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Brain and Mind Centre Annual Report 2017-18 Contact us sydney.edu.au/brain-mind +61 2 9351 0774 Forest Stewardship Council (FSC®) is a globally recognised certification Forest Stewardship Council (FSC®) is a globally recognised certification overseeing all fibre sourcing standards. This provides guarantees for the consumer that products are made of woodchips from well-managed forests and other controlled sources with strict environmental, economical and social standards. Contents Overview ��������������������������������������������������������� 2 Sydney Neuroimmunology ��������������������������� 49 Key research themes �������������������������������������������� 2 Our core business ...............................................50 - Research areas .....................................................51 Welcome ���������������������������������������������������������4 Highlights ............................................................... 52 Co-Directors’ message ���������������������������������������� 4 Publications ..........................................................53 Message from the University ............................... 6 - Message from Teresa Anderson ......................... 7 Sleep and Circadian Biology ������������������������ 57 - Our core business ...............................................58 Child Neurodevelopment Current research .................................................59 and Mental Health ������������������������������������������ 8 Highlights ...............................................................60 Our core business ................................................. 9 2019 and beyond ...................................................61 A preventative, holistic Key publications ................................................... 62 and supportive approach - to child mental health ........................................ 10 Computational Neuroscience ���������������������64 Our team .................................................................11 Our core business ...............................................65 Highlights ................................................................12 Highlights ...............................................................66 - Key publications ...................................................68 Youth Mental Health ��������������������������������������14 - Our core business ................................................15 Technical Facilities ��������������������������������������� 70 Key projects and clinical trials ...........................16 Highlights ............................................................... 73 Highlights ................................................................18 Key publications ................................................... 74 Key publications ...................................................20 Neuropathology ................................................... 75 - Highlights ............................................................... 76 Psychology Clinic ����������������������������������������� 23 Key publications ................................................... 77 Our core business ............................................... 24 Microscopy ........................................................... 78 Highlights ............................................................... 25 Neurology Laboratory ���������������������������������������� 79 Key publications ................................................... 26 Key publications ...................................................80 - - Child Behaviour Lambert Initiative ������������������������������������������81 Research Clinic �������������������������������������������� 27 Our core business ............................................... 82 Our core business ............................................... 28 Highlights ...............................................................83 Grants / funding ..................................................29 Grants awarded ................................................... 87 Key publications ...................................................30 Key publications ................................................... 87 - - Gambling Treatment Brain and Mind Centre ��������������������������������� 88 and Research Clinic ������������������������������������� 32 Our donors............................................................88 Our core business ...............................................33 Supporting research ...........................................89 Research ...............................................................34 Supporting early-career Clinical practice ...................................................35 researchers...........................................................90 Cultural outreach and education .....................36 Thanks to our donors ..........................................91 Industry engagement .......................................... 37 Our teams .............................................................92 Highlights ...............................................................38 Key publications ...................................................39 - ForeFront Ageing and Neurodegeneration �������������������������������40 Our core business ................................................41 ForeFront research teams .................................42 Highlights ...............................................................44 Key publications ...................................................46 Page 1 Overview Key research themes At the University of Sydney’s Brain and Mind Centre, our sydney.edu.au/brain-mind teams partner across borders and disciplines in pursuit of a common goal: to develop better treatments for conditions of the brain and mind, and improve health outcomes now and for future generations. Our multidisciplinary research teams are at Our visionary research teams span the forefront of brain and mind sciences. We preclinical, clinical and translational work to find answers to some of the world’s research. Our work extends beyond most pressing health concerns, including: laboratories and clinics to our strong − childhood development partnerships with industry, government, the and behaviour disorders community, other healthcare providers and diverse branches of academia to make a real − youth mental health and addiction difference to people’s lives. − ageing and neurodegeneration. Brain and Mind Centre Annual Report 2017-18 The University of Sydney Associate Professor Muireann Irish Page 2 and PhD candidate Siddharth Ramanan Page 3 Key research themes Overview Welcome Co-Directors’ message Welcome to the Brain and Mind Centre Annual Report, which celebrates our many achievements over the past two years. sydney.edu.au/brain-mind 2017–18 has been a period of growth The partnership will benefit people and exploration of new potential with a range of neurological for the Brain and Mind Centre. illnesses, including multiple Our collaborations, both across sclerosis and dementia. University of Sydney campuses, and with external partners such as Our transformative work would not Local Health Districts, government, be possible without philanthropy. In industry and community bodies, a climate where it has never been have led to the establishment more difficult to secure competitive of exciting new multidisciplinary grant funding, philanthropy has Professor Matthew Kiernan AM Co-Director, Discovery research teams. The unique allowed our innovative research and Translation perspective of these teams means to continue to thrive. In particular, we can combine cutting-edge private donations have supported research with safe and effective the appointment of a number of clinical approaches, this enables us leading researchers within the Brain to pioneer new systems of care for and Mind Centre. Following a $1.5 those affected by disorders of the million commitment from a private Brain and Mind Centre Annual Report 2017-18 brain and mind. family, the Brain and Mind Centre has been able to establish a new The last two years have seen Chair in translational research. a focus on further developing 2018 saw the appointment of our strategic partnerships with Professor Cindy (Shin-Yi) Lin to Professor Ian Hickie AM this position, the Kam Ling Barbara Co-Director, Health and Policy industry. By working closely with a range of industry partners, the Lo Chair in Neurodegenerative Brain and Mind Centre has been Disorders. Professor Lin’s able to translate new technologies academic leadership will enable and research discoveries into the Centre to leverage its efforts innovations that benefit society and to develop novel diagnostic the economy. One such success biomarkers and lead clinical trials has come from our Computational of new therapies for a range of Neuroscience team. Itself a neurodegenerative disorders. unique collaboration between the Faculty of Medicine and Health Philanthropy has also been vital in and the Faculty of Engineering and the support of a future generation The University of Sydney Rod Gilroy, Information Technology, the team of leaders in the brain and mind Chief Operating Officer Brain and Mind Centre has partnered with the Sydney sciences by funding early-career Neuroimaging Analysis Centre and research fellowships. Thanks to a I-MED Radiology Network on a very generous donation from the $2.36 million Cooperative Research Bluesand Foundation, Dr Eleanor Centre-Project to develop and Drummond has been
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