Finding solutions to world health problems Page 41 ForeFront Ageing and Neurodegeneration ForeFront research teams

Clinical research on ageing Clinical research on motor magnetic stimulation (TMS) and dementia neurone disease technique, which has been shown to be sensitive in diagnosing motor Healthy Brain Ageing Program, Motor Neurone Disease neurone disease and has the led by Professor Sharon Naismith Research Group, led by Professor

sydney.edu.au/brain-mind potential to be used to identify We aim to determine whether Matthew Kiernan biomarkers in multiple sclerosis and changes in vascular risk factors, We are a multidisciplinary team other degenerative disorders. mood, sleep and lifestyle can focused on clinical neurology. effectively reduce cognitive decline, We work to understand Clinical research on symptoms of depression and the mechanisms behind dementia-related brain changes neurodegenerative diseases, Parkinson’s disease and in later life. Our research targets develop novel diagnostic tools dementia with Lewy bodies modifiable risk factors by providing and trial new treatment strategies. Clinical Parkinson’s Disease early identification, intervention We are currently investigating and Dementia with Lewy Bodies and prevention programs for people mechanisms, biomarkers and Research Group, led by Professor at risk for dementia. We evaluate possible prevention strategies Simon Lewis clinical interventions, including for neurodegeneration in motor Our research is dedicated to brain-training programs, group- neurone disease, frontotemporal improving the quality of life for based psychoeducation programs dementia, chemotherapy-induced people with Parkinson’s disease, to improve sleep disturbance, neurotoxicity, stroke, Machado- dementia with Lewy bodies and home-based exercise programs for Joseph disease, spinal muscular related disorders and, ultimately, people with early-stage dementia, atrophy and other inherited to finding a cure for these diseases. and the development of internet- neuropathies. We also conduct By working with people with based tools to improve health and clinical trials to investigate potential parkinsonism, we aim to find ways wellbeing, reduce depression and treatments for motor neurone Brain and Mind Centre Annual Report 2017-18 to predict the disease and to stem minimise vascular risk factors in disease, chronic inflammatory its progression. We work closely older adults. demyelinating polyneuropathy and with other researchers who focus other disorders. on brain conditions related to Frontier Frontotemporal Dementia Parkinson’s disease. We participate Research Group, led by Professor Neurodegenerative and in NeuroSleep, the Centre for John Hodges and Professor Neuromuscular Diseases Group Translational Sleep and Circadian Olivier Piguet at the Westmead Institute, led by Neurobiology, which ran until 2018 Frontotemporal dementia is Professor Steve Vucic and sought to better understand the second-most common We research the underlying the relationship between sleep degenerative disease that causes mechanisms behind and a healthy brain. From 2019, dementia in younger adults. Our neurodegenerative disorders we are participating in the research group is dedicated to such as motor neurone disease, Centre of Research Excellence to identifying better ways to diagnose frontotemporal dementia and Optimise Sleep in Brain Ageing and frontotemporal dementia, finding amyotrophic lateral sclerosis (ALS), Neurodegeneration (CogSleep). the cause and developing effective as well as neuromuscular diseases treatments for the condition. Our like multiple sclerosis. multidisciplinary research examines A key issue for many patients is The University of Sydney the neurological, psychological that treatment is delayed due and biological brain function in to the lack of reliable diagnostic frontotemporal dementia, as well tests. In collaboration with as how the disease impacts on the Professor Matthew Kiernan, we lives of patients and their families. are commercialising our novel threshold-tracking transcranial Page 42 Genetic research on Laboratory-based research In November 2018, Sydney hosted the 11th International Conference Neurodegeneration on neurodegeneration on Frontotemporal Dementias, Genetics of Movement Disorders Dementia and Movement which was a huge success. Hosting Group, led by Professor Disorders Laboratory, led by 770 delegates over three days, the Carolyn Sue Professor Glenda Halliday conference brought together global Our research aims to improve Our laboratory studies the leaders in frontotemporal dementia diagnostic methods and genetic origin and development of (FTD) research. The conference testing for patients with Parkinson’s neurodegenerative dementias and was chaired by Professor Olivier disease and other inherited movement disorders. Our focus Piguet and provided a fantastic forms of movement disorders. is on how neurodegeneration opportunity for the ForeFront

By identifying causative genes manifests when symptoms first researchers to showcase their ForeFront Ageing and Neurodegeneration involved in these disorders, we are show and how this relates to work on FTD with the international able to create patient-derived cell genetic makeup, changes identified experts. It also ran a carer’s day, models with biologically relevant in the brain, and blood markers of which was a great opportunity for levels of abnormal proteins to different pathologies. The aim is to carers of research participants further understand pathogenic identify and validate biomarkers to get expert advice from all over mechanisms of disease. Our that could be used in the diagnosis the world. experiments have led to the of neurodegenerative diseases discovery of novel disease pathways and/or to monitor responses to Representing the Brain and Mind and new treatment approaches. new classes of drugs for these Centre, and in collaboration with debilitating disorders. the University of Sydney, the Neurogenetics and Epigenetics ForeFront team has established Research Group, led by Associate Neurodegeneration Research the Sydney Dementia Network, Professor John Kwok Laboratory, led by Associate linking dementia researchers with Our group studies the relationship Professor Kay Double Local Health Districts, particularly between genetic changes and Our research is focused on Sydney Local Health District, features of dementia and related understanding the cause and and researchers in other fields, disorders. We also examine neurodegenerative processes as well as providing a forum for lifestyle and epigenetic factors in Parkinson’s disease and other more direct public engagement in these diseases. Our research movement disorders so that we and partnerships. The network is studies genetic variants in specific can better treat and, ultimately, expected to aid in the identification genes that have been implicated prevent these conditions. Our of important gaps in dementia in sporadic and heritable laboratory-based research focuses research, guiding the University’s ForeFront research teams forms of dementia and other on understanding how degenerative research priorities. neurodegenerative diseases. disorders such as Parkinson’s We focus on understanding disease, dementia with Lewy bodies how genetic mutations cause and motor neurone disease damage or increase the risk of disease brain and nerve cells. We are also in order to work towards better researching how we can achieve treatment strategies. slower disease progression and better quality of life for patients. We work to develop better and earlier diagnostic tools and targeted treatment strategies for Parkinson’s disease. Page 43 ForeFront Ageing and Neurodegeneration Highlights

Fellowships awarded Grants awarded The excellent scholarship produced Motor Neurone Disease Research NHMRC FTD and MND by the ForeFront Ageing and Institute of Australia (MNDRIA) program grant sydney.edu.au/brain-mind Neurodegeneration team continues Postdoctoral Fellowships: Led by: Halliday, G., Mattick, J., to attract support, including the −− Dr Emma Devenney: Behaviour, Hodges, J., Kiernan, M., Piguet, O., following nine fellowships awarded cognition, eye-movements Kril, J., Ittner, L., Kassiou, M., Loy, C. to researchers. and psychiatric disease in Granting body: NHMRC Program C9orf72 MND and FTD; a cross grant National Health and Medical modal-approach to facilitate Years: 2018-2022 Research Council (NHMRC) early and accurate diagnosis Amount: $17,069,580 Fellowships: −− Dr William Huynh: A multimodal Motor Neurone Disease: Patient- −− Professor Sharon Naismith: Novel approach combining novel centred care for a progressive assessment and intervention for electrophysiological and neurological disease – dementia: an inter-disciplinary neuroimaging techniques to evidence driving policy translational approach (NHMRC explore the pathophysiological Led by: Kiernan, M. and Vucic, S. Boosting Dementia Research mechanisms and disease spread Granting body: NHMRC Partnership Leadership Fellowship) in motor neurone disease Project −− Dr Carol Dobson-Stone: Years: 2018-2023 Discovery of novel Sydney Research Accelerator Amount: $771,042 neurodegeneration genes via (SOAR) Fellowships, 2018: next-generation sequencing −− Associate Professor Inflammatory markers in technologies and high- Muireann Irish: Managing GBA carriers with and without

Brain and Mind Centre Annual Report 2017-18 throughput cellular assays memory loss in dementia Parkinson’s disease (NHMRC Boosting Dementia −− Dr James Shine: Cognition Led by: Dzamko, N. Research Leadership Fellowship) and attention in dementia Granting bodies: Shake it Up −− Dr Fiona Kumfor: Social and −− Dr Carol Dobson- Australia Foundation, The Michael Behavioural disturbances in Stone: Uncovering the J Fox Foundation for Parkinson’s dementia: optimising detection genetics of dementia Research and the University and treatment (NHMRC Career of Sydney Development Fellowship) Years: 2018-2019 −− Dr Sicong Tu: Neural signatures Amount: $272,514 of disease spread and evolution in motor neurodegenerative syndromes (NHMRC Early Career Fellowship) The University of Sydney Page 44 Are there peripheral changes in Nix mediated mitophagy: A Pathophysiology, site of disease GBA protein/activity in idiopathic new therapeutic approach to onset and mechanisms of spread Parkinson’s disease patients? Parkinson’s disease in amyotrophic lateral sclerosis Led by: Halliday, G., Dzamko, N., Led by: Sue, C. and Fu, Y. Led by: Vucic, S., Menon, P and and Lewis, S. Granting body: NHMRC Project Huynh, W. Granting bodies: Shake it Up Grant Granting body: NHMRC Project Australia Foundation and The Years: 2018 - 2020 Grant Michael J Fox Foundation for Amount: $674,428 Years: 2017 - 2021 Parkinson’s Research Amount: $704,270 Years: 2018-2019 BRAIN-MEND: Biological ForeFront Ageing and Neurodegeneration Amount: $232,300 Resource Analysis to Identify New Healthy gums and muscles for a Mechanisms and Phenotypes in healthy brain program Testing posterior parietal Neurodegenerative Diseases Led by: Erberhard J, Naismith SL, cortex contributions to human Led by: Kwok, J. Duffy SL, Ruiz K episodic memory Granting body: NHMRC Boosting Granting body: Royal Freemasons Led by: Irish, M. and Hodges, J. Dementia Research Grants Benevolent Institution Granting body: ARC Discovery Years: 2018-2021 Years: 2018-2020 Project Amount: $529,967 Amount: $180,000 Years: 2018 -- 2020 Amount: $358,912 The economic impact of providing precision medicine through The role of mutant CYLD in whole-genome sequencing frontotemporal dementia and Led by: Sue, C. and Davis, R. motor neurone disease Granting body: NHMRC Partnership Led by: Dobson-Stone, C. and Project Kwok, J. Years: 2018 - 2022 Granting body: NHMRC Project Amount: $1,144,787 Grant Years: 2018 --2021 Amount: $963,216 Highlights Page 45 ForeFront Ageing and Neurodegeneration Key publications

Dementia Motor neurone disease 1. McKeith, I.G., Boeve, B.F., 1. Mathey, E.K., Garg, N., Park, S.B., Dickson, D.W., Halliday, G., Nguyen, T., Baker, S., Yuki, N., sydney.edu.au/brain-mind Taylor, J.P., Weintraub, D., Yiannikas, C., Lin, C.S., Spies, Aarsland, D., Galvin J., Attems, J.M., Ghaoui, R., Barnett, M.H., J., Ballard, C.G., Bayston, A., Vucic, S., Pollard, J.D., & Kiernan, Beach, T.G., Blanc, F., Bohnen, M.C. (2017). Autoantibody N., Bonanni, L., Bras, J., Brundin, responses to nodal and P., Burn, D., Chen-Plotkin, paranodal antigens in chronic A., Duda, J.E., El-Agnaf, O., inflammatory neuropathies. Feldman, H., Ferman, T.J., Journal of Neuroimmunology, Ffytche, D., Fujishiro, H., 309:41-6. Galasko, D., Goldman, J.G., Gomperts, S.N., Graff-Radford, 2. van Rheenen, W., Shatunov, N.R., Honig, L.S., Iranzo, A., A., Dekker, A.M., McLaughlin,

Pages from Diagnosis and management Kantarci, K., Kaufer, D., Kukull, R.L., Diekstra, F.P., Pulit, S.L., of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium W., Lee, V.M.Y., Leverenz, J.B., van der Spek, R.A., Võsa, U., de Lewis, S., Lippa C., Lunde, A., Jong, S., Robinson, M.R., Yang, Masellis, M., Masliah, E., McLean, J., Fogh, I., van Doormaal, P.T., P., Mollenhauer, B., Montine, Tazelaar, G.H., Koppers, M., T.J., Moreno, E., Mori, E., Murray, Blokhuis, A.M., Sproviero, W., M., O’Brien, J.T., Orimo, S., Jones, A.R., Kenna, K.P., van Eijk, Postuma, R.B., Ramaswamy, K.R., Harschnitz, O., Schellevis,

Brain and Mind Centre Annual Report 2017-18 S., Ross, O.A., Salmon, D.P., R.D., Brands, W.J., Medic, J., Singleton, A., Taylor, A., Thomas, Menelaou, A., Vajda, A., Ticozzi, A., Tiraboschi, P, Toledo, J.B., N., Lin, K., Rogelj, B., Vrabec, K., Trojanowski, J.Q., Tsuang, Ravnik-Glavač, M., Koritnik, B., D., Walker, Z., Yamada, M., & Zidar, J., Leonardis, L., Grošelj, Kosaka, K. (2017). Diagnosis and L.D., Millecamps, S., Salachas, management of dementia with F., Meininger, V., de Carvalho, Lewy bodies: Fourth consensus M., Pinto, S., Mora, J.S., Rojas- report of the DLB Consortium, García, R., Polak, M., Chandran, Neurology, 89(1):88-100. S., Colville, S., Swingler, R., Morrison, K.E., Shaw P.J., Hardy, 2. van Hummel, A., Chan, G., van J., Orrell, R.W., Pittman, A., der Hoven, J., Morsch, M., Ippati, Sidle, K., Fratta, P., Malaspina, S., Suh, L., Bi, M., Asi, P.R., Lee, A., Topp, S., Petri, S., Abdulla, W.S., Butler, T.A., Przybyla, S., Drepper, C., Sendtner, M., M., Halliday, G.M., Piguet, O., Meyer, T., Ophoff, R.A., Staats, Kiernan, M.C., Chung, R.S., Ittner, K.A., Wiedau-Pazos, M., Lomen-

The University of Sydney L.M., & Ke, Y.D. (2018). Selective Hoerth, C., Van Deerlin, V.M., spatiotemporal vulnerability of Trojanowski, J.Q., Elman, L., central nervous system neurons McCluskey, L., Basak, A.N., to pathologic TAR DNA-Binding Tunca, C., Hamzeiy, H., Parman, Protein 43 in aged transgenic Y., Meitinger, T., Lichtner, mice. American Journal of P., Radivojkov-Blagojevic, Pathology, 188(6):1447-1456. M., Andres, C.R., Maurel, C., Bensimon, G., Landwehrmeyer, Page 46 B., Brice, A., Payan, C.A., Saker- Parkinson’s Disease genetic architecture of Delye, S., Dürr, A., Wood, N.W., dementia with Lewy bodies: 1. Postuma, R.B., Poewe, W., Tittmann, L., Lieb, W., Franke, A., a two-stage genome-wide Litvan, I., Lewis, S., Lang, A.E., Rietschel, M., Cichon, S., Nöthen, association study, The Lancet Halliday, G., Goetz, C.G., Chan, M.M., Amouyel, P., Tzourio, C., Neurology, 17(1):64-74. P., Slow, E., Seppi, K., Schaffer, Dartigues, J.F., Uitterlinden, E., Rios-Romenets, S., Mi, A.G., Rivadeneira, F., Estrada, 3. Walton, C., Mowszowski, L., Gilat, T., Maetzler, C., Li, Y., Heim, K., Hofman, A., Curtis, C., Blauw, M., Hall, J., O’Callaghan, C., B., Bledsoe, I.O., & Berg, D. H.M., van der Kooi, A.J., de Visser, Muller, A., Georgiades, M., Szeto, (2018). Validation of the MDS M., Goris, A., Weber, M., Shaw, J., Ehgoetz Martens, K., Shine, J., clinical diagnostic criteria for C.E., Smith, B.N., Pansarasa, O., Naismith, S., & Lewis, S. (2018). Parkinson’s disease, Movement Cereda, C., Del Bo, R., Comi, G.P., Cognitive training for freezing Disorders, 33(10):1601-1608. D’Alfonso, S., Bertolin, C., Sorarù, of gait in Parkinson’s disease: a G., Mazzini, L., Pensato, V., Gellera, randomized controlled trial. NPJ 2. Guerreiro, R., Ross, O.A., Kun- C., Tiloca, C., Ratti, A., Calvo, A., Parkinson’s Disease, 4(15). Rodrigues, C., Hernandez, D.G., Moglia, C., Brunetti, M., Arcuti, S., Orme, T., Eicher, J.D., Shepherd, Capozzo, R., Zecca, C., Lunetta, 4. Trist, B.G., Davies, K.M., Cottam, C.E., Parkkinen, L., Darwent, L., C., Penco, S., Riva, N., Padovani, V., Genoud, S., Ortega, R., Heckman, M.G., Scholz, S.W., A., Filosto, M., Muller, B., Stuit, R.J., Roudeau, S., Carmona, A., De Troncoso, J.C., Pletnikova, O., ForeFront Ageing and Neurodegeneration PARALS Registry, SLALOM Group, Silva, K., Wasigner, V., Lewis, Ansorge, O., Clarimon, J., Lleo, SLAP Registry, FALS Sequencing S.J.G., Sachdev, P., Smith, B., A., Morenas-Rodriguez, E., Consortium, SLAGEN Consortium, Troakes, C., Vance, C., Shaw, C., Clark, L., Honig, L.S., Marder, NNIPPS Study Group, Blair, I., Al-Sarraj, S., Ball, H., Halliday, K., Lemstra, A., Rogaeva, E., Zhang, K., McCann, E.P., Fifita, G., Hare, D.J., Double, K.L. (2017) St George-Hyslop, P., Londos, J.A., Nicholson, G.A., Rowe, D.B., Amyotrophic lateral sclerosis- E., Zetterberg, H., Barber, I., Pamphlett, R., Kiernan, M.C., like superoxide dismutase 1 Braae, A., Brown, K., Morgan, K., Grosskreutz, J., Witte, O.W., Ringer, proteinopathy is associated Troakes, C., Al-Sarraj, S., Lashley, T., Prell, T., Stubendorff, B., Kurth, with neuronal loss in Parkinson’s T., Holton, J., Compta, Y., Van I., Hübner, C.A., Leigh, P.N., Casale, disease brain. Acta Neuropathol. Deerlin, V., Serrano, G.E., Beach, F., Chio, A., Beghi, E., Pupillo, E., 134(1):113-127. T.G., Lesage, S., Galasko, D., Tortelli, R., Logroscino, G., Powell, Masliah, E., Santana, I., Pastor, J., Ludolph, A.C., Weishaupt, J.H., P., Diez-Fairen, M., Aguilar, M., Ageing Robberecht, W., Van Damme, P., Tienari, P.J., Myllykangas, L., Franke, L., Pers, T.H., Brown, R.H., 1. Naismith, S., Pye, J., Terpening, Oinas, M., Revesz, T., Lees, A., Glass, J.D., Landers, J.E., Hardiman, Z., Lewis, S., & Bartlett, D. (2018). Boeve, B.F., Petersen, R.C., O., Andersen, P.M., Corcia, P., “Sleep Well, Think Well” group Ferman, T.J., Escott-Price, V., Vourc’h, P., Silani, V., Wray, N.R., program for mild cognitive Graff-Radford, N., Cairns, N.J., Visscher, P.M., de Bakker, P.I., van impairment: A randomized Morris, J.C., Pickering-Brown, S., Es, M.A., Pasterkamp, R.J., Lewis, controlled pilot study. Mann, D., Halliday, G.M., Hardy C.M., Breen, G., Al-Chalabi, A., Behavioral Sleep Medicine, J., Trojanowski, J.Q., Dickson, van den Berg, L.H., & Veldink, J.H. 24:1-12.

D.W., Singleton, A., Stone, D.J., & Key publications (2016). Genome-wide association Bras, J. (2018). Investigating the analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis, Nature Genetics, 48(9):1043-8.

Professor Sharon Naismith

with a brain scan. Page 47 Researcher Spotlight Dr Carol Dobson-Stone

Dr Carol Dobson-Stone is a molecular Australian family with several people affected geneticist interested in genes that are with dementia”, Carol explains. “This gene mutated in dementia and related diseases. encodes an enzyme involved in autophagy, She completed her PhD in human genetics a process by which the cell breaks down at the University of Oxford, UK, in 2004, and unwanted or misfolded proteins. This is shortly thereafter moved to Sydney to work the first time that this enzyme has been on brain function genetics, at the Garvan implicated in brain disease, and no-one has Institute. Carol then worked at Neuroscience yet examined its pathogenic role”. sydney.edu.au/brain-mind Research Australia and in 2017, she joined the Brain and Mind Centre as a Senior Research In January 2018, Carol was awarded a Sydney Fellow, working on the genetics of dementia. Research Accelerator (SOAR) Fellowship to help expand her research into this gene. She “Our cognitive capabilities are what make us is examining how the gene mutation affects uniquely human”, says Carol, “and dementia cell functions to cause nerve cell death, robs people of this humanity. The greatest using cutting-edge cell and mouse models risk factor for dementia is age and so as the of disease. Carol aims to find out whether population ages, more and more people will people who have more common variants of become affected.” It is predicted that by the this gene are at greater risk of developing year 2050, around 950,000 Australians will dementia. “I hope that my research into have dementia, for which there is currently this and other genes will provide crucial no effective treatment. Carol’s research knowledge for diagnosing and developing aims to uncover the genes involved in the new treatments for this debilitating group of pathogenesis of different forms of dementia, disorders”, she says. as the first step on the pathway towards designing treatments for these disorders. “We recently identified a mutation in a gene that is responsible for disease in a large Brain and Mind Centre Annual Report 2017-18

“The greatest risk factor for dementia is age and so as the population ages, more and more people will become affected”

Dr Carol Dobson-Stone The University of Sydney

Dr Carol Dobson-Stone Page 48 Sydney Neuroimmunology _

Developing new ways to detect and treat neurological disease. Sydney Neuroimmunology Page 49 Sydney Neuroimmunology Our core business

Our neuroimmunology research focuses on improving our understanding of neurological and psychiatric diseases. It has become clear that many of them are associated with a sydney.edu.au/brain-mind dysregulation of the immune system.

Sydney Neuroimmunology’s team of Children’s Hospital Network, this initiative internationally-renowned clinicians is the first joint initiative of its magnitude and researchers are at the forefront in Australia. Our interdisciplinary team of research into diseases affecting the combines discovery research and clinical brain and mind that are associated with research programs with specialist clinical an immune dysfunction. These so-called care, maximising our capacity to rapidly ‘neuroimmunological’ disorders include progress new discoveries into standard subsets of diseases, such as: clinical practice. −− Autoimmune encephalitides Bringing together our collective expertise, −− Autism we offer specialist diagnostic immunology −− Youth mental health services that expedite the assessment of −− Multiple sclerosis neurological disorders and improve specialist access for physicians.

Brain and Mind Centre Annual Report 2017-18 −− Motor neurone disease −− Movement disorders We are also working to fast-track research −− Myasthenia gravis into neurological disorders by establishing −− Immune-mediated neuropathy a shared data repository for collating and −− Dementia comparing data. This repository is providing unprecedented opportunities to develop Our work includes developing novel novel diagnostic biomarkers of disease and diagnostic biomarkers, exploring the develop new treatments. biological mechanisms that lead to the development of diseases, and implementing By integrating clinical neuroimmunology new and innovative treatments for some of diagnostic services with cutting-edge the most debilitating disorders. research, we are facilitating public access to and participation in clinical trials. We are also Partnering the Brain and Mind Centre working towards better patient outcomes with the Local Health Districts of Sydney, by improving treatment options and the Western Sydney, Northern Sydney and surveillance of therapy. Nepean Blue Mountains, as well as the Sydney The University of Sydney Page 50 Sydney Neuroimmunology Research areas

Our discovery work involves identifying novel immune Sydney Neuroimmunology biomarkers, exploring the role of the immune response in pathogenesis, and linking data in order to support and enable population research.

Clinically, we are working to define clinical phenotypes and treatment outcomes, and conduct both longitudinal clinical studies across the lifespan and trials aimed at improving diagnosis and treatment.

Professor Russell Dale, Paediatric Neurologist, Neuroimmunology team Research areas Page 51 Sydney Neuroimmunology Highlights

Defining the basis of autoimmune attacks against myelin to better target treatment of demyelinating disorders Led by: Brilot-Turville F, Dale R

sydney.edu.au/brain-mind Granting body: National Health and Medical Research Council Project Grants Years: 2018-2021 Amount: $913,216

The effectiveness of tecfidera in amyotrophic lateral sclerosis: A phase II multicentre randomised placebo- controlled study (TEALS) Led by: Kiernan, M. and Vucic, S. Granting body: FightMND Professor Steve Vucic, Neurologist, Years: 2018-2019 Neuroimmunology team Amount: $4.7 million

Understanding the induction of disease Grants awarded quiescence by immunomodulating drug in multiple sclerosis SREI II: Neuroimmunology and Led by: Grau G, Hawke S, Byrne S, Zinger A, neuroinflammation: from biomarker and Barnett M, Hodgkinson S pathogenesis to patient diagnosis and Granting body: MS Research Australia

Brain and Mind Centre Annual Report 2017-18 improvement of clinical outcome Years: 2018 -- 2020 Led by: Brilot-Turville F, Dale R, Brown D, Amount: $225,000 Kiernan M, Marais B, Barnett M, Britton P, Guastella A, Halliday G, Harris A, Hickie I, Novel approaches to mitigating Lewis S, Nassar N, Ramanathan S, Vucic S, heat‑related fatigue in individuals Wood N with multiple sclerosis Granting body: DVC Research/Sydney Led by: Jay O, Barnett M, Davis S, Filingeri D, Research Excellence Initiative 2020 (SREI). Carlsen T, Boyd D Years: 2018-2019 Granting body: MS Research Australia Amount: $300,000 Years: 2018 -- 2020 Amount: $176,000 Nodal function in peripheral neuroinflammatory disorders: Target Does somatic mutation in the brain drive antigens, functional significance and progressive MS? treatment response Led by: Rubio J, Leslie S, Barnett M Led by: Kiernan, M. Granting body: MS Research Australia Granting body: National Health and Years: 2018-2020 Medical Research Council Project Grants Amount: $229,000 The University of Sydney Years: 2016-2019 Amount: $623,975 Fellowships awarded SOAR Fellowship: Michael Barnett ECF fellowship: Sudarshini Ramanathan, 4 years, NHRMC Page 52 Sydney Neuroimmunology Publications

1. Ramanathan, S., Mohammad, S., Tantsis, 7. Christogianni, A., Bibb, R., Davis, S.L., E., Nguyen, T.K., Merheb, V., Fung, V.S.C., Jay, O., Barnett, M., Evangelou, N., & White, O.B., Broadley, S., Lechner-Scott, Filingeri, D., (2018) Temperature sensitivity J., Vucic, S., Henderson, A.P.D., Barnett, in multiple sclerosis: an overview of its M.H., Reddel S,W., Brilot, F., Dale, R.C. & impact on sensory and cognitive symptoms Australasian and New Zealand MOG Study Temperature, 5(3):208-223. Group (2018). Clinical course, therapeutic responses and outcomes in relapsing 8. Reddel, S.W., Barnett, M.H., Riminton, MOG antibody-associated demyelination, D.S., Dugal, T., Buzzard, K.A., Wang, C., Journal of Neurology, Neurosurgery, Fitzgerald, F., Beadnall, H.N., Erickson, D., and Psychiatry, 89(2):127-137. doi: 10.1136/ Gahan, D., Wang, D., Ackland, T., Thompson, jnnp-2017-316880 R. (2018). Successful implementation of an automated electronic support system Sydney Neuroimmunology 2. Kieseier, B.C., Mathey, E.K., Sommer, for patient safety monitoring – the C. & Hartung, H.P. (2018). Immune- Alemtuzumab in Multiple Sclerosis Safety mediated neuropathies, Nature Reviews Systems (AMS3) study. Mult Scler. doi: Disease Primers, 4(1):31. doi: 10.1038/ 10.1177/1352458518783673. [epub ahead s41572-018-0027-2 of print]

3. You, Y., Graham, E.C., Shen, T., Yiannikas, 9. Triplett, J. D., Yiannikas, C., Barnett, M. C., Parratt, J.D.E., Gupta, V., Barton, H., Parratt, J., Barton, J., Graham, S. L., … J., Dwyer, M.G., Barnett, M.H., Fraser, Klistorner, A. (2018). Pathophysiological C.L., Graham, S.L., and Klistorner, A. basis of low contrast visual acuity loss in (2018). Progressive inner nuclear layer multiple sclerosis. Annals of clinical and dysfunction in non-optic neuritis eyes in translational neurology, 5(12), 1505–1512. multiple sclerosis. Neurol Neuroimmunol Neuroinflamm,5:e427 10. Tantsis, E.M., Prelog, K., Alper, G., Benson, L., Gorman, M., Lim, M., Mohammad, 4. Chaseling, G.K., Filingeri, D., Barnett, S.S., Ramanathan, S., Brilot, F., Dale, R.C. M., Hoang, P., Davis, S.L., Jay, O. (2018). (2018). Magnetic resonance imaging in Cold-Water Ingestion Improves Exercise enterovirus-71, myelin oligodendrocyte Tolerance of Heat-Sensitive People glycoprotein antibody, aquaporin-4 with MS. Medicine and science in sports antibody, and multiple sclerosis-associated and exercise. Med Sci Sports Exerc. myelitis in children. Paediatric Myelitis Mri

50(4):643-648. Study Group. Dev Med Child Neurol. doi: Publications 10.1111/dmcn.14114. [epub ahead of print] 5. Fragoso, Y.D., Spelman, T., Boz, C., Alroughani, R., Lugaresi, A., Vucic, S., et 11. Brilot, F. (2018). Relapsing ADEM followed by al. (2018). Lymphocyte count in peripheral optic neuritis in children; a clinical entity blood is not associated with the level associated with anti-MOG antibody. Eur J of clinical response to treatment with Neurol. 25(8):1003-1004 (invited editorial) fingolimod. Multiple sclerosis and related disorders. 19:105-8. 12. Berridge G, Menassa DA, Moloney T, Waters PJ, Welding I, Thomsen S, Zuberi S, Fischer 6. Garber, J. & Barnett, M.H. (2018) R, Aricescu AR, Pike M, Dale RC, Kessler B, Controversies in MS: “We should focus Vincent A, Lim M, Irani SR, Lang B. (2018). more on finding therapeutic targets for the Glutamate receptor δ2 serum antibodies non-inflammatory damage in MS”. Invited in pediatric opsoclonus myoclonus ataxia commentary. Mult Scler. 24(10):1272-1274. syndrome. Neurology 91(8):e714e723 Page 53 13. Dale RC, Nosadini M. (2018). Infection- 20. Filingeri, D., Chaseling, G., Hoang, P., triggered autoimmunity: The case of Barnett, M., Davis, S.L., Jay, O. (2017). herpes simplex virus type 1 and anti- Afferent thermosensory function in NMDAR antibodies. Neurol Neuroimmunol relapsing-remitting Multiple Sclerosis

sydney.edu.au/brain-mind Neuroinflamm. 5(4):e471. following exercise-induced increases in body temperature . Experimental 14. Kothur K, Bandodkar S, Chu S, Wienholt L, physiology 102 (8), 887-893. Johnson A, Barclay P, Brogan PA, Rice GI, Crow YJ, Dale RC. (2018). An open-label 21. Garg, N., Park, S., Nguyen, T., Baker, S., Yuki, trial of JAK 1/2 blockade in progressive N., Yiannikas, C., Lin, C., Spies, J., Ghaoui, IFIH1-associated neuroinflammation. R., Barnett, M., Vucic, S., Pollard, J., Neurology. 90(6):289-291. Kiernan, M. (2017). Autoantibody responses to nodal and paranodal antigens in chronic 15. Tsai VW, Brown DA, Breit SN. Targeting the inflammatory neuropathies. J Neuroimm. divergent TGFβ superfamily cytokine MIC- 309: 41-46. 1/GDF15 for therapy of anorexia/cachexia syndromes.(2018) Curr Opin Support Palliat 22. Kalincik et al. (2017) Towards personalised Care. 12(4):404-409. therapy for multiple sclerosis: prediction of individual treatment response. Brain. 16. Atashrazm, F., Hammond, D., Perera, 140(9):2426-2443 G., Dobson-Stone, C., Mueller, N., Pickford, R., Kim, W.S., Kwok, J.B., Lewis, 23. Swee et al. (2017). Vestibulo-ocular reflex S.J.G., Halliday, G.M., Dzamko, N. (2018). deficits with medial longitudinal fasciculus Reduced glucocerebrosidase activity in lesions. Journal of Neurology. 264: 2119.

Brain and Mind Centre Annual Report 2017-18 monocytes from patients with Parkinson’s disease. Sci Rep.8(1):15446. doi: 10.1038/ 24. Khani, S.E., Vafaee, F., Suter, C., Hawke, S., s41598-018-33921-x. Beadnall, H., Devenney, E. (2017) Exosomal microRNA signatures in multiple sclerosis 17. Barton J, Hardy T, Riminton S, Reddel reflect disease status. Scientific Reports SW, Barnett Y, Coles A and Barnett (Nature). 7: 14293. MH. (2017). Tumefactive demyelination following treatment for relapsing multiple 25. Weissert, R., Brilot, F. (2017). Induction sclerosis with alemtuzumab. Neurology. of Central Nervous System Disease 88(10):1004-1006. by the Adaptive Immune Response. Front Immunol. 8:1218. doi: 10.3389/ 18. Dale, R.C., Barnett, M.H. & Kiernan, M.C. fimmu.2017.01218. (2017). Maternal autoimmunity: risk of neurodevelopmental and neuropsychiatric 26. Chen, K.A., Brilot, F., Dale, R.C., Lafferty, outcomes, Journal of Neurology, A.R., Andrews, P.I. (2017). Hashimoto’s Neurosurgery, and Psychiatry, 88(9):713-714. encephalopathy and anti-MOG antibody doi: 10.1136/jnnp-2017-315724 encephalitis: 50 years after Lord Brain’s description. Eur J Paediatr The University of Sydney 19. Kalincik, T., William, J., Brown, L., Neurol. 21(6):898-901. doi: 10.1016/j. Robertson, N. et al. (2017). Treatment ejpn.2017.06.002. effectiveness of alemtuzumab compared with natalizumab, fingolimod, and 27. Pilli, D., Zou, A., Tea, F., Dale, R., Brilot, F. interferon beta in relapsing-remitting (2017) Expanding Role of T Cells in Human multiple sclerosis: a cohort study. Lancet Autoimmune Diseases of the Central Neurol. 16(4):271-281. Nervous System. Front Immunol. 8:652. doi: Page 54 10.3389/fimmu.2017.00652. 28. Patel, S., Masi, A., Dale, R. C., Whitehouse, 35. Ong, L. T., Galambos, G., & Brown, D. A. J. O., Pokorski, I., Alvares, G. A., ... & A. (2017). Primary Sjogren’s Syndrome Guastella, A. J. (2018). Social impairments associated with treatment-resistant in autism spectrum disorder are related to Obsessive–Compulsive Disorder. Frontiers maternal immune history profile. Molecular in psychiatry, 8, 124. doi: 10.3389/ psychiatry, 23(8), 1794. doi: 10.1038/ fpsyt.2017.00124. mp.2017.201. 36. Mathey, E. K., Garg, N., Park, S. B., Nguyen, 29. Ho, A. C., Mohammad, S. S., Pillai, S. C., T., Baker, S., Yuki, N., ... & Barnett, M. Tantsis, E., Jones, H., Ho, R., ... & Dale, R. H. (2017). Autoantibody responses to C. (2017). High sensitivity and specificity nodal and paranodal antigens in chronic in proposed clinical diagnostic criteria inflammatory neuropathies. Journal of for anti-N-methyl-d-aspartate receptor neuroimmunology, 309, 41-46. doi:10.1016/j. Sydney Neuroimmunology encephalitis. Developmental Medicine & jneuroim.2017.05.002. Child Neurology, 59(12), 1256-1260. doi: 10.1111/dmcn.13579. 37. Britton, P. N., Blyth, C. C., Macartney, K., Dale, R. C., Li-Kim-Moy, J., Khandaker, G., ... 30. Korff, C. M., & Dale, R. C. (2017). & Booy, R. (2017). The spectrum and burden The immune system in pediatric seizures of influenza-associated neurological and epilepsies. Pediatrics, 140(3), doi: disease in children: combined encephalitis 10.1542/peds.2016-3534. and influenza sentinel site surveillance from Australia, 2013–2015. Clinical 31. Dale, R. C., Barnett, M. H., & Kiernan, M. Infectious Diseases, 65(4), 653-660. C. (2017). Maternal autoimmunity: risk of neurodevelopmental and neuropsychiatric outcomes. J Neurol Neurosurg Psychiatry 88(9):713-714. doi: 10.1136/jnnp-2017-315724.

32. Dale, R. C., & Ramanathan, S. (2017). Cell surface antibody–associated neurodegeneration: The case of anti-IgLON5 antibodies. Neurology 88(18), 1688-1690. doi: 10.1212/ WNL.0000000000003931. Publications 33. Dale, R. C., Gorman, M. P., & Lim, M. (2017). Autoimmune encephalitis in children: clinical phenomenology, therapeutics, and emerging challenges. Current opinion in neurology, 30(3), 334-344. doi: 10.1097/ WCO.0000000000000443.

34. Breit, S. N., Tsai, V. W. W., & Brown, D. A. (2017). Targeting obesity and cachexia: identification of the GFRAL receptor–MIC- 1/GDF15 pathway. Trends in molecular medicine, 23(12), 1065-1067. doi: 10.1016/j. molmed.2017.10.005. Page 55 Patient spotlight Lauren’s story

It’s a shock to learn you have a chronic condition. When Lauren was diagnosed with multiple sclerosis at 25, gaining control of her health and pursuing a career were her priorities.

Later, when Lauren lost movement in one of her arms, she realised something was wrong. sydney.edu.au/brain-mind She was taken straight to the emergency department and hospitalised for a week.

It was while in the hospital that a doctor sat with Lauren and asked her about herself, her career and what she did outside work. “He was the one who thought Michael Barnett at the Brain and Mind Centre would be the perfect neurologist for me,” Lauren says. “That’s how I got the referral.”

It has been seven years since Lauren first saw Professor Michael Barnett, a neurologist and multiple sclerosis specialist at the University of Sydney’s Brain and Mind Centre. He has helped Lauren throughout her journey, from navigating the initial diagnosis to treatment and ongoing management. His clinic is the only multiple sclerosis facility in Australia that is based within a university and therefore Brain and Mind Centre Annual Report 2017-18 integrated with the latest research.

“The thing with multiple sclerosis is that if you stop it when you’re young, you don’t have that damage going forward,” says Lauren. “So, it’s really important to get in early and Lauren stop it in its tracks and that’s exactly what Michael did for me.” Lauren had just landed a prestigious job with a top-tier law firm in Sydney. Soon after Lauren has not had any relapses or arriving, this journey came to a standstill after degeneration so far, and she has gone on she paid a visit to her GP. to lead a successful career as an academic lawyer at one of Australia’s top law schools. “He said I was showing signs of multiple sclerosis,” Lauren says. “To be honest, I thought he was crazy. I was doing triathlons, working more than full time and I’d just moved to Sydney for a great The University of Sydney career opportunity.” Page 56 Sleep and Circadian Biology _

Understanding the links between sleep and brain health. Sleep and Circadian Biology Page 57 Sleep and Circadian Biology Our core business

Inadequate or poor-quality sleep and sleep disorders such as insomnia, circadian rhythm disorders and obstructive sleep apnoea are major health problems. Our team are focused on sydney.edu.au/brain-mind leading world-class efforts in delineating the role of sleep and circadian (sleep-wake) disorders for brain and mental health.

In 2016–17, 40% of Australians reported In 2018, the Sleep and Circadian Biology insufficient sleep and 20% complained of team was launched at the Brain and Mind excessive daytime sleepiness. According to Centre, bringing together researchers from a 2017 report by Deloitte Access Economics the Woolcock Institute and the University for the Sleep Health Foundation, the cost of of Sydney faculties of Science, Medicine inadequate sleep in Australia was $26 billion and Health, Engineering, Information in 2016–17 through loss of productivity and Technologies, and Nursing, as well as healthcare costs. Sleep–wake disturbance University multidisciplinary initiatives, also significantly impacts our mental health including the Charles Perkins Centre. Our and wellbeing and contributes to accelerated highly integrated, multidisciplinary team has brain ageing and neurodegeneration. already demonstrated success and attracted funding in recognition of our work, including NHMRC Fellowships and a highly competitive NHMRC grant for the Centre of Research Brain and Mind Centre Annual Report 2017-18 Excellence to Optimise Sleep in Brain Ageing and Neurodegeneration (CogSleep CRE). The University of Sydney Page 58 Sleep and Circadian Biology Current research

Priority areas for our research dementia and Parkinson’s wellbeing, productivity and include child development, youth disease, and the persistence of functioning. Our team works across mental health and dementia, which sleep disturbances predicts the various diseases and collaborates Sleep and Circadian Biology contribute significantly to the global recurrence of depressive illness as closely with existing Brain and burden of disease. At an individual well as cognitive decline. Mind Centre teams to pursue this level, mental health problems and cross-cutting research, including neurodegenerative diseases both It is therefore likely that better the Youth Mental Health, Forefront have deleterious impacts on the efforts to understand and treat Ageing and Neurodegeneration brain, as well as hindering wellbeing sleep-wake disturbance in these and Child Neurodevelopment and and contributing to disability. diseases will have an impact on Mental Health teams. Sleep-wake disturbance is a early intervention and prevention prodromal feature of depression, approaches, as well as optimising The Sleep and Circadian Biology team is co-led by Professor Sharon Naismith, Professor Ron Grunstein and Professor Simon Lewis, who are establishing the team as world leaders in research linking sleep and circadian systems and disorders of the brain and mind, by fostering national and international collaborations. Current research Page 59 Sleep and Circadian Biology Highlights

Grants awarded Awards

CogSleep Centre of Research −− Professor Sharon Naismith Excellence: Sleep-wake received the 2018 Society sydney.edu.au/brain-mind disturbance in ageing and for Mental Health Research neurodegenerative disease Oration Award for Led by: Naismith, S., Grunstein, R., outstanding commitment Lewis, S., Phillips, C., D’Rozario, A., to and achievements in Hoyos, C., Rajaratnam, S., Halliday, psychiatric research. G., Martins, R., Lagopoulos, J. −− Dr Angela D’Rozario was awarded Granting body: National Health and the Helen Bearpark Scholarship, Medical Research Council (NHMRC) one of the most prestigious Years: 2018 - 2023 awards from the Australasian Amount: $2.5m Sleep Association, the national peak professional body for “Local Sleep” in the awake sleep research and medicine. brain: An underlying cause of neurobehavioural deficits in −− Dr Loren Mowszowski was sleep apnea? awarded one of six inaugural Led by: Grunstein, R., D’Rozario, Brain and Mind Centre A., Phillips, C. , Wong, K. ,Hoyos, C., Research and Development Naismith, S., Vakulin, A. &Eckert, D. Grants for early- or mid- Granting body: National Health and career researchers. Medical Research Council (NHMRC) −− Dr Camilla Hoyos was recognised Brain and Mind Centre Annual Report 2017-18 Project Grants with three prestigious national Years: 2018 - 2020 and international awards: Amount: $582,330 the Sleep, Respiratory and Neurobiology Assembly James Cannabinoids and sleep: A Skatrug New Investigator Award randomised, placebo-controlled at the American Thoracic Society crossover pilot study of 20:1 meeting, the BUPA Health CBD:THC for insomnia. Foundation Emerging Health Led by: Grunstein. R., & Hoyos, C.M. Researcher Commendation Granting body: Lambert Initiative Award, and the Young Research Grant, University Researcher Award from Sydney of Sydney Health at the Sydney Innovation Years: 2018 - 2021 and Research Symposium. Amount: $255,712

The Australian Dementia Network (ADNeT): Bringing together

The University of Sydney Australia’s dementia stakeholders Led by: Rowe, C., Sachdev, P. , Naismith, S.L. , Breakspear, M. , Brodaty, H. , Anstey, K. , Martins,R., Ward, S., Vickers, J., & Masters, C.. Granting body: NHMRC Years: 2018 - 2023 Amount: $18,000,000 Page 60 Sleep and Circadian Biology 2019 and beyond

The Sleep and Circadian Our focus for 2019 also includes Biology team will investigate increasing the visibility of our new biomarkers of sleep-wake international leadership in the disturbance that predict cognitive field of sleep and chronobiology. decline, neurodegenerative disease We will be co-leading new global and poor mental health. We will initiatives in sleep and dementia, undertake novel clinical trials for which will feature at the Alzheimer’s sleep-wake disturbance in order Association International to improve cognition and mental Conference in Los Angeles and health and optimise healthy the World Sleep conference Sleep and Circadian Biology brain ageing. We will employ new in Vancouver. technology and data science approaches to surveil symptoms in real-time, and test new e-health interventions. 2019 and beyond

Dr Shantel Duffy with a patient Page 61 Sleep and Circadian Biology Key publications

1. Naismith, S.L. & Mowszowski, 3. D’Rozario, A.L., Bartlett, D.J., L. (2018). Sleep disturbance in Wong, K.K.H., Sach, T., Yang, mild cognitive impairment: a Q., Grunstein, R.R. & Rae, C.D. systematic review of recent (2018). Brain bioenergetics

sydney.edu.au/brain-mind findings. Current Opinion in during resting wakefulness are Psychiatry, 31(2):153-159. related to neurobehavioral deficits in severe obstructive 2. Cross, N.E., Memarian, N., Duffy, sleep apnea: a 31P magnetic S.L., Paquola, C., LaMonica, resonance spectroscopy study. H., D’Rozario, A., Lewis, S.J.G., Sleep, 41(8). Hickie, I.B., Grunstein, R.R. & Naismith, S.L. (2018). Structural 4. D’Rozario, A.L., Field, C.J., brain correlates of obstructive Hoyos, C.M., Naismith, sleep apnoea in older adults S.L., Dungan, G.C., Wong, at risk for dementia. European K.K.H., Grunstein, R.R. & Respiratory Journal, 52(1): Bartlett, D.J. (2018). Impaired 1800740. neurobehavioural performance in untreated obstructive sleep apnea patients using a novel standardised test battery. Frontiers in Surgery, 18(5): 35. doi:10.3389/fsurg.2018.00035. Brain and Mind Centre Annual Report 2017-18 The University of Sydney

L-R Inventor of the CPAP machine, Colin Sullivan, Professor Sharon Naismith and Professor Ron Grunstein Page 62 “Working at the Brain and Mind Centre offers the opportunity to collaborate with leading researchers with different clinical and scientific expertise across a range of research fields”

Dr Shantel Duffy Sleep and Circadian Biology

Dr Shantel Duffy

Researcher Spotlight Dr Shantel Duffy

A postdoctoral research fellow with the Dr Duffy is also currently leading a series discipline of Exercise and Sport Science in of studies exploring the effect of exercise the Faculty of Health Sciences, Dr Shantel interventions on mood and cognition in Duffy works with the Sleep and Circadian individuals living with cognitive impairment, Biology team at the Brain and Mind Centre. as well as residents in aged-care facilities. With a background as an accredited (and practising) exercise physiologist “Working at the Brain and Mind Centre and nutritionist, and bringing advanced offers the opportunity to collaborate with neuroimaging expertise to the team, Dr leading researchers with different clinical Duffy currently holds a prestigious NHMRC– and scientific expertise across a range of ARC Dementia Research Development research fields. In this way, we are uniquely Fellowship. Her research aims to explore placed to explore complex, multidisciplinary the mechanisms underpinning cognitive research questions that have real-world decline and depression in older adults at risk implications”, says Dr Duffy. “The most for dementia. rewarding aspect of my work is interacting every day with individuals who are living She also examines the effect of interventions with cognitive impairment and having the on markers of inflammation and oxidative opportunity to translate our research stress. Dr Duffy has pioneered work exploring findings in to my own clinical practice.” a Magnetic Resonance Imaging (MRI)-derived marker of oxidative stress in individuals at “A key strength of our work is our capacity risk for dementia and/or mood disorders. for translation: we work closely with Internationally, she was the first researcher Dementia Australia and regularly provide to show changes in this marker in people with seminars for both the community and sleep-disordered breathing. clinicians to disseminate our research findings. In this way, I believe we are making a truly meaningful impact in the area of

dementia-prevention research.” Page 63

Computational Neuroscience sydney.edu.au/brain-mind _

Using artificial intelligence to gain insight into the cause and progression of neurological diseases. Brain and Mind Centre Annual Report 2017-18 The University of Sydney Page 64

Computational Neuroscience Our core business

Comprising experts in neuroimaging science, deep learning and clinical neurology, the Brain and Mind Centre’s recently established Computational Neuroscience Team is building a library of algorithms that, when applied to large imaging datasets, will provide insights into the cause and progression of neurological diseases. New imaging biomarkers derived from this work will be used in neuroimaging research, clinical trials and clinical practice. Computational Neuroscience

Funded by a 2018 Australian government The team has also been substantially Cooperative Research Centre project bolstered by an influx of enthusiastic grant, the Team has developed an exciting early-career researchers, including partnership with I-MED Radiology and the imaging scientist Dr Chenyu Wang, recently Sydney Neuroimaging Analysis Centre to appointed as Senior Lecturer and the accelerate the translation of their work in inaugural Nerve Research Foundation Fellow, imaging science and machine learning to and a team of three artificial intelligence clinical medicine and industry, with a focus scientists, including Dr Hao Xiong, a on inflammatory, degenerative and vascular postdoctoral scientist supported by the Brain diseases of the brain. and Mind Centre. Our core business Page 65 Computational Neuroscience Highlights

The team’s expansion in 2018 supported In 2018, the University also signed a three PhD candidates in neuroimaging memorandum of understanding with MSBASE science and the creation of two scholarships Foundation to develop an imaging repository for students in imaging artificial intelligence. and analysis platform for the largest MS

sydney.edu.au/brain-mind The team made significant strides in registry in the world (with upwards of biomarker research, particularly for 70,000 patients). patients with multiple sclerosis (MS). Specifically, this work used new analysis The Computational Neuroscience team’s techniques and algorithms to demonstrate unique mix of clinicians, imaging scientists previously undocumented changes within and deep-learning experts, together with established brain MS lesions over time. access to large-scale datasets such as the These changes have been adapted into MSBASE repository, has the potential to biomarkers that can be used in clinical drive the development of next-generation trials of emerging neuroprotective and biomarkers for precision medicine across the pro-reparative medicines. spectrum of neurological diseases.

Fellowship success Grants awarded Professor Fernando Calamante was awarded Members of the team received the following an NHMRC Research Fellowship: research grants: −− Novel methods to study structural- Brain and Mind Centre Annual Report 2017-18 functional connectivity in AI: new smarts for the Epilepsy and Schizophrenia medical imaging industry Led by: Sydney Neuroimaging Analysis Our team also received two three-year Centre, in partnership with the fellowships from MS Research Australia: Computational Neuroscience team and I-MED Radiology Network −− Dr Chenyu Wang: Developing Granting body: Cooperative Research multimodal quantitative imaging Centre Project (CRC-P) Program biomarkers in multiple sclerosis Years: 2018-2021 −− Dr Justin Garber: Postgraduate Amount: $2.36 million Scholarship – connectomics and other imaging aspects of This study aims to improve diagnostic progressive multiple sclerosis neuroimaging of brain ailments such as multiple sclerosis and dementia. The CRC-P program supports industry-led, outcomes- focused partnerships between industry, researchers and the community: this project

The University of Sydney funding results from a successful and long- standing partnership between the Brain and Mind Centre, Sydney Neuroimaging Analysis Centre and I-MED Radiology Network. Page 66 Computational Neuroscience

Professor Michael Barnett at the Computational Neuroscience Team announcement

NVIDIA Medical Imaging Computational and Cladribine: a multicentre Long- Artificial Intelligence Platform term efficacy Biomarker Australian Led by: Calamante, F., Tao, D. and Barnett, M. Study (CLOBAS) Granting body: University of Sydney/NHMRC Led by: Hunter New England Local equipment grant, with in-kind support Health District, in partnership with the from NVIDIA Computational Neuroscience team and Years: 2018 Sydney Neuroimaging Analysis Centre Amount: $180,000 Collaborators: Sydney Neuroimaging Analysis Centre & Computational Neuroscience team This equipment grant provided funds for Granting body: Merck Serono Australia infrastructure and support for a NVIDIA DGX Years: 2018 - 2027 supercomputer, boosting the Computational Amount: $3.25 million Neuroscience team’s capability in developing artificial intelligence technologies and Implemented in ten sites across Australia,

their application into neurological and this study investigates longitudinal clinical, Highlights neuroinflammatory disease states. genetic, epigenetic and imaging data in a large cohort of multiple sclerosis (MS) patients. The study is expected to uncover further insights into the causes and underlying biology of MS. The Brain and Mind Centre will be one of the clinical trial sites for the study and the Computational Neuroscience team and Sydney Neuroimaging Analysis Centre will additionally lead the imaging analysis for all of the centres involved. Page 67 Computational Neuroscience Key Publications

1. Zhang, C., Song, Y., Liu, S., Lill, S., 5. Klistorner, A., Wang, C., 11. Klistorner et al. Progression Wang, C., Tang, Z., You, Y., Gao, Yiannikas, C., Parratt, J., Dwyer, retinal ganglion cell loss in Y., Klistorner, A., Barnett, M. & M., Barton, J., Graham, S.L., multiple sclerosis is associated Cai, W. (2018). MS-GAN: GAN- You, Y., Liu, S., & Barnett, M.H. with new lesions in the optic based semantic segmentation of (2017). : A longitudinal DTI radiations. Eur J Neurol. 2017 multiple sclerosis lesions in brain study. NeuroImage: Clinical, 17: 24(11):1392-1398

sydney.edu.au/brain-mind magnetic resonance imaging, 1028–35. Digital Image Computing: 12. Klistorner et al. Diffusivity in Techniques and Applications 6. Wang, C., Klistorner, A., Ly, the core of chronic multiple (DICTA), Canberra, Australia. doi: L., & Barnett, M.H. (2018). sclerosis lesions. PLoS One. 10.1109/DICTA.2018.8615771 White matter tract-specific 2018 13(4):e0194142. quantitative analysis in multiple 2. Tang, Z., Wang, C., Hoang, P., Liu, sclerosis: Comparison of 13. Min M, Spelman T, Lugaresi S., Cai, W., Soligo, D., Oliver, R. optic radiation reconstruction A, Boz C, Spitaleri D, Pucci E, & Barnett, M. (2018) Automatic techniques, PLoS ONE, 13(1): 1-19. Grand’Maison F, Granella F, segmentation of thigh muscle Izquierdo G, Butzkueven H, in longitudinal 3D T1-weighted 7. Lu, G., Beadnall, H.N., Barton, J., Sanchez-Menoyo JL, Barnett M, magnetic resonance (MR) Hardy, T.A., Wang, C., & Barnett, Girard M, Trojano M, Grammond images. In: A. Melbourne et al. M.H. (2018). The evolution of ‘No P, Duquette P, Sola P, Alroughani (Eds.) PIPPI 2018, DATRA 2018. Evidence of Disease Activity’ R, Hupperts R, Vucic S, Kalincik Lecture Notes in Computer in multiple sclerosis, Multiple T, Van Pesch V, Lechner- Science: Vol 11076. Data Sclerosis and Related Disorders, Scott J. Silent lesions on MRI Driven Treatment Response 20: 231–38. imaging - Shifting goal posts for Assessment and Preterm, treatment decisions in multiple Perinatal, and Paediatric Image 8. Triplett, J.D., Yiannikas, C., sclerosis. Mult Scler. 2018 Analysis. Granada, Spain: Barnett, M.H., Parratt, J., Oct;24(12):1569-1577

Brain and Mind Centre Annual Report 2017-18 Springer. Barton, J., Graham, S.L., You, Y. & Klistorner, A. (2018). 3. Ting Shen, T., You, Y., Pathophysiological basis of Arunachalam, S., Fontes, A., low contrast visual acuity loss Liu, S., Gupta, V., Parratt, J., in multiple sclerosis. Annals Wang, C., Barnett, M., Barton, of Clinical and Translational J., Chitranshi, N., Zhu, L., Fraser, Neurology, 5(12): 1505-1512. C. L., Graham, S.L., Klistorner, A. & Yiannikas, C. (2018). Differing 9. Garber, J.Y. & Barnett, M.H. structural and functional (2018). We should focus more on patterns of optic nerve damage finding therapeutic targets for in multiple sclerosis and the non-inflammatory damage neuromyelitis optica spectrum in MS – Yes. Multiple Sclerosis, disorder, Ophthalmology, 1-9. 24(10): 1272-1274.

4. Klistorner, A., Wang, C., 10. Destefano N, Silva DG, Barnett Yiannikas, C., Parratt, J., Barton, MH. Effect of Fingolimod on J., You, Y., Graham, S.L. & Brain Volume Loss in Patients The University of Sydney Barnett, M.H. (2018). Diffusivity with Multiple Sclerosis. CNS in the core of chronic multiple Drugs. 2017 Apr;31(4):289-305. sclerosis lesions, PLoS ONE, 13(4): 1-20. Page 68 “I am extremely excited to be applying my basic science and engineering skills to clinical questions and problems that will ultimately directly help patients with multiple sclerosis and other neurological disorders”.

Dr Chenyu (Tim) Wang

Dr Chenyu (Tim) Wang

Researcher Spotlight Dr Chenyu (Tim) Wang

Dr Chenyu (Tim) Wang is the inaugural Nerve With a background in electronic engineering, Research Foundation and Multiple Sclerosis neuroimaging and neuroscience, Dr Wang Computational Neuroscience Research Australia Research Fellow at the is currently focusing his research on Brain and Mind Centre. He completed his neurological disease, aiming both to clarify PhD at the Brain and Mind Centre under the underlying disease pathomechanisms and to supervision of Professor Michael Barnett and develop tools for use in monitoring sub- was awarded the 2018 Peter Bancroft Prize clinical disease progression. by the Faculty of Medicine and Health, a prize given to a graduate whose thesis was passed “I am extremely excited to be applying my by all three examiners without requiring any basic science and engineering skills to clinical emendations or amendments. He is currently questions and problems that will ultimately leading the development of imaging and directly help patients with multiple sclerosis imaging–electrophysiological biomarkers and and other neurological disorders”. researching artificial intelligence solutions for clinical radiology with the Computational Aside from co-authored publications in peer- Neuroscience team at the Brain and reviewed journals and scientific conferences, Mind Centre. his work has also been recognized with travel grant awards from world-leading conference “I am fortunate enough to have the committees for the last four years (including opportunity to work with people from many the International Society for Magnetic different backgrounds at Brain and Mind Resonance in Medicine and the European Centre on almost a daily basis, including Committee for Treatment and Research in neurologists, radiologists, pathologists, Multiple Sclerosis). clinical scientists, imaging physicists, computer scientists and engineers. The Dr Wang is also the Director of Operations unique expertise of these individuals often at the Sydney Neuroimaging Analysis Centre, exposes many different perspectives on the which, co-located with the Brain and Mind same problem, which frequently results in Centre, provides imaging central reading innovative thoughts and wild ideas.” services for phase 2 and 3 clinical trials. Page 69

Technical Facilities _ sydney.edu.au/brain-mind

Sydney Imaging, Neuropathology, Microscopy and Neurology lab. Brain and Mind Centre Annual Report 2017-18 The University of Sydney Page 70

Technical Facilities

Sydney Imaging Preclinical Imaging Sydney Imaging is one of the University of The Brain and Mind Centre is home to Sydney’s core research facilities. Bringing the University of Sydney and ANSTO joint together researchers and clinicians through Node of the Australian National Imaging the provision of exceptional biomedical Facility. This shared facility provides imaging infrastructure and technical researchers with access to state-of-the-art expertise, we tackle frontier questions in imaging capabilities. Together with Sydney healthcare and medical research. Imaging, the preclinical imaging platform includes micro-PET, PET-CT, PET/SPECT/ Sydney Imaging has a base at the Brain and CT and 3T MRI/PET scanners, as well as Mind Centre and provides a comprehensive autoradiography, radiometabolite analysis suite of preclinical and clinical imaging and tissue-counting facilities. modalities in collaboration with partners Technical Facilities such as I-MED and Australia’s Nuclear Our imaging researchers are focused on Science and Technology Organisation developing new technologies for non- (ANSTO). invasive imaging and imaging-biomarker development. We collaborate with a large group of colleagues, both at the Brain and Mind Centre and more broadly nationally and internationally, to develop new imaging methods and test new drugs and interventions for various brain disorders, including neurodegenerative diseases, mood disorders and cancers.

Our imaging scientists have an outstanding track record of innovation in both clinical and preclinical imaging, developing novel technologies for the advancement of neuroimaging research and understanding of disease processes. Page 71 Sydney Neuroimaging Clinical Imaging Analysis Centre The I-MED Radiology Network is a leading Also housed at Brain and Mind Centre’s provider of radiological services across Mallett Street campus is the Sydney Australia, operating a network of radiology Neuroimaging Analysis Centre, a cutting-

sydney.edu.au/brain-mind practices across the country, including an edge facility that uniquely integrates imaging research facility at the Brain and in-house neuroimaging research with a Mind Centre. This facility houses a state- dedicated, regulatory-compliant commercial of-the-art 3 Tesla Magnetic Resonance image analysis facility for Phase 2, 3 and 4 Imaging (MRI) scanner, capable of running clinical research trials. Sydney Neuroimaging structural, diffusion, functional and Analysis Centre is also a major partner in spectroscopic imaging for research as well the Brain and Mind Centre’s Computational as for patient care. A subspecialist neuro- Neuroscience team, supporting a range radiologist reports all scans and is based of imaging and artificial intelligence on site, providing the highest standards of projects and providing infrastructure and imaging reporting for patients attending our support for higher degree (Doctoral and multidisciplinary clinics and for subjects Masters) students. participating in clinical trials at the Brain and Mind Centre, as well as further afield.

Through our collaboration with I-MED Radiology, Brain and Mind Centre researchers have developed a sophisticated multinuclear spectroscopy program that provides the ability to image a range of

Brain and Mind Centre Annual Report 2017-18 spectroscopic nuclei. The technique, known as magnetic resonance spectroscopy (MRS), is used to study the metabolic changes associated with diseases that affect the brain. It also provides additional information on top of the structural information that is obtained from standard MRI sequences alone. I-MED Radiology Network has also partnered with the Sydney Neuroimaging Analysis Centre and the Brain and Mind Centre’s Computational Neuroscience Team to deliver improved diagnostics and patient monitoring through artificial intelligence applied to neuroimaging. The University of Sydney Page 72 Technical Facilities Highlights

Welcome Professor held externally funded international Grants awarded total-body PET workshops at UC Fernando Calamante Davis and the University of Sydney Motion-adaptive PET Sydney Imaging welcomes Professor in 2017–18. technology for brain imaging Fernando Calamante to the role of freely moving mice of Academic Director. Professor Patient motion can degrade This project aims to develop new Calamante specialises in novel the excellent spatial resolution technology for imaging the brain Magnetic Resonance Imaging achievable with this system. As of a freely moving mouse while (MRI) techniques that enable the such, we are working together analysing its learned behaviours. investigation of brain structure, to develop methods for motion The new technology will, for the function and network connectivity, tracking and correction. We first time, enable scientists to study as well as how these are affected have implemented a whole-body the fundamental mechanisms of in disease. Since joining us in 2018, optical motion-tracking system the brain that regulate behaviour Professor Calamante has been on an EXPLORER total-body PET and decision making in mammals, working closely with a number of scanner mock-up at UC Davis and with future applications to human Technical Facilities teams at the Brain and Mind Centre, are using this to study the motion brain disorders. including the Computational of volunteers under a range of Led by: Professor Steven Meikle Neuroscience team. imaging conditions. Collaborators: Professor Simon Cherry (UC Davis) & Dr Andre Kyme (University of Sydney Faculty of Imaging brain behaviour We have been successful in attracting $6.3 million in funding Engineering & IT) In 2017–18, our team has further from the National Collaborative Granting body: ARC enhanced and exploited an Research Infrastructure Strategy Years: 2019–21 innovative technique first (NCRIS) towards Australia’s first Amount: $486,000 developed at the Brain and Mind total-body PET facility and we are Centre, which images the brains seeking a clinical partner to host Total-Body PET technology and of conscious, freely-moving small and operate the system. methods for biological systems laboratory animals with positron research in metabolic disorders emission tomography (PET). This and mental illness CT brain imaging without technique allows us to study the This project aims to establish chemical changes that take place in motion artifacts the first total-body PET facility the brain as a result of learning and Patient head motion causes in Australia and to develop other behaviours, and how these artifacts that hamper accurate motion-correction and kinetic- normative changes are affected by diagnosis in patients undergoing modelling methodology for brain abnormalities and disease. computed tomography (CT) scans this new technology which will In recent developments, we have to assess trauma, stroke and enable imaging of physiological extended this unique research other brain conditions. Our team, function in all tissues of the body Highlights tool to deliver images with better in collaboration with Professor simultaneously with extremely spatial resolution, and the ability Johan Nuyts and his team at the KU high sensitivity. to produce voxel-wise maps of Leuven in Belgium, has developed Led by: Professor Steven Meikle 3D neurotransmitter responses to and applied for a patent on a Collaborators: Professor Simon stimuli during imaging experiments. data-driven motion estimation/ Cherry (UC Davis) correction algorithm to eliminate Granting body: University of Total-body PET technology these artifacts. Current clinical Sydney–University of California, evaluation suggests that it may find Davis Priority Partnership We have strengthened our its most valuable application in CT Collaboration Awards Program collaboration with Professor Simon perfusion imaging, where accurate Years: 2017–18 Cherry’s team at the University images of the core infarct and its Amount: $40,000 of California, Davis (UC Davis), penumbra are critical in selecting on applications of the innovative the optimal treatment for patients total-body PET technology, having with acute stroke. Page 73 Technical Facilities Key publications

1. Kyme, A.Z., Angelis, G.I., 5. Lu, Y., Fontaine, K., Mulnix, T., 9. Cochran, B., Ryder, W., Parmar, Eisenhuth, J., Fulton, R.R., Onofrey, J., Ren, S., Panin, V., A., Klaeser, K., Reilhac, A., Zhou, V., Hart, G., Popovic, K., Jones, J., Casey, M., Barnett, Angelis, G., Meikle, S., Barter, Akhtar, M., Ryder, W.J., Clemens, R., Kench, P., Fulton, R., Carson, P. & Rye, K. (2017). Determining sydney.edu.au/brain-mind K., Balleine, B., Parmar, A., R., & Liu, C. (2018). Respiratory glucose metabolism kinetics Pascali, G., Perkins, G., & Meikle, motion compensation for PET/ using 18F-FDG micro-PET/ S.R. (2018). Open-Field PET: CT with motion information CT. Journal of Visualized Simultaneous brain functional derived from matched Experiments, 2(123). doi: imaging and behavioural attenuation corrected gated 10.3791/55184 response measurements PET data. Journal of Nuclear in freely moving animals. Medicine, 59(9):1480-1486. 10. Gillam J., Angelis, G., Kyme, NeuroImage, 188: 92-101. doi:10.2967/jnumed.117.203000 A., & Meikle, S. (2017). Motion compensation using origin 2. Angelis, G., Gillam, J.E., Ryder, 6. Sun, T., Clackdoyle, R., Kim, ensembles in awake small animal W., Fulton, R., & Meikle, S.R. J-H., Fulton, R., & Nuyts, J. positron emission tomography, (2018). Direct estimation of (2018). Estimation of local Physics in Medicine and Biology, voxel-wise neurotransmitter data-insufficiency in motion- 62(3): 715-733. response maps from dynamic corrected helical CT. IEEE PET data, IEEE Transactions Transactions on Radiation on Medical Imaging. Advance and Plasma Medical Sciences, online publication. doi: 10.1109/ 1(4):346-357. TMI.2018.2883756 7. Angelis, G., Ryder, W., Gillam, 3. Kyme, A., Se, S., Meikle, S., & J., Boisson, F., Kyme, A., Fulton, Brain and Mind Centre Annual Report 2017-18 Fulton, R. (2018). Markerless R., Meikle, S., & Kench, P. (2017). motion estimation for motion- Rigid motion correction of dual compensated clinical brain opposed planar projections in imaging. Physics in Medicine single photon imaging. Physics and Biology, 63(10): 105018. in Medicine and Biology, 62(10): doi:10.1088/1361-6560/aabd48 3923-3943.

4. Angelis, G., Gillam, J., Kyme, A., 8. Kyme, A., Judenhofer, M., Gong, Fulton, R. & Meikle, S. (2018). K., Bec, J., Selfridge, A., Du, J., Image-based modelling of Qi, J., Cherry, S., & Meikle, S. residual blurring in motion (2017). Open-field mouse brain corrected small animal PET: Design optimisation and PET imaging using motion detector characterisation. dependent point spread Physics in Medicine and Biology, functions. Biomedical Physics 62(15): 6207-6225. & Engineering Express. doi:10.1088/2057-1976/aab922 The University of Sydney Page 74 Technical Facilities Neuropathology

Our extensive expertise in clinical Our neuropathology research −− disease (CJD) diagnosis and research neuropathology program is part of the Royal −− statewide forensic allows us to analyse the molecular Prince Alfred Hospital Department neuropathology services for and cellular bases of neurological of Neuropathology, the only all three NSW forensic hubs diseases, including brain tumours neuropathology department in New −− non-coronial-autopsy and neurodegenerative conditions. South Wales and one of only two neuropathology for complex in Australia and New Zealand. We neurological disease In doing so, we can identify new provide a broad suite of specialist ways of diagnosing these disorders diagnostic expertise, including: −− muscle biopsy pathology in conjunction with the when the disease first manifests, −− tissue-based diagnostic Neurology laboratory at the allowing patients to benefit from services for the Royal Prince Royal Prince Alfred Hospital. the most effective interventions Alfred Hospital and Chris Technical Facilities available, as early as possible. O’Brien Lifehouse (including By increasing our knowledge of brain biopsies for a wide the underlying bases of these variety of brain disease and diseases, we can help progress brain tumour resections) the development of new and more −− a second-opinion service for effective treatments. complex brain biopsy cases from across NSW and overseas We are working on developing novel blood tests that enable −− a comprehensive NATA- early detection of major diseases, accredited molecular including brain tumours and testing service for brain multiple sclerosis. We are also tumours, including massively investigating brain tumour tissue parallel sequencing to learn more about its complex −− a NSW state referral laboratory genetic makeup and how brain for biopsy and autopsy tumours manipulate their diagnosis of atypical/rapidly surroundings in order to grow. progressive dementias, including Creutzfeldt-Jacob Neuropathology Page 75 Technical Facilities Highlights

−− 2018 saw the NATA-accreditation of Neuropathology’s massively parallel sequencing service for clinical diagnostic use with brain tumours: an Australian sydney.edu.au/brain-mind first. The service receives over 500 brain tumour specimens annually from across Australia and New Zealand for molecular analysis. In gliomas, the most common intrinsic brain tumours, adding molecular information on top of the microscopic diagnosis has led to marked refinement of diagnostic accuracy. −− In March 2018, we launched the Australian Sports Brain Bank (brainbank. org.au) to better understand the links between sporting head injuries and neurodegenerative disease. Over 80 sportspeople have committed to donating their brains for study after their deaths, and three brains have already been retrieved. Our results on our first brain examination were widely reported in the media. Read more at https://www. theage.com.au/sport/afl/study-of- Brain and Mind Centre Annual Report 2017-18 concussed-footballer-s-brain-yields- surprising-results-20190314-p5148l.html −− Our research into a new blood test for brain tumours is accelerating, with the findings of our promising pilot study published in NPJ Precision Oncology (Ebrahimkhani et al., 2018). The University of Sydney Page 76 Technical Facilities Key publications

1. Ebrahimkhani, S., Vafaee, F., 3. S. Hallal, S., Mallawaaratchy, D. Hallal, S., Wei, H., Lee, M.Y.T., M., Wei, H., Ebrahimkhani, S., Young, P.E., Satgunaseelan, Stringer, B. W., Day, B. W., Boyd, L., Beadnall, H., Barnett, M.H., A. W., Guillemin, G. J., Buckland, Shivalingam, B., Suter, C.M., M. E. & Kaufman, K.L. (2018). Buckland, M.E. & Kaufman, K.L. Extracellular vesicles released (2018). Deep sequencing of by glioblastoma cells stimulate circulating exosomal microRNA normal astrocytes to acquire a allows non-invasive glioblastoma tumor-supportive phenotype via diagnosis. NPJ Precision p53 and MYC signaling pathways. Oncology 2:28. Molecular Neurobiology. doi:

10.1007/s12035-018-1385-1 Technical Facilities 2. Hallal, S., Russell, B.P., Wei, H., Lee, M.Y.T., Toon, C.W., Sy, J., Shivalingam, B., Buckland, M.E. & Kaufman, K.L. (2018). Extracellular vesicles from neurosurgical aspirates identifies chaperonin containing TCP1 subunit 6A as a potential glioblastoma biomarker with prognostic significance. Proteomics, 19(1-2). doi:10.1002/ pmic.201800157 Key publications Page 77 Technical Facilities Microscopy

The Brain and Mind Centre’s

sydney.edu.au/brain-mind microscopy facilities provide researchers with access to sophisticated technology to observe diseases of the brain and mind at a micro level.

The microscopy facility based at the Brain and Mind Centre forms part of Sydney Microscopy and Microanalysis (SMM), the University of Sydney’s largest core facility, which is run by the Australian Centre for Microscopy and Microanalysis. This cross- Human neurones differentiated from neural stem cells. The cells have been stained with markers showing the nuclei of the neurones (blue) and their disciplinary research centre is networks (green and red). Experiments conducted using these neurones one of the most comprehensive hope to unravel the mechanisms of neurodegenerative diseases, such as Parkinson’s disease. This image was the winner of the NHMRC Science to microscopy centres in the world, Art 2019 Award. Provided by Jianqun Gao, PhD student, ForeFront Ageing and Neurodegeneration Team. with world-class instrumentation and technical expertise available for all researchers. An SMM-wide

Brain and Mind Centre Annual Report 2017-18 facility management booking system allows users to seamlessly book any microscopy platform across the Brain and Mind Centre, the Madsen building and the Charles Perkins Centre.

Over the past few years we have purchased new, state-of-the-art equipment, including a Leica DIVE multiphoton system, which will allow the 3D observation of complex biological processes occurring in live tissues.

The University of Sydney Human skin cells that have been reprogrammed and differentiated into neurones. The cells have been stained with markers depicting the nuclei of the neurones (blue), the connections between the neurones as a network (green), abnormal protein aggregates (yellow) and the mechanism of autophagy (red). The cells can be used as a tool to study neurodegenerative diseases. This image was awarded an Image of Distinction at the Nikon Small World 2018 Photomicrography Competition. Provided by Jianqun Gao, PhD student, ForeFront Ageing and

Page 78 Neurodegeneration Team. Technical Facilities Neurology Laboratory

The Brain and Mind Centre’s Neurology Laboratory is one of the world’s leading centres for diagnosis and research into nerve and muscle diseases.

A collaboration between the University of Sydney and Royal Prince Alfred Hospital, the Neurology Laboratory is a Technical Facilities state reference laboratory for peripheral nerve and muscle histopathology (NATA/RCPA Accreditation Number 2146). Established in the late 1960s, the laboratory was the first specialised neuromuscular pathology unit in Australia, and has maintained its position at the forefront of work in this specialisation.

The laboratory, managed by Dr Min- Xia Wang, Senior Principal Hospital Scientist at RPAH, holds one of the largest curated nerve and muscle archives in the world. This repository is an invaluable resource for research and teaching across brain and mind sciences. The laboratory has produced more than 300 original research publications and trained numerous PhD and Neurology Laboratory other higher-degree students.

In 2018, we validated a novel approach to the diagnosis of neuropathy using minimally invasive skin biopsy, a collaboration with the Mayo Clinic, and hope to begin offering this as clinically available tool in 2019. Page 79 Technical Facilities Key publications

1. Mathey EK, Garg N, Park SB, 3. Sutrave G, Maundrell A, Keighley

sydney.edu.au/brain-mind Nguyen T, Baker S, Yuki N, C, Jennings Z, Brammah Yiannikas C, Lin CS, Spies JM, S, Wang MX, Pamphlett R, Ghaoui R, Barnett MH, Vucic Webb CE, Stark D, Englert H, S, Pollard JD, Kiernan MC. Gottlieb D, Bilmon I, Watts MR. Autoantibody responses to Anncaliia algerae Microsporidial nodal and paranodal antigens Myositis, New South Wales, in chronic inflammatory Australia. Emerg Infect Dis. 2018 neuropathies. J Neuroimmunol. Aug;24(8):1528-1531. 2017 Aug 15;309:41-46. doi: 10.1016/j.jneuroim.2017.05.002. 4. Triplett JD, Pamphlett R, Wang MX, Yiannikas 2. Lechpammer, M., Martinez C. Anti-SRP associated Cerdeno, V., Hunsaker, M., necrotizing autoimmune Hah,M., Gonzalez, H., Tisch, myopathy presenting with S., Joffe, R., Pamphlett, R., asymptomatically elevated Tassone, F., Hagerman, P., et creatine kinase. Muscle Nerve. al. Concomitant occurrence 2018 Nov 29. doi: 10.1002/ of FXTAS and clinically defined mus.26388. [Epub ahead of sporadic inclusion body print] myositis: Report of two cases.

Brain and Mind Centre Annual Report 2017-18 Croatian Medical Journal, 2017, 58(4), 310-315. The University of Sydney Page 80 Lambert Initiative _

Exploring the medicinal potential of cannabinoid therapeutics. Lambert Initiative Lambert Initiative Page 81 Lambert Initiative Our core business

The Lambert Initiative for Cannabinoid Therapeutics, based at the Brain and Mind Centre, is a long-term research program exploring the medicinal potential of the cannabis plant. Our vision is to conduct the sydney.edu.au/brain-mind high-quality research required to discover, develop and optimise safe and effective cannabinoid therapeutics in Australia and beyond.

The Lambert Initiative was founded in 2015, Our activities span a wide spectrum of thanks to an unprecedented pledge of $33.7 basic science and clinical activities – from million to the University by Barry and Joy plant science to cellular and preclinical Lambert – the largest single gift in the history pharmacology to medicinal chemistry and of the University of Sydney. The Initiative drug discovery –with the ultimate goal of now provides national and international producing cannabinoid-based medicines and leadership in the science of medicinal ensuring their availability to patients. cannabinoids and in the discovery and development of cannabis-based medicines.

Advocacy and education

Brain and Mind Centre Annual Report 2017-18 In parallel with our scientific endeavours, For many patients and families, the future the Lambert Initiative also acts in an of medicinal cannabis is one of hope: hope advocacy and educational capacity, that legislation will change to make medical targeting consumers, health professionals cannabis and future cannabinoid drugs and politicians and influencing regulatory more accessible. Hope that attitudes change approaches and public health policy. to encourage practitioners to prescribe medicinal cannabis. A key aspect of the Lambert Initiative’s vision is to provide tangible scientific evidence to help translate hope into reality. The University of Sydney Page 82 Lambert Initiative Highlights

Methamphetamine addiction research Lambert Initiative scientists have recently researchers Professor Iain McGregor and shown that there is potential for Cannabidiol Associate Professor Jonathon Arnold, in (CBD) to be used in the treatment of collaboration with Associate Professor methamphetamine addiction. Jennifer Cornish at Macquarie University, recently published a paper in the Journal Methamphetamine, also known as “ice” or of Psychopharmacology (Hay et al., 2018 – “crystal meth”, is highly addictive, and people see key publications) showing that a single who develop a dependence on it find it very exposure to CBD reduced the motivation Lambert Initiative difficult to kick their habit. Binge use of to seek and consume methamphetamine methamphetamine is common, wherein users in rats. Moreover, CBD reduced relapse to repeatedly take the drug and do not eat or methamphetamine use; this is important sleep for days. Long-term use is particularly as drug relapse is crucial in explaining the problematic because it is associated with chronic nature of drug addiction. anorexia, severe dental problems (“meth mouth”), aggression and paranoid psychosis The team is now exploring the possibility of (hallucinations and delusions). The use mounting a clinical trial assessing the relative of methamphetamine by truck drivers is success of using CBD in the treatment of associated with road fatalities. methamphetamine addicts.

There are few treatment options available to curb methamphetamine use or prevent relapse into drug use. Lambert Initiative Highlights Page 83 sydney.edu.au/brain-mind

Professor Iain McGreggor, Dr Michael Bowen and the research team

World Health Organisation review and recommendations Associate Professor Jonathon The 40th ECDD meeting attended Arnold was one of four cannabis by Associate Director Associate experts selected world-wide Professor Arnold was a historic to assist the World Health meeting for two reasons: Organisation (WHO) at their 40th −− It marked the first time in Brain and Mind Centre Annual Report 2017-18 meeting of the Expert Committee history that the WHO reviewed of Drug Dependence (ECDD) in the risks and benefits of the Geneva in June 2018. This meeting cannabis plant and cannabis- may have huge ramifications for related substances. the restricted status of cannabis −− It recommended that under international drug control cannabidiol not be subjected treaties, as this committee makes to international drug control. rescheduling recommendations to the United Nations which are then At the time of writing, the voted on by member states. recommendations made will be voted on at the upcoming UN’s Currently, the cannabis plant Commission of Narcotic Drugs and extracts are included in the in Vienna. If the UN adopts the most restricted schedules of the recommendations, this will end world’s international drug-control international cannabis prohibition treaties. For example, cannabis is and ease country-level restrictions included in the Single Convention on medicinal cannabis and the use The University of Sydney on Narcotic Drugs in schedules of cannabis for scientific research. I and IV, which deems cannabis to be highly liable to abuse and particularly dangerous. Page 84 Cannabis as Medicine Survey In 2016, researchers at the Lambert Initiative −− A range of side effects were also conducted the first Australia-wide survey identified, including increased of individuals self-reporting the use of appetite, drowsiness, eye irritation, cannabis for medical reasons: the Cannabis lethargy, and memory impairment. As Medicine Survey 2016 (CAMS:16). −− People also reported concerns stemming from the illegal status of This survey captured the experiences of their cannabis use, citing concerns 1744 Australians before the implementation about employment, irregular access of new regulations in October 2016, and so to cannabis and the highly variable represents a ‘before’ snapshot of medical quality of cannabis accessed illegally. cannabis use in Australia. Representing the −− Most people expressed a strong largest survey of medical cannabis users in preference for medical cannabis Australia, the CAMS:16 results were published to be integrated into mainstream in the Medical Journal of Australia in healthcare and for products to meet August 2018. quality and safety standards. Lambert Initiative The research identified a number The research team repeated the survey in of key findings: 2018 (publication pending) and will do so −− Cannabis was most commonly used for again in 2020, to look at how patterns of chronic pain, mental health (anxiety, use have changed since new regulations depression and post-traumatic stress have taken effect. CAMS:18 and CAMS:20 disorder), sleep and neurological will provide us with a unique opportunity conditions. Medical cannabis was to examine the impact of the regulatory largely illicitly sourced and used and community changes regarding medical by inhaled routes, such as “bongs/ cannabis over time. water pipes” (42 percent) or “joints” (20 percent), although most people indicated they would prefer to use safer approaches, such as oral routes. −− Overall, people reported that their cannabis use had been effective in helping to manage their health conditions.

GP Survey

In late 2017, the Lambert Initiative conducted As the ABC reported in July 2018, the survey Highlights a survey of 640 Australian general results indicate a clear need for GPs to be practitioners (GPs) regarding the use of more educated about medicinal cannabis, medicinal cannabis in patient treatment. in addition to being authorised to prescribe The results, which were published in the it. Most doctors said they felt they did not British Medical Journal Open (Karanges et have enough knowledge about the drug to be al., 2018 – see key publications) revealed that comfortable discussing it with patients. GPs strongly support prescribing medical cannabis to help people cope with cancer- related pain, palliative care and epilepsy. Additionally, almost two thirds (61.5 percent) of the GPs surveyed have had patients ask about the drug. Page 85 Paediatric epilepsy (PELICAN) study sydney.edu.au/brain-mind This study examined the experiences and had trialled more anticonvulsants than and attitudes of parents of children with those that had never received cannabis epilepsy on the use of cannabis oils to treat extracts. The team also discovered there was their child’s illness. The team conducted high variability in the cannabinoid content interviews with families of children with and profile of cannabis extracts. Contrary to diverse forms of epilepsy to explore their families’ expectations, many samples did not attitudes towards and experiences with, contain CBD, while THC was present in nearly using cannabis extracts, including families every sample. who have tried and stopped using medicinal cannabis, and families who had never used These findings highlight profound variation in cannabis-derived treatments. For those the illicit cannabis extracts being currently using cannabis, extracts were analysed for used in Australia and warrant further cannabinoid content. investigations into the value of cannabinoids, either alone or in combination, in epilepsy. This study produced some interesting results, including that children given cannabis extracts tended to have more severe epilepsy Brain and Mind Centre Annual Report 2017-18 The University of Sydney Page 86 Lambert Initiative Grants awarded

Associate Professor Jonathan Arnold Key publications has been awarded a National Health and Medical Research Council (NMHRC) Project 1. Hay, G., Baracz, S., Everett, N., Roberts, Grant for the preclinical development J., Costa, P., Arnold, J., McGregor, of cannabis-derived medicines for I., Cornish, J. (2018). Cannabidiol drug-resistant epilepsy. Many childhood treatment reduces the motivation to epilepsies are refractory to current self-administer methamphetamine and treatment options and patients have a methamphetamine-primed relapse in large seizure burden, often including rats. Journal of Psychopharmacology, a reduced lifespan and developmental 32(12), 1369-1378. Lambert Initiative delays. Through this project, our aim is to further develop our understanding of the 2. Karanges, E., Suraev, A., Elias, N., role of the endocannabinoid system in Manocha, R., McGregor, I. (2018). childhood epilepsy and undertake preclinical Knowledge and attitudes of Australian development of candidate cannabinoids general practitioners towards medicinal as anticonvulsants. cannabis: a cross-sectional survey. BMJ Open, 8(7), e022101.

3. Suraev, A., Todd, L., Bowen, M., Allsop, D., McGregor, I., Ireland, C., Lintzeris, N. (2017). An Australian nationwide survey on medicinal cannabis use for epilepsy: History of antiepileptic drug treatment predicts medicinal cannabis use. Epilepsy and Behavior, 70, 334-340.

4. Suraev, A., Lintzeris, N., Stuart, J., Kevin, R., Blackburn, R., Richards, E., Arnold, J., Ireland, C., Todd, L., Allsop, D., McGregor, I. (2018). Composition and Use of Cannabis Extracts for Childhood

Epilepsy in the Australian Community. Grants awarded Scientific Reports, 8(1), 28127. Page 87 Brain and Mind Centre Our donors

Our goal is to translate research into real-world outcomes that improve patient care and treatment, transforming the lives of the individuals and families affected by disorders of the brain and sydney.edu.au/brain-mind mind. This transformative work would not be possible without the support of our donors.

As the multidisciplinary home for next five to 10 years, in particular, mental health and neuroscience will transform knowledge and at the University of Sydney, we are practice, ultimately helping to part of an institution with a proven improve outcomes for patients track record of research excellence, and their families. Philanthropy which benefits communities near will remain an essential part of our and far. success and ability to realise these breakthroughs and discoveries. Our donors have a profoundly significant impact on advancing We deeply value relationships mental health and neuroscience with all supporters and partners research. One hundred per cent who understand the role that Brain and Mind Centre Annual Report 2017-18 of donations received go directly high-quality, multidisciplinary to funding research that may and translational research plays otherwise not have been supported alongside clinical services in driving through traditional grant schemes. real outcomes. The impact of Over the past two years, we have their support is immeasurable and received more than $13 million in increasingly pivotal to our success. donations to support research, scholarships and services across To find out more about how you can child development, youth mental support our work, please visit health and addiction and ageing −− sydney.edu.au/ and neurodegeneration. brain-mind/donate

There has never been a more promising time to support mental health and neuroscience research. The advancements that will emerge in this field over the The University of Sydney Page 88 Brain and Mind Centre Supporting research

As government funding continues to decrease, philanthropy is critical in order for us to make major research breakthroughs and health advances. A generous gift of $240,000 has enabled the Frontier Research Group to establish a vital Research Assistant position to accelerate their crucial work in improving Frontotemporal Dementia diagnosis, finding

its cause, developing effective Brain and Mind Centre treatments for the condition and working towards a cure.

“Without this generous gift, we would not have been able to hire James, who offers the perfect balance between the clinical and the technical. He is improving and streamlining all our systems,” explained Professor Oliver Piguet, Co-Director of the Frontier team.

“He ensures that the practice runs to its best, allowing the team to be dynamic and our research translational. He plays a key role in driving our research agenda forwards at a quicker pace than would have been otherwise possible.

“Gifts like this not only have a Supporting research Supporting research profoundly positive impact on our patients and their families, but on the future health of all Australians.” Page 89 Brain and Mind Centre Supporting early-career researchers sydney.edu.au/brain-mind

EMCR L-R Dr Rachel Tan, Dr Loren Mowszowski, Dr Petra van Nieuwenhuijzen, Dr Samuel Banister (L-R. Not pictured Dr Kaylena Engoetz Martens and Dr Rebekah Ahmed)

Philanthropy is vital to funding our early- “Lenity is honoured to be a partner

Brain and Mind Centre Annual Report 2017-18 career researchers (ECRs). In the field of in this vital area of research”, Geoff mental health and neuroscience, ECRs Henry from Lenity Australia said. “This often struggle to gain the vital research donation compliments our portfolio of experience necessary to win grant humanitarian and medically focused funding. A philanthropic gift allows ECRs projects in Australia and Oceania.” to continue to work in their chosen field without having to turn to other research Professor Matthew Kiernan, Co-Director areas where grant funding is perhaps of the Brain and Mind Centre, says more easily available. philanthropy is a vital avenue of support for research. “Gifts like this one from Lenity Australia, for example, has Lenity Australia allow us to attract the donated $1.25 million to support a brightest talent and expand into new five-year research fellowship, the areas of focus, significantly contributing Lenity Research Fellow, in the field of to our already important work in ageing neurodegenerative diseases at the Brain and neurodegeneration.” and Mind Centre. The University of Sydney Page 90 Brain and Mind Centre Thanks to our donors

The Brain and Mind Centre wishes Roussel, Ms Catherine Abbott, Mr Kildare Road Medical Centre, Lenity to thank all of our donors. Your Charles Reynolds, Mrs Christine Australia, Mr Leslie P Pongrass, Mr generosity keeps our work possible Windeyer, ClubsNSW, , Colorectal Luke Watson, Ms Maria Valos, Dr and together we raised over $13 Surgical Society of Australia and Marion G Maxwell, Mr Marty Shaw, million in donations between New Zealand, Conversely, Mr The Michael J. Fox Foundation for January 2017 and December 2018. Craig Whitworth, Cure for MND Parkinson’s Research, Mr Michael Foundation Inc, Mrs Cveta Lillyman, R Johnston, Mr Miles Prosser, The No gift is too small and we welcome Mr David E Landa OAM, Ms Debbie Mill House Foundation, Motor contributions of any size. We wish Seidler, Diamond Blue Financial Neurone Disease Research Institute to particularly thank the following Services, Ms Diane Chaffey, Ms of Australia Inc., The Negri Family, people, who donated $1000 Elaine Chang, Dr Eleanor Jew, Ms Mr Otto and Mrs Judy Appenzeller,

or more. Our thanks also go to Eleanor Sydney-Jones, Estate Mr Paul Rosin, Mr Peter J Burgess, Brain and Mind Centre our donors who wish to remain of the Late Christopher J Wood, Mr Peter McAuliffe, Mrs Rae Cottle, anonymous and to all those who Fireglobes Australia, Fredmarch Pty Mr Robert Phillips, Mrs Robyn have contributed over the last Ltd, Future Generation Investment Winifred Smith, Dr Roslyn Jolly, two years. Company, Ms Gail Hayman, The Shake It Up Australia Foundation, Goodridge Foundation, Harper Ms Silvana d’Iapico-Bien, St Mr Alastair Griffin, Dr Alexander Bernays Charitable Trust, Mrs Vincent’s Hospital Sydney Limited, Bela Leslie Hunyor, Alleasing Pty Helen Breekveldt, Mrs Hilary St Vincent’s Private Hospital Ltd, Australian & New Zealand Marion Cairns, Mr Ian William Sydney, Dr Steven K C Lee, Mrs Association of Neurologists, Mrs Jew, Ironshore Australia Pty Ltd, Susan Hauser, Dr Suzanne Lewis, Dr Annabel Williamson, Mrs Anne Mrs Jacqueline A Hiller, Mr James Terence J Wiesner, The University Osborne Sullivan, Balverona Pty Rebbeck, Ms Jane Dean, Mr Jeff of Sydney USA Foundation Inc, Ltd, Bluesand Foundation Pty Hauser, Dr Jill M Hawker, The Jim Ms Vanessa Pearson, Dr Vincent Ltd, Dr Brian John Shaw OAM, McIntyre Foundation, Mr Joseph V Phung, Mr William Sweeney, Ms Cara Chriqui, Mrs Carole Vucetic, JR Darling Foundation, The Yulgilbar Foundation. Thanks to our donors Page 91 Brain and Mind Centre Our teams

Our unique teams consist of academics, researchers, students and professional staff. They are the lifeblood of Brain and Mind Centre. We acknowledge and give thanks for sydney.edu.au/brain-mind their tireless hard work, diligence and dedication to their research, which can, and is, changing the world.

Child Neurodevelopment and Mental Health Team Academic staff −− Professor Alistair McEwan, Students −− Professor Adam Guastella, Ainsworth Chair of −− Marilena Demayo, PhD Michael Crouch Chair in Technology and Innovation student and RA Child and Youth Mental −− Associate Professor Suncica −− Shrujna Patel, PhD student Health, Team Lead Lah, Clinical Neuropsychologist −− Zahavva Ambarchi, PhD student −− Professor Russell Dale, −− Associate Professor Joanne −− Rinku Thapa, PhD student Head – Kids Neuroscience Arciuli, ARC Future Fellow, Centre, Children’s Hospital Leader of the Children, −− Veth Guevarra, PhD Student at Westmead, Team Lead Family and Disability Work −− Kavitha Kothur, PhD Student −− Professor Nadia Badawi, Stream – Centre for Disability −− Samantha Joplin, DCP/ Macquarie Group Foundation Research and Policy PhD student Professor and Chair of Cerebral −− Associate Professor Michael −− Elizabeth Stewart, DCP/ Brain and Mind Centre Annual Report 2017-18 Palsy, University of Sydney Kohn, Paediatrics & Child Health, PhD student Children’s Hospital at Westmead −− Professor Fernando Calamante, −− Belinda Kirley, DCP/PhD student Director – Sydney Imaging −− Associate Professor Sandra −− Cecilia Law, MCP/PhD student Core Research Facility Cooper, NHMRC Career −− Bethanie Menzies, PhD student −− Professor Natasha Nassar, Development Fellow, Paediatrics Chair in Translational & Child Health, Children’s −− Mary Burns, PhD student Childhood Medicine – Financial Hospital at Westmead −− Karishma Rajan Menon, Markets Foundation −− Associate Professor MCP student −− Professor Iona Novak, Head Natalie Silove, Head –Child −− Vera Yeo, MCP student Development Unit, Children’s of Research - Cerebral −− Dr Natalie Phillips, Hospital at Westmead Alliance Research Institute, Honorary Associate of the University of Sydney −− Dr Antoinette Redoblado-Hodge, School of Psychology, The −− Professor Ralph Nanan, Clinical Neuropsychologist, University of Sydney Head – Child Development Unit, Professor of Paediatrics & Child −− Karlie Hidalgo, PhD student Health, Director – Charles Children’s Hospital at Westmead −− Samantha Joplin, DCP/ Perkins Centre Nepean −− Associate Professor Daniel PhD student The University of Sydney −− Professor Joshua Burns, Catchpoole, Group Leader Professor of Paediatric –Biospecimens Research and Neuromuscular Rehabilitation, Tumour Bank, Children’s Cancer Associate Dean Research Research Unit, Children’s Hospital at Westmead Page 92 Professional Staff −− Dr Shekeeb Mohammad, Senior −− Dr Tegan Cheng, Postdoctoral −− Indra Sadeli, Research Assistant Lecturer and Staff Specialist Biomedical Engineer Paediatric Neurology −− Izabella Pokorski, Clinical −− Dr Gareth Roberts, Postdoctoral Research Manager −− Dr Cathrin Rohleder, Researcher, Psychology Postdoctoral Fellow, Youth −− Dr Cathy Morgan, Senior Associates and Collaborators Mental Health Team – Brain Research Fellow, Cerebral and Mind Centre −− Dr Michael Villeneuve, Palsy Alliance Leader – Disability-Inclusive −− Dr Christine Song, Autism Clinic −− Dr Hayley Smithers-Sheedy, Community Development for Translational Research Senior Research Fellow, work stream, Centre for – Brain and Mind Centre Cerebral Palsy Alliance Disability Research and Policy −− Dr Ingrid Honan, Postdoctoral −− Dr Maria McNamara, Research −− Professor Nick Glozier , Professor Fellow, Neuropsychologist, Manager, Cerebral Palsy Alliance Cerebral Palsy Alliance of Psychological Medicine −− Ms Alice Tricks, Research −− Professor Marc Stears, −− Dr Samantha Lain, NHMRC Assistant, Cerebral Palsy Alliance Early Career Fellow, Perinatal Director – Sydney Policy Lab −− Ms Olivia Finemore, Research and Child Population −− Dr Lamiae Azizi, Deputy Assistant, Cerebral Palsy Alliance Health Research, Children’s Director – Centre for Hospital at Westmead −− Dr Micah Goldwater, Translational Data Science Psycholinguistics Brain and Mind Centre −− Dr Basiliki Lampropoulos, −− Associate Professor Fabienne Developmental Specialist, Brilot-Turville, Principal Research Paediatrian, Nepean Hospital Fellow, Brain Autoimmunity Group –Kids Research, −− Dr Oren Civier, Postdoctoral Children’s Hospital at Westmead Research Associate, Imaging −− Dr Hannah Jones, −− Dr Paula Bray, Postdoctoral Paediatric Neurologist Occupational Therapist

Youth Mental Health & Technology Academic staff −− Professor Sharon Naismith, Students −− Professor Ian Hickie, Senior Neuropsychologist −− Joanne Carpenter, PhD student Program Leader −− Associate Professor Louise −− Jacob Jeffrey Crouse, −− Ms Tracey Davenport, Head Nash, Post-graduate Education PhD student of Technology stream −− Professor Niels Buus, −− Ashleigh Tickell, PhD student Suicide intervention −− Dr Shane Cross, Head of Clinical −− Jeanne Gehue, PhD student Services Development Stream −− Professor Sally Cripps, −− Ange Weinrabe, MPhil student −− Professor Markus Leweke, Bayesian statistics

−− Sophia Bogaty, MPhil student Our teams Chair in Youth Depression −− Professor Jim Lagopoulos, Studies; Cannabidiol Research Neuroimaging expertise −− Joanne Carpenter, PhD student −− Associate Professor Dagmar −− Professor Richard Banati, −− Ashlee Grierson, PhD student Koethe, Clinical Trials; Neuroimaging expertise −− Peta Eggins, PhD student Cannabidiol Research −− Professor Cheryl −− Casey Paquola, PhD student −− Professor Caroline Jones, Developmental −− Laura Ospina-Pinillos, Hunt, Youth Bullying inflammatory processes PhD student −− Dr Frank Iorfino, Research Fellow −− Professor Colm Harmon, −− Vanessa Cheng, PhD student Youth mental wealth −− Associate Professor Elizabeth −− Cate McHugh, PhD student Scott, Mood disorders; −− Professor John Buchanan, −− Kate Chitty, PhD student Neuroimmunology Working life transitions −− Professor Adam Guastella, −− Dr Alyssa Milton, Senior Clinical Researcher Postdoctoral Researcher Page 93 Professional Staff −− Associate Professor −− Django White, James Scott, UQ, Research Coordinator −− Associate Professor Victor and Data Manager Storm, NSW Health , −− Natalia Zmicerevska, −− Anna Lee, NSW Health , Clinical Research Officer −− Associate Professor −− Chloe Wilson, David Hawes, USYD, PhD Student Research Assistant −− Dr Alyssa Milton, USYD, −− Alissa Nichles, −− Professor Maree Teesson, USYD, Clinical Research Officer −− Associate Professor sydney.edu.au/brain-mind −− Dr Cathrin Rohleder, Maree Abbott, USYD, Research Admin Officer −− Professor Russell Dale, USYD, −− Dr Christine Song, −− Professor Anthony Harris, USYD, Postdoctoral Research Fellow −− Associate Professor Kay Associates and Collaborators Bussey, Macquarie U, −− Professor Nick Martin, QIMR, −− Professor Simon Carlile, USyd, −− Professor Paul Amminger, UMelb, −− Professor John Mendoza, ConNetica Consulting −− Associate Professor Tim Slade, UNSW, −− Dr Stefan Blum, UQ, Brain and Mind Centre Annual Report 2017-18 The University of Sydney Page 94 The ForeFront Ageing and Neurodegeneration team Academic Staff −− Professor Cindy Lin, The −− Dr Rachel Tan, NHMRC Dementia −− Professor Glenda Halliday, Kam Ling Barbara Lo Chair in Research Fellow, Dementia and NHMRC Senior Principal Neurodegenerative Disorders, Movement Disorders Laboratory Research Fellow & Professor of ForeFront MND Group −− Dr Daniel Roquet, Postdoctoral Neuroscience, ForeFront Team −− Professor Jillian Kril, Professor of Research Associate, Frontier Leader, Leader of Dementia and Neuropathology, Dementia and Frontotemporal Dementia Movement Disorders Laboratory movement disorders laboratory Research Group −− Associate Professor John −− Professor Michael Kassiou, −− Dr Annica Barcenilla-Wong, Kwok, Leader of Genetics Professor of Medicinal Postdoctoral Reseach Associate, and Epigenetics Group Chemistry, Neuroimaging Healthy Brain Ageing −− Professor Matthew and drug design associate −− Dr Sivaraman Purushothuman, Kiernan, Bushell Chair −− Professor Michael Fulham, NHMRC Dementia Research of Neurology, Leader of Neurologist and RPAH Director of Fellow, Dementia and ForeFront Motor Neurone Imaging, Neuroimaging associate Movement Disorders Lab Disease Research Group −− Associate Professor Scott −− Dr Surabhi Bhatia, NHMRC −− Professor John Hodges, Kim, Dementia and Movement Dementia Research Fellow,

Professor of Cognitive Disorders Laboratory Dementia and Movement Brain and Mind Centre Neurology, Co-leader of −− Dr Carol Dobson-Stone, Senior Disorders Laboratory Frontier Frontotemporal Research Fellow, Genetics −− Dr Michael Lee, OSMR Dementia Research Group and Epigenetics Group Postdoctoral Fellow, −− Professor Olivier Piguet, −− Dr Nicholas Dzamko, Senior ForeFront MND Group NHMRC Senior Research Research Fellow, Dementia and −− Dr William Huynh, Postdoctoral Fellow & Professor of Movement Disorders Laboratory Fellow, ForeFront MND Group Neuropsychology, Co-leader −− Dr Yuhong Fu, Research Fellow, −− Dr Jose Manuel Matamala, of Frontier Frontotemporal Dementia and Movement Postdoctoral Fellow , Dementia Research Group Disorders Laboratory ForeFront MND Group −− Professor Simon Lewis, NHMRC −− Dr Susanna Park, NHMRC −− Dr Emma Devenney, Postdoctoral Dementia Research Fellow & CJ Martin Fellow, Fellow, ForeFront MND Group Professor of Cognitive Neurology, ForeFront MND Group Leader Clinical Parkinson’s −− Dr Emily Mathey, Research disease and dementia with −− Associate Professor Fellow, ForeFront MND Group Lewy bodies research group Muirrean Irish, ARC Future −− Dr James Burrell, NHMRC Early Fellow, Frontier Group −− Associate Professor Career Fellow, Frontier Group Kay Double, Leader of −− Dr Eleanor Drummond, Bluesand −− Dr Rebekah Ahmed, NHMRC Neurodegeneration Laboratory Fellow in Alzheimer’s Disease Early Career Fellow, Frontier −− Professor Sharon Naismith, −− Dr Jin-Sung Park, Senior & ForeFront MND Group Professor of Neuropsychology, Research Fellow, Genetics −− Dr Cristian Leyton Moscoso, of Parkinson’s Disease

Leader of Healthy Brain NHMRC Dementia Research Our teams Ageing Research Program −− Dr Kishore Kumar, Clinical Fellow, Frontier group −− Professor Carolyn Sue, Senior Lecturer, Genetics −− Dr Fiona Kumfor, NHMRC Professor of Neurogenetics, of Parkinson’s Disease Dementia Research Leader of Neurogenetics of −− Dr Mac Shine, NHMRC CJ Fellow, Frontier group Parkinsons Disease research Martin Fellow, Dementia and −− Dr Ramon Landin-Romero, −− Professor Steve Vucic, Movement Disorders Laboratory Research Fellow, Frontier group Professor of Neurology, −− Dr Zac Chatterton, Lecturer, −− Dr Claire O’Callaghan, NHMRC ForeFront MND Group Dementia and Movement CJ Martin Fellow, Clinical −− Associate Professor Clement Disorders Laboratory Parkinsons and Dementia Loy, Associate Professor of −− Dr Shelley Forrest, Postdoctoral with Lewy Bodies group Clinical Epidemiology and Research Associate, −− Dr Ryan Davis, NHMRC Early Cognitive Neurologist Dementia and Movement Career Fellow, Genetics Disorders Laboratory of Parkinson’s Disease Page 95 −− Dr Brian Koentojoro, −− Dr Neil Simon, PhD −− Karl Aoun, PhD student, Research Fellow, Genetics student & RO Neurologist, Neurodegeneration Lab of Parkinson’s Disease ForeFront MND Group −− Terence Wong, Honours student, −− Dr Ariandna Recasens, −− Tim Howells, PhD Student Neurodegeneration Lab Research Fellow, Genetics & RO Neurophysiologist, −− Nathan Cross, PhD student, of Parkinson’s Disease ForeFront MND Group Healthy Brain Ageing −− Dr , Guatam Wali, Associate −− Nidhi Garg, PhD student −− Antonia Carroll, PhD Lecturer, Genetics of & RO Neurophysiologist, Student & Neurologist, Parkinson’s Disease ForeFront MND Group ForeFront MND Group −− Dr Kaylena Ehgoetz Martens, −− Jashelle Caga, PhD student, −− Jasmin Galper

sydney.edu.au/brain-mind Sydney Postdoctoral Research ForeFront MND Group −− Jared Katzeff Fellow, Clinical Parkinsons and −− Dr Parvathi Menon, PhD student −− Lulu Liu dementia with lewy bodies group & staff specialist neurologist, −− Dr Katherine Phan, Postdoctoral ForeFront MND Group −− Zhe Long research Fellow, Clinical −− Nimeshan Geevasinga, PhD −− Kristin Economou Parkinsons and dementia student, ForeFront MND Group −− Amelia Jerram with Lewy bodies group −− Rosi Hutchings, PhD −− Jennifer Lee −− Dr Shantel Duffy, NHMRC student, Frontier −− Dev Nathani Dementia Research Fellow, −− Sherry Chen, PhD Healthy Brain Ageing −− Isabel Paniak student, Frontier −− Dr , Angela D’Rozario, NHMRC −− Thuc Hao Quang −− Nikki-Anne Wilson, PhD Dementia Research Fellow, −− Omar Shadid student, Frontier Healthy Brain Ageing −− Jessica Strudwick −− Sicong Tu, PhD student, Frontier −− Dr Camilla Hoyos, NHMRC −− Tamara Paulin Dementia Research Fellow, −− Stephanie Wong, PhD −− Amr Abdeen Healthy Brain Ageing student, Frontier −− Claire O’Connor, PhD −− Dr Loren Mowszowski, NHMRC Professional Staff Dementia Research Fellow, student, Frontier −− Tenielle Clinch, Genetic Healthy Brain Ageing −− Jennifer Szeto, PhD student,

Brain and Mind Centre Annual Report 2017-18 Councillor, Neurogenetics Clinical Parkinsons and dementia and Epigenetics Students with Lewy Bodies Group −− Elle Elan, Genetic Councillor, −− Noman Bakhshi, PhD student, −− Christina Liang, PhD student, Neurogenetics and Epigenetics Dementia and movement Genetics of Parkinsons disease −− Cassandra Kaizik, Occupational disorders Laboratory −− Nick Blair, PhD student, Genetics therapist, Frontier −− Jianqun Gao, PhD student, of Parkinsons disease −− Heidi Cartwright, ForeFront Dementia and movement −− Kate Ahmad, PhD student, Research Program disorders Laboratory Genetics of Parkinsons disease Coordinator, ForeFront −− Diba Rastegar, PhD student, −− Christine Wools, PhD student, −− Kelly Nicholas, Donor Dementia and movement Genetics of Parkinsons disease disorders Laboratory Coordinator, Dementia and −− Jason Gu, PhD student, Genetics Movement Disorders Laboratory −− Guinevere Lourenco, PhD of Parkinsons disease student, Dementia and −− Mic Cartwright, Full Stack −− Isabel Yeap, PhD student, movement disorders Laboratory Developer, Dementia and Genetics of Parkinsons disease Movement Disorders Laboratory −− Tony Hsiao, PhD student, −− Benjamin Trist, PhD student, Dementia and movement −− Emma McCormack, Participant Neurodegeneration Lab The University of Sydney disorders Laboratory coordinator, Dementia and −− Sian Genoud, PhD student, Movement Disorders Laboratory −− Ye Zhao, PhD student, Neurodegeneration Lab Dementia and movement −− Nicole Mueller, Donor disorders Laboratory −− Kathryn Matthews, PhD student, coordinator, Dementia and Neurodegeneration Lab Movement Disorders Laboratory −− Dr Thanuja Dharmodosa, PhD student & RO Neurologist, −− Eurwin Suryana, PhD student, −− Marianne Hallupp, Laboratory ForeFront MND Group Neurodegeneration Lab Manager, Dementia and Page 96 Brain and Mind Centre

−− Movement Disorders Laboratory Nurse, ForeFront MND Group −− Ashneta Kumar −− Eve Jary, Research Assistant, −− David Foxe, Frontier −− Bell Lee Dementia and Movement Coordinator, Frontier −− Hongyun Li Disorders Laboratory −− Melissa Abela , Frontier Donor −− Chengtao Liang −− Nikita He, Research Assistant, Coordinator, Frontier −− Andrew McKinnon Dementia and Movement −− Angela Scharfenberg , −− Sau Chi Cheung Disorders Laboratory Research Assistant, Frontier −− Dinusha Fernando −− Dr Farzaneh Atashazm, Research −− Sarah Homewood, Clinic Assistant, Dementia and Administrative Assistant, Frontier −− Irene Mukwindidza Movement Disorders Laboratory −− Jessica Hazelton, Research −− Lauren Ryden −− Gayaturi Perera, Research Assistant, Frontier −− Anthea Staines Assistant, Dementia and −− Annu Mothakunnel, Research −− Marilla Pereira Movement Disorders Laboratory Assistant, Frontier −− Gayathri Perera −− Shikara Keshiya, Research −− Hannah Timmons, Research Assistant, Dementia and −− Alena Rahmanovic Assistant, Frontier Movement Disorders Laboratory −− Nicollette Thornton −− Tiffany Li, Research −− Dr Yue Yang, Research Assistant, −− Adam Bentvelzen Assistant, Frontier Dementia and Movement Disorders Laboratory −− Cynthia Murray, Research Associates and Collaborators Our teams Assistant, Frontier −− Eleanor Ramsey, MND −− Dr Karen Crawley, General Research Coordinator, −− Nathan Bradshaw, Research Practitioner, Genetics of ForeFront MND Group Assistant, Frontier Parkinson’s disease −− Julie Labra, MND −− Mirelle D’Mello, Research −− Dr Jerome Ip, Neurologist, Research Coordinator, Assistant, Frontier Healthy Brain Ageing ForeFront MND Group −− Deborah Hammond, Parkinsons −− Dr Yu-ichi Noto, Neurologist −− Dianne Tyson, MND Disease Clinic Specialist Nurse, and visiting scholar, Administrative Assistant, Clinical Parkinsons and Dementia ForeFront MND Group with Lewy Bodies Research ForeFront MND Group −− Dr Nick Cordato, Geriatrician, −− Elizabeth Highton-Williamson, −− Veronica Cottom, Research neurologist & visiting MND Donor Coordinator, Assistant and Laboratory scholar, Frontier ForeFront MND Group Manager, Neurodegeneration Laboratory

−− Margie Zoing, MND Clinical Page 97 External Collaborators −− Professor Amy Brodtmann, −− Professor John Magnussen, −− Professor Stanley Prusiner, Professor of Stroke and Professor of Neuropathology, Professor of Neurology and Cognitive Neuroscience, ForeFront imaging Biochemistry, ForeFront Frontier Frontotemporal −− Professor John Mattick, Dementia and Movement Dementia Research Group Professor of Molecular Biology, Disorder Laboratory −− Professor Dominic Rowe, ForeFront RNA biology −− Professor Ian Blair, Professor Professor of Neurology, −− Professor Antony of Neuroscience, ForeFront ForeFront Motor Neurone Cooper, Professor of Neurogenetics and Epigenetics Disease/Parkinson’s Disease Neuropathology, Forefront Research Group −− Professor Ian McKeith, Neurodegeneration Research Professor of Old Age Psychiatry, Laboratory/RNA biology

sydney.edu.au/brain-mind −− Professor Rosa Rademakers, Professor of Neuroscience, ForeFront Parkinson’s Disease −− Dr Dominic Hare, Chancellor’s ForeFront Neurogenetics and and Dementia with Lewy Postdoctoral Research Fellow, Epigenetics Research Group Bodies Research Group Forefront Neurodegeneration −− Dr Jonathon Rohrer, MRC −− Professor Lars Ittner, Research Laboratory Clinician Scientist, ForeFront Professor of Medicine, −− Associate Professor Frontier Frontotemporal ForeFront animal modelling David Finkelstein, Senior Dementia/Neurogenetics −− Professor Victor Villemagne, Research Fellow, Forefront and Epigenetics Professor of Medicine, Neurodegeneration ForeFront imaging Research Laboratory

Sydney Neuroimmunology

−− Associate Professor −− Dr John Parratt, Senior Lecturer Fabienne Brilot-Turville, −− Emeritus Professor John Pollard, Principal Research Fellow Professor of Neurology −− Associate Professor Michael −− Associate Professor Barnett, Neurologist

Brain and Mind Centre Annual Report 2017-18 Geoffrey Herkes, Clinical −− Professor Matthew Kiernan, Associate Professor Bushell Chair of Neurology −− Associate Professor Sean −− Professor Russell Dale, Riminton, Clinical Senior Paediatric Neurologist Lecturer and Staff Specialist, −− Professor David Brown, Clinical Immunology Immunologist −− Professor Steve Vucic, −− Professor Ian Hickie, Neurologist Professor of Psychiatry −− Professor David Booth, −− Dr Stephen Adelstein, Principal Research Fellow Clinical immunologist −− Associate Professor Stephen Reddel, Neurologist −− Dr Melanie Wong, Senior staff specialist in paediatric allergy and immunology

The University of Sydney −− Professor Dianne Campbell, Chair of Paediatric Allergy and Clinical Immunology, Children’s Hospital, Westmead −− Associate Professor Stephen Fuller, Associate Dean and Head of School, University of

Page 98 Sydney School of Medicine Sleep and Circadian Biology team Academic Staff −− Dr Dr Negar Memarian, Associates and Collaborators, −− Professor Sharon Naismith, Research Fellow, Woolcock −− Associate Professor Brandon NHMRC Dementia Fellow & Institute of Medical Research Yee, Senior Staff Specialist, Leonard P Ullman Chair in −− Dr Natalie Phillips, Postdoctoral Clinical Associate Professor RPA Psychology, Team Lead Research Associate, Paediatric −− Associate Professor Keith Wong, −− Professor Ron Grunstein, Neuropsychology Senior Staff Specialist, Clinical NHMRC Senior Principal −− Dr Kaylena Ehgoetz Martens, Associate Professor RPA Research Fellow, Team Lead Postdoctoral Research Fellow −− Associate Professor Delwyn −− Professor Simon Lewis, NHMRC Bartlett, Clinical Associate Dementia Research Fellow Students Professor Woolcock & Professor of Cognitive −− Joanne Carpenter, PhD Student −− Associate Professor Neurology, Team Lead −− Jonathon Pye, PhD Student Bandana Saini, NHMRC −− Professor Ian Hickie, NHMRC −− Yun Hwang, PhD Student TRIP Fellow, Woolcock Senior Principal Research Fellow −− Carla Harountonian, PhD Student −− Associate Professor −− Professor Glenda Halliday, Suncica Lah, Clinical −− Johannes Michaelian, NHMRC Senior Principal Neuropsychology, Paediatrics

PhD Student Brain and Mind Centre Research Fellow and −− Professor Rafael Calvo, ARC −− Anna Mullins, PhD Student Professor of Neuroscience Future Fellow, Director – −− Professor Olivier Piguet, NHMRC −− Keith Johnson, PhD Student Software Engineering Group Senior Research Fellow & −− Yasmina Serinel, PhD Student −− Associate Professor Fabio Professor of Neuropsychology −− Stefan Bogdanov, MSc/ Ramos, Machine Learning −− Associate Professor Craig DCP student and Robotics, School of Phillips, NHMRC Dementia Fellow −− Teleri Moore, MCP Computer Science, Co- Director for the Centre for −− Professor Nick Glozier, Professor −− Elie Matar, PhD Student of Psychological Medicine Translational Data Science −− Aaron Schockman, MPhil Student −− Associate Professor Nat Marshall, −− Associate Professor Zhiyong −− Aaron Lam, PhD Student Associate Professor Clinical Wang, School of Computer Trials and Epidemiology −− Dexiao Kong, PhD Student Science, Associate Director – Multimedia Laboratory −− Dr Chris Gordon, Senior −− Melissa Aji, PD Student Lecturer, Nursing −− Rick Wassing , PhD Student −− Dr Svetlana Postnova, School of Physics, Brain −− Dr Shantel Duffy, NHMRC Dynamics Group – Complex Dementia Fellow Professional Staff Systems Research Group −− Dr Maria Comas, Postdoctoral −− Claire Burrows, Clinic −− Dr Somwrita Sarkar, School of Fellow, Woolcock Institue Coordinator & Project Manager Architecture, Design & Planning, of Medical Research −− Stacey West, Study Coordinator, Computational Data Mining −− Dr Angela D’Rozario, NHMRC- Healthy Brain Ageing Program

ARC Dementia Research −− Dr Haley LaMonica , Clinical Our teams Development Research Neuropsychologist Fellow, Woolcock Institute of Medical Research Clinicians −− Dr Camilla Hoyos, NHMRC-ARC −− Dr Jerome Ip, Neurologist, Dementia Research Development Healthy Brain Ageing Clinic Research Fellow, Woolcock −− Dr Dev Banerjee, Sleep Institute of Medical Research Physician, Medical Director −− Dr Loren Mowszowski, NHMRC- – Woolcock Institute ARC Dementia Research −− Dr Catriona Ireland, Geritrician, Development Research Fellow, Woolcock Institute Clinical Neuropsychologist −− Dr Chris Blackwell, Psychiatrist, −− Dr Julia Chapman, Postdoctoral Woolcock Institute Fellow, Woolcock Institute

of Medical Research Page 99 Computational Neuroscience Academic Staff −− Emeritus Professor John −− Professor Alistair −− Associate Professor Michael Pollard, Clinical Neurology McEwan, Electrical and Barnett, Clinical Neurology and Neuroimaging, Core Information Engineering research and leadership team

sydney.edu.au/brain-mind and Neuroimaging, Core −− Associate Professor research and leadership team −− Professor Fernando Armin Nikpour, Neurology −− Associate Professor Weidong Calamante, Clinical Neurology and Neuroimaging (Tom) Cai, Multimodal Image and Neuroimaging −− Dr Richard Morris, Analysis and Computational −− Professor Matthew Translational Data Scientist Analysis, Core research Kiernan, Clinical Neurology and leadership team and Neuroimaging Students −− Professor Dacheng Tao, −− Dr Susanna Park, NHMRC −− Dr Heidi Beadnall, Clinical Imaging Data Integration CJ Martin Fellow & Neurology and Neuroimaging and Machine Learning, Core Neurophysiologist −− Dr Joshua Barton, Clinical research and leadership team −− Dr Sidong Liu, IT, Imaging Neurology and Neuroimaging −− Associate Professor Alexander and Biomedicine −− Chenyu (Tim) Wang, Klistorner, Visual Sciences, Core −− Dr Lindy Ly, Neuropathology, Neuroimaging research and leadership team Neuroimaging Analysis −− Scott Lill, Bioinformatics −− Associate Professor Tom −− Associate Professor Fabio −− Suman Regmi, Bioinformatics Carlson, fMRI, Computational Ramos, Statistical machine −− Antonio Lopes, Bioinformatics Neuroscience, Core research learning techniques and leadership team −− Mayisha Khan, Bioinformatics −− Professor Gregg Suaning, Biomedical Engineering Brain and Mind Centre Annual Report 2017-18 Professional Staff −− Tina Liu, Research Assistant The University of Sydney Page 100 The Lambert Initiative Academic Director −− Dr Elizabeth Cairns, Postdoctoral Professional Staff −− Professor Iain McGregor Research Associate −− Mr Rhys Cohen, Senior −− Mr Lewis Martin, Project Officer Associate Directors Research Associate −− Ms Cheryl Handford, −− Associate Professor Jonathon −− Ms Danielle McCartney, Laboratory Manager Arnold - Preclinical Research Research Associate −− Mrs Paulina Wade, −− Dr Michael Bowen - −− Mr Ivan Low, Research Assistant Administrative Officer Scientific Operations −− Ms Bianca Wilson, Research Assistant Students Research Staff −− Ms Rebecca Vogel, −− Mr Thomas Arkell, PhD candidate −− Dr Samuel Banister, Senior Research Assistant −− Ms Anastasia Suraev, Brain and Mind Centre Research Fellow, Team Leader −− Mr Nick Everett, PhD candidate Medicinal Chemistry Research Assistant −− Mr Joel Raymond, PhD candidate −− Dr Nathan Absalom, −− Ms Ramya Kumar, −− Ms Kristie Leigh Smith, Research Fellow Research Assistant PhD candidate −− Dr Lyndsey Anderson, −− Ms Caitlin Seager, −− Ms Cilla Zhou, PhD candidate Research Fellow Research Assistant −− Ms Yelena Mazur, −− Dr Anand Gururajan, −− Ms Charlotte Fletcher, Master’s student Research Fellow Research Assistant −− Mr Oliver Tan, Master’s student −− Dr Melissa Benson, −− Ms Sarah Abelev, Research Fellow −− Ms Lucy Gold, Master’s student Research Assistant −− Dr Miguel Bedoya Perez, −− Mr Tally Golembiewski, −− Ms Dilara Bahceci, Research Associate Honours student Research Assistant −− Dr Marika Heblinski, −− Ms Jessica Chandra, −− Ms Rhianne Scicluna, Research Associate Honours student Research Assistant −− Dr Richard Kevin, −− Mr Peter Doohan, −− Mr Declan Everett-Morgan, Research Associate Honours student Research Assistant −− Dr Jia Lin Luo, Research Associate Our teams Page 101 Psychology Clinic and Clinical Psychology Unit Academic staff Students −− Vera Yeo, MCP −− Professor Caroline Hunt, Head, −− Lily Baccon, MCP −− Melissa Blair, MCP Clinical Psychology Unit −− Emily Bemmer, MCP −− Lucinda Mairs, MCP sydney.edu.au/brain-mind −− Associate Professor Maree −− Ashley Bogle, MCP −− Alicia Moss , MCP Abbott, Head, Clinical Training −− Kelly Brown, MCP −− Elpiniki Andrew, MCP/PhD −− Professor Sunica Lah, Director −− Ruby Brown, MCP −− Sarah Barakat, MCP/PhD of Clinical Research −− Miranda Cashin, MCP/PhD −− Virginia Burgdorf, MCP/PhD −− Associate Professor Paul Rhodes, Lecturer, Clinical Psychology Unit −− Jonny Ka Chun Chan, MCP −− Danielle Gessler, MCP/PhD −− Associate Professor David −− Lauren Irwin, MCP −− Cecilia Law, MCP/PhD Hawes, Lecturer, Child −− Yu Teng Lee, MCP −− Stephanie Tesson, MCP/PhD Behaviour and Research Clinic −− Shriya Mathur, MCP −− Rachel Brownlow, MCP/PhD −− Professor Stephen Touyz, −− Lindsay McFarlane, MCP −− Nahian Chowdhury, MCP/PhD Clinical Professor −− Markus Michalowski, MCP −− Carri Fisher, MCP/PhD

Professional Staff −− Allyson Ray, MCP −− Lauren Harvey, MCP/PhD −− Shylaja Gooley, Clinical −− Emily Shaw, MCP −− Emma Jones, MCP/PhD Psychologist, Director −− Bonnie Yee Yan Shek, MCP −− Brittany Killer, MCP/PhD Psychology Clinic −− Nadia Shnier, MCP −− Bridie Leonard, MCP/PhD −− Dr David Horry, Psychology Clinic −− Pete Pirathat Techakesari, MCP −− Claire Mcaulay , MCP/PhD −− Chantal Braganza, Clinical −− Emily Wilson, MCP/PhD −− Rachel Menzies, MCP/PhD

Brain and Mind Centre Annual Report 2017-18 Psychologist, Supervisor, −− Dean Wright, MCP −− Belinda Poole (Kirley), MCP/PhD Psychology Clinic −− Jessica Beilharz, MCP −− Amelia Scott, MCP/PhD −− Frances Gibson, PhD Psychologist, Supervisor, −− Catherine Broomfield, MCP/PhD −− Zac Seidler, MCP/PhD Psychology Clinic −− Roanna Chan, MCP −− Amy-Lee Sesel, MCP/PhD −− Belinda Ingram, Education −− Kate Cullen, MCP −− Shannon Webb, MCP/PhD Support Officer, Clinical −− Hayley Donohue, MCP/PhD −− Julia White, MCP/PhD Psychology Unit −− Celina Estacio, MCP −− Alison Young, MCP/PhD −− Elaine Parica, Clinical −− Estelle Goarin, MCP −− Michael Zhang, MCP/PhD Receptionist, Psychology Clinic −− Joshua Hall, MCP −− Matteo Zuccala, MCP/PhD −− Amber Hamilton, MCP −− Grace Morris, MCP −− Samara Noble, MCP −− Aimee Oliveri, MCP −− Karishma Rajan Menon, MCP The University of Sydney −− Laura Rizzuto, MCP −− Samantha Schubert, MCP −− Jit Hui Tan, MCP −− Janice Tang, MCP/PhD Page 102 Gambling Treatment and Research Clinic Academic staff Professional Staff Associates and Collaborators −− Professor Alex Blaszczynski, −− Brittany Keen, Research assistant −− Dr Brett Abarbanel, University Professorial Research Fellow −− Dylan Pickering, of Nevada Las Vegas (USyd & Co-director, GTRC Research assistant Research Affiliate) −− Associate Professor Sally −− Michelle Beckett, −− Dr Kahlil Philander, Gainsbury, Co-director, GTRC Research assistant Washington State University (USyd Research Affiliate) −− Thomas Swanton, Students Research assistant −− Professor Thorsten Teichert, −− Lindsey Procter, University of Hamburg −− Douglas Angus, Research officer Honours Student 2018 (USyd Research Affiliate)

−− Dylan Pickering, PhD Clinicians −− Professor Howard Shaffer, Brain and Mind Centre Student (2016-2019) Harvard University −− Dr Fadi Anjoul, Deputy Director −− Brittany Keen, PhD −− Professor Paul Delfabbro, −− Christopher Hunt, student (2016-2019) University of Adelaide Clinical Psychologist −− Holly Cameron, −− Dr Daniel King, University −− Kerrie Macalister, Honours Student 2017 of Adelaide Registered Psychologist −− Mariefe (Fe) Donaghue, −− Professor Matthew Rockloff, −− Ashley Adolphe , Provisional Honours Student 2017 Central Queensland University Psychologist −− Roisin Lynch, Clinical −− Dr Matthew Browne, Central −− Sophia Tran, Clinical Psychologist Masters Student 2018 Queensland University −− Joshua Battin, −− Jaymee-lee Chebli, PhD/ −− Dr David Forsström, Provisional Psychologist Clinical Masters Student 2018 Stockholm University −− Kirsten Shannon, −− Gavin Entwistle, Clinical −− Professor Robert Ladouceur, Clinical Manager Masters Student 2017 Laval University −− Nicole Allwood, Counsellor −− Kate Beresford, −− Professor Lia Nower, Honours Student 2017 −− Michael Zhang, Rutgers University Registered Psychologist −− Seamus Dillon, Honours Student 2017 −− Janine Bleakley, Registered Psychologist −− Lilian Ma, Honours Student 2018 −− Sarah Rees, Counsellor

−− Jennifer Molinari, Counsellor Our teams

Technical Facilities Laboratory Animal Services −− Melissa Jeanerette, Research Laboratory −− Janelle Wright, Animal Assistant Animal Technician Support Team Facilities officer −− Corey Tutt, Assistant −− Holly Johnson, −− Vince Zappala, Animal Technician Animal Technician Laboratory manager −− Mark Elgario, Assistant −− Robert Agostino, −− Emma Kuebler, Technical Officer Animal Technician Assistant Animal Technician −− Nasyaruddin Mohomad, −− Daniel Dyke Thomas, Technical Officer Assistant Animal Technician −− Ian Garthwaite, Laboratory

Services manager Page 103 Sydney Imaging Academic Staff −− Dr Nana Sunn, Preclinical Facility Manager −− Professor Fernando Calamante, Director −− Dr Sofie Trajanovska, Preclinical of Sydney Imaging Core Research Facility Senior Technical Officer

sydney.edu.au/brain-mind −− Dr Binh Pham, Preclinical Technical Officer Professional Staff −− Mr Anup Bidesi, Clinical −− Ms Elizabeth Blanchard, Senior Technical Officer Operations Manager −− Mr Fan Zhang, Preclinical Technical Officer −− Ms Elizabeth Adrianti, Administration Assistant, −− Ms Zoe Williams, Hybrid Theatre Technical Officer

Microscopy

−− Dr Michael Kuligowski, Senior −− Dr Neftali Flores Rodriguez, Technical Officer Light Optical Microscopist −− Dr Pamela Young, Professional Officer, −− Dr Yingying Su, Senior Light Microscopist Light and Optical Microscopist −− Ms Ellie Kable, Facility Manager

Brain and Mind Centre Annual Report 2017-18 Neuropathology Academic Staff −− Professor Deon Venter, −− Associate Professor Roger Postgraduate fellow Neuropathology Pamphlett, Clinical Academic −− Dr Joanne Sy, −− Dr Kim Kaufman, Brain tumour bank Staff specialist Neuropathology manager, Brain tumour researcher −− Dr Andrew Colebatch, Advanced pathology trainee Students −− Dr Karina Avazian, −− Saiedeh Ebrahimkhani, PhD student Advanced pathology trainee −− Susannah Hallal, PhD student Associates and Collaborators −− Ali Azimi, PhD student −− Maggie Lee, Senior Hospital Professional Staff Scientist, Neuropathology −− Stephen Kum Jew, Senior Technical Officer −− Dr Grace (Heng) Wei, Hospital Scientist,

The University of Sydney Molecular neuropathology laboratory Clinicians −− Dr Antony Harding, Senior −− Clinical Associate Professor Michael scientist, tissue banking Buckland, Head, RPA Department −− Karina Hammond, Technical Officer of Neuropathology; Co-Director, −− Diana Van Beek, Technical Officer MS Research Australia Brain Bank; Founder, Australian Sports Brain Bank Page 104 Neurology Lab Academic Staff Professional Staff −− Dr Min-Xia Wang, Principal −− Toan Nguyen, Senior Technical Officer Hospital Scientist −− Dr Rena Ma, Technical Officer −− Dr Fang Liu, Technical Officer

Child Behaviour Clinic

−− Professor Mark Dadds Director −− Ms Nicole Langman, Clinical Placement Student (clinician)

−− Assoc Prof David Hawes,Co-Director Brain and Mind Centre −− Ms Carrie Fisher, PhD student −− Ms Utsa Mathur, Clinical Placement Student (clinician) −− Ms Jaimie Northern, PhD student −− Ms Emma Smadbeck, Clinical −− Ms Janice Tang, PhD student Placement Student (clinician) −− Ms Elpiniki Andrews, PhD student −− Ms Ruth White, Clinical −− Ms Charlotte Burman, Honours student Placement Student (clinician) −− Ms Shriya Mathur, Masters student −− Ms Sophia Palm, Clinical −− Ms Sarah Li, Honours students Placement Student (clinician) −− Ms Kim McGregor, PhD student −− Ms Sarah Altmann, Clinical −− Ms Stavroola Anderson, PhD student Placement Student (clinician) −− Ms Aimee Oliveri, Masters student Ms −− Ms Theresa Donnelly, Clinical Placement Student (clinician) −− Ms Samara Noble, Masters student −− Ms Catherine Gaussen, Clinical −− Ms Lindsay McFarlane, Masters student Placement Student (clinician) −− Ms Yu Teng Lee, Masters student −− Ms Diana Paardekooper, Clinical −− Ms Kelly Brown, Masters student Placement Student (clinician) −− Dr Meryn Lechowicz, Clinic Manager −− Dr Greg Quartly-Scott, Clinical −− Ms Alex Roach, Psychologist Placement Student (clinician) −− Dr Lucy Tully, Project Manager −− Assoc Prof Eva Kimonis, Collaborator

−− Dr Fran Doyle, Project Manager −− Professor Valsa Eapen, Collaborator Our teams −− Ms Metaxia Kokkinos, Clinical −− Professor Paul Frick, Collaborator Placement Student (clinician) −− Dr Divya Mehta, Collaborator −− Ms Emily Sharpe, Clinical −− Dr Caroline Moul, Collaborator Placement Student (clinician) −− Professor Adam Guastella, Collaborator −− Ms Lisa Hansen, Clinical Placement Student (clinician) Page 105 The University of Sydney sydney.edu.au Brain 2017-18 Mind Annual Centre and Report The University of Sydney sydney.edu.au/brain-mind

Additional contact details sydney.edu.au/brain-mind +61 2 9351 0774  /brainandmindcentre

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Produced by The Brain and Mind Centre, the University of Sydney, July 2019. The University reserves the right to make alterations to any information contained within this publication without notice.