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BMJ Open Is Committed to Open Peer Review. As Part of This Commitment We Make the Peer Review History of Every Article We Publish Publicly Available BMJ Open: first published as 10.1136/bmjopen-2018-026362 on 17 July 2019. Downloaded from BMJ Open is committed to open peer review. As part of this commitment we make the peer review history of every article we publish publicly available. When an article is published we post the peer reviewers’ comments and the authors’ responses online. We also post the versions of the paper that were used during peer review. These are the versions that the peer review comments apply to. The versions of the paper that follow are the versions that were submitted during the peer review process. They are not the versions of record or the final published versions. They should not be cited or distributed as the published version of this manuscript. BMJ Open is an open access journal and the full, final, typeset and author-corrected version of record of the manuscript is available on our site with no access controls, subscription charges or pay-per-view fees (http://bmjopen.bmj.com). If you have any questions on BMJ Open’s open peer review process please email [email protected] http://bmjopen.bmj.com/ on September 25, 2021 by guest. Protected copyright. BMJ Open BMJ Open: first published as 10.1136/bmjopen-2018-026362 on 17 July 2019. Downloaded from Protocol of the China STEMI Care Project: a 10-year project to improve quality of care by building up the regional STEMI care network ForJournal: peerBMJ Open review only Manuscript ID bmjopen-2018-026362 Article Type: Protocol Date Submitted by the 29-Aug-2018 Author: Complete List of Authors: Zhang, Yan; Peking University First Hospital, Department of Cardiology Yu, Bo; Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, 2nd Affiliated Hospital of Harbin Medical University, Cardiology Han, YL; The General Hospital of Shenyang Military, department of cardiology Wang, Jianan; The Second Affiliated Hospital, Zhejiang University, Department of Cardiology Yang, Lixia; Kunming General Hospital of Chengdu Military Command of PLA, department of cardiology Wan, Zheng; The General Hospital of Tianjin Medical University, department of cardiology http://bmjopen.bmj.com/ Zhang, Zheng; The First Hospital of Lanzhou University, department of cardiology Chen, Yu-guo; Shandong University, Department of Emergency Fu, Xianghua; Shanxi Cardiovascular Hospital, department of cardiology Gao, Chuanyu; Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Cardiology Li, Bao; Shanxi Cardiovascular Hospital, department of cardiology Chen, Ji-yan; Guangdong Cardiovascular Institute, Guangdong provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong on September 25, 2021 by guest. Protected copyright. General Hospital, Guangdong Academy of Medical Sciences, Cardiology Wu, Ming; Hainan General Hospital, Department of cardiology Ma, Yitong; The First Affiliated Hospital of Xinjiang Medical University, department of cardiology Zhao, Xingsheng; Inner Mongolia People’s Hospital, department of cardiology Chen, Yundai; Chinese PLA General Hospital, department of cardiology Yan, Hongbing; Fuwai Hospital, Chinese Academy of Medical Sciences, department of cardiology Xiang, Dingcheng; General Hospital of Guangzhou Military Command of PLA, department of cardiology Fang, Weiyi; Shanghai Chest Hospital, department of cardiology Mehta, Sameer; Lumen Foundation Naber, Christoph K; Stent Save a Life Ge, Junbo; Zhongshan Hospital Fudan University, department of cardiology Huo, Yong ; Peking University First Hospital, For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 1 of 44 BMJ Open BMJ Open: first published as 10.1136/bmjopen-2018-026362 on 17 July 2019. Downloaded from 1 2 3 Accreditation, chest pain center, network, reperfusion, ST-elevation 4 Keywords: myocardial infarction 5 6 7 8 9 10 11 12 13 14 15 16 For peer review only 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 http://bmjopen.bmj.com/ 33 34 35 36 37 38 39 40 on September 25, 2021 by guest. Protected copyright. 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 2 of 44 BMJ Open: first published as 10.1136/bmjopen-2018-026362 on 17 July 2019. Downloaded from 1 2 3 4 Protocol of the China STEMI Care Project: a 10-year project to improve quality 5 6 of care by building up the regional STEMI care network 7 8 9 10 1 2 3 4 5 6 11 Yan Zhang , Bo Yu , Yaling Han , Jianan Wang , Lixia Yang , Zheng Wan , Zheng 12 13 Zhang7, Yuguo Chen8, Xianghua Fu9, Chuanyu Gao10, Bao Li11, Jiyan Chen12, Ming 14 15 13 14 15 16 17 16 Wu , YitongFor Ma , Xingsheng peer Zhao review, Yundai Chen , onlyHongbing Yan , Dingcheng 17 18 Xiang18, Weiyi Fang19, Sameer Mehta20, Christoph K. Naber21, Junbo Ge22, *Yong 19 20 1 21 Huo , on behalf of China STEMI Care Project (CSCAP) Investigators 22 23 24 25 26 1. Department of Cardiology, Peking University First Hospital, Beijing, China 27 28 2. Department of Cardiology, The Second Affiliated Hospital of Harbin Medical 29 30 University, Harbin, Heilongjiang Province, China 31 32 http://bmjopen.bmj.com/ 33 3. Department of Cardiology, The General Hospital of Shenyang Military, 34 35 Shenyang, Liaoning Province, China 36 37 38 4. Department of Cardiology, The Second Affiliated Hospital Zhejiang University 39 40 School of Medicine, Hangzhou, Zhejiang Province, China on September 25, 2021 by guest. Protected copyright. 41 42 43 5. Department of Cardiology, Kunming General Hospital of Chengdu Military 44 45 Command of PLA, Kunming, Yunnan Department of Cardiology, 46 47 48 6. Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, 49 50 China 51 52 7. Department of Cardiology, The First Hospital of Lanzhou University, Lanzhou, 53 54 55 Gansu Province, China 56 57 1 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 3 of 44 BMJ Open BMJ Open: first published as 10.1136/bmjopen-2018-026362 on 17 July 2019. Downloaded from 1 2 3 4 8. Department of Emergency, Qilu Hospital of Shandong University, Jinan, 5 6 Shandong Province, China 7 8 9. Department of Cardiology, The Second Hospital of Hebei Medical University, 9 10 11 Shijiazhuang, Hebei Province, China 12 13 10. Department of Cardiology, Henan Provincial People’s Hospital, Zhengzhou, 14 15 16 Henan Province,For China peer review only 17 18 11. Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi 19 20 21 Province, China 22 23 12. Department of Cardiology, Guangdong General Hospital, Guangzhou, 24 25 26 Guangdong Province, China 27 28 13. Department of Cardiology, Hainan General Hospital, Haikou, Hainan Province, 29 30 China 31 32 http://bmjopen.bmj.com/ 33 14. Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical 34 35 University, Urumchi, The Xinjiang Uygur Autonomous Region, China 36 37 38 15. Department of Cardiology, Inner Mongolia People’s Hospital, Hohhot, The Inner 39 40 Mongolia Autonomous Region, China on September 25, 2021 by guest. Protected copyright. 41 42 43 16. Department of Cardiology, Chinese PLA General Hospital, Beijing, China 44 45 17. Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical 46 47 48 Sciences, Beijing, China 49 50 18. Department of Cardiology, General Hospital of Guangzhou Military Command of 51 52 PLA, Guangzhou, Guangdong Province, China 53 54 55 19. Department of Cardiology, Shanghai Chest Hospital, Shanghai, China 56 57 2 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 4 of 44 BMJ Open: first published as 10.1136/bmjopen-2018-026362 on 17 July 2019. Downloaded from 1 2 3 4 20. Lumen Foundation, Miami, USA 5 6 21. Stent Save a Life, Paris, France 7 8 22. Department of Cardiology, Zhongshan Hospital Fudan University, Shanghai, 9 10 11 China 12 13 14 15 16 Running title:For Protocol peer of 10-year Chinareview STEMI Care Projectonly 17 18 19 20 21 Corresponding author: Yong Huo, MD 22 23 Peking University First Hospital, Department of Cardiology 24 25 26 8 Xishiku St, Xicheng District, Beijing, China, 100035 27 28 Email: [email protected] 29 30 Phone: 86-10-83572283 31 32 http://bmjopen.bmj.com/ 33 Fax: 86-10-66137748 34 35 36 37 38 Date: 39 40 This project was initialed in 2011 and will be finished in 2021. on September 25, 2021 by guest. Protected copyright. 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 3 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 5 of 44 BMJ Open BMJ Open: first published as 10.1136/bmjopen-2018-026362 on 17 July 2019. Downloaded from 1 2 3 4 Abstract 5 6 Introduction: The China STEMI (ST-elevation myocardial infarction) Care Project 7 8 (CSCAP) aimed to improve the reperfusion treatment rate and shorten the total 9 10 11 duration of myocardial ischemia by establishing a regional STEMI treatment network 12 13 covering the whole city region, whole city population, and whole disease processes 14 15 16 step by step.For peer review only 17 18 Methods and analysis: This is a prospective, multicenter registry involving three 19 20 21 stages. And the CSCAP included 18 provinces, 4 municipalities, and 2 autonomous 22 23 regions in China. Patients with STEMI who met with the third acute myocardial 24 25 26 infarction definition of 2012 and the Chinese STEMI diagnosis and treatment 27 28 guidelines were enrolled. Phase 1 focused on the in-hospital process optimization of 29 30 primary percutaneous coronary intervention (PPCI) hospitals; phase 2 on the PPCI 31 32 http://bmjopen.bmj.com/ 33 hospital-based regional STEMI transfer network, including emergency medical 34 35 services and non-PPCI hospitals; and phase 3 on the whole-city STEMI care network 36 37 38 construction by promoting chest pain center accreditation.
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