ANALYSIS of ALTERNATIVES and SOCIO-ECONOMIC ANALYSIS

ANALYSIS OF ALTERNATIVES and SOCIO-ECONOMIC ANALYSIS

PUBLIC VERSION

Legal name of applicant(s): BASF SE

Submitted by: BASF SE

Substance: 1,2-dichloroethane (EDC) (EC Number: 203-458-1, CAS Number: 107-06-2)

Use title: Industrial use as a recyclable solvent and extraction agent in a closed system for purification of 1,3,5-trioxane

Use number: 1 ANALYSIS OF ALTERNATIVES and SOCIO-ECONOMIC ANALYSIS

CONTENTS

DECLARATION ...... 5 1. SUMMARY ...... 6 2. AIMS AND SCOPE OF THE ANALYSIS ...... 8 2.1 Aim of the AoA and SEA ...... 8 2.2 Substitution strategy ...... 8 2.3 Boundaries of the AoA and SEA ...... 8 2.4 Relevant supply chains ...... 8 3. APPLIED FOR “USE” SCENARIO ...... 9 3.1 Analysis of substance function ...... 9 3.1.1 Details of the function performed ...... 9 3.1.2 Process conditions ...... 10 3.1.3 Functional requirements ...... 10 3.2 Market and business trends including the use of the substance ...... 11 3.2.1 Annual tonnage of EDC ...... 11 3.2.2 Market trends for trioxane and POM ...... 11 3.3 Remaining risk of the “applied for use” scenario ...... 12 3.3.1 Overview ...... 12 3.3.2 Risks to workers of the applied for use ...... 13 3.3.3 Risks for humans exposed via the environment ...... 14 3.4 Human health and environmental impacts of the applied for use scenario ...... 14 3.5 Monetised damage of human health and environmental impacts ...... 15 4. SELECTION OF THE “NON-USE” SCENARIO ...... 17 4.1 Efforts made to identify alternatives ...... 17 4.1.1 Research and development ...... 17 4.1.2 Data searches ...... 18 4.2 Identification of known alternatives ...... 19 4.3 Assessment of shortlisted alternatives ...... 20 4.3.1 Alternative 1 – Benzene ...... 20 4.3.2 Alternative 2 – Dichloromethane (DCM) ...... 21 4.3.3 Alternative 3 – N-butyl methyl ether ...... 23 4.3.4 Alternative 4 – Isoflurane ...... 25 4.3.5 Alternative 5 – Crystallisation (alternative technology) ...... 26 4.3.6 Alternative 6 – Pressure swing distillation (alternative technology) ...... 28 4.4 The most likely non-use scenario ...... 30 4.4.1 Summary of conclusions on alternatives ...... 30 4.4.2 Implications of switching to an alternative ...... 31 4.4.4 Overall conclusions on the non-use scenario ...... 33 5. IMPACTS OF GRANTING AUTHORISATION ...... 34 5.1 Economic impacts ...... 34 5.1.1 Scope of the analysis ...... 34 5.1.2 Supply/value chain and markets affected ...... 34 5.1.3 Direct economic impacts for BASF ...... 35 5.1.4 Economic impacts for downstream users (POM processors)...... 36 5.1.5 Economic impacts for end-users ...... 37 5.1.6 Significance of impacts and uncertainties ...... 39 5.2 Human health and environmental impacts ...... 40 5.3 Social impacts ...... 40 5.4 Wider economic impacts ...... 41 5.5 Distributional impacts ...... 41

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5.6 Uncertainty analysis ...... 41 6. CONCLUSIONS ...... 43 6.1 Comparison of the benefits and risk ...... 43 6.2 Information for the length of the review period ...... 45 6.3 Substitution effort taken by the applicant if an authorisation is granted ...... 47 7. REFERENCES ...... 48 Annex – Justifications for Confidentiality Claims ...... 49 APPENDCES ...... 50 Appendix 1: ...... 51 Appendix 2: ...... 52 Appendix 3: ...... 53

TABLES

List of tables Table 1 Sales volume, value and profitability of Ultraform® plant ...... 12 Table 2 ECHA estimates of benefits of avoiding cancer ...... 15 Table 3 Initial screening/exclusion criteria for possible alternative solvents ...... 17 Table 4 Key properties for benzene ...... 20 Table 5 Key properties for dichloromethane ...... 22 Table 6 Key properties for N-butyl methyl ether ...... 23 Table 7 Key properties for Isoflurane ...... 25 Table 8 Summary of conclusions on alternatives ...... 30 Table 9 Main steps to implement an alternative production process ...... 31 Table 10 Main steps to implement a (hypothetical) alternative solvent ...... 32 Table 11 Global supply and demand for POM (IHS Chemical, 2014) ...... 38 Table 12 Key applications of POM in transportation applications ...... 39 Table 13 Monetary value estimates of human health impacts ...... 40 Table 14 Summary of avoided excess cancer risk and monetary valuation ...... 44 Table 15 Summary of quantified benefits and costs (annualised values) ...... 45 Table 16 Demonstration that BASF Ultraform® case fulfils case for long review period ...... 46

List of figures Figure 1 Simplified schematic illustrating use of EDC in trioxane purification ...... 9 Figure 2 BASF’s trioxane and POM production plant ...... 10 Figure 3 EBIT for BASF Ultraform Business in Europe and RoW zone ...... 12 Figure 4 Schematic flow diagram for trioxane production via pressure swing distillation ...... 28 Figure 5 Simple representation of trioxane and POM supply/value chain ...... 35 Figure 6 BASF production and global markets for POM ...... 36 Figure 7 Comparison of BASF Ultraform® plant risks with German risk-based concept for carcinogenic substances ...... 43

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LIST OF ABBREVIATIONS

DCM = Dichloromethane

EBITDA = Earnings before interest, tax, depreciation and amortisation

EDC: Ethylene dichloride

FA = Formaldehyde

POM: Polymer polyoxymethylene (trade name Ultraform®)

Trx = Trioxane (1,3,5-trioxane)

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DECLARATION

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1. SUMMARY

This is the combined analysis of alternatives and socio-economic analysis (AoA/SEA) document which forms part of BASF’s application for authorisation for use of EDC in trioxane purification.

The document demonstrates that the benefits of continued use of EDC in purification of trioxane clearly outweigh the risks of continued use and that there are no suitable, available alternatives.

BASF uses EDC in production of trioxane, which is then used as a monomer in the production of the polymer polyoxymethylene (POM), also known as polyacetal. The trade name of the polymer is Ultraform®. Trioxane is first extracted into EDC from water, and then distilled off to yield the very pure trioxane monomer that is needed for POM production.

The sole location of this use is at BASF’s plant at Ludwigshafen in Germany. BASF’s use of EDC is within an industrial process, with no subsequent use by professionals or consumers. There is negligible EDC present in either the purified trioxane monomer (<1ppm), POM or the end products.

BASF is one of four major producers of POM (polyacetal) in Europe. There are other major producers of POM that have recently increased production in Asia and North America, indicating a highly competitive market for this polymer.

POM is used in a huge range of end products, primarily in the transportation (e.g. fuel systems), industrial (e.g. electrical devices), consumer (e.g. medical products and sporting equipment) and construction (e.g. plumbing) sectors.

Despite extensive research, BASF has not identified an alternative substance or technique that could be implemented within BASF’s existing production plant and that would be technically and commercially acceptable. BASF therefore anticipates continuing to require the use of EDC for the foreseeable future, given the extent and duration of BASF’s research.

Approximately 60 tonnes of EDC needs to be replaced annually, resulting from losses to the closed off-gas incineration system, as well as loss through reaction with sodium hydroxide which is used as a neutralisation agent in the process. Losses to the environment are very small, with no concern identified for humans exposed via the environment as set out in the CSR.

As set out in the CSR, the remaining cancer risks of the 'applied for use scenario' are very small, and relate solely to workers at the Ultraform® plant. Individual lifetime cancer risk is estimated to be 6 x 10-6, related to inhalation exposure of EDC. Taking into account the number of workers exposed to EDC and their pattern of work, the total excess cancer risk for the plant as a whole is estimated to be 3.9 x 10-5, which has been valued at around €200 per year, based on the estimate for the value of a statistical life, taking into account the values set out in a recent study for ECHA.

BASF has analysed over 7000 potential alternative solvents for use in the Ultraform® plant as a replacement to EDC. It is demonstrated in the analysis of alternatives that none of these could be used in the existing Ultraform® plant.

There are alternative methods for production of trioxane, notably a “crystallisation” process and a “pressure-swing distillation” process. While these could in theory be used by BASF to produce POM, their use would necessitate construction of a new production plant, making the existing trioxane plant redundant. This would cost around [Claim #2] and would also take several years beyond the sunset date for EDC (estimated 11.5 years for BASF to develop the process, or 8 years if BASF were able to buy a licence from a competitor), meaning that this is not a viable non-use scenario: BASF would lose its market share for POM irrecoverably.

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BASF have reviewed the options for continuation of this line of business. In the event that BASF is not granted an authorisation for continued use, the senior management have concluded that the non-use scenario would be closure of the trioxane production plant, and along with it the POM production plant

The financial impact to BASF of non-authorisation would be:

[Claim #1] revenues per year, equating to a present value of around [Claim #1] based on an ‘impact realisation’ period of 12 years from the sunset date.

Loss of profit (EBITDA) associated with this loss of revenues of around [Claim #1], or around [Claim #1] present value over the same period.

If, in the longer term, BASF decides to continue its production of POM polymer, BASF would also incur costs associated with construction of a new trioxane production plant. This would only enable production of POM several years after the sunset date, during which time the above estimates of revenue and profits foregone would be incurred. This is expected to take several years and the cost is estimated at around [Claim #2] (for use of the crystallisation process). Expressed in annualised terms, this equates to a cost of [Claim #2] per year.

There would also be costs to BASF's customers for POM, in the event that a new process were developed. BASF has made a provisional estimate of the potential cost of this requalification in the automotive industry of [Claim #1]. This is likely to be a one-off cost, borne over the course of approximately a year. The automotive sector is just one of many end-user sectors for POM, and similar requalification costs would be borne by other sectors.

There would be direct implications for BASF in terms of employment, with a net reduction in numbers employed, estimated at [Claim #2] people.

There would be wider economic impacts, including loss of economic activity associated with POM production at Ludwigshafen, expected to be replaced by production from outside the EU; reduced competition in the European POM production market (from the current four main producers to three); and reduced tax and other revenues in Europe.

The overall costs and benefits of a non-granted authorisation have been estimated in quantitative terms. Based on the best estimate of exposure (and associated cancer risks), the benefits are estimated at only €5 (five Euros) per year. The costs to BASF are estimated at over €20 million per year, based on profits foregone, as well as the costs of constructing a new plant using alternative technology in the longer term. The costs of not granting an authorisation are therefore more than 5 million times the benefits.

BASF believes that a long authorisation period (12 years) is warranted. This is a business with long-term investment made in the plant. Despite extensive research, there are no suitable alternatives available to BASF, and this is unlikely to change in the near future. The possible alternative technologies (crystallisation) are prohibitively expensive and are not currently available to BASF; they will therefore not be implemented at Ludwigshafen in the event of non-authorisation. Furthermore, the remaining risks are limited to workers at the Ludwigshafen site, and are very low, so as to be negligible compared to the costs of non-authorisation.

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2. AIMS AND SCOPE OF THE ANALYSIS

2.1 Aim of the AoA and SEA This analysis evaluates the socio-economic benefits of continued use of EDC for the use concerned, compared to the risks to human health of continued use. It concludes that the benefits outweigh the risks and that there are no suitable alternative substances or techniques.

2.2 Substitution strategy BASF produces the polymer polyoxymethylene (POM) (trade name Ultraform®, also referred to as polyacetal) at its site in Ludwigshafen, Germany. This forms part of BASF’s ‘performance materials’ division.

The production is an integrated process involving production of formaldehyde from methanol, followed by conversion of formaldehyde to yield 1,3,5-trioxane (“trioxane”). Trioxane is then purified using EDC as an extraction solvent, giving the purification necessary for the production of high quality POM polymer. Production was originally undertaken by Ultraform GmbH (a joint venture between BASF AG and Degussa AG) since 1969 and BASF has been operating this plant since 1999.

EDC is an essential solvent in BASF’s production process. Due to the classification of EDC as a category 1B carcinogen (and more recently since its inclusion on the Candidate List and Authorisation List), BASF has undertaken significant research into potential alternatives, both alternative extraction solvents for trioxane, and also alternative production processes for trioxane. Since its classification as such, BASF has had a responsibility to consider replacement as the primary means of addressing the risks of the substance under the Carcinogens and Mutagens Directive (2004/37/EC).

To date, despite extensive research, BASF has not identified an alternative substance or technique that could be implemented within BASF’s existing production plant and that would be available whilst also being technically and commercially acceptable. BASF therefore anticipates continuing to require the use of EDC for the foreseeable future, given the extent and duration of BASF’s research.

Details of the research undertaken into substitution are in Section 4.

2.3 Boundaries of the AoA and SEA In terms of geographic boundaries, BASF’s use of EDC is within an industrial process only, with no subsequent use by professionals or consumers. The sole location of use is at BASF’s plant at Ludwigshafen in Germany.

EDC is present in only trace (<1ppm) quantities in the purified trioxane so subsequent use is not relevant for authorisation. However, the POM polymer is used in a wide range of applications which are of substantial benefit to society, and which are used widely throughout the EU and beyond. This is also considered within the AoA and SEA as these products would be affected in the event of non-authorisation.

In the event of non-authorisation, the main economic impacts upon BASF, its customers and wider society would occur from or around the sunset date of 22 November 2017 and would continue over several years. Impacts upon workers’ health, associated with (reduced) exposure to EDC, and the potential alternatives, may occur over long periods of time. Such impacts for EDC are assessed in terms of lifetime excess cancer risk, based on ECHA’s (2015) dose-response relationship information.

2.4 Relevant supply chains The scope of this analysis covers potential alternatives for the production of trioxane and POM polymer. EDC is manufactured by BASF on the same integrated chemical site at Ludwigshafen in Germany. Since EDC presence in the final products is not relevant to authorisation (i.e. the ‘physical flow’ of EDC stops at the trioxane purification stage), alternatives to POM polymer itself and its associated products have not been considered.

However, the EU market for POM production and its socio-economic importance is an important consideration. The value chains considered therefore extend to the sales of POM, both within the EU (where it is used in various countries and industries) and to outside the EU, and the use of POM in a number of key applications, where there could be substantial impacts on the end-consumer. These are therefore economic flows, rather than physical flows.

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3. APPLIED FOR “USE” SCENARIO

3.1 Analysis of substance function

3.1.1 Details of the function performed High-purity trioxane monomer is necessary to ensure an efficient polymerisation reaction and EDC is used to purify trioxane in two parallel plants, both of which are within the Ultraform® facility at Ludwigshafen. EDC is used in a closed system being delivered from a central storage tank via pipe into the plant’s closed extraction / distillation system. EDC is added to trioxane in the aqueous phase (in which trioxane forms an azeotropic mixture), and extracts the trioxane into the organic phase by overcoming the azeotrope. A distillation process is then applied to extract pure (>99%) trioxane, while the EDC is recycled to the extraction phase.

BASF is a highly integrated business along the entire POM value chain, from production of methanol used in formaldehyde production, through production and purification of trioxane to production of POM polymer, the product ultimately sold by BASF.

The figure below provides a simplified schematic of the use of EDC in the purification of trioxane.

Figure 1 Simplified schematic illustrating use of EDC in trioxane purification

This process yields trioxane which is over 99% pure, for supply to the polymerisation unit on site. The resulting POM is sold by BASF as pellets/granules, and is primarily used by customers in injection moulding using specific tools/moulds, with some being used in extrusion for subsequent processing e.g. by computer numerical controlled (CNC) machining. The final POM products are used in a vast range of different applications, such as: medical equipment, gear wheels, toys, loudspeaker grills, fuel tank modules, sanitary equipment, fuel pumps, parts in printers/copiers, components in conveyors for food processing, sockets for ball bearings, zips, safety buckles, car seat belt stop mechanisms, to name a small selection of examples. In terms of industrial sectors, around 35% of POM consumption in Western Europe in 2013 was for automotive applications (IHS Chemical, 2014).

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The figure below shows the BASF production plant in Ludwigshafen. Whilst it is a facility dedicated to production of trioxane and POM, it is integrated with other facilities on the site.

Figure 2 BASF’s trioxane and POM production plant

Photograph: BASF SE

A small proportion of the annual production volume of trioxane – [Claim #1] – is sold as a chemical intermediate (for industrial production of chemicals). As EDC is not present in trioxane (the concentration is below 1 ppm, and hence the EDC in trioxane itself is not subject to authorisation) this minor use is not discussed further here.

3.1.2 Process conditions The extraction of trioxane is done using an extraction tower that is equipped with sieve trays. The process runs under ambient pressure and a temperature that is adjusted to [Claim #4]. At the top of the extraction tower a solution of formaldehyde in water is received, which is recycled to the trioxane reactor. At the bottom a mixture of trioxane and EDC is obtained, which contains traces of formic acid. This acid is neutralised with a sodium hydroxide solution and the resulting sodium formate is washed with demineralised water. For both steps, two additional towers equipped with sieve trays are used. These towers are also operated at [Claim #4] and under ambient pressure. The bottom product of the washing tower is separated in EDC and trioxane using a rectification tower that is run under ambient pressure. The temperature at the bottom of the column is about 130°C and at the top it is around 80°C. The EDC is recycled to the extraction process, while the trioxane is transferred to the POM production line.

3.1.3 Functional requirements The technical/functional requirements of a solvent that are relevant to finding an alternative fulfilling or replacing the equivalent function are as follows:

 The solvent must not form an azeotrope with trioxane, so as to enable effective rectification.  The solvent must be stable in contact with sodium hydroxide (formic acid as a by-product is removed by washing with NaOH solution).  Any trace impurities of the solvent in trioxane must not hamper the polymerisation of POM.  The boiling point of the solvent should be above 70°C to avoid extensive losses through the off-gas system, but not too close to the boiling point of trioxane (115 °C).  The melting point of the solvent should be well below room temperature to avoid solidification in the process.  The “miscibility gap” (for water and the solvent) must be broad to get good separation of both liquids1.

1 The miscibility gap is the area within the coexistence curve of an isobaric phase diagram (temperature vs composition) or an isothermal phase diagram (pressure vs composition). A miscibility gap is observed at temperatures below an upper critical solution temperature

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• The solvent-water partition coefficient of trioxane must be of a value where a high proportion of trioxane enters the solvent phase (rather than the water phase). • The solvent-water partition coefficient of formaldehyde must be such that the formaldehyde remains in the water. • The solvent should have a lower boiling point than trioxane which is beneficial for the separation from the trioxane and also to the recirculation of the solvent. • The volatility of traces of water with the alternative solvent must be high to ensure that water is not distilled together with trioxane. • The alternative solvent should be compatible with the waste gas incineration system and losses of the solvent should be small.

The above parameters are relevant to the investigation of alternative solvents for use in BASF’s existing plant, and provided a basis for investigation of alternative solvents. Other possible alternatives include alternative technologies for the production of pure trioxane, such as pressure-swing distillation and crystallisation. These are also considered in the analysis of alternatives.

3.2 Market and business trends including the use of the substance

3.2.1 Annual tonnage of EDC Average annual tonnage for the use: 60 tonnes per year.

Approximately 60 tonnes of EDC needs to be replaced annually, resulting from losses to the closed off-gas incineration system, as well as loss through reaction with sodium hydroxide which is used as a neutralisation agent in the process. The total inventory of EDC on the Ultraform® plant at any one time is in the range of [Claim #1] tonnes.

The Ultraform® plant operates at close to capacity. Therefore, the quantity of EDC used is not expected to increase in the future. Likewise, the quantity is not expected to decrease because of the need to maintain production near to capacity for commercial reasons taking into account current market trends and characteristics (see below).

3.2.2 Market trends for trioxane and POM Whilst EDC has recently been placed on Annex XIV of REACH, assuming that authorisation is granted, BASF does not foresee an associated reduction in the overall market for trioxane and POM (and associated use of EDC). This is because:

• BASF has already extensively investigated potential alternatives, partially as a result of requirements under the Carcinogens and Mutagens Directive (2004/37/EC) and replacement has not thus far been identified as feasible. • The EDC is not present in trioxane, the POM polymer or in finished articles at above the 0.1% w/w threshold under Article 57 of REACH, as the EDC is removed from the trioxane by distillation. BASF does not therefore expect any commercial pressures to replace use of EDC related to the requirements for substances in articles under REACH (supply chain communication to ensure safe use, notification to ECHA).

The production capacity of BASF’s plant in Ludwigshafen is [Claim #1] of POM, with actual production of [Claim #1] in 2013. Around 80% of BASF’s sales of POM in 2013 were to European customers ([Claim #1] in 2013), with around 2% exported to North America and around 17% exported to Asia. BASF’s sales of POM to Western and Central Europe represent around [Claim #1] of the estimated 253,000 tonnes market in 2013 (IHS Chemical, 2014).

In terms of competitors, BASF is one of four major producers of POM in Europe. POM products on the market are either in the form of homopolymer (H-POM) or co-polymer (C-POM), representing around 20% and 80% of the market respectively. BASF is the 2 nd largest producer of C-POM in Europe.

(UCST) or above the lower critical solution temperature (LCST). Its location depends on pressure. In the miscibility gap, there are at least two phases coexisting. (Source: IUPAC Compendium of Chemical Terminology – the Gold Book.)

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In terms of trends, the market for POM is becoming increasingly fragmented and is currently suffering from oversupply, with global demand in 2013 of around 1.1 million tonnes (and expected growth of 3.3% CAGR between 2012 and 2020 (Ceresena, 2013)), compared to global capacity of 1.6 million tonnes (IHS Chemical, 2014). It is understood that around 230,000 tonnes of additional capacity is currently under construction in Saudi Arabia (50,000t) and China, the latter of which is focusing on POM as a ‘strategic material’, where the intention is to meet indigenous demand with indigenous production.

The increasingly competitive market means that any temporary cessation in production and/or increased cost associated with implementing an alternative would likely affect market share and competitiveness given the oversupply and increased production in Asia. However, it is of note that BASF’s products are also understood to be of superior quality to some of the POM produced and used in Asia. While POM from such sources is not considered technically suitable for some of the users of BASF’s POM (e.g. in the transportation industry), it could be a potential replacement in some of the other.

POM production remains a profitable part of BASF’s business, and one which BASF is strategically committed to. However, profitability (EBITDA) values over recent years have declined due to the economic downturn, after which they recovered, but then declined again in 2013. The latest decline reflects increases in raw material costs that could not be passed on to customers, as well as price pressure from imports to the EU market, primarily from Asia.

The figure below provides details of EBITDA for the Ultraform® (POM) business over the period 2002-2013) for Europe and the ‘rest of world’ zone. EBITDA in 2013 was [Claim #1].

Figure 3 EBIT for BASF Ultraform Business in Europe and RoW zone [Claim #1].

In terms of total global sales (i.e. also including North America and Asia, in addition to the above), the table below provides details of sales volumes and net sales value, as well as EBITDA, for the period 2009-2014, with forecasts to 2018.

Table 1 Sales volume, value and profitability of Ultraform® plant [Claim #1].

These figures also illustrate the importance of the global market for sales from BASF’s Ludwigshafen plant.

Overall, while the global market is increasingly competitive, the POM business is expected to remain an important and profitable business line for BASF. Continued use of EDC is considered necessary for unhampered continuity of this business unit. 3.3 Remaining risk of the “applied for use” scenario

3.3.1 Overview This section presents the differences between the “applied for use” and “non-use” scenarios in terms of emissions, exposure and risks relating to EDC and possible alternatives. The human health and environmental endpoints affected are also identified.

This analysis is focused on risks to workers at BASF’s plant in Ludwigshafen, involved in production/purification of trioxane and associated activities. In line with the guidance on authorisation applications, the analysis is limited to the risks to human health and/or the environment arising from the intrinsic properties specified in Annex XIV. In this case the intrinsic property of EDC referred to in Article 57 of the REACH regulation is its classification as carcinogenic (category 1B).

While this endpoint was considered in the registration CSR, the excess cancer risks associated with exposure for the use applied for have been assessed in accordance with the dose response relationship published by the Committee for Risk Assessment

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The following risks are not considered in detail:

 Risks to the environment (aquatic, terrestrial, as well as secondary poisoning). These were shown in the registration CSR to be acceptable and are not related to the Annex XIV endpoint.  Risks to further downstream users/processors or to consumers. EDC is only present in trace amounts in the purified trioxane and any presence in the POM itself or related products will be negligible.  Risks for humans exposed via the environment e.g. through local exposure to atmospheric releases. These releases are effectively destroyed by the plant’s incinerator. This is demonstrated through a mass balance calculation below.

3.3.2 Risks to workers of the applied for use The individual risks to workers were considered in the CSR. The following assumptions are applied to the assessment of remaining risks for the use as a whole.

In terms of numbers of workers exposed:  During normal operation of the trioxane purification plant, four workers are on shift. Typically, at any one time one worker will be working at the plant and potentially exposed, with the others in other parts of the plant (e.g. the control room). In total, 21 workers are allocated to the plant’s operation team, and as a worst case, it is assumed that they are all potentially exposed.  Samples are taken and analysed in the plant laboratory. Four workers are based in the laboratory.  A further 10 workers are involved in scheduled maintenance. This maintenance involves short-term exposure; however the workers wear extensive personal protective equipment where potential for EDC exposure could occur.  Therefore, in total up to 35 workers could be considered as being potentially exposed.

In terms of exposure levels:  In terms of normal operations, measurements undertaken by BASF indicate exposure levels below the detection limit for the equipment used (0.01 mg/m3 over 8h both in the monomer plant itself and in the laboratory, based on personal samplers and stationary samplers respectively). Details of analytical techniques used are provided in the CSR.  As a worst case, it is assumed that inhalation exposure during normal operations is at the detection limit of 0.01 mg/m3.  Exposure during emergency maintenance can potentially be higher and BASF’s monitoring covers such an instance (which might happen e.g. once a month), with inhalation exposure measured at 0.11 mg/m3 over 8h. In such instances personal protective equipment is applied, including respiratory protection (part of a chemical protection suit), which is estimated to reduce exposure by over 97.5% (see further details in the CSR), leading to actual exposure of 0.003 mg/m3, which is lower than that assumed for normal operations (0.01 mg/m3). For ease of analysis, exposure during these maintenance activities is assumed to occur at the same level as for other activities (i.e. at the detection limit of 0.01 mg/m3).  As set out in the authorisation CSR, dermal exposure is not considered to be relevant to this use, based on the personal protective equipment applied, and the associated management, maintenance and training procedures. However, for the purposes of sensitivity testing, the highest modelled dermal exposure of 0.000429 mg/kg-bw/day is used, representing the potential exposure during taking of samples for quality testing.

Based on the above, the following estimates are made of the total excess cancer risks across the workforce involved in trioxane purification:

 As a worst-case, 35 workers are assumed to have inhalation exposure at 0.01 mg/m3 for 8h every shift, over a working lifetime. BASF concludes in the authorisation CSR that dermal exposure is not relevant for this use. However, for the purposes of sensitivity testing, maximum (average) dermal exposure, associated with quality sampling, of 0.000429 mg/kg bw/day is assumed.  For inhalation exposure, the excess cancer risk is estimated at 6 x 10-7 per µg/m3 (ECHA, 2015).  For dermal exposure, the excess cancer risk is estimated at 9.0 x 10-7 per µg/kg bw/day (assuming 50% absorption) (ECHA, 2015).  The excess cancer risk for one person is thus 6.0 x 10-6 for inhalation exposure. If dermal exposure is added (for sensitivity testing), the associated excess cancer risk is 9.0 x 10-7 for dermal exposure, giving 6.9 x 10-6 in total.

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For the worst case 35 workers assumed, this translates to a total excess lifetime cancer risk for the use as a whole of 2.1 x 10-4 (2.4 x 10-4 if dermal exposure is included).

As set out in the CSR, more refined estimates can be developed to take into account the fact that not all workers will be present in parts of the plant where exposure can occur. If this is taken into account the total excess lifetime cancer risk for the use as a whole is estimated as 3.6 x 10-5 (based on an average 6.7 workers exposed, taking into account the time spent in parts of the plant with potential for exposure to EDC). If dermal exposure is included, the risk is 4.1 x 10-5.

Note that the above individual risk estimate of 6.0 x 10-6 is within the current ”acceptable risk” interim level of 4 x 10-4, and also the acceptable risk level that applies from 2018 of 4 x 10-5, under the relevant German regulation under which BASF is regulated2. In any case, this estimate of the level of risk is an overestimate because it assumes that inhalation exposure is at the detection limit of 0.01 mg/m3 whereas in reality measurements demonstrate that actual exposure is below the detection limit.

3.3.3 Risks for humans exposed via the environment The trioxane and POM (Ultraform®) plant are connected to a thermal oxidiser / incinerator (off-gas combustion system). This incinerator was specifically designed for EDC (and additional chemicals present in the off-steam).

All off-steams of all different parts of the plant are collected to the incineration system. Following incineration at 1000 °C, HCl is generated from the EDC, which can be detected using pH as a proxy (H+ and Cl- equivalent). Using a mass balance approach, BASF have used this proxy relationship to estimate the amount passed to the incinerator each year as around 50-60 tonnes, which is comparable to the quantity of EDC added to the plant each year3. The incinerator includes a washing plant and a steam boiler. The steam (= the energy) is further used in the plant.

Given that the incinerator (a) collects EDC from all of the equipment within the plant; (b) leads to effectively complete destruction of the EDC, it is concluded that any quantities released to the receiving environment will lead to only very small exposure for the surrounding population (these are expected to be negligible). In order to estimate the potential scale of risks to people outside the Ultraform® plant from releases to air from the plant, exposure of people within a 1 km2 area around the plant was estimated (with values consistent with air monitoring undertaken around the plant, specifically for this authorisation application; note that this is within the overall 10 km2 Ludwigshafen site, so exposure will be to workers, rather than the general public). Based on this analysis the calculated excess cancer risk to people outside the plant is 2.7 x 10-6 across 3921 workers, over 40 years. However, this value is considered to be an overestimate, because for example, the modelling used to calculate emissions from the incinerator assumed a higher release rate of EDC than actually occurs in practice. This is described further in the CSR. 3.4 Human health and environmental impacts of the applied for use scenario The previous section presented a quantification of the health effects of the applied for use scenario. In the “non- use” scenario, exposure of the workers concerned would no longer occur. There would therefore be a reduction in excess lifetime cancer risk equivalent to that calculated above, i.e. 2.1 x 10-4 across the whole of the exposed workforce as a worst case (3.6 x 10-5 when occupancy in areas relevant to exposure is taken into account), over 40 years’ exposure. It should be reiterated that this is a maximum value, as it assumes that exposure is at the detection limit of the analytical method, whereas in reality exposure is lower.

2 Technical Rules for Hazardous Substances: Risk-related concept of measures for activities involving carcinogenic hazardous substances (TRGS 910, English Version), February 2014. This refers to a working lifetime of 40 years and exposure for 8h every working day which is equivalent to the time worked by staff at BASF's Ultraform plant.

3 It is not feasible to directly measure EDC passing to the incinerator. Therefore, the pH of the wastewater from the incinerator is used as a proxy, as follows: pH of the water added to the incinerator is neutral (pH 7). In the wastewater from the incinerator, pH is on average 1.78, indicating that the concentration of protons generated by destruction of EDC and formation of HCl is [H3O+] (mol/l) = 10 ^ -pH. Since 1 mol of EDC generates 2 mol of HCl / protons, this equates to 0.0083 mol/l of wastewater. With a flow rate of 8 m3/h, operation over 11 months per year (24h per day), and a molecular weight of 98.96 g/mol, this equates to around 53 tonnes of EDC per year.

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For sensitivity testing purposes, if the calculated dermal exposure is included, the reduction in excess lifetime cancer risk would be 2.4 x 10-4 across the whole of the exposed workforce as a worst case (4.1 x 10-5 when occupancy in areas relevant to exposure is taken into account).

In addition, based on the above values, the excess cancer risk for humans exposed via the environment is calculated as 2.67 x 10-6 across 3921 workers, over 40 years.

3.5 Monetised damage of human health and environmental impacts As a basis for comparison with the economic and other costs of the “non-use” scenario, the damage to human health associated with the risks to workers from the applied for use has been calculated in monetary terms.

In February 2015 ECHA published a study examining the economic value of the benefits of avoiding certain adverse health effects from chemicals. This study includes carcinogenicity, as well as a number of different endpoints. This study estimated the “willingness to pay” for reducing the chance of getting cancer, expressed as a Value of Statistical Case of Cancer (VSCC), as well as, based on the associated probability of dying, the derivation of a Value of a Statistical Life (VSL). These values are summarised in the table below.

Table 2 ECHA estimates of benefits of avoiding cancer

Parameter WTP Value of a statistical case of a cancer (VSCC) €396,000 Value of a statistical life for cancer (VSL) €5,000,000 Note: Willingness to pay (WTP) is expressed in 2014 Euro prices expressed based on a ‘purchasing power standard’. Source: Alberini and Ščasný (2014).

The intention of this study was to derive representative EU-wide reference values that ECHA and other bodies can use when carrying out economic analyses in connection with the REACH Regulation. These values are therefore used in the current study, although methodological challenges are noted and hence uncertainties with precise monetary estimates are recognised. For comparison, they compare reasonably well with – albeit being at the higher end of – a range of other estimates for the WTP for a VSL related to death from cancer. For example:

 IOM, AMEC and Imperial (2011) estimated a value of €1.9m as a value for WTP to avoid fatal cancer (€1,768,256 in 2009 prices).  The UK Health and Safety Executive (HSE, n.d.) gives an estimate of €4.9 million for the valuation of a fatality (£1,336,800 GBP per fatality, but double this for cancer, 2003 prices).  The European Commission (2000) includes an estimate of €2.0 million for the value of preventing a fatality (range €1.4 to €5.1 million) (original data €1.5m with range of €1.0-€3.8m for fatalities with a cancer premium, 2000 prices).  The OECD (2012) give a value of €3.5 million (range €1.7 to €5.2 million) for valuation of mortality ($3.6m with range of $1.8m to $5.4m USD, 2000 prices).

The above values are all converted to 2014 Euro values using historical exchange rates (annual average) from the ECB and the EU harmonised index of consumer prices.

Based on the above, a valuation of €5 million per cancer incidence seems to represent a reasonable, conservative estimate of the value of a statistical life for cancer (i.e. an estimate towards the higher end of the spectrum).

Translating the quantitative estimate of cancer risk from above into a monetary value using this data point suggests a maximum value of worker health impacts due to cancer of:

 (2.1 x 10-4) x (€5 million) = €1,050 assuming all 35 workers are exposed at the maximum level, related to inhalation exposure.  (2.4 x 10-4) x (€5 million) = €1,208 assuming all 35 workers are exposed at the maximum level, if dermal exposure is also taken into account (for sensitivity testing purposes).

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The above estimate, based on the ECHA risk estimates, relates to working lifetime exposure over a 40 year period. BASF’s workers at the POM plant work the equivalent of a typical full-time shift.

The above is considered to be an overestimate for a number of reasons:

 Worst-case assumptions have been made about the number of people exposed (i.e. all workers at the plant, including laboratory and control room staff are included).  The health risks related to full (working) time exposure over 40 years. In reality most workers will not be exposed for so long, hence reducing the overall level of risk.  Similarly, the results have not been scaled (reduced) to take into account the fact that exposure would only occur over the duration of the authorisation period, rather than 40 years.

As set out in the CSR, the more realistic estimate of exposure gives a lower level of excess cancer risk which suggests a value of worker health impacts due to cancer of:

 (3.6 x 10-5) x (€5 million) = €179 related to inhalation exposure  (4.1 x 10-5) x (€5 million) = €206 if dermal exposure is also taken into account for sensitivity testing purposes (i.e. inhalation and dermal exposure combined)

If exposure of humans via the environment is also taken into account, the additional monetary value of the excess cancer risk is: (2.67 x 10-6) x (€5 million) = €13.

These values are taken into account in Section 5 on the impacts of (not) granting an authorisation. Note that the above estimates include the risks related to inhalation and dermal exposure, though in reality BASF has demonstrated that the risks associated with dermal exposure are negligible.

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4. SELECTION OF THE “NON-USE” SCENARIO

4.1 Efforts made to identify alternatives

4.1.1 Research and development BASF’s research and development to find an alternative to EDC for trioxane purification has focused, primarily, on alternative solvents to EDC for use in the extraction unit of the trioxane production plant. However, research into alternative techniques for trioxane production has also been undertaken, as outlined in the section below on data searches.

BASF’s starting point for the identification of an alternative solvent was interrogation of an internal database of potential alternative solvents. This includes 7,200 different chemicals, characterised according to their physicochemical parameters, or from experimental data (see Appendix A).

A first screening step for these solvents involved screening against the following criteria, which can be compared to the functional requirements in Section 3.1.3 of this document.

Table 3 Initial screening/exclusion criteria for possible alternative solvents

Exclusion criteria Exclusion criteria Parameter Unit EDC (medium-boiling (light solvents) solvents) Miscibility gap for solvent gML 215 Below 5 Below 5 and water Mass-related partition KTri 3.8 < 1 < 1.5 coefficient of trioxane Mass-related partition KFA 0.11 - - coefficient of formaldehyde Relative volatility (solvent in RV_S_water 582 - - water) Relative volatility (solvent / RV_S_Tri (a/b) 2.1 / 3.0 < 0.1 < 1.0 trioxane) Vapour pressure p (hPa) @ 373K 1650 - - Solvent melting point °C -36 < 0 < 0 Solvent normal boiling point °C 84 < 90 < 110 Sources: BASF internal document “search for an alternative solvent”; BASF report “solvent screening for the extraction of trioxane” (114.0715.11l, 31 October 2014). Note "-" means that the criterion was not used in the initial screening.

The above exclusion criteria were applied as follows:

 For light solvents, there were around 6,000 substances that fulfilled the miscibility gap, melting point and boiling point criteria. Around 910 fulfilled the KTri and RV_S_Tri criteria, of which around 670 were those with a vapour pressure correlation and 240 without. These were subjected to an individual review of thermodynamic data, more detailed review of volatility and chemical stability (when used with formaldehyde and sodium hydroxide solutions). Those that were expected to be unstable were excluded, yielding a list of around 130 substances for further more detailed assessment. These comprised five groups: hydrochlorofluorocarbons, aromatics, ethers, esters and others.

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 For medium-boiling solvents, technical performance would be inferior, with loss of product and lower recovery efficiency of trioxane. Again 6,000 substances passed the miscibility gap, melting point and boiling point criteria and in this case around 500 fulfilled the KTri and RV_S_Tri criteria. Following more detailed individual review, as above, just over 100 substances were identified for more detailed assessment. These comprised the following groups: (1) phenols and alcohols, (2) anilines and pyridines, (3) aromatics, hydrochlorofluorocarbons and nitro compounds, (4) esters, (5) nitriles, ketones and ethers.

Appendix B provides a copy of the approach to the initial screening as well as the approach by which candidate substances were screened and tested for NaOH stability and for the potential disruption of polymer synthesis. Subsequent screening was done by a BASF expert panel in the course of 3 workshops, using – in addition to the physical and physicochemical data – the rules of stability and reactivity of functional groups, well known from organic chemistry for the reaction conditions in different relevant steps of the trioxane and the POM process in question, as already described elsewhere in this document.

The next stage of screening involved analysis of the short-listed solvents against the following criteria:

 Toxicological/ecotoxicological and physicochemical hazard assessment.  Laboratory experiments to further test suitability.  Evaluation of compatibility with existing hardware.  Availability on the market and price.  Likely costs of modifying the plant.  Chemical stability in all of the processes that are involved.

On the basis of this screening, the four most potentially suitable candidate substances were identified as: benzene, dichloromethane, N-butyl-methyl-ether and isoflurane. In practice, these four alternatives were hence selected primarily on the basis of technical feasibility.

In theory, BASF could undertake further laboratory testing of these potential alternatives. However, based on current information BASF considers that these are not suitable alternatives for use in the trioxane purification process, and hence this would not be undertaken in practice. This is further demonstrated below, in the detailed analysis of specific potential alternatives.

4.1.2 Data searches In addition to the use of possible alternative solvents in the existing plant, a number of other potential alternative techniques are available, identified by BASF’s market intelligence as well as review of relevant literature including patents. Two possible alternative techniques have been identified:

 Crystallisation. The purification of trioxane through crystallisation starts with the homogeneous solution of trioxane, water, formaldehyde and smaller concentrations of by-products in water. This mixture is fed to the crystallisation vessel where it is cooled down, typically using cooling water running through the jacket of the vessel. As the temperature decreases, the solubility of trioxane also decreases. When the solubility reaches the actual concentration, pure trioxane precipitates in the vessel. At the end of the process a solid (trioxane particles) - liquid slurry is obtained. The trioxane particles are filtered from the liquid and washed to remove impurities that remain on the surface. The crystallisation technique is known to be used by competitors of BASF in the EU. BASF has itself evaluated this technique up until 2005, but abandoned it due to economical infeasibility and uncertainty of quality of trioxane.

 Pressure swing distillation. This process involves overcoming the azeotrope formed from trioxane, formaldehyde and water, by carrying out a first and then a second distillation at different pressures. In the first distillation column, operated at lower pressure, the mixture is separated into a trioxane/water mixture with low formaldehyde content, and a largely trioxane-free formaldehyde/water mixture. In the second distillation column, operated at higher pressure, the trioxane/formaldehyde/water mixture is separated into pure trioxane and a trioxane/formaldehyde/water mixture having a lower trioxane content4. This technique was evaluated by BASF starting in 2002 and finishing in 2008.

4 Removal of trioxane from a trioxane/formaldehyde/water mixture by means of pressure-swing rectification, Patent number CA 2673572 A1.

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As with the potential alternative solvents identified by BASF, these techniques are not considered to be suitable or available to BASF, in this case due to technical feasibility (for implementation at Ludwigshafen and in relation to the quality of the finished POM) and also economic feasibility issues. Again, these are described in more detail in the following sections. 4.2 Identification of known alternatives The preceding sections outline a number of technical criteria that were identified in screening and assessing potential alternatives to EDC for trioxane purification. In addition to these, a number of economic considerations are relevant, with those identified by BASF being:

 Any modification to the plant should involve short downtime and low costs.  The overall fixed and variable costs for plant operation should be comparable to (or less than) the process involving EDC.  The energy costs should be comparable or lower.  The alternative solvent should be readily available on the market from a number of suppliers.  Alternative solvents should have comparable or lower price than EDC.

These criteria, as well as criteria related to the relative hazards of the alternative, have been taken into account in BASF’s conclusion that there is currently no suitable alternative substance or technique to replace EDC in trioxane purification.

Neither the identified alternative solvents, nor the alternative processes are considered suitable for BASF. The non-use scenario, for each link in the supply chain, is concluded to be as follows:

 BASF: Without an alternative, BASF would no longer be able to produce trioxane in a form suitable for polymerisation to POM. As such, the expected non-use scenario in the event that authorisation is not granted would be the closure of the trioxane monomer (purification) plant. Since BASF’s POM business is integrated within the site, the non-use scenario would also involve closure of the polymerisation (POM) plant. This non-use scenario has been confirmed by the senior management of BASF’s performance materials division, one of 14 BASF divisions.  In theory, one option would be for BASF to stop trioxane production and simply buy the substance from external suppliers, for use in the polymerisation plant. However, this is not possible: all POM plants globally have their own monomer production because the polymerisation process results in formation of trioxane monomer as well as well as formaldehyde (trioxane is a trimer of formaldehyde), and these need to be recycled back into the trioxane process.  In theory, it might be possible for BASF to construct a replacement plant, using an alternative technology for trioxane production/purification (e.g. crystallisation). However, in addition to being prohibitively expensive, this would not be technically feasible before (or any time soon after) the sunset date, as BASF does not have commercial access to the technology. Due to the associated time between ceasing production (at the sunset date, without an authorisation) and bringing any new plant into commercial production, it is expected that BASF would lose its market share and would not be able to recover the business. Therefore, construction of a new trioxane production/purification plant would not be undertaken by BASF.  POM processors: Companies processing POM into finished products would need to source their POM from elsewhere. It is expected that they would source POM from a combination of European and non- European (primarily Asian) competitors.  Finished product manufacturers: Due to the diverse range of end-products using the POM, there is no single non-use scenario. However, since POM is never a “commodity” product, all end users would need to requalify/retest their products to some extent (with the ‘new’ POM). Whilst some products might be relatively quick to requalify, others would require substantial time and effort (e.g. safety buckles and seat belt stop mechanisms).

The following sections demonstrate that the shortlisted alternatives are not suitable for replacement of EDC at the present time. The six alternatives described are:

 Alternative solvents: benzene, dichloromethane, N-butyl-methyl-ether and isoflurane.  Alternative techniques: crystallisation and pressure swing distillation.

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It should be noted that the only ones of these that are in commercial use (in addition to use of EDC for extraction) are use of benzene as the solvent and use of the crystallisation technique.

4.3 Assessment of shortlisted alternatives

4.3.1 Alternative 1 – Benzene

4.3.1.1 Substance ID, properties A number of key properties for benzene are highlighted in the table below. This includes various parameters that are of relevance in the context of potential replacement of EDC.

Table 4 Key properties for benzene

Parameter Value (value for EDC) Substance identity Chemical name Benzene CAS number 71-43-2 EC number 200-753-7 Key properties Vapour pressure, p (hPa) @ 373K 1801 (1650) Melting point, °C 6 (-36) Normal boiling point, °C 80 (84) Miscibility gap for solvent and water, gML 909 (215) Mass-related partition coefficient of trioxane, KTri 1.6 (3.8) Mass-related partition coefficient of formaldehyde, KFA 0.10 (0.11) Relative volatility (solvent in water), RV_S_water 2872 (582) Relative volatility (solvent in trioxane), RV_S_Tri (a/b) 6.1 / 1.1 (2.1 / 3.0) Hazard classification (harmonised) Human health hazard classification Asp. Tox. 1 H304 Skin Irrit. 2 H315 Eye Irrit. 2 H319 Muta. 1B H340 Carc. 1A H350 STOT RE 1 H372 Environmental hazard classification - Physicochemical hazard classification Flam. Liq. 2 H225

4.3.1.2 Technical feasibility of Alternative 1 BASF understands that all major Asian and North American producers of C-POM use benzene as the industrial solvent in their extraction process for trioxane. Worldwide it is considered the standard solvent for use in trioxane purification, though not in the EU.

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Nonetheless, use of benzene would require some plant modifications, as BASF’s trioxane purification plant has been optimised for use of EDC. Trioxane is expected to partition better into EDC as an extraction solvent than into benzene (based on the KTri value).

4.3.1.3 Economic feasibility and economic impacts of Alternative 1 In theory benzene could be used as an alternative extraction solvent for trioxane purification. The specific details of its economic feasibility have not been investigated in detail, however, the following cost impacts would apply:

 The price of EDC on the wider market was on average around €290 per tonne in 2014 (ICIS, 2015), although BASF currently sources EDC produced internally within the Ludwigshafen site. The price of benzene fluctuates significantly with the crude oil price but ranged from under €500/t to over €1100/t in 20145.  Some plant modifications would be required in order to use benzene. These have not been assessed in detail.  BASF would incur costs associated with ensuring customer acceptability for the final POM product, due to the expected difference in physical properties.

Use of benzene could be economically feasible. However, since its use would not be acceptable as a replacement for EDC (see Section 4.3.1.5 below), this is not a viable option for BASF.

4.3.1.4 Availability of Alternative 1 Benzene is widely available on the market.

4.3.1.5 Hazard and risk of Alternative 1 The key disadvantage of benzene is that it is a category 1A carcinogen (EDC is a category 1B carcinogen). Because exposure is likely to be comparable to EDC (as the screened alternatives have reasonably similar physicochemical properties), use of benzene is not expected to result in lower risks compared to EDC.

Benzene meets the criteria for qualification as a SVHC under REACH (category 1A CMR substance). Therefore, from a regulatory point of view, substitution is not considered sustainable, as its use as a solvent might be subject to authorisation in the future.

Prior to the listing of EDC in Annex XIV of REACH, BASF has considered the potential for use of benzene as an alternative solvent. Under the German Technical Rules for Hazardous Substances (TRGS 600)6, set by the Federal Ministry of Labour and Social Affairs, substitution must be implemented for substances such as EDC if alternatives are technically practicable and lead to an overall lower risk to workers. Any substitution must as a whole reduce the hazards arising from hazardous substances at the workplace. It is assumed that substitution of a category 1B carcinogen (EDC) with a category 1A carcinogen (benzene) would not meet this requirement, and would therefore not be permitted.

4.3.1.6 Conclusions on Alternative 1 Benzene is a technically feasible alternative solvent, and is used worldwide outside the EU for purification of trioxane for POM production. Because of its similar hazardous properties and regulatory issues, benzene is not a substantial improvement over the present situation and thus is not considered.

4.3.2 Alternative 2 – Dichloromethane (DCM)

4.3.2.1. Substance ID, properties, and availability A number of key properties for dichloromethane are highlighted in the table below. This includes various parameters that are of relevance in the context of potential replacement of EDC.

5 Based on Platt’s global benzene price index, values have ranged from around $625 to $1500 USD over the course of 2014 (http://www.platts.com/news-feature/2014/petrochemicals/pgpi/benzene).

6 http://www.baua.de/en/Topics-from-A-to-Z/Hazardous-Substances/TRGS/pdf/TRGS-600.pdf?__blob=publicationFile&v=3.

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Table 5 Key properties for dichloromethane

Parameter Value (value for EDC) Substance identity Chemical name Dichloromethane (methylene chloride) CAS number 75-09-2 EC number 200-838-9 Key properties Vapour pressure, p (hPa) @ 373K 5820 (1650) Melting point, °C -95 (-36) Normal boiling point, °C 40 (84) Miscibility gap for solvent and water, gML 100 (215) Mass-related partition coefficient of trioxane, KTri 6.8 (3.8) Mass-related partition coefficient of formaldehyde, KFA 0.13 (0.11) Relative volatility (solvent in water), RV_S_water 837 (582) Relative volatility (solvent in trioxane), RV_S_Tri (a/b) 5.8 / 16.2 (2.1 / 3.0) Hazard classification (harmonised) Human health hazard classification Carc. 2 H351 Environmental hazard classification - Physicochemical hazard classification -

4.3.2.2. Technical feasibility of Alternative 2 BASF understands that at least one competitor abandoned this technology because of technical and environmental difficulties.

DCM has a much lower boiling point than EDC. As a result, more pressure-resistant equipment would be needed as compared that for use of EDC. BASF also expects that brine cooling would be required, and that hole corrosion on condensing areas would occur (with the acidic conditions in work-up, phosgene and HCl are generated; the HCl with water leads to hole corrosion).

4.3.2.3. Economic feasibility and economic impacts of Alternative 2 The price per kg of DCM was on average €358 per tonne in Europe in 2014 (ICIS Pricing, 2015), which is higher than the price of EDC on the open market (€290 per tonne in 2014). There would therefore be an additional cost associated with using DCM. However, the most significant cost associated with use of DCM would be the alternative and additional equipment needed in order to operate the extraction process (as noted above). DCM is not considered to be economically feasible, because of its technical limitations, as well as the costs associated with the modifications to equipment that would be required.

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4.3.2.4. Availability of Alternative 2 DCM is widely available on the market. It is registered under REACH at 100,000 to 1,000,000 tonnes per annum and sales in Europe have recently been confirmed as over 100,000 tonnes per year7.

4.3.2.5. Hazard and risk of Alternative 2 DCM is classified as a category 2 carcinogen, whereas EDC is a category 1B carcinogen. However, it is considered feasible that DCM may also be given a more stringent classification for carcinogenicity in the future. It is therefore not considered to be suitable in terms of human health hazards. Because exposure is likely to be comparable to EDC (as the screened alternatives have reasonably similar physicochemical properties), the risks are also not expected to be significantly different to those of EDC.

4.3.2.6. Conclusions on Alternative 2 DCM could not be used in BASF’s existing equipment and, whilst technically feasible in theory, would require substantial modifications to the existing plant, which would also be highly costly. However, the main reason for concluding that DCM is not a suitable alternative is its classification as a category 2 carcinogen, with the potential for future classification comparable to EDC. In essence, it is unlikely to represent a lower hazard/risk substance than EDC.

4.3.3 Alternative 3 – N-butyl methyl ether

4.3.3.1. Substance ID, properties, and availability A number of key properties for N-butyl methyl ether are highlighted in the table below. This includes various parameters that are of relevance in the context of potential replacement of EDC.

Table 6 Key properties for N-butyl methyl ether

Parameter Value (value for EDC) Substance identity Chemical name N-butyl methyl ether (1-methoxybutane) CAS number 628-28-4 EC number 211-033-7 Key properties Vapour pressure, p (hPa) @ 373K 3287 (1650) Melting point, °C -116 (-36) Normal boiling point, °C 70 (84) Miscibility gap for solvent and water, gML 490 (215) Mass-related partition coefficient of trioxane, KTri 1.2 (3.8) Mass-related partition coefficient of formaldehyde, KFA 0.40 (0.11) Relative volatility (solvent in water), RV_S_water 2287 (582) Relative volatility (solvent in trioxane), RV_S_Tri (a/b) 15.7 (2.1 / 3.0) Hazard classification (harmonised) Human health hazard classification -

7 104,000 tonnes in 2011 according to Eurochlor: “Chlorinated Solvents Market 2011 went down after recovery in 2010”, press release, Monday, June 25, 2012

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Environmental hazard classification - Physicochemical hazard classification None. Notified classification as: Flam. Liq. 2 H225

It is of note that, while N-butyl methyl ether was pre-registered under REACH, it has not been registered.

4.3.3.2. Technical feasibility of Alternative 3 N-butyl methyl ether has a lower density (0.75 g/cm3 at 25°C) than EDC (1.25 g/ cm3 at 25°C). Because of this, BASF expect that the substance could form an (unacceptable) emulsion if used as a replacement solvent, on inappropriate loading of the extractant, i.e. it is a less stable process due to the similarity of the density to that of water.

Furthermore, the substance has lower selectivity than EDC i.e. the extent to which it dissolves trioxane is lower, based on the KTri value from above. As a result, BASF estimates that around three times the volume of solvent would be required overall, resulting in the need for much larger equipment, and extensive modification of the monomer plant.

Overall, therefore, the substance is concluded to be not technically feasible for BASF, at least in the existing plant.

4.3.3.3. Economic feasibility and economic impacts of Alternative 3 BASF’s procurement department have tried to find a commercial supplier of N-butyl methyl ether but to date none has been identified. While there are various suppliers of very small quantities for laboratory use, there are no identified suppliers providing the quantities likely to be required by BASF. In particular, the substance has not been registered under REACH (as of February 2015), implying that less than 100 tonnes is placed on the market per year by any one supplier. This compares to around 60 tonnes of EDC required by BASF, with approximately three times the quantity of N-butyl methyl ether expected to be needed.

No attempt has been made to quantify the economic impacts given that no commercial supplier has been identified. Even if sufficient quantities could be obtained, there would be significant costs associated with making major modifications to the existing trioxane plant, likely to be a substantial proportion of the costs associated with redevelopment of the plant (considered under alternatives 5 and 6).

At present, therefore, the substance is concluded to be not economically feasible for BASF.

4.3.3.4. Availability of Alternative 3 As indicated above, no commercial suppliers of N-butyl methyl ether have been identified. Therefore, the substance is not available as an alternative to BASF.

4.3.3.5. Hazard and risk of Alternative 3 N-butyl methyl ether does not have harmonised classification under the CLP Regulation, with only notified classification as a category 2 flammable liquid. There is therefore no indication that it is of equivalent or greater hazard compared to EDC. However, the low quantities on the market may also reflect less effort undertaken to study the hazardous properties of the substance i.e. there are more data gaps for N-butyl methyl ether than for EDC.

4.3.3.6. Conclusions on Alternative 3 N-butyl methyl ether would have substantial technical drawbacks compared to EDC, and furthermore is not available on the market in sufficient quantities to replace EDC. Even if it were possible to use the substance, substantial modifications would be needed to BASF’s plant in order to use the substance. The hazard classification does not suggest particular concern (other than flammability), but it is likely that the evidence on health and environmental hazards is substantially less than that for EDC (e.g. no information through REACH registrations is available).

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4.3.4 Alternative 4 – Isoflurane

4.3.4.1. Substance ID, properties, and availability A number of key properties for isoflurane are highlighted in the table below. This includes various parameters that are of relevance in the context of potential replacement of EDC.

Table 7 Key properties for Isoflurane

Parameter Value (value for EDC) Substance identity Chemical name Isoflurane CAS number 26675-46-7 EC number 247-897-7 Key properties Vapour pressure, p (hPa) @ 373K 1944 (1650) Melting point, °C -108 (-36) Normal boiling point, °C 49 (84) Miscibility gap for solvent and water, gML 816 (215) Mass-related partition coefficient of trioxane, KTri 4.0 (3.8) Mass-related partition coefficient of formaldehyde, KFA 0.04 (0.11) Relative volatility (solvent in water), RV_S_water 3095 (582) Relative volatility (solvent in trioxane), RV_S_Tri (a/b) 2.6 / 6.9 (2.1 / 3.0) Hazard classification (harmonised) Human health hazard classification None but notified classification as: Eye Irrit. 2 H319 Repr. 1A H360 Skin Irrit. 2 H315 STOT RE 2 H373 (liver) STOT RE 3 H336 (resp. tract, CNS) Environmental hazard classification - Physicochemical hazard classification - Isoflurane has been pre-registered under REACH, but not registered as yet.

4.3.4.2. Technical feasibility of Alternative 4 While isoflurane has relevant physicochemical parameters that are similar to those of EDC, it has a noticeably lower boiling point, which will mean increased potential for release to the workplace environment and would also likely necessitate process modifications.

More significantly, the substance is likely to liberate hydrofluoric acid (HF) in an industrial environment, which would be corrosive for equipment, necessitating either more robust equipment or more frequent replacement of equipment, and the potential for equipment failures e.g. leaks.

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4.3.4.3. Economic feasibility and economic impacts of Alternative 4 No commercial supplier of isoflurane for industrial use has been identified. However, based on information on supply for anaesthetic use, the price is typically around €50/kg (according to supplier enquiries by BASF procurement).

In addition to the likely increases in raw material costs, there would also be costs associated with plant modifications and/or more frequent replacement of equipment due to the liberation of HF.

4.3.4.4. Availability of Alternative 4 As indicated above, isoflurane has not been registered under REACH, and is therefore not expected to be sold onto the EU market in quantities over 10 tonnes per year. As in the case with N-methyl butyl ether, greater quantities than this would be required for its use as a replacement solvent to EDC. It is therefore concluded that isoflurane is not available in sufficient quantities to BASF.

4.3.4.5. Hazard and risk of Alternative 4 Isoflurane is not registered under REACH, and its primary use is as a general anaesthetic (NHS, 2015). Under the conditions required at BASF’s plant, the substance is also likely to liberate HF, which is highly toxic and corrosive.

There are therefore significant potential health impacts for workers associated with using isoflurane, albeit they are different from the effects of EDC. Because exposure is likely to be comparable to EDC (as the screened alternatives have reasonably similar physicochemical properties), the risks are also not expected to be significantly different to those of EDC.

4.3.4.6. Conclusions on Alternative 4 Isoflurane would have substantial technical drawbacks compared to EDC, in particular because it is expected to liberate HF, which is corrosive to equipment. The substance is an anaesthetic, and thus exposure of workers could have significant safety implications on the site. At present, the price of isoflurane is expected to be many times that of EDC. Overall, therefore, isoflurane is not considered to be a suitable alternative solvent.

4.3.5 Alternative 5 – Crystallisation (alternative technology)

4.3.5.1. Substance ID, properties, and availability The crystallisation process involves the production of high purity trioxane crystals by precipitation. There are a number of crystallisation methods for purification of trioxane, but as an example, the process could involve8:

 Addition of an amine such as triethanolamine to (less pure) trioxane in a crystallisation apparatus. The amine has a significantly higher boiling point than trioxane.

 At least one washing/sweating step.

 The process does not require solvents for extraction of the trioxane (this example mentions methylene chloride, ethylene chloride and benzene as extraction solvents, which correlates well with BASF’s findings).

The crystallisation process is used by at least one of BASF’s competitors (producers of POM) in Europe.

4.3.5.2. Technical feasibility of Alternative 5 Although BASF have not applied this process at a commercial scale, it has been investigated in the past (in the 2000s). In general terms, the crystallisation process appears to be a technically feasible one for the production of pure trioxane, for subsequent use in POM production as evidenced by its use by one of BASF’s competitors.

8 US Patent number 5401859, 28 March 1995, Hoechst AG.

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However, the same competitor is currently constructing a new POM plant in Saudi Arabia which is understood to use solvent (benzene) technology, rather than crystallisation9.

The crystallisation process is completely different to the existing for extraction and purification of trioxane as applied by BASF. In order to implement this process, BASF would need to dismantle the existing trioxane monomer plant and design, construct, and test a completely new plant. Furthermore, the effect on the trioxane polymerisation process is unclear, as there may be consequent effects on product quality (e.g. in the case of different impurities), including potential impacts on performance of final products.

Furthermore, the trioxane polymerisation process used by the competitor that applies the crystallisation process is different to BASF’s polymerisation process. If the impurities in the trioxane from the crystallisation process are different to those in BASF’s trioxane, the polymerisation process may not work effectively (e.g. BASF’s process uses an acid initiator at parts per billion levels, so impurities could readily interfere with the process).

Whilst technically feasible in theory, the crystallisation process is not considered a commercially viable option in the short term, because BASF does not have access to the technology. However, BASF continues to investigate the potential for this technology.

4.3.5.3. Economic feasibility and economic impacts of Alternative 5 A key barrier to implementation of the crystallisation process is that the process is covered by competitors’ patents. It is therefore expected that there would be a substantial cost associated with licensing this technology. Based on BASF’s experience in other fields, the license fee could typically be in the region of 2% of turnover.

The key economic impacts of this method would include:

 Costs for BASF associated with obtaining a licence to use the process (it is not currently certain whether this would be granted).

 Even if a licence to use the process were granted, there would be significant costs for BASF associated with developing a new trioxane plant including: designing and developing the production process (i.e. detailed engineering design); constructing a pilot plant and producing the resultant POM; ensuring customers’ acceptance of the product; refinement of design and construction of a full-scale plant.

 Costs for BASF associated with loss of revenue during the plant downtime period (assuming no authorisation after the sunset date, taking into account the time needed to develop the plant). It is also likely that this would lead to a long-term loss of market share for BASF, making this option unfeasible.

As a result of the costs of implementing this process, as well as technical concerns (e.g. whether the trioxane produced could be used in BASF’s polymerisation process, which is different to the competitor’s), BASF’s investigations into the process led to the abandonment of this as a potential replacement to the existing process in 2005.

4.3.5.4. Availability of Alternative 5 While the crystallisation method is available in that it is used by competitors of BASF, its use is protected by patents. It is therefore not readily available to BASF without securing (and paying for) a licence to use the process.

4.3.5.5. Hazard and risk of Alternative 5 No specific environmental or health impacts have been identified for the crystallisation process, other than the typical types of health and safety risks associated with chemical process plants.

9 A 50,000t per year POM plant in Saudi Arabia is currently being developed (ICIS News, 2010) by the company that is using the alternative “crystallisation” technique in Europe. However it is understood that the technology used for this new plant will be based on solvent extraction using benzene.

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4.3.5.6. Conclusions on Alternative 5 Although the crystallisation process is expected to be a technically viable route to the production of sufficiently pure trioxane for POM production, it is not considered to be readily available to BASF (primarily due to its protection by patents of competitors). It is also considered to be economically infeasible because of the costs of implementing this technology into production, even assuming that a licence would be granted by its proprietor.

4.3.6 Alternative 6 – Pressure swing distillation (alternative technology)

4.3.6.1. Substance ID, properties, and availability Pressure swing distillation is an alternative process for the production of pure trioxane. In the early-mid 2000s, BASF considered this technology, along with the crystallisation process. It was recognised that, with the expansion of capacity in POM production globally, it would be desirable to replace the existing trioxane process by a simpler and more economic one (Grützner et al, 2006).

The initial design concept for this approach was as follows:

 A reactor in which trioxane synthesis takes place

 A downstream column train with three distillation columns run at different pressures.

 Aqueous formaldehyde solution is fed to the reactor (R1). The resultant stream only contains low concentrations of trioxane, due to the low conversion rate.

 In column K1 (which operates at low pressure of around 1 bar, and high enough temperature to avoid solid precipitation), a trioxane rich overhead product is produced, at close to the ternary azeotrope (with the formaldehyde-rich bottom product recycled).

 In column K2, which is operated at a higher pressure (e.g. 4 bar), trioxane is obtained as the bottom product (stream 7).

 The overhead product of column K2 is separated in column K3 (intermediate pressure) into pure water and an overhead product with a composition close to the ternary azeotrope that is recycled.

This is illustrated in the figure below.

Figure 4 Schematic flow diagram for trioxane production via pressure swing distillation

Source: (Grützner et al, 2006)

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BASF has also taken out a number of patents related to this process such as:

 Method for separating trioxane from a trioxane/formaldehyde/water mixture by means of pressure change rectification (US 8350063).

 Integrated method for the preparation of trioxane from formaldehyde (US 8450507).

 Process for preparing polyoxymethylene homopolymers or copolymers by homopolymerisation or copolymerization of trioxane, starting from methanol (US 8378144 B2).

4.3.6.2. Technical feasibility of Alternative 6 BASF undertook detailed investigations of this process. This was done prior to REACH, in pursuit of a more efficient process and in identifying a possible means of substituting EDC in the context of the Carcinogens and Mutagens Directive. This was a major investment for BASF which ultimately represented a wasted investment, but it nonetheless represents BASF’s commitment to substitution.

In order to test the process, a mini-plant was constructed and the trioxane produced was evaluated for purity and quality. However, the results illustrated a substantial problem in that a high concentration of formic acid in the trioxane was produced as an side-product. According to specifications for polymerisation, less than 5ppm w/w is allowed but around 5000ppm w/w was produced in the mini-plant. In order to address this issue, possible solutions that have been evaluated were: (a) applying additional distillation steps to remove the formic acid (this would require additional distillation); (b) installation of a molecular sieve, although there is a technical challenge associated with regeneration of the sieve; (c) addition of substances methanol or DBU (an amidine) to neutralise or esterify the formic acid.

Based on the above, BASF’s evaluation led to the conclusion that the process in the diagram above is not technically feasible and the efforts to further develop the process were terminated in 2008 (after 6 years of development and €18 million spent).

In any case, the implementation of this technique for production/purification of trioxane would have required the dismantling of the existing plant and construction of an entirely new plant.

BASF therefore concludes that this technology is not technically feasible at present.

4.3.6.3. Economic feasibility and economic impacts of Alternative 6 BASF has estimated the costs associated with implementing this process as €80 million. This would primarily be associated with

 Designing and developing the (revised) production process;  Constructing a new pilot plant and producing the resultant POM;  Ensuring supply chain acceptance of the product;  Design, construction and bringing into operation the full-scale plant.

This estimate is derived based on BASF’s experience of similar projects of similar scale and complexity on the Ludwigshafen site.

Additionally, taking into account the technological problems discussed above, the investment costs to implement this alternative make it economically infeasible.

Furthermore, there would be costs for BASF associated with loss of revenue during the (significant) plant downtime period (it would take many years to implement this alternative if EDC could no longer be used in trioxane/POM production after then 2017 sunset date). It is also likely that this would lead to a long-term loss of market share for BASF.

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4.3.6.4. Availability of Alternative 6 The main starting materials for this process are the same as for the existing process (e.g. methanol, which is converted to formaldehyde and then trioxane). As it is an alternative technology, rather than an alternative substance, there is not, therefore, any problem associated with availability of chemical substances required for the process.

Unlike the crystallisation process, pressure swing distillation is not protected by competitors’ patents. However, the technology has not yet been fully developed, nor has it been commercially proven, so in that sense it is not yet available to BASF as a replacement.

4.3.6.5. Hazard and risk of Alternative 6 No particular additional hazards compared to the existing process have been identified. Clearly the (small) risk associated with exposure to EDC would be eliminated so the process is likely to represent a marginally lower risk in terms of the authorisation process.

4.3.6.6. Conclusions on Alternative 6 Pressure swing distillation represents a potential alternative route to trioxane production and purification that does not involve the use of an extraction solvent such as EDC. It is theoretically technically feasible, but significant issues were identified when the technology was scaled up to a mini-plant level. In order to make this technology suitable for BASF, further intensive process design would be required in order to eliminate the issue of formic acid contamination of the trioxane. A full-scale plant would need to be constructed, and the resultant POM tested by BASF and customers for suitability.

The implementation of this process is therefore considered to be economically not feasible. It is also not currently available, or technically feasible at commercial scale.

4.4 The most likely non-use scenario

4.4.1 Summary of conclusions on alternatives The preceding sections outlined the results of BASF’s investigation into over 7,000 potential alternative solvents (with more detailed conclusions provided on the most technically promising identified through the screening process) and two types of alternative technology. The table below provides a simplified summary of the conclusions on these alternatives. Further information on the overall process is provided in Appendix B.

Table 8 Summary of conclusions on alternatives

Technical Economic Reduction in Availability feasibility feasibility overall risk Alternative solvents Benzene Yes Possibly No Yes Dichloromethane No Possibly Possibly Yes N-butyl methyl ether Possibly No Possibly No Isoflurane Possibly No No No Alternative technologies Crystallisation Possibly No Yes Possibly Pressure swing distillation Possibly No Yes Possibly

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Overall, the conclusion is that none of the identified, short-listed alternatives are suitable and available for BASF. It is recognised that two of these – benzene and crystallisation – are in use by competitors in the EU (crystallisation) and elsewhere (benzene). However, as demonstrated above, they are not suitable for BASF in Europe. Benzene is unlikely to lead to a reduction in health risk and crystallisation is protected by patents, would require an economically unfeasible period to implement and produces a trioxane product which may not be technically suitable in BASF’s polymerisation plant10.

Nonetheless, it may be possible, with further research and development, to identify and develop a suitable alternative solvent or technique. The following sections outline the key steps that would need to be taken in order to implement an alternative if authorisation is not to be granted.

4.4.2 Implications of switching to an alternative

4.4.2.1 Overview As outlined above, BASF has undertaken significant research into identifying potential alternative solvents for trioxane extraction. However, to date no suitable alternative has been identified. BASF continues to search for alternatives and it is possible that, at some point in the future, an alternative solvent will be identified; however, it is unlikely that this could be used in the existing plant. Therefore, even if an alternative solvent is found, it would not be possible to simply implement the alternative immediately.

In addition to alternative solvents, two potential alternative techniques for trioxane production have been investigated by BASF: crystallisation and pressure swing distillation. Neither of these could be implemented in BASF’s existing plant and both would require the construction of a new plant, as well as significant process and product development time for implementation.

4.4.2.2 Timescale to switch to an alternative process BASF has mapped out the steps that would need to be taken to implement an alternative production process (crystallisation), along with the associated timescales, in the table below. This includes timescales if BASF were to (a) develop the crystallisation technology itself, and (b) buy a licence to use the technology from a competitor.

Table 9 Main steps to implement an alternative production process

No Step Duration Duration to to buy develop (months) (months) 1a Design and develop production process (including construction and 60 operation of pilot plant) 1b Buy technology 24 2 Conceptual engineering / license to operate 12 12 3 Detail engineering and construction 36 30 4 Start-up / commissioning 6 6 5 Customer approval 24 24 Total (months) 138 96 Total (years) 11.5 8

The above estimates take into account BASF’s experiences with processes and plants of similar size and complexity to that needed for a new trioxane process. BASF has recently migrated the work-up of part of the production of another big monomer, acrylic acid, into crystallisation. The estimates of timescales above are mainly based on experience with that plant. They were further developed for this authorisation application, by a team of

10 Furthermore, the economic and technical suitability of this process is questioned as the competitor using this technology in Europe is currently developing a new plant in Saudi Arabia, which it is understood will use benzene technology.

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BASF experts based on experience with many BASF plants across the Ludwigshafen site, over many years. In particular, these reflect the timescales required for another crystallisation plant (of a different type and related to a different product line) on BASF’s site in Ludwigshafen. Specifically, the above relate to construction of a plant with 60,000t annual trioxane capacity.

4.4.2.3 Timescale to switch to an alternative solvent As set out previously, BASF has not identified an alternative solvent that could be used in the Ultraform® plant. However, if BASF were to adopt this route, the associated timescales have been estimated as shown below.

BASF has mapped out the steps that would need to be taken to implement an alternative solvent, along with the associated timescales, in the table below.

Table 10 Main steps to implement a (hypothetical) alternative solvent

No Step Duration (months) 1 Design and develop production process 12-24 2 Construct alternative pilot plant and produce first product 30 3 Ensure customer acceptance of product 18 4 Engineering for full-scale plant 18 5 Construction of new plant 30 6 Down time / adaptations in upstream or downstream units (in parallel) 5 7 Test runs 3 8 Start full-scale production 2 9 Time to reach full-scale production (depending on sufficient demand) 8 Total 121 -131 months (~ 10 - 12 years)

In addition to the time in the above table, there would be further time associated with R&D to identify and select the alternative. Given that there is not yet a sufficiently promising candidate substance, this could be a substantial time, but the exact timescale cannot be estimated.

Of course if a true ‘drop in’ alternative were to be identified, several of these steps would not be required i.e. a new full-scale plant would not be required. The time needed might therefore be less, but it would still be significant11. However, it should be reiterated that BASF has not found any promising alternative to date despite detailed investigations.

Since there is no alternative solvent available, and even if there were, the timescales and cost would be at least as great as those to implement an alternative process, use of an alternative solvent is clearly not feasible.

4.4.2.3 Conclusions on potential alternatives Based on the above, taking into account the sunset date of 22 November 2017, if BASF is not granted an authorisation, use of an alternative solvent or technique is not a viable option. The existing trioxane monomer plant would therefore become redundant. Even if an alternative were identified, for possible implementation after the sunset date, there would be a lengthy downtime period before any new plant could be made commercially operational. Given that BASF would effectively be unable to produce POM for several years during this downtime period, BASF would lose market share to competitors. BASF would not have a realistic expectation of regaining

11 For example, 66 months (5.5 years) for steps 1, 4, 7, 8, 9 and 10.

Public Version 32 ANALYSIS OF ALTERNATIVES and SOCIO-ECONOMIC ANALYSIS this market share, making this option untenable. Added to this, the costs associated with adopting this option (around [Claim #2] investment cost12) are considered to be prohibitive, as described above.

Furthermore, as the plant at Ludwigshafen is fully integrated – from manufacture of methanol right through to production of POM – there would be significant knock-on implications for the other related plants on the site. In theory, one option would be for BASF to stop trioxane production and simply buy the substance from external suppliers, for use in the polymerisation plant. However, this is not possible: all POM plants globally have their own monomer production because the polymerisation process results in formation of trioxane monomer as well as well as formaldehyde (trioxane is a trimer of formaldehyde), and these need to be recycled back into the trioxane process. Therefore, the whole POM production plant would be rendered redundant, and an alternative market would need to be found for some of BASF’s methanol/formaldehyde production.

4.4.4 Overall conclusions on the non-use scenario Taking into account the above, BASF has reviewed the options for continuation of this line of business. In the event that BASF is not granted an authorisation for continued use, the senior management have concluded that the non-use scenario would be closure of the trioxane production plant, and along with it the POM production plant. This has been confirmed by the senior vice president of the regional business unit ‘Performance Materials Europe’, [Claim #6]

12 This cost estimate has been derived from recent experience where BASF has migrated the work-up of part of the production of another big monomer, acrylic acid, into crystallisation. The expertise for the cost is based on data for the year 2013, for a plant with capacity of 60,000 tonnes per year (using an internal expert benchmark study). The cost is comprised of: Acidic trimerisation and initial distillation of [Claim #2]; workup (breaking the azeotrope via crystallisation of [Claim #2]; distillation equipment at [Claim #2], giving a total investment cost for a new trioxane plant of [Claim #2].

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5. IMPACTS OF GRANTING AUTHORISATION

5.1 Economic impacts

5.1.1 Scope of the analysis As per ECHA’s combined format, this section provides a description of the economic impacts of not granting an authorisation for continued use of EDC by comparing the “applied for use” and the “non-use” scenario. While some information was provided in the preceding sections on “economic feasibility” and “availability”, this section provides a more detailed analysis, including broader socioeconomic considerations.

Where practicable, a quantitative assessment of the economic impacts for BASF and the supply chain is presented. Possible costs and savings to other supply chains if an authorisation is not granted are considered.

A discussion is also provided on the significance of the impacts as well as the certainty and confidence in the description and quantification of economic impacts.

For indicative purposes, an assessment period of 12 years has been used when estimating costs associated with the restriction, which is based on the upper end of the typical range of authorisation periods expected to be granted by ECHA13. This is in order to ensure consistency between estimates, particularly when estimating annualised costs. A discount rate of 4% has been used.

5.1.2 Supply/value chain and markets affected The figure below provides a simple representation of the supply and value chain that would be directly affected by a non-granted authorisation.

13 As demonstrated later in this document, BASF believes that the authorisation application fulfils the criteria for granting of an authorisation with a long review period.

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Figure 5 Simple representation of trioxane and POM supply/value chain

BASF Ludwigshafen

Precursor manufacture (methanol, formaldehyde)

Trioxane monomer plant

POM production plant

POM processors

Transportation Industrial Consumer Construction (30%) (32%) (31%) (7%)

● Fuel systems ● Irrigation systems ● Zippers ● Plumbing (fixtures, fittings, ● Seat belt buckles / retractors (commercial, home, garden, ● Buckles float valves) ● Gears farm) ● Clips (sealing) ● Solar panels ● Head-rest parts ● Pumps ● Consumer electronics ● Window and blind fittings ● Wiper motors ● Extrusion products (rod, ● Small and large appliances ● Gears ● Clips and fasteners sheet, tubing) ● Medical products (inhalers, ● Fasteners ● Steering wheel buffers ● Electrical devices (industrial injectors) ● Water, electricity and gas ● Car locks and commercial) ● Computer and office meters ● Door handles ● Gears accessories (printers, copiers, ● Switches ● Instrumentation keys, etc.) ● Interior controls ● Controls ● Toys ● Window and seat adjustments ● Conveyor systems (belts and ● Pens ● Speaker grills chains) ● Ski accessories ● Etc. ● Etc ● Lawn and gardening equipment ● Bike carriers ● Roof racks ● Furniture accessories

As can be seen from the above, the end products in which POM is used are hugely varied and are in use throughout society, in numerous products that people use day-to-day. Although these products do not contain EDC, their existence depends on the production of high purity trioxane, which is produced by BASF using EDC. In addition to economic impacts on BASF, therefore, this report also considers implications for the processors and end-users of the POM.

5.1.3 Direct economic impacts for BASF The estimates provided below assume that BASF, in the long term, will try to continue producing and supplying POM in the EU, for the EU and international markets. The impacts on BASF are associated with closure of the existing monomer plant (and POM plant) with associated revenues being foregone. As demonstrated earlier, if an authorisation is not granted, it would not be commercially viable for BASF to introduce a new trioxane production/purification plant after the sunset date to re-enter the market.

With the closure of the existing trioxane and POM plant, BASF would not be able to realise the (remaining) value of the plant equipment as it is highly specialised and dedicated to production of trioxane using the EDC-based Public Version 35 ANALYSIS OF ALTERNATIVES and SOCIO-ECONOMIC ANALYSIS process. In line with ECHA’s guidance on SEA, one method of estimating the residual value of capital equipment is through estimating the net revenues that would be foregone. In the case of the trioxane/POM production plant, the net revenues foregone are approximately:

 [Claim #1] revenues per year, based on production of approximately [Claim #1] (and an approximately equivalent amount of POM), based on sales in the 5 years to 201414. Based on an ‘impact realisation’ period of 12 years from the sunset date and using a discount rate of 4%, this translates to a present value of around [Claim #1] 15.  In terms of profits foregone, the loss of EBITDA associated with this loss of revenues is estimated at between around [Claim #1], or around [Claim #1] present value over the same period16.

If, in the longer term, BASF decides to continue its production of POM polymer, BASF would also incur costs associated with construction of a new trioxane production plant. This would only enable production of POM several years after the sunset date, during which time the above estimates of revenue and profits foregone would be incurred.

As detailed previously, this is expected to take several years and the cost is estimated at around €140 million Euros. Expressed in annualised terms, this equates to a cost of €14.9 million per year17.

5.1.4 Economic impacts for downstream users (POM processors) BASF only manufactures POM in Ludwigshafen in Germany. Details of the production capacity at Ludwigshafen, along with the sizes of the (overall) markets for POM are shown in the figure below.

Figure 6 BASF production and global markets for POM [Claim #1].

Production capacity is [Claim #1]) and actual production was [Claim #1] in 2013. Dark circles represent BASF sales while light circles represent total market.

In 2013, BASF sold approximately [Claim #1] of POM in Europe. As detailed earlier, the global market for POM is currently experiencing high levels of oversupply, and this is expected to continue in the future, particularly with Asian capacity expected to continue increasing, even within the context of a global demand expected to increase until 2020 and beyond. This is explored further below.

In the event that an authorisation is not granted, of the sales into Europe, BASF estimates that two thirds will most likely be substituted with standard grades from Asian POM producers (typically produced using benzene as the extraction solvent). The remaining third of BASF sales is to the transportation sector and/or specialty applications in other industry sectors, which is expected to be taken up primarily by supply from European competitors, due to the quality requirements, which will also require requalification by end-users (see below). Some of this demand though would also be taken up by Asian suppliers.

Overall, the main impacts for POM processors are expected to relate to the costs associated with sourcing an alternative supply of POM, testing products in processing equipment (e.g. injection moulded products) and ensuring approval of the processed products by the end users. These costs are likely to be mainly related to staff time and also some product wastage related to any unsuccessful tests. It has not been possible to further quantify these costs.

14 This equates to an average sales value of just over [Claim #1]). This compares to AMI (2013) estimate of €2900 per tonne. Prices have decreased in recent years e.g. from €3110 per tonne for natural POM and €3380 per tonne for carbon reinforced (SRI, 2011).

15 Based on forecast net sales [Claim #1] per year over 2015-18, with revenues calculated between 2017 (sunset date) and 2029.

16 This is based on forecast EBITDA for 2015-18 of [Claim #1] per year. Present value calculated between 2017 (sunset date) and 2029 assuming a discount rate of 4%.

17 Assuming that costs could be depreciated over a period of 12 years (for convenience) and using the standard discount rate of 4%.

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5.1.5 Economic impacts for end-users As highlighted above, the end uses for POM broadly fall into four categories: transportation, industrial, consumer and construction. Key properties of POM polymers are:

 High rigidity and strength  Low friction  Good elastic recovery  Chemical resistance  Good weathering properties (for C-POM, which BASF produces)

They are particularly suitable for gears and components performing a spring-type function, as well as in domestic appliances and in plumbing. Over 90% is processed using injection moulding (AMI, 2013).

Due to the current oversupply in the global POM market, it is not expected that there would be a shortage in supply of POM-based components, because there would not be a shortage of POM itself on the market. The table below illustrates world capacity, production, trade and consumption for polyacetal resins in 2013.

Public Version 37 Table 11 Global supply and demand for POM (IHS Chemical, 2014)

The greatest European demand for POM is in Germany (36%), followed by Italy (12%) and France (11%) (AMI, 2013). Growth in demand in Europe is forecast to increase by 1.7% between 2012 and 2020 compared to average global growth of 3.3% (Ceresena, 2013). These figures are in reasonable agreement with those above from IHS (2014), where the expected growth rate in Western Europe is lower than Central Europe.

However, it is possible that there would be greater competition from non-EU suppliers of POM-based components across various sectors. It becomes less likely that supply chains for POM-based products will continue to be based in the EU, if the primary source of the POM moves to Asia (for some companies). It is possible therefore that there could be a further loss of economic activity (in addition to BASF’s POM production) from Europe, further down the value chain. This issue has not been investigated in detail as the case for the SEA is considered to be clear without expending significant effort quantifying this impact (i.e. it is not necessary for a proportionate analysis).

A further impact for downstream users would be the need to requalify products. POM is used in various safety- critical components, particularly in the automotive sector (such as seat belt stop mechanisms). Customers would need to undertake various strength and reliability tests across numerous different components in order to ensure that the products made with the alternative POM source can perform comparably to those using BASF’s POM.

BASF has made a provisional estimate of the potential cost of this requalification in the automotive industry of [Claim #3]. This is likely to be a one-off cost, borne over the course of approximately a year. This estimate was derived as follows:

As most of the POM applications in transportation are safety-critical, long term uses, extensive long term testing is required to prove the feasibility of an alternative material for a given use. BASF has made an approximate estimate of the potential cost impact of qualifying a new material, taking into account the specific requirements ANALYSIS OF ALTERNATIVES and SOCIO-ECONOMIC ANALYSIS and criticality of the main applications. Likewise, POM parts in automotive interiors are required to pass stringent formaldehyde emission tests as part of their validation/homologation.

From the total sales in transportation (excluding distribution sales, where detailed allocation to applications is not possible) the following main application segments can be identified:

Table 12 Key applications of POM in transportation applications

Application Share No of key Safety Emission accounts critical? critical? Fuel parts / Fuel system [Claim #1]. [Claim #1]. Y N Auto Interior Parts [Claim #1]. [Claim #1]. Y/N Y Control units, motors & actuators, E&E [Claim #1]. [Claim #1]. Y/N Y/N others Auto Powertrain [Claim #1]. [Claim #1]. Y/N N Seats & Belts [Claim #1]. [Claim #1]. Y Y

Fuel parts include fuel pumps, fuel filters and fuel tank units (fuel gauge, located within the tank). Key requirements are lifetime functionality with no degradation over time in constant contact with any variety of fuel (gasoline, ethanol, diesel, biodiesel and their mixtures; involving other chemical additives). Typical test patterns will involve storing the test specimen as well as actual functional parts in various standard fuels in autoclaves, at standard or elevated temperatures, followed by thorough mechanical testing. Cost for these test runs are estimated at around [Claim #1], or [Claim #1] in total.

Auto interior parts consist of decorative parts (e.g. loudspeaker grilles), a large variety of clips, fasteners and fixtures, and functional parts in window mechanisms, switches, etc. These parts are typically less safety-critical. However their formaldehyde emission is critical and will need to be tested. BASF have [Claim #1] relevant key accounts and estimate validation costs at approximately [Claim #1] each, or [Claim #1] in total.

Seats and belts: [Claim #1] of BASF’s transportation sales is in this category. Highly specified, impact modified grades are used for the latch mechanism in safety belts and other passenger restraint devices; they require lifetime functionality even after long term heat, aging and at high or low ambient temperatures. Cost for testing is estimated at [Claim #3] at the [Claim #3] larger Key Accounts, or [Claim #3] in total.

Under Powertrain, various small parts are produced at [Claim #3] Key Accounts. BASF estimates specific part testing would cost around [Claim #3].

Electrical control units, motors and actuators, E&E is a group of functional mechanical parts, including gears, in electromechanical assemblies. As many small parts are involved, the validation is expected to be carried out on the actual parts. BASF has [Claim #3] customer groups, each delivering products to several OEMs. BASF estimates the cost of requalification at a minimum of [Claim #3].

The above estimates total approximately [Claim #3] cost at the affected Key Accounts. However some of the OEMs (as end customers) as well as the smaller accounts not reflected in the above figures, will require additional validation tests. BASF assumes a 30% to 60% additional cost associated with this, so the total cost in the value chain may be in the range between [Claim #3].

The figures given above are rough estimates. However, they give an indication of the likely scale of the costs, for just one of the main areas of application of POM.

5.1.6 Significance of impacts and uncertainties Overall, a non-granted authorisation would have significant impacts for BASF in terms of the loss of the residual value of current equipment and loss of revenues from POM sales. There would also be substantial investment costs associated with construction of a new trioxane production plant if BASF wishes to re-enter the POM market several years after the sunset date. The annualised costs (estimated at [Claim #1]), are substantially higher than

Public Version 39 ANALYSIS OF ALTERNATIVES and SOCIO-ECONOMIC ANALYSIS the estimated EBITDA value for the current production plant ([Claim #1]). Moreover, because of the downtime in production, taking into account the market characteristics described above, BASF would likely irrecoverably lose market share if the plant were to be constructed in Europe.

In addition to effects on BASF, there could also be significant negative impacts down the supply chain, particularly in terms of the need for product requalification (e.g. costs of requalification were estimated as [Claim #1] for the automotive industry), but also in terms of POM processors needing to find alternative sources of POM, which are likely to be predominantly based in Asia.

Clearly the forecast estimates of revenues and EBITDA are subject to uncertainty, as are the costs associated with construction of a new plant. However, both are comparable to historical experience at BASF’s Ludwigshafen site and in BASF’s view represent a reasonable estimate based on all known factors.

5.2 Human health and environmental impacts A non-granted authorisation would eliminate the risk to workers at BASF’s plant in Ludwigshafen associated with exposure to EDC, as well as the risk for humans exposed via the environment through the (very small, <1kg/yr) releases through the plant incinerator.

As indicated previously in this report, the monetised estimate of the excess cancer risk avoided (i.e. the difference between the continued use and non-use scenarios) is very small, but has been quantified as shown in the table below. The risks to workers are valued at a maximum of around €1,200, related to exposure over 40 years and assuming a worst case in terms of exposure levels. An annualised estimate of this cost, with a discount rate of 4% and an annual uplift of 2%18 would be of the order of €29/yr. The more ‘realistic’ case estimates of these figures are €206 for the total plant risk over 40 years’ exposure and €5/yr as an annualised value. In reality, BASF believes that the impacts are even lower than this, as these values include dermal exposure, which has been demonstrated to be negligible in the CSR.

Table 13 Monetary value estimates of human health impacts

Worst case Realistic case Number of workers exposed 35 6.7 Worker excess cancer risk due to inhalation exposure €1,050 (€25/yr) €179 (€4.3/yr) Worker excess cancer risk due to dermal exposure €158 (€3.8/yr) €27 (€0.6/yr) Worker excess cancer risk (inhalation and dermal) €1,208 (€29/yr) €206 (€4.9/yr) Impacts for humans exposed via the environment €13 (€0.3/yr) €13 (€0.3/yr) Total excluding dermal exposure €1,063 (€26/yr) €192 (€4.6/yr) Total including dermal exposure €1,221 (€29/yr) €219 (€5.3/yr) Values in parentheses are annualised costs.

There could also be other human health impacts if an alternative to BASF’s POM is used. If insufficient testing is undertaken of final products in safety-critical equipment, there is in theory the potential for more frequent equipment failure and hence potential safety implications. However, it is assumed that companies’ testing and approval processes are sufficient to eliminate any such increase in failures. 5.3 Social impacts The main social impact expected with a non-granted authorisation would be a loss of employment at BASF of staff employed in POM production. BASF employs [Claim #2] in its Ultraform® business in Europe ([Claim #2]),

18 It is common practice in some analyses to include an uplift factor of e.g. 2% per year to reflect society’s increased value attached to health over time. Likewise no decline in the level of the discount rate is applied despite the long time period for the assessment over 40 years. The annualised value is given by dividing the total value by 40 to give the estimate for exposure in 2015, with the 2% annual uplift and 4% discount applied to give the value in 2017 (the sunset date)

Public Version 40 ANALYSIS OF ALTERNATIVES and SOCIO-ECONOMIC ANALYSIS with a further [Claim #2] related to sales and marketing. While some of the individuals whose jobs would be lost may be able to find alternative employment within BASF, there would be a net reduction in numbers of people employed, estimated at the total of [Claim #2]).

It is possible that some of these employment effects could be offset through increased production (and hence increased need for employment) at BASF’s European competitors so that the overall social benefit may over time be reduced, although this may still involve periods of unemployment and associated costs. However, BASF understands that these companies are also operating close to capacity, and the continuation of POM supply to Europe would most likely be through Asian suppliers. 5.4 Wider economic impacts Based on the preceding analysis the main wider economic impacts would be:

 A loss of economic activity associated with POM currently being supplied by BASF being replaced by production from outside the EU, as Asian suppliers are expected to replace the majority of the POM supply in the event that BASF can no longer supply the product.  Reduced competition in the European POM production market (from the current four main producers to three).  Reduced tax and other revenues in Europe associated with producing and selling POM in Europe, and associated with employing staff in production, sales and marketing.  An acceleration of existing quality improvement from non EU manufacturers of POM associated with investment outside of the EU from companies that are currently based within the EU, which may over time take increased market share from the remaining competitors.

In addition, a non-granted authorisation would restrict the ability of BASF’s Ludwigshafen plant to act as a truly integrated plant, as a key part of the production on site would be lost. 5.5 Distributional impacts The impacts of a non-granted authorisation would be borne by the following actors in the value chain:

 There would be a reduced cancer risk for workers at BASF's Ludwigshafen site, though the level of this reduction would be negligible.  There would be no health benefits for other actors in the supply chain, as EDC is only present at negligible amounts in the POM polymer sold by BASF.  BASF itself would incur loss of profits for several years, estimated at between [Claim #1] per year, expressed as EBITDA.  In the longer term, BASF would also incur costs associated with construction of a new plant using alternative technology (coming into operation several years after the sunset date), equivalent to around €15 million per year, over 12 years.  BASF's customers would face requalification costs through using an alternative source of POM (i.e. sourcing from BASF''s competitors). The annualised cost for the transportation sector alone is estimated at [Claim #3], and other sectors would also be affected (but effects to these have not been quantified).

5.6 Uncertainty analysis The key uncertainties in the analysis are described below.

In terms of direct impacts to BASF, the estimates of future revenues and EBITDA foregone are based on historical values and BASF's forecasts. These could be higher or lower, but are not expected to vary substantially.

The estimates of avoided cancer risks associated with a non-granted authorisation are considered to be over- estimates (e.g. based on assumed inhalation exposure at the analytical detection limit, whereas actual exposure is below this limit). The values quoted in this report include risks related to dermal exposure, and are thus conservative, given that the CSR demonstrates that dermal exposure is likely to be negligible.

The estimated costs to downstream customers of POM in the automotive sector are based on BASF's estimates of requalification costs, derived based on BASF's knowledge of and relationship with the sector. They have not been Public Version 41 ANALYSIS OF ALTERNATIVES and SOCIO-ECONOMIC ANALYSIS verified with the automotive sector. However the overall costs are likely to be much higher, given that there are many other end-user sectors.

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6. CONCLUSIONS

6.1 Comparison of the benefits and risk The remaining or excess cancer risk to individual workers’ health of continued use of EDC at BASF’s facility in Ludwigshafen is estimated as a maximum of 6.9 x 10-6 based on exposure over 40 years (6.0 x 10-6 if dermal exposure is excluded). This is a maximum because it is based on actual measured exposure levels, but taking the limit of detection as the exposure level, as the actual exposure was below the detection limit of the equipment. The figure below shows how this exposure compares to the German risk-based concept for carcinogenic substances, which demonstrates that the risk to BASF’s workers at the Ultraform® plant is below both the tolerable risk threshold (4 in 100019) and the acceptable risk threshold (4 in 10,000, reducing to 4 in 100,000 by 2018 at the latest).

Figure 7 Comparison of BASF Ultraform® plant risks with German risk-based concept for carcinogenic substances

Source: From BAUA (2013), with annotations.

Based on the above, it becomes obvious that the operational conditions and risk management measures in place are appropriate and effective in limiting the risks from EDC.

Across the entire workforce, the excess cancer risk is estimated as 2.3 x 10-4 based on a 40 years working lifetime of exposure, assuming a worst case in terms of number of people exposed and duration of exposure. Based on

19 Workers exposed throughout their working life.

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ECHA’s willingness to pay estimates for avoiding cancer, this translates to an estimated €1,155 for the full 40 year exposure. To aid comparison with the socio-economic benefits of authorisation (avoided costs) this is converted to an annualised value of €28 per year.

When applying the realistic estimate of numbers of workers exposed and duration of exposure, the excess cancer risk comes down to 3.9 x 10-5 across the workforce of the Ultraform® plant. This translates to an estimated €197 for the full 40 year exposure, or €9 per year as shown in the table below.

Table 14 Summary of avoided excess cancer risk and monetary valuation

Worst case Realistic case Individual excess cancer risk for workers (40 years) 6.9 x 10-6 6.0 x 10-6 Ultraform® plant excess cancer risk (40 years) 2.4 x 10-4 3.6 x 10-5 Excess cancer risk for humans exposed via environment 3.1 x 10-9 (individual) 3.1 x 10-9 (individual) 2.7 x 10-6 (1 km2 2.7 x 10-6 (1 km2 population) population) Monetary value of total excess cancer risk (40 years) €1,221 €192 Annualised value of total excess cancer risk €29 €4.6 Notes: For the worst case, individual excess cancer risk is based on measured data for inhalation exposure (worst case as values are below the detection limit, and exposure at the detection limit was assumed) and modelled data for dermal exposure as set out in the CSR. Plant excess cancer risk is calculated assuming all 35 employees are exposed continuously all of the working year for 40 years. In the realistic case, occupancy of relevant areas where exposure can occur is taken into account, as well as the duration of exposure for workers only involved in maintenance, as set out in the CSR (this reduces the equivalent FTE workers exposed to 6.7. Dermal exposure is not included in the realistic case estimate. Monetary value is based on a WTP value to avoid death from cancer of €5 million based on ECHA’s recent study (Alberini A and Ščasný M (2014)). The annualised value of the plant excess cancer risk is given by dividing the total value by 40 to give the estimate for exposure in 2015, with the 2% annual uplift and 4% discount applied to give the value in 2017 (the sunset date). Note that numbers have been rounded.

A granted authorisation would avoid a significant loss of revenue for BASF, with total revenue loss estimated as around [Claim #1], and EBIT loss of around [Claim #1].

The above relates to costs incurred for several years after the sunset date. If BASF were to continue to take part in the POM market in the longer term, construction of a new plant (using an alternative technology) would be required. This could only become operational several years (around 10-12 years) after the sunset date. The cost needed for this plant is estimated at around [Claim #2], expressed as an annualised cost over 12 years. Note that these costs are not included in the overall conclusions below.

A granted authorisation would also avoid costs to downstream users, most notably to companies needing to requalify their POM products in sectors such as transportation. These costs are estimated by BASF to be in the order of [Claim #1] for the transportation sector alone. Again expressed as an annual cost over 12 years, these equate to [Claim #1] per year.

A granted authorisation would furthermore avoid the loss of around [Claim #3] within BASF. It would avoid a reduction in competition within the EU POM market (limiting the number of EU producers to 3, of which only 2 would be C-POM producers), and avoid reducing the competitiveness of the EU manufacturers in a global context.

In the table below a summary of the quantified benefits and costs of a non-granted authorisation, expressed on an annual basis is provided, illustrating clearly that the costs of not granting authorisation outweigh the benefits by

Public Version 44 ANALYSIS OF ALTERNATIVES and SOCIO-ECONOMIC ANALYSIS over 5 orders of magnitude under the worst case exposure scenario20. Under the more realistic case exposure scenario, the costs outweigh the benefits by over 6 orders of magnitude.

Table 15 Summary of quantified benefits and costs (annualised values)

Benefits Costs Avoided cancer risk from EDC exposure €29 (worst case) €4.6 (realistic case) Loss of profits (expressed as EBITDA) [Claim #1] ** Construction of replacement plant after SD [Claim #1/2] Downstream user requalification costs * [Claim #3] Total €29 (worst case) €20.3 – 26.2 million €4.6 (realistic case) Ratio of benefits to costs of not granting Between 1.1 x 10-6 : 1 and 1.4 x 10-6 : 1 authorisation - worst case exposure (costs outweigh benefits by 690,000 to 890,000 times) Ratio of benefits to costs of not granting Between 1.8 x 10-7 : 1 and 2.3 x 10-7 : 1 authorisation - realistic case exposure (costs outweigh benefits by 4,400,000 to 5,700,000 times) * Transportation sector only ** [Claim #1]. Figures have been rounded.

6.2 Information for the length of the review period ECHA typically considers a number of standard durations for the review period: a normal review period of 7 years, a short review period of e.g. 4 years and a long review period of 12 years.

BASF has undertaken extensive research into possible alternative solvents, and to date has not identified any with sufficient prospects to suggest that they could be used as alternatives to EDC in the foreseeable future. Even if an alternative solvent were identified, it is estimated that up to 14 years would be needed to implement the new process with that solvent (the existing plant is unlikely to be suitable for an alternative solvent).

The technically more promising option would be to eliminate the need for a solvent and construct a new plant using an alternative technology. It is estimated that this would take around 12 years to implement. However, it must be noted that BASF does not intend to pursue this route, given the significant financial costs involved, and the likely loss of market position between the sunset date and full commercialisation.

The above suggests the minimum review period in this case should be at the high end of ECHA’s guideline values i.e. 12 years. This would be consistent with ECHA’s guidance which states that such a review period is applicable where a number of conditions are fulfilled. This is shown in the table below.

20 This is a minimum because, for example, a worst case was assumed with regard to exposure levels for workers, and because not all costs for downstream user requalification have been quantified, nor have effects related to loss of revenues from other parts of the integrated site at Ludwigshafen in Germany.

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Table 16 Demonstration that BASF Ultraform® case fulfils case for long review period

Criterion Situation for BASF The applicant’s investment cycle is demonstrably Investment cycle is certainly very long. very long (i.e. the production is capital intensive) There is no end-of-life timescale for the trioxane plant. making it technically and economically meaningful Although the existing trioxane plant is relatively old, it to substitute only when a major investment or undergoes planned maintenance every year which refurbishment takes place. involves the replacement of various components, in order to ensure that the continuously-rising demand for trioxane is met. In particular, the extraction columns were replaced for higher throughput towers in 2008 (investment about €4 million). The associated costs are included in financial forecasts and operational planning. There is no wholesale end of life foreseen for the plant. This approach has been implemented by BASF since the start of the plant’s operation. On this basis, the plant has essentially the same business value now as when it was built. This is not at all unusual for plants running with a very particular solvent used in a highly specialised use or application Estimated [Claim #2] to construct a new plant to avoid use of EDC. The costs of using the alternatives are very high BASF has investigated alternatives for several years. and very unlikely to change in the next decade as Alternatives on the market are not technically feasible, technical progress (as demonstrated in the economically feasible or even available to BASF. There application) is unlikely to bring any change. is no expected change to this situation in the coming years. The applicant can demonstrate that research and BASF has a strong record on R&D and has investigated development efforts already made, or just started, alternatives for several years. did not lead to the development of an alternative Even if an alternative were identified, it would take over that could be available within the normal review 10 years to implement that alternative, making the total period. transition time over 12 years. The possible alternatives would require specific This is not the case for BASF’s Ultraform® plant. legislative measures under the relevant legislative area in order to ensure safety of use (including acquiring the necessary certificates for using the alternative). The remaining risks are low and the socio- The remaining risks are demonstrably low by economic benefits are high, and there is clear comparison with relevant risk tolerability criteria and evidence that this situation is not likely to change when expressed in monetary terms. Use and exposure of in the next decade. EDC is unlikely to change in the future. The socio- economic benefits of POM use to BASF and to EU society are expected to persist in the next decade and longer. Based on: Setting the review period when RAC and SEAC give opinions on an application for authorisation, SEAC/20/2013/03, 13 September 2013.

Four out of these five criteria are fulfilled in this case, making a compelling case for a review period of at least 12 years, if not longer.

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6.3 Substitution effort taken by the applicant if an authorisation is granted If an authorisation is not granted, BASF will be forced to stop trioxane and hence POM production at Ludwigshafen in Germany.

If the authorisation is granted, BASF will continue to undertake research and development efforts into alternative solvents that could be used in the existing trioxane plant. This has always been part of BASF’s R&D activities as has been demonstrated in the analysis of alternatives.

BASF will also continue to consider the commercial viability of implementing an alternative technique (i.e. crystallisation) as a possible alternative process in line with BASF’s usual investment cycles. This could include developing BASF’s own process or obtaining a licence from a competitor. However, based on all activities already undertaken in this field (e.g. €8 million investment over several years in one of the potential alternative technologies) these are long-term options which could not be implemented any time soon after the sunset date for EDC.

BASF also pursue other strategic options to retain this important part of BASF’s business.

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7. REFERENCES

Alberini A and Ščasný M (2014): Stated-preference study to examine the economic value of benefits of avoiding selected adverse human health outcomes due to exposure to chemicals in the European Union, Service contract for the European Chemicals Agency No. ECHA/2011/123, FD7. Final Report Part III: Carcinogens, September 2014.

AMI (2013): 2013 European Plastics Industry Report, AMI Plastics.

BAUA (2013): The risk-based concept for carcinogenic substances developed by the Committee for Hazardous Substances - From limit-value orientation to an action-oriented approach.

Ceresena (2013): Market study – engineering plastics (chapter 4.5), September 2013.

ECHA (2015): Application for authorisation: establishing a reference dose-response relationship for carcinogenicity of 1,2-dichloroethane, RAC/33/2015/09 Rev1 Final, 5 June 2015.

European Commission (2000): Recommended interim values for the value of preventing a fatality in DG Environment cost benefit analysis.

Grützner T, Lang N, Siegert M, Ströfer E and Hasse H (2006): Development of a new distillation based process for trioxane production, IChemE symposium series no 152.

ICIS News (2010): Celanese-SABIC venture to build POM facility in Saudi Arabia.

ICIS Pricing (2015): Prices for ethylene dichloride in Western Europe and methylene chloride in Europe in 2014.

IHS Chemical (2014): Chemical economics handbook – polyacetal resins, July 2014.

IOM, AMEC and Imperial (2011): Health, socio-economic and environmental aspects of possible amendment to the EU Directive on the protection of workers from the risks related to exposure to carcinogens and mutagens at work, May 2011.

NHS (2015): Isoflurane (Isoflurane volatile liquid), http://www.nhs.uk/Medicine- Guides/Pages/MedicineOverview.aspx?condition=Anaesthesia&medicine=Isoflurane&preparationIsoflurane%2 0volatile%20liquid.

SRI (2011): Polyacetal resins, Chemical Economics Handbook, December 2011.

UK HSE (n.d.): Cost Benefit Analysis (CBA) checklist, http://www.hse.gov.uk/risk/theory/alarpcheck.htm, accessed 16 February 2015.

OECD (2012): Mortality Risk Valuation in Environment, Health and Transport Policies, Organisation for Economic Co-operation and Development.

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Annex – Justifications for Confidentiality Claims21

Blanked out item Page Justification for confidentiality reference number

Type#1 … Commercial information such as Sales, Turnover (Market Share), and Profitability: Considered sensitive and confidential as other players in the same value chain (competitors, suppliers, customers) could draw benefits (e.g. in price negotiations, strategic decisions). These figures are published only for BASF SE in total and for the top level Segments (e.g. in annual reports), but not for each product line. The potential harm for BASF would be a threat to business volume / market share, as well as profitability. Type #2 … Considered confidential as the estimated investment cost (as one-time cost or annualised figure) as well as number of plant employees would allow conclusions on BASF's present or potential future cost structure. If this information was known to customers and/or competitors, it could harm BASF’s position e.g. in price negotiations and threaten business volume / market share and profitability. Type #3 … Cost of qualification (or requalification) at main customers is considered CBI as it defines the market entry barrier for competitors. If this estimate was publicly known, business at our existing customers would be under threat. Type #4 This information is considered confidential technical information (trade secret that cannot be protected by patents). To avoid disclosure of technology know-how. Type #5 The process descripted in the permits manual has been developed by BASF within recent years. It is a BASF internal process with no relevance for the public comments. BASF invests money to keep it up- to-date and running (and did spend money to develop it). Disclosure of the process would mean a disclosure of an industrial secret. Because the process will be valid for many years, we request to keep it confidential for 10 years. Type #6 Appendix 3 Names and contact details of individuals (BASF and external staff) (in conf. have been redacted in the documents and in the appendices. The latter version) have not specifically been referenced with a number.

For all the above mentioned confidential business information, we claim that they be kept confidential for a period of ten years, i.e. until end of 2025. After this time, the information is assumed to no longer reflect the actual situation and its public knowledge will no longer harm BASF’s interests.

21 This annex will not be made publicly available as part of the broad information on uses package Public Version 49 ANALYSIS OF ALTERNATIVES and SOCIO-ECONOMIC ANALYSIS

APPENDCES

Appendix 1: Consultations

Appendix 2: List of 7200 substances screened as potential alternative solvents

Appendix 3: Report on approach to screening of potential alternative solvents

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Appendix 1: Consultations

No consultations with downstream users has been undertaken as there are no further downstream users of EDC.

Extensive consultation has been undertaken within BASF on the potential for introduction of alternative solvents or techniques, on the possible non-use scenarios, and on the economic and other implications of non-use of EDC.

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Appendix 2: List of 7200 substances screened as potential alternative solvents

Public Version 52 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 1333-74-0 WASSERSTOFF H2 2.02 0.00 7440-59-7 HELIUM He 4.00 [He] 74-82-8 METHAN CH4 16.04 C 7664-41-7 AMMONIAK H3N 17.03 N 7732-18-5 WASSER H2O 18.02 O 7664-39-3 FLUORWASSERSTOFFSAEURE HF 20.01 F 7440-01-9 NEON Ne 20.18 [Ne] 74-86-2 ETHIN C2H2 26.04 C#C 74-90-8 BLAUSAEURE CHN 27.03 C#N 7727-37-9 STICKSTOFF N2 28.01 N#N 630-08-0 KOHLENMONOXID CO 28.01 O=[C] 74-85-1 ETHEN C2H4 28.05 C=C 10102-43-9 STICKSTOFFOXID(NO) NO 30.01 [O+]#N 50-00-0 FORMALDEHYD CH2O 30.03 O=C 74-84-0 ETHAN C2H6 30.07 CC 74-89-5 METHANAMIN CH5N 31.06 CN 7782-44-7 SAUERSTOFF O2 32.00 O=O 67-56-1 METHANOL CH4O 32.04 CO 302-01-2 HYDRAZIN H4N2 32.05 NN 7803-62-5 SILAN H4Si 32.12 [SiH4] 7803-49-8 HYDROXYLAMIN H3NO 33.03 ON 7803-51-2 PHOSPHIN H3P 34.00 P 7722-84-1 WASSERSTOFFPEROXID(H2O2) H2O2 34.01 OO 593-53-3 METHYLFLUORID CH3F 34.03 FC 7783-06-4 SCHWEFELWASSERSTOFF(H2S) H2S 34.08 S 7647-01-0 CHLORWASSERSTOFFSAEURE HCl 36.46 Cl 7782-41-4 FLUOR F2 38.00 FF 7440-37-1 ARGON Ar 39.95 [Ar] 74-99-7 PROPIN C3H4 40.06 CC#C 463-49-0 1,2-PROPADIEN C3H4 40.06 C=C=C 75-05-8 ACETONITRIL C2H3N 41.05 CC#N 7216-97-9 dimethylborane C2H7B 41.89 CBC 463-51-4 ETHENON C2H2O 42.04 O=C=C 334-88-3 DIAZOMETHAN CH2N2 42.04 N#N=C 420-04-2 CYANAMID CH2N2 42.04 N#CN 115-07-1 PROPEN C3H6 42.08 CC=C 75-19-4 CYCLOPROPAN C3H6 42.08 C1CC1 75-13-8 ISOCYANSAEURE CHNO 43.02 O=C=N 420-05-3 CYANSAEURE CHNO 43.02 OC#N 7782-79-8 STICKSTOFFWASSERSTOFFSAEURE HN3 43.03 N#N=N 88333-02-2 (methyleneamino)-methylene C2H5N 43.07 CN=C 151-56-4 ETHYLENIMIN C2H5N 43.07 C1NC1 124-38-9 KOHLENDIOXID CO2 44.01 O=C=O 10024-97-2 DISTICKSTOFFMONOXID N2O 44.01 N#N=O 75-21-8 OXIRAN C2H4O 44.05 C1OC1 75-07-0 ACETALDEHYD C2H4O 44.05 CC=O 463-52-5 formamidine CH4N2 44.06 N=CN 74-98-6 PROPAN C3H8 44.10 CCC 1495-50-7 CYANOGENFLUORID((CN)F) CFN 45.02 FC#N 75-17-2 formamideoxime CH3NO 45.04 ON=C 75-12-7 FORMAMID CH3NO 45.04 O=CN 124-40-3 N-METHYLMETHANAMIN C2H7N 45.08 CNC 75-04-7 ETHANAMIN C2H7N 45.08 NCC 10102-44-0 STICKSTOFFOXID(NO2) NO2 46.01 0.00 64-18-6 AMEISENSAEURE CH2O2 46.03 OC=O 75-02-5 FLUORETHEN C2H3F 46.04 FC=C 64-17-5 ETHANOL C2H6O 46.07 OCC 115-10-6 DIMETHYLETHER C2H6O 46.07 COC 60-34-4 METHYLHYDRAZIN CH6N2 46.07 CNN 992-94-9 METHYLSILAN CH6Si 46.14 [SiH3]C 7782-77-6 SALPETRIGESAEURE HNO2 47.01 ON=O 67-62-9 METHOXYAMIN CH5NO 47.06 NOC

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CAS Name Sufo MW Smiles 593-77-1 N-HYDROXYMETHANAMIN CH5NO 47.06 ONC 10028-15-6 OZON O3 48.00 [O-][O+]=O 1493-02-3 FLUORMETHANAL CHFO 48.02 FC=O 3031-73-0 METHYLHYDROPEROXID CH4O2 48.04 OOC 353-36-6 ETHYLFLUORID C2H5F 48.06 FCC 74-93-1 METHANTHIOL CH4S 48.11 SC 7789-25-5 NITROSYLFLUORID FNO 49.00 FN=O 460-12-8 DIACETYLEN C4H2 50.06 C#CC#C 74-87-3 CHLORMETHAN CH3Cl 50.49 ClC 1070-71-9 CYANACETYLEN C3HN 51.05 N#CC#C 75-10-5 DIFLUORMETHAN CH2F2 52.02 FCF 460-19-5 ETHANDINITRIL C2N2 52.04 N#CC#N 689-97-4 1-BUTEN-3-IN C4H4 52.07 C#CC=C 7790-92-3 HYPOCHLORIGESAEURE HClO 52.46 ClO 107-13-1 ACRYLSAEURENITRIL C3H3N 53.06 N#CC=C 624-67-9 2-PROPINAL C3H2O 54.05 C#CC=O 107-00-6 1-BUTIN C4H6 54.09 CCC#C 503-17-3 2-BUTIN C4H6 54.09 CC#CC 106-99-0 1,3-BUTADIEN C4H6 54.09 C=CC=C 590-19-2 1,2-BUTADIEN C4H6 54.09 CC=C=C 822-35-5 CYCLOBUTEN C4H6 54.09 C1C=CC1 7790-89-8 CHLORFLUORID ClF 54.45 ClF 107-12-0 PROPIONSAEURENITRIL C3H5N 55.08 CCC#N 2450-71-7 PROPARAGYLAMIN C3H5N 55.08 NCC#C 593-90-8 TRIMETHYLBORAN C3H9B 55.92 CB(C)C 107-02-8 2-PROPENAL C3H4O 56.06 O=CC=C 107-19-7 2-PROPIN-1-OL C3H4O 56.06 OCC#C 6004-44-0 1-propen-1-one(methylketene) C3H4O 56.06 CC=C=O 540-61-4 ACETONITRILE,AMINO C2H4N2 56.07 NCC#N 115-11-7 2-METHYL-1-PROPEN C4H8 56.11 CC(C)=C 590-18-1 (2Z)-2-BUTEN C4H8 56.11 CC=CC 25167-67-3 butene C4H8 56.11 CCC=C 106-98-9 1-BUTEN C4H8 56.11 CCC=C 624-64-6 (2E)-2-BUTEN C4H8 56.11 CC=CC 594-11-6 METHYLCYCLOPROPAN C4H8 56.11 CC1CC1 287-23-0 CYCLOBUTAN C4H8 56.11 C1CCC1 624-83-9 ISOCYANATOMETHAN C2H3NO 57.05 CN=C=O 107-16-4 FORMALDEHYDCYANHYDRIN C2H3NO 57.05 OCC#N 765-30-0 CYCLOPROPANAMIN C3H7N 57.09 NC1CC1 75-55-8 2-METHYLAZIRIDIN C3H7N 57.09 CC1NC1 1072-44-2 1-methylaziridine C3H7N 57.09 CN1CC1 107-11-9 ALLYLAMIN C3H7N 57.09 NCC=C 503-29-7 AZACYCLOBUTAN C3H7N 57.09 N1CCC1 107-22-2 ETHANDIAL C2H2O2 58.04 O=CC=O 107-25-5 VINYLMETHYLETHER C3H6O 58.08 COC=C 107-18-6 2-PROPEN-1-OL C3H6O 58.08 OCC=C 123-38-6 PROPANAL C3H6O 58.08 CCC=O 75-56-9 METHYLOXIRAN C3H6O 58.08 CC1OC1 67-64-1 2-PROPANON C3H6O 58.08 CC(C)=O 503-30-0 OXETAN C3H6O 58.08 O1CCC1 503-28-6 DIMETHYLDIAZEN C2H6N2 58.08 CN=NC 124-42-5 ethanimidamide C2H6N2 58.08 CC(=N)N 75-28-5 2-METHYLPROPAN C4H10 58.12 CC(C)C 106-97-8 BUTAN C4H10 58.12 CCCC 107-29-9 ACETALDEHYDOXIM C2H5NO 59.07 ON=CC 123-39-7 N-METHYLFORMAMID C2H5NO 59.07 CNC=O 60-35-5 ESSIGSAEUREAMID C2H5NO 59.07 CC(=O)N 113-00-8 GUANIDIN CH5N3 59.07 N=C(N)N 463-56-9 THIOCYANSAEURE CHNS 59.09 SC#N 75-50-3 N,N-DIMETHYLMETHANAMIN C3H9N 59.11 CN(C)C 624-78-2 N-METHYLETHANAMIN C3H9N 59.11 CNCC 75-31-0 2-PROPANAMIN C3H9N 59.11 NC(C)C

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CAS Name Sufo MW Smiles 107-10-8 1-PROPYLAMIN C3H9N 59.11 NCCC 13061-96-6 DIHYDROXYMETHYLBORAN CH5BO2 59.86 OB(O)C 107-31-3 AMEISENSAEUREMETHYLESTER C2H4O2 60.05 COC=O 64-19-7 ESSIGSAEURE C2H4O2 60.05 OC(C)=O 141-46-8 HYDROXYACETALDEHYD C2H4O2 60.05 OCC=O 624-82-8 n-hydroxymethanimidamide CH4N2O 60.06 ON=CN 624-84-0 n-formylhydrazine CH4N2O 60.06 O=CNN 57-13-6 HARNSTOFF CH4N2O 60.06 O=C(N)N 818-92-8 3-FLUOR-1-PROPEN C3H5F 60.07 FCC=C 1184-60-7 2-FLUOR-1-PROPEN C3H5F 60.07 FC(C)=C 463-58-1 KOHLENOXIDSULFID COS 60.08 O=C=S 71-23-8 1-PROPANOL C3H8O 60.10 OCCC 67-63-0 2-PROPANOL C3H8O 60.10 OC(C)C 540-67-0 METHOXYETHAN C3H8O 60.10 COCC 57-14-7 N,N-DIMETHYLHYDRAZIN C2H8N2 60.10 CN(C)N 540-73-8 N,N`-DIMETHYLHYDRAZIN C2H8N2 60.10 CNNC 107-15-3 1,2-ETHANDIAMIN C2H8N2 60.10 NCCN 420-12-2 THIACYCLOPROPAN C2H4S 60.12 S1CC1 1111-74-6 DIMETHYLSILAN C2H8Si 60.17 C[SiH2]C 593-63-5 ETHINYLCHLORID C2HCl 60.48 ClC#C 624-91-9 METHYLNITRIT CH3NO2 61.04 CON=O 75-52-5 NITROMETHAN CH3NO2 61.04 CN(=O)=O 16645-06-0 n,n-dimethylhydroxylamine C2H7NO 61.08 ON(C)C 5725-96-2 DIMETHYLHYDROXYLAMIN C2H7NO 61.08 ON(C)C 1117-97-1 METHOXYMETHYLAMIN C2H7NO 61.08 CONC 141-43-5 2-AMINOETHANOL C2H7NO 61.08 OCCN 75-39-8 acetaldehydeammonia C2H7NO 61.08 OC(N)C 115-08-2 thioformamide CH3NS 61.11 NC=S 506-77-4 CYANOGENCHLORID((CN)CL) CClN 61.47 ClC#N 10043-35-3 BORSAEURE(H3BO3) H3BO3 61.83 OB(O)O 557-99-3 ACETYLFLUORID C2H3FO 62.04 FC(C)=O 690-02-8 DIMETHYLPEROXID C2H6O2 62.07 COOC 3031-74-1 ETHYLHYDROPEROXID C2H6O2 62.07 OOCC 107-21-1 1,2-ETHANDIOL C2H6O2 62.07 OCCO 460-13-9 1-FLUORPROPAN C3H7F 62.09 FCCC 75-08-1 ETHANTHIOL C2H6S 62.13 CCS 75-18-3 THIOBISMETHAN C2H6S 62.13 CSC 1590-87-0 DISILAN H6Si2 62.22 [SiH3][SiH3] 75-01-4 CHLORETHEN C2H3Cl 62.50 ClC=C 7697-37-2 SALPETERSAEURE HNO3 63.01 ON(=O)=O 75-38-7 1,1-DIFLUORETHEN C2H2F2 64.03 FC(F)=C 7446-09-5 SCHWEFELDIOXID O2S 64.06 O=S=O 371-62-0 2-FLUORETHANOL C2H5FO 64.06 FCCO 2565-30-2 FORMYLCHLORID CHClO 64.47 ClC=O 75-00-3 CHLORETHAN C2H5Cl 64.51 CCCl 2696-92-6 NITROSYLCHLORID((NO)CL) ClNO 65.46 ClN=O 6154-14-9 n-chloro-methanamine CH4ClN 65.50 CNCl 13445-50-6 DIPHOSPHIN H4P2 65.98 PP 6303-21-5 UNTERPHOSPHORIGE_SAEURE H3O2P 66.00 O[PH2]=O 13812-43-6 (Z)-DIFLUORDIAZIN F2N2 66.01 FN=NF 13776-62-0 (E)-DIFLUORDIAZIN F2N2 66.01 FN=NF 353-50-4 KOHLENSAEUREDIFLUORID CF2O 66.01 FC(F)=O 624-72-6 1,2-DIFLUORETHAN C2H4F2 66.05 FCCF 75-37-6 1,1-DIFLUORETHAN C2H4F2 66.05 FC(F)C 109-77-3 PROPANDINITRIL C3H2N2 66.06 N#CCC#N 1574-40-9 (3Z)-3-PENTEN-1-IN C5H6 66.10 CC=CC#C 2004-69-5 (3E)-3-PENTEN-1-IN C5H6 66.10 CC=CC#C 78-80-8 5-METHYL-3-BUTEN-1-IN C5H6 66.10 CC(=C)C#C 871-28-3 1-PENTEN-4-IN C5H6 66.10 C#CCC=C 646-05-9 1-PENTEN-3-IN C5H6 66.10 CC#CC=C 542-92-7 1,3-CYCLOPENTADIEN C5H6 66.10 C1C=CC=C1 13465-78-6 CHLORSILAN H3ClSi 66.56 Cl[SiH3]

Page 3 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 126-98-7 METHACRYLSAEURENITRIL C4H5N 67.09 CC(=C)C#N 1190-76-7 (2Z)-2-BUTENNITRIL C4H5N 67.09 CC=CC#N 627-26-9 (2E)-2-BUTENNITRIL C4H5N 67.09 CC=CC#N 109-75-1 3-BUTENNITRIL C4H5N 67.09 N#CCC=C 109-97-7 PYRROL C4H5N 67.09 c1c[nH]cc1 5500-21-0 CYCLOPROPYLCYANID C4H5N 67.09 N#CC1CC1 10049-04-4 CHLOROXID(CLO2) ClO2 67.45 O=[Cl+]=O 7637-07-2 TRIFLUORBORAN BF3 67.81 FB(F)F 504-64-3 KOHLENSUBOXID C3O2 68.03 O=C=C=C=O 110-00-9 FURAN C4H4O 68.07 c1cocc1 1423-60-5 3-butyn-2-one C4H4O 68.07 CC(=O)C#C 288-13-1 1H-PYRAZOL C3H4N2 68.08 c1n[nH]cc1 109-82-0 acetonitrile,(methyleneamino)- C3H4N2 68.08 N#CCN=C 288-32-4 1H-IMIDAZOL C3H4N2 68.08 n1c[nH]cc1 627-19-0 1-PENTIN C5H8 68.12 CCCC#C 598-23-2 3-METHYL-1-BUTIN C5H8 68.12 CC(C)C#C 627-21-4 2-PENTIN C5H8 68.12 CCC#CC 1574-41-0 (3Z)-1,3-PENTADIEN C5H8 68.12 CC=CC=C 591-93-5 1,4-PENTADIEN C5H8 68.12 C=CCC=C 2004-70-8 (3E)-1,3-PENTADIEN C5H8 68.12 CC=CC=C 78-79-5 2-METHYL-1,3-BUTADIEN C5H8 68.12 CC(=C)C=C 591-95-7 1,2-PENTADIEN C5H8 68.12 CCC=C=C 598-25-4 3-METHYL-1,2-BUTADIEN C5H8 68.12 CC(C)=C=C 591-96-8 2,3-PENTADIEN C5H8 68.12 CC=C=CC 1120-56-5 METHYLENCYCLOBUTAN C5H8 68.12 C=C1CCC1 142-29-0 CYCLOPENTEN C5H8 68.12 C1CC=CC1 157-40-4 SPIROPENTAN C5H8 68.12 C1CC21CC2 185-94-4 BICYCLO-(2.1.0)-PENTAN C5H8 68.12 C2C1CC1C2 593-70-4 CHLORFLUORMETHAN CH2ClF 68.48 FCCl 288-42-6 OXAZOL C3H3NO 69.06 n1cocc1 288-14-2 ISOXAZOL C3H3NO 69.06 c1nocc1 631-57-2 propanenitrile,2-oxo- C3H3NO 69.06 CC(=O)C#N 288-36-8 1H-1,2,3-TRIAZOL C2H3N3 69.07 n1n[nH]cc1 288-88-0 1H-1,2,4-TRIAZOL C2H3N3 69.07 n1c[nH]cn1 109-74-0 BUTANNITRIL C4H7N 69.11 CCCC#N 78-82-0 2-CYANOPROPAN C4H7N 69.11 CC(C)C#N 35161-71-8 2-propyn-1-amine,n-methyl- C4H7N 69.11 CNCC#C 109-96-6 2,5-DIHYDRO-1H-PYRROL C4H7N 69.11 N1CC=CC1 5724-81-2 3,4-dihydro-2h-pyrrole C4H7N 69.11 C1CN=CC1 5518-25-2 diethylborane C4H11B 69.94 CCBCC 75-46-7 TRIFLUORMETHAN CHF3 70.01 FC(F)F 471-25-0 PROPIOLSAEURE C3H2O2 70.05 OC(=O)C#C 288-37-9 furazan C2H2N2O 70.05 c1nonc1 288-94-8 TETRAAZACYCLOPENTADIEN CH2N4 70.05 n1n[nH]cn1 927-80-0 ETHOXYETHIN C4H6O 70.09 CCOC#C 109-93-3 DIVINYLETHER C4H6O 70.09 C=COC=C 1191-99-7 2,3-DIHYDROFURAN C4H6O 70.09 C1CC=CO1 930-22-3 1,3-BUTADIENMONOXID C4H6O 70.09 C=CC1OC1 764-01-2 2-BUTIN-1-OL C4H6O 70.09 OCC#CC 627-41-8 3-methoxy-propyne C4H6O 70.09 COCC#C 2028-63-9 3-BUTIN-2-OL C4H6O 70.09 OC(C)C#C 78-85-3 2-METHYL-2-PROPENAL C4H6O 70.09 CC(=C)C=O 927-74-2 3-BUTIN-1-OL C4H6O 70.09 OCCC#C 1191-95-3 CYCLOBUTANON C4H6O 70.09 O=C1CCC1 78-94-4 3-BUTEN-2-ON C4H6O 70.09 CC(=O)C=C 123-73-9 (2E)-2-BUTENAL C4H6O 70.09 CC=CC=O 1708-29-8 2,5-DIHYDROFURAN C4H6O 70.09 O1CC=CC1 15798-64-8 2-BUTENAL,(Z)- C4H6O 70.09 CC=CC=O 109-98-8 PYRAZOLIN C3H6N2 70.09 C1C=NNC1 1467-79-4 DIMETHYLCYANAMID C3H6N2 70.09 CN(C)C#N 151-18-8 3-AMINOPROPIONITRIL C3H6N2 70.09 NCCC#N 20334-52-5 1-buten-1-one(ethylketene) C4H6O 70.09 CCC=C=O

Page 4 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 598-26-5 2-methyl-1-propen-1-one(dimethylketene) C4H6O 70.09 CC(C)=C=O 563-46-2 2-METHYL-1-BUTEN C5H10 70.13 CCC(C)=C 513-35-9 2-METHYL-2-BUTEN C5H10 70.13 CC=C(C)C 109-67-1 1-PENTEN C5H10 70.13 CCCC=C 627-20-3 (2Z)-2-PENTEN C5H10 70.13 CCC=CC 563-45-1 3-METHYL-1-BUTEN C5H10 70.13 CC(C)C=C 646-04-8 (2E)-2-PENTEN C5H10 70.13 CCC=CC 1191-96-4 ETHYLCYCLOPROPAN C5H10 70.13 CCC1CC1 1630-94-0 1,1-DIMETHYLCYCLOPROPAN C5H10 70.13 CC1(C)CC1 2402-06-4 TRANS-1,2-DIMETHYLCYCLOPROPAN C5H10 70.13 CC1CC1C 598-61-8 METHYLCYCLOBUTAN C5H10 70.13 CC1CCC1 287-92-3 CYCLOPENTAN C5H10 70.13 C1CCCC1 7782-50-5 CHLOR Cl2 70.91 ClCl 7783-54-2 STICKSTOFFFLUORID(NF3) F3N 71.00 FN(F)F 109-90-0 ISOCYANATOETHAN C3H5NO 71.08 CCN=C=O 627-48-5 cyanicacid,ethylester C3H5NO 71.08 CCOC#N 1738-36-9 METHOXYACETONITRIL C3H5NO 71.08 COCC#N 930-21-2 2-azetidinone C3H5NO 71.08 O=C1NCC1 78-97-7 2-HYDROXYPROPANNITRIL C3H5NO 71.08 OC(C)C#N 79-06-1 2-PROPENAMID C3H5NO 71.08 C=CC(=O)N 109-78-4 3-HYDROXYPROPIONITRIL C3H5NO 71.08 OCCC#N 627-37-2 n-methylallylamine C4H9N 71.12 CNCC=C 2658-24-4 2,2-dimethylethylenimine C4H9N 71.12 CC1(C)NC1 2549-67-9 2-ethylaziridine C4H9N 71.12 CCC1NC1 2516-34-9 CYCLOBUTANAMIN C4H9N 71.12 NC1CCC1 123-75-1 PYRROLIDIN C4H9N 71.12 N1CCCC1 692-45-5 AMEISENSAEUREVINYLESTER C3H4O2 72.06 O=COC=C 78-98-8 1,2-PROPANDION C3H4O2 72.06 CC(=O)C=O 79-10-7 2-PROPENSAEURE C3H4O2 72.06 OC(=O)C=C 765-34-4 glycidylaldehyde C3H4O2 72.06 O=CC1OC1 57-57-8 2-OXETANON C3H4O2 72.06 O=C1CCO1 381-61-3 1,3-butadiene,2-fluoro- C4H5F 72.08 FC(=C)C=C 75-24-1 TRIMETHYLALUMINIUM C3H9Al 72.09 C[Al](C)C 109-92-2 VINYLETHYLETHER C4H8O 72.11 CCOC=C 116-11-0 2-METHOXY-1-PROPEN C4H8O 72.11 COC(C)=C 2919-23-5 CYCLOBUTANOL C4H8O 72.11 OC1CCC1 513-42-8 2-METHYL-2-PROPEN-1-OL C4H8O 72.11 OCC(C)=C 6117-91-5 2-BUTEN-1-OL C4H8O 72.11 OCC=CC 627-27-0 1-BUTEN-4-OL C4H8O 72.11 OCCC=C 540-47-6 METHOXYCYCLOPROPAN C4H8O 72.11 COC1CC1 627-40-7 ALLYLMETHYLETHER C4H8O 72.11 COCC=C 78-84-2 2-METHYLPROPANAL C4H8O 72.11 CC(C)C=O 106-88-7 1,2-BUTENOXID C4H8O 72.11 CCC1OC1 123-72-8 BUTANAL C4H8O 72.11 CCCC=O 558-30-5 ISOBUTENOXID C4H8O 72.11 CC1(C)OC1 1758-33-4 CIS-2-BUTENOXID C4H8O 72.11 CC1OC1C 21490-63-1 TRANS-2,3-DIMETHYLOXIRAN C4H8O 72.11 CC1OC1C 78-93-3 2-BUTANON C4H8O 72.11 CCC(C)=O 2167-39-7 1,3-butyleneoxide C4H8O 72.11 CC1CCO1 109-99-9 TETRAHYDROFURAN C4H8O 72.11 O1CCCC1 463-82-1 2,2-DIMETHYLPROPAN C5H12 72.15 CC(C)(C)C 78-78-4 2-METHYLBUTAN C5H12 72.15 CCC(C)C 109-66-0 PENTAN C5H12 72.15 CCCCC 3638-64-0 NITROETHEN C2H3NO2 73.05 C=CN(=O)=O 127-06-0 2-PROPANONOXIM C3H7NO 73.09 ON=C(C)C 627-39-4 PROPIONALDOXIM C3H7NO 73.09 CCC=NO 68-12-2 N,N-DIMETHYLFORMAMID C3H7NO 73.09 CN(C)C=O 627-45-2 N-ETHYLFORMAMID C3H7NO 73.09 CCNC=O 79-16-3 N-METHYLACETAMID C3H7NO 73.09 CNC(C)=O 79-05-0 PROPIONSAEUREAMID C3H7NO 73.09 CCC(=O)N 471-29-4 methylguanidine C2H7N3 73.10 CNC(=N)N 556-61-6 ISOTHIOCYANATOMETHAN C2H3NS 73.12 CN=C=S

Page 5 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 556-64-9 THIOCYANSAEUREMETHYLESTER C2H3NS 73.12 CSC#N 598-56-1 N,N-DIMETHYLETHANAMIN C4H11N 73.14 CCN(C)C 627-35-0 N-METHYL-1-PROPANAMIN C4H11N 73.14 CNCCC 109-89-7 N-ETHYLETHANAMIN C4H11N 73.14 CCNCC 4747-21-1 N-ISOPROPYLMETHYLAMIN C4H11N 73.14 CNC(C)C 13952-84-6 2-BUTANAMIN C4H11N 73.14 CCC(N)C 513-49-5 2-butanamine C4H11N 73.14 CCC(N)C 78-81-9 2-METHYL-1-PROPANAMIN C4H11N 73.14 NCC(C)C 109-73-9 1-BUTYLAMIN C4H11N 73.14 NCCCC 75-64-9 2-AMINO-2-METHYLPROPAN C4H11N 73.14 NC(C)(C)C 4542-61-4 DIMETHOXYBORAN C2H7BO2 73.89 COBOC 4433-63-0 ethyl-boronicacid C2H7BO2 73.89 CCB(O)O 298-12-4 GLYOXYLSAEURE C2H2O3 74.04 OC(=O)C=O 79-09-4 PROPANSAEURE C3H6O2 74.08 CCC(O)=O 109-94-4 AMEISENSAEUREETHYLESTER C3H6O2 74.08 CCOC=O 79-20-9 ESSIGSAEUREMETHYLESTER C3H6O2 74.08 COC(C)=O 646-06-0 1,3-DIOXOLAN C3H6O2 74.08 C1OCCO1 62-75-9 N-METHYL-N-NITROSOMETHANAMIN C2H6N2O 74.08 CN(C)N=O 116-09-6 HYDROXYPROPANON C3H6O2 74.08 OCC(C)=O 556-52-5 2,3-EPOXYPROPANOL C3H6O2 74.08 OCC1OC1 1068-57-1 aceticacidhydrazide C2H6N2O 74.08 CC(=O)NN 598-50-5 METHYLHARNSTOFF C2H6N2O 74.08 CNC(=O)N 78-83-1 2-METHYL-1-PROPANOL C4H10O 74.12 OCC(C)C 71-36-3 1-BUTANOL C4H10O 74.12 OCCCC 78-92-2 2-BUTANOL C4H10O 74.12 CCC(O)C 75-65-0 2-METHYL-2-PROPANOL C4H10O 74.12 OC(C)(C)C 60-29-7 DIETHYLETHER C4H10O 74.12 CCOCC 557-17-5 1-METHOXYPROPAN C4H10O 74.12 COCCC 598-53-8 METHYLISOPROPYLETHER C4H10O 74.12 COC(C)C 78-90-0 1,2-PROPANDIAMIN C3H10N2 74.13 NCC(N)C 109-81-9 N-METHYL-1,2-ETHANDIAMIN C3H10N2 74.13 CNCCN 109-76-2 1,3-PROPANDIAMIN C3H10N2 74.13 NCCCN 287-27-4 THIETAN C3H6S 74.15 C1CSC1 870-23-5 2-PROPEN-1-THIOL C3H6S 74.15 SCC=C 1072-43-1 2-METHYLTHIACYCLOPROPAN C3H6S 74.15 CC1CS1 993-07-7 TRIMETHYLSILAN C3H10Si 74.20 C[SiH](C)C 3223-70-9 chloroallene C3H3Cl 74.51 ClC=C=C 624-65-7 3-CHLOR-1-PROPIN C3H3Cl 74.51 ClCC#C 7747-84-4 1-CHLOR-1-PROPIN C3H3Cl 74.51 CC#CCl 79-24-3 NITROETHAN C2H5NO2 75.07 CCN(=O)=O 109-95-5 SALPETRIGSAEUREETHYLESTER C2H5NO2 75.07 CCON=O 598-55-0 CARBAMIDSAEUREMETHYLESTER C2H5NO2 75.07 COC(=O)N 563-41-7 semicarbazide CH5N3O 75.07 NNC(=O)N 546-88-3 acetamide,n-hydroxy- C2H5NO2 75.07 ONC(C)=O 56-40-6 GLYCIN C2H5NO2 75.07 [NH3+]CC([O-])=O 64253-39-0 cyanosulfoxylicacid CHNOS 75.09 OSC#N 109-83-1 N-METHYLETHANOLAMIN C3H9NO 75.11 OCCNC 78-96-6 2-HYDROXYPROPYLAMIN C3H9NO 75.11 NCC(O)C 6168-72-5 1-propanol,2-amino-,(.+-.)- C3H9NO 75.11 OCC(N)C 78-91-1 2-AMINOPROPANOL C3H9NO 75.11 OCC(N)C 109-85-3 2-METHOXYETHANAMIN C3H9NO 75.11 COCCN 1184-78-7 n,n-dimethylmethanamine-n-oxide C3H9NO 75.11 CN(C)(C)=O 156-87-6 3-AMINO-1-PROPANOL C3H9NO 75.11 OCCCN 62-55-5 ETHANTHIOAMID C2H5NS 75.13 CC(N)=S 2875-98-1 DIMETHYLSILYLAMIN C2H9NSi 75.19 CN(C)[SiH3] 107-14-2 CHLORACETONITRIL C2H2ClN 75.50 ClCC#N 10544-73-7 STICKSTOFFOXID(N2O3) N2O3 76.01 0.00 79-21-0 PERESSIGSAEURE C2H4O3 76.05 OOC(C)=O 7456-87-3 ch3oc(o)oh C2H4O3 76.05 COC(O)=O 598-57-2 N-NITROMETHANAMIN CH4N2O2 76.05 NCN(=O)=O 79-14-1 2-HYDROXYESSIGSAEURE C2H4O3 76.05 OCC(O)=O 127-07-1 hydroxyurea CH4N2O2 76.05 ONC(=O)N

Page 6 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 1071-98-3 DICYANOACETYLEN C4N2 76.06 N#CC#CC#N 430-71-7 PROPANOYLFLUORID C3H5FO 76.07 CCC(F)=O 503-09-3 1-FLUOR-2,3-EPOXYPROPAN C3H5FO 76.07 FCC1OC1 430-51-3 fluoroacetone C3H5FO 76.07 FCC(C)=O 594-09-2 TRIMETHYLPHOSPHIN C3H9P 76.08 CP(C)C 109-86-4 ETHYLENGLYKOLMONOMETHYLETHER C3H8O2 76.09 COCCO 109-87-5 DIMETHOXYMETHAN C3H8O2 76.09 COCOC 57-55-6 1,2-PROPANDIOL C3H8O2 76.09 OCC(O)C 504-63-2 1,3-PROPANDIOL C3H8O2 76.09 OCCCO 109-84-2 2-HYDRAZINOETHANOL C2H8N2O 76.10 OCCNN 2366-52-1 1-FLUORBUTAN C4H9F 76.11 FCCCC 507-09-5 THIOETHANSAEURE C2H4OS 76.12 CC(S)=O 62-56-6 THIOHARNSTOFF CH4N2S 76.12 NC(N)=S 75-15-0 KOHLENDISULFID CS2 76.14 S=C=S 75-33-2 2-PROPANTHIOL C3H8S 76.16 CC(C)S 624-89-5 (METHYLTHIO)ETHAN C3H8S 76.16 CCSC 107-03-9 1-PROPANTHIOL C3H8S 76.16 CCCS 1803-36-7 dimethylchloroborane C2H6BCl 76.33 CB(C)Cl 107-05-1 3-CHLOR-1-PROPEN C3H5Cl 76.53 ClCC=C 590-21-6 1-CHLOR-1-PROPEN C3H5Cl 76.53 CC=CCl 557-98-2 2-CHLOR-1-PROPEN C3H5Cl 76.53 CC(Cl)=C 7782-65-2 GERMAN H4Ge 76.67 [GeH4] 598-58-3 SALPETERSAEUREMETHYLESTER CH3NO3 77.04 CON(=O)=O 640-19-7 2-FLUORACETAMID C2H4FNO 77.06 FCC(=O)N 60-23-1 2-aminoethanethiol C2H7NS 77.15 NCCS 7784-42-1 ARSIN H3As 77.95 [AsH3] 7127-18-6 DIFLUORCYANAMID CF2N2 78.02 FN(F)C#N 144-49-0 FLUORESSIGSAEURE C2H3FO2 78.04 FCC(O)=O 764-42-1 (2E)-2-BUTENDINITRIL C4H2N2 78.07 N#CC=CC#N 928-53-0 MALEINSAEUREDINITRIL C4H2N2 78.07 N#CC=CC#N 462-43-1 3-FLUOROPROPYLALCOHOL C3H7FO 78.09 FCCCO 10420-90-3 1,3-HEXADIEN-5-IN C6H6 78.11 C#CC=CC=C 628-16-0 1,5-HEXADIIN C6H6 78.11 C#CCCC#C 2809-69-0 2,4-HEXADIIN C6H6 78.11 CC#CC#CC 821-08-9 1,5-HEXADIEN-3-IN C6H6 78.11 C=CC#CC=C 71-43-2 BENZOL C6H6 78.11 c1ccccc1 60-24-2 2-MERCAPTOETHANOL C2H6OS 78.13 OCCS 67-68-5 SULFINYLBISMETHAN C2H6OS 78.13 CS(C)=O 13597-73-4 DISILOXAN H6OSi2 78.22 [SiH3]O[SiH3] 75-36-5 ACETYLCHLORID C2H3ClO 78.50 CC(Cl)=O 107-20-0 CHLORACETALDEHYD C2H3ClO 78.50 ClCC=O 75-29-6 2-CHLORPROPAN C3H7Cl 78.54 CC(C)Cl 540-54-5 1-PROPYLCHLORID C3H7Cl 78.54 CCCCl 1615-70-9 2,4-pentadienenitrile C5H5N 79.10 N#CC=CC=C 110-86-1 PYRIDIN C5H5N 79.10 n1ccccc1 463-72-9 CARBAMICCHLORIDE CH2ClNO 79.49 ClC(=O)N 4206-94-4 methylphosphinicacid CH5O2P 80.02 OP(O)C 430-69-3 difluoroacetaldehyde C2H2F2O 80.03 FC(F)C=O 7446-11-9 SCHWEFELTRIOXID O3S 80.06 O=S(=O)=O 462-39-5 1,3-DIFLUORPROPAN C3H6F2 80.08 FCCCF 420-45-1 2,2-DIFLUORPROPAN C3H6F2 80.08 FC(F)(C)C 290-37-9 PYRAZIN C4H4N2 80.09 c1nccnc1 289-95-2 PYRIMIDIN C4H4N2 80.09 c1ncccn1 289-80-5 PYRIDAZIN C4H4N2 80.09 n1ccccn1 110-61-2 BUTANDINITRIL C4H4N2 80.09 N#CCCC#N 1574-33-0 3-METHYL-3-PENTEN-1-IN C6H8 80.13 CC=C(C)C#C 14092-20-7 2-HEXEN-4-IN C6H8 80.13 CC#CC=CC 821-07-8 (E)-1,3,5-HEXATRIEN C6H8 80.13 C=CC=CC=C 2612-46-6 (3Z)-1,3,5-HEXATRIEN C6H8 80.13 C=CC=CC=C 2235-12-3 1,3,5-HEXATRIEN C6H8 80.13 C=CC=CC=C 13721-54-5 1-hexen-3-yne C6H8 80.13 CCC#CC=C 26519-91-5 1-METHYL-1,3-CYCLOPENTADIEN C6H8 80.13 CC1=CCC=C1

Page 7 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 628-41-1 1,4-CYCLOHEXADIEN C6H8 80.13 C1C=CCC=C1 592-57-4 1,3-CYCLOHEXADIEN C6H8 80.13 C1C=CC=CC1 14296-80-1 cyclobutane,1,2-bis(methylene)- C6H8 80.13 C=C1CCC1=C 6725-64-0 METHANDITHIOL CH4S2 80.17 SCS 107-30-2 CHLORMETHOXYMETHAN C2H5ClO 80.51 COCCl 107-07-3 2-CHLORETHANOL C2H5ClO 80.51 OCCCl 993-00-0 CHLORMETHYLSILAN CH5ClSi 80.59 C[SiH2]Cl 10035-10-6 BROMWASSERSTOFFSAEURE HBr 80.91 Br 7783-07-5 SELENWASSERSTOFF(H2SE) H2Se 80.98 [SeH2] 290-87-9 1,3,5-TRIAZIN C3H3N3 81.08 n1cncnc1 96-54-8 1-METHYLPYRROL C5H7N 81.12 Cn1cccc1 592-51-8 4-PENTENNITRIL C5H7N 81.12 N#CCCC=C 4426-11-3 CYCLOBUTYLNITRIL C5H7N 81.12 N#CC1CCC1 13598-36-2 PHOSPHORIGESAEURE H3O3P 82.00 O[PH](O)=O 359-11-5 TRIFLUORETHEN C2HF3 82.02 FC=C(F)F 359-15-9 DIFLUORMETHOXYMETHAN C2H4F2O 82.05 COC(F)F 359-13-7 2,2-DIFLUORETHANOL C2H4F2O 82.05 OCC(F)F 930-27-8 3-METHYLFURAN C5H6O 82.10 Cc1cocc1 7554-65-6 4-METHYLPYRAZOL C4H6N2 82.10 Cc1c[nH]nc1 930-30-3 CYCLO-2-PENTEN-1-ON C5H6O 82.10 O=C1C=CCC1 930-36-9 1-METHYL-1H-PYRAZOL C4H6N2 82.10 Cn1cccn1 534-22-5 2-METHYLFURAN C5H6O 82.10 Cc1occc1 616-47-7 1-METHYL-1H-IMIDAZOL C4H6N2 82.10 Cn1ccnc1 822-36-6 4-METHYLIMIDAZOL C4H6N2 82.10 Cc1c[nH]cn1 693-98-1 2-METHYL-1H-IMIDAZOL C4H6N2 82.10 Cc1[nH]ccn1 693-02-7 1-HEXIN C6H10 82.14 CCCCC#C 7154-75-8 4-METHYL-1-PENTIN C6H10 82.14 CC(C)CC#C 917-92-0 3,3-DIMETHYL-1-BUTIN C6H10 82.14 CC(C)(C)C#C 764-35-2 2-HEXIN C6H10 82.14 CCCC#CC 928-49-4 3-HEXIN C6H10 82.14 CCC#CCC 926-56-7 4-METHYL-1,3-PENTADIEN C6H10 82.14 CC(C)=CC=C 4663-22-3 cyclopropane,(1-methylethenyl)- C6H10 82.14 CC(C1CC1)=C 1115-08-8 3-METHYL-1,4-PENTADIENE C6H10 82.14 CC(C=C)C=C 592-42-7 1,5-HEXADIEN C6H10 82.14 C=CCCC=C 5194-50-3 CIS,TRANS-2,4-HEXADIEN C6H10 82.14 CC=CC=CC 763-30-4 2-METHYL-1,4-PENTADIEN C6H10 82.14 CC(CC=C)=C 5194-51-4 (2E,4E)-2,4-HEXADIEN C6H10 82.14 CC=CC=CC 926-54-5 (3E)-1,3-PENTADIENE,2-METHYL- C6H10 82.14 CC=CC(C)=C 592-45-0 1,4-HEXADIEN C6H10 82.14 CC=CCC=C 20237-34-7 (3E)-1,3-HEXADIEN C6H10 82.14 CCC=CC=C 7319-00-8 (4E)-1,4-HEXADIEN C6H10 82.14 CC=CCC=C 4549-74-0 3-METHYL-1,3-PENTADIEN C6H10 82.14 CC=C(C)C=C 513-81-5 2,3-DIMETHYL-1,3-BUTADIEN C6H10 82.14 CC(=C)C(C)=C 592-44-9 1,2-HEXADIENE C6H10 82.14 CCCC=C=C 7417-48-3 3-METHYL-1,2-PENTADIEN C6H10 82.14 CCC(C)=C=C 1528-30-9 METHYLENCYCLOPENTAN C6H10 82.14 C=C1CCCC1 110-83-8 CYCLOHEXEN C6H10 82.14 C1CC=CCC1 1759-81-5 4-METHYLCYCLOPENTEN C6H10 82.14 CC1CC=CC1 1120-62-3 3-METHYLCYCLOPENTEN C6H10 82.14 CC1C=CCC1 693-89-0 1-METHYLCYCLOPENTEN C6H10 82.14 CC1=CCCC1 762-50-5 1-FLUOR-2-CHLORETHAN C2H4ClF 82.50 FCCCl 1615-75-4 1-CHLOR-1-FLUORETHAN C2H4ClF 82.50 FC(C)Cl 5765-44-6 5-METHYLISOXAZOL C4H5NO 83.09 Cc1oncc1 693-93-6 4-METHYLOXAZOL C4H5NO 83.09 Cc1cocn1 5809-59-6 3-BUTENENITRILE,2-HYDROXY- C4H5NO 83.09 OC(C#N)C=C 28466-26-4 4-aminopyrazole C3H5N3 83.09 Nc1c[nH]nc1 110-59-8 PENTANNITRIL C5H9N 83.13 CCCCC#N 625-28-5 3-METHYLBUTANNITRIL C5H9N 83.13 CC(C)CC#N 18936-17-9 2-METHYLBUTANNITRIL C5H9N 83.13 CCC(C)C#N 630-18-2 TRIMETHYLACETONITRIL C5H9N 83.13 CC(C)(C)C#N 2978-58-7 1,1-DIMETHYLPROPINYLAMIN C5H9N 83.13 NC(C)(C)C#C 694-05-3 1,2,3,6-TETRAHYDROPYRIDIN C5H9N 83.13 N1CC=CCC1

Page 8 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 7439-90-9 KRYPTON Kr 83.80 [Kr] 430-66-0 1,1,2-TRIFLUORETHAN C2H3F3 84.04 FCC(F)F 420-46-2 1,1,1-TRIFLUORETHAN C2H3F3 84.04 FC(F)(F)C 674-82-8 4-METHYLEN-2-OXETANON C4H4O2 84.07 O=C1CC(O1)=C 33689-28-0 1,2-cyclobutanedione C4H4O2 84.07 O=C1CCC1=O 20825-71-2 CROTONOLACTON C4H4O2 84.07 O=C1CC=CO1 590-93-2 2-butynoicacid C4H4O2 84.07 CC#CC(O)=O 2363-83-9 trans-butenedial C4H4O2 84.07 O=CC=CC=O 3675-13-6 cis-butenedial C4H4O2 84.07 O=CC=CC=O 497-23-4 2(5h)-furanone C4H4O2 84.07 O=C1C=CCO1 15506-53-3 CYCLOBUTA-1,3-DION C4H4O2 84.07 O=C1CC(C1)=O 4570-45-0 oxazole-2-amine C3H4N2O 84.08 Nc1occn1 4076-36-2 5-METHYL-1H-TETRAZOL C2H4N4 84.08 Cc1[nH]nnn1 16681-77-9 1-METHYL-1H-TETRAZOL C2H4N4 84.08 Cn1cnnn1 61-82-5 1H-1,2,4-TRIAZOL-3-AMIN C2H4N4 84.08 Nc1n[nH]cn1 461-58-5 CYANGUANIDIN C2H4N4 84.08 N#CNC(=N)N 107-91-5 CYANACETAMID C3H4N2O 84.08 N#CCC(=O)N 627-52-1 sulfurcyanide C2N2S 84.10 N#CSC#N 3036-66-6 1-methoxy-1,3-butadiene C5H8O 84.12 COC=CC=C 3917-15-5 3-(ETHENYLOXY)-1-PROPEN C5H8O 84.12 C=COCC=C 110-87-2 3,4-DIHYDRO-2H-PYRAN C5H8O 84.12 C1OC=CCC1 16545-67-8 cyclopropylvinylether C5H8O 84.12 C=COC1CC1 922-65-6 1,4-pentadien-3-ol C5H8O 84.12 OC(C=C)C=C 115-19-5 2-METHYL-3-BUTIN-2-OL C5H8O 84.12 OC(C)(C)C#C 4187-86-4 pent-1-yn-3-ol C5H8O 84.12 CCC(O)C#C 10229-10-4 3-PENTIN-1-OL C5H8O 84.12 OCCC#CC 5390-04-5 pent-4-yn-1-ol C5H8O 84.12 OCCCC#C 2100-17-6 4-PENTENAL C5H8O 84.12 O=CCCC=C 285-67-6 6-OXABICYCLO(3.1.0)HEXAN C5H8O 84.12 C2CC1OC1C2 922-63-4 2-ETHYLACROLEIN C5H8O 84.12 CCC(=C)C=O 1629-58-9 1-PENTEN-3-ON C5H8O 84.12 CCC(=O)C=C 814-78-8 3-METHYL-3-BUTEN-2-ON C5H8O 84.12 CC(=O)C(C)=C 497-03-0 (2E)-2-METHYL-2-BUTENAL C5H8O 84.12 CC=C(C)C=O 1115-11-3 TIGLINALDEHYD C5H8O 84.12 CC=C(C)C=O 120-92-3 CYCLOPENTANON C5H8O 84.12 O=C1CCCC1 625-33-2 METHYLPROPENYLKETONE C5H8O 84.12 CC=CC(C)=O 765-43-5 METHYLCYCLOPROPYLKETON C5H8O 84.12 CC(C1CC1)=O 3102-33-8 3-penten-2-one,(e)- C5H8O 84.12 CC=CC(C)=O 926-64-7 (DIMETHYLAMINO)ACETONITRIL C4H8N2 84.12 CN(C)CC#N 107-86-8 3-METHYL-2-BUTENAL C5H8O 84.12 CC(C)=CC=O 534-26-9 2-METHYLIMIDAZOLIN C4H8N2 84.12 CC1=NCCN1 110-02-1 THIOPHEN C4H4S 84.14 c1cscc1 763-29-1 2-METHYL-1-PENTEN C6H12 84.16 CCCC(C)=C 760-21-4 3-METHYLENPENTAN C6H12 84.16 CCC(CC)=C 563-78-0 2,3-DIMETHYL-1-BUTEN C6H12 84.16 CC(C)C(C)=C 7688-21-3 (2Z)-2-HEXEN C6H12 84.16 CCCC=CC 558-37-2 3,3-DIMETHYL-1-BUTEN C6H12 84.16 CC(C)(C)C=C 592-41-6 1-HEXEN C6H12 84.16 CCCCC=C 563-79-1 2,3-DIMETHYL-2-BUTEN C6H12 84.16 CC(C)=C(C)C 691-38-3 (2Z)-4-METHYL-2-PENTEN C6H12 84.16 CC(C)C=CC 592-47-2 3-HEXEN C6H12 84.16 CCC=CCC 760-20-3 3-METHYL-1-PENTEN C6H12 84.16 CCC(C)C=C 922-62-3 3-METHYL-CIS-2-PENTEN C6H12 84.16 CCC(C)=CC 616-12-6 (2E)-3-METHYL-2-PENTEN C6H12 84.16 CCC(C)=CC 691-37-2 4-METHYL-1-PENTEN C6H12 84.16 CC(C)CC=C 625-27-4 2-METHYL-2-PENTEN C6H12 84.16 CCC=C(C)C 4050-45-7 (2E)-2-HEXEN C6H12 84.16 CCCC=CC 674-76-0 (2E)-4-METHYL-2-PENTEN C6H12 84.16 CC(C)C=CC 13269-52-8 (3E)-3-HEXEN C6H12 84.16 CCC=CCC 2415-72-7 PROPYLCYCLOPROPAN C6H12 84.16 CCCC1CC1 3638-35-5 1-ISOPROPYLCYCLOPROPAN C6H12 84.16 CC(C)C1CC1 53778-43-1 1-ETHYL-1-METHYL-CYCLOPROPAN C6H12 84.16 CCC1(C)CC1

Page 9 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 4127-45-1 1,1,2-TRIMETHYLCYCLOPROPAN C6H12 84.16 CC1CC1(C)C 4806-61-5 ETHYLCYCLOBUTAN C6H12 84.16 CCC1CCC1 96-37-7 METHYLCYCLOPENTAN C6H12 84.16 CC1CCCC1 110-82-7 CYCLOHEXAN C6H12 84.16 C1CCCCC1 75-09-2 DICHLORMETHAN CH2Cl2 84.93 ClCCl 1113-30-0 (DIMETHYLAMINO)-DIMETHYLBORIN C4H12BN 84.96 CB(C)N(C)C 372-09-8 cyanoaceticacid C3H3NO2 85.06 OC(CC#N)=O 3775-60-8 2-amino-1,3,4-oxadiazole C2H3N3O 85.06 Nc1ocnn1 5378-49-4 1h-tetrazol-1-amine CH3N5 85.07 Nc1[nH]nnn1 75-86-5 2-HYDROXY-2-CYANOPROPAN C4H7NO 85.10 OC(C)(C)C#N 110-67-8 3-METHOXYPROPIONITRIL C4H7NO 85.10 COCCC#N 1120-64-5 2-METHYL-4,5-DIHYDRO-1,3-OXAZOLE C4H7NO 85.10 CC1=NCCO1 616-45-5 2-PYRROLIDON C4H7NO 85.10 O=C1NCCC1 31110-30-2 ISOCROTONAMID C4H7NO 85.10 CC=CC(=O)N 79-39-0 METHACRYLSAEUREAMID C4H7NO 85.10 CC(=C)C(=O)N 6228-73-5 CYCLOPROPANECARBOXAMIDE C4H7NO 85.10 O=C(C1CC1)N 625-37-6 trans-crotonamide C4H7NO 85.10 CC=CC(=O)N 110-78-1 1-ISOCYANATOPROPAN C4H7NO 85.10 CCCN=C=O 1795-48-8 ISOPROPYLISOCYANAT C4H7NO 85.10 CC(C)N=C=O 288-47-1 THIAZOL C3H3NS 85.13 n1cscc1 2424-02-4 N-ETHYL-2-PROPEN-1-AMIN C5H11N 85.15 CCNCC=C 110-89-4 PIPERIDIN C5H11N 85.15 N1CCCCC1 120-94-5 1-METHYLPYRROLIDIN C5H11N 85.15 CN1CCCC1 1003-03-8 CYCLOPENTANAMIN C5H11N 85.15 NC1CCCC1 7783-42-8 THIONYLFLUORID F2OS 86.06 FS(F)=O 108-05-4 ESSIGSAEUREETHENYLESTER C4H6O2 86.09 CC(OC=C)=O 79-41-4 2-METHYL-2-PROPENSAEURE C4H6O2 86.09 OC(=O)C(C)=C 543-75-9 2,3-DIHYDRO-1,4-DIOXIN C4H6O2 86.09 C1OC=COC1 503-64-0 (2Z)-2-BUTENSAEURE C4H6O2 86.09 CC=CC(O)=O 1759-53-1 CYCLOPROPANCARBONSAEURE C4H6O2 86.09 OC(C1CC1)=O 1838-59-1 AMEISENSAEURE-2-PROPENYLESTER C4H6O2 86.09 O=COCC=C 107-93-7 (2E)-2-BUTENSAEURE C4H6O2 86.09 CC=CC(O)=O 431-03-8 2,3-BUTANDION C4H6O2 86.09 CC(=O)C(C)=O 4549-40-0 n-nitrosomethylvinylamine C3H6N2O 86.09 CN(N=O)C=C 96-33-3 2-PROPENSAEUREMETHYLESTER C4H6O2 86.09 COC(=O)C=C 625-38-7 3-BUTENSAEURE C4H6O2 86.09 OC(CC=C)=O 1464-53-5 1,3-BUTADIENDIEPOXID C4H6O2 86.09 C2OC2C1OC1 3068-88-0 4-methyl-2-oxetanone C4H6O2 86.09 CC1CC(O1)=O 30419-67-1 1,2:3,4-diepoxybutane(2r,3r) C4H6O2 86.09 C2OC2C1OC1 30031-64-2 1,2:3,4-diepoxybutane(2s,3s) C4H6O2 86.09 C1OC1C2OC2 298-18-0 1,2:3,4-diepoxybutanedl C4H6O2 86.09 C2OC2C1OC1 564-00-1 1,2:3,4-diepoxybutane C4H6O2 86.09 C2OC2C1OC1 96-48-0 DIHYDRO-2(3H)-FURANON C4H6O2 86.09 O=C1CCCO1 120-93-4 N,N`-ETHYLENHARNSTOFF C3H6N2O 86.09 O=C1NCCN1 110-65-6 2-BUTIN-1,4-DIOL C4H6O2 86.09 OCC#CCO 288-48-2 1,2,3-thiadiazole C2H2N2S 86.12 n1nscc1 96-41-3 CYCLOPENTANOL C5H10O 86.13 OC1CCCC1 926-65-8 2-(ETHENYLOXY)PROPAN C5H10O 86.13 CC(C)OC=C 616-25-1 1-PENTEN-3-OL C5H10O 86.13 CCC(O)C=C 10473-14-0 3-METHYL-3-BUTEN-2-OL C5H10O 86.13 OC(C)C(C)=C 1576-96-1 2-penten-1-ol,(e)- C5H10O 86.13 OCC=CCC 1576-95-0 2-penten-1-ol,(z)- C5H10O 86.13 OCC=CCC 115-18-4 2-METHYL-3-BUTEN-2-OL C5H10O 86.13 OC(C)(C)C=C 1569-50-2 3-PENTEN-2-OL C5H10O 86.13 OC(C)C=CC 821-09-0 4-PENTEN-1-OL C5H10O 86.13 OCCCC=C 557-31-3 3-ETHOXY-1-PROPEN C5H10O 86.13 CCOCC=C 5614-38-0 cyclopropane,ethoxy- C5H10O 86.13 CCOC1CC1 765-42-4 1-CYCLOPROPYLETHANOL C5H10O 86.13 OC(C)C1CC1 556-82-1 3-METHYL-2-BUTEN-1-OL C5H10O 86.13 OCC=C(C)C 630-19-3 2,2-DIMETHYLPROPANAL C5H10O 86.13 CC(C)(C)C=O 763-32-6 3-METHYL-3-BUTEN-1-OL C5H10O 86.13 OCCC(C)=C 22418-49-1 3-METHOXY-2-METHYL-1-PROPEN C5H10O 86.13 COCC(C)=C

Page 10 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 625-31-0 4-PENTEN-2-OL C5H10O 86.13 OC(C)CC=C 96-17-3 2-METHYLBUTANAL C5H10O 86.13 CCC(C)C=O 590-86-3 3-METHYLBUTANAL C5H10O 86.13 CC(C)CC=O 110-62-3 PENTANAL C5H10O 86.13 CCCCC=O 96-22-0 3-PENTANON C5H10O 86.13 CCC(CC)=O 563-80-4 3-METHYL-2-BUTANON C5H10O 86.13 CC(C)C(C)=O 142-68-7 TETRAHYDROPYRAN C5H10O 86.13 O1CCCCC1 107-87-9 2-PENTANON C5H10O 86.13 CCCC(C)=O 6921-35-3 2,2-DIMETHYL-1,3-PROPANOXID C5H10O 86.13 CC1(C)COC1 96-47-9 TETRAHYDRO-2-METHYLFURAN C5H10O 86.13 CC1CCCO1 13423-15-9 TETRAHYDRO-3-METHYLFURAN C5H10O 86.13 CC1CCOC1 764-47-6 PROPYLVINYLETHER C5H10O 86.13 CCCOC=C 110-85-0 PIPERAZIN C4H10N2 86.14 C1NCCNC1 1708-32-3 2,5-DIHYDROTHIOPHEN C4H6S 86.16 S1CC=CC1 1120-59-8 2,3-DIHYDROTHIOPHEN C4H6S 86.16 C1SC=CC1 627-51-0 3-THIA-1,4-PENTADIEN C4H6S 86.16 C=CSC=C 75-83-2 2,2-DIMETHYLBUTAN C6H14 86.18 CCC(C)(C)C 79-29-8 2,3-DIMETHYLBUTAN C6H14 86.18 CC(C)C(C)C 96-14-0 3-METHYLPENTAN C6H14 86.18 CCC(C)CC 107-83-5 2-METHYLPENTAN C6H14 86.18 CCCC(C)C 110-54-3 HEXAN C6H14 86.18 CCCCCC 75-45-6 CHLORDIFLUORMETHAN CHClF2 86.47 FC(F)Cl 7791-21-1 DICHLORMONOXID Cl2O 86.91 ClOCl 625-46-7 3-nitropropene C3H5NO2 87.08 C=CCN(=O)=O 306-44-5 hydroxyiminoacetone C3H5NO2 87.08 ON=CC(C)=O 96-29-7 2-BUTANONOXIM C4H9NO 87.12 CCC(C)=NO 110-69-0 BUTYRALDOXIM C4H9NO 87.12 CCCC=NO 1072-52-2 1-aziridineethanol C4H9NO 87.12 OCCN1CC1 127-19-5 N,N-DIMETHYLACETAMID C4H9NO 87.12 CN(C)C(C)=O 110-91-8 MORPHOLIN C4H9NO 87.12 O1CCNCC1 1187-58-2 N-METHYLPROPANAMID C4H9NO 87.12 CCC(=O)NC 625-50-3 ETHYL-N-ACETAMID C4H9NO 87.12 CCNC(C)=O 3324-71-8 dimethylguanidine C3H9N3 87.12 CN(C)C(=N)N 563-83-7 2-METHYLPROPIONSAEUREAMID C4H9NO 87.12 CC(C)C(=O)N 541-35-5 BUTANAMID C4H9NO 87.12 CCCC(=O)N 542-85-8 ISOTHIOCYANATOETHAN C3H5NS 87.14 CCN=C=S 542-90-5 THIOCYANSAEUREETHYLESTER C3H5NS 87.14 CCSC#N 616-39-7 N,N-DIETHYLMETHYLAMIN C5H13N 87.16 CCN(C)CC 926-63-6 N,N-DIMETHYLAMINOPROPAN C5H13N 87.16 CCCN(C)C 20193-20-8 ETHYLPROPYLAMIN C5H13N 87.16 CCNCCC 110-68-9 N-METHYL-1-BUTANAMIN C5H13N 87.16 CNCCCC 19961-27-4 N-ETHYL-2-PROPANAMIN C5H13N 87.16 CCNC(C)C 616-24-0 3-PENTANAMIN C5H13N 87.16 CCC(N)CC 625-30-9 2-AMINOPENTAN C5H13N 87.16 CCCC(N)C 598-74-3 1,2-DIMETHYLPROPYLAMIN C5H13N 87.16 NC(C)C(C)C 5813-64-9 2,2-DIMETHYL-1-PROPANAMIN C5H13N 87.16 NCC(C)(C)C 107-85-7 1-AMINO-3-METHYLBUTAN C5H13N 87.16 NCCC(C)C 110-58-7 1-PENTANAMIN C5H13N 87.16 NCCCCC 594-39-8 2-AMINO-2-METHYLBUTAN C5H13N 87.16 CCC(N)(C)C 920-37-6 2-propenenitrile,2-chloro- C3H2ClN 87.51 ClC(=C)C#N 17745-45-8 boronicacid,propyl- C3H9BO2 87.91 CCCB(O)O 7783-55-3 TRIFLUOROPHOSPHIN F3P 87.97 FP(F)F 19163-05-4 DIMETHYL-(METHYLTHIO)-BORAN_(3) C3H9BS 87.98 CSB(C)C 75-73-0 TETRAFLUORMETHAN CF4 88.00 FC(F)(F)F 127-17-3 2-OXOPROPANSAEURE C3H4O3 88.06 OC(=O)C(C)=O 96-49-1 1,3-DIOXOLAN-2-ON C3H4O3 88.06 O=C1OCCO1 557-30-2 ethanedial,dioxime C2H4N2O2 88.07 ON=CC=NO 674-81-7 nitrosoguanidine CH4N4O 88.07 O=NNC(=N)N 471-46-5 ETHANDIAMIDE C2H4N2O2 88.07 O=C(N)C(=O)N 628-36-4 N,N`-DIFORMYLHYDRAZIN C2H4N2O2 88.07 O=CNNC=O 79-31-2 2-METHYLPROPANSAEURE C4H8O2 88.11 CC(C)C(O)=O 107-92-6 BUTANSAEURE C4H8O2 88.11 CCCC(O)=O

Page 11 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 110-74-7 AMEISENSAEUREPROPYLESTER C4H8O2 88.11 CCCOC=O 50317-11-8 1,2-dihydroxy-2-butene C4H8O2 88.11 OCC(O)=CC 625-55-8 AMEISENSAEURE-1-METHYLETHYLESTER C4H8O2 88.11 CC(C)OC=O 554-12-1 PROPANSAEUREMETHYLESTER C4H8O2 88.11 COC(CC)=O 497-06-3 1-BUTEN-3,4-DIOL C4H8O2 88.11 OCC(O)C=C 764-48-7 ETHYLENGLYKOLMONOVINYLETHER C4H8O2 88.11 OCCOC=C 141-78-6 ESSIGSAEUREETHYLESTER C4H8O2 88.11 CCOC(C)=O 497-26-7 2-METHYL-1,3-DIOXOLAN C4H8O2 88.11 CC1OCCO1 930-37-0 (METHOXYMETHYL)OXIRAN C4H8O2 88.11 COCC1OC1 38433-80-6 PROPANAL,3-HYDROXY-2-METHYL C4H8O2 88.11 OCC(C)C=O 6117-80-2 (2Z)-2-BUTEN-1,4-DIOL C4H8O2 88.11 OCC=CCO 5077-67-8 1-HYDROXY-2-BUTANON C4H8O2 88.11 OCC(CC)=O 513-86-0 3-HYDROXY-2-BUTANON C4H8O2 88.11 OC(C)C(C)=O 505-22-6 1,3-DIOXAN C4H8O2 88.11 C1OCCCO1 453-20-3 3-furanol,tetrahydro- C4H8O2 88.11 OC1CCOC1 123-91-1 1,4-DIOXAN C4H8O2 88.11 C1OCCOC1 22056-82-2 ETHOXYACETALDEHYD C4H8O2 88.11 CCOCC=O 107-89-1 3-HYDROXYBUTYRALDEHYD C4H8O2 88.11 OC(C)CC=O 10595-95-6 n-methyl-n-nitrosoethamine C3H8N2O 88.11 CCN(C)N=O 5878-19-3 1-METHOXY-2-PROPANON C4H8O2 88.11 COCC(C)=O 110-64-5 2-BUTEN-1,4-DIOL C4H8O2 88.11 OCC=CCO 590-90-9 4-HYDROXY-2-BUTANON C4H8O2 88.11 OCCC(C)=O 25714-71-0 BUTANAL,4-HYDROXY- C4H8O2 88.11 OCCCC=O 24535-11-3 propionicacidhydrazide C3H8N2O 88.11 CCC(=O)NN 598-94-7 N,N-DIMETHYLHARNSTOFF C3H8N2O 88.11 CN(C)C(=O)N 96-31-1 N,N`-DIMETHYLHARNSTOFF C3H8N2O 88.11 CNC(=O)NC 821-11-4 (2E)-2-BUTEN-1,4-DIOL C4H8O2 88.11 OCC=CCO 625-52-5 ETHYLHARNSTOFF C3H8N2O 88.11 CCNC(=O)N 584-02-1 3-PENTANOL C5H12O 88.15 CCC(O)CC 598-75-4 3-METHYL-2-BUTANOL C5H12O 88.15 OC(C)C(C)C 137-32-6 2-METHYL-1-BUTANOL C5H12O 88.15 OCC(C)CC 75-85-4 2-METHYL-2-BUTANOL C5H12O 88.15 CCC(O)(C)C 71-41-0 1-PENTANOL C5H12O 88.15 OCCCCC 123-51-3 3-METHYL-1-BUTANOL C5H12O 88.15 OCCC(C)C 75-84-3 2,2-DIMETHYL-1-PROPANOL C5H12O 88.15 OCC(C)(C)C 6032-29-7 2-PENTANOL C5H12O 88.15 CCCC(O)C 625-44-5 METHYLISOBUTYLETHER C5H12O 88.15 COCC(C)C 628-32-0 1-ETHOXYPROPAN C5H12O 88.15 CCOCCC 628-28-4 1-METHOXYBUTAN C5H12O 88.15 COCCCC 6795-87-5 METHYL-SEK.-BUTYLETHER C5H12O 88.15 COC(C)CC 625-54-7 2-ETHOXYPROPAN C5H12O 88.15 CCOC(C)C 1634-04-4 METHYL-TERT.-BUTYLETHER C5H12O 88.15 COC(C)(C)C 6415-12-9 TETRAMETHYLHYDRAZIN C4H12N2 88.15 CN(C)N(C)C 616-40-0 1,1-DIETHYLHYDRAZIN C4H12N2 88.15 CCN(CC)N 1615-80-1 n,n'-diethylhydrazine C4H12N2 88.15 CCNNCC 110-70-3 1,2-ethanediamine,n,n'-dimethyl- C4H12N2 88.15 CNCCNC 110-72-5 N-ETHYL-1,2-DIAMINOETHAN C4H12N2 88.15 NCCNCC 110-60-1 1,4-BUTANDIAMIN C4H12N2 88.15 NCCCCN 110-01-0 TETRAHYDROTHIOPHEN C4H8S 88.17 C1CSCC1 10152-76-8 1-propene,3-(methylthio)- C4H8S 88.17 CSCC=C 17837-41-1 2-METHYLTHIACYCLOBUTAN C4H8S 88.17 CC1SCC1 75-76-3 TETRAMETHYLSILAN C4H12Si 88.22 C[Si](C)(C)C 542-91-6 DIETHYLSILAN C4H12Si 88.22 CC[SiH2]CC 21020-24-6 3-chloro-1-butyne C4H5Cl 88.54 CC(Cl)C#C 51908-64-6 4-chloro-1-butyne C4H5Cl 88.54 ClCCC#C 25790-55-0 4-CHLOR-1,2-BUTADIEN C4H5Cl 88.54 ClCC=C=C 627-22-5 1-CHLOR-1,3-BUTADIEN C4H5Cl 88.54 ClC=CC=C 627-23-6 1-chloro-1,2-butadiene C4H5Cl 88.54 CC=C=CCl 126-99-8 2-CHLOR-1,3-BUTADIEN C4H5Cl 88.54 ClC(=C)C=C 34581-41-4 3-chloro-1,2-butadiene C4H5Cl 88.54 CC(Cl)=C=C 62981-74-2 1-chloro-1-butyne C4H5Cl 88.54 CCC#CCl 471-47-6 OXALSAEUREMONOAMID C2H3NO3 89.05 OC(=O)C(=O)N

Page 12 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 79-46-9 2-NITROPROPAN C3H7NO2 89.09 CC(C)N(=O)=O 108-03-2 1-NITROPROPAN C3H7NO2 89.09 CCCN(=O)=O 6642-30-4 METHYLCARBAMIDSAEUREMETHYLESTER C3H7NO2 89.09 COC(=O)NC 51-79-6 CARBAMIDSAEUREETHYLESTER C3H7NO2 89.09 CCOC(=O)N 541-42-4 ISOPROPYLNITRIT C3H7NO2 89.09 CC(C)ON=O 543-67-9 PROPYLNITRIT C3H7NO2 89.09 CCCON=O 625-51-4 formicin C3H7NO2 89.09 OCNC(C)=O 2043-43-8 2-HYDROXYPROPANAMID C3H7NO2 89.09 OC(C)C(=O)N 107-97-1 N-METHYLGLYCIN C3H7NO2 89.09 C[NH2+]CC([O-])=O 107-95-9 BETA-ALANIN C3H7NO2 89.09 [NH3+]CCC([O-])=O 56-41-7 ALANIN C3H7NO2 89.09 CC([NH3+])C([O-])=O 17696-95-6 4-methylsemicarbazide C2H7N3O 89.10 CNC(=O)NN 4418-61-5 1H-TETRAZOL-5-AMIN CH7N5 89.10 NC1NNNN1 3710-84-7 N,N-DIETHYLHYDROXYLAMIN C4H11NO 89.14 CCN(O)CC 110-73-6 2-(ETHYLAMINO)-ETHANOL C4H11NO 89.14 OCCNCC 108-01-0 N,N-DIMETHYLETHANOLAMIN C4H11NO 89.14 OCCN(C)C 124-68-5 2-AMINO-2-METHYL-1-PROPANOL C4H11NO 89.14 OCC(N)(C)C 96-20-8 2-AMINO-1-BUTANOL C4H11NO 89.14 OCC(N)CC 2854-16-2 1-AMINO-2-METHYL-2-PROPANOL C4H11NO 89.14 NCC(O)(C)C 37143-54-7 2-PROPANAMINE,1-METHOXY- C4H11NO 89.14 COCC(N)C 110-76-9 2-ETHOXYETHYLAMIN C4H11NO 89.14 CCOCCN 70807-90-8 2-methoxy-1propanamine C4H11NO 89.14 COC(C)CN 5332-73-0 3-METHOXY-1-PROPANAMIN C4H11NO 89.14 COCCCN 758-16-7 N,N-DIMETHYLMETHANTHIOAMID C3H7NS 89.16 CN(C)C=S 542-76-7 1-CHLORO-2-CYANOETHAN C3H4ClN 89.52 ClCCC#N 1617-17-0 2-CHLORPROPANSAEURENITRIL C3H4ClN 89.52 ClCCC#N 144-62-7 ETHANDISAEURE C2H2O4 90.04 OC(=O)C(O)=O 616-38-6 KOHLENSAEUREDIMETHYLESTER C3H6O3 90.08 COC(OC)=O 110-88-3 1,3,5-TRIOXAN C3H6O3 90.08 C1OCOCO1 4164-28-7 N-METHYL-N-NITROMETHANAMIN C2H6N2O2 90.08 CN(C)N(=O)=O 96-35-5 GLYKOLSAEUREMETHYLESTER C3H6O3 90.08 COC(CO)=O 625-45-6 METHOXYESSIGSAEURE C3H6O3 90.08 COCC(O)=O 6294-89-9 hydrazinecarboxylicacid,methylester C2H6N2O2 90.08 COC(=O)NN 497-18-7 carbonicdihydrazide CH6N4O 90.08 NNC(=O)NN 50-21-5 2-HYDROXYPROPANSAEURE C3H6O3 90.08 OC(C)C(O)=O 56-82-6 propanal,2,3-dihydroxy-,(r)- C3H6O3 90.08 OCC(O)C=O 367-47-5 glyceraldehyde C3H6O3 90.08 OCC(O)C=O 503-66-2 hydracrylicacid C3H6O3 90.08 OCCC(O)=O 96-26-4 dihydroxyacetone C3H6O3 90.08 OCC(CO)=O 7433-43-4 1-methylhydroxyurea C2H6N2O2 90.08 ON(C)C(=O)N 1000-82-4 hydroxymethylurea C2H6N2O2 90.08 OCNC(=O)N 2501-94-2 tert-butylphosphine C4H11P 90.10 CC(C)(C)P 628-37-5 DIETHYLPEROXID C4H10O2 90.12 CCOOCC 75-91-2 1,1-DIMETHYLETHYLHYDROPEROXID C4H10O2 90.12 OOC(C)(C)C 4813-50-7 HYDROPEROXIDE,BUTYL C4H10O2 90.12 OOCCCC 558-43-0 2-METHYL-1,2-PROPANDIOL C4H10O2 90.12 OCC(O)(C)C 5341-95-7 (2R,3S)-REL-2,3-BUTANDIOL C4H10O2 90.12 OC(C)C(O)C 6982-25-8 DL-2,3-BUTANDIOL C4H10O2 90.12 OC(C)C(O)C 584-03-2 1,2-BUTANDIOL C4H10O2 90.12 OCC(O)CC 2163-42-0 2-METHYL-1,3-PROPANDIOL C4H10O2 90.12 OCC(C)CO 107-88-0 1,3-BUTANDIOL C4H10O2 90.12 OCCC(O)C 110-80-5 2-ETHOXYETHANOL C4H10O2 90.12 OCCOCC 107-98-2 1-METHOXY-PROPAN-2-OL C4H10O2 90.12 COCC(O)C 110-63-4 1,4-BUTANDIOL C4H10O2 90.12 OCCCCO 534-15-6 1,1-DIMETHOXYETHAN C4H10O2 90.12 COC(C)OC 1589-47-5 2-METHOXY-1-PROPANOL C4H10O2 90.12 COC(C)CO 110-71-4 1,2-DIMETHOXYETHAN C4H10O2 90.12 COCCOC 24653-75-6 1-sulfanylpropan-2-one C3H6OS 90.14 SCC(C)=O 13153-11-2 thietane,1-oxide C3H6OS 90.14 O=S1CCC1 592-50-7 1-FLUORPENTAN C5H11F 90.14 FCCCCC 598-52-7 N-METHYLTHIOHARNSTOFF C2H6N2S 90.15 CNC(N)=S 352-93-2 DIETHYLTHIOETHER C4H10S 90.19 CCSCC

Page 13 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 1551-21-9 ISOPROPYLMETHYLSULFID C4H10S 90.19 CSC(C)C 3877-15-4 1-(METHYLTHIO)PROPAN C4H10S 90.19 CCCSC 75-66-1 TERT.-BUTYLMERCAPTAN C4H10S 90.19 CC(C)(C)S 109-79-5 1-BUTANTHIOL C4H10S 90.19 CCCCS 513-44-0 2-METHYL-1-PROPANTHIOL C4H10S 90.19 SCC(C)C 513-53-1 2-BUTANTHIOL C4H10S 90.19 CCC(C)S 1066-40-6 TRIMETHYLSILICIUMHYDROXID C3H10OSi 90.20 O[Si](C)(C)C 814-68-6 2-PROPENOYLCHLORID C3H3ClO 90.51 ClC(=O)C=C 4628-21-1 (2Z)-1-CHLOR-2-BUTEN C4H7Cl 90.55 ClCC=CC 591-97-9 1-chloro-2-butene C4H7Cl 90.55 ClCC=CC 4894-61-5 (2E)-1-CHLOR-2-BUTEN C4H7Cl 90.55 ClCC=CC 5911-08-0 chloromethyl-cyclopropane C4H7Cl 90.55 ClCC1CC1 927-73-1 4-CHLOR-1-BUTEN C4H7Cl 90.55 ClCCC=C 563-52-0 3-CHLOR-1-BUTEN C4H7Cl 90.55 CC(Cl)C=C 563-47-3 3-CHLOR-2-METHYL-1-PROPEN C4H7Cl 90.55 ClCC(C)=C 4461-42-1 1-chloro-1-butene C4H7Cl 90.55 CCC=CCl 513-37-1 1-CHLOR-2-METHYL-1-PROPEN C4H7Cl 90.55 ClC=C(C)C 2211-70-3 2-CHLOR-1-BUTEN C4H7Cl 90.55 CCC(Cl)=C 625-58-1 SALPETERSAEUREETHYLESTER C2H5NO3 91.07 CCON(=O)=O 625-48-9 2-NITROETHANOL C2H5NO3 91.07 OCCN(=O)=O 367-49-7 a-fluoro-n-methylacetamide C3H6FNO 91.08 FCC(=O)NC 79-19-6 HYDRAZINCARBOTHIOAMID CH5N3S 91.14 NNC(N)=S 593-52-2 METHYLARSIN CH5As 91.97 C[AsH2] 10544-72-6 DISTICKSTOFFTETROXID N2O4 92.01 0.00 453-18-9 METHYLFLUORACETAT C3H5FO2 92.07 FCC(OC)=O 56-81-5 1,2,3-PROPANTRIOL C3H8O3 92.09 OCC(O)CO 4513-94-4 2-cyanopyrrole C5H4N2 92.10 N#Cc1[nH]ccc1 68-11-1 MERCAPTOACETICACID C2H4O2S 92.12 SCC(O)=O 2396-63-6 1,6-HEPTADIIN C7H8 92.14 C#CCCCC#C 544-25-2 1,3,5,7-CYCLOHEPTATRIEN C7H8 92.14 C1C=CC=CC=C1 108-88-3 TOLUOL C7H8 92.14 Cc1ccccc1 121-46-0 NORBORNADIEN C7H8 92.14 C1C2C=CC1C=C2 278-06-8 TETRACYCLO(3.2.0.0(2,7).0(4,6))HEPTANE C7H8 92.14 C4C1C3C1C2C3C42 19721-22-3 3-MERCAPTOPROPANOL C3H8OS 92.16 OCCCS 5271-38-5 2-(METHYLTHIO)ETHANOL C3H8OS 92.16 OCCSC 1066-42-8 dimethyl-dihydroxysilane C2H8O2Si 92.17 O[Si](O)(C)C 7790-91-2 CHLORFLUORID(CLF3) ClF3 92.45 0.00 1184-58-3 DIMETHYLALUMINIUMCHLORID C2H6AlCl 92.50 C[Al](C)Cl 106-89-8 (CHLORMETHYL)OXIRAN C3H5ClO 92.52 ClCC1OC1 78-95-5 1-CHLOR-2-PROPANON C3H5ClO 92.52 ClCC(C)=O 79-03-8 PROPANOYLCHLORID C3H5ClO 92.52 CCC(Cl)=O 507-20-0 2-CHLOR-2-METHYLPROPAN C4H9Cl 92.57 CC(C)(C)Cl 78-86-4 2-CHLORBUTAN C4H9Cl 92.57 CCC(C)Cl 109-69-3 1-BUTYLCHLORID C4H9Cl 92.57 CCCCCl 513-36-0 1-CHLOR-2-METHYLPROPAN C4H9Cl 92.57 ClCC(C)C 617-90-3 FURAN-2-CARBONSAEURENITRIL C5H3NO 93.08 N#Cc1occc1 31108-57-3 4-cyanopyrazole C4H3N3 93.09 N#Cc1c[nH]nc1 62-53-3 ANILIN C6H7N 93.13 Nc1ccccc1 109-06-8 2-METHYLPYRIDIN C6H7N 93.13 Cc1ccccn1 108-99-6 3-METHYLPYRIDIN C6H7N 93.13 Cc1cccnc1 108-89-4 4-METHYLPYRIDIN C6H7N 93.13 Cc1ccncc1 79-07-2 2-CHLORACETAMID C2H4ClNO 93.51 ClCC(=O)N 26245-56-7 n-chloro-2-propanamine C3H8ClN 93.56 ClNC(C)C 359-40-0 OXALYLDIFLUORID C2F2O2 94.02 FC(=O)C(F)=O 3283-12-3 DIMETHYLPHOSPHINSAEURE C2H7O2P 94.05 OP(C)(C)=O 17088-73-2 BIS-(HYDROXYMETHYL)-PEROXID C2H6O4 94.07 OCOOCO 1487-18-9 2-ETHENYLFURAN C6H6O 94.11 C=Cc1occc1 108-95-2 PHENOL C6H6O 94.11 Oc1ccccc1 504-29-0 2-PYRIDINAMIN C5H6N2 94.12 Nc1ccccn1 5053-43-0 pyrimidine,2-methyl- C5H6N2 94.12 Cc1ncccn1 109-08-0 2-METHYLPYRAZIN C5H6N2 94.12 Cc1cnccn1 7321-55-3 DIMETHYLMALONONITRIL C5H6N2 94.12 CC(C)(C#N)C#N

Page 14 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 2036-41-1 pyrimidine,5-methyl- C5H6N2 94.12 Cc1cncnc1 3438-46-8 4-methylpyrimidine C5H6N2 94.12 Cc1ccncn1 1120-88-3 pyridazine,4-methyl- C5H6N2 94.12 Cc1ccnnc1 1632-76-4 pyridazine,3-methyl- C5H6N2 94.12 Cc1cccnn1 462-08-8 3-PYRIDINAMIN C5H6N2 94.12 Nc1cccnc1 504-24-5 4-PYRIDINAMIN C5H6N2 94.12 Nc1ccncc1 544-13-8 GLUTARSAEUREDINITRIL C5H6N2 94.12 N#CCCCC#N 67-71-0 SULFONYLBISMETHAN C2H6O2S 94.13 CS(C)(=O)=O 2384-73-8 1-hepten-3-yne C7H10 94.15 CCCC#CC=C 4054-38-0 1,3-CYCLOHEPTADIEN C7H10 94.15 C1CC=CC=CC1 1489-57-2 1,3-cyclohexadiene,2-methyl- C7H10 94.15 CC1=CCCC=C1 187-26-8 TRICYCLO[4.1.0.0(2,4)]HEPTAN C7H10 94.15 C3C1CC1C2CC32 16554-83-9 3-NORCARAN C7H10 94.15 C(C21)C1CC=CC2 498-66-8 BICYCLO(2.2.1)HEPT-2-EN C7H10 94.15 C(C2)C1C=CC2C1 287-13-8 tricyclo(4.1.0.02,7)heptane C7H10 94.15 C3CC1C2C1C2C3 279-19-6 TRICYCLO(2,2,1,0)HEPTAN C7H10 94.15 C2C1C3C1CC2C3 29414-47-9 (METHYLTHIO)METHANTHIOL C2H6S2 94.20 CSCS 540-63-6 1,2-ETHANDITHIOL C2H6S2 94.20 SCCS 624-92-0 DIMETHYLDISULFID C2H6S2 94.20 CSSC 79-22-1 CHLORAMEISENSAEUREMETHYLESTER C2H3ClO2 94.50 COC(Cl)=O 79-11-8 CHLORESSIGSAEURE C2H3ClO2 94.50 ClCC(O)=O 3135-74-8 urea,chloro- CH3ClN2O 94.50 ClNC(=O)N 3188-13-4 (CHLORMETHOXY)ETHANE C3H7ClO 94.54 CCOCCl 78-89-7 PROPYLENCHLORHYDRIN C3H7ClO 94.54 OCC(C)Cl 627-30-5 3-CHLOR-1-PROPANOL C3H7ClO 94.54 OCCCCl 127-00-4 1-CHLOR-2-PROPANOL C3H7ClO 94.54 ClCC(O)C 627-42-9 (2-CHLORETHYL)-METHYLETHER C3H7ClO 94.54 COCCCl 1066-35-9 CHLORDIMETHYLSILAN C2H7ClSi 94.62 C[SiH](C)Cl 7572-29-4 dichloroacetylene C2Cl2 94.93 ClC#CCl 74-83-9 BROMMETHAN CH3Br 94.94 CBr 353-85-5 TRIFLUORACETONITRIL C2F3N 95.02 FC(F)(F)C#N 142-08-5 pyridole C5H5NO 95.10 Oc1ccccn1 626-64-2 4-PYRIDINOL C5H5NO 95.10 Oc1ccncc1 109-00-2 3-PYRIDINOL C5H5NO 95.10 Oc1cccnc1 109-12-6 2-PYRIMIDINAMIN C4H5N3 95.10 Nc1ncccn1 5469-70-5 2-aminopyrimidine C4H5N3 95.10 Nc1ncccn1 1003-29-8 pyrrole-2-carboxaldehyde C5H5NO 95.10 O=Cc1[nH]ccc1 24108-33-6 1,2,4-triazine,3-methyl- C4H5N3 95.10 Cc1nccnn1 5049-61-6 2-aminopyrazine C4H5N3 95.10 Nc1cnccn1 694-59-7 PYRIDIN-1-OXID C5H5NO 95.10 O=n1ccccc1 591-54-8 4-pyrimidinamine C4H5N3 95.10 Nc1ccncn1 72762-00-6 2-PYRIDINOL C5H5NO 95.10 O=C1NC=CC=C1 20744-39-2 4-pyridazinamine C4H5N3 95.10 Nc1ccnnc1 628-87-5 ACETONITRILE,2,2-IMINOBIS- C4H5N3 95.10 N#CCNCC#N 617-92-5 1-ETHYL-1H-PYRROL C6H9N 95.14 CCn1cccc1 625-84-3 2,5-DIMETHYL-1H-PYRROL C6H9N 95.14 Cc1[nH]c(C)cc1 625-82-1 2,4-DIMETHYL-1H-PYRROL C6H9N 95.14 Cc1cc(C)[nH]c1 1551-06-0 2-ETHYL-1H-PYRROL C6H9N 95.14 CCc1[nH]ccc1 1794-84-9 CHLORNITROMETHAN CH2ClNO2 95.49 ClCN(=O)=O 993-13-5 methylphosphonicacid CH5O3P 96.02 OP(O)(C)=O 381-73-7 DIFLUORESSIGSAEURE C2H2F2O2 96.03 FC(F)C(O)=O 677-21-4 3,3,3-TRIFLUORPROPEN C3H3F3 96.05 FC(F)(F)C=C 461-57-4 1,1-DIFLUOR-2-METHOXYETHAN C3H6F2O 96.08 COCC(F)F 453-13-4 1,3-difluoro-2-propanol C3H6F2O 96.08 FCC(O)CF 108-28-1 2(5h)-furanone,5-methylene- C5H4O2 96.08 O=C1C=CC(O1)=C 498-60-2 FURAN-3-ALDEHYD C5H4O2 96.08 O=Cc1cocc1 98-01-1 2-FURANCARBOXALDEHYD C5H4O2 96.08 O=Cc1occc1 504-31-4 2H-PYRAN-2-ON C5H4O2 96.08 O=C1C=CC=CO1 108-97-4 4H-PYRAN-4-ON C5H4O2 96.08 O=C1C=COC=C1 6270-63-9 pyrazine-2-one C4H4N2O 96.09 O=C1NC=CN=C1 51953-17-4 4(3h)-pyrimidone C4H4N2O 96.09 O=C1NC=NC=C1 557-01-7 2-pyrimidone C4H4N2O 96.09 O=C1NC=CC=N1

Page 15 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 4562-27-0 4-pyrimidone C4H4N2O 96.09 O=C1C=CNC=N1 462-06-6 FLUORBENZOL C6H5F 96.10 Fc1ccccc1 75-75-2 METHANSULFONSAEURE CH4O3S 96.11 OS(C)(=O)=O 105-29-3 1-HYDROXY-3-METHYL-2-PENTEN-4-IN C6H8O 96.13 OCC=C(C)C#C 2550-28-9 5-HEXYN-2-ONE C6H8O 96.13 CC(CCC#C)=O 67-51-6 3,5-DIMETHYLPYRAZOL C5H8N2 96.13 Cc1cc(C)[nH]n1 4096-34-8 cyclohex-3-enone C6H8O 96.13 O=C1CC=CCC1 142-83-6 2,4-hexadienal C6H8O 96.13 CC=CC=CC=O 1072-62-4 2-ETHYL-1H-IMIDAZOL C5H8N2 96.13 CCc1[nH]ccn1 1120-73-6 2-METHYL-2-CYCLOPENTEN-1-ON C6H8O 96.13 CC1=CCCC1=O 930-68-7 2-CYCLOHEXEN-1-ON C6H8O 96.13 O=C1C=CCCC1 2758-18-1 3-METHYL-2-CYCLOPENTEN-1-ON C6H8O 96.13 CC1=CC(CC1)=O 35520-41-3 3-dimethylaminoacrylonitrile C5H8N2 96.13 CN(C)C=CC#N 2721-32-6 2,3-DIAZABICYCLO[2.2.1]HEPT-2-EN C5H8N2 96.13 C1CC2N=NC1C2 7098-07-9 1-ETHYL-1H-IMIDAZOL C5H8N2 96.13 CCn1ccnc1 1739-84-0 1,2-DIMETHYL-1H-IMIDAZOL C5H8N2 96.13 Cc1nccn1C 3208-16-0 2-ETHYLFURAN C6H8O 96.13 CCc1occc1 625-86-5 2,5-DIMETHYLFURAN C6H8O 96.13 Cc1oc(C)cc1 3710-43-8 2,4-DIMETHYLFURAN C6H8O 96.13 Cc1cc(C)oc1 2203-80-7 5-METHYL-1-HEXIN C7H12 96.17 CC(C)CCC#C 628-71-7 1-HEPTIN C7H12 96.17 CCCCCC#C 1119-65-9 2-HEPTIN C7H12 96.17 CCCCC#CC 53566-37-3 5-METHYL-2-HEXIN C7H12 96.17 CC(C)CC#CC 2586-89-2 3-HEPTIN C7H12 96.17 CCCC#CCC 36566-80-0 2-METHYL-3-HEXIN C7H12 96.17 CCC#CC(C)C 4049-81-4 2-METHYL-1,5-HEXADIEN C7H12 96.17 CC(CCC=C)=C 3070-53-9 1,6-HEPTADIEN C7H12 96.17 C=CCCCC=C 28823-41-8 2-METHYL-2,4-HEXADIEN C7H12 96.17 CC=CC=C(C)C 1000-86-8 2,4-DIMETHYL-1,3-PENTADIEN C7H12 96.17 CC(C)=CC(C)=C 2384-90-9 1,2-heptadiene C7H12 96.17 CCCCC=C=C 1192-37-6 METHYLENCYCLOHEXAN C7H12 96.17 C=C1CCCCC1 591-47-9 4-METHYLCYCLOHEXEN C7H12 96.17 CC1CC=CCC1 591-48-0 3-METHYL-1-CYCLOHEXEN C7H12 96.17 CC1C=CCCC1 694-35-9 3-ETHYL-1-CYCLOPENTEN C7H12 96.17 CCC1C=CCC1 628-92-2 CYCLOHEPTEN C7H12 96.17 C1CCC=CCC1 2146-37-4 ETHYLIDENCYCLOPENTAN C7H12 96.17 CC=C1CCCC1 19037-72-0 4,4-DIMETHYLCYCLOPENTEN C7H12 96.17 CC1(C)CC=CC1 591-49-1 1-METHYLCYCLOHEXEN C7H12 96.17 CC1=CCCCC1 16491-15-9 2,3-DIMETHYLCYCLOPENTEN C7H12 96.17 CC1CCC=C1C 19550-48-2 1,4-DIMETHYLCYCLOPENTEN C7H12 96.17 CC1CC(C)=CC1 2146-38-5 1-ETHYLCYCLOPENTEN C7H12 96.17 CCC1=CCCC1 765-47-9 1,2-DIMETHYLCYCLOPENTEN C7H12 96.17 CC1=C(C)CCC1 286-08-8 BICYCLO(4.1.0)HEPTAN C7H12 96.17 C2CC1CC1CC2 279-23-2 BICYCLO(2.2.1)HEPTAN C7H12 96.17 C1CC2CC1CC2 138689-24-4 chlorofluoroacetaldehyde C2H2ClFO 96.49 FC(Cl)C=O 811-62-1 DIMETHYLPHOSPHORCHLORID C2H6ClP 96.50 CP(C)Cl 462-38-4 1-chloro-3-fluoropropane C3H6ClF 96.53 FCCCCl 2373-51-5 chloromethylmethylsulfide C2H5ClS 96.58 CSCCl 4325-97-7 2-CHLORETHANTHIOL C2H5ClS 96.58 ClCCS 156-59-2 (Z)-1,2-DICHLORETHEN C2H2Cl2 96.94 ClC=CCl 156-60-5 (E)-1,2-DICHLORETHEN C2H2Cl2 96.94 ClC=CCl 75-35-4 1,1-DICHLORETHEN C2H2Cl2 96.94 ClC(Cl)=C 541-59-3 1h-pyrrole-2,5-dione C4H3NO2 97.07 O=C1NC(=O)C=C1 372-48-5 2-fluoropyridine C5H4FN 97.09 Fc1ccccn1 372-47-4 3-fluoropyridine C5H4FN 97.09 Fc1cccnc1 5329-14-6 AMINOSCHWEFELSAEURE H3NO3S 97.09 OS(=O)(=O)N 54496-86-5 4-methyl-trans-crotonicacidnitrile C5H7NO 97.12 COCC=CC#N 300-87-8 isoxazole,3,5-dimethyl- C5H7NO 97.12 Cc1cc(C)on1 7208-05-1 oxazole,2,4-dimethyl- C5H7NO 97.12 Cc1nc(C)oc1 23012-11-5 2,5-dimethyl-oxazole C5H7NO 97.12 Cc1oc(C)cn1 617-89-0 2-FURANMETHANAMIN C5H7NO 97.12 NCc1occc1 5370-57-0 1h-pyrrole,2,3-dihydro-1,5-dimethyl- C6H11N 97.16 CN1CCC=C1C

Page 16 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 628-73-9 HEXANNITRIL C6H11N 97.16 CCCCCC#N 542-54-1 4-METHYLPENTANNITRIL C6H11N 97.16 CC(C)CCC#N 617-80-1 2-ETHYLBUTANNITRIL C6H11N 97.16 CCC(CC)C#N 124-02-7 N-2-PROPENYL-2-PROPEN-1-AMIN C6H11N 97.16 C=CCNCC=C 286-18-0 7-azabicyclo[4.1.0]heptane C6H11N 97.16 C2CC1NC1CC2 7664-38-2 PHOSPHORSAEURE H3O4P 98.00 OP(O)(O)=O 97-94-9 TRIETHYLBORAN C6H15B 98.00 CCB(CC)CC 75-90-1 TRIFLUORACETALDEHYD C2HF3O 98.02 FC(F)(F)C=O 108-31-6 2,5-FURANDION C4H2O3 98.06 O=C1C=CC(O1)=O 4949-13-7 2-fluoropyrazine C4H3FN2 98.08 Fc1cnccn1 675-21-8 pyrimidine,5-fluoro- C4H3FN2 98.08 Fc1cncnc1 31575-35-6 pyrimidine,2-fluoro- C4H3FN2 98.08 Fc1ncccn1 7664-93-9 SCHWEFELSAEURE H2O4S 98.08 OS(O)(=O)=O 25414-22-6 2-METHOXYFURAN C5H6O2 98.10 COc1occc1 623-47-2 PROPIOLSAEUREETHYLESTER C5H6O2 98.10 CCOC(=O)C#C 558-25-8 fluoromethylsulfone CH3FO2S 98.10 FS(C)(=O)=O 626-99-3 2,4-PENTADIENSAEURE C5H6O2 98.10 OC(=O)C=CC=C 98-00-0 2-FURANMETHANOL C5H6O2 98.10 OCc1occc1 4412-91-3 3-hydroxymethylfuran C5H6O2 98.10 OCc1cocc1 591-12-8 2(3h)-furanone,5-methyl- C5H6O2 98.10 CC(OC1=O)=CC1 4975-21-7 3,4-DIMETHYL-1,2,5-OXADIAZOL C4H6N2O 98.10 Cc1nonc1C 5729-47-5 4-oxo-2-pentenal C5H6O2 98.10 CC(=O)C=CC=O 547-65-9 alpha-methylenebutyrolactone C5H6O2 98.10 O=C1OCCC1=C 6089-09-4 4-PENTINSAEURE C5H6O2 98.10 OC(CCC#C)=O 591-11-7 5-METHYL-2(5H)-FURANON C5H6O2 98.10 CC1C=CC(O1)=O 1333-38-6 angelicalactone C5H6O2 98.10 CC1OC=CC1=O 10552-94-0 n-nitroso-3-pyrroline C4H6N2O 98.10 O=NN1CC=CC1 14884-01-6 4-methoxypyrazole C4H6N2O 98.10 COc1c[nH]nc1 1072-67-9 5-METHYL-3-ISOXAZOLAMIN C4H6N2O 98.10 Nc1cc(C)on1 4135-93-7 2,5-DIMETHYL-2H-TETRAZOL C3H6N4 98.11 Cc1nn(C)nn1 1609-07-0 1-methyl-2-cyanoguanidine C3H6N4 98.11 CNC(N)=NC#N 557-40-4 DIALLYLETHER C6H10O 98.14 C=CCOCC=C 822-66-2 3-CYCLOHEXENOL C6H10O 98.14 OC1CC=CCC1 109-50-2 3-hexyn-2-ol C6H10O 98.14 CCC#CC(O)C 822-67-3 2-CYCLOHEXEN-1-OL C6H10O 98.14 OC1C=CCCC1 924-41-4 1,5-hexadien-3-ol C6H10O 98.14 OC(CC=C)C=C 111-28-4 2,4-hexadien-1-ol C6H10O 98.14 OCC=CC=CC 77-75-8 3-METHYL-1-PENTIN-3-OL C6H10O 98.14 CCC(O)(C)C#C 1002-28-4 3-hexyn-1-ol C6H10O 98.14 OCCC#CCC 105-31-7 1-hexyn-3-ol C6H10O 98.14 CCCC(O)C#C 872-53-7 FORMYLCYCLOPENTAN C6H10O 98.14 O=CC1CCCC1 286-20-4 7-OXABICYCLO(4.1.0)HEPTAN C6H10O 98.14 C2CC1OC1CC2 6789-80-6 (z)-3-hexenal C6H10O 98.14 CCC=CCC=O 25044-01-3 2-methyl-1-penten-3-one C6H10O 98.14 CCC(=O)C(C)=C 16302-35-5 3,6-DIHYDRO-4-METHYL-2H-PYRAN C6H10O 98.14 CC1=CCOCC1 3744-02-3 4-METHYL-4-PENTEN-2-ON C6H10O 98.14 CC(CC(C)=C)=O 25659-22-7 4-hexen-2-one C6H10O 98.14 CC=CCC(C)=O 109-49-9 5-HEXEN-2-ON C6H10O 98.14 CC(CCC=C)=O 1120-72-5 2-METHYLCYCLOPENTANON C6H10O 98.14 CC1CCCC1=O 3019-25-8 cyclobutylmethylketone C6H10O 98.14 CC(C1CCC1)=O 623-36-9 2-METHYL-2-PENTENAL C6H10O 98.14 CCC=C(C)C=O 505-57-7 2-hexenal-tr C6H10O 98.14 CCCC=CC=O 2497-21-4 4-hexen-3-one C6H10O 98.14 CCC(=O)C=CC 141-79-7 4-METHYL-3-PENTEN-2-ON C6H10O 98.14 CC(C)=CC(C)=O 108-94-1 CYCLOHEXANON C6H10O 98.14 O=C1CCCCC1 763-93-9 3-HEXEN-2-ON C6H10O 98.14 CCC=CC(C)=O 1738-25-6 3-DIMETHYLAMINOPROPIONSAEURENITRIL C5H10N2 98.15 CN(C)CCC#N 617-83-4 DIETHYLCYANAMID C5H10N2 98.15 CCN(CC)C#N 616-44-4 3-METHYLTHIOPHEN C5H6S 98.17 Cc1cscc1 554-14-3 2-METHYLTHIOPHEN C5H6S 98.17 Cc1sccc1 6094-02-6 2-METHYL-1-HEXEN C7H14 98.19 CCCCC(C)=C 594-56-9 2,3,3-TRIMETHYL-1-BUTEN C7H14 98.19 CC(C)(C)C(C)=C

Page 17 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 3524-73-0 5-METHYL-1-HEXEN C7H14 98.19 CC(C)CCC=C 592-76-7 1-HEPTEN C7H14 98.19 CCCCCC=C 3404-72-6 2,3-DIMETHYL-1-PENTEN C7H14 98.19 CCC(C)C(C)=C 3404-73-7 3,3-DIMETHYL-1-PENTEN C7H14 98.19 CCC(C)(C)C=C 3404-71-5 2-ETHYL-1-PENTEN C7H14 98.19 CCCC(CC)=C 2213-32-3 2,4-DIMETHYL-1-PENTEN C7H14 98.19 CC(C)CC(C)=C 7357-93-9 2-METHYL-3-METHYLENPENTAN C7H14 98.19 CCC(C(C)C)=C 6443-92-1 (2Z)-2-HEPTEN C7H14 98.19 CCCCC=CC 762-62-9 4,4-DIMETHYL-1-PENTEN C7H14 98.19 CC(C)(C)CC=C 4038-04-4 3-ETHYL-1-PENTEN C7H14 98.19 CCC(CC)C=C 2738-19-4 2-METHYL-2-HEXEN C7H14 98.19 CCCC=C(C)C 17618-77-8 3-METHYL-2-HEXEN C7H14 98.19 CCCC(C)=CC 3404-61-3 3-METHYL-1-HEXEN C7H14 98.19 CCCC(C)C=C 7642-10-6 (3Z)-3-HEPTEN C7H14 98.19 CCCC=CCC 3769-23-1 4-METHYL-1-HEXEN C7H14 98.19 CCC(C)CC=C 10574-37-5 2,3-DIMETHYL-2-PENTEN C7H14 98.19 CCC(C)=C(C)C 10574-36-4 CIS-3-METHYL-2-HEXEN C7H14 98.19 CCCC(C)=CC 14686-13-6 (2E)-2-HEPTEN C7H14 98.19 CCCCC=CC 816-79-5 3-ETHYL-2-PENTEN C7H14 98.19 CCC(CC)=CC 625-65-0 2,4-DIMETHYL-2-PENTEN C7H14 98.19 CC(C)C=C(C)C 24910-63-2 3,4-DIMETHYL-2-PENTEN C7H14 98.19 CC(C)C(C)=CC 762-63-0 (2Z)-4,4-DIMETHYL-2-PENTEN C7H14 98.19 CC(C)(C)C=CC 4914-92-5 TRANS-3,4-DIMETHYL-2-PENTEN C7H14 98.19 CC(C)C(C)=CC 3404-65-7 3-methyl-3-hexene C7H14 98.19 CCC=C(C)CC 14686-14-7 (3E)-3-HEPTEN C7H14 98.19 CCCC=CCC 7385-78-6 3,4-DIMETHYL-1-PENTEN C7H14 98.19 CC(C)C(C)C=C 7385-82-2 (2E)-5-METHYL-2-HEXEN C7H14 98.19 CC(C)CC=CC 3683-22-5 TRANS-4-METHYL-2-HEXEN C7H14 98.19 CCC(C)C=CC 692-24-0 2-METHYL-TRANS-3-HEXEN C7H14 98.19 CCC=CC(C)C 1638-26-2 1,1-DIMETHYLCYCLOPENTAN C7H14 98.19 CC1(C)CCCC1 822-50-4 TRANS-1,2-DIMETHYLCYCLOPENTAN C7H14 98.19 CC1CCCC1C 1192-18-3 CIS-1,2-DIMETHYLCYCLOPENTAN C7H14 98.19 CC1CCCC1C 2532-58-3 CIS-1,3-DIMETHYLCYCLOPENTAN C7H14 98.19 CC1CC(C)CC1 1759-58-6 TRANS-1,3-DIMETHYLCYCLOPENTAN C7H14 98.19 CC1CC(C)CC1 1640-89-7 ETHYLCYCLOPENTAN C7H14 98.19 CCC1CCCC1 108-87-2 METHYLCYCLOHEXAN C7H14 98.19 CC1CCCCC1 291-64-5 CYCLOHEPTAN C7H14 98.19 C1CCCCCC1 359-10-4 1,1-DIFLUOR-2-CHLORETHEN C2HClF2 98.48 ClC=C(F)F 13863-59-7 BROMFLUORID BrF 98.90 FBr 75-44-5 KOHLENSAEUREDICHLORID CCl2O 98.92 ClC(Cl)=O 107-06-2 1,2-DICHLORETHAN C2H4Cl2 98.96 ClCCCl 75-34-3 1,1-DICHLORETHAN C2H4Cl2 98.96 CC(Cl)Cl 753-90-2 2,2,2-trifluoroethylamine C2H4F3N 99.06 NCC(F)(F)F 623-49-4 ethylcyanoformate C4H5NO2 99.09 CCOC(=O)C#N 10004-44-1 3-hydroxy-5-methylisoxazole C4H5NO2 99.09 Oc1cc(C)on1 6154-04-7 2-METHYL-2H-TETRAZOL-5-AMIN C2H5N5 99.09 Nc1nn(C)nn1 1001-55-4 glycolonitrileacetate C4H5NO2 99.09 CC(OCC#N)=O 17647-70-0 4-methylfurazanamine C3H5N3O 99.09 Nc1nonc1C 105-34-0 CYANESSIGSAEUREMETHYLESTER C4H5NO2 99.09 COC(CC#N)=O 52838-39-8 2-amino-5-me-1,3,4-oxadiazole C3H5N3O 99.09 Nc1oc(C)nn1 123-56-8 2,5-PYRROLIDINDION C4H5NO2 99.09 O=C1NC(CC1)=O 5422-44-6 1-METHYL-1H-TETRAZOL-5-AMIN C2H5N5 99.09 Nc1nnnn1C 140-87-4 CYANOESSIGSAEUREHYDRAZID C3H5N3O 99.09 N#CCC(=O)NN 1192-28-5 cyclopentanoneoxime C5H9NO 99.13 ON=C1CCCC1 10021-64-4 2-hydroxy-3-methylbutanenitrile C5H9NO 99.13 CC(C)C(O)C#N 2141-62-0 3-ETHOXYPROPANNITRIL C5H9NO 99.13 CCOCCC#N 15856-96-9 CIS-2-PENTENAMID C5H9NO 99.13 CCC=CC(=O)N 77311-02-5 2,4-dimethyl-2,5-dihydro-1,3-oxazole C5H9NO 99.13 CC1N=C(C)CO1 872-50-4 N-METHYL-2-PYRROLIDON C5H9NO 99.13 CN1CCCC1=O 3760-54-1 1-PYRROLIDINCARBOXALDEHYD C5H9NO 99.13 O=CN1CCCC1 108-27-0 5-methyl-2-pyrrolidinone C5H9NO 99.13 CC1NC(CC1)=O 675-20-7 2-PIPERIDON C5H9NO 99.13 O=C1NCCCC1

Page 18 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 111-36-4 1-ISOCYANATOBUTAN C5H9NO 99.13 CCCCN=C=O 1609-86-5 2-ISOCYANATO-2-METHYLPROPAN C5H9NO 99.13 CC(C)(C)N=C=O 1873-29-6 1-ISOCYANATO-2-METHYLPROPAN C5H9NO 99.13 CC(C)CN=C=O 57-06-7 3-ISOTHIOCYANATO-1-PROPEN C4H5NS 99.16 C=CCN=C=S 764-49-8 3-thiocyanato-propene C4H5NS 99.16 N#CSCC=C 693-95-8 4-METHYLTHIAZOL C4H5NS 99.16 Cc1cscn1 3581-87-1 2-METHYLTHIAZOL C4H5NS 99.16 Cc1sccn1 18328-90-0 N-ETHYL-2-METHYL-2-PROPEN-1-AMIN C6H13N 99.17 CCNCC(C)=C 626-67-5 N-METHYLPIPERIDIN C6H13N 99.17 CN1CCCCC1 7335-06-0 N-ETHYLPYRROLIDIN C6H13N 99.17 CCN1CCCC1 111-49-9 HEXAHYDRO-1H-AZEPIN C6H13N 99.17 N1CCCCCC1 626-58-4 4-METHYLPIPERIDIN C6H13N 99.17 CC1CCNCC1 109-05-7 2-METHYLPIPERIDIN C6H13N 99.17 CC1CCCCN1 1120-85-0 1-butylaziridine C6H13N 99.17 CCCCN1CC1 5666-21-7 N-PROPYL-2-PROPEN-1-AMIN C6H13N 99.17 CCCNCC=C 40571-45-7 1-methyl-cyclopentanamine C6H13N 99.17 NC1(C)CCCC1 108-91-8 CYCLOHEXANAMIN C6H13N 99.17 NC1CCCCC1 116-14-3 TETRAFLUORETHEN C2F4 100.02 FC(F)=C(F)F 75-89-8 2,2,2-TRIFLUORETHANOL C2H3F3O 100.04 OCC(F)(F)F 421-14-7 TRIFLUORMETHOXYMETHAN C2H3F3O 100.04 COC(F)(F)F 7789-21-1 FLUORSCHWEFELSAEURE HFO3S 100.07 FS(O)(=O)=O 108-30-5 DIHYDRO-2,5-FURANDION C4H4O3 100.07 O=C1OC(CC1)=O 17220-38-1 furazandiamine C2H4N4O 100.08 Nc1nonc1N 6939-12-4 3-METHYLSYDNON C3H4N2O2 100.08 CN(=NO1)=CC1=O 461-72-3 hydantoin C3H4N2O2 100.08 O=C1NC(=O)NC1 16419-78-6 2,4-HEXADIINEDINITRIL C6N2 100.08 N#CC#CC#CC#N 105-38-4 PROPANSAEUREETHENYLESTER C5H8O2 100.12 CCC(OC=C)=O 3721-95-7 CYCLOBUTANCARBONSAEURE C5H8O2 100.12 OC(C1CCC1)=O 80-59-1 (2E)-2-METHYL-2-BUTENSAEURE C5H8O2 100.12 CC=C(C)C(O)=O 29555-02-0 2-methylcyclopropanecarboxylicacid C5H8O2 100.12 CC1CC1C(O)=O 626-98-2 2-PENTENSAEURE C5H8O2 100.12 CCC=CC(O)=O 541-47-9 3-METHYL-2-BUTENSAEURE C5H8O2 100.12 CC(C)=CC(O)=O 600-14-6 2,3-PENTANDION C5H8O2 100.12 CCC(=O)C(C)=O 80-62-6 2-METHYL-2-PROPENSAEUREMETHYLESTER C5H8O2 100.12 COC(=O)C(C)=C 140-88-5 2-PROPENSAEUREETHYLESTER C5H8O2 100.12 CCOC(=O)C=C 108-22-5 1-PROPEN-2-OLACETAT C5H8O2 100.12 CC(OC(C)=C)=O 591-80-0 4-PENTENSAEURE C5H8O2 100.12 OC(CCC=C)=O 623-43-8 2-BUTENSAEUREMETHYLESTER C5H8O2 100.12 COC(=O)C=CC 2868-37-3 CYCLOPROPANCARBONSAEUREMETHYLESTER C5H8O2 100.12 COC(C1CC1)=O 13256-13-8 n-nitroso-ethylvinylamine C4H8N2O 100.12 CCN(N=O)C=C 591-87-7 ESSIGSAEUREALLYLESTER C5H8O2 100.12 CC(OCC=C)=O 4587-00-2 1-(2-methyloxiranyl)-ethanone C5H8O2 100.12 CC1(OC1)C(C)=O 3188-00-9 2-methyloxolan-3-one C5H8O2 100.12 CC1OCCC1=O 4549-43-3 n-nitrosomethylallylamine C4H8N2O 100.12 C=CCN(C)N=O 123-54-6 2,4-PENTANDION C5H8O2 100.12 CC(CC(C)=O)=O 7681-84-7 TETRAHYDRO-2-FURANCARBOXYLDEHYD C5H8O2 100.12 O=CC1CCCO1 108-29-2 DIHYDRO-5-METHYL-2(3H)-FURANON C5H8O2 100.12 CC1OC(CC1)=O 111-30-8 GLUTARDIALDEHYD C5H8O2 100.12 O=CCCCC=O 29943-42-8 4-TERTAHYDROPYRANON C5H8O2 100.12 O=C1CCOCC1 930-55-2 n-nitrosopyrrolidine C4H8N2O 100.12 O=NN1CCCC1 542-28-9 TETRAHYDRO-2H-PYRAN-2-ON C5H8O2 100.12 O=C1CCCCO1 557-11-9 allylurea C4H8N2O 100.12 C=CCNC(=O)N 20893-64-5 2(3h)-thiophenone C4H4OS 100.14 O=C1SC=CC1 96-50-4 2-THIAZOLAMIN C3H4N2S 100.14 Nc1sccn1 50406-54-7 5-methyl-1,2,3-thiadiazole C3H4N2S 100.14 Cc1snnc1 4798-45-2 2-METHYL-4-PENTEN-3-OL C6H12O 100.16 CC(C)C(O)C=C 1471-03-0 3-PROPOXY-1-PROPEN C6H12O 100.16 CCCOCC=C 5362-55-0 4-methyl-2-penten-1-ol C6H12O 100.16 OCC=CC(C)C 2088-07-5 2-methyl-1-penten-3-ol C6H12O 100.16 CCC(O)C(C)=C 4798-44-1 1-HEXEN-3-OL C6H12O 100.16 CCCC(O)C=C 3637-61-4 CYCLOPENTANMETHANOL C6H12O 100.16 OCC1CCCC1 1462-03-9 1-METHYLCYCLOPENTANOL C6H12O 100.16 OC1(C)CCCC1

Page 19 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 18729-48-1 3-METHYLCYCLOPENTANOL C6H12O 100.16 OC1CC(C)CC1 25144-05-2 cis-2-methylcyclopentanol C6H12O 100.16 OC1CCCC1C 4798-58-7 2-HEXEN-4-OL C6H12O 100.16 CCC(O)C=CC 108-93-0 CYCLOHEXANOL C6H12O 100.16 OC1CCCCC1 928-95-0 TRANS-HEX-2-ENOL-1 C6H12O 100.16 CCCC=CCO 926-02-3 TERT.-BUTYLVINYLETHER C6H12O 100.16 CC(C)(C)OC=C 10473-13-9 2,3-dimethyl-3-buten-2-ol C6H12O 100.16 OC(C)(C)C(C)=C 1610-29-3 2-METHYL-2-PENTEN-1-OL C6H12O 100.16 CCC=C(C)CO 928-94-9 (z)-hex-2-en-1-ol C6H12O 100.16 CCCC=CCO 63468-05-3 2-methyl-pent-3-en-2-ol C6H12O 100.16 OC(C)(C)C=CC 821-41-0 1-HEXEN-6-OL C6H12O 100.16 OCCCCC=C 1569-59-1 3-methyl-4-penten-2-ol C6H12O 100.16 OC(C)C(C)C=C 123-15-9 2-METHYLPENTANAL C6H12O 100.16 CCCC(C)C=O 544-12-7 3-HEXEN-1-OL C6H12O 100.16 OCCC=CCC 928-96-1 (3Z)-3-HEXEN-1-OL C6H12O 100.16 OCCC=CCC 97-96-1 2-ETHYLBUTANAL C6H12O 100.16 CCC(CC)C=O 928-92-7 (e)-4-hexen-1-ol C6H12O 100.16 OCCCC=CC 1436-34-6 1,2-HEXENOXID C6H12O 100.16 CCCCC1OC1 15877-57-3 3-METHYLPENTANAL C6H12O 100.16 CCC(C)CC=O 626-94-8 5-hexen-2-ol C6H12O 100.16 OC(C)CCC=C 66-25-1 HEXANAL C6H12O 100.16 CCCCCC=O 2004-67-3 4-methyl-pent-4-en-2-ol C6H12O 100.16 OC(C)CC(C)=C 565-69-5 2-METHYL-3-PENTANON C6H12O 100.16 CCC(C(C)C)=O 589-38-8 3-HEXANON C6H12O 100.16 CCCC(CC)=O 108-10-1 4-METHYL-2-PENTANON C6H12O 100.16 CC(C)CC(C)=O 26093-63-0 TETRAHYDRO-3-METHYL-2H-PYRAN C6H12O 100.16 CC1CCCOC1 75-97-8 3,3-DIMETHYL-2-BUTANON C6H12O 100.16 CC(C)(C)C(C)=O 591-78-6 2-HEXANON C6H12O 100.16 CCCCC(C)=O 565-61-7 3-METHYL-2-PENTANON C6H12O 100.16 CCC(C)C(C)=O 592-90-5 OXEPAN C6H12O 100.16 O1CCCCCC1 2144-41-4 2,5-dimethyltetrahydrofuran0 C6H12O 100.16 CC1OC(C)CC1 1003-30-1 2-ETHYLTETRAHYDROFURAN C6H12O 100.16 CCC1CCCO1 2213-43-6 1-aminopiperidine C5H12N2 100.16 NN1CCCCC1 109-01-3 N-METHYLPIPERAZIN C5H12N2 100.16 CN1CCNCC1 109-07-9 2-methylpiperazine C5H12N2 100.16 CC1CNCCN1 111-34-2 1-(ETHENYLOXY)BUTAN C6H12O 100.16 CCCCOC=C 109-53-5 VINYLISOBUTYLETHER C6H12O 100.16 CC(C)COC=C 464-06-2 2,2,3-TRIMETHYLBUTAN C7H16 100.20 CC(C)C(C)(C)C 565-59-3 2,3-DIMETHYLPENTAN C7H16 100.20 CCC(C)C(C)C 562-49-2 3,3-DIMETHYLPENTAN C7H16 100.20 CCC(C)(C)CC 108-08-7 2,4-DIMETHYLPENTAN C7H16 100.20 CC(C)CC(C)C 590-35-2 2,2-DIMETHYLPENTAN C7H16 100.20 CCCC(C)(C)C 617-78-7 3-ETHYLPENTAN C7H16 100.20 CCC(CC)CC 591-76-4 2-METHYLHEXAN C7H16 100.20 CCCCC(C)C 589-34-4 3-METHYLHEXAN C7H16 100.20 CCCC(C)CC 142-82-5 HEPTAN C7H16 100.20 CCCCCCC 754-05-2 ETHENYLTRIMETHYLSILAN C5H12Si 100.23 C[Si](C)(C)C=C 7601-90-3 PERCHLORSAEURE HClO4 100.46 OCl(=O)(=O)=O 25497-29-4 CHLORDIFLUORETHAN C2H3ClF2 100.50 ClCC(F)F 75-68-3 1-CHLOR-1,1-DIFLUORETHAN C2H3ClF2 100.50 FC(F)(C)Cl 41851-50-7 5-chloro-1,3-cyclopentadiene C5H5Cl 100.55 ClC1C=CC=C1 4109-96-0 DICHLORSILAN H2Cl2Si 101.01 Cl[SiH2]Cl 3232-84-6 urazole C2H3N3O2 101.06 O=c1[nH]c(=O)[nH][nH]1 57-71-6 2,3-butanedionemonooxime C4H7NO2 101.10 ON=C(C)C(C)=O 625-77-4 N-ACETYLACETAMID C4H7NO2 101.10 CC(=O)NC(C)=O 2517-04-6 2-azetidinecarboxylicacid C4H7NO2 101.10 OC(C1CCN1)=O 22059-21-8 1-aminocyclopropanecarboxylicacid C4H7NO2 101.10 NC1(CC1)C(O)=O 591-86-6 2-ethylidenehydrazinecarboxamide C3H7N3O 101.11 CC=NNC(=O)N 56-03-1 biguanide C2H7N5 101.11 N=C(N)NC(=N)N 61296-28-4 cyanothiourea C2H3N3S 101.13 N#CNC(N)=S 4005-51-0 aminothiadiazole C2H3N3S 101.13 Nc1scnn1 623-40-5 2-PENTANONOXIM C5H11NO 101.15 CCC(CC)=NO

Page 20 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 626-90-4 3-methyl-butyraldehydeoxime C5H11NO 101.15 CC(C)CC=NO 2425-74-3 TERT.-BUTYLFORMAMID C5H11NO 101.15 CC(C)(C)NC=O 626-97-1 VALERIANSAEUREAMID C5H11NO 101.15 CCCCC(=O)N 754-10-9 2,2-DIMETHYLPROPIONSAEUREAMID C5H11NO 101.15 CC(C)(C)C(=O)N 109-02-4 4-METHYLMORPHOLIN C5H11NO 101.15 CN1CCOCC1 541-46-8 3-METHYLBUTANAMID C5H11NO 101.15 CC(C)CC(=O)N 617-84-5 N,N-DIETHYLFORMAMID C5H11NO 101.15 CCN(CC)C=O 758-96-3 N,N-DIMETHYLPROPANAMID C5H11NO 101.15 CCC(=O)N(C)C 4795-29-3 TETRAHYDRO-2-FURANMETHANAMIN C5H11NO 101.15 NCC1CCCO1 2295-35-4 2-azacyclopentanthione C4H7NS 101.17 S=C1NCCC1 2346-00-1 4,5-dihydro-2-methylthiazole C4H7NS 101.17 CC1=NCCS1 628-30-8 propylisothiocyanate C4H7NS 101.17 CCCN=C=S 2253-73-8 2-isothiocyanatopropane C4H7NS 101.17 CC(C)N=C=S 7239-24-9 N,N-DIMETHYLISOBUTYLAMIN C6H15N 101.19 CN(C)CC(C)C 927-62-8 N,N-DIMETHYL-1-BUTANAMIN C6H15N 101.19 CCCCN(C)C 21968-17-2 N-(1-METHYLETHYL)-1-PROPANAMIN C6H15N 101.19 CCCNC(C)C 142-84-7 N-PROPYL-1-PROPANAMIN C6H15N 101.19 CCCNCCC 13360-63-9 N-ETHYL-1-BUTANAMIN C6H15N 101.19 CCNCCCC 3850-30-4 3,3-DIMETHYL-2-BUTANAMIN C6H15N 101.19 NC(C)C(C)(C)C 108-18-9 N-(1-METHYLETHYL)-2-PROPANAMIN C6H15N 101.19 CC(C)NC(C)C 617-79-8 2-ETHYLBUTYLAMIN C6H15N 101.19 NCC(CC)CC 111-26-2 1-HEXANAMIN C6H15N 101.19 NCCCCCC 5344-20-7 4-METHYL-1-PENTANAMIN C6H15N 101.19 NCCCC(C)C 121-44-8 N,N-DIETHYLETHANAMIN C6H15N 101.19 CCN(CC)CC 4426-47-5 DIHYDROXY-N-BUTYLBORAN C4H11BO2 101.94 CCCCB(O)O 359-35-3 1,1,2,2-TETRAFLUORETHAN C2H2F4 102.03 FC(F)C(F)F 811-97-2 1,1,1,2-TETRAFLUORETHAN C2H2F4 102.03 FCC(F)(F)F 2699-79-8 SULFURYLDIFLUORID F2O2S 102.06 FS(F)(=O)=O 108-24-7 ESSIGSAEUREANHYDRID C4H6O3 102.09 CC(OC(C)=O)=O 600-18-0 2-oxobutanoicacid C4H6O3 102.09 CCC(=O)C(O)=O 600-22-6 BRENZTRAUBENSAEUREMETHYLESTER C4H6O3 102.09 COC(=O)C(C)=O 1804-15-5 propanal,2-(hydroxyimino)-,oxime C3H6N2O2 102.09 ON=CC(C)=NO 108-32-7 1,2-PROPYLENCARBONAT C4H6O3 102.09 CC1OC(OC1)=O 541-50-4 BUTANOICACID,3-OXO- C4H6O3 102.09 OC(CC(C)=O)=O 591-07-1 N-(AMINOCARBONYL)ACETAMID C3H6N2O2 102.09 CC(=O)NC(=O)N 68-41-7 d-4-amino-3-isoxazolidinone C3H6N2O2 102.09 NC1CONC1=O 108-13-4 PROPANDIAMID C3H6N2O2 102.09 O=C(CC(=O)N)N 141-83-3 (aminoiminomethyl)-urea C2H6N4O 102.10 O=C(N)NC(=N)N 4743-40-2 PHOSPHACYCLOHEXAN C5H11P 102.12 C1CCPCC1 536-74-3 ETHINYLBENZOL C8H6 102.13 C#Cc1ccccc1 75-98-9 2,2-DIMETHYLPROPANSAEURE C5H10O2 102.13 CC(C)(C)C(O)=O 116-53-0 2-METHYLBUTANSAEURE C5H10O2 102.13 CCC(C)C(O)=O 503-74-2 3-METHYLBUTANSAEURE C5H10O2 102.13 CC(C)CC(O)=O 109-52-4 PENTANSAEURE C5H10O2 102.13 CCCCC(O)=O 592-84-7 AMEISENSAEUREBUTYLESTER C5H10O2 102.13 CCCCOC=O 762-75-4 AMEISENSAEURE-1,1-DIMETHYLETHYLESTER C5H10O2 102.13 CC(C)(C)OC=O 542-55-2 AMEISENSAEURE-2-METHYLPROPYLESTER C5H10O2 102.13 CC(C)COC=O 589-40-2 AMEISENSAEURE-SEC.-BUTYLESTER C5H10O2 102.13 CCC(C)OC=O 547-63-7 ISOBUTTERSAEUREMETHYLESTER C5H10O2 102.13 COC(C(C)C)=O 623-42-7 BUTANSAEUREMETHYLESTER C5H10O2 102.13 CCCC(OC)=O 105-37-3 PROPANSAEUREETHYLESTER C5H10O2 102.13 CCOC(CC)=O 2568-96-9 2-ETHYL-1,3-DIOXOLAN C5H10O2 102.13 CCC1OCCO1 109-60-4 ESSIGSAEUREPROPYLESTER C5H10O2 102.13 CCCOC(C)=O 6044-68-4 3,3-dimethoxy-1-propene C5H10O2 102.13 COC(OC)C=C 108-21-4 ESSIGSAEURE-1-METHYLETHYLESTER C5H10O2 102.13 CC(C)OC(C)=O 3390-12-3 2,4-DIMETHYL-1,3-DIOXOLAN C5H10O2 102.13 CC1OC(C)CO1 99506-67-9 3-hydroxy-2-methylbutanal C5H10O2 102.13 OC(C)C(C)C=O 597-31-9 HYDROXYPIVALINALDEHYD C5H10O2 102.13 OCC(C)(C)C=O 111-45-5 2-allyloxyethanol C5H10O2 102.13 OCCOCC=C 2916-31-6 2,2-DIMETHYL-1,3-DIOXOLAN C5H10O2 102.13 CC1(C)OCCO1 4016-11-9 (ETHOXYMETHYL)OXIRAN C5H10O2 102.13 CCOCC1OC1 3142-66-3 3-hydroxypentan-2-one C5H10O2 102.13 CCC(O)C(C)=O

Page 21 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 97-99-4 TETRAHYDRO-2-FURANMETHANOL C5H10O2 102.13 OCC1CCCO1 1120-97-4 4-METHYL-1,3-DIOXAN C5H10O2 102.13 CC1CCOCO1 115-22-0 3-OXY-3-METHYL-2-BUTANON C5H10O2 102.13 OC(C)(C)C(C)=O 3393-64-4 4-HYDROXY-3-METHYL-2-BUTANON C5H10O2 102.13 OCC(C)C(C)=O 4161-60-8 4-HYDROXY-2-PENTANON C5H10O2 102.13 OC(C)CC(C)=O 1071-73-4 5-HYDROXY-2-PENTANON C5H10O2 102.13 OCCCC(C)=O 16326-97-9 cis-1,3-cyclopentanediol C5H10O2 102.13 OC1CC(O)CC1 924-46-9 n-nitrosomethylpropylamine C4H10N2O 102.14 CCCN(C)N=O 55-18-5 DIETHYLNITROSAMIN C4H10N2O 102.14 CCN(CC)N=O 4319-49-7 4-morpholinamine C4H10N2O 102.14 NN1CCOCC1 632-14-4 TRIMETHYLHARNSTOFF C4H10N2O 102.14 CNC(=O)N(C)C 3619-17-8 i-butryicacidhydrazide C4H10N2O 102.14 CC(C)C(=O)NN 3538-65-6 butryicacidhydrazide C4H10N2O 102.14 CCCC(=O)NN 927-67-3 propylthiourea C4H10N2O 102.14 CCCNC(=O)N 691-60-1 (1-METHYLETHYL)HARNSTOFF C4H10N2O 102.14 CC(C)NC(=O)N 372-46-3 FLUORCYCLOHEXAN C6H11F 102.15 FC1CCCCC1 39700-44-2 g-thiobutyrolactone C4H6OS 102.16 S=C1CCCO1 1003-04-9 DIHYDRO-3(2H)-THIOPHENON C4H6OS 102.16 O=C1CSCC1 1115-15-7 1,1'-sulfinylbisethene C4H6OS 102.16 C=CS(=O)C=C 1779-81-3 4,5-dihydro-2-thiazolamine C3H6N2S 102.16 N=C1NCCS1 96-45-7 2-IMIDAZOLIDINTHION C3H6N2S 102.16 S=C1NCCN1 108-11-2 4-METHYL-2-PENTANOL C6H14O 102.18 OC(C)CC(C)C 77-74-7 3-METHYL-3-PENTANOL C6H14O 102.18 CCC(O)(C)CC 626-89-1 4-METHYL-1-PENTANOL C6H14O 102.18 OCCCC(C)C 565-60-6 3-METHYL-2-PENTANOL C6H14O 102.18 CCC(C)C(O)C 624-95-3 3,3-DIMETHYL-1-BUTANOL C6H14O 102.18 OCCC(C)(C)C 62016-48-2 2-METHYLBUTYLMETHYLETHER C6H14O 102.18 COCC(C)CC 594-60-5 2,3-DIMETHYL-2-BUTANOL C6H14O 102.18 CC(C)C(O)(C)C 2679-87-0 ETHYL-SEK.-BUTYLETHER C6H14O 102.18 CCOC(C)CC 589-35-5 3-METHYL-1-PENTANOL C6H14O 102.18 OCCC(C)CC 565-67-3 2-METHYL-3-PENTANOL C6H14O 102.18 CCC(O)C(C)C 626-93-7 2-HEXANOL C6H14O 102.18 CCCCC(O)C 464-07-3 3,3-DIMETHYL-2-BUTANOL C6H14O 102.18 OC(C)C(C)(C)C 623-37-0 3-HEXANOL C6H14O 102.18 CCCC(O)CC 111-27-3 1-HEXANOL C6H14O 102.18 OCCCCCC 51-80-0 n,n,n',n'-tetramethylmethylenediamine C5H14N2 102.18 CN(C)CN(C)C 97-95-0 2-ETHYL-1-BUTANOL C6H14O 102.18 OCC(CC)CC 19550-30-2 2,3-DIMETHYL-1-BUTANOL C6H14O 102.18 OCC(C)C(C)C 1185-33-7 2,2-DIMETHYL-1-BUTANOL C6H14O 102.18 OCC(C)(C)CC 627-02-1 1-ETHOXY-2-METHYLPROPAN C6H14O 102.18 CCOCC(C)C 111-43-3 DIPROPYLETHER C6H14O 102.18 CCCOCCC 628-81-9 1-ETHOXYBUTAN C6H14O 102.18 CCOCCCC 626-91-5 1-METHOXY-3-METHYLBUTAN C6H14O 102.18 COCCC(C)C 628-80-8 1-METHOXYPENTAN C6H14O 102.18 COCCCCC 994-05-8 (1,1-DIMETHYLPROPYL)-METHYLETHER C6H14O 102.18 COC(C)(C)CC 105-30-6 2-METHYL-1-PENTANOL C6H14O 102.18 CCCC(C)CO 637-92-3 2-ETHOXY-2-METHYLPROPAN C6H14O 102.18 CCOC(C)(C)C 108-20-3 DIISOPROPYLETHER C6H14O 102.18 CC(C)OC(C)C 627-08-7 1-(1-METHYLETHOXY)PROPAN C6H14O 102.18 CCCOC(C)C 142-25-6 n,n,n'-trimethylethanediamine C5H14N2 102.18 CNCCN(C)C 109-55-7 3-DIMETHYLAMINOPROPYLAMIN C5H14N2 102.18 NCCCN(C)C 462-94-2 1,5-PENTANDIAMIN C5H14N2 102.18 NCCCCCN 5287-45-6 3-methylbut-2-ene-1-thiol C5H10S 102.20 SCC=C(C)C 1795-09-1 2-METHYLTHIACYCLOPENTAN C5H10S 102.20 CC1SCCC1 4740-00-5 3-METHYLTETRAHYDROTHIOPHEN C5H10S 102.20 CC1CSCC1 1613-51-0 THIACYCLOHEXAN C5H10S 102.20 C1CCSCC1 1679-07-8 CYCLOPENTANTHIOL C5H10S 102.20 SC1CCCC1 18143-31-2 DIMETHYLPROPYLSILAN C5H14Si 102.25 CCC[SiH](C)C 7616-94-6 PERCHLORYLFLUORID((CLO3)F) ClFO3 102.45 FCl(=O)(=O)=O 50689-17-3 3-chlorofuran C4H3ClO 102.52 Clc1cocc1 1111-97-3 3-chloro-3-methyl-1-butyne C5H7Cl 102.56 CC(C)(Cl)C#C 75-43-4 DICHLORFLUORMETHAN CHCl2F 102.92 FC(Cl)Cl

Page 22 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 10545-99-0 SCHWEFELCHLORID(SCL2) Cl2S 102.97 ClSCl 684-93-5 n-nitroso-n-methylurea C2H5N3O2 103.08 CN(N=O)C(=O)N 2491-15-8 n-formylglycine C3H5NO3 103.08 OC(=O)CNC=O 515-96-8 oxamichydrazide C2H5N3O2 103.08 NNC(=O)C(=O)N 108-19-0 IMIDODIKOHLENSAEUREDIAMID C2H5N3O2 103.08 O=C(N)NC(=O)N 997-76-2 ETHENTRICARBONITRIL C5HN3 103.08 N#CC=C(C#N)C#N 625-74-1 2-METHYL-1-NITROPROPAN C4H9NO2 103.12 CC(C)CN(=O)=O 594-70-7 2-METHYL-2-NITROPROPAN C4H9NO2 103.12 CC(C)(C)N(=O)=O 600-24-8 2-NITROBUTAN C4H9NO2 103.12 CCC(C)N(=O)=O 627-05-4 1-NITROBUTAN C4H9NO2 103.12 CCCCN(=O)=O 100-47-0 BENZONITRIL C7H5N 103.12 N#Cc1ccccc1 6135-31-5 N-ETHYL-METHYLCARBAMAT C4H9NO2 103.12 CCNC(OC)=O 1746-77-6 isopropylcarbamate C4H9NO2 103.12 CC(C)OC(=O)N 627-12-3 CARBAMIDSAEUREPROPYLESTER C4H9NO2 103.12 CCCOC(=O)N 105-40-8 N-METHYLCARBAMINSAEUREETHYLESTER C4H9NO2 103.12 CCOC(=O)NC 1118-68-9 glycine,n,n-dimethyl C4H9NO2 103.12 CN(C)CC(O)=O 459-73-4 amino-aceticacidethylester C4H9NO2 103.12 CCOC(CN)=O 22718-51-0 4,4-dimethylsemicarbazide C3H9N3O 103.12 CN(C)C(=O)NN 13050-41-4 4-ethylsemicarbazide C3H9N3O 103.12 CCNC(=O)NN 142-26-7 N-(2-HYDROXYETHYL)ACETAMID C4H9NO2 103.12 OCCNC(C)=O 2679-14-3 n-methyl-,beta,-alanine C4H9NO2 103.12 C[NH2+]CCC([O-])=O 540-80-7 TERT-BUTYLNITRIT C4H9NO2 103.12 CC(C)(C)ON=O 924-43-6 SEC-BUTYLNITRIT C4H9NO2 103.12 CCC(C)ON=O 544-16-1 BUTYLNITRIT C4H9NO2 103.12 CCCCON=O 542-56-3 SALPETRIGESAEURE2-METHYLPROPYLESTER C4H9NO2 103.12 CC(C)CON=O 541-48-0 3-aminobutanoicacid C4H9NO2 103.12 CC([NH3+])CC([O-])=O 56-12-2 4-AMINOBUTANSAEURE C4H9NO2 103.12 [NH3+]CCCC([O-])=O 62-57-7 2-AMINO-2-METHYLPROPIONSAEURE C4H9NO2 103.12 CC(C)([NH3+])C([O-])=O 80-60-4 alpha-aminobutyricacid C4H9NO2 103.12 CCC([NH3+])C([O-])=O 16369-21-4 2-(PROPYLAMINO)ETHANOL C5H13NO 103.16 OCCNCCC 109-56-8 2-(ISOPROPYLAMINO)-ETHANOL C5H13NO 103.16 OCCNC(C)C 2508-29-4 5-AMINOPENTANOL C5H13NO 103.16 OCCCCCN 108-16-7 1-DIMETHYLAMINO-2-PROPANOL C5H13NO 103.16 OC(C)CN(C)C 15521-18-3 2-(DIMETHYLAMINO)-1-PROPANOL C5H13NO 103.16 OCC(C)N(C)C 3179-63-3 3-DIMETHYLAMINO-1-PROPANOL C5H13NO 103.16 OCCCN(C)C 111-40-0 BIS-(2-AMINOETHYL)-AMIN C4H13N3 103.17 NCCNCCN 123-90-0 thiomorpholine C4H9NS 103.19 N1CCSCC1 18166-02-4 methanamine,1-(trimethylsilyl)- C4H13NSi 103.24 NC[Si](C)(C)C 628-20-6 4-CHLORBUTANNITRIL C4H6ClN 103.55 ClCCCC#N 121-43-7 BORSAEURE(H3BO3)TRIMETHYLESTER C3H9BO3 103.91 COB(OC)OC 10036-47-2 STICKSTOFFFLUORID(N2F4) F4N2 104.01 FN(F)N(F)F 1113-60-6 3-hydroxy-2-oxopropanoic acid C3H4O4 104.06 OCC(=O)C(O)=O 141-82-2 PROPANDISAEURE C3H4O4 104.06 OC(CC(O)=O)=O 556-88-7 NITROGUANIDIN CH4N4O2 104.07 O=N(=O)N=C(N)N 7783-61-1 SILICIUMTETRAFLUORID F4Si 104.08 F[Si](F)(F)F 594-61-6 2-HYDROXYISOBUTTERSAEURE C4H8O3 104.10 OC(C)(C)C(O)=O 627-03-2 2-ETHOXYESSIGSAEURE C4H8O3 104.10 CCOCC(O)=O 547-64-8 2-HYDROXYPROPANSAEUREMETHYLESTER C4H8O3 104.10 COC(C(O)C)=O 623-50-7 HYDROXYESSIGSAEUREETHYLESTER C4H8O3 104.10 CCOC(CO)=O 6149-41-3 3-HYDROXYPROPIONSAEUREMETHYLESTER C4H8O3 104.10 OCCC(OC)=O 6290-49-9 METHYLMETHOXYACETAT C4H8O3 104.10 COCC(OC)=O 542-59-6 ETHYLENGLYKOLMONOACETAT C4H8O3 104.10 OCCOC(C)=O 5464-28-8 4-HYDROXYMETHYL-1,3-OXOLAN C4H8O3 104.10 OCC1COCO1 600-15-7 2-hydroxy-butyricacid C4H8O3 104.10 CCC(O)C(O)=O 300-85-6 BETA-HYDROXYBUTYRICACID C4H8O3 104.10 OC(C)CC(O)=O 4114-31-2 HYDRAZINECARBOXYLICACIDETHYLESTER C3H8N2O2 104.11 CCOC(=O)NN 100-70-9 2-PYRIDINCARBONITRIL C6H4N2 104.11 N#Cc1ccccn1 100-48-1 4-CYANPYRIDIN C6H4N2 104.11 N#Cc1ccncc1 100-54-9 3-CYANPYRIDIN C6H4N2 104.11 N#Cc1cccnc1 7433-42-3 1-ethylhydroxyurea C3H8N2O2 104.11 CCN(O)C(=O)N 5710-11-2 3-ethylhydroxyurea C3H8N2O2 104.11 CCNC(=O)NO 7285-32-7 THIETESULFON C3H4O2S 104.13 O=S1(=O)C=CC1

Page 23 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 52125-53-8 1,2-propanediolmonoethylether C5H12O2 104.15 CCOC(O)CC 50468-22-9 3-METHYL-1,2-BUTANDIOL C5H12O2 104.15 OCC(O)C(C)C 42027-23-6 2,3-PENTANDIOL C5H12O2 104.15 CCC(O)C(O)C 126-30-7 NEOPENTYLGLYKOL C5H12O2 104.15 OCC(C)(C)CO 5396-58-7 2-METHYL-2,3-BUTANDIOL C5H12O2 104.15 OC(C)C(O)(C)C 626-95-9 1,4-PENTANDIOL C5H12O2 104.15 OCCCC(O)C 684-84-4 2-METHYL-1,3-BUTANDIOL C5H12O2 104.15 OCC(C)C(O)C 625-69-4 2,4-PENTANDIOL C5H12O2 104.15 OC(C)CC(O)C 111-32-0 1,3-butyleneglycolmethylether C5H12O2 104.15 COCCCCO 2568-33-4 3-METHYL-1,3-BUTANDIOL C5H12O2 104.15 OCCC(O)(C)C 462-95-3 3,5-DIOXAHEPTAN C5H12O2 104.15 CCOCOCC 2807-30-9 2-PROPOXYETHANOL C5H12O2 104.15 OCCOCCC 77-76-9 2,2-DIMETHOXYPROPAN C5H12O2 104.15 COC(C)(C)OC 1569-02-4 1-ETHOXY-2-PROPANOL C5H12O2 104.15 CCOCC(O)C 111-29-5 1,5-PENTANDIOL C5H12O2 104.15 OCCCCCO 19089-47-5 2-ethoxy-1-propanol C5H12O2 104.15 CCOC(C)CO 111-35-3 3-ETHOXY-1-PROPANOL C5H12O2 104.15 CCOCCCO 109-59-1 2-(1-METHYLETHOXY)ETHANOL C5H12O2 104.15 OCCOC(C)C 2517-43-3 3-METHOXY-1-BUTANOL C5H12O2 104.15 OCCC(C)OC 7778-85-0 PROPENGLYKOLDIMETHYLETHER C5H12O2 104.15 COCC(C)OC 2752-17-2 ETHANAMINE,2,2-OXYBIS- C4H12N2O 104.15 NCCOCCN 111-41-1 2-AMINO-2`-HYDROXYDIETHYLAMIN C4H12N2O 104.15 OCCNCCN 629-20-9 1,3,5,7-CYCLOOCTATETRAEN C8H8 104.15 c1ccccccc1 100-42-5 ETHENYLBENZOL C8H8 104.15 C=Cc1ccccc1 277-10-1 PENTACYCLO-(4.2.02,5.03,8.04,7)-OCTAN C8H8 104.15 C1(C3C2C54)C2C4C1C53 625-60-5 ETHYLTHIOLACETAT C4H8OS 104.17 CCSC(C)=O 3268-49-3 PROPANAL,3-(METHYLTHIO)- C4H8OS 104.17 CSCCC=O 40789-98-8 3-sulfanylbutan-2-one C4H8OS 104.17 CC(S)C(C)=O 34619-12-0 4-sulfanylbutan-2-one C4H8OS 104.17 SCCC(C)=O 14109-72-9 1-methylsulfanylpropan-2-one C4H8OS 104.17 CSCC(C)=O 15980-15-1 1,4-OXATHIAN C4H8OS 104.17 O1CCSCC1 534-13-4 N,N`-DIMETHYLTHIOHARNSTOFF C3H8N2S 104.17 CNC(=S)NC 6972-05-0 n,n-dimethyl-thiourea C3H8N2S 104.17 CN(C)C(N)=S 625-53-6 ETHYLTHIOHARNSTOFF C3H8N2S 104.17 CCNC(N)=S 373-14-8 1-FLUORHEXAN C6H13F 104.17 FCCCCCC 6163-64-0 2-METHYL-2-(METHYLTHIO)PROPAN C5H12S 104.21 CSC(C)(C)C 5145-99-3 2-METHYL-3-THIAPENTAN C5H12S 104.21 CCSC(C)C 4110-50-3 3-THIAHEXAN C5H12S 104.21 CCCSCC 628-29-5 1-(METHYLTHIO)BUTAN C5H12S 104.21 CCCCSC 541-31-1 3-METHYL-1-BUTANTHIOL C5H12S 104.21 SCCC(C)C 1679-09-0 1,1-DIMETHYLPROPYLMERCAPTAN C5H12S 104.21 CCC(C)(C)S 110-66-7 1-PENTANTHIOL C5H12S 104.21 CCCCCS 1878-18-8 2-METHYL-1-BUTANTHIOL C5H12S 104.21 CCC(C)CS 2084-18-6 3-METHYL-2-BUTANTHIOL C5H12S 104.21 CC(C)C(C)S 5008-69-5 2-METHYL-1-(METHYLTHIO)PROPAN C5H12S 104.21 CSCC(C)C 2084-19-7 2-PENTANTHIOL C5H12S 104.21 CCCC(C)S 616-31-9 3-PENTANTHIOL C5H12S 104.21 CCC(S)CC 5314-83-0 diethylchloroborane C4H10BCl 104.39 CCB(Cl)CC 75-72-9 CHLORTRIFLUORMETHAN CClF3 104.46 FC(F)(F)Cl 10487-71-5 CROTONYLCHLORID C4H5ClO 104.54 CC=CC(Cl)=O 53175-28-3 2-chloro-2-butenal C4H5ClO 104.54 CC=C(Cl)C=O 920-46-7 2-METHYL-2-PROPENOYLCHLORID C4H5ClO 104.54 CC(=C)C(Cl)=O 503-60-6 1-CHLOR-3-METHYL-2-BUTEN C5H9Cl 104.58 ClCC=C(C)C 928-50-7 5-CHLOR-1-PENTEN C5H9Cl 104.58 ClCCCC=C 5166-35-8 3-CHLOR-2-METHYL-1-BUTEN C5H9Cl 104.58 CC(Cl)C(C)=C 13417-43-1 1-chloro-2-methyl-2-butene C5H9Cl 104.58 ClCC(C)=CC 930-28-9 CHLORCYCLOPENTAN C5H9Cl 104.58 ClC1CCCC1 17773-65-8 2-CHLOR-3-METHYL-2-BUTEN C5H9Cl 104.58 CC(C)=C(C)Cl 21450-13-5 1-chloro-1-pentene C5H9Cl 104.58 CCCC=CCl 23010-00-6 1-chloro-3-methyl-1-butene C5H9Cl 104.58 CC(C)C=CCl 23378-11-2 1-chloro-2-methyl-1-butene C5H9Cl 104.58 CCC(C)=CCl 556-89-8 NITROHARNSTOFF CH3N3O3 105.05 O=N(=O)NC(=O)N

Page 24 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 1712-64-7 SALPETERSAEURE-1-METHYLETHYLESTER C3H7NO3 105.09 CC(C)ON(=O)=O 627-13-4 SALPETERSAEUREPROPYLESTER C3H7NO3 105.09 CCCON(=O)=O 632-12-2 isoserine C3H7NO3 105.09 NCC(O)C(O)=O 56-45-1 3-HYDROXY-L-ALANIN C3H7NO3 105.09 OCC([NH3+])C([O-])=O 14080-23-0 2-pyrimidinecarbonitrile C5H3N3 105.10 N#Cc1ncccn1 19847-12-2 PYRAZINE-2-CARBONITRILE C5H3N3 105.10 N#Cc1cnccn1 42839-04-3 4-pyrimidinecarbonitrile C5H3N3 105.10 N#Cc1ccncn1 40805-79-6 5-pyrimidinecarbonitrile C5H3N3 105.10 N#Cc1cncnc1 10359-20-3 1,1,1-ETHANTRICARBONITRIL C5H3N3 105.10 CC(C#N)(C#N)C#N 68776-62-5 4-pyridazinecarbonitrile C5H3N3 105.10 N#Cc1ccnnc1 100-69-6 2-ETHENYLPYRIDIN C7H7N 105.14 C=Cc1ccccn1 1337-81-1 m-vinylpyridine C7H7N 105.14 C=Cc1cccnc1 100-43-6 4-ETHENYLPYRIDIN C7H7N 105.14 C=Cc1ccncc1 115-69-5 2-AMINO-2-METHYL-1,3-PROPANDIOL C4H11NO2 105.14 OCC(N)(C)CO 111-42-2 DIETHANOLAMIN C4H11NO2 105.14 OCCNCCO 929-06-6 2-(2-AMINOETHOXY)-ETHANOL C4H11NO2 105.14 OCCOCCN 13749-94-5 1-(mes)-acetaldehydeoxime C3H7NOS 105.16 CSC(C)=NO 637-98-9 thiocarbamicacids-ethylester C3H7NOS 105.16 CCSC(=O)N 625-57-0 o-ethylthiocarbamate C3H7NOS 105.16 CCOC(N)=S 16490-68-9 2-chloro-2-propenamide C3H4ClNO 105.52 ClC(=C)C(=O)N 506-68-3 CYANOGENBROMID((CN)BR) CBrN 105.92 BrC#N 593-57-7 DIMETHYLARSEN C2H7As 106.00 C[AsH]C 593-59-9 ethylarsine C2H7As 106.00 CC[AsH2] 473-81-4 glycericacid C3H6O4 106.08 OCC(O)C(O)=O 459-72-3 ETHYLFLUORACETAT C4H7FO2 106.10 CCOC(CF)=O 100-52-7 BENZALDEHYD C7H6O 106.12 O=Cc1ccccc1 623-39-2 3-METHOXY-1,2-PROPANDIOL C4H10O3 106.12 COCC(O)CO 149-73-5 ORTHOAMEISENSAEURETRIMETHYLESTER C4H10O3 106.12 COC(OC)OC 539-80-0 2,4,6-CYCLOHEPTATRIEN-1-ON C7H6O 106.12 O=C1C=CC=CC=C1 111-46-6 DIETHYLENGLYKOL C4H10O3 106.12 OCCOCCO 4435-50-1 1,2,3-BUTANTRIOL C4H10O3 106.12 OCC(O)C(O)C 3068-00-6 1,2,4-BUTANTRIOL C4H10O3 106.12 OCCC(O)CO 2141-58-4 2-HEXENEDINITRILE-(Z) C6H6N2 106.13 N#CCCC=CC#N 2141-59-5 2-HEXENEDINITRILE-(E) C6H6N2 106.13 N#CCCC=CC#N 1119-85-3 DICYAN-2-BUTEN C6H6N2 106.13 N#CCC=CCC#N 79-42-5 2-MERCAPTOPROPANSAEURE C3H6O2S 106.14 CC(S)C(O)=O 107-96-0 3-MERCAPTOPROPANSAEURE C3H6O2S 106.14 SCCC(O)=O 2231-57-4 carbonothioicdihydrazide CH6N4S 106.15 NNC(=S)NN 871-84-1 1,7-OCTADIIN C8H10 106.17 C#CCCCCC#C 1871-52-9 1,3,5-cyclooctatriene C8H10 106.17 C1C=CC=CC=CC1 95-47-6 1,2-DIMETHYLBENZOL C8H10 106.17 Cc1ccccc1C 100-41-4 ETHYLBENZOL C8H10 106.17 CCc1ccccc1 108-38-3 1,3-DIMETHYLBENZOL C8H10 106.17 Cc1cc(C)ccc1 106-42-3 1,4-DIMETHYLBENZOL C8H10 106.17 Cc1ccc(C)cc1 54812-86-1 3-sulfanylbutan-2-ol C4H10OS 106.19 OC(C)C(C)S 505-10-2 3-methylsulfanylpropan-1-ol C4H10OS 106.19 OCCCSC 110-77-0 2-(ETHYLMERCAPTO)-ETHANOL C4H10OS 106.19 OCCSCC 70-29-1 DIETHYLSULFOXID C4H10OS 106.19 CCS(CC)=O 4829-04-3 1,3-DITHIOLAN C3H6S2 106.21 C1SCSC1 110-75-8 (2-CHLOR-)ETHYLVINYLETHER C4H7ClO 106.55 ClCCOC=C 917-93-1 2-chloro-2-methylpropanal C4H7ClO 106.55 CC(C)(Cl)C=O 598-09-4 2-(chloromethyl)-2-methyloxirane C4H7ClO 106.55 ClCC1(C)OC1 4091-39-8 3-CHLOR-2-BUTANON C4H7ClO 106.55 CC(Cl)C(C)=O 75455-41-3 4-hydroxy-3-chloro-1-butene C4H7ClO 106.55 OCC(Cl)C=C 671-56-7 3-hydroxy-4-chloro-1-butene C4H7ClO 106.55 ClCC(O)C=C 616-27-3 1-CHLOR-2-BUTANON C4H7ClO 106.55 CCC(CCl)=O 6322-49-2 4-CHLOR-2-BUTANON C4H7ClO 106.55 ClCCC(C)=O 141-75-3 BUTANOYLCHLORID C4H7ClO 106.55 CCCC(Cl)=O 79-30-1 2-METHYLPROPANOYLCHLORID C4H7ClO 106.55 CC(C)C(Cl)=O 594-36-5 2-CHLOR-2-METHYLBUTAN C5H11Cl 106.59 CCC(C)(C)Cl 625-29-6 2-CHLORPENTAN C5H11Cl 106.59 CCCC(C)Cl 107-84-6 1-CHLOR-3-METHYLBUTAN C5H11Cl 106.59 ClCCC(C)C

Page 25 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 543-59-9 1-PENTYLCHLORID C5H11Cl 106.59 CCCCCCl 616-20-6 3-CHLORPENTAN C5H11Cl 106.59 CCC(Cl)CC 753-89-9 NEOPENTYLCHLORID C5H11Cl 106.59 ClCC(C)(C)C 593-60-2 BROMETHEN C2H3Br 106.95 BrC=C 16051-48-2 1,2-ETHANDIOLMONONITRAT C2H5NO4 107.07 OCCON(=O)=O 586-96-9 NITROSOBENZOL C6H5NO 107.11 O=Nc1ccccc1 2745-25-7 2-cyanomethylfuran C6H5NO 107.11 N#CCc1occc1 872-85-5 4-PYRIDINCARBOXALDEHYD C6H5NO 107.11 O=Cc1ccncc1 500-22-1 3-PYRIDINCARBOXALDEHYD C6H5NO 107.11 O=Cc1cccnc1 1121-60-4 2-PYRIDINCARBOXALDEHYD C6H5NO 107.11 O=Cc1ccccn1 100-61-8 N-METHYLBENZOLAMIN C7H9N 107.15 CNc1ccccc1 95-53-4 2-METHYLANILIN C7H9N 107.15 Nc1ccccc1C 108-44-1 3-METHYLANILIN C7H9N 107.15 Nc1cc(C)ccc1 106-49-0 4-METHYLBENZOLAMIN C7H9N 107.15 Nc1ccc(C)cc1 100-71-0 2-ETHYLPYRIDIN C7H9N 107.15 CCc1ccccn1 583-61-9 2,3-DIMETHYLPYRIDIN C7H9N 107.15 Cc1ncccc1C 108-48-5 2,6-DIMETHYLPYRIDIN C7H9N 107.15 Cc1nc(C)ccc1 536-78-7 3-ETHYLPYRIDIN C7H9N 107.15 CCc1cccnc1 589-93-5 2,5-DIMETHYLPYRIDIN C7H9N 107.15 Cc1ccc(C)cn1 536-75-4 4-ETHYLPYRIDIN C7H9N 107.15 CCc1ccncc1 591-22-0 3,5-DIMETHYLPYRIDIN C7H9N 107.15 Cc1cc(C)cnc1 108-47-4 2,4-DIMETHYLPYRIDIN C7H9N 107.15 Cc1cc(C)ccn1 583-58-4 3,4-DIMETHYLPYRIDIN C7H9N 107.15 Cc1cnccc1C 100-46-9 BENZOLMETHANAMIN C7H9N 107.15 NCc1ccccc1 79-44-7 DIMETHYLCARBAMIDSAEURECHLORID C3H6ClNO 107.54 CN(C)C(Cl)=O 3268-79-9 chloromethylthiocyanate C2H2ClNS 107.56 ClCSC#N 10102-03-1 STICKSTOFFOXID(N2O5) N2O5 108.01 O=N(ON(=O)=O)=O 16391-07-4 methylphosphinicacidethylester C3H9O2P 108.08 CCO[PH](C)=O 106-51-4 1,4-BENZOCHINON C6H4O2 108.10 O=C1C=CC(=O)C=C1 3741-38-6 ETHYLENGLYKOLSULFIT C2H4O3S 108.12 O=S1OCCO1 100-66-3 METHOXYBENZOL C7H8O 108.14 COc1ccccc1 100-51-6 BENZOLMETHANOL C7H8O 108.14 OCc1ccccc1 695-05-6 3-nortricyclenone C7H8O 108.14 O=C2C3C1CC2CC31 106-44-5 4-METHYLPHENOL C7H8O 108.14 Oc1ccc(C)cc1 108-39-4 3-METHYLPHENOL C7H8O 108.14 Oc1cc(C)ccc1 95-48-7 2-METHYLPHENOL C7H8O 108.14 Oc1ccccc1C 4597-87-9 N-METHYL-2-PYRIDINAMIN C6H8N2 108.14 CNc1ccccn1 1824-81-3 6-methyl-2-pyridinamine C6H8N2 108.14 Nc1nc(C)ccc1 1603-41-4 6-amino-3-picoline C6H8N2 108.14 Nc1ccc(C)cn1 1603-40-3 3-METHYL-2-PYRIDINAMIN C6H8N2 108.14 Nc1ncccc1C 695-34-1 4-METHYL-2-PYRIDINAMIN C6H8N2 108.14 Nc1cc(C)ccn1 100-63-0 PHENYLHYDRAZIN C6H8N2 108.14 NNc1ccccc1 13925-00-3 2-ethylpyrazine C6H8N2 108.14 CCc1cnccn1 95-54-5 1,2-DIAMINOBENZOL C6H8N2 108.14 Nc1ccccc1N 5910-89-4 2,3-DIMETHYLPYRAZIN C6H8N2 108.14 Cc1nccnc1C 14331-54-5 2,4-DIMETHYLPYRIMIDIN C6H8N2 108.14 Cc1nc(C)ccn1 108-50-9 2,6-dimethylpyrazine C6H8N2 108.14 Cc1nc(C)cnc1 123-32-0 2,5-DIMETHYLPYRAZIN C6H8N2 108.14 Cc1ncc(C)nc1 1558-17-4 4,6-dimethylpyrimidine C6H8N2 108.14 Cc1cc(C)ncn1 4553-62-2 PENTANEDINITRILE,2-METHYL- C6H8N2 108.14 CC(CCC#N)C#N 3731-53-1 4-(AMINOMETHYL)-PYRIDIN C6H8N2 108.14 NCc1ccncc1 3731-51-9 2-(AMINOMETHYL)-PYRIDIN C6H8N2 108.14 NCc1ccccn1 3731-52-0 3-(AMINOMETHYL)-PYRIDIN C6H8N2 108.14 NCc1cccnc1 108-45-2 1,3-DIAMINOBENZOL C6H8N2 108.14 Nc1cc(N)ccc1 106-50-3 1,4-BENZOLDIAMIN C6H8N2 108.14 Nc1ccc(N)cc1 111-69-3 ADIPINSAEUREDINITRIL C6H8N2 108.14 N#CCCCCC#N 96-27-5 3-MERCAPTO-1,2-PROPANDIOL C3H8O2S 108.16 OCC(O)CS 594-43-4 ETHYLMETHYLSULFON C3H8O2S 108.16 CCS(C)(=O)=O 111-78-4 1,5-CYCLOOCTADIEN C8H12 108.18 C1C=CCCC=CC1 4916-63-6 2,5-dimethyl-1,3,5-hexatriene C8H12 108.18 CC(=C)C=CC(C)=C 2422-85-7 1,2-DIETHENYLCYCLOBUTAN C8H12 108.18 C=CC1CCC1C=C 100-40-3 4-ETHENYLCYCLOHEXEN C8H12 108.18 C=CC1CC=CCC1

Page 26 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 2622-21-1 1-vinylcyclohexene C8H12 108.18 C=CC1=CCCCC1 1073-07-0 1,4-CYCLOOCTADIEN C8H12 108.18 C1CC=CCC=CC1 31463-35-1 7-METHYLENBICYCLO(2.2.1)HEPTAN C8H12 108.18 C=C1C2CCC1CC2 694-92-8 2-METHYLBICYCLO(2.2.1)HEPT-2-EN C8H12 108.18 CC2=CC1CC2CC1 931-64-6 BICYCLO[2.2.2]OCT-2-EN C8H12 108.18 C(C1)C2CCC1C=C2 694-53-1 PHENYLSILAN C6H8Si 108.21 [SiH3]c1ccccc1 1618-26-4 BIS(METHYLTHIO)METHAN C3H8S2 108.23 CSCSC 814-67-5 1,2-PROPANDITHIOL C3H8S2 108.23 SCC(C)S 109-80-8 1,3-PROPANDITHIOL C3H8S2 108.23 SCCCS 20333-39-5 DISULFIDE,ETHYLMETHYL C3H8S2 108.23 CCSSC 38870-89-2 methoxyacetylchloride C3H5ClO2 108.52 COCC(Cl)=O 625-56-9 chloromethacetate C3H5ClO2 108.52 ClCOC(C)=O 96-34-4 CHLORESSIGSAEUREMETHYLESTER C3H5ClO2 108.52 COC(CCl)=O 541-41-3 CHLORKOHLENSAEUREETHYLESTER C3H5ClO2 108.52 CCOC(Cl)=O 107-94-8 3-CHLORPROPANSAEURE C3H5ClO2 108.52 ClCCC(O)=O 598-78-7 2-CHLORPROPANSAEURE C3H5ClO2 108.52 CC(Cl)C(O)=O 5390-71-6 2-chloro-1-methoxypropane C4H9ClO 108.57 COCC(C)Cl 36215-07-3 1-CHLOR-3-METHOXYPROPAN C4H9ClO 108.57 COCCCCl 1873-25-2 1-CHLOR-2-BUTANOL C4H9ClO 108.57 CCC(O)CCl 7081-78-9 1-CHLOR-1-ETHOXYETHAN C4H9ClO 108.57 CCOC(C)Cl 558-42-9 1-CHLOR-2-METHYL-2-PROPANOL C4H9ClO 108.57 ClCC(O)(C)C 928-51-8 4-chloro-1-butanol C4H9ClO 108.57 OCCCCCl 563-84-8 3-CHLOR-2-BUTANOL C4H9ClO 108.57 OC(C)C(C)Cl 628-34-2 1-CHLOR-2-ETHOXYETHAN C4H9ClO 108.57 CCOCCCl 1320-66-7 butylenechlorhydrin C4H9ClO 108.57 CCCC(O)Cl 75-77-4 CHLORTRIMETHYLSILAN C3H9ClSi 108.64 C[Si](C)(C)Cl 83682-32-0 1,3-dichloroallene C3H2Cl2 108.95 ClC=C=CCl 25523-14-2 3,3-dichloropropyne C3H2Cl2 108.95 ClC(Cl)C#C 74-96-4 BROMETHAN C2H5Br 108.97 CCBr 593-79-3 DIMETHYLSELEN C2H6Se 109.03 C[Se]C 1116-01-4 TRICYANOPHOSPHIN C3N3P 109.03 N#CP(C#N)C#N 18615-86-6 2-METHYL-4-PYRIDINOL C6H7NO 109.13 Cc1cc(O)ccn1 1121-25-1 2-METHYL-3-PYRIDINOL C6H7NO 109.13 Cc1ncccc1O 1121-78-4 6-METHYL-3-PYRIDINOL C6H7NO 109.13 Oc1ccc(C)nc1 1628-89-3 2-METHOXYPYRIDIN C6H7NO 109.13 COc1ccccn1 586-95-8 4-PYRIDINMETHANOL C6H7NO 109.13 OCc1ccncc1 586-98-1 2-PYRIDINMETHANOL C6H7NO 109.13 OCc1ccccn1 1072-83-9 1-(1h-pyrrol-2-yl)-ethanone C6H7NO 109.13 CC(=O)c1[nH]ccc1 100-65-2 N-HYDROXYBENZOLAMIN C6H7NO 109.13 ONc1ccccc1 100-55-0 3-PYRIDINMETHANOL C6H7NO 109.13 OCc1cccnc1 1192-58-1 1-methylpyrrole-2-carbaldehyde C6H7NO 109.13 Cn1cccc1C=O 2941-29-9 2-CYANOCYCLOPENTANON C6H7NO 109.13 N#CC1CCCC1=O 95-55-6 2-AMINOPHENOL C6H7NO 109.13 Oc1ccccc1N 108-52-1 4-METHYL-2-PYRIMIDINAMIN C5H7N3 109.13 Nc1nc(C)ccn1 5521-56-2 6-methylpyrazinamine C5H7N3 109.13 Nc1nc(C)cnc1 32111-28-7 2-methylaminopyrazine C5H7N3 109.13 CNc1cnccn1 4930-98-7 2(1h)-pyridinonehydrazone C5H7N3 109.13 NNc1ccccn1 7295-76-3 3-METHOXYPYRIDIN C6H7NO 109.13 COc1cccnc1 3435-28-7 6-methyl-4-pyrimidinamine C5H7N3 109.13 Nc1cc(C)ncn1 620-08-6 4-METHOXYPYRIDIN C6H7NO 109.13 COc1ccncc1 931-19-1 2-PICOLIN-N-OXID C6H7NO 109.13 Cc1ccccn1=O 6714-29-0 2,3-dihydro-1h-imidazo(1,2-b)pyrazole C5H7N3 109.13 C(Nc1c2)Cn1nc2 591-27-5 3-AMINOPHENOL C6H7NO 109.13 Oc1cc(N)ccc1 123-30-8 4-AMINOPHENOL C6H7NO 109.13 Oc1ccc(N)cc1 1003-73-2 3-METHYLPYRIDIN-1-OXID C6H7NO 109.13 Cc1cn(ccc1)=O 694-85-9 1-METHYL-2(1H)-PYRIDINON C6H7NO 109.13 CN1C=CC=CC1=O 1003-67-4 4-methylpyridine-1-oxide C6H7NO 109.13 Cc1ccn(cc1)=O 141-86-6 2,6-DIAMINOPYRIDIN C5H7N3 109.13 Nc1nc(N)ccc1 3279-76-3 6-METHYL-2(1H)-PYRIDINON C6H7NO 109.13 CC1=CC=CC(=O)N1 1003-56-1 3-methyl-2(1h)-pyridinone C6H7NO 109.13 CC1=CC=CNC1=O 695-19-2 1-methyl-4(1h)-pyridinone C6H7NO 109.13 CN1C=CC(=O)C=C1 13466-41-6 4-methyl-2(1h)-pyridinone C6H7NO 109.13 CC1=CC(=O)NC=C1

Page 27 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 4318-76-7 2,5-diaminopyridine C5H7N3 109.13 Nc1ccc(N)cn1 54-96-6 3,4-pyridinediamine C5H7N3 109.13 Nc1cnccc1N 1003-31-2 2-THIOPHENCARBONITRIL C5H3NS 109.15 N#Cc1sccc1 930-87-0 1,2,5-trimethylpyrrole C7H11N 109.17 Cc1ccc(C)n1C 598-92-5 1-chloro-1-nitroethane C2H4ClNO2 109.51 CC(Cl)N(=O)=O 625-47-8 1-chloro-2-nitroethane C2H4ClNO2 109.51 ClCCN(=O)=O 3018-12-0 DICHLORACETONITRIL C2HCl2N 109.94 ClC(Cl)C#N 868-85-9 PHOSPHORIGSAEUREDIMETHYLESTER C2H7O3P 110.05 CO[PH](OC)=O 15845-66-6 fosetyl C2H7O3P 110.05 CCP(O)(O)=O 638-21-1 phenylphosphine C6H7P 110.09 Pc1ccccc1 1192-62-7 1-(2-FURANYL)ETHANON C6H6O2 110.11 CC(=O)c1occc1 620-02-0 5-METHYLFURFUROL C6H6O2 110.11 Cc1oc(C=O)cc1 3149-28-8 METHOXYPYRAZIN C5H6N2O 110.11 COc1cnccn1 6104-41-2 4-methoxypyrimidine C5H6N2O 110.11 COc1ccncn1 123-31-9 1,4-BENZOLDIOL C6H6O2 110.11 Oc1ccc(O)cc1 931-63-5 2-methoxypyrimidine C5H6N2O 110.11 COc1ncccn1 108-46-3 1,3-BENZOLDIOL C6H6O2 110.11 Oc1cc(O)ccc1 120-80-9 1,2-BENZOLDIOL C6H6O2 110.11 Oc1ccccc1O 31458-33-0 5-methoxypyrimidine C5H6N2O 110.11 COc1cncnc1 19064-65-4 3-methoxypyridazine C5H6N2O 110.11 COc1cccnn1 18409-46-6 e,e-2,4-hexadienedial C6H6O2 110.11 O=CC=CC=CC=O 20733-11-3 4-methoxypyridazine C5H6N2O 110.11 COc1ccnnc1 2466-76-4 imidazole,1-acetyl C5H6N2O 110.11 CC(=O)n1ccnc1 14150-95-9 2-pyridinamine,1-oxide C5H6N2O 110.11 Nc1ccccn1=O 4551-72-8 1h-pyrrole-2-carboxamide C5H6N2O 110.11 O=C(c1[nH]ccc1)N 15231-48-8 2pyrimidone4methyl C5H6N2O 110.11 CC1=NC(=O)NC=C1 41536-80-5 2,6-pyrazinediamine C4H6N4 110.12 Nc1nc(N)cnc1 616-42-2 DIMETHYLSULFIT C2H6O3S 110.13 COS(OC)=O 66-27-3 METHANSULFONSAEUREMETHYLESTER C2H6O3S 110.13 COS(C)(=O)=O 350-50-5 (FLUORMETHYL)BENZOL C7H7F 110.13 FCc1ccccc1 594-45-6 ETHANSULFONSAEURE C2H6O3S 110.13 CCS(O)(=O)=O 352-32-9 1-FLUOR-4-METHYLBENZOL C7H7F 110.13 Fc1ccc(C)cc1 352-70-5 1-FLUOR-3-METHYLBENZOL C7H7F 110.13 Fc1cc(C)ccc1 95-52-3 1-FLUOR-2-METHYLBENZOL C7H7F 110.13 Fc1ccccc1C 1452-15-9 4-THIAZOLCARBONITRIL C4H2N2S 110.14 N#Cc1cscn1 13080-90-5 5-norbornen-2-ol C7H10O 110.15 OC2CC1C=CC2C1 278-74-0 3-oxatricyclo[3.2.1.0(2,4)-]octane C7H10O 110.15 C2CC3C1OC1C2C3 17356-19-3 1-ETHINYLCYCLOPENTANOL C7H10O 110.15 OC1(CCCC1)C#C 100-50-5 1,2,3,6-TETRAHYDROBENZALDEHYD C7H10O 110.15 O=CC1CC=CCC1 10218-02-7 BICYCLO[2.2.1]HEPTAN-7-ON C7H10O 110.15 O=C1C2CCC1CC2 1121-37-5 DICYCLOPROPYLMETHANON C7H10O 110.15 O=C(C2CC2)C1CC1 31883-98-4 3-methyl-cyclohex-3-enone C7H10O 110.15 CC(CC1=O)=CCC1 497-38-1 BICYCLO[2.2.1]HEPTAN-2-ON C7H10O 110.15 O=C2CC1CC2CC1 4313-03-5 trans,trans-2,4-heptadienal C7H10O 110.15 CCC=CC=CC=O 1193-18-6 3-METHYL-2-CYCLOHEXEN-1-ON C7H10O 110.15 CC1=CC(CCC1)=O 4229-91-8 2-PROPYLFURAN C7H10O 110.15 CCCc1occc1 1703-52-2 1-ethyl-5-methylfuran C7H10O 110.15 CCc(cc1)oc1C 1072-91-9 1,3,5-TRIMETHYL-1H-PYRAZOL C6H10N2 110.16 Cc(cc1C)nn1C 108-98-5 BENZOLTHIOL C6H6S 110.18 Sc1ccccc1 629-05-0 1-OCTIN C8H14 110.20 CCCCCCC#C 2809-67-8 2-OCTIN C8H14 110.20 CCCCCC#CC 15232-76-5 3-OCTIN C8H14 110.20 CCCCC#CCC 1942-45-6 4-OCTIN C8H14 110.20 CCCC#CCCC 627-58-7 2,5-DIMETHYL-1,5-HEXADIEN C8H14 110.20 CC(CCC(C)=C)=C 3710-30-3 1,7-OCTADIEN C8H14 110.20 C=CCCCCC=C 764-13-6 2,5-DIMETHYL-2,4-HEXADIEN C8H14 110.20 CC(CC=C(C)C)=C 4974-27-0 2,6-OCTADIEN C8H14 110.20 CC=CCCC=CC 2808-80-2 1-METHYL-4-METHYLENCYCLOHEXAN C8H14 110.20 CC1CCC(CC1)=C 2808-71-1 3-ETHYLCYCLOHEXEN C8H14 110.20 CCC1C=CCCC1 695-12-5 ETHENYLCYCLOHEXAN C8H14 110.20 C=CC1CCCCC1 3524-75-2 2-PROPENYLCYCLOPENTAN C8H14 110.20 C=CCC1CCCC1 14072-86-7 4,4-DIMETHYL-1-CYCLOHEXEN C8H14 110.20 CC1(C)CC=CCC1

Page 28 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 931-88-4 CYCLOOCTEN C8H14 110.20 C1CCC=CCCC1 1003-64-1 ETHYLIDENCYCLOHEXAN C8H14 110.20 CC=C1CCCCC1 1453-25-4 1-METHYLCYCLOHEPTEN C8H14 110.20 CC1=CCCCCC1 1453-24-3 1-ETHYLCYCLOHEXEN C8H14 110.20 CCC1=CCCCC1 1674-10-8 1,2-DIMETHYLCYCLOHEXEN C8H14 110.20 CC1=C(C)CCCC1 694-72-4 bicyclo(3,3,0)octane C8H14 110.20 C(CC1C2)CC1CC2 280-33-1 BICYCLO(2.2.2)OCTAN C8H14 110.20 C(C1)C2CCC1CC2 594-08-1 TRITHIOKOHLENSAEURE CH2S3 110.22 SC(S)=S 96-24-2 1-CHLOR-2,3-PROPANDIOL C3H7ClO2 110.54 OCC(O)CCl 497-04-1 2-CHLOR-1,3-PROPANDIOL C3H7ClO2 110.54 OCC(Cl)CO 462-73-7 1-chloro-4-fluorobutane C4H8ClF 110.56 FCCCCCl 7446-08-4 SELENOXID(SEO2) O2Se 110.96 O=[Se]=O 542-75-6 1,3-DICHLORPROPYLEN(ISOMERENGEMISCH) C3H4Cl2 110.97 ClCC=CCl 10061-02-6 (1E)-1,3-DICHLOR-1-PROPEN C3H4Cl2 110.97 ClCC=CCl 78-88-6 2,3-DICHLOR-1-PROPEN C3H4Cl2 110.97 ClCC(Cl)=C 10061-01-5 (1Z)-1,3-DICHLOR-1-PROPEN C3H4Cl2 110.97 ClCC=CCl 563-57-5 3,3-DICHLOR-1-PROPEN C3H4Cl2 110.97 ClC(Cl)C=C 563-54-2 1,2-DICHLOR-1-PROPEN C3H4Cl2 110.97 ClC=C(C)Cl 563-58-6 1,1-DICHLOR-1-PROPEN C3H4Cl2 110.97 CC=C(Cl)Cl 137-05-3 2-CYANO-2-PROPENSAEUREMETHYLESTER C5H5NO2 111.10 COC(=O)C(=C)C#N 930-88-1 n-methylmaleimide C5H5NO2 111.10 CN1C(=O)C=CC1=O 634-97-9 PYRROL-2-CARBONSAEURE C5H5NO2 111.10 OC(=O)c1[nH]ccc1 626-03-9 4-hydroxy-2(1h)-pyridone C5H5NO2 111.10 Oc1cc(O)ccn1 609-38-1 furan-2-carboxamide C5H5NO2 111.10 O=C(c1occc1)N 609-35-8 furan-3-carboxamide C5H5NO2 111.10 O=C(c1cocc1)N 6602-28-4 3-pyridinol-1-oxide C5H5NO2 111.10 Oc1cn(ccc1)=O 108-53-2 2-AMINO-4(1H)-PYRIMIDINON C4H5N3O 111.10 O=C1NC(N)=NC=C1 71-30-7 4-AMINO-2(1H)-PYRIMIDINON C4H5N3O 111.10 O=C1N=C(N)C=CN1 348-54-9 2-FLUORBENZOLAMIN C6H6FN 111.12 Fc1ccccc1N 371-40-4 4-FLUORBENZOLAMIN C6H6FN 111.12 Fc1ccc(N)cc1 372-19-0 3-FLUORANILIN C6H6FN 111.12 Fc1cc(N)ccc1 2229-00-7 2-cyclohexen-1-one-oxime C6H9NO 111.14 ON=C1C=CCCC1 88-12-0 1-ETHENYL-2-PYRROLIDINON C6H9NO 111.14 C=CN1CCCC1=O 20662-84-4 2,4,5-trimethyl-1,3-oxazole C6H9NO 111.14 Cc(nc1C)oc1C 4753-75-7 n-methyl-2-furanmethanamine C6H9NO 111.14 CNCc1occc1 105-20-4 betazole C5H9N3 111.15 NCCc1n[nH]cc1 51-45-6 histamine C5H9N3 111.15 NCCc1[nH]cnc1 2637-34-5 2(1h)-pyridinethione C5H5NS 111.17 S=C1NC=CC=C1 19829-29-9 4(1h)-pyridinethione C5H5NS 111.17 S=C1C=CNC=C1 629-08-3 HEPTANSAEURENITRIL C7H13N 111.19 CCCCCCC#N 100-76-5 1-AZABICYCLO(2.2.2)OCTAN C7H13N 111.19 C(C2)N1CCC2CC1 421-50-1 1,1,1-TRIFLUORACETON C3H3F3O 112.05 FC(F)(F)C(C)=O 616-02-4 3-METHYL-2,5-FURANDION C5H4O3 112.08 CC1=CC(OC1=O)=O 488-93-7 3-FURANCARBONSAEURE C5H4O3 112.08 OC(=O)c1cocc1 496-64-0 3-hydroxy-2h-pyran-2-one C5H4O3 112.08 OC1=CC=COC1=O 88-14-2 2-FURANCARBONSAEURE C5H4O3 112.08 OC(=O)c1occc1 496-63-9 3-hydroxy-4h-pyran-4-one C5H4O3 112.08 OC1=COC=CC1=O 2170-03-8 METHYLENBERNSTEINSAEUREANHYDRID C5H4O3 112.08 O=C(OC1=O)CC1=C 1193-24-4 4,6-PYRIMIDINDIOL C4H4N2O2 112.09 Oc1cc(O)ncn1 123-33-1 maleichydrazideacid C4H4N2O2 112.09 Oc1ccc(O)nn1 129016-38-2 6-hydroxy-3(2h)-pyridazinone C4H4N2O2 112.09 OC1=NNC(=O)C=C1 2423-84-9 pyrazine-1,4-dioxide C4H4N2O2 112.09 O=n1ccn(=O)cc1 66-22-8 2,4(1H,3H)-PYRIMIDINDION C4H4N2O2 112.09 O=c1[nH]c([nH]cc1)=O 543-21-5 2-BUTYNEDIAMID C4H4N2O2 112.09 O=C(N)C#CC(=O)N 25286-58-2 4,6(1h,5h)-pyrimidinedione C4H4N2O2 112.09 O=C1N=CNC(C1)=O 367-12-4 2-FLUORPHENOL C6H5FO 112.10 Fc1ccccc1O 371-41-5 4-FLUORPHENOL C6H5FO 112.10 Fc1ccc(O)cc1 372-20-3 3-FLUORPHENOL C6H5FO 112.10 Fc1cc(O)ccc1 75-93-4 methylsulfate CH4O4S 112.11 COS(O)(=O)=O 999-55-3 allylacrylate C6H8O2 112.13 C=CCOC(=O)C=C 110-44-1 SORBINSAEURE C6H8O2 112.13 CC=CC=CC(O)=O 4341-76-8 but-2-ynoicacidethylester C6H8O2 112.13 CCOC(=O)C#CC

Page 29 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 4208-64-4 a-methyl-2-furanmethanol C6H8O2 112.13 OC(C)c1occc1 3857-25-8 (5-methylfuran-2-yl)methanol C6H8O2 112.13 OCc(cc1)oc1C 10316-66-2 2-hydroxycyclohex-2-en-1-one C6H8O2 112.13 OC1=CCCCC1=O 764-33-0 hex-2-ynoicacid C6H8O2 112.13 CCCC#CC(O)=O 13679-46-4 2-(methoxymethyl)-furan C6H8O2 112.13 COCc1occc1 17647-69-7 ethylmethylfurazan C5H8N2O 112.13 CCc1nonc1C 765-70-8 3-methylcyclopentane-1,2-dione C6H8O2 112.13 CC1CCC(=O)C1=O 765-87-7 1,2-cyclohexanedione C6H8O2 112.13 O=C1CCCCC1=O 820-69-9 trans-3-hexene-2,5-dione C6H8O2 112.13 CC(=O)C=CC(C)=O 81437-10-7 4-ethoxypyrazole C5H8N2O 112.13 CCOc1c[nH]nc1 55556-92-8 1,2,3,6-tetrahydro-1-nitrosopyridine C5H8N2O 112.13 O=NN1CC=CCC1 19947-75-2 3,4-DIMETHYL-5-ISOXAZOLAMIN C5H8N2O 112.13 Cc1noc(N)c1C 10048-32-5 parasorbicacid C6H8O2 112.13 CC1OC(=O)C=CC1 14400-67-0 2,5-dimethylfuran-3-one C6H8O2 112.13 CC1OC(C)=CC1=O 504-02-9 1,3-CYCLOHEXANDION C6H8O2 112.13 O=C1CC(CCC1)=O 637-88-7 1,4-CYCLOHEXANDION C6H8O2 112.13 O=C1CCC(CC1)=O 10412-93-8 cyano-aceticacidbenzylamide C5H8N2O 112.13 CCNC(CC#N)=O 31857-31-5 1,3-dimethyl-2-cyanoguanidine C4H8N4 112.13 CNC(NC)=NC#N 1615-14-1 1-(2-hydroxyethyl)imidazole C5H8N2O 112.13 OCCn1ccnc1 498-62-4 THIOPHEN-3-ALDEHYD C5H4OS 112.15 O=Cc1cscc1 98-03-3 2-THIOPHENCARBOXALDEHYD C5H4OS 112.15 O=Cc1sccc1 1679-51-2 1,2,3,6-tetrahydrobenzyl-alcohol C7H12O 112.17 OCC1CC=CCC1 497-36-9 endo-norborneol C7H12O 112.17 OC2CC1CC2CC1 6285-06-9 3-ETHYL-1-PENTIN-3-OL C7H12O 112.17 CCC(O)(CC)C#C 1482-15-1 3,4-dimethyl-1-pentyn-3-ol C7H12O 112.17 CC(C)C(O)(C)C#C 286-16-8 2-oxabicyclo[4.1.0]heptane C7H12O 112.17 C2CCC1OC1CC2 14300-33-5 dicyclopropylcarbinol C7H12O 112.17 OC(C2CC2)C1CC1 2043-61-0 CYCLOHEXANCARBOXALDEHYD C7H12O 112.17 O=CC1CCCCC1 4041-09-2 2,5-dimethylcyclopentanone C7H12O 112.17 CC1CCC(C)C1=O 2883-45-6 1,6-HEPTADIEN-4-OL C7H12O 112.17 OC(CC=C)CC=C 6004-60-0 1-cyclopentylethanone C7H12O 112.17 CC(C1CCCC1)=O 3240-09-3 5-methyl-5-hexen-2-one C7H12O 112.17 CC(CCC(C)=C)=O 2046-23-3 4-cyclopropyl2-butanone C7H12O 112.17 CC(CCC1CC1)=O 583-60-8 2-METHYLCYCLOHEXANON C7H12O 112.17 CC1CCCCC1=O 2463-63-0 2-heptenal C7H12O 112.17 CCCCC=CC=O 589-92-4 4-METHYLCYCLOHEXANON C7H12O 112.17 CC1CCC(CC1)=O 591-24-2 3-METHYLCYCLOHEXANON C7H12O 112.17 CC1CC(CCC1)=O 502-42-1 CYCLOHEPTANON C7H12O 112.17 O=C1CCCCCC1 3010-02-4 (DIETHYLAMINO)ACETONITRIL C6H12N2 112.17 CCN(CC)CC#N 627-70-3 2-PROPANON-(1-METHYLETHYLIDEN)HYDRAZON C6H12N2 112.17 CC(C)=NN=C(C)C 54166-22-2 3,4-DIHYDRO-3,3,4,4-TETRAMETHYL-1,2-DIAZET C6H12N2 112.17 CC1(C)N=NC1(C)C 2432-74-8 HEXANENITRILE,6-AMINO- C6H12N2 112.17 NCCCCCC#N 280-57-9 1,4-DIAZABICYCLO(2.2.2)OCTAN C6H12N2 112.17 C(C1)N2CCN1CC2 632-15-5 3,4-DIMETHYLTHIOPHEN C6H8S 112.19 Cc1cscc1C 1795-01-3 3-ETHYLTHIOPHEN C6H8S 112.19 CCc1cscc1 872-55-9 2-ETHYLTHIOPHEN C6H8S 112.19 CCc1sccc1 632-16-6 2,3-DIMETHYLTHIOPHEN C6H8S 112.19 Cc1ccsc1C 638-00-6 2,4-DIMETHYLTHIOPHEN C6H8S 112.19 Cc1cc(C)sc1 638-02-8 2,5-DIMETHYLTHIOPHEN C6H8S 112.19 Cc1sc(C)cc1 6975-92-4 2,5-DIMETHYL-1-HEXENE C8H16 112.21 CC(C)CCC(C)=C 15870-10-7 2-METHYL-1-HEPTEN C8H16 112.21 CCCCCC(C)=C 13151-04-7 5-METHYL-1-HEPTEN C8H16 112.21 CCC(C)CCC=C 5026-76-6 6-METHYL-1-HEPTEN C8H16 112.21 CC(C)CCCC=C 560-23-6 2,3,3-TRIMETHYL-1-PENTEN C8H16 112.21 CCC(C)(C)C(C)=C 7642-15-1 (4Z)-4-OCTEN C8H16 112.21 CCCC=CCCC 1632-16-2 3-METHYLENHEPTAN C8H16 112.21 CCCCC(CC)=C 16746-86-4 2,3-DIMETHYL-1-HEXEN C8H16 112.21 CCCC(C)C(C)=C 111-66-0 1-OCTEN C8H16 112.21 CCCCCCC=C 7642-04-8 (2Z)-2-OCTEN C8H16 112.21 CCCCCC=CC 7116-86-1 5,5-DIMETHYL-1-HEXEN C8H16 112.21 CCCC(CCC)=C 3404-77-1 3,3-DIMETHYL-1-HEXEN C8H16 112.21 CCCC(C)(C)C=C 19780-66-6 3-ETHYL-2-METHYL-1-PENTEN C8H16 112.21 CCC(CC)C(C)=C

Page 30 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 592-98-3 3-octene-isomer-cis C8H16 112.21 CCCCC=CCC 16106-59-5 4,5-DIMETHYL-1-HEXEN C8H16 112.21 CC(C)C(C)CC=C 3404-58-8 3-ETHYL-1-HEXEN C8H16 112.21 CCCC(CC)C=C 107-39-1 2,4,4-TRIMETHYL-1-PENTEN C8H16 112.21 CC(C)(C)CC(C)=C 3404-67-9 2-ETHYL-3-METHYL-1-PENTEN C8H16 112.21 CCC(C)C(CC)=C 4810-09-7 3-METHYL-1-HEPTEN C8H16 112.21 CCCCC(C)C=C 3404-78-2 2,5-DIMETHYL-2-HEXEN C8H16 112.21 CC(C)CC=C(C)C 107-40-4 2,4,4-TRIMETHYL-2-PENTEN C8H16 112.21 CC(C)(C)C=C(C)C 7145-20-2 2,3-DIMETHYL-2-HEXEN C8H16 112.21 CCCC(C)=C(C)C 13151-05-8 4-METHYL-1-HEPTEN C8H16 112.21 CCCC(C)CC=C 13389-42-9 (2E)-2-OCTEN C8H16 112.21 CCCCCC=CC 598-96-9 3,4,4-TRIMETHYL-2-PENTEN C8H16 112.21 CC(C)(C)C(C)=CC 627-97-4 2-METHYL-2-HEPTEN C8H16 112.21 CCCCC=C(C)C 565-77-5 2,3,4-TRIMETHYL-2-PENTEN C8H16 112.21 CC(C)C(C)=C(C)C 39761-61-0 (Z)-5,5-DIMETHYL-2-HEXEN C8H16 112.21 CC(C)(C)CC=CC 14919-01-8 (3E)-3-OCTEN C8H16 112.21 CCCCC=CCC 4485-16-9 4-methyl-3-heptene C8H16 112.21 CCCC(C)=CCC 14850-23-8 (4E)-4-OCTEN C8H16 112.21 CCCC=CCCC 16745-94-1 3,4-DIMETHYL-1-HEXEN C8H16 112.21 CCC(C)C(C)C=C 690-93-7 (3E)-2,2-DIMETHYL-3-HEXEN C8H16 112.21 CCC=CC(C)(C)C 17618-76-7 2-methyl-3-heptene C8H16 112.21 CCCC=CC(C)C 15910-22-2 2,5-dimethyl-3-hexene C8H16 112.21 CC(C)C=CC(C)C 4259-00-1 1,1,2-TRIMETHYLCYCLOPENTAN C8H16 112.21 CC1CCCC1(C)C 590-66-9 1,1-DIMETHYLCYCLOHEXAN C8H16 112.21 CC1(C)CCCCC1 16747-50-5 1-ETHYL-1-METHYLCYCLOPENTAN C8H16 112.21 CCC1(C)CCCC1 2207-03-6 TRANS-1,3-DIMETHYLCYCLOHEXAN C8H16 112.21 CC1CC(C)CCC1 4516-69-2 1,1,3-TRIMETHYLCYCLOPENTAN C8H16 112.21 CC(CC1)CC1(C)C 2613-69-6 CIS-1,2,3-TRIMETHYLCYCLOPENTAN C8H16 112.21 CC1CCC(C)C1C 4850-28-6 1.ALPHA,2.ALPHA,4.BETA-1,2,4-TRIMETHYLCYCLOPENTAN C8H16 112.21 CC(CC1C)CC1C 2613-72-1 CIS-1,2,4-TRIMETHYLCYCLOPENTAN C8H16 112.21 CC(CC1C)CC1C 583-57-3 1,2-DIMETHYLCYCLOHEXAN(ISOMERENGEMISCH) C8H16 112.21 CC1CCCCC1C 930-89-2 CIS-1-ETHYL-2-METHYLCYCLOPENTAN C8H16 112.21 CCC1CCCC1C 3875-51-2 (1-METHYLETHYL)CYCLOPENTAN C8H16 112.21 CC(C)C1CCCC1 589-90-2 1,4-DIMETHYLCYCLOHEXAN(ISOMERENGEMISCH) C8H16 112.21 CC1CCC(C)CC1 2040-96-2 PROPYLCYCLOPENTAN C8H16 112.21 CCCC1CCCC1 2207-04-7 TRANS-1,4-DIMETHYLCYCLOHEXAN C8H16 112.21 CC1CCC(C)CC1 15890-40-1 TRANS,CIS-1,2,3-TRIMETHYLCYCLOPENTAN C8H16 112.21 CC1CCC(C)C1C 591-21-9 1,3-DIMETHYLCYCLOHEXAN(ISOMERENGEMISCH) C8H16 112.21 CC1CC(C)CCC1 6876-23-9 TRANS-1,2-DIMETHYLCYCLOHEXAN C8H16 112.21 CC1CCCCC1C 1678-91-7 ETHYLCYCLOHEXAN C8H16 112.21 CCC1CCCCC1 3726-47-4 1-methyl-3-ethylcyclopentane C8H16 112.21 CCC(CC1)CC1C 292-64-8 CYCLOOCTAN C8H16 112.21 C1CCCCCCC1 4126-78-7 METHYLCYCLOHEPTAN C8H16 112.21 CC1CCCCCC1 471-44-3 chlorofluoroaceticacid C2H2ClFO2 112.49 FC(Cl)C(O)=O 71200-79-8 chlorofumaronitrile C4HClN2 112.52 ClC(C#N)=CC#N 108-90-7 CHLORBENZOL C6H5Cl 112.56 Clc1ccccc1 373-52-4 FLUORBROMMETHAN CH2BrF 112.93 FCBr 79-02-7 DICHLORACETALDEHYD C2H2Cl2O 112.94 ClC(Cl)C=O 79-04-9 CHLORESSIGSAEURECHLORID C2H2Cl2O 112.94 ClCC(Cl)=O 142-28-9 1,3-DICHLORPROPAN C3H6Cl2 112.99 ClCCCCl 78-87-5 1,2-DICHLORPROPAN C3H6Cl2 112.99 ClCC(C)Cl 78-99-9 1,1-DICHLORPROPAN C3H6Cl2 112.99 CCC(Cl)Cl 594-20-7 2,2-DICHLORPROPAN C3H6Cl2 112.99 CC(C)(Cl)Cl 354-38-1 2,2,2-TRIFLUORACETAMID C2H2F3NO 113.04 FC(F)(F)C(=O)N 609-39-2 2-NITROFURAN C4H3NO3 113.07 O=N(=O)c1occc1 3209-71-0 3-isoxazolecarboxylicacid C4H3NO3 113.07 OC(=O)c1nocc1 2730-67-8 2,2,2-trifluoro-n-meethylamine C3H6F3N 113.08 CNCC(F)(F)F 2075-46-9 4-nitropyrazole C3H3N3O2 113.08 O=N(=O)c1c[nH]nc1 88054-21-1 5-nitro-1h-imidazole C3H3N3O2 113.08 O=N(=O)c1[nH]cnc1 527-73-1 amicin C3H3N3O2 113.08 O=N(=O)c1[nH]ccn1 3034-38-6 4-NITRO-1H-IMIDAZOL C3H3N3O2 113.08 O=N(=O)c1c[nH]cn1 461-89-2 1,2,4-triazine-3,5(2h,4h)-dione C3H3N3O2 113.08 O=c1[nH]c([nH]nc1)=O

Page 31 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 71-33-0 5-azauracil C3H3N3O2 113.08 O=c1[nH]c([nH]cn1)=O 15657-96-2 2-(ACETYLOXY)PROPANNITRIL C5H7NO2 113.12 CC(OC(C)=O)C#N 105-56-6 2-CYANESSIGSAEUREETHYLESTER C5H7NO2 113.12 CCOC(CC#N)=O 4107-62-4 3-CYANPROPIONSAEUREMETHYLESTER C5H7NO2 113.12 COC(CCC#N)=O 1121-07-9 1-METHYL-2,5-PYRROLIDINDION C5H7NO2 113.12 CN1C(CCC1=O)=O 3775-61-9 2-nh2-5-et-1,3,4-oxadiazole C4H7N3O 113.12 CCc(nn1)oc1N 1121-89-7 2,6-PIPERIDINDION C5H7NO2 113.12 O=C1NC(CCC1)=O 60-27-5 2-AMINO-1,5-DIHYDRO-1-METHYL-4H-IMIDAZOL-4-ON C4H7N3O 113.12 CN1CC(=O)NC1=N 100-64-1 CYCLOHEXANONOXIM C6H11NO 113.16 ON=C1CCCCC1 820-99-5 cis2-hexenoicacidamide C6H11NO 113.16 CCCC=CC(=O)N 2591-86-8 1-PIPERIDINCARBOXALDEHYD C6H11NO 113.16 O=CN1CCCCC1 3317-61-1 dmpo C6H11NO 113.16 CC1(C)CCC=N1=O 5075-92-3 1,5-DIMETHYL-2-PYRROLIDON C6H11NO 113.16 CC1CCC(=O)N1C 3768-43-2 3-methyl-piperidin-2-one C6H11NO 113.16 CC1CCCNC1=O 2687-91-4 1-ETHYL-2-PYRROLIDON C6H11NO 113.16 CCN1CCCC1=O 105-60-2 HEXAHYDRO-2H-AZEPIN-2-ON C6H11NO 113.16 O=C1NCCCCC1 3386-97-8 3-BUTENYLISOTHIOCYANAT C5H7NS 113.18 C=CCCN=C=S 541-58-2 2,4-DIMETHYLTHIAZOL C5H7NS 113.18 Cc1nc(C)sc1 3581-91-7 4,5-dimethylthiazole C5H7NS 113.18 Cc1ncsc1C 4175-66-0 2,5-dimethyl-1,3-thiazole C5H7NS 113.18 Cc1sc(C)cn1 766-09-6 N-ETHYLPIPERIDIN C7H15N 113.20 CCN1CCCCC1 1121-92-2 OCTAHYDROAZOCIN C7H15N 113.20 N1CCCCCCC1 1193-12-0 3,3-DIMETHYLPIPERIDIN C7H15N 113.20 CC1(C)CCCNC1 35794-11-7 3,5-DIMETHYLPIPERIDIN C7H15N 113.20 CC1CC(C)CNC1 3230-23-7 4-ethylpiperidine C7H15N 113.20 CCC1CCNCC1 100-60-7 N-METHYLCYCLOHEXYLAMIN C7H15N 113.20 CNC1CCCCC1 1484-80-6 2-ETHYLPIPERIDIN C7H15N 113.20 CCC1CCCCN1 504-03-0 2,6-DIMETHYLPIPERIDIN C7H15N 113.20 CC1NC(C)CCC1 3218-02-8 cyclohexanemethylamine C7H15N 113.20 NCC1CCCCC1 109-09-1 2-CHLORPYRIDIN C5H4ClN 113.55 Clc1ccccn1 626-60-8 3-CHLORPYRIDIN C5H4ClN 113.55 Clc1cccnc1 626-61-9 4-CHLORPYRIDIN C5H4ClN 113.55 Clc1ccncc1 76-05-1 TRIFLUORESSIGSAEURE C2HF3O2 114.02 FC(F)(F)C(O)=O 2892-51-5 3,4-DIHYDROXY-3-CYCLOBUTEN-1,2-DION C4H2O4 114.06 Oc1c(=O)c(=O)c1O 120-89-8 IMIDAZOLIDINTRION C3H2N2O3 114.06 O=c([nH]c1=O)[nH]c1=O 2240-88-2 3,3,3-TRIFLUOR-1-PROPANOL C3H5F3O 114.07 OCCC(F)(F)F 374-01-6 1,1,1-TRIFLUOR-2-PROPANOL C3H5F3O 114.07 OC(C)C(F)(F)F 460-43-5 1,1,1-TRIFLUOR-2-METHOXYETHAN C3H5F3O 114.07 COCC(F)(F)F 540-36-3 1,4-DIFLUORBENZOL C6H4F2 114.09 Fc1ccc(F)cc1 372-18-9 1,3-DIFLUORBENZOL C6H4F2 114.09 Fc1cc(F)ccc1 367-11-3 1,2-DIFLUORBENZOL C6H4F2 114.09 Fc1ccccc1F 421-20-5 FLUORSCHWEFELSAEUREMETHYLESTER CH3FO3S 114.10 COS(F)(=O)=O 28873-61-2 1,3,4-oxadiazol-2(5h)-one,5,5-dimethyl- C4H6N2O2 114.10 CC1(C)N=NC(O1)=O 4427-96-7 4-ETHENYL-1,3-DIOXOLAN-2-ONE C5H6O3 114.10 C=CC1OC(OC1)=O 4100-80-5 METHYLBERNSTEINSAEUREANHYDRID C5H6O3 114.10 CC1CC(OC1=O)=O 2833-21-8 4-oxo-pent-2-enoicacid C5H6O3 114.10 OC(=O)C=CC(C)=O 108-55-4 DIHYDRO-2H-PYRAN-2,6(3H)-DION C5H6O3 114.10 O=C1OC(CCC1)=O 2763-96-4 muscimol C4H6N2O2 114.10 NCC1=CC(=O)NO1 106-57-0 2,5-DIKETOPIPERAZIN C4H6N2O2 114.10 O=C1NCC(=O)NC1 627-64-5 (2E)-2-BUTENDIAMID C4H6N2O2 114.10 O=C(N)C=CC(=O)N 123-20-6 BUTANSAEUREETHENYLESTER C6H10O2 114.14 CCCC(OC=C)=O 3400-45-1 CYCLOPENTANECARBONSAEURE C6H10O2 114.14 OC(C1CCCC1)=O 4454-05-1 2H-PYRAN,3,4-DIHYDRO-2-METHOXY- C6H10O2 114.14 COC1OC=CCC1 7493-58-5 4-methylpentane-2,3-dione C6H10O2 114.14 CC(C)C(=O)C(C)=O 1191-04-4 2-HEXENSAEURE C6H10O2 114.14 CCCC=CC(O)=O 3848-24-6 hexane-2,3-dione C6H10O2 114.14 CCCC(=O)C(C)=O 4437-51-8 3,4-hexanedione C6H10O2 114.14 CCC(=O)C(CC)=O 689-12-3 2-PROPENSAEURE-1-METHYLETHYLESTER C6H10O2 114.14 CC(C)OC(=O)C=C 925-60-0 2-PROPENSAEUREPROPYLESTER C6H10O2 114.14 CCCOC(=O)C=C 1577-18-0 (3E)-3-HEXENSAEURE C6H10O2 114.14 CCC=CCC(O)=O 2408-20-0 PROPANSAEURE-2-PROPENYLESTER C6H10O2 114.14 CCC(OCC=C)=O 1617-18-1 3-BUTENSAEUREETHYLESTER C6H10O2 114.14 CCOC(CC=C)=O

Page 32 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 924-50-5 3-methyl-2-butenoicacidmethylester C6H10O2 114.14 COC(=O)C=C(C)C 97-63-2 2-METHYL-2-PROPENSAEUREETHYLESTER C6H10O2 114.14 CCOC(=O)C(C)=C 1577-22-6 PENTEN-5-CARBONSAEURE C6H10O2 114.14 OC(CCCC=C)=O 6737-11-7 1-VINYLETHYLACETAT C6H10O2 114.14 CC(OC(C)=O)C=C 4606-07-9 CYCLOPROPANCARBONSAEUREETHYLESTER C6H10O2 114.14 CCOC(C1CC1)=O 628-08-0 2-BUTEN-1-OL,ACETATE C6H10O2 114.14 CC(OCC=CC)=O 6622-76-0 2-butenoicacid,2-methyl-,methylester,(e)- C6H10O2 114.14 COC(=O)C(C)=CC 10544-63-5 2-butenoicacid,ethylester C6H10O2 114.14 CCOC(=O)C=CC 623-70-1 2-BUTENSAEUREETHYLESTER C6H10O2 114.14 CCOC(=O)C=CC 3002-24-2 2,4-HEXANDION C6H10O2 114.14 CCC(CC(C)=O)=O 106-92-3 1-ALLYLOXY-2,3-EPOXYPROPAN C6H10O2 114.14 C=CCOCC1OC1 695-06-7 5-ETHYLDIHYDRO-2(3H)-FURANON C6H10O2 114.14 CCC1OC(CC1)=O 110-13-4 2,5-HEXANDION C6H10O2 114.14 CC(CCC(C)=O)=O 502-44-3 6-CAPROLACTON C6H10O2 114.14 O=C1CCCCCO1 823-22-3 6-METHYLVALEROLACTON C6H10O2 114.14 CC1OC(CCC1)=O 100-75-4 N-NITROSOPIPERIDIN C5H10N2O 114.15 O=NN1CCCCC1 80-73-9 1,3-DIMETHYL-2-IMIDAZOLIDINON C5H10N2O 114.15 CN1CCN(C)C1=O 28588-74-1 2-methylfuran-3-thiol C5H6OS 114.17 Cc1occc1S 16839-97-7 2-METHOXYTHIOPHEN C5H6OS 114.17 COc1sccc1 98-02-2 2-furanmethanethiol C5H6OS 114.17 CSc1occc1 636-72-6 2-(HYDROXYMETHYL)-THIOPHEN C5H6OS 114.17 OCc1sccc1 1603-91-4 2-AMINO-4-METHYLTHIAZOL C4H6N2S 114.17 Cc1nc(N)sc1 27464-82-0 1,3,4-thiadiazole,2,5-dimethyl- C4H6N2S 114.17 Cc1sc(C)nn1 60-56-0 1,3-DIHYDRO-1-METHYL-2H-IMIDAZOLE-2-THION C4H6N2S 114.17 CN1C=CNC1=S 97-93-8 TRIETHYLALUMINIUM C6H15Al 114.17 CC[Al](CC)CC 33467-76-4 2-hepten-1-ol,(e)- C7H14O 114.19 CCCCC=CCO 583-59-5 2-METHYLCYCLOHEXANOL C7H14O 114.19 OC1CCCCC1C 6191-71-5 (z)-hept-4-en-1-ol C7H14O 114.19 OCCCC=CCC 5454-79-5 (1R,3S)-REL-3-METHYLCYCLOHEXANOL C7H14O 114.19 OC1CC(C)CCC1 7731-29-5 TRANS-4-METHYLCYCLOHEXANOL C7H14O 114.19 OC1CCC(C)CC1 502-41-0 CYCLOHEPTANOL C7H14O 114.19 OC1CCCCCC1 590-67-0 METHYLCYCLOHEXANOL C7H14O 114.19 OC1(C)CCCCC1 591-23-1 3-METHYLCYCLOHEXANOL_(ISOMERENGEMISCH) C7H14O 114.19 OC1CC(C)CCC1 766-00-7 2-hydroxyethylcyclopentane C7H14O 114.19 OCCC1CCCC1 3521-91-3 1-hepten-4-ol C7H14O 114.19 CCCC(O)CC=C 925-54-2 HEXANAL,2-METHYL- C7H14O 114.19 CCCCC(C)C=O 7731-28-4 CIS-4-METHYLCYCLOHEXANOL C7H14O 114.19 OC1CCC(C)CC1 111-71-7 1-HEPTANAL C7H14O 114.19 CCCCCCC=O 19269-28-4 3-METHYLHEXANAL C7H14O 114.19 CCCC(C)CC=O 589-91-3 4-METHYLCYCLOHEXANOL_(ISOMERENGEMISCH) C7H14O 114.19 OC1CCC(C)CC1 590-50-1 4,4-DIMETHYL-2-PENTANON C7H14O 114.19 CC(C)(C)CC(C)=O 931-56-6 METHOXYCYLOHEXAN C7H14O 114.19 COC1CCCCC1 565-80-0 DIISOPROPYLKETON C7H14O 114.19 CC(C)C(C(C)C)=O 623-56-3 5-METHYL-3-HEXANON C7H14O 114.19 CC(C)CC(CC)=O 564-04-5 2,2-DIMETHYL-3-PENTANON C7H14O 114.19 CCC(C(C)(C)C)=O 106-35-4 3-HEPTANON C7H14O 114.19 CCCCC(CC)=O 123-19-3 4-HEPTANON C7H14O 114.19 CCCC(CCC)=O 105-42-0 4-METHYL-2-HEXANON C7H14O 114.19 CCC(C)CC(C)=O 22094-00-4 1-ethoxy-3-methylbut-2-ene C7H14O 114.19 CCOCC=C(C)C 110-12-3 5-METHYL-2-HEXANON C7H14O 114.19 CC(C)CCC(C)=O 7443-70-1 (1R,2S)-REL-2-METHYLCYCLOHEXANOL C7H14O 114.19 OC1CCCCC1C 110-43-0 2-HEPTANON C7H14O 114.19 CCCCCC(C)=O 100-49-2 CYCLOHEXANMETHANOL C7H14O 114.19 OCC1CCCCC1 106-58-1 N,N-DIMETHYLPIPERAZIN C6H14N2 114.19 CN1CCN(C)CC1 2815-34-1 TRANS-2,5-DIMETHYLPIPERAZIN C6H14N2 114.19 CC1NCC(C)NC1 694-83-7 1,2-CYCLOHEXANDIAMIN C6H14N2 114.19 NC1CCCCC1N 7154-73-6 1-pyrrolidineethanamine C6H14N2 114.19 NCCN1CCCC1 7144-05-0 4-piperidinemethanamine C6H14N2 114.19 NCC1CCNCC1 592-88-1 DIALLYLSULFID C6H10S 114.21 C=CCSCC=C 594-82-1 2,2,3,3-TETRAMETHYLBUTAN C8H18 114.23 CC(C)(C)C(C)(C)C 564-02-3 2,2,3-TRIMETHYLPENTAN C8H18 114.23 CCC(C)C(C)(C)C 560-21-4 2,3,3-TRIMETHYLPENTAN C8H18 114.23 CCC(C)(C)C(C)C

Page 33 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 540-84-1 2,2,4-TRIMETHYLPENTAN C8H18 114.23 CC(C)CC(C)(C)C 589-43-5 2,4-DIMETHYLHEXAN C8H18 114.23 CCC(C)CC(C)C 565-75-3 2,3,4-TRIMETHYLPENTAN C8H18 114.23 CC(C)C(C)C(C)C 1067-08-9 3-ETHYL-3-METHYLPENTAN C8H18 114.23 CCC(C)(CC)CC 563-16-6 3,3-DIMETHYLHEXAN C8H18 114.23 CCCC(C)(C)CC 592-13-2 2,5-DIMETHYLHEXAN C8H18 114.23 CC(C)CCC(C)C 590-73-8 2,2-DIMETHYLHEXAN C8H18 114.23 CCCCC(C)(C)C 609-26-7 3-ETHYL-2-METHYLPENTAN C8H18 114.23 CCC(CC)C(C)C 583-48-2 3,4-DIMETHYLHEXAN C8H18 114.23 CCC(C)C(C)CC 589-81-1 3-METHYLHEPTAN C8H18 114.23 CCCCC(C)CC 584-94-1 2,3-DIMETHYLHEXAN C8H18 114.23 CCCC(C)C(C)C 589-53-7 4-METHYLHEPTAN C8H18 114.23 CCCC(C)CCC 592-27-8 2-METHYLHEPTAN C8H18 114.23 CCCCCC(C)C 619-99-8 3-ETHYLHEXAN C8H18 114.23 CCCC(CC)CC 111-65-9 OCTAN C8H18 114.23 CCCCCCCC 762-72-1 TRIMETHYL-2-PROPENYLSILAN C6H14Si 114.26 C[Si](C)(C)CC=C 420-99-5 1-chloro-2,2-difluoropropane C3H5ClF2 114.52 ClCC(F)(F)C 14508-49-7 CHLORPYRAZIN C4H3ClN2 114.53 Clc1cnccn1 1722-12-9 pyrimidine,2-chloro- C4H3ClN2 114.53 Clc1ncccn1 124-63-0 METHANSULFONSAEURECHLORID CH3ClO2S 114.55 CS(Cl)(=O)=O 542-88-1 BIS-(CHLORMETHYL)-ETHER C2H4Cl2O 114.96 ClCOCCl 598-38-9 2,2-DICHLORETHANOL C2H4Cl2O 114.96 OCC(Cl)Cl 463-71-8 THIOKOHLENSAEUREDICHLORID CCl2S 114.98 ClC(Cl)=S 75-54-7 DICHLORMETHYLSILAN CH4Cl2Si 115.03 C[SiH](Cl)Cl 1513-65-1 2,6-difluoropyridine C5H3F2N 115.08 Fc1nc(F)ccc1 557-24-4 maleamicacid C4H5NO3 115.09 OC(=O)C=CC(=O)N 4394-85-8 4-MORPHOLINCARBOXALDEHYD C5H9NO2 115.13 O=CN1CCOCC1 1113-68-4 N-ACETYL-N-METHYLACETAMID C5H9NO2 115.13 CC(=O)N(C)C(C)=O 147-85-3 L-PYROLIDIN-2-CARBONSAEURE C5H9NO2 115.13 [O-]C(C1[NH2+]CCC1)=O 3433-37-2 2-PIPERIDINMETHANOL C6H13NO 115.17 OCC1CCCCN1 106-52-5 1-METHYL-4-PIPERIDINOL C6H13NO 115.17 OC1CCN(C)CC1 628-02-4 HEXANAMID C6H13NO 115.17 CCCCCC(=O)N 141-91-3 2,6-DIMETHYLMORPHOLIN C6H13NO 115.17 CC1OC(C)CNC1 1119-49-9 N-BUTYLACETAMID C6H13NO 115.17 CCCCNC(C)=O 100-74-3 4-ETHYLMORPHOLIN C6H13NO 115.17 CCN1CCOCC1 760-79-2 N,N-DIMETHYLBUTYRAMID C6H13NO 115.17 CCCC(=O)N(C)C 685-91-6 N,N-DIETHYLACETAMID C6H13NO 115.17 CCN(CC)C(C)=O 625-04-7 diacetonamine C6H13NO 115.17 NC(C)(C)CC(C)=O 80-70-6 1,1,3,3-TETRAMETHYLGUANIDIN C5H13N3 115.18 CN(C)C(=N)N(C)C 628-83-1 THIOCYANSAEUREBUTYLESTER C5H9NS 115.20 CCCCSC#N 10441-57-3 1-METHYL-2-PYRROLIDINTHION C5H9NS 115.20 CN1CCCC1=S 591-82-2 propane,1-isothiocyanato-2-methyl- C5H9NS 115.20 CC(C)CN=C=S 592-82-5 1-ISOTHIOCYANATOBUTAN C5H9NS 115.20 CCCCN=C=S 4426-79-3 2-isothiocyanatobutane C5H9NS 115.20 CCC(C)N=C=S 590-42-1 propane,2-isothiocyanato-2-methyl- C5H9NS 115.20 CC(C)(C)N=C=S 7515-80-2 2-METHYL-N-(1-METHYLETHYL)-2-PROPANAMIN C7H17N 115.22 CC(C)NC(C)(C)C 105-41-9 4-methyl-2-hexanamine C7H17N 115.22 CCC(C)CC(N)C 111-68-2 1-AMINOHEPTAN C7H17N 115.22 NCCCCCCC 123-82-0 2-HEPTANAMIN C7H17N 115.22 CCCCCC(N)C 13863-41-7 BROMCHLORID BrCl 115.36 ClBr 354-34-7 TRIFLUORACETYLFLUORID C2F4O 116.01 FC(F)(F)C(F)=O 110-17-8 (2E)-BUTENDISAEURE C4H4O4 116.07 OC(=O)C=CC(O)=O 110-16-7 (2Z)-2-BUTENDISAEURE C4H4O4 116.07 OC(=O)C=CC(O)=O 502-97-6 1,4-DIOXAN-2,5-DION C4H4O4 116.07 O=C1OCC(OC1)=O 24331-09-7 METHANTETRACARBONITRIL C5N4 116.08 N#CC(C#N)(C#N)C#N 123-77-3 DIAZENDICARBOXAMID C2H4N4O2 116.08 O=C(N)N=NC(=O)N 759-05-7 3-methyl-2-oxobutanoicacid C5H8O3 116.12 CC(C)C(=O)C(O)=O 617-35-6 BRENZTRAUBENSAEUREETHYLESTER C5H8O3 116.12 CCOC(=O)C(C)=O 818-61-1 2-PROPENSAEURE-2-HYDROXYETHYLESTER C5H8O3 116.12 OCCOC(=O)C=C 16874-33-2 2-furancarboxylicacid,tetrahydro- C5H8O3 116.12 OC(C1CCCO1)=O 105-45-3 ACETESSIGSAEUREMETHYLESTER C5H8O3 116.12 COC(CC(C)=O)=O 592-20-1 1-(ACETYLOXY)-2-PROPANON C5H8O3 116.12 CC(OCC(C)=O)=O

Page 34 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 95-45-4 DIACETYLDIOXIM C4H8N2O2 116.12 ON=C(C)C(C)=NO 59-89-2 4-nitroso-morpholine C4H8N2O2 116.12 O=NN1CCOCC1 123-76-2 4-KETOVALERIANSAEURE C5H8O3 116.12 OC(CCC(C)=O)=O 623-59-6 n-(methylamino)carbonylacetamide C4H8N2O2 116.12 CNC(=O)NC(C)=O 3148-73-0 1,2-diacetylhydrazine C4H8N2O2 116.12 CC(=O)NNC(C)=O 2620-63-5 N-(2-AMINO-2-OXOETHYL)ACETAMID C4H8N2O2 116.12 CC(=O)NCC(=O)N 110-14-5 BUTANDIAMID C4H8N2O2 116.12 O=C(CCC(=O)N)N 595-37-9 2,2-DIMETHYLBUTANSAEURE C6H12O2 116.16 CCC(C)(C)C(O)=O 766-07-4 CYCLOHEXYLHYDROPEROXID C6H12O2 116.16 OOC1CCCCC1 97-61-0 2-METHYLPENTANSAEURE C6H12O2 116.16 CCCC(C)C(O)=O 88-09-5 2-ETHYLBUTANSAEURE C6H12O2 116.16 CCC(CC)C(O)=O 105-43-1 3-METHYLVALERIANSAEURE C6H12O2 116.16 CCC(C)CC(O)=O 142-62-1 HEXANSAEURE C6H12O2 116.16 CCCCCC(O)=O 1070-83-3 3,3-DIMETHYLBUTANSAEURE C6H12O2 116.16 CC(C)(C)CC(O)=O 646-07-1 4-METHYLPENTANSAEURE C6H12O2 116.16 CC(C)CCC(O)=O 1460-57-7 TRANS-1,2-CYCLOHEXANDIOL C6H12O2 116.16 OC1CCCCC1O 638-49-3 AMEISENSAEUREPENTYLESTER C6H12O2 116.16 CCCCCOC=O 110-45-2 3-METHYL-1-BUTANOLFORMIAT C6H12O2 116.16 CC(C)CCOC=O 1792-81-0 CIS-1,2-CYCLOHEXANDIOL C6H12O2 116.16 OC1CCCCC1O 598-98-1 2,2-DIMETHYLPROPANSAEUREMETHYLESTER C6H12O2 116.16 COC(C(C)(C)C)=O 624-24-8 PENTANSAEUREMETHYLESTER C6H12O2 116.16 CCCCC(OC)=O 556-24-1 3-METHYLBUTANSAEUREMETHYLESTER C6H12O2 116.16 CC(C)CC(OC)=O 97-62-1 2-METHYLPROPANSAEUREETHYLESTER C6H12O2 116.16 CCOC(C(C)C)=O 105-54-4 BUTANSAEUREETHYLESTER C6H12O2 116.16 CCOC(CCC)=O 637-78-5 PROPANSAEURE-1-METHYLETHYLESTER C6H12O2 116.16 CC(C)OC(CC)=O 106-36-5 PROPANSAEUREPROPYLESTER C6H12O2 116.16 CCCOC(CC)=O 540-88-5 ESSIGSAEURE-1,1-DIMETHYLETHYLESTER C6H12O2 116.16 CC(C)(C)OC(C)=O 123-86-4 ESSIGSAEUREBUTYLESTER C6H12O2 116.16 CCCCOC(C)=O 110-19-0 ESSIGSAEURE-2-METHYLPROPYLESTER C6H12O2 116.16 CC(C)COC(C)=O 105-46-4 2-BUTYLACETAT C6H12O2 116.16 CCC(C)OC(C)=O 52458-04-5 ETHANOL,2-(2-BUTENYLOXY)- C6H12O2 116.16 OCCOCC=CC 1193-11-9 2,2,4-trimethyl-1,3-dioxolane C6H12O2 116.16 CC(CO1)OC1(C)C 100-72-1 2-(HYDROXYMETHYL)-TETRAHYDROPYRAN C6H12O2 116.16 OCC1CCCCO1 100524-60-5 ETHANOL,2-[(1-METHYL-2-PROPENYL)OXY]- C6H12O2 116.16 OCCOC(C)C=C 21460-36-6 2-PROPANOL,1-(2-PROPENYLOXY)- C6H12O2 116.16 OC(C)COCC=C 766-20-1 2,4-DIMETHYL-1,3-DIOXAN C6H12O2 116.16 CC1OC(C)CCO1 623-76-7 1,3-DIETHYLHARNSTOFF C5H12N2O 116.16 CCNC(=O)NCC 19354-27-9 methyltetrahydrofurfurylether C6H12O2 116.16 COCC1CCCO1 123-42-2 4-HYDROXY-4-METHYL-2-PENTANON C6H12O2 116.16 OC(C)(C)CC(C)=O 1118-12-3 (1,1-DIMETHYLETHYL)HARNSTOFF C5H12N2O 116.16 CC(C)(C)NC(=O)N 592-31-4 BUTYLHARNSTOFF C5H12N2O 116.16 CCCCNC(=O)N 592-17-6 ISOBUTYLHARNSTOFF C5H12N2O 116.16 CC(C)CNC(=O)N 632-22-4 TETRAMETHYLHARNSTOFF C5H12N2O 116.16 CN(C)C(=O)N(C)C 634-95-7 N,N-DIETHYLHARNSTOFF C5H12N2O 116.16 CCN(CC)C(=O)N 689-11-2 N-SEK.-BUTYLHARNSTOFF C5H12N2O 116.16 CCC(C)NC(=O)N 673-32-5 1-PROPINYLBENZOL C9H8 116.16 CC#Cc1ccccc1 95-13-6 1H-INDEN C9H8 116.16 C(C=Cc1cc2)c1cc2 13679-85-1 2-methylthiolan-3-one C5H8OS 116.18 CC1SCCC1=O 1072-72-6 TETRAHYDRO-4H-THIOPYRAN-4-ON C5H8OS 116.18 O=C1CCSCC1 2055-46-1 n,n'-trimethylenethiourea C4H8N2S 116.19 S=C1NCCCN1 109-57-9 allylthiourea C4H8N2S 116.19 C=CCNC(N)=S 625-06-9 2,4-DIMETHYL-2-PENTANOL C7H16O 116.20 CC(C)CC(O)(C)C 627-59-8 5-METHYL-2-HEXANOL C7H16O 116.20 OC(C)CCC(C)C 600-36-2 2,4-DIMETHYL-3-PENTANOL C7H16O 116.20 CC(C)C(O)C(C)C 595-41-5 2,3-DIMETHYL-3-PENTANOL C7H16O 116.20 CCC(O)(C)C(C)C 4747-07-3 1-METHOXYHEXAN C7H16O 116.20 COCCCCCC 3073-92-5 1-PROPOXYBUTAN C7H16O 116.20 CCCOCCCC 625-23-0 2-METHYL-2-HEXANOL C7H16O 116.20 CCCCC(O)(C)C 543-49-7 2-HEPTANOL C7H16O 116.20 CCCCCC(O)C 594-83-2 2,3,3-TRIMETHYL-2-BUTANOL C7H16O 116.20 OC(C)(C)C(C)(C)C 1860-27-1 ISOPROPYLBUTYLETHER C7H16O 116.20 CCCCOC(C)C 78448-33-6 ISOPROPYLISOBUTYLETHER C7H16O 116.20 CC(C)OCC(C)C

Page 35 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 627-98-5 5-METHYL-1-HEXANOL C7H16O 116.20 OCCCCC(C)C 3970-62-5 2,2-DIMETHYL-3-PENTANOL C7H16O 116.20 CCC(O)C(C)(C)C 597-96-6 3-METHYL-3-HEXANOL C7H16O 116.20 CCCC(O)(C)CC 111-70-6 1-HEPTANOL C7H16O 116.20 OCCCCCCC 589-55-9 4-HEPTANOL C7H16O 116.20 CCCC(O)CCC 597-49-9 3-ETHYL-3-PENTANOL C7H16O 116.20 CCC(O)(CC)CC 589-82-2 3-HEPTANOL C7H16O 116.20 CCCCC(O)CC 617-29-8 2-METHYL-3-HEXANOL C7H16O 116.20 CCCC(O)C(C)C 919-94-8 2-ETHOXY-2-METHYLBUTAN C7H16O 116.20 CCOC(C)(C)CC 624-22-6 2-METHYL-1-HEXANOL C7H16O 116.20 CCCCC(C)CO 7774-74-5 thiophene-2-thiol C4H4S2 116.21 Sc1sccc1 3711-34-0 1,2-bis(1-methylethyl)hydrazine C6H16N2 116.21 CC(C)NNC(C)C 110-18-9 N,N,N`,N`-TETRAMETHYLETHYLENDIAMIN C6H16N2 116.21 CN(C)CCN(C)C 111-74-0 n,n'-diethyl-1,2-ethanediamine C6H16N2 116.21 CCNCCNCC 123-83-1 1,2-ethanediamine,n'-ethyl-n,n-dimethyl- C6H16N2 116.21 CCNCCN(C)C 100-36-7 2-DIETHYLAMINOETHYLAMIN C6H16N2 116.21 NCCN(CC)CC 124-09-4 1,6-HEXANDIAMIN C6H16N2 116.21 NCCCCCCN 1551-32-2 2-ETHYL-2,3,4,5-TETRAHYDROTHIOPHEN C6H12S 116.23 CCC1SCCC1 1569-69-3 CYCLOHEXANTHIOL C6H12S 116.23 SC1CCCCC1 1001-52-1 BUTYLDIMETHYLSILAN C6H16Si 116.28 CCCC[SiH](C)C 617-86-7 TRIETHYLSILAN C6H16Si 116.28 CC[SiH](CC)CC 3510-70-1 TRIMETHYLPROPYLSILAN C6H16Si 116.28 CCC[Si](C)(C)C 79-38-9 1-CHLOR-1,2,2-TRIFLUORETHYLEN C2ClF3 116.47 FC(F)=C(F)Cl 7790-94-5 CHLORSCHWEFELSAEURE HClO3S 116.52 OS(Cl)(=O)=O 930-66-5 1-chlorocyclohexene C6H9Cl 116.59 ClC1=CCCCC1 430-57-9 1,2-DICHLOR-1-FLUORETHAN C2H3Cl2F 116.95 ClCC(F)Cl 1717-00-6 1,1-DICHLOR-1-FLUORETHAN C2H3Cl2F 116.95 FC(C)(Cl)Cl 543-24-8 N-ACETYLGLYCIN C4H7NO3 117.10 OC(=O)CNC(C)=O 759-73-9 n-ethyl-n-nitrosourea C3H7N3O2 117.11 CCN(N=O)C(=O)N 352-97-6 glycocyamine C3H7N3O2 117.11 OC(=O)CNC(=N)N 2295-31-0 2,4-thiazolidinedione C3H3NO2S 117.13 O=C1NC(SC1)=O 628-05-7 1-NITROPENTAN C5H11NO2 117.15 CCCCCN(=O)=O 274-40-8 indolizine C8H7N 117.15 c2cc1cccn1cc2 620-22-4 3-CYANOTOLUOL C8H7N 117.15 Cc1cc(C#N)ccc1 529-19-1 2-CYANOTOLUOL C8H7N 117.15 Cc1ccccc1C#N 104-85-8 4-CYANOTOLUOL C8H7N 117.15 Cc1ccc(C#N)cc1 543-28-2 CARBAMIDSAEURE-2-METHYLPROPYLESTER C5H11NO2 117.15 CC(C)COC(=O)N 592-35-8 BUTYLCARBAMAT C5H11NO2 117.15 CCCCOC(=O)N 4248-19-5 o-t-butylcarbamate C5H11NO2 117.15 CC(C)(C)OC(=O)N 623-78-9 N-ETHYL-ETHYLCARBAMAT C5H11NO2 117.15 CCOC(=O)NCC 140-29-4 BENZYLCYANID C8H7N 117.15 N#CCc1ccccc1 120-72-9 1H-INDOL C8H7N 117.15 c2cc1cc[nH]c1cc2 110-46-3 ISOAMYLNITRIT C5H11NO2 117.15 CC(C)CCON=O 463-04-7 N-AMYLNITRIT C5H11NO2 117.15 CCCCCON=O 595-39-1 dl-isovaline C5H11NO2 117.15 CCC(C)([NH3+])C([O-])=O 72-18-4 2-AMINO-3-METHYLBUTTERSAEURE C5H11NO2 117.15 CC(C)C([NH3+])C([O-])=O 498-18-0 norvaline C5H11NO2 117.15 CCCC([NH3+])C([O-])=O 660-88-8 5-AMINOPENTANSAEURE C5H11NO2 117.15 [NH3+]CCCCC([O-])=O 10294-34-5 TRICHLORBORAN BCl3 117.17 ClB(Cl)Cl 111-75-1 N-BUTYLETHANOLAMIN C6H15NO 117.19 OCCNCCCC 100-37-8 N,N-DIETHYLETHANOLAMIN C6H15NO 117.19 OCCN(CC)CC 4620-70-6 TERT.-BUTYLETHANOLAMIN C6H15NO 117.19 OCCNC(C)(C)C 4048-33-3 1-HEXANOL,6-AMINO- C6H15NO 117.19 OCCCCCCN 2083-91-2 PENTAMETHYLSILANAMIN C5H15NSi 117.27 CN(C)[Si](C)(C)C 18135-04-1 ethanamine,2-(trimethylsilyl)- C5H15NSi 117.27 NCC[Si](C)(C)C 1691-17-4 OXYBIS(DIFLUORMETHAN) C2H2F4O 118.03 FC(F)OC(F)F 110-22-5 peroxide,diacetyl C4H6O4 118.09 CC(OOC(C)=O)=O 553-90-2 ETHANDISAEUREDIMETHYLESTER C4H6O4 118.09 COC(=O)C(OC)=O 629-15-2 ETHYLENGLYKOLDIFORMIAT C4H6O4 118.09 O=COCCOC=O 516-05-2 METHYLPROPANDISAEURE C4H6O4 118.09 CC(C(O)=O)C(O)=O 13831-30-6 ACETICACID,(ACETYLOXY) C4H6O4 118.09 OC(COC(C)=O)=O 110-15-6 BUTANDISAEURE C4H6O4 118.09 OC(CCC(O)=O)=O

Page 36 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 13256-22-9 n-nitrososarcosine C3H6N2O3 118.09 OC(=O)CN(C)N=O 931-40-8 4-(HYDROXYMETHYL)-1,3-DIOXOLAN-2-ON C4H6O4 118.09 OCC1OC(OC1)=O 996-98-5 ETHANDISAEUREDIHYDRAZID C2H6N4O2 118.09 NNC(=O)C(=O)NN 110-21-4 1,2-HYDRAZINDICARBOXAMID C2H6N4O2 118.09 O=C(N)NNC(=O)N 617-31-2 2-hydroxypentanoicacid C5H10O3 118.13 CCCC(O)C(O)=O 105-58-8 DIETHYLCARBONAT C5H10O3 118.13 CCOC(OCC)=O 271-89-6 BENZOFURAN C8H6O 118.13 c2cc1ccoc1cc2 97-64-3 2-HYDROXYPROPANSAEUREETHYLESTER C5H10O3 118.13 CCOC(C(O)C)=O 2110-78-3 2-HYDROXY-2-METHYLPROPANSAEUREMETHYLESTER C5H10O3 118.13 COC(C(O)(C)C)=O 625-08-1 3-hydroxy-3-methylbutanoicacid C5H10O3 118.13 OC(C)(C)CC(O)=O 3852-09-3 3-METHOXYPROPANSAEUREMETHYLESTER C5H10O3 118.13 COCCC(OC)=O 110-49-6 2-METHOXYETHANOLACETAT C5H10O3 118.13 COCCOC(C)=O 3938-96-3 2-METHOXYESSIGSAEUREETHYLESTER C5H10O3 118.13 COCC(OCC)=O 274-55-5 7-azaindole C7H6N2 118.14 c2cc1cc[nH]c1nc2 271-44-3 1H-INDAZOL C7H6N2 118.14 c2cc1cn[nH]c1cc2 271-29-4 6-azaindole C7H6N2 118.14 c2cc1cc[nH]c1cn2 1885-29-6 benzonitrile,2-amino- C7H6N2 118.14 Nc1ccccc1C#N 271-34-1 5-azaindole C7H6N2 118.14 n2cc1cc[nH]c1cc2 272-49-1 4-azaindole C7H6N2 118.14 c2nc1cc[nH]c1cc2 2237-30-1 3-AMINOBENZONITRIL C7H6N2 118.14 Nc1cc(C#N)ccc1 51-17-2 1H-BENZIMIDAZOL C7H6N2 118.14 c2cc1nc[nH]c1cc2 873-74-5 4-AMINOBENZONITRIL C7H6N2 118.14 Nc1ccc(C#N)cc1 554-70-1 TRIETHYLPHOSPHIN C6H15P 118.16 CCP(CC)CC 77-77-0 DIVINYLSULFON C4H6O2S 118.16 C=CS(=O)(=O)C=C 591-08-2 1-acetyl-2-thiourea C3H6N2OS 118.16 CC(=O)NC(S)=N 77-79-2 2,5-DIHYDROTHIOPHEN-1,1-DIOXID C4H6O2S 118.16 O=S1(CC=CC1)=O 1192-16-1 4,5-DIHYDROTHIOPHEN-1,1-DIOXID C4H6O2S 118.16 O=S1(=O)C=CCC1 6920-22-5 1,2-HEXANDIOL C6H14O2 118.17 CCCCC(O)CO 149-31-5 1,3-PENTANEDIOL,2-METHYL C6H14O2 118.17 OCC(C)C(O)CC 76-09-5 2,3-DIMETHYL-2,3-BUTANDIOL C6H14O2 118.17 OC(C)(C)C(O)(C)C 19780-90-6 2,4-HEXANDIOL C6H14O2 118.17 CCC(O)CC(O)C 2935-44-6 2,5-HEXANDIOL C6H14O2 118.17 OC(C)CCC(O)C 928-40-5 1,5-HEXANDIOL C6H14O2 118.17 OCCCCC(O)C 107-41-5 2-METHYL-2,4-PENTANDIOL C6H14O2 118.17 OC(C)CC(O)(C)C 629-11-8 1,6-HEXANDIOL C6H14O2 118.17 OCCCCCCO 111-76-2 2-BUTOXYETHANOL C6H14O2 118.17 OCCOCCCC 105-57-7 1,1-DIETHOXYETHAN C6H14O2 118.17 CCOC(C)OCC 1569-01-3 1-PROPOXY-2-PROPANOL C6H14O2 118.17 CCCOCC(O)C 7580-85-0 ETHYLENGLYCOLMONO-TERT-BUTYLETHER C6H14O2 118.17 OCCOC(C)(C)C 3944-36-3 2-PROPANOL,1-ISOPROPOXY- C6H14O2 118.17 OC(C)COC(C)C 629-14-1 1,2-DIETHOXYETHAN C6H14O2 118.17 CCOCCOCC 56539-66-3 3-methyl-3-methoxybutanol C6H14O2 118.17 OCCC(C)(C)OC 2314-40-1 1,3-dithiol-2-one C3H2OS2 118.18 O=C1SC=CS1 873-49-4 CYCLOPROPYLBENZOL C9H10 118.18 C1CC1c2ccccc2 300-57-2 2-PROPENYLBENZOL C9H10 118.18 C=CCc1ccccc1 637-50-3 PROPENYLBENZOL C9H10 118.18 CC=Cc1ccccc1 873-66-5 (1E)-1-PROPENYLBENZOL C9H10 118.18 CC=Cc1ccccc1 622-97-9 4-METHYLSTYROL C9H10 118.18 Cc1ccc(C=C)cc1 100-80-1 1-ETHENYL-3-METHYLBENZOL C9H10 118.18 Cc1cc(C=C)ccc1 611-15-4 1-ETHENYL-2-METHYLBENZOL C9H10 118.18 Cc1ccccc1C=C 98-83-9 2-PHENYL-1-PROPEN C9H10 118.18 CC(=C)c1ccccc1 766-90-5 (1Z)-1-PROPENYLBENZOL C9H10 118.18 CC=Cc1ccccc1 496-11-7 2,3-DIHYDRO-1H-INDEN C9H10 118.18 C(Cc1cc2)Cc1cc2 661-11-0 1-FLUORHEPTAN C7H15F 118.19 FCCCCCCC 67633-97-0 3-sulfanylpentan-2-one C5H10OS 118.20 CCC(S)C(C)=O 16630-52-7 3-methylsulfanylbutanal C5H10OS 118.20 CSC(C)CC=O 42919-64-2 4-methylsulfanylbutanal C5H10OS 118.20 CSCCCC=O 13678-58-5 1-methylsulfanylbutan-2-one C5H10OS 118.20 CSCC(CC)=O 53475-15-3 3-methylsulfanylbutan-2-one C5H10OS 118.20 CSC(C)C(C)=O 57124-87-5 2-methyloxolane-3-thiol C5H10OS 118.20 CC1OCCC1S 34047-39-7 4-methylsulfanylbutan-2-one C5H10OS 118.20 CSCCC(C)=O 2489-77-2 trimethylthiourea C4H10N2S 118.20 CNC(=S)N(C)C

Page 37 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 14290-92-7 2-(ETHYLTHIO)-2-METHYLPROPAN C6H14S 118.24 CCSC(C)(C)C 625-80-9 DIISOPROPYLTHIOETHER C6H14S 118.24 CC(C)SC(C)C 5008-73-1 1-((1-METHYLETHYL)THIO)PROPAN C6H14S 118.24 CCCSC(C)C 638-46-0 1-(ETHYLTHIO)BUTAN C6H14S 118.24 CCCCSCC 111-47-7 DIPROPYLSULFID C6H14S 118.24 CCCSCCC 1741-83-9 1-(METHYLTHIO)PENTAN C6H14S 118.24 CCCCCSC 13286-92-5 3,3-DIMETHYL-2-THIAPENTAN C6H14S 118.24 CCC(C)(C)SC 111-31-9 1-HEXANTHIOL C6H14S 118.24 CCCCCCS 1613-45-2 1-(ETHYLTHIO)-2-METHYLPROPAN C6H14S 118.24 CCSCC(C)C 1679-06-7 2-HEXANTHIOL C6H14S 118.24 CCCCC(C)S 1825-62-3 TRIMETHYLETHOXYSILAN C5H14OSi 118.25 CCO[Si](C)(C)C 431-07-2 1-CHLOR-1,2,2-TRIFLUORETHAN C2H2ClF3 118.49 FC(F)C(F)Cl 75-88-7 2-CHLOR-1,1,1-TRIFLUORETHAN C2H2ClF3 118.49 ClCC(F)(F)F 3350-78-5 3-methyl-but-2-enoylchloride C5H7ClO 118.56 CC(C)=CC(Cl)=O 17249-80-8 3-chlorothiophene C4H3ClS 118.59 Clc1cscc1 96-43-5 2-CHLORTHIOPHEN C4H3ClS 118.59 Clc1sccc1 542-18-7 CHLORCYCLOHEXAN C6H11Cl 118.61 ClC1CCCCC1 106-96-7 METHYLBROMETHIN C3H3Br 118.96 BrCC#C 7719-09-7 THIONYLCHLORID Cl2OS 118.97 ClS(Cl)=O 622-37-7 AZIDOBENZOL C6H5N3 119.12 N#N=Nc1ccccc1 76-39-1 2-METHYL-2-NITRO-1-PROPANOL C4H9NO3 119.12 OCC(C)(C)N(=O)=O 609-31-4 2-nitro-1-butanol C4H9NO3 119.12 OCC(CC)N(=O)=O 271-95-4 1,2-benzisoxazole C7H5NO 119.12 c2cc1cnoc1cc2 271-58-9 benzisoxazole C7H5NO 119.12 c2cc1nocc1cc2 273-53-0 1-OXA-3-AZA-1H-INDOL C7H5NO 119.12 c2cc1ncoc1cc2 611-20-1 2-HYDROXYBENZONITRIL C7H5NO 119.12 Oc1ccccc1C#N 873-62-1 3-HYDROXYBENZONITRIL C7H5NO 119.12 Oc1cc(C#N)ccc1 767-00-0 4-HYDROXYBENZONITRIL C7H5NO 119.12 Oc1ccc(C#N)cc1 95-14-7 1H-BENZOTRIAZOL C6H5N3 119.12 c2cc1nn[nH]c1cc2 272-97-9 3,5-diazaindole C6H5N3 119.12 n2cc1nc[nH]c1cc2 1927-25-9 dl-homoserine C4H9NO3 119.12 OCCC(N)C(O)=O 672-15-1 l-homoserine C4H9NO3 119.12 OCCC(N)C(O)=O 273-21-2 1h-imidazo[4,5-b]pyridine C6H5N3 119.12 c2nc1nc[nH]c1cc2 103-71-9 ISOCYANATOBENZOL C7H5NO 119.12 O=C=Nc1ccccc1 928-45-0 SALPETERSAEUREBUTYLESTER C4H9NO3 119.12 CCCCON(=O)=O 543-29-3 SALPETERSAEURE-2-METHYLPROPYLESTER C4H9NO3 119.12 CCC(C)ON(=O)=O 924-52-7 nitricacid,1-methylpropylester C4H9NO3 119.12 CCC(C)ON(=O)=O 72-19-5 L-THREONIN C4H9NO3 119.12 OC(C)C([NH3+])C([O-])=O 2274-42-2 methylsulfonylacetonitrile C3H5NO2S 119.14 N#CCS(C)(=O)=O 496-15-1 2,3-DIHYDRO-1H-INDOL C8H9N 119.16 C(Nc1cc2)Cc1cc2 622-29-7 N-(PHENYLMETHYLEN)METHANAMIN C8H9N 119.16 CN=Cc1ccccc1 1520-21-4 benzenamine,4-ethenyl- C8H9N 119.16 Nc1ccc(C=C)cc1 115-70-8 2-AMINO-2-ETHYL-1,3-PROPANEDIOL(AEPD) C5H13NO2 119.16 OCC(N)(CO)CC 95-11-4 5-norbornene-2-carbonitrile C8H9N 119.16 N#CC2CC1C=CC2C1 105-59-9 N-METHYLDIETHANOLAMIN C5H13NO2 119.16 OCCN(C)CCO 140-76-1 5-ETHENYL-2-METHYLPYRIDIN C8H9N 119.16 Cc1ccc(C=C)cn1 122-07-6 ethanamine,2,2-dimethoxy-n-methyl- C5H13NO2 119.16 CNCC(OC)OC 6926-58-5 4,4-dimethylthiosemicarbazide C3H9N3S 119.19 CN(C)C(=S)NN 67-66-3 TRICHLORMETHAN CHCl3 119.38 ClC(Cl)Cl 4461-30-7 chloroacetylisocyanate C3H2ClNO2 119.51 ClCC(=O)N=C=O 354-33-6 PENTAFLUORETHAN C2HF5 120.02 FC(F)C(F)(F)F 593-88-4 TRIMETHYLARSIN C3H9As 120.03 C[As](C)C 80-69-3 tartronicacid C3H4O5 120.06 OC(C(O)=O)C(O)=O 293-30-1 1,3,5,7-TETROXAN C4H8O4 120.10 C1OCOCOCO1 583-50-6 d-erythrose C4H8O4 120.10 OCC(O)C(O)C=O 273-59-6 1,2,3-BENZOXADIAZOL C6H4N2O 120.11 c(ccc1on2)cc1n2 273-09-6 2,1,3-BENZOXADIAZOL C6H4N2O 120.11 c(ccc1no2)cc1n2 271-80-7 1h-pyrazolo[3,4-d]pyrimidine C5H4N4 120.11 n2cc1cn[nH]c1nc2 140-95-4 1,3-BIS(HYDROXYMETHYL)-HARNSTOFF C3H8N2O3 120.11 OCNC(=O)NCO 496-16-2 2,3-DIHYDROBENZOFURAN C8H8O 120.15 C(Oc1cc2)Cc1cc2 96-09-3 PHENYLOXIRAN C8H8O 120.15 C1OC1c2ccccc2 620-23-5 3-METHYLBENZALDEHYD C8H8O 120.15 Cc1cc(C=O)ccc1

Page 38 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 529-20-4 2-METHYLBENZALDEHYD C8H8O 120.15 Cc1ccccc1C=O 122-78-1 BENZOLACETALDEHYD C8H8O 120.15 O=CCc1ccccc1 104-87-0 4-METHYLBENZALDEHYD C8H8O 120.15 Cc1ccc(C=O)cc1 1445-45-0 1,1,1-TRIMETHOXYETHAN C5H12O3 120.15 COC(C)(OC)OC 98-86-2 1-PHENYLETHANON C8H8O 120.15 CC(=O)c1ccccc1 496-14-0 2,5-DIHYDROBENZO-3,4-FURAN C8H8O 120.15 O(Cc1cc2)Cc1cc2 623-69-8 GLYCERIN-1,3-DIMETHYLETHER C5H12O3 120.15 COCC(O)COC 38713-41-6 2-prop-1-en-2-ylpyrazine C7H8N2 120.15 CC(=C)c1cnccn1 13925-08-1 2-ethenyl-5-methylpyrazine C7H8N2 120.15 Cc1cnc(C=C)cn1 77-85-0 1,1,1-TRIMETHYLOLETHAN C5H12O3 120.15 OCC(C)(CO)CO 111-77-3 2-(2-METHOXYETHOXY)ETHANOL C5H12O3 120.15 COCCOCCO 2628-17-3 PHENOL,4-ETHENYL C8H8O 120.15 Oc1ccc(C=C)cc1 1670-14-0 benzamidine C7H8N2 120.15 N=C(c1ccccc1)N 766-94-9 (ETHENYLOXY)BENZOL C8H8O 120.15 C=COc1ccccc1 623-51-8 aceticacid,mercapto-,ethylester C4H8O2S 120.17 CCOC(CS)=O 2935-90-2 METHYLESTER3-MERCAPTO-PROPANOICACID C4H8O2S 120.17 SCCC(OC)=O 627-04-3 aceticacid,(ethylthio)- C4H8O2S 120.17 CCSCC(O)=O 126-33-0 SULFOLAN C4H8O2S 120.17 O=S1(CCCC1)=O 2396-65-8 1,8-NONADIIN C9H12 120.19 C#CCCCCCC#C 2080-58-2 1,3-DITHIOLAN-2-ON C3H4OS2 120.19 O=C1SCCS1 526-73-8 1,2,3-TRIMETHYLBENZOL C9H12 120.19 Cc1cccc(C)c1C 611-14-3 2-ETHYLTOLUOL C9H12 120.19 CCc1ccccc1C 95-63-6 1,2,4-TRIMETHYLBENZOL C9H12 120.19 Cc(ccc1C)cc1C 98-82-8 (1-METHYLETHYL)BENZOL C9H12 120.19 CC(C)c1ccccc1 103-65-1 PROPYLBENZOL C9H12 120.19 CCCc1ccccc1 620-14-4 3-ETHYLTOLUOL C9H12 120.19 CCc(ccc1)cc1C 622-96-8 4-ETHYLTOLUOL C9H12 120.19 CCc(cc1)ccc1C 108-67-8 1,3,5-TRIMETHYLBENZOL C9H12 120.19 Cc1cc(C)cc(C)c1 3048-64-4 5-ETHENYLBICYCLO(2.2.1)HEPT-2-EN C9H12 120.19 C=CC2CC1C=CC2C1 16219-75-3 5-ETHYLIDENBICYCLO(2.2.1)HEPT-2-EN C9H12 120.19 CC=C2CC1C=CC2C1 79-40-3 DITHIOOXAMID C2H4N2S2 120.20 NC(=S)C(N)=S 20582-85-8 4-methylsulfanylbutan-1-ol C5H12OS 120.21 OCCCCSC 34300-94-2 3-methyl-3-sulfanylbutan-1-ol C5H12OS 120.21 OCCC(C)(C)S 1112-39-6 DIMETHOXYDIMETHYLSILAN C4H12O2Si 120.22 CO[Si](C)(C)OC 5616-51-3 2-methyl-1,3-dithiolane C4H8S2 120.24 CC1SCCS1 505-29-3 1,4-DITHIAN C4H8S2 120.24 S1CCSCC1 505-23-7 1,3-DITHIAN C4H8S2 120.24 C1CSCSC1 2179-58-0 3-methyldisulfanylprop-1-ene C4H8S2 120.24 CSSCC=C 10025-85-1 NITROGENTRICHLORIDE Cl3N 120.37 ClN(Cl)Cl 80-63-7 methyl2-chloro-acrylate C4H5ClO2 120.53 COC(=O)C(Cl)=C 2937-50-0 CHLORAMEISENSAEUREALLYLESTER C4H5ClO2 120.53 ClC(OCC=C)=O 600-13-5 2-CHLOR-2-BUTENSAEURE C4H5ClO2 120.53 CC=C(Cl)C(O)=O 57933-83-2 chloroformicacid,isopropenylester C4H5ClO2 120.53 CC(OC(Cl)=O)=C 14049-36-6 CHLORTRIFLUORSILAN ClF3Si 120.53 F[Si](F)(F)Cl 96-10-6 DIETHYLALUMINIUMCHLORID C4H10AlCl 120.56 CC[Al](Cl)CC 638-29-9 PENTANOYLCHLORID C5H9ClO 120.58 CCCCC(Cl)=O 108-12-3 ISOVALERIANSAEURECHLORID C5H9ClO 120.58 CC(C)CC(Cl)=O 57526-28-0 butanoylchloride,2-methyl- C5H9ClO 120.58 CCC(C)C(Cl)=O 3282-30-2 2,2-DIMETHYLPROPIONSAEURECHLORID C5H9ClO 120.58 CC(C)(C)C(Cl)=O 2855-08-5 1-CHLOR-3,3-DIMETHYLBUTAN C6H13Cl 120.62 ClCCC(C)(C)C 918-84-3 2-CHLOR-2-ETHYLBUTAN C6H13Cl 120.62 CCC(C)(Cl)CC 638-28-8 2-CHLORHEXAN C6H13Cl 120.62 CCCCC(C)Cl 544-10-5 1-CHLORHEXAN C6H13Cl 120.62 CCCCCCCl 2346-81-8 3-CHLORHEXAN C6H13Cl 120.62 CCCC(Cl)CC 1719-58-0 DIMETHYLVINYLCHLORSILAN C4H9ClSi 120.65 C[Si](C)(Cl)C=C 75-71-8 DICHLORDIFLUORMETHAN CCl2F2 120.91 FC(F)(Cl)Cl 106-95-6 3-BROM-1-PROPEN C3H5Br 120.98 BrCC=C 557-93-7 2-BROM-1-PROPEN C3H5Br 120.98 CC(Br)=C 335-01-3 PENTAFLUORMETHANAMIN CF5N 121.01 FN(F)C(F)(F)F 25346-05-8 N,N-DINITROMETHANAMIN CH3N3O4 121.05 CN(N(=O)=O)N(=O)=O 273-40-5 1h-1,2,3-triazolo[4,5-d]pyrimidine C4H3N5 121.10 c2nc1nn[nH]c1cn2 403-54-3 3-FLUORBENZONITRIL C7H4FN 121.11 Fc1cc(C#N)ccc1

Page 39 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 1194-02-1 4-FLUORBENZONITRIL C7H4FN 121.11 Fc1ccc(C#N)cc1 1122-62-9 1-(2-PYRIDINYL)ETHANON C7H7NO 121.14 CC(=O)c1ccccn1 932-90-1 BENZALDEHYDOXIM C7H7NO 121.14 ON=Cc1ccccc1 103-70-8 N-PHENYLFORMAMID C7H7NO 121.14 O=CNc1ccccc1 1122-54-9 4-PYRIDYL-METHYL-KETONE C7H7NO 121.14 CC(=O)c1ccncc1 350-03-8 1-(3-PYRIDINYL)ETHANON C7H7NO 121.14 CC(=O)c1cccnc1 6264-93-3 2-AMINO-2,4,6-CYCLOHEPTATRIEN-1-ON C7H7NO 121.14 O=C1C=CC=CC=C1N 33504-43-7 1-amino-2,4,6-cyclohepta-trien-1-one C7H7NO 121.14 O=C1C=CC=CC=C1N 55-21-0 BENZAMID C7H7NO 121.14 O=C(c1ccccc1)N 77-86-1 2-AMINO-2-(HYDROXYMETHYL)-1,3-PROPANDIOL C4H11NO3 121.14 OCC(N)(CO)CO 52-90-4 L-CYSTEIN C3H7NO2S 121.16 SCC([NH3+])C([O-])=O 611-21-2 N,2-DIMETHYLBENZOLAMIN C8H11N 121.18 CNc1ccccc1C 103-69-5 N-ETHYLBENZOLAMIN C8H11N 121.18 CCNc1ccccc1 696-44-6 benzenamine,n,3-dimethyl- C8H11N 121.18 CNc(ccc1)cc1C 623-08-5 N,4-DIMETHYLBENZOLAMIN C8H11N 121.18 CNc(cc1)ccc1C 87-62-7 2,6-DIMETHYLBENZOLAMIN C8H11N 121.18 Cc1cccc(C)c1N 578-54-1 2-ETHYLBENZOLAMIN C8H11N 121.18 CCc1ccccc1N 95-78-3 2,5-DIMETHYLBENZOLAMIN C8H11N 121.18 Cc(ccc1C)cc1N 87-59-2 2,3-DIMETHYLBENZOLAMIN C8H11N 121.18 Nc1cccc(C)c1C 95-68-1 2,4-DIMETHYLBENZOLAMIN C8H11N 121.18 Cc(ccc1N)cc1C 108-69-0 3,5-DIMETHYLBENZOLAMIN C8H11N 121.18 Nc1cc(C)cc(C)c1 587-02-0 3-ETHYLBENZOLAMIN C8H11N 121.18 CCc(ccc1)cc1N 589-16-2 4-ETHYLBENZOLAMIN C8H11N 121.18 CCc(cc1)ccc1N 95-64-7 3,4-DIMETHYLBENZOLAMIN C8H11N 121.18 Nc(ccc1C)cc1C 103434-09-9 1-norbornylisocyanide C8H11N 121.18 N#CC1(CC2)CC2CC1 1122-69-6 pyridine,2-ethyl-6-methyl- C8H11N 121.18 CCc(ccc1)nc1C 622-39-9 2-PROPYLPYRIDIN C8H11N 121.18 CCCc1ccccn1 1462-84-6 2,3,6-TRIMETHYLPYRIDIN C8H11N 121.18 Cc(ccc1C)nc1C 103-67-3 N-METHYLBENZOLMETHANAMIN C8H11N 121.18 CNCc1ccccc1 104-90-5 2-METHYL-5-ETHYLPYRIDIN C8H11N 121.18 CCc(cn1)ccc1C 89-93-0 benzenemethanamine,2-methyl- C8H11N 121.18 NCc1ccccc1C 695-98-7 2,3,5-TRIMETHYLPYRIDIN C8H11N 121.18 Cc(cnc1C)cc1C 536-88-9 4-ethyl-2-methylpyridine C8H11N 121.18 CCc(ccn1)cc1C 1122-81-2 4-PROPYLPYRIDIN C8H11N 121.18 CCCc1ccncc1 108-75-8 2,4,6-TRIMETHYLPYRIDIN C8H11N 121.18 Cc1cc(C)cc(C)n1 2233-29-6 2,3,4-trimethylpyridine C8H11N 121.18 Cc1nccc(C)c1C 696-30-0 4-(1-METHYLETHYL)PYRIDIN C8H11N 121.18 CC(C)c1ccncc1 98-84-0 ALPHA-METHYLBENZYLAMIN C8H11N 121.18 NC(C)c1ccccc1 529-21-5 3-ETHYL-4-METHYLPYRIDIN C8H11N 121.18 CCc1cnccc1C 1122-39-0 2,4,5-TRIMETHYLPYRIDIN C8H11N 121.18 Cc(ncc1C)cc1C 100-81-2 3-METHYL-1-(AMINOMETHYL)-BENZENE C8H11N 121.18 NCc(ccc1)cc1C 618-36-0 (+-)-ALPHA-METHYLBENZOLMETHANAMIN C8H11N 121.18 NC(C)c1ccccc1 104-84-7 4-METHYLBENZYLAMIN C8H11N 121.18 NCc(cc1)ccc1C 64-04-0 2-PHENYL-1-AMINO-ETHAN C8H11N 121.18 NCCc1ccccc1 121-69-7 N,N-DIMETHYLBENZOLAMIN C8H11N 121.18 CN(C)c1ccccc1 98-80-6 PHENYL-BORONICACID C6H7BO2 121.93 OB(O)c1ccccc1 274-09-9 1,2-(METHYLENDIOXY)-BENZOL C7H6O2 122.12 C(Oc1cc2)Oc1cc2 90-02-8 2-HYDROXYBENZALDEHYD C7H6O2 122.12 Oc1ccccc1C=O 65-85-0 BENZOESAEURE C7H6O2 122.12 OC(=O)c1ccccc1 553-97-9 2-METHYL-2,5-CYCLOHEXADIEN-1,4-DION C7H6O2 122.12 CC1=CC(=O)C=CC1=O 123-08-0 4-HYDROXYBENZALDEHYD C7H6O2 122.12 Oc1ccc(C=O)cc1 100-83-4 3-HYDROXYBENZALDEHYD C7H6O2 122.12 Oc1cc(C=O)ccc1 533-75-5 2-HYDROXY-2,4,6-CYCLOHEPTATRIEN-1-ON C7H6O2 122.12 OC1=CC=CC=CC1=O 623-30-3 3-(2-FURANYL)-2-PROPENAL C7H6O2 122.12 O=CC=Cc1occc1 149-32-6 ERYTHRIT C4H10O4 122.12 OCC(O)C(O)CO 696-54-8 4-pyridinealdoxime C6H6N2O 122.13 ON=Cc1ccncc1 873-69-8 2-PYRIDINCARBOXALDEHYDOXIM C6H6N2O 122.13 ON=Cc1ccccn1 22047-25-2 1-(PYRAZIN-2-YL)-1-ETHANON C6H6N2O 122.13 CC(=O)c1cnccn1 123-06-8 propanedinitrile,(ethoxymethylene)- C6H6N2O 122.13 CCOC=C(C#N)C#N 1452-77-3 2-PYRIDINCARBOXAMID C6H6N2O 122.13 O=C(c1ccccn1)N 659-49-4 4-nitrosobenzenamine C6H6N2O 122.13 Nc1ccc(N=O)cc1 1453-82-3 ISONICOTINSAEUREAMID C6H6N2O 122.13 O=C(c1ccncc1)N

Page 40 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 98-92-0 3-PYRIDINCARBOXAMID C6H6N2O 122.13 O=C(c1cccnc1)N 1120-71-4 3-HYDROXYPROPAN-1-SULFONSAEURE-GAMMA-SULTON C3H6O3S 122.14 O=S1(CCCO1)=O 405-99-2 1-ETHENYL-4-FLUORBENZOL C8H7F 122.14 Fc1ccc(C=C)cc1 98-85-1 ALPHA-METHYLBENZOLMETHANOL C8H10O 122.17 OC(C)c1ccccc1 587-03-1 3-METHYLBENZOLMETHANOL C8H10O 122.17 OCc(ccc1)cc1C 89-95-2 BENZENEMETHANOL,2-METHYL- C8H10O 122.17 OCc1ccccc1C 589-18-4 1,4-TOLYLALKOHOL C8H10O 122.17 OCc(cc1)ccc1C 104-93-8 4-METHYLANISOL C8H10O 122.17 COc(cc1)ccc1C 100-84-5 1-METHOXY-3-METHYLBENZOL C8H10O 122.17 COc(ccc1)cc1C 60-12-8 BENZOLETHANOL C8H10O 122.17 OCCc1ccccc1 5683-33-0 N,N-DIMETHYL-2-PYRIDINAMIN C7H10N2 122.17 CN(C)c1ccccn1 538-86-3 (METHOXYMETHYL)BENZOL C8H10O 122.17 COCc1ccccc1 576-26-1 2,6-DIMETHYLPHENOL C8H10O 122.17 Cc1cccc(C)c1O 103-73-1 PHENYLETHYLETHER C8H10O 122.17 CCOc1ccccc1 105-67-9 2,4-DIMETHYLPHENOL C8H10O 122.17 Cc(ccc1O)cc1C 95-65-8 3,4-DIMETHYLPHENOL C8H10O 122.17 Oc(ccc1C)cc1C 108-68-9 3,5-DIMETHYLPHENOL C8H10O 122.17 Oc1cc(C)cc(C)c1 95-87-4 2,5-DIMETHYLPHENOL C8H10O 122.17 Cc(ccc1C)cc1O 618-40-6 1-METHYL-1-PHENYLHYDRAZIN C7H10N2 122.17 CN(N)c1ccccc1 123-07-9 4-ETHYLPHENOL C8H10O 122.17 CCc(cc1)ccc1O 4210-60-0 (1,1-DIMETHYLETHYL)PROPANDINITRIL C7H10N2 122.17 CC(C)(C)C(C#N)C#N 620-17-7 3-ETHYLPHENOL C8H10O 122.17 CCc(ccc1)cc1O 526-75-0 2,3-DIMETHYLPHENOL C8H10O 122.17 Oc1cccc(C)c1C 29460-90-0 2-propan-2-ylpyrazine C7H10N2 122.17 CC(C)c1cnccn1 90-00-6 2-ETHYLPHENOL C8H10O 122.17 CCc1ccccc1O 15707-23-0 2-ETHYL-3-METHYLPYRAZIN C7H10N2 122.17 CCc1nccnc1C 623-09-6 n-methyl-1,4-benzenediamine C7H10N2 122.17 CNc(cc1)ccc1N 2687-25-4 2,3-DIAMINOTOLUOL C7H10N2 122.17 Nc1cccc(C)c1N 496-72-0 3,4-DIAMINOTOLUOL C7H10N2 122.17 Cc(ccc1N)cc1N 18138-03-9 2-propylpyrazine C7H10N2 122.17 CCCc1cnccn1 823-40-5 2,6-TOLUYLENDIAMIN C7H10N2 122.17 Nc1cccc(N)c1C 95-80-7 2,4-DIAMINOTOLUOL C7H10N2 122.17 Nc(ccc1C)cc1N 538-08-9 diallylcyanamide C7H10N2 122.17 C=CCN(CC=C)C#N 108-71-4 5-methyl-1,3-benzenediamine C7H10N2 122.17 Nc1cc(C)cc(N)c1 646-20-8 HEPTANDINITRIL C7H10N2 122.17 N#CCCCCCC#N 13360-64-0 2-ethyl-5-methylpyrazine C7H10N2 122.17 CCc(nc1)cnc1C 13925-03-6 2-ethyl-6-methylpyrazine C7H10N2 122.17 CCc(cnc1)nc1C 95-70-5 2,5-DIAMINOTOLUOL C7H10N2 122.17 Nc(ccc1N)cc1C 14667-55-1 2,3,5-TRIMETHYLPYRAZIN C7H10N2 122.17 Cc(cnc1C)nc1C 1122-58-3 N,N-DIMETHYL-4-PYRIDINAMIN C7H10N2 122.17 CN(C)c1ccncc1 2706-56-1 2-(2-AMINOETHYL)-PYRIDIN C7H10N2 122.17 NCCc1ccccn1 20173-24-4 3-(2-AMINOETHYL)-PYRIDIN C7H10N2 122.17 NCCc1cccnc1 578-58-5 1-METHOXY-2-PHENYLMETHAN C8H10O 122.17 COc1ccccc1C 111-48-8 THIODIGLYKOL C4H10O2S 122.19 OCCSCCO 597-35-3 DIETHYLSULFON C4H10O2S 122.19 CCS(CC)(=O)=O 2487-90-3 TRIMETHOXYSILAN C3H10O3Si 122.20 CO[SiH](OC)OC 17699-86-4 CYCLOHEXENE,1-METHYL-4-VINYL- C9H14 122.21 CC(CC1)=CCC1C=C 13511-13-2 CYCLOHEXENE,1-(2-PROPENYL) C9H14 122.21 C=CCC1=CCCCC1 15403-89-1 5-ETHYL-2-NORBORNEN C9H14 122.21 CCC2CC1C=CC2C1 16456-33-0 BICYCLO[4.2.1]NON-3-EN C9H14 122.21 C1CC2CC=CCC1C2 529-16-8 2,3-DIMETHYL-BICYCLO[2.2.1]HEPT-2-EN C9H14 122.21 CC(C1CC2CC1)=C2C 6671-66-5 BICYCLO[3.3.1]NON-2-EN C9H14 122.21 C(C1)CC2C=CCC1C2 7124-86-9 BICYCLO[3.2.2]NON-6-EN C9H14 122.21 C(C2)CC1C=CC2CC1 766-08-5 methylphenylsilane C7H10Si 122.24 C[SiH2]c1ccccc1 4532-64-3 2,3-BUTANDITHIOL C4H10S2 122.25 CC(S)C(C)S 16128-68-0 1,2-BUTANDITHIOL C4H10S2 122.25 CCC(S)CS 24330-52-7 1,3-BUTANDITHIOL C4H10S2 122.25 SCCC(C)S 6628-18-8 1,2-bis(methylsulfanyl)ethane C4H10S2 122.25 CSCCSC 1191-08-8 1,4-BUTANDITHIOL C4H10S2 122.25 SCCCCS 2179-60-4 2,3-DITHIAHEXAN C4H10S2 122.25 CCCSSC 110-81-6 DIETHYLDISULFID C4H10S2 122.25 CCSSCC 5781-53-3 aceticacid,chlorooxo-,methylester C3H3ClO3 122.51 COC(=O)C(Cl)=O

Page 41 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 17639-93-9 2-CHLORPROPANSAEUREMETHYLESTER C4H7ClO2 122.55 COC(C(C)Cl)=O 105-39-5 CHLORESSIGSAEUREETHYLESTER C4H7ClO2 122.55 CCOC(CCl)=O 542-58-5 2-CHLORETHANOLACETAT C4H7ClO2 122.55 ClCCOC(C)=O 627-00-9 4-CHLORBUTANSAEURE C4H7ClO2 122.55 ClCCCC(O)=O 108-23-6 CHLORKOHLENSAEURE-1-METHYLETHYLESTER C4H7ClO2 122.55 CC(C)OC(Cl)=O 109-61-5 N-PROPYLCHLORFORMIAT C4H7ClO2 122.55 CCCOC(Cl)=O 2344-80-1 silane,(chloromethyl)trimethyl- C4H11ClSi 122.67 ClC[Si](C)(C)C 506-96-7 ACETYLBROMID C2H3BrO 122.95 CC(Br)=O 821-10-3 1,4-DICHLOR-2-BUTIN C4H4Cl2 122.98 ClCC#CCCl 1653-19-6 2,3-DICHLOR-1,3-BUTADIEN C4H4Cl2 122.98 ClC(=C)C(Cl)=C 75-26-3 ISOPROPYLBROMID C3H7Br 122.99 CC(C)Br 106-94-5 1-PROPYLBROMID C3H7Br 122.99 CCCBr 630-10-4 SELENOHARNSTOFF CH4N2Se 123.02 NC(N)=[Se] 98-95-3 NITROBENZOL C6H5NO2 123.11 O=N(c1ccccc1)=O 55-22-1 4-PYRIDINCARBONSAEURE C6H5NO2 123.11 OC(=O)c1ccncc1 59-67-6 3-PYRIDINCARBONSAEURE C6H5NO2 123.11 OC(=O)c1cccnc1 98-98-6 2-PYRIDINCARBONSAEURE C6H5NO2 123.11 OC(=O)c1ccccn1 104-91-6 p-nitrosophenol C6H5NO2 123.11 Oc1ccc(N=O)cc1 98-96-4 PYRAZINECARBOXAMID C5H5N3O 123.11 O=C(c1cnccn1)N 1073-26-3 1-(1h-pyrrol-2-yl)propan-1-one C7H9NO 123.15 CCC(=O)c1[nH]ccc1 90-04-0 2-METHOXYBENZOLAMIN C7H9NO 123.15 COc1ccccc1N 5344-90-1 benzenemethanol,2-amino- C7H9NO 123.15 OCc1ccccc1N 623-10-9 n-hydroxy-4-methylbenzenamine C7H9NO 123.15 ONc(cc1)ccc1C 536-90-3 3-METHOXYBENZOLAMIN C7H9NO 123.15 COc(ccc1)cc1N 2835-96-3 4-amino-2-methylphenol C7H9NO 123.15 Nc(ccc1O)cc1C 104-94-9 4-METHOXYBENZOLAMIN C7H9NO 123.15 COc(cc1)ccc1N 95-84-1 phenol,2-amino-4-methyl- C7H9NO 123.15 Cc(ccc1O)cc1N 932-16-1 1-(1-methylpyrrol-2-yl)ethanone C7H9NO 123.15 CC(=O)c1cccn1C 2836-00-2 phenol,3-amino-4-methyl- C7H9NO 123.15 Oc(ccc1C)cc1N 1877-77-6 m-aminobenzylalcohol C7H9NO 123.15 OCc(ccc1)cc1N 1073-23-0 2,6-DIMETHYLPICOLIN-N-OXID C7H9NO 123.15 Cc1cccc(C)n1=O 103-74-2 2-(2-HYDROXYETHYL)-PYRIDIN C7H9NO 123.15 OCCc1ccccn1 461-98-3 2,6-dimethyl-4-pyrimidinamine C6H9N3 123.16 Cc1nc(C)cc(N)n1 767-15-7 2-amino-4,6-dimethylpyrimidine C6H9N3 123.16 Nc1nc(C)cc(C)n1 608-32-2 1,2,3-triaminobenzene C6H9N3 123.16 Nc1cccc(N)c1N 111-94-4 BIS-(2-CYANETHYL)-AMIN C6H9N3 123.16 N#CCCNCCC#N 615-71-4 1,2,4-benzenetriamine C6H9N3 123.16 Nc(ccc1N)cc1N 20893-30-5 2-THIOPHENACETONITRIL C6H5NS 123.18 N#CCc1sccc1 13781-53-8 3-THIOPHENACETONITRIL C6H5NS 123.18 N#CCc1cscc1 1003-90-3 2,3,4,5-tetramethyl-1h-pyrrole C8H13N 123.20 Cc1[nH]c(C)c(C)c1C 517-22-6 3-ETHYL-2,4-DIMETHYL-1H-PYRROL C8H13N 123.20 CCc1c(C)[nH]cc1C 589-33-3 1-BUTYL-1H-PYRROL C8H13N 123.20 CCCCn1cccc1 600-25-9 1-chloro-1-nitropropane C3H6ClNO2 123.54 CCC(Cl)N(=O)=O 2425-66-3 1-chloro-2-nitro-propane C3H6ClNO2 123.54 ClCC(C)N(=O)=O 503-76-4 2-chloro-1-nitropropane C3H6ClNO2 123.54 CC(Cl)CN(=O)=O 16420-13-6 carbamothioicchloride,dimethyl- C3H6ClNS 123.61 CN(C)C(Cl)=S 12185-10-3 whitephosphorus P4 123.90 p21p3p1p32 121-45-9 TRIMETHYLPHOSPHIT C3H9O3P 124.08 COP(OC)OC 765-79-6 dimethylmethanephosphonate C3H9O3P 124.08 COP(C)(OC)=O 4672-38-2 1-propylphosphonicacid C3H9O3P 124.08 CCCP(O)(O)=O 454-31-9 DIFLUORESSIGSAEUREETHYLESTER C4H6F2O2 124.09 CCOC(C(F)F)=O 2530-26-9 3-NITROPYRIDIN C5H4N2O2 124.10 O=N(c1cccnc1)=O 98-97-5 PYRAZINECARBOXYLICACID C5H4N2O2 124.10 OC(=O)c1cnccn1 455-32-3 BENZOYLFLUORID C7H5FO 124.11 FC(=O)c1ccccc1 456-48-4 benzaldehyde,3-fluoro- C7H5FO 124.11 Fc1cc(C=O)ccc1 446-52-6 2-fluor-benzaldehyd C7H5FO 124.11 Fc1ccccc1C=O 459-57-4 4-FLUORBENZALDEHYD C7H5FO 124.11 Fc1ccc(C=O)cc1 90-05-1 2-METHOXYPHENOL C7H8O2 124.14 COc1ccccc1O 90-01-7 SALICYCLALCOHOL C7H8O2 124.14 OCc1ccccc1O 6975-60-6 1-furan-2-ylpropan-2-one C7H8O2 124.14 CC(=O)Cc1occc1 623-05-2 4-HYDROXYBENZOLMETHANOL C7H8O2 124.14 OCc(cc1)ccc1O 3194-15-8 1-(2-furanyl)-1-propanone C7H8O2 124.14 CCC(=O)c1occc1

Page 42 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 620-24-6 3-HYDROXYBENZOLMETHANOL C7H8O2 124.14 OCc(ccc1)cc1O 150-76-5 4-METHOXYPHENOL C7H8O2 124.14 COc(cc1)ccc1O 150-19-6 3-METHOXYPHENOL C7H8O2 124.14 COc(ccc1)cc1O 2847-30-5 pyrazine,2-methoxy-3-methyl- C6H8N2O 124.14 COc1nccnc1C 1193-79-9 1-(5-METHYL-2-FURYL)ETHANON C7H8O2 124.14 CC(=O)c(cc1)oc1C 95-71-6 2-METHYL-1,4-BENZOLDIOL C7H8O2 124.14 Oc(ccc1O)cc1C 675-09-2 2h-pyran-2-one,4,6-dimethyl- C7H8O2 124.14 CC1=CC(C)=CC(O1)=O 504-15-4 1,3-DIHYDROXY-5-METHYLBENZOL C7H8O2 124.14 Oc1cc(C)cc(O)c1 496-73-1 1,3-DIHYDROXY-4-METHYLBENZOL C7H8O2 124.14 Oc(ccc1C)cc1O 488-17-5 3-METHYL-1,2-DIHYDROXYBENZOL C7H8O2 124.14 Oc1cccc(C)c1O 452-86-8 3,4-DIHYDROXYTOLUOL C7H8O2 124.14 Cc(ccc1O)cc1O 608-25-3 1,3-DIHYDROXY-2-METHYLBENZOL C7H8O2 124.14 Oc1cccc(O)c1C 17584-12-2 1,2,4-triazin-3-amine,5,6-dimethyl- C5H8N4 124.14 Nc(nnc1C)nc1C 1004-36-0 gamma-2,6-dimethylpyrone C7H8O2 124.14 CC1=CC(=O)C=C(C)O1 95-86-3 2,4-diaminophenol C6H8N2O 124.14 Nc(ccc1O)cc1N 1656-48-0 3,3`-HYDROXYDIPROPIONITRIL C6H8N2O 124.14 N#CCCOCCC#N 637-89-8 p-mercaptophenol C6H4OS 124.16 O=C1C=CC(=S)C=C1 62-50-0 METHANSULFONSAEUREETHYLESTER C3H8O3S 124.16 CCOS(C)(=O)=O 78-27-3 1-ETHINYLCYCLOHEXANOL C8H12O 124.18 OC1(CCCCC1)C#C 106-86-5 3-ETHENYL-7-OXABICYCLO(4.1.0)HEPTAN C8H12O 124.18 C=CC2CC1OC1CC2 932-66-1 1-(1-CYCLOHEXEN-1-YL)ETHANON C8H12O 124.18 CC(=O)C1=CCCCC1 30361-28-5 (2e,4e)-octa-2,4-dienal C8H12O 124.18 CCCC=CC=CC=O 3010-03-5 1-PIPERIDINYLACETONITRIL C7H12N2 124.18 N#CCN1CCCCC1 1123-09-7 3,5-DIMETHYL-2-CYCLOHEXENE-1-ONE C8H12O 124.18 CC1CC(=O)C=C(C)C1 4466-24-4 2-butylfuran C8H12O 124.18 CCCCc1occc1 100-53-8 BENZOLMETHANTHIOL C7H8S 124.20 SCc1ccccc1 137-06-4 1-MERCAPTO-2-METHYLBENZOL C7H8S 124.20 Cc1ccccc1S 108-40-7 3-METHYLBENZOLTHIOL C7H8S 124.20 Cc1cc(S)ccc1 106-45-6 4-METHYLBENZOLTHIOL C7H8S 124.20 Cc1ccc(S)cc1 100-68-5 (METHYLTHIO)BENZOL C7H8S 124.20 CSc1ccccc1 358-06-5 DIETHYLDIFLUORSILAN C4H10F2Si 124.20 CC[Si](F)(F)CC 3452-09-3 1-NONIN C9H16 124.22 CCCCCCCC#C 19447-29-1 2-NONIN C9H16 124.22 CCCCCCC#CC 20184-89-8 3-NONIN C9H16 124.22 CCCCCC#CCC 20184-91-2 4-NONIN C9H16 124.22 CCCCC#CCCC 4900-30-5 1,8-NONADIEN C9H16 124.22 C=CCCCCCC=C 74421-05-9 2,4-DIMETHYL-2,4-HEPTADIEN C9H16 124.22 CCC=C(C)C=C(C)C 2114-42-3 2-PROPENYLCYCLOHEXAN C9H16 124.22 C=CCC1CCCCC1 496-10-6 PERHYDRO-1H-INDAN(ISOMERENGEMISCH) C9H16 124.22 C2CC1CCCC1CC2 280-65-9 BICYCLO[3.3.1]NONAN C9H16 124.22 C(C1)CC2CC1CCC2 59-52-9 2,3-DIMERCAPTO-1-PROPANOL C3H8OS2 124.23 OCC(S)CS 289-16-7 1,2,4-TRITHIOLAN C2H4S3 124.25 0.00 97-97-2 CHLORACETALDEHYDDIMETHYLACETAL C4H9ClO2 124.57 COC(OC)CCl 693-07-2 2-CHLORETHYL-ETHYLSULFID C4H9ClS 124.63 CCSCCCl 13057-17-5 BROMMETHYL-METHYLETHER C2H5BrO 124.96 COCBr 540-51-2 2-BROMETHANOL C2H5BrO 124.96 OCCBr 1476-11-5 CIS-1,4-DICHLORBUTEN-2 C4H6Cl2 125.00 ClCC=CCCl 1871-57-4 2-(chloromethyl)-3-chloro-1-propene C4H6Cl2 125.00 ClCC(CCl)=C 764-41-0 1,4-DICHLOR-2-BUTEN C4H6Cl2 125.00 ClCC=CCCl 110-57-6 (2E)-1,4-DICHLOR-2-BUTEN C4H6Cl2 125.00 ClCC=CCCl 760-23-6 3,4-DICHLOR-1-BUTEN C4H6Cl2 125.00 ClCC(Cl)C=C 13602-13-6 1,2-dichloro-but-2-ene C4H6Cl2 125.00 ClCC(Cl)=CC 926-57-8 1,3-DICHLOR-2-BUTEN C4H6Cl2 125.00 ClCC=C(C)Cl 10075-38-4 1,3-DICHLOR-2-BUTEN(Z) C4H6Cl2 125.00 ClCC=C(C)Cl 128-53-0 1h-pyrrole-2,5-dione,1-ethyl- C6H7NO2 125.13 CCN1C(=O)C=CC1=O 1004-38-2 2,4,6-pyrimidinetriamine C4H7N5 125.13 Nc1nc(N)cc(N)n1 1122-47-0 4-AMINO-1-METHYL-2(1H)-PYRIMIDINON C5H7N3O 125.13 CN1C=CC(N)=NC1=O 554-01-8 5-methylcytosine C5H7N3O 125.13 CC1=CNC(=O)N=C1N 452-71-1 benzenamine,4-fluoro-2-methyl- C7H8FN 125.14 Fc(ccc1N)cc1C 107-35-7 2-AMINOETHANESULFONICACID C2H7NO3S 125.15 [NH3+]CCS([O-])(=O)=O 931-97-5 1-HYDROXYCYCLOHEXANCARBONITRIL C7H11NO 125.17 OC1(CCCCC1)C#N 30408-61-8 4-ethyl-2,5-dimethyl-1,3-oxazole C7H11NO 125.17 CCc1nc(C)oc1C

Page 43 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 53833-30-0 2-ethyl-4,5-dimethyl-1,3-oxazole C7H11NO 125.17 CCc(nc1C)oc1C 4688-60-2 n,n-dimethylamino-2,4-pentadiene-5-al C7H11NO 125.17 CN(C)C=CC=CC=O 3173-53-3 CYCLOHEXANE,ISOCYANATO- C7H11NO 125.17 O=C=NC1CCCCC1 137-07-5 2-MERCAPTOANILIN C6H7NS 125.19 Nc1ccccc1S 1759-28-0 5-ethenyl-4-methyl-1,3-thiazole C6H7NS 125.19 Cc1ncsc1C=C 1193-02-8 4-aminobenzenethiol C6H7NS 125.19 Nc1ccc(S)cc1 22948-02-3 3-aminobenzenethiol C6H7NS 125.19 Nc1cc(S)ccc1 2044-73-7 pyridin-2-ylmethanethiol C6H7NS 125.19 SCc1ccccn1 22581-72-2 pyridine,4-(methylthio)- C6H7NS 125.19 CSc1ccncc1 6887-59-8 4(1h)-pyridinethione,1-methyl- C6H7NS 125.19 CN1C=CC(=S)C=C1 124-12-9 OCTANSAEURENITRIL C8H15N 125.21 CCCCCCCC#N 529-17-9 tropane C8H15N 125.21 CN1C2CCC1CCC2 283-24-9 3-AZABICYCLO-(3,2,2)-NONAN C8H15N 125.21 N(C2)CC1CCC2CC1 813-78-5 phosphoricaciddimethylester C2H7O4P 126.05 COP(O)(OC)=O 406-90-6 2,2,2-TRIFLUORETHYL-VINYLETHER C4H5F3O 126.08 FC(F)(F)COC=C 766-39-2 3,4-DIMETHYL-2,5-FURANDION C6H6O3 126.11 CC1=C(C)C(OC1=O)=O 611-13-2 FURAN-2-CARBONSAEUREMETHYLESTER C6H6O3 126.11 COC(=O)c1occc1 1917-15-3 5-methyl-2-furancarboxylicacid C6H6O3 126.11 OC(=O)c(cc1)oc1C 3420-59-5 isomaltol C6H6O3 126.11 CC(=O)c1occc1O 118-71-8 3-HYDROXY-2-METHYL-4H-PYRAN-4-ON C6H6O3 126.11 CC(OC=CC1=O)=C1O 533-73-3 1,2,4-BENZOLTRIOL C6H6O3 126.11 Oc(ccc1O)cc1O 87-66-1 1,2,3-BENZOLTRIOL C6H6O3 126.11 Oc1cccc(O)c1O 108-73-6 1,3,5-BENZOLTRIOL C6H6O3 126.11 Oc1cc(O)cc(O)c1 67-47-0 5-(HYDROXYMETHYL)-2-FURANCARBOXALDEHYD C6H6O3 126.11 OCc1oc(C=O)cc1 615-77-0 1-METHYL-2,4(1H,3H)-PYRIMIDINDION C5H6N2O2 126.11 Cn1ccc(=O)[nH]c1=O 608-34-4 3-METHYL-2,4(1H,3H)-PYRIMIDINDION C5H6N2O2 126.11 Cn1c([nH]ccc1=O)=O 626-48-2 6-METHYL-2,4(1H,3H)-PYRIMIDINDION C5H6N2O2 126.11 Cc1[nH]c(=O)[nH]c(=O)c1 65-71-4 5-METHYL-2,4(1H,3H)-PYRIMIDINDION C5H6N2O2 126.11 Cc1c[nH]c(=O)[nH]c1=O 108-78-1 MELAMIN C3H6N6 126.12 Nc1nc(N)nc(N)n1 56-06-4 2,6-DIAMINO-4(1H)-PYRIMIDINON C4H6N4O 126.12 Nc1nc(N)cc(O)n1 321-28-8 1-FLUOR-2-METHOXYBENZOL C7H7FO 126.13 COc1ccccc1F 459-60-9 1-FLUOR-4-METHOXYBENZOL C7H7FO 126.13 COc(cc1)ccc1F 77-78-1 SCHWEFELSAEUREDIMETHYLESTER C2H6O4S 126.13 COS(OC)(=O)=O 456-47-3 benzenemethanol,3-fluoro- C7H7FO 126.13 OCc(ccc1)cc1F 456-49-5 1-FLUOR-3-METHOXYBENZOL C7H7FO 126.13 COc(ccc1)cc1F 446-51-5 benzenemethanol,2-fluoro- C7H7FO 126.13 OCc1ccccc1F 459-56-3 benzenemethanol,4-fluoro- C7H7FO 126.13 OCc(cc1)ccc1F 540-82-9 SULFURICACIDMONOETHYLESTER C2H6O4S 126.13 CCOS(O)(=O)=O 636-82-8 1-cyclohexene-1-carboxylicacid C7H10O2 126.15 OC(=O)C1=CCCCC1 96-05-9 METHACRYLSAEUREALLYLESTER C7H10O2 126.15 C=CCOC(=O)C(C)=C 4771-80-6 3-cyclohexene-1-carboxylicacid C7H10O2 126.15 OC(C1CC=CCC1)=O 6270-56-0 2-(ethoxymethyl)furan C7H10O2 126.15 CCOCc1occc1 21835-01-8 3-ethyl-2-hydroxycyclopent-2-en-1-one C7H10O2 126.15 CCC(CCC1=O)=C1O 1515-80-6 2,4-hexadienoicacidmethylester C7H10O2 126.15 COC(=O)C=CC=CC 13494-07-0 3,5-dimethylcyclopentane-1,2-dione C7H10O2 126.15 CC1CC(C)C(=O)C1=O 13494-06-9 3,4-dimethylcyclopentane-1,2-dione C7H10O2 126.15 CC1CC(=O)C(C1C)=O 3008-39-7 1,2-cycloheptanedione C7H10O2 126.15 O=C1CCCCCC1=O 3008-43-3 3-methylcyclohexane-1,2-dione C7H10O2 126.15 CC1CCCC(=O)C1=O 4350-84-9 2-oxabicyclo[2.2.2]octan-3-one C7H10O2 126.15 O=C2OC1CCC2CC1 1121-24-0 o-mercaptophenol C6H6OS 126.18 Oc1ccccc1S 1468-83-3 1-(3-THIENYL)ETHANON C6H6OS 126.18 CC(=O)c1cscc1 88-15-3 1-(2-THIENYL)ETHANON C6H6OS 126.18 CC(=O)c1sccc1 13679-70-4 5-methylthiophene-2-carbaldehyde C6H6OS 126.18 Cc1sc(C=O)cc1 21948-70-9 2-methylsulfanylpyrazine C5H6N2S 126.18 CSc1cnccn1 59021-02-2 pyrazin-2-ylmethanethiol C5H6N2S 126.18 SCc1cnccn1 18409-20-6 (2e,4e)-octa-2,4-dien-1-ol C8H14O 126.20 CCCC=CC=CCO 41547-22-2 (z)-oct-5-enal C8H14O 126.20 CCC=CCCCC=O 25201-40-5 4-METHYL-1,6-HEPTADIEN-4-OL C8H14O 126.20 OC(C)(CC=C)CC=C 283-27-2 3-OXABICYCLO[3.2.2]NONAN C8H14O 126.20 O(C2)CC1CCC2CC1 286-62-4 9-OXABICYCLO(6.1.0)NONAN C8H14O 126.20 C2CCC1OC1CCC2 4312-99-6 oct-1-en-3-one C8H14O 126.20 CCCCCC(=O)C=C 693-13-0 n,n'-methanetetraylbis-2-propanamine C7H14N2 126.20 CC(C)N=C=NC(C)C

Page 44 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 645-62-5 2-ETHYL-2-HEXENAL C8H14O 126.20 CCCC=C(CC)C=O 1447-26-3 5-methyl-4-hepten-3-one C8H14O 126.20 CCC(C)=CC(CC)=O 110-93-0 2-METHYL-2-HEPTEN-6-ON C8H14O 126.20 CC(CCC=C(C)C)=O 1193-47-1 2,2-dimethylcyclohexanone C8H14O 126.20 CC1(C)CCCCC1=O 823-76-7 ACETYLCYCLOHEXAN C8H14O 126.20 CC(C1CCCCC1)=O 2816-57-1 2,6-DIMETHYLCYCLOHEXANON C8H14O 126.20 CC1CCCC(C)C1=O 932-56-9 2-methylcycloheptanone C8H14O 126.20 CC1CCCCCC1=O 5441-51-0 cyclohexanone,4-ethyl- C8H14O 126.20 CCC1CCC(CC1)=O 2979-19-3 3,3-dimethylcyclohexanone C8H14O 126.20 CC1(C)CC(CCC1)=O 502-49-8 CYCLOOCTANON C8H14O 126.20 O=C1CCCCCCC1 2721-31-5 4,5-DIHYDRO-3,3,5,5-TETRAMETHYL-3H-PYRAZOL C7H14N2 126.20 CC1(C)N=NC(C)(C)C1 1551-27-5 2-PROPYLTHIOPHEN C7H10S 126.22 CCCc1sccc1 4095-22-1 2-(1-METHYLETHYL)THIOPHEN C7H10S 126.22 CC(C)c1sccc1 1795-04-6 2,3,4-TRIMETHYLTHIOPHEN C7H10S 126.22 Cc1csc(C)c1C 1795-05-7 THIOPHENE,2,3,5-TRIMETHYL- C7H10S 126.22 Cc(cc1C)sc1C 4588-18-5 2-METHYL-1-OCTEN C9H18 126.24 CCCCCCC(C)=C 13151-06-9 7-METHYL-1-OCTEN C9H18 126.24 CC(C)CCCCC=C 6434-77-1 (2Z)-2-NONEN C9H18 126.24 CCCCCCC=CC 124-11-8 1-NONEN C9H18 126.24 CCCCCCCC=C 6434-78-2 (2E)-2-NONEN C9H18 126.24 CCCCCCC=CC 20063-92-7 (3E)-3-NONEN C9H18 126.24 CCCCCC=CCC 50876-33-0 1,1,3,3-TETRAMETHYLCYCLOPENTAN C9H18 126.24 CC1(C)CC(C)(C)CC1 7094-26-0 1,1,2-TRIMETHYLCYCLOHEXAN C9H18 126.24 CC1CCCCC1(C)C 3073-66-3 1,1,3-TRIMETHYLCYCLOHEXAN C9H18 126.24 CC(CCC1)CC1(C)C 1795-26-2 (1ALPHA,3ALPHA,5BETA)-1,3,5-TRIMETHYLCYCLOHEXAN C9H18 126.24 CC1CC(C)CC(C)C1 7667-60-9 TRANS,CIS-1,2,4-TRIMETHYLCYCLOHEXAN C9H18 126.24 CC(CCC1C)CC1C 3788-32-7 (2-METHYLPROPYL)CYCLOPENTAN C9H18 126.24 CC(C)CC1CCCC1 4926-90-3 1-ETHYL-1-METHYLCYCLOHEXAN C9H18 126.24 CCC1(C)CCCCC1 19489-10-2 CIS-1-ETHYL-3-METHYLCYCLOHEXAN C9H18 126.24 CCC(CCC1)CC1C 1678-97-3 cyclohexane,1,2,3-trimethyl- C9H18 126.24 CC1CCCC(C)C1C 1678-81-5 R-1,T-2,C-3-TRIMETHYLCYCLOHEXAN C9H18 126.24 CC1CCCC(C)C1C 7667-55-2 1,2-CIS-1,3-TRANS-1,2,3-TRIMETHYLCYCLOHEXAN C9H18 126.24 CC1CCCC(C)C1C 4926-78-7 CIS-1-ETHYL-4-METHYLCYCLOHEXAN C9H18 126.24 CCC(CC1)CCC1C 6236-88-0 TRANS-1-ETHYL-4-METHYLCYCLOHEXAN C9H18 126.24 CCC(CC1)CCC1C 2040-95-1 BUTYLCYCLOPENTAN C9H18 126.24 CCCCC1CCCC1 4923-77-7 CIS-1-ETHYL-2-METHYLCYCLOHEXAN C9H18 126.24 CCC1CCCCC1C 696-29-7 (1-METHYLETHYL)CYCLOHEXAN C9H18 126.24 CC(C)C1CCCCC1 1678-92-8 PROPYLCYCLOHEXAN C9H18 126.24 CCCC1CCCCC1 3658-80-8 DIMETHYLTRISULFID C2H6S3 126.27 CSSSC 100-44-7 (CHLORMETHYL)BENZOL C7H7Cl 126.58 ClCc1ccccc1 106-43-4 1-CHLOR-4-METHYLBENZOL C7H7Cl 126.58 Cc1ccc(Cl)cc1 108-41-8 1-CHLOR-3-METHYLBENZOL C7H7Cl 126.58 Cc1cc(Cl)ccc1 95-49-8 2-CHLORTOLUOL C7H7Cl 126.58 Cc1ccccc1Cl 79-37-8 ETHANDIOYLDICHLORID C2Cl2O2 126.93 ClC(=O)C(Cl)=O 563-43-9 DICHLORETHYLALUMINIUM C2H5AlCl2 126.95 CC[Al](Cl)Cl 762-49-2 1-BROM-2-FLUORETHAN C2H4BrF 126.96 FCCBr 513-88-2 1,1-DICHLOR-2-PROPANON C3H4Cl2O 126.97 ClC(Cl)C(C)=O 625-36-5 3-CHLORPROPIONSAEURECHLORID C3H4Cl2O 126.97 ClCCC(Cl)=O 534-07-6 1,3-DICHLORACETON C3H4Cl2O 126.97 ClCC(CCl)=O 110-56-5 1,4-DICHLORBUTAN C4H8Cl2 127.01 ClCCCCCl 1190-22-3 1,3-DICHLORBUTAN C4H8Cl2 127.01 ClCCC(C)Cl 2211-67-8 2,3-dichlorobutane C4H8Cl2 127.01 CC(Cl)C(C)Cl 616-19-3 1,3-DICHLOR-2-METHYLPROPAN C4H8Cl2 127.01 ClCC(C)CCl 594-37-6 1,2-DICHLOR-2-METHYLPROPAN C4H8Cl2 127.01 ClCC(C)(C)Cl 616-21-7 1,2-DICHLORBUTAN C4H8Cl2 127.01 CCC(Cl)CCl 541-33-3 1,1-DICHLORBUTAN C4H8Cl2 127.01 CCCC(Cl)Cl 598-76-5 1,1-DICHLOR-2-METHYL-PROPAN C4H8Cl2 127.01 CC(C)C(Cl)Cl 4279-22-5 2,2-DICHLORBUTAN C4H8Cl2 127.01 CCC(C)(Cl)Cl 7782-78-7 NITROSYLHYDROGENSULFAT HNO5S 127.08 0.00 88054-22-2 2-METHYL-5-NITRO-1H-IMIDAZOL C4H5N3O2 127.10 Cc1[nH]c(cn1)N(=O)=O 932-53-6 6-azathymine C4H5N3O2 127.10 Cc1n[nH]c(=O)[nH]c1=O 932-52-5 5-AMINO-2,4(1H,3H)-PYRIMIDINDION C4H5N3O2 127.10 Nc1c[nH]c(=O)[nH]c1=O

Page 45 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 2314-78-5 1-ETHYL-2,5-PYRROLIDINDION C6H9NO2 127.14 CCN1C(CCC1=O)=O 24295-03-2 1-(1,3-thiazol-2-yl)ethanone C5H5NOS 127.17 CC(=O)c1sccn1 5813-89-8 2-THIOPHENCARBOXAMID C5H5NOS 127.17 O=C(N)c1sccc1 333-49-3 4-amino-2(1h)-pyrimidinethione C4H5N3S 127.17 NC1=NC(=S)NC=C1 1619-34-7 1-azabicyclo2.2.2octan-3-ol C7H13NO 127.18 OC2CN1CCC2CC1 766-93-8 n-cyclohexylformamide C7H13NO 127.18 O=CNC1CCCCC1 618-42-8 1-ACETYLPIPERIDIN C7H13NO 127.18 CC(=O)N1CCCCC1 673-66-5 OENANTHSAEURELACTAM C7H13NO 127.18 O=C1NCCCCCC1 15679-12-6 2-ethyl-4-methyl-1,3-thiazole C6H9NS 127.21 CCc(sc1)nc1C 13623-11-5 2,4,5-trimethyl-1,3-thiazole C6H9NS 127.21 Cc(nc1C)sc1C 18060-79-2 5-isothiocyanatopent-1-ene C6H9NS 127.21 C=CCCCN=C=S 98-94-2 N,N-DIMETHYLAMINOCYCLOHEXAN C8H17N 127.23 CN(C)C1CCCCC1 767-10-2 n-butylpyrrolidine C8H17N 127.23 CCCCN1CCCC1 458-88-8 2-propylpiperidine C8H17N 127.23 CCCC1CCCCN1 5452-37-9 CYCLOOCTANAMIN C8H17N 127.23 NC1CCCCCCC1 18368-63-3 6-chloro-2-picoline C6H6ClN 127.57 Cc1nc(Cl)ccc1 3678-62-4 2-chloro-4-methylpyridine C6H6ClN 127.57 Cc1cc(Cl)ncc1 95-51-2 2-CHLORBENZOLAMIN C6H6ClN 127.57 Nc1ccccc1Cl 106-47-8 4-CHLORBENZOLAMIN C6H6ClN 127.57 Nc1ccc(Cl)cc1 108-42-9 3-CHLORBENZOLAMIN C6H6ClN 127.57 Nc1cc(Cl)ccc1 10034-85-2 IODWASSERSTOFF HI 127.91 I 353-82-2 DICHLORFLUORACETONITRIL C2Cl2FN 127.93 FC(Cl)(Cl)C#N 683-72-7 2,2-DICHLORACETAMID C2H3Cl2NO 127.96 ClC(Cl)C(=O)N 431-47-0 TRIFLUORESSIGSAEUREMETHYLESTER C3H3F3O2 128.05 COC(C(F)(F)F)=O 461-18-7 4,4,4-trifluoro-1-butanol C4H7F3O 128.09 OCCCC(F)(F)F 507-52-8 1,1,1-TRIFLUOR-2-METHYL-2-PROPANOL C4H7F3O 128.09 FC(F)(F)C(O)(C)C 67-52-7 2,4,6(1H,3H,5H)-PYRIMIDINTRION C4H4N2O3 128.09 O=C1NC(=O)NC(C1)=O 670-54-2 ETHENTETRACARBONITRIL C6N4 128.09 N#CC(C#N)=C(C#N)C#N 28664-35-9 3-hydroxy-4,5-dimethyl-5h-furan-2-one C6H8O3 128.13 CC1OC(=O)C(O)=C1C 106-90-1 glycidylacrylate C6H8O3 128.13 C=CC(OCC1OC1)=O 3658-77-3 4-hydroxy-2,5-dimethylfuran-3-one C6H8O3 128.13 CC1OC(C)=C(O)C1=O 517-23-7 2-ACETYLBUTYROLACTON C6H8O3 128.13 CC(C1CCOC1=O)=O 626-17-5 ISOPHTHALSAEUREDINITRIL C8H4N2 128.13 N#Cc1cc(C#N)ccc1 623-26-7 TEREPHTHALSAEUREDINITRIL C8H4N2 128.13 N#Cc1ccc(C#N)cc1 91-15-6 PHTHALSAEUREDINITRIL C8H4N2 128.13 N#Cc1ccccc1C#N 77-71-4 5,5-DIMETHYL-2,4-IMIDAZOLIDINDION C5H8N2O2 128.13 CC1(C)NC(=O)NC1=O 3088-42-4 glycine,n-(2-cyanoethyl)- C5H8N2O2 128.13 OC(CNCCC#N)=O 88-13-1 3-THENOICACID C5H4O2S 128.15 OC(=O)c1cscc1 527-72-0 2-THIOPHENCARBONSAEURE C5H4O2S 128.15 OC(=O)c1sccc1 141-90-2 2-thiouracil C4H4N2OS 128.15 O=c1[nH]c([nH]cc1)=S 591-28-6 4-thiouracil C4H4N2OS 128.15 O=c1[nH]c(cc[nH]1)=S 13706-86-0 5-methylhexane-2,3-dione C7H12O2 128.17 CC(C)CC(=O)C(C)=O 98-89-5 CYCLOHEXANCARBONSAEURE C7H12O2 128.17 OC(C1CCCCC1)=O 1123-00-8 CYCLOPENTANESSIGSAEURE C7H12O2 128.17 OC(CC1CCCC1)=O 3377-92-2 2,2-DIMETHYLPROPANSAEUREETHENYLESTER C7H12O2 128.17 CC(C)(C)C(OC=C)=O 18999-28-5 (e)-hept-2-enoic acid C7H12O2 128.17 CCCCC=CC(O)=O 96-04-8 heptane-2,3-dione C7H12O2 128.17 CCCCC(=O)C(C)=O 638-10-8 3-METHYL-2-BUTENSAEUREETHYLESTER C7H12O2 128.17 CCOC(=O)C=C(C)C 2998-08-5 2-PROPENSAEURE-1-METHYLPROPYLESTER C7H12O2 128.17 CCC(C)OC(=O)C=C 141-32-2 2-PROPENSAEUREBUTYLESTER C7H12O2 128.17 CCCCOC(=O)C=C 106-63-8 2-PROPENSAEURE-2-METHYLPROPYLESTER C7H12O2 128.17 CC(C)COC(=O)C=C 4351-54-6 AMEISENSAEURECYCLOHEXYLESTER C7H12O2 128.17 O=COC1CCCCC1 4655-34-9 2-METHYL-2-PROPENSAEURE-1-METHYLETHYLESTER C7H12O2 128.17 CC(C)OC(=O)C(C)=C 2051-78-7 BUTANSAEURE-2-PROPENYLESTER C7H12O2 128.17 CCCC(OCC=C)=O 2210-28-8 2-METHYL-2-PROPENSAEUREPROPYLESTER C7H12O2 128.17 CCCOC(=O)C(C)=C 1119-60-4 hept-6-enoicacid C7H12O2 128.17 OC(CCCCC=C)=O 10160-87-9 3,3-diethoxy-propyne C7H12O2 128.17 CCOC(OCC)C#C 5837-78-5 2-butenoicacid,2-methyl-,ethylester,(e)- C7H12O2 128.17 CCOC(=O)C(C)=CC 1576-85-8 4-PENTEN-1-OLACETAT C7H12O2 128.17 CC(OCCCC=C)=O 7424-54-6 3,5-heptadione C7H12O2 128.17 CCC(CC(CC)=O)=O 1540-34-7 2,4-pentanedione,3-ethyl- C7H12O2 128.17 CCC(C(C)=O)C(C)=O 105-21-5 DIHYDRO-5-PROPYL-2(3H)-FURANON C7H12O2 128.17 CCCC1OC(CC1)=O

Page 46 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 275-51-4 AZULEN C10H8 128.17 c2ccc1cccc1cc2 91-20-3 NAPHTHALIN C10H8 128.17 c(ccc1cc2)cc1cc2 1438-91-1 2-(methylsulfanylmethyl)furan C6H8OS 128.19 CSCc1occc1 55764-23-3 2,5-dimethylfuran-3-thiol C6H8OS 128.19 Cc(oc1C)cc1S 13678-59-6 2-methyl-5-methylsulfanylfuran C6H8OS 128.19 CSc(cc1)oc1C 64275-73-6 (z)-oct-5-en-1-ol C8H16O 128.21 OCCCCC=CCC 18409-17-1 (2E)-2-OCTEN-1-OL C8H16O 128.21 CCCCCC=CCO 57648-55-2 oct-3-en-2-ol C8H16O 128.21 CCCCC=CC(O)C 4630-06-2 6-methyl-5-hepten-2-ol C8H16O 128.21 CC(C)CC=CC(O)C 20125-81-9 (e)-oct-2-en-4-ol C8H16O 128.21 CCCCC(O)C=CC 16630-91-4 2-METHYLHEPTANAL C8H16O 128.21 CCCCCC(C)C=O 123-05-7 2-ETHYLHEXANAL C8H16O 128.21 CCCCC(CC)C=O 767-12-4 3,3-dimethylcyclohexanol C8H16O 128.21 OC(CCC1)CC1(C)C 41239-48-9 2,5-diethyloxolane C8H16O 128.21 CCC1OC(CC)CC1 3329-48-4 3,5-dimethyl-1-hexen-3-ol C8H16O 128.21 CC(C)CC(O)(C)C=C 124-13-0 1-OCTANAL C8H16O 128.21 CCCCCCCC=O 4442-79-9 CYCLOHEXANETHANOL C8H16O 128.21 OCCC1CCCCC1 3391-86-4 1-OCTEN-3-OL C8H16O 128.21 CCCCCC(O)C=C 1569-60-4 2-METHYL-2-HEPTEN-6-OL C8H16O 128.21 OC(C)CCC=C(C)C 1888-57-9 2,5-DIMETHYL-3-HEXANON C8H16O 128.21 CC(C)CC(C(C)C)=O 696-71-9 CYCLOOCTANOL C8H16O 128.21 OC1CCCCCCC1 626-33-5 2-methyl-4-heptanone C8H16O 128.21 CCCC(CC(C)C)=O 541-85-5 5-METHYL-3-HEPTANON C8H16O 128.21 CCC(C)CC(CC)=O 13019-20-0 2-METHYL-3-HEPTANON C8H16O 128.21 CCCCC(C(C)C)=O 589-63-9 4-OCTANON C8H16O 128.21 CCCCC(CCC)=O 624-42-0 3-HEPTANONE,6-METHYL- C8H16O 128.21 CC(C)CCC(CC)=O 106-68-3 3-OCTANON C8H16O 128.21 CCCCCC(CC)=O 1193-81-3 ALPHA-METHYLCYCLOHEXANMETHANOL C8H16O 128.21 OC(C)C1CCCCC1 2371-19-9 3-methyl-2-heptanone C8H16O 128.21 CCCCC(C)C(C)=O 1193-46-0 2,2-dimethylcyclohexanol C8H16O 128.21 OC1CCCCC1(C)C 111-13-7 2-OCTANON C8H16O 128.21 CCCCCCC(C)=O 928-68-7 6-METHYL-2-HEPTANON C8H16O 128.21 CC(C)CCCC(C)=O 1940-18-7 1-ETHYLCYCLOHEXANOL C8H16O 128.21 CCC1(O)CCCCC1 3358-28-9 tetrahydro-2,2,4,4-tetramethylfuran C8H16O 128.21 CC1(C)CC(C)(C)CO1 15045-43-9 TETRAHYDRO-2,2,5,5-TETRAMETHYLFURAN C8H16O 128.21 CC1(C)OC(C)(C)CC1 5337-72-4 2,6-DIMETHYLCYCLOHEXANOL C8H16O 128.21 CC1CCCC(C)C1O 34885-03-5 4-METHYL-CYCLOHEXANEMETHANOL C8H16O 128.21 OCC(CC1)CCC1C 120-85-4 1,2,4-trimethylpiperazine C7H16N2 128.22 CN(CCN1C)CC1C 16747-38-9 2,3,3,4-TETRAMETHYLPENTAN C9H20 128.26 CC(C)C(C)(C)C(C)C 1186-53-4 2,2,3,4-TETRAMETHYLPENTAN C9H20 128.26 CC(C)C(C)C(C)(C)C 7154-79-2 2,2,3,3-TETRAMETHYLPENTAN C9H20 128.26 CCC(C)(C)C(C)(C)C 1070-87-7 2,2,4,4-TETRAMETHYLPENTAN C9H20 128.26 CC(C)(C)CC(C)(C)C 3074-77-9 3-ETHYL-4-METHYLHEXAN C9H20 128.26 CCC(C)C(CC)CC 16747-32-3 3-ETHYL-2,2-DIMETHYLPENTAN C9H20 128.26 CCC(CC)C(C)(C)C 16747-25-4 2,2,3-TRIMETHYLHEXAN C9H20 128.26 CCCC(C)C(C)(C)C 1067-20-5 3,3-DIETHYLPENTAN C9H20 128.26 CCC(CC)(CC)CC 921-47-1 2,3,4-TRIMETHYLHEXAN C9H20 128.26 CCC(C)C(C)C(C)C 3522-94-9 2,2,5-TRIMETHYLHEXAN C9H20 128.26 CC(C)CCC(C)(C)C 926-82-9 3,5-DIMETHYLHEPTAN C9H20 128.26 CCC(C)CC(C)CC 3074-76-8 3-ETHYL-3-METHYLHEXAN C9H20 128.26 CCCC(C)(CC)CC 16747-26-5 2,2,4-TRIMETHYLHEXAN C9H20 128.26 CCC(C)CC(C)(C)C 16747-30-1 2,4,4-TRIMETHYLHEXAN C9H20 128.26 CCC(C)(C)CC(C)C 16789-46-1 3-ETHYL-2-METHYLHEXAN C9H20 128.26 CCCC(CC)C(C)C 1068-87-7 3-ETHYL-2,4-DIMETHYLPENTAN C9H20 128.26 CCC(C(C)C)C(C)C 3074-75-7 4-ETHYL-2-METHYLHEXAN C9H20 128.26 CCC(CC)CC(C)C 1069-53-0 2,3,5-TRIMETHYLHEXAN C9H20 128.26 CC(C)CC(C)C(C)C 1071-26-7 2,2-DIMETHYLHEPTAN C9H20 128.26 CCCCCC(C)(C)C 1068-19-5 4,4-DIMETHYLHEPTAN C9H20 128.26 CCCC(C)(C)CCC 2213-23-2 2,4-DIMETHYLHEPTAN C9H20 128.26 CCCC(C)CC(C)C 1072-05-5 2,6-DIMETHYLHEPTAN C9H20 128.26 CC(C)CCCC(C)C 2216-30-0 2,5-DIMETHYLHEPTAN C9H20 128.26 CCC(C)CCC(C)C 2216-34-4 4-METHYLOCTAN C9H20 128.26 CCCCC(C)CCC

Page 47 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 922-28-1 3,4-DIMETHYLHEPTAN C9H20 128.26 CCCC(C)C(C)CC 2216-33-3 3-METHYLOCTAN C9H20 128.26 CCCCCC(C)CC 3221-61-2 2-METHYLOCTAN C9H20 128.26 CCCCCCC(C)C 15869-80-4 3-ETHYLHEPTAN C9H20 128.26 CCCCC(CC)CC 111-84-2 NONAN C9H20 128.26 CCCCCCCCC 95-57-8 2-CHLORPHENOL C6H5ClO 128.56 Oc1ccccc1Cl 1072-98-6 5-CHLOR-2-PYRIDINAMIN C5H5ClN2 128.56 Nc1ccc(Cl)cn1 106-48-9 4-CHLORPHENOL C6H5ClO 128.56 Oc1ccc(Cl)cc1 108-43-0 3-CHLORPHENOL C6H5ClO 128.56 Oc1cc(Cl)ccc1 594-44-5 ETHANSULFONYLCHLORID C2H5ClO2S 128.58 CCS(Cl)(=O)=O 22128-62-7 chloroformicacid,chloromethylester C2H2Cl2O2 128.94 ClCOC(Cl)=O 79-43-6 DICHLORESSIGSAEURE C2H2Cl2O2 128.94 ClC(Cl)C(O)=O 430-95-5 1,1-dichloro-2-fluoro-1-propene C3H3Cl2F 128.96 FC(C)=C(Cl)Cl 7783-00-8 SELENIGESAEURE H2O3Se 128.98 O[Se](O)=O 96-23-1 1,2-DICHLOR-2-PROPANOL C3H6Cl2O 128.99 ClCC(O)CCl 616-23-9 2,3-DICHLOR-1-PROPANOL C3H6Cl2O 128.99 OCC(Cl)CCl 75-78-5 DICHLORDIMETHYLSILAN C2H6Cl2Si 129.06 C[Si](C)(Cl)Cl 108-80-5 1,3,5-TRIAZIN-2,4,6(1H,3H,5H)-TRION C3H3N3O3 129.07 Oc1nc(O)nc(O)n1 2022-85-7 flucytosine C4H4FN3O 129.09 FC1=CNC(=O)N=C1N 367-25-9 2,4-DIFLUORBENZOLAMIN C6H5F2N 129.11 Fc(ccc1N)cc1F 695-53-4 2,4-oxazolidinedione,5,5-dimethyl- C5H7NO3 129.11 CC1(C)OC(=O)NC1=O 149-87-1 5-OXO-DL-PROLIN C5H7NO3 129.11 OC(=O)C1NC(CC1)=O 1633-44-9 3,4-pyridinedicarbonitrile C7H3N3 129.12 N#Cc1cnccc1C#N 609-40-5 2-NITROTHIOPHEN C4H3NO2S 129.14 O=N(=O)c1sccc1 822-84-4 3-nitrothiophene C4H3NO2S 129.14 O=N(=O)c1cscc1 1122-60-7 NITROCYCLOHEXAN C6H11NO2 129.16 O=N(C1CCCCC1)=O 498-95-3 nipecoticacid C6H11NO2 129.16 OC(C1CCCNC1)=O 498-94-2 isonipecoticacid C6H11NO2 129.16 OC(C1CCNCC1)=O 535-75-1 2-piperidinecarboxylicacid C6H11NO2 129.16 OC(C1CCCCN1)=O 1885-38-7 3-phenyl-2-propenenitrile C9H7N 129.16 N#CC=Cc1ccccc1 91-22-5 CHINOLIN C9H7N 129.16 c2nc1ccccc1cc2 119-65-3 ISOCHINOLIN C9H7N 129.16 n2cc1ccccc1cc2 1696-20-4 N-ACETYLMORPHOLIN C6H11NO2 129.16 CC(=O)N1CCOCC1 3445-11-2 N-HYDROXYETHYLPYRROLIDON C6H11NO2 129.16 OCCN1CCCC1=O 52-52-8 1-AMINOCYCLOPENTANCARBONSAEURE C6H11NO2 129.16 [NH3+]C1(CCCC1)C([O-])=O 15679-19-3 2-ethoxy-1,3-thiazole C5H7NOS 129.18 CCOc1sccn1 29926-41-8 1-(4,5-dihydro-1,3-thiazol-2-yl)ethanone C5H7NOS 129.18 CC(=O)C1=NCCS1 38205-64-0 5-methoxy-2-methyl-1,3-thiazole C5H7NOS 129.18 COc(cn1)sc1C 500-12-9 goitrin C5H7NOS 129.18 C=CC1OC(=S)NC1 624-44-2 5-methyl-2-hexanoneoxime C7H15NO 129.20 CC(C)CCC(C)=NO 629-31-2 heptanaloxime C7H15NO 129.20 CCCCCCC=NO 7583-53-1 (1-methyl-piperidin-3-yl)-methanol C7H15NO 129.20 OCC(CCC1)CN1C 622-26-4 4-piperidineethanol C7H15NO 129.20 OCCC1CCNCC1 13444-24-1 1-ETHYL-3-PIPERIDINOL C7H15NO 129.20 CCN(CCC1)CC1O 628-62-6 OENANTHSAEUREAMID C7H15NO 129.20 CCCCCCC(=O)N 1484-84-0 2-(2-HYDROXYETHYL)-PIPERIDIN C7H15NO 129.20 OCCC1CCCCN1 3040-44-6 1-PIPERIDINETHANOL C7H15NO 129.20 OCCN1CCCCC1 24331-71-3 N,N,2,2-TETRAMETHYLPROPANAMID C7H15NO 129.20 CC(C)(C)C(=O)N(C)C 1114-51-8 N,N-DIETHYLPROPANAMID C7H15NO 129.20 CCN(CC)C(CC)=O 140-31-8 N-(2-AMINOETHYL)-PIPERAZIN C6H15N3 129.20 NCCN1CCNCC1 13070-07-0 2-piperidinethione,1-methyl- C6H11NS 129.22 CN1CCCCC1=S 629-12-9 1-isothiocyanatopentane C6H11NS 129.22 CCCCCN=C=S 628-03-5 1-isothiocyanato-3-methylbutane C6H11NS 129.22 CC(C)CCN=C=S 626-23-3 N-(1-METHYLPROPYL)-2-BUTANAMIN C8H19N 129.24 CCC(C)NC(C)CC 110-96-3 2-METHYL-N-(2-METHYLPROPYL)-1-PROPANAMIN C8H19N 129.24 CC(C)CNCC(C)C 111-92-2 N-BUTYL-1-BUTANAMIN C8H19N 129.24 CCCCNCCCC 104-75-6 2-ETHYL-1-HEXANAMIN C8H19N 129.24 CCCCC(CN)CC 111-86-4 1-OCTANAMIN C8H19N 129.24 NCCCCCCCC 543-82-8 6-METHYL-2-HEPTANAMIN C8H19N 129.24 NC(C)CCCC(C)C 7087-68-5 N-ETHYL-N-(1-METHYLETHYL)-2-ISOPROPANAMIN C8H19N 129.24 CCN(C(C)C)C(C)C 74-97-5 BROMCHLORMETHAN CH2BrCl 129.38 ClCBr 51-21-8 5-FLUOR-2,4(1H,3H)-PYRIMIDINDION C4H3FN2O2 130.08 Fc1c[nH]c(=O)[nH]c1=O

Page 48 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 28177-48-2 phenol,2,6-difluoro- C6H4F2O 130.09 Fc1cccc(F)c1O 498-23-7 (2Z)-2-METHYL-2-BUTENDISAEURE C5H6O4 130.10 OC(=O)C=C(C)C(O)=O 498-24-8 (e)-2-methyl-2-butenedioicacid C5H6O4 130.10 OC(=O)C=C(C)C(O)=O 97-65-4 METHYLENBUTANDISAEURE C5H6O4 130.10 OC(=O)CC(=C)C(O)=O 123-62-6 PROPANSAEUREANHYDRID C6H10O3 130.14 CCC(OC(CC)=O)=O 815-17-8 3,3-dimethyl-2-oxobutanoicacid C6H10O3 130.14 CC(C)(C)C(=O)C(O)=O 141-97-9 ACETESSIGSAEUREETHYLESTER C6H10O3 130.14 CCOC(CC(C)=O)=O 868-77-9 METHACRYLSAEURE-2-HYDROXYETHYLESTER C6H10O3 130.14 OCCOC(=O)C(C)=C 999-61-1 2-hydroxypropylacrylate C6H10O3 130.14 OC(C)COC(=O)C=C 332-77-4 2,5-DIHYDRO-2,5-DIMETHOXYFURAN C6H10O3 130.14 COC1C=CC(OC)O1 599-04-2 PANTOLACTON C6H10O3 130.14 CC1(C)COC(C1O)=O 624-45-3 LAEVULINSAEUREMETHYLESTER C6H10O3 130.14 COC(CCC(C)=O)=O 3128-06-1 5-OXOHEXANSAEURE C6H10O3 130.14 OC(CCCC(C)=O)=O 91-19-0 CHINOXALIN C8H6N2 130.15 c2nc1ccccc1nc2 253-82-7 CHINAZOLIN C8H6N2 130.15 c2nc1ccccc1cn2 254-79-5 1,5-naphthyridine C8H6N2 130.15 c(ccc1nc2)nc1cc2 253-66-7 cinnoline C8H6N2 130.15 n2nc1ccccc1cc2 253-52-1 PHTHALAZIN C8H6N2 130.15 n2cc1ccccc1cn2 15962-47-7 (2S)-2-(ACETYLAMINO)PROPANAMID C5H10N2O2 130.15 CC(NC(C)=O)C(=O)N 39972-78-6 PEROXIDE,1,1-DIMETHYLETHYL2-PROPENYL C7H14O2 130.19 CC(C)(C)OOCC=C 1185-39-3 2,2-DIMETHYLPENTANSAEURE C7H14O2 130.19 CCCC(C)(C)C(O)=O 4536-23-6 HEXANOICACID,2-METHYL- C7H14O2 130.19 CCCCC(C)C(O)=O 629-33-4 AMEISENSAEUREHEXYLESTER C7H14O2 130.19 CCCCCCOC=O 111-14-8 HEPTANSAEURE C7H14O2 130.19 CCCCCCC(O)=O 628-46-6 5-methylhexanoicacid C7H14O2 130.19 CC(C)CCCC(O)=O 20487-40-5 PROPANSAEURE-1,1-DIMETHYLETHYLESTER C7H14O2 130.19 CC(C)(C)OC(CC)=O 816-11-5 2-ETHYLBUTANSAEUREMETHYLESTER C7H14O2 130.19 CCC(CC)C(OC)=O 540-42-1 PROPANSAEURE-2-METHYLPROPYLESTER C7H14O2 130.19 CC(C)COC(CC)=O 591-34-4 PROPANSAEURE-1-METHYLPROPYLESTER C7H14O2 130.19 CCC(C)OC(CC)=O 644-49-5 2-METHYLPROPANSAEUREPROPYLESTER C7H14O2 130.19 CCCOC(C(C)C)=O 617-50-5 2-METHYLPROPANSAEURE-1-METHYLETHYLESTER C7H14O2 130.19 CC(C)OC(C(C)C)=O 638-11-9 BUTANSAEURE-1-METHYLETHYLESTER C7H14O2 130.19 CCCC(OC(C)C)=O 106-70-7 HEXANSAEUREMETHYLESTER C7H14O2 130.19 CCCCCC(OC)=O 590-01-2 PROPANSAEUREBUTYLESTER C7H14O2 130.19 CCCCOC(CC)=O 108-64-5 3-METHYLBUTANSAEUREETHYLESTER C7H14O2 130.19 CCOC(CC(C)C)=O 105-66-8 BUTANSAEUREPROPYLESTER C7H14O2 130.19 CCCOC(CCC)=O 539-82-2 PENTANSAEUREETHYLESTER C7H14O2 130.19 CCCCC(OCC)=O 625-16-1 2-METHYL-2-BUTANOLACETAT C7H14O2 130.19 CCC(C)(C)OC(C)=O 3938-95-2 2,2-DIMETHYLPROPANSAEUREETHYLESTER C7H14O2 130.19 CCOC(C(C)(C)C)=O 628-63-7 ESSIGSAEUREPENTYLESTER C7H14O2 130.19 CCCCCOC(C)=O 626-38-0 (1-METHYLBUTYL)-ACETAT C7H14O2 130.19 CCCC(C)OC(C)=O 123-92-2 3-METHYL-1-BUTANOLACETAT C7H14O2 130.19 CC(C)CCOC(C)=O 624-41-9 ESSIGSAEURE-2-METHYLBUTYLESTER C7H14O2 130.19 CCC(C)COC(C)=O 1005-51-2 TRICYCLO[3.3.2.0(4,6)]DECA-2,7,9-TRIENE C10H10 130.19 C(C1C3C=CC2C=CC31)=C2 3054-95-3 1-propene,3,3-diethoxy- C7H14O2 130.19 CCOC(OCC)C=C 2426-08-6 (BUTOXYMETHYL)OXIRAN C7H14O2 130.19 CCCCOCC1OC1 107-70-0 4-METHOXY-4-METHYL-2-PENTANON C7H14O2 130.19 COC(C)(C)CC(C)=O 7665-72-7 1-TERT.-BUTOXY-2,3-EPOXY-PROPAN C7H14O2 130.19 CC(C)(C)OCC1OC1 621-64-7 N-NITROSO-N-PROPYL-1-PROPANAMIN C6H14N2O 130.19 CCCN(CCC)N=O 601-77-4 di-i-propylnitrosoamine C6H14N2O 130.19 CC(C)N(C(C)C)N=O 6317-18-6 methylenebisthiocyanate C3H2N2S2 130.19 N#CSCSC#N 103-76-4 N-(2-HYDROXYETHYL)-PIPERAZIN C6H14N2O 130.19 OCCN1CCNCC1 2038-03-1 4-MORPHOLINEETHANAMINE C6H14N2O 130.19 NCCN1CCOCC1 373-04-6 HEXANAMIDE,6-AMINO C6H14N2O 130.19 NCCCCCC(=O)N 105-06-6 1,4-DIETHENYLBENZOL C10H10 130.19 C=Cc1ccc(C=C)cc1 108-57-6 1,3-DIETHENYLBENZOL C10H10 130.19 C=Cc1cc(C=C)ccc1 2177-47-1 2-METHYL-1H-INDEN C10H10 130.19 CC(Cc1cc2)=Cc1cc2 612-17-9 1,4-DIHYDRONAPHTHALIN C10H10 130.19 C2c1ccccc1CC=C2 767-59-9 1-METHYL-1H-INDEN C10H10 130.19 CC1C=Cc2c1cccc2 447-53-0 1,2-DIHYDRONAPHTHALIN C10H10 130.19 C2C=Cc1ccccc1C2 767-60-2 3-METHYL-1H-INDEN C10H10 130.19 CC1=CCc2c1cccc2 142-96-1 DIBUTYLETHER C8H18O 130.23 CCCCOCCCC

Page 49 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 6163-66-2 DI-TERT.-BUTYLETHER C8H18O 130.23 CC(C)(C)OC(C)(C)C 5756-43-4 1-ETHOXYHEXAN C8H18O 130.23 CCOCCCCCC 32970-45-9 SEK.-BUTYL-TERT.-BUTYLETHER C8H18O 130.23 CCC(C)OC(C)(C)C 6863-58-7 DI-SEK.-BUTYLETHER C8H18O 130.23 CCC(C)OC(C)CC 3054-92-0 2,3,4-TRIMETHYL-3-PENTANOL C8H18O 130.23 CC(C)C(O)(C)C(C)C 14979-39-6 4-METHYL-3-HEPTANOL C8H18O 130.23 CCCC(C)C(O)CC 3730-60-7 2,5-DIMETHYL-2-HEXANOL C8H18O 130.23 CC(C)CCC(O)(C)C 625-25-2 2-METHYL-2-HEPTANOL C8H18O 130.23 CCCCCC(O)(C)C 1838-73-9 3-METHYL-4-HEPTANOL C8H18O 130.23 CCCC(O)C(C)CC 7294-05-5 2,2,3-TRIMETHYL-3-PENTANOL C8H18O 130.23 CCC(O)(C)C(C)(C)C 26952-21-6 isooctylalcohol C8H18O 130.23 OCCCCCC(C)C 18720-62-2 2-METHYL-3-HEPTANOL C8H18O 130.23 CCCCC(O)C(C)C 33021-02-2 ISOBUTYL-TERT.-BUTYLETHER C8H18O 130.23 CC(C)COC(C)(C)C 598-01-6 4-METHYL-4-HEPTANOL C8H18O 130.23 CCCC(O)(C)CCC 111-87-5 1-OCTANOL C8H18O 130.23 OCCCCCCCC 18720-66-6 6-METHYL-3-HEPTANOL C8H18O 130.23 CCC(O)CCC(C)C 4209-90-9 2,2-DIMETHYL-3-HEXANOL C8H18O 130.23 CCCC(O)C(C)(C)C 20296-29-1 3-octanol,(.+-.)- C8H18O 130.23 CCCCCC(O)CC 29063-28-3 octanol(isomermix) C8H18O 130.23 CCCCCC(O)CC 589-98-0 3-OCTANOL C8H18O 130.23 CCCCCC(O)CC 589-62-8 4-OCTANOL C8H18O 130.23 CCCCC(O)CCC 123-96-6 2-OCTANOL C8H18O 130.23 CCCCCCC(O)C 110-95-2 N,N,N`,N`-TETRAMETHYL-1,3-DIAMINOPROPAN C7H18N2 130.23 CN(C)CCCN(C)C 597-05-7 3-ETHYL-2-METHYL-3-PENTANOL C8H18O 130.23 CCC(O)(CC)C(C)C 597-76-2 3-ETHYL-3-HEXANOL C8H18O 130.23 CCCC(O)(CC)CC 104-78-9 3-DIETHYLAMINOPROPYLAMIN C7H18N2 130.23 NCCCN(CC)CC 646-19-5 1,7-HEPTANDIAMIN C7H18N2 130.23 NCCCCCCCN 60435-70-3 2-METHYL-1-HEPTANOL C8H18O 130.23 CCCCCC(C)CO 104-76-7 2-ETHYL-1-HEXANOL C8H18O 130.23 CCCCC(CO)CC 628-55-7 DIISOBUTYLETHER C8H18O 130.23 CC(C)COCC(C)C 5356-83-2 silane,ethenylethoxydimethyl- C6H14OSi 130.26 CCO[Si](C)(C)C=C 1000-49-3 TRIMETHYLBUTYLSILAN C7H18Si 130.30 CCCC[Si](C)(C)C 76-04-0 aceticacid,chlorodifluoro- C2HClF2O2 130.48 FC(F)(Cl)C(O)=O 527-69-5 2-furancarbonylchloride C5H3ClO2 130.53 ClC(=O)c1occc1 352-33-0 1-CHLOR-4-FLUORBENZOL C6H4ClF 130.55 Fc1ccc(Cl)cc1 625-98-9 1-CHLOR-3-FLUORBENZOL C6H4ClF 130.55 Fc1cc(Cl)ccc1 348-51-6 1-CHLOR-2-FLUORBENZOL C6H4ClF 130.55 Fc1ccccc1Cl 54454-10-3 1,3-dimethyl-5-chloropyrazole C5H7ClN2 130.58 Cc(nn1C)cc1Cl 1511-62-2 BROMDIFLUORMETHAN CHBrF2 130.92 FC(F)Br 420-97-3 1,2-DICHLOR-2-FLUORPROPAN C3H5Cl2F 130.98 ClCC(F)(C)Cl 613-90-1 PHENYLGLYOXYLSAEURENITRIL C8H5NO 131.13 N#CC(c1ccccc1)=O 105-07-7 benzonitrile,4-formyl- C8H5NO 131.13 N#Cc1ccc(C=O)cc1 24964-64-5 m-cyanobenazldehyde C8H5NO 131.13 N#Cc1cc(C=O)ccc1 51-35-4 (4R)-4-HYDROXY-L-PROLIN C5H9NO3 131.13 OC1CC(NC1)C(O)=O 57-00-1 N-(AMINOIMINOMETHYL)-N-METHYLGLYCIN C4H9N3O2 131.13 OC(=O)CN(C)C(=N)N 254-87-5 1,2,4-benzotriazine C7H5N3 131.14 n2nc1ccccc1nc2 322-46-3 pyrido(2,3)pyrazine C7H5N3 131.14 c2nc1ncccc1nc2 646-14-0 1-NITROHEXAN C6H13NO2 131.17 CCCCCCN(=O)=O 543-86-2 3-METHYL-1-BUTANOLCARBAMAT C6H13NO2 131.17 CCCCOC(=O)NC 590-60-3 2-methyl-2-butanolcarbamate C6H13NO2 131.17 CCC(C)(C)OC(=O)N 33105-81-6 t-butylglycine C6H13NO2 131.17 CC(C)(C)C(N)C(O)=O 616-06-8 NORLEUCIN C6H13NO2 131.17 CCCCC(N)C(O)=O 327-57-1 L-NORLEUCIN C6H13NO2 131.17 CCCCC(N)C(O)=O 622-40-2 2-MORPHOLINOETHANOL C6H13NO2 131.17 OCCN1CCOCC1 73-32-5 2-AMINO-3-METHYLVALERIANSAEURE C6H13NO2 131.17 CCC(C)C([NH3+])C([O-])=O 61-90-5 L-LEUCIN C6H13NO2 131.17 CC(C)CC([NH3+])C([O-])=O 60-32-2 6-AMINOHEXANSAEURE C6H13NO2 131.17 [NH3+]CCCCCC([O-])=O 603-76-9 1-METHYL-1H-INDOL C9H9N 131.18 Cn1ccc2c1cccc2 6575-13-9 2,6-DIMETHYLBENZONITRIL C9H9N 131.18 Cc1cccc(C)c1C#N 21789-36-6 2,4-DIMETHYLBENZONITRIL C9H9N 131.18 Cc(ccc1C#N)cc1C 1823-91-2 2-PHENYL-PROPIONITRIL C9H9N 131.18 CC(C#N)c1ccccc1 22364-68-7 o-tolyl-acetonitrile C9H9N 131.18 N#CCc1ccccc1C

Page 50 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 2947-60-6 1-methyl-3-cyanomethylbenzene C9H9N 131.18 N#CCc(ccc1)cc1C 2947-61-7 4-METHYLPHENYLETHANNITRIL C9H9N 131.18 N#CCc(cc1)ccc1C 645-59-0 BENZOLPROPANNITRIL C9H9N 131.18 N#CCCc1ccccc1 83-34-1 3-METHYL-1H-INDOL C9H9N 131.18 Cc1c[nH]c2c1cccc2 622-93-5 3-(DIETHYLAMINO)-1-PROPANOL C7H17NO 131.22 OCCCN(CC)CC 56-18-8 BIS-(3-AMINOPROPYL)-AMIN C6H17N3 131.22 NCCCNCCCN 18187-14-9 1-propanamine,3-(trimethylsilyl)- C6H17NSi 131.29 NCCC[Si](C)(C)C 7440-63-3 XENON Xe 131.29 [Xe] 79-01-6 TRICHLORETHEN C2HCl3 131.39 ClC=C(Cl)Cl 76-37-9 1,1,3-TRIHYDROPERFLUOR-1-PROPANOL C3H4F4O 132.06 OCC(F)(F)C(F)F 425-88-7 METHYL1,1,2,2-TETRAFLUOROETHYLETHER C3H4F4O 132.06 COC(F)(F)C(F)F 328-42-7 OXOBUTANDISAEURE C4H4O5 132.07 OC(=O)CC(=O)C(O)=O 4122-45-6 4,5-DIHYDRO-3-NITROISOXAZOL-2-OXID C3H4N2O4 132.08 O=N1=C(CCO1)N(=O)=O 367-23-7 1,2,4-TRIFLUORBENZOL C6H3F3 132.08 Fc(ccc1F)cc1F 372-38-3 1,3,5-TRIFLUORBENZOL C6H3F3 132.08 Fc1cc(F)cc(F)c1 615-53-2 METHYLNITROSOCARBAMIDSAEUREETHYLESTER C4H8N2O3 132.12 CCOC(=O)N(C)N=O 108-59-8 PROPANDISAEUREDIMETHYLESTER C5H8O4 132.12 COC(CC(OC)=O)=O 595-46-0 DIMETHYLPROPANDISAEURE C5H8O4 132.12 CC(C)(C(O)=O)C(O)=O 601-75-2 ETHYLPROPANDISAEURE C5H8O4 132.12 CCC(C(O)=O)C(O)=O 3878-55-5 BUTANDISAEUREMONOMETHYLESTER C5H8O4 132.12 COC(CCC(O)=O)=O 4164-32-3 morpholine,4-nitro- C4H8N2O3 132.12 O=N(=O)N1CCOCC1 498-21-5 METHYLBUTANDISAEURE C5H8O4 132.12 CC(CC(O)=O)C(O)=O 626-36-8 carbamicacid,(aminocarbonyl)-,ethylester C4H8N2O3 132.12 CCOC(=O)NC(=O)N 110-94-1 PENTANDISAEURE C5H8O4 132.12 OC(CCCC(O)=O)=O 91-18-9 pteridine C6H4N4 132.12 c2nc1nccnc1cn2 556-50-3 N-GLYCYLGLYCIN C4H8N2O3 132.12 OC(=O)CNC(CN)=O 868-54-2 1-propene-1,1,3-tricarbonitrile,2-amino- C6H4N4 132.12 N#CCC(N)=C(C#N)C#N 70-47-3 L-ASPARAGIN C4H8N2O3 132.12 [NH3+]C(CC(=O)N)C([O-])=O 254-04-6 2H-1-BENZOPYRAN C9H8O 132.16 C2C=Cc1ccccc1O2 3639-21-2 butanoicacid,2-ethyl-2-hydroxy- C6H12O3 132.16 CCC(O)(CC)C(O)=O 6064-63-7 DL-2-HYDROXYHEXANSAEURE C6H12O3 132.16 CCCCC(O)C(O)=O 1191-25-9 6-HYDROXYHEXANSAEURE C6H12O3 132.16 OCCCCCC(O)=O 768-22-9 6,6a-dihydro-1a-oxir(a)indene C9H8O 132.16 O(C31)C1c2ccccc2C3 768-03-6 acrylophenone C9H8O 132.16 C=CC(c1ccccc1)=O 616-09-1 2-HYDROXYPROPANSAEUREPROPYLESTER C6H12O3 132.16 CCCOC(C(O)C)=O 123-63-7 2,4,6-TRIMETHYLTRIOXAN C6H12O3 132.16 CC1OC(C)OC(C)O1 80-55-7 propanoicacid,2-hydroxy-2-methyl-,ethylester C6H12O3 132.16 CCOC(C(O)(C)C)=O 615-13-4 1,3-DIHYDRO-2H-INDEN-2-ONE C9H8O 132.16 O=C(Cc1cc2)Cc1cc2 4187-87-5 ALPHA-ETHYNYLBENZOLMETHANOL C9H8O 132.16 OC(C#C)c1ccccc1 100-79-8 2,2-DIMETHYL-1,3-DIOXOLAN-4-METHANOL C6H12O3 132.16 OCC(CO1)OC1(C)C 5405-41-4 3-HYDROXYBUTANSAEUREETHYLESTER C6H12O3 132.16 CCOC(CC(O)C)=O 53951-43-2 2,4-dimethyl-1,3-dioxolane-2-methanol C6H12O3 132.16 OCC1(C)OC(C)CO1 108-65-6 1-METHOXYPROPYL-2-ACETAT C6H12O3 132.16 COCC(C)OC(C)=O 696-59-3 TETRAHYDRO-2,5-DIMETHOXYFURAN C6H12O3 132.16 COC1OC(OC)CC1 111-15-9 ETHYLGLYKOLACETAT C6H12O3 132.16 CCOCCOC(C)=O 83-33-0 2,3-DIHYDRO-1H-INDEN-1-ON C9H8O 132.16 O=C1CCc2c1cccc2 817-95-8 ETHOXYESSIGSAEUREETHYLESTER C6H12O3 132.16 CCOCC(OCC)=O 104-55-2 3-PHENYL-2-PROPENAL C9H8O 132.16 O=CC=Cc1ccccc1 615-15-6 2-METHYL-1H-BENZIMIDAZOL C8H8N2 132.16 Cc(nc1cc2)[nH]c1cc2 5192-03-0 5-aminoindole C8H8N2 132.16 Nc2cc1cc[nH]c1cc2 3544-25-0 (4-amino-phenyl)-acetonitrile C8H8N2 132.16 N#CCc(cc1)ccc1N 4265-25-2 2-METHYLBENZOFURAN C9H8O 132.16 Cc2oc1ccccc1c2 70-26-8 (S)-ALPHA-DELTA-DIAMINOVALERIANSAEURE C5H12N2O2 132.16 [NH3+]CCCC(N)C([O-])=O 6007-71-2 2,5-dihydro-2-methyl-thiophene1,1-dioxide C5H8O2S 132.18 CC1C=CCS1(=O)=O 1193-10-8 1,1-DIOXID-2,5-DIHYDRO-4-METHYLTHIOPHEN C5H8O2S 132.18 CC(=CC1)CS1(=O)=O 115-76-4 2,2-DIETHYL-1,3-PROPANDIOL C7H16O2 132.20 OCC(CO)(CC)CC 505-84-0 DIPROPOXYMETHAN C7H16O2 132.20 CCCOCOCCC 78-26-2 2-METHYL-2-PROPYL-1,3-PROPANDIOL C7H16O2 132.20 CCCC(C)(CO)CO 629-30-1 1,7-HEPTANDIOL C7H16O2 132.20 OCCCCCCCO 4744-08-5 1,1-DIETHOXYPROPAN C7H16O2 132.20 CCOC(CC)OCC 94023-15-1 TERT.-MONOBUTYLETHER_VON_1,2-PROPANDIOL C7H16O2 132.20 OCC(C)OC(C)(C)C 6196-58-3 ETHYLENGLYKOLMONOPENTYLETHER C7H16O2 132.20 OCCOCCCCC

Page 51 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 5131-66-8 1-BUTOXY-2-PROPANOL C7H16O2 132.20 CCCCOCC(O)C 126-84-1 2,2-DIETHOXYPROPAN C7H16O2 132.20 CCOC(C)(C)OCC 57018-52-7 1-(1,1-DIMETHYLETHOXY)-2-PROPANOL C7H16O2 132.20 OC(C)COC(C)(C)C 768-56-9 3-BUTENYLBENZOL C10H12 132.20 C=CCCc1ccccc1 1587-04-8 1-methyl-2-(2-propenyl)benzene C10H12 132.20 C=CCc1ccccc1C 7564-63-8 1-ETHENYL-2-ETHYLBENZOL C10H12 132.20 CCc1ccccc1C=C 3454-07-7 (4-ETHYLPHENYL)ETHEN C10H12 132.20 CCc1ccc(C=C)cc1 1005-64-7 TRANS-1-PHENYL-1-BUTEN C10H12 132.20 CCC=Cc1ccccc1 7525-62-4 1-ETHENYL-3-ETHYLBENZOL C10H12 132.20 CCc1cc(C=C)ccc1 768-00-3 BENZENE,(1-METHYL-1-PROPENYL)-,(E)- C10H12 132.20 CC=C(C)c1ccccc1 1124-20-5 3-ISOPROPENYLTOLUOL C10H12 132.20 CC(=C)c(ccc1)cc1C 1195-32-0 2-(4-METHYLPHENYL)-PROPEN C10H12 132.20 CC(=C)c(cc1)ccc1C 768-49-0 2-METHYL-1-PHENYLPROPEN C10H12 132.20 CC(C)=Cc1ccccc1 1560-06-1 2-butenylbenzene C10H12 132.20 CC=CCc1ccccc1 2039-93-2 (1-METHYLENPROPYL)BENZOL C10H12 132.20 CCC(=C)c1ccccc1 3451-55-6 1,2,6,7-CYCLODECATETRAEN C10H12 132.20 C1C=C=CCCC=C=CC1 767-99-7 BENZENE,(1-METHYL-1-PROPENYL)-,(Z) C10H12 132.20 CC=C(C)c1ccccc1 119-64-2 TETRALIN C10H12 132.20 C(CCc1cc2)Cc1cc2 824-22-6 2,3-DIHYDRO-4-METHYL-1H-INDEN C10H12 132.20 Cc2c1CCCc1ccc2 767-58-8 2,3-DIHYDRO-1-METHYL-1H-INDEN C10H12 132.20 CC1CCc2c1cccc2 824-63-5 2,3-DIHYDRO-2-METHYL-1H-INDEN C10H12 132.20 CC(Cc1cc2)Cc1cc2 874-35-1 2,3-DIHYDRO-5-METHYL-1H-INDEN C10H12 132.20 Cc2cc1CCCc1cc2 77-73-6 3A,4,7,7A-TETRAHYDRO-4,7-METHANO-1H-INDEN C10H12 132.20 C2C1C4C3C=CCC3C2C41 19872-52-7 4-methyl-4-sulfanylpentan-2-one C6H12OS 132.22 CC(C)(S)CC(C)=O 463-11-6 1-FLUOROCTAN C8H17F 132.22 FCCCCCCCC 2782-91-4 N,N,N`,N`-TETRAMETHYLTHIOHARNSTOFF C5H12N2S 132.23 CN(C)C(=S)N(C)C 105-55-5 N,N`-DIETHYLTHIOHARNSTOFF C5H12N2S 132.23 CCNC(=S)NCC 26158-99-6 1-(ETHYLTHIO)PENTAN C7H16S 132.27 CCCCCSCC 1639-09-4 1-HEPTANTHIOL C7H16S 132.27 CCCCCCCS 2917-47-7 propanol-trimethylsilane C6H16OSi 132.28 OCCC[Si](C)(C)C 597-52-4 TRIETHYLSILANOL C6H16OSi 132.28 CC[Si](O)(CC)CC 96-02-6 3-CHLOR-2,5-FURANDION C4HClO3 132.50 ClC1=CC(OC1=O)=O 460-35-5 1-CHLOR-3,3,3-TRIFLUORPROPAN C3H4ClF3 132.51 ClCCC(F)(F)F 822-87-7 2-CHLORCYCLOHEXANON C6H9ClO 132.59 ClC1CCCCC1=O 865-52-1 TETRAMETHYLGERMAN C4H12Ge 132.78 C[Ge](C)(C)C 768403-89-0 isobutylgermane C4H12Ge 132.78 [GeH3]CC(C)C 676-97-1 methylphosphonyldichloride CH3Cl2OP 132.91 CP(Cl)(Cl)=O 79-35-6 1,1-DIFLUOR-2,2-DICHLORETHEN C2Cl2F2 132.92 FC(F)=C(Cl)Cl 598-88-9 1,2-DICHLOR-1,2-DIFLUOR-ETHEN C2Cl2F2 132.92 FC(Cl)=C(F)Cl 142-73-4 N-(CARBOXYMETHYL)GLYCIN C4H7NO4 133.10 OC(CNCC(O)=O)=O 56-84-8 L-ASPARAGINSAEURE C4H7NO4 133.10 OC(CC([NH3+])C([O-])=O)=O 6609-56-9 2-methoxy-benzonitrile C8H7NO 133.15 COc1ccccc1C#N 874-90-8 4-METHOXYBENZONITRIL C8H7NO 133.15 COc1ccc(C#N)cc1 532-28-5 ALPHA-HYDROXYBENZOLACETONITRIL C8H7NO 133.15 OC(C#N)c1ccccc1 14191-95-8 4-hydroxybenzylcyanide C8H7NO 133.15 N#CCc(cc1)ccc1O 59-48-3 oxindole C8H7NO 133.15 O=C(Cc1cc2)Nc1cc2 1953-54-4 1H-INDOL-5-OL C8H7NO 133.15 Oc2cc1cc[nH]c1cc2 19335-11-6 1h-indazol-5-amine C7H7N3 133.15 Nc2cc1cn[nH]c1cc2 480-91-1 2,3-dihydro-1h-isoindol-1-one C8H7NO 133.15 O=C(c1cc2)NCc1cc2 614-68-6 benzene,1-isocyanato-2-methyl- C8H7NO 133.15 Cc1ccccc1N=C=O 543-87-3 3-METHYL-1-BUTANOLNITRAT C5H11NO3 133.15 CC(C)CCON(=O)=O 1002-16-0 N-AMYLNITRAT C5H11NO3 133.15 CCCCCON(=O)=O 444-27-9 4-thiazolidinecarboxylicacid C4H7NO2S 133.17 OC(C1CSCN1)=O 635-46-1 1,2,3,4-TETRAHYDROCHINOLIN C9H11N 133.19 C2Nc1ccccc1CC2 589-09-3 N-2-PROPENYLBENZOLAMIN C9H11N 133.19 C=CCNc1ccccc1 110-97-4 DIISOPROPANOLAMIN C6H15NO2 133.19 OC(C)CNCC(O)C 24425-40-9 indan-5-ylamine C9H11N 133.19 Nc2cc1CCCc1cc2 139-87-7 ETHYLDIETHANOLAMIN C6H15NO2 133.19 OCCN(CC)CCO 141-84-4 4-thiazolidinone,2-thioxo- C3H3NOS2 133.19 O=C1NC(SC1)=S 155-09-9 tranylcypromine C9H11N 133.19 NC1CC1c2ccccc2 91-21-4 1,2,3,4-TETRAHYDROISOCHINOLIN C9H11N 133.19 N2Cc1ccccc1CC2 645-36-3 ethanamine,2,2-diethoxy- C6H15NO2 133.19 CCOC(CN)OCC

Page 52 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 79-00-5 1,1,2-TRICHLORETHAN C2H3Cl3 133.41 ClCC(Cl)Cl 71-55-6 1,1,1-TRICHLORETHAN C2H3Cl3 133.41 CC(Cl)(Cl)Cl 128-09-6 N-CHLOR-SUCCINIMID C4H4ClNO2 133.53 ClN1C(CCC1=O)=O 679-86-7 1,1,2,2,3-PENTAFLUORPENTAN C3H3F5 134.05 FCC(F)(F)C(F)F 460-73-1 1,1,1,3,3-PENTAFLUORPROPAN(R245FA) C3H3F5 134.05 FC(F)CC(F)(F)F 692-42-2 DIETHYLARSIN C4H11As 134.05 CC[AsH]CC 1814-88-6 1,1,1,2,2-PENTAFLUORPROPAN C3H3F5 134.05 FC(F)(F)C(F)(F)C 696-82-2 2,4,6-trifluoropyrimidine C4HF3N2 134.06 Fc1nc(F)cc(F)n1 97-67-6 (S)-HYDROXYBUTANDISAEURE C4H6O5 134.09 OC(CC(O)=O)C(O)=O 110-99-6 DIGLYKOLSAEURE C4H6O5 134.09 OC(COCC(O)=O)=O 553-86-6 3h-benzofuran-2-one C8H6O2 134.13 O=C2Cc1ccccc1O2 4767-03-7 propanoicacid,3-hydroxy-2-(hydroxymethyl)-2-me C5H10O4 134.13 OCC(C)(CO)C(O)=O 623-27-8 1,4-BENZENEDICARBOXALDEHYDE C8H6O2 134.13 O=Cc1ccc(C=O)cc1 626-19-7 1,3-diformylbenzene C8H6O2 134.13 O=Cc1cc(C=O)ccc1 87-41-2 1(3H)-ISOBENZOFURANON C8H6O2 134.13 O=C2c1ccccc1CO2 26446-35-5 1,2,3-PROPANTRIOLMONOACETAT C5H10O4 134.13 OCC(O)COC(C)=O 1116-54-7 n-nitrosodiethanolamine C4H10N2O3 134.13 OCCN(CCO)N=O 533-67-5 2-DEOXY-D-ERYTHRO-PENTOSE C5H10O4 134.13 OCC(O)C(O)CC=O 615-16-7 o-phenyleneurea C7H6N2O 134.14 O=C2Nc1ccccc1N2 7327-60-8 ACETONITRILE,2,2,2-NITRILOTRIS- C6H6N4 134.14 N#CCN(CC#N)CC#N 77-99-6 1,1,1-TRIMETHYLOLPROPAN C6H14O3 134.17 OCC(CO)(CO)CC 621-63-6 2,2-diethoxyethanol C6H14O3 134.17 CCOC(CO)OCC 14315-97-0 1,1,3-trimethoxypropane C6H14O3 134.17 COCCC(OC)OC 25265-71-8 DIPROPYLENGLYKOL(ISOMERENGEMISCH) C6H14O3 134.17 OC(C)COCC(O)C 110-98-5 BIS-(2-HYDROXYPROPYL)-ETHER C6H14O3 134.17 OC(C)COCC(O)C 111-90-0 2-(2-ETHOXYETHOXY)ETHANOL C6H14O3 134.17 OCCOCCOCC 111-96-6 DIETHYLENGLYKOLDIMETHYLETHER C6H14O3 134.17 COCCOCCOC 106-69-4 1,2,6-HEXANTRIOL C6H14O3 134.17 OCCCCC(O)CO 1746-11-8 2,3-DIHYDRO-2-METHYLBENZOFURAN C9H10O 134.18 CC2Cc1ccccc1O2 493-08-3 3,4-DIHYDRO-2H-1-BENZOPYRAN C9H10O 134.18 C2Oc1ccccc1CC2 637-69-4 4-VINYLANISOL C9H10O 134.18 COc1ccc(C=C)cc1 1745-81-9 2-(2-PROPENYL)PHENOL C9H10O 134.18 C=CCc1ccccc1O 6351-10-6 2,3-DIHYDRO-1H-INDEN-1-OL C9H10O 134.18 OC1CCc2c1cccc2 1746-13-0 (2-PROPENYLOXY)BENZOL C9H10O 134.18 C=CCOc1ccccc1 93-53-8 ALPHA-METHYLBENZOLACETALDEHYD C9H10O 134.18 CC(C=O)c1ccccc1 5779-94-2 benzaldehyde,2,5-dimethyl- C9H10O 134.18 Cc(ccc1C)cc1C=O 104-09-6 4-methylbenzeneacetaldehyde C9H10O 134.18 O=CCc(cc1)ccc1C 104-53-0 BENZOLPROPANAL C9H10O 134.18 O=CCCc1ccccc1 93-55-0 1-PHENYL-1-PROPANON C9H10O 134.18 CCC(=O)c1ccccc1 4407-36-7 2-propen-1-ol,3-phenyl-,(e)- C9H10O 134.18 OCC=Cc1ccccc1 4748-78-1 4-ethylbenzaldehyde C9H10O 134.18 CCc1ccc(C=O)cc1 15764-16-6 2,4-DIMETHYLBENZALDEHYD C9H10O 134.18 Cc(ccc1C=O)cc1C 577-16-2 1-(2-METHYLPHENYL)ETHANON C9H10O 134.18 CC(=O)c1ccccc1C 585-74-0 1-(3-METHYLPHENYL)ETHANON C9H10O 134.18 CC(=O)c(ccc1)cc1C 122-00-9 1-(4-METHYLPHENYL)ETHANON C9H10O 134.18 CC(=O)c(cc1)ccc1C 103-79-7 BENZYLMETHYLKETON C9H10O 134.18 CC(=O)Cc1ccccc1 3476-89-9 1,2,3,4-tetrahydroquinoxaline C8H10N2 134.18 C2Nc1ccccc1NC2 1470-94-6 5-HYDROXYINDAN C9H10O 134.18 Oc2cc1CCCc1cc2 501-92-8 4-(2-PROPENYL)PHENOL C9H10O 134.18 C=CCc(cc1)ccc1O 4286-23-1 4-(1-METHYETHENYL)PHENOL C9H10O 134.18 CC(=C)c(cc1)ccc1O 34413-35-9 5,6,7,8-tetrahydroquinoxaline C8H10N2 134.18 C(CCc1nc2)Cc1nc2 612-15-7 2-VINYLANISOL C9H10O 134.18 COc1ccccc1C=C 872-93-5 3-METHYLSULFOLAN C5H10O2S 134.20 CC(CC1)CS1(=O)=O 95-15-8 2,3-BENZOTHIOPHEN C8H6S 134.20 c(ccc1sc2)cc1c2 2870-04-4 2,6-DIMETHYLETHYLBENZOL C10H14 134.22 CCc1c(C)cccc1C 488-23-3 1,2,3,4-TETRAMETHYLBENZOL C10H14 134.22 Cc1ccc(C)c(C)c1C 98-06-6 (1,1-DIMETHYLETHYL)BENZOL C10H14 134.22 CC(C)(C)c1ccccc1 933-98-2 1,2-DIMETHYL-3-ETHYLBENZOL C10H14 134.22 CCc(cccc1C)c1C 527-84-4 2-METHYLISOPROPYLBENZOL C10H14 134.22 CC(C)c1ccccc1C 1074-17-5 1-METHYL-2-PROPYLBENZOL C10H14 134.22 CCCc1ccccc1C 135-01-3 1,2-DIETHYLBENZOL C10H14 134.22 CCc1ccccc1CC 135-98-8 (1-METHYLPROPYL)BENZOL C10H14 134.22 CCC(C)c1ccccc1

Page 53 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 95-93-2 1,2,4,5-TETRAMETHYLBENZOL C10H14 134.22 Cc1cc(C)c(C)cc1C 527-53-7 1,2,3,5-TETRAMETHYLBENZOL C10H14 134.22 Cc(cc1C)cc(C)c1C 104-51-8 BUTYLBENZOL C10H14 134.22 CCCCc1ccccc1 874-41-9 1,3-DIMETHYL-4-ETHYLBENZOL C10H14 134.22 CCc1ccc(C)cc1C 1758-88-9 2,5-DIMETHYLETHYLBENZOL C10H14 134.22 CCc1cc(C)ccc1C 535-77-3 3-METHYLISOPROPYLBENZOL C10H14 134.22 CC(C)c(ccc1)cc1C 934-80-5 1,2-DIMETHYL-4-ETHYLBENZOL C10H14 134.22 CCc(ccc1C)cc1C 99-87-6 4-ISOPROPYLTOLUOL C10H14 134.22 CC(C)c(cc1)ccc1C 1074-43-7 1-METHYL-3-PROPYLBENZOL C10H14 134.22 CCCc(ccc1)cc1C 1074-55-1 4-PROPYLTOLUOL C10H14 134.22 CCCc(cc1)ccc1C 538-93-2 (2-METHYLPROPYL)BENZOL C10H14 134.22 CC(C)Cc1ccccc1 141-93-5 1,3-DIETHYLBENZOL C10H14 134.22 CCc1cc(CC)ccc1 105-05-5 1,4-DIETHYLBENZOL C10H14 134.22 CCc1ccc(CC)cc1 934-74-7 1,3-DIMETHYL-5-ETHYLBENZOL C10H14 134.22 CCc(cc1C)cc(C)c1 94087-83-9 4-methoxy-2-methylbutane-2-thiol C6H14OS 134.24 COCCC(C)(C)S 930-35-8 1,3-dithiole-2-thione C3H2S3 134.24 S=C1SC=CS1 51755-83-0 3-sulfanylhexan-1-ol C6H14OS 134.24 OCCC(S)CCC 4253-91-2 DIPROPYLSULFOXID C6H14OS 134.24 CCCS(CCC)=O 358-43-0 TRIETHYLFLUORSILAN C6H15FSi 134.27 CC[Si](F)(CC)CC 3277-26-7 1,1,3,3-TETRAMETHYLDISILOXAN C4H14OSi2 134.32 C[SiH](C)O[SiH](C)C 142-61-0 HEXANOYLCHLORID C6H11ClO 134.60 CCCCCC(Cl)=O 7065-46-5 3,3-DIMETHYLBUTANOYLCHLORID C6H11ClO 134.60 CC(C)(C)CC(Cl)=O 2736-40-5 DIETHYLACETYLCHLORID C6H11ClO 134.60 CCC(CC)C(Cl)=O 5856-77-9 2,2-DIMETHYLBUTANOYLCHLORID C6H11ClO 134.60 CCC(C)(C)C(Cl)=O 629-06-1 1-CHLORHEPTAN C7H15Cl 134.65 CCCCCCCCl 4028-23-3 allyl-chloro-dimethylsilane C5H11ClSi 134.68 C[Si](C)(Cl)CC=C 1649-08-7 1,2-DICHLOR-1,1-DIFLUORETHAN C2H2Cl2F2 134.94 ClCC(F)(F)Cl 431-06-1 1,2-DICHLOR-1,2-DIFLUORETHAN_[R132] C2H2Cl2F2 134.94 FC(Cl)C(F)Cl 13063-43-9 propanedinitrile,dichloro- C3Cl2N2 134.95 ClC(Cl)(C#N)C#N 7791-25-5 SULFURYLCHLORID Cl2O2S 134.97 ClS(Cl)(=O)=O 5162-44-7 4-BROM-1-BUTEN C4H7Br 135.00 BrCCC=C 13294-71-8 2-BROM-2-BUTEN C4H7Br 135.00 CC=C(C)Br 675-14-9 2,4,6-TRIFLUOR-1,3,5-TRIAZIN C3F3N3 135.05 Fc1nc(F)nc(F)n1 77-49-6 2-NITRO-2-METHYLPROPANDIOL C4H9NO4 135.12 OCC(C)(CO)N(=O)=O 59-49-4 2(3H)-BENZOXAZOLON C7H5NO2 135.12 O=C2Nc1ccccc1O2 73-24-5 1H-PURIN-6-AMIN C5H5N5 135.13 Nc2c1nc[nH]c1ncn2 326-62-5 benzeneacetonitrile,2-fluoro- C8H6FN 135.14 N#CCc1ccccc1F 613-91-2 1-phenylethanoneoxime C8H9NO 135.16 ON=C(C)c1ccccc1 551-93-9 ACETYL-O-TOLUIDINE C8H9NO 135.16 CC(=O)c1ccccc1N 103-84-4 N-PHENYLACETAMID C8H9NO 135.16 CC(=O)Nc1ccccc1 94-69-9 n-(2-methylphenyl)formamide C8H9NO 135.16 Cc1ccccc1NC=O 99-03-6 1-(3-AMINOPHENYL)ETHANON C8H9NO 135.16 CC(=O)c(ccc1)cc1N 613-93-4 N-METHYLBENZAMID C8H9NO 135.16 CNC(c1ccccc1)=O 527-85-5 2-METHYLBENZAMID C8H9NO 135.16 Cc1ccccc1C(=O)N 618-47-3 3-METHYLBENZAMID C8H9NO 135.16 Cc1cc(ccc1)C(=O)N 619-55-6 4-METHYLBENZAMID C8H9NO 135.16 Cc1ccc(cc1)C(=O)N 99-92-3 1-(4-AMINOPHENYL)ETHANON C8H9NO 135.16 CC(=O)c(cc1)ccc1N 93-61-8 N-METHYL-N-PHENYLFORMAMID C8H9NO 135.16 CN(c1ccccc1)C=O 103-81-1 BENZOLACETAMID C8H9NO 135.16 O=C(Cc1ccccc1)N 2498-50-2 4-aminobenzamidine C7H9N3 135.17 Nc1ccc(cc1)C(=N)N 95-16-9 BENZOTHIAZOL C7H5NS 135.19 c(ccc1sc2)cc1n2 272-16-2 1,2-benzisothiazole C7H5NS 135.19 c(ccc1sn2)cc1c2 271-06-7 6-azathianaphthene C7H5NS 135.19 c(ncc1sc2)cc1c2 103-72-0 ISOTHIOCYANATOBENZOL C7H5NS 135.19 S=C=Nc1ccccc1 622-80-0 N-PROPYLBENZOLAMIN C9H13N 135.21 CCCNc1ccccc1 622-57-1 N-ETHYL-4-METHYLBENZOLAMIN C9H13N 135.21 CCNc(cc1)ccc1C 102-27-2 n-ethyl-3-methylbenzenamine C9H13N 135.21 CCNc(ccc1)cc1C 768-52-5 n-(1-methylethyl)-benzenamine C9H13N 135.21 CC(C)Nc1ccccc1 94-68-8 N-ETHYL-2-METHYLBENZOLAMIN C9H13N 135.21 CCNc1ccccc1C 103-83-3 N,N-DIMETHYLBENZYLAMIN C9H13N 135.21 CN(C)Cc1ccccc1 643-28-7 2-ISOPROYPYLANILIN C9H13N 135.21 CC(C)c1ccccc1N 88-05-1 2,4,6-TRIMETHYLBENZOLAMIN C9H13N 135.21 Cc(cc1C)cc(C)c1N

Page 54 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 137-17-7 2,4,5-TRIMETHYLANILIN C9H13N 135.21 Nc1cc(C)c(C)cc1C 2696-84-6 4-N-PROPYLANILIN C9H13N 135.21 CCCc(cc1)ccc1N 99-88-7 4-(1-METHYLETHYL)BENZOLAMIN C9H13N 135.21 CC(C)c(cc1)ccc1N 6304-24-1 2-(2-methylpropyl)pyridine C9H13N 135.21 CC(C)Cc1ccccn1 14159-61-6 3-(2-methylpropyl)pyridine C9H13N 135.21 CC(C)Cc1cccnc1 3978-81-2 4-(1,1-DIMETHYLETHYL)PYRIDIN C9H13N 135.21 CC(C)(C)c1ccncc1 589-08-2 N-METHYLBENZOLETHANAMIN C9H13N 135.21 CNCCc1ccccc1 51-64-9 dextroamphetamine C9H13N 135.21 NC(C)Cc1ccccc1 156-34-3 a-methylbenzeneethanamine C9H13N 135.21 NC(C)Cc1ccccc1 2038-57-5 3-AMINOPROPYLBENZOL C9H13N 135.21 NCCCc1ccccc1 3261-62-9 4-methylbenzeneethanamine C9H13N 135.21 NCCc(cc1)ccc1C 541-53-7 thioimidodicarbonicdiamide C2H5N3S2 135.21 NC(=S)NC(N)=S 121-72-2 DIMETHYLAMINO-3-TOLUOL-(N,N-DIMETHYL-M-TOLUIDIN) C9H13N 135.21 CN(C)c(ccc1)cc1C 99-97-8 4-METHYL-N,N-DIMETHYLANILIN C9H13N 135.21 CN(C)c(cc1)ccc1C 613-97-8 N-ETHYL-N-METHYLBENZOLAMIN C9H13N 135.21 CCN(C)c1ccccc1 609-72-3 2-METHYL-N,N-DIMETHYLANILIN C9H13N 135.21 CN(C)c1ccccc1C 10025-78-2 TRICHLORSILAN HCl3Si 135.45 Cl[SiH](Cl)Cl 88-10-8 DIETHYLCARBAMINSAEURECHLORID C5H10ClNO 135.59 CCN(CC)C(Cl)=O 3822-68-2 DIFLUORMETHOXYTRIFLUORMETHAN C2HF5O 136.02 FC(F)OC(F)(F)F 480-96-6 BENZOFURAZAN-1-OXID C6H4N2O2 136.11 O=n2c1ccccc1no2 315-30-0 1,5-dihydro-4h-pyrazolo(3,4-d)pyrimidin-4-one C5H4N4O 136.11 O=C2NC=Nc1[nH]ncc21 68-94-0 HYPOXANTHIN_[SARKIN] C5H4N4O 136.11 O=C2NC=Nc1nc[nH]c21 1123-54-2 8-azaadenine C4H4N6 136.12 Nc2c1nn[nH]c1ncn2 613-84-3 2-HYDROXY-5-METHYLBENZALDEHYD C8H8O2 136.15 Cc(ccc1O)cc1C=O 698-27-1 2-HYDROXY-4-METHYLBENZALDEHYD C8H8O2 136.15 Cc(ccc1C=O)cc1O 118-93-4 1-(2-HYDROXYPHENYL)ETHANON C8H8O2 136.15 CC(=O)c1ccccc1O 93-58-3 BENZOESAEUREMETHYLESTER C8H8O2 136.15 COC(=O)c1ccccc1 104-57-4 AMEISENSAEUREPHENYLMETHYLESTER C8H8O2 136.15 O=COCc1ccccc1 122-79-2 ESSIGSAEUREPHENYLESTER C8H8O2 136.15 CC(=O)Oc1ccccc1 99-94-5 4-METHYLBENZOESAEURE C8H8O2 136.15 OC(=O)c(cc1)ccc1C 118-90-1 2-METHYLBENZOESAEURE C8H8O2 136.15 OC(=O)c1ccccc1C 99-04-7 3-METHYLBENZOESAEURE C8H8O2 136.15 OC(=O)c(ccc1)cc1C 526-86-3 2,3-dimethyl-2,5-cyclohexadiene-1,4-dione C8H8O2 136.15 CC1=C(C)C(=O)C=CC1=O 99-93-4 1-(4-HYDROXYPHENYL)ETHANON C8H8O2 136.15 CC(=O)c(cc1)ccc1O 591-31-1 3-METHOXYBENZALDEHYDE C8H8O2 136.15 COc1cc(C=O)ccc1 121-71-1 1-(3-HYDROXYPHENYL)ETHANON C8H8O2 136.15 CC(=O)c(ccc1)cc1O 137-18-8 2,5-DIMETHYLBENZOCHINON C8H8O2 136.15 CC1=CC(=O)C(C)=CC1=O 614-00-6 N-METHYL-N-NITROSOBENZOLAMIN C7H8N2O 136.15 CN(c1ccccc1)N=O 527-61-7 2,6-dimethyl-2,5-cyclohexadiene-1,4-dione C8H8O2 136.15 CC1=CC(=O)C=C(C)C1=O 103-82-2 BENZOLESSIGSAEURE C8H8O2 136.15 OC(=O)Cc1ccccc1 135-02-4 2-METHOXYBENZALDEHYD C8H8O2 136.15 COc1ccccc1C=O 123-11-5 4-METHOXYBENZALDEHYD C8H8O2 136.15 COc1ccc(C=O)cc1 23787-80-6 1-(3-methylpyrazin-2-yl)ethanone C7H8N2O 136.15 CC(=O)c1nccnc1C 582-24-1 2-hydroxy-1-phenylethanone C8H8O2 136.15 OCC(=O)c1ccccc1 623-15-4 4-(2-FURANYL)-3-BUTEN-2-ON C8H8O2 136.15 CC(=O)C=Cc1occc1 67860-38-2 1-(2-methylpyrimidin-4-yl)ethanone C7H8N2O 136.15 CC(=O)c(ccn1)nc1C 88-68-6 2-aminobenzamide C7H8N2O 136.15 Nc1ccccc1C(=O)N 114-33-0 n-methylnicotinamide C7H8N2O 136.15 CNC(c1cccnc1)=O 613-94-5 benzoylhydrazine C7H8N2O 136.15 NNC(c1ccccc1)=O 64-10-8 PHENYLHARNSTOFF C7H8N2O 136.15 O=C(N)Nc1ccccc1 115-77-5 PENTAERYTHRIT C5H12O4 136.15 OCC(CO)(CO)CO 3544-24-9 3-aminobenzamide C7H8N2O 136.15 Nc1cc(ccc1)C(=O)N 2835-68-9 4-AMINOBENZAMID C7H8N2O 136.15 Nc1ccc(cc1)C(=O)N 273-13-2 2,1,3-BENZOTHIADIAZOL C6H4N2S 136.18 c(ccc1ns2)cc1n2 93-54-9 ALPHA-ETHYLBENZOLMETHANOL C9H12O 136.19 CCC(O)c1ccccc1 1004-66-6 2-METHOXY-1,3-DIMETHYLBENZOL C9H12O 136.19 COc1c(C)cccc1C 536-50-5 p,alpha-dimethylbenzylalcohol C9H12O 136.19 OC(C)c(cc1)ccc1C 617-94-7 ALPHA,ALPHA-DIMETHYLBENZOLMETHANOL C9H12O 136.19 OC(C)(C)c1ccccc1 768-59-2 4-ethylbenzylalcohol C9H12O 136.19 OCc1ccc(CC)cc1 527-60-6 2,4,6-TRIMETHYLPHENOL C9H12O 136.19 Cc(cc1C)cc(C)c1O 122-97-4 BENZOLPROPANOL C9H12O 136.19 OCCCc1ccccc1 3558-60-9 1-PHENYL-2-METHOXYETHAN C9H12O 136.19 COCCc1ccccc1

Page 55 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 1123-85-9 BETA-METHYLBENZOLETHANOL C9H12O 136.19 OCC(C)c1ccccc1 699-02-5 4-methylbenzeneethanol C9H12O 136.19 OCCc(cc1)ccc1C 539-30-0 ETHYLBENZYLETHER C9H12O 136.19 CCOCc1ccccc1 698-87-3 ALPHA-METHYLBENZOLETHANOL C9H12O 136.19 OC(C)Cc1ccccc1 2416-94-6 2,3,6-TRIMETHYLPHENOL C9H12O 136.19 Cc1ccc(C)c(C)c1O 496-78-6 2,4,5-TRIMETHYLPHENOL C9H12O 136.19 Oc1cc(C)c(C)cc1C 697-82-5 2,3,5-TRIMETHYLPHENOL C9H12O 136.19 Cc(cc1O)cc(C)c1C 88-69-7 2-(1-METHYLETHYL)PHENOL C9H12O 136.19 CC(C)c1ccccc1O 698-71-5 3-ETHYL-5-METHYLPHENOL C9H12O 136.19 CCc(cc1O)cc(C)c1 526-85-2 2,3,4-TRIMETHYLPHENOL C9H12O 136.19 Oc1ccc(C)c(C)c1C 645-56-7 4-PROPYLPHENOL C9H12O 136.19 CCCc(cc1)ccc1O 99-89-8 4-ISOPROPYLPHENOL C9H12O 136.19 CC(C)c(cc1)ccc1O 618-45-1 3-(1-METHYLETHYL)PHENOL C9H12O 136.19 CC(C)c(ccc1)cc1O 644-35-9 2-PROPYLPHENOL C9H12O 136.19 CCCc1ccccc1O 1515-95-3 4-ETHYLMETHOXYBENZOL C9H12O 136.19 COc1ccc(CC)cc1 622-60-6 1-ETHOXY-4-METHYLBENZOL C9H12O 136.19 CCOc(cc1)ccc1C 621-32-9 1-ethoxy-3-methylbenzene C9H12O 136.19 CCOc(ccc1)cc1C 622-85-5 PROPOXYBENZOL C9H12O 136.19 CCCOc1ccccc1 6738-23-4 1-METHOXY-2,4-DIMETHYLBENZOL C9H12O 136.19 COc1ccc(C)cc1C 614-71-1 1-ETHOXY-2-METHYLBENZOL C9H12O 136.19 CCOc1ccccc1C 2836-03-5 N,N-DIMETHYL-1,2-BENZOLDIAMIN C8H12N2 136.20 CN(C)c1ccccc1N 644-21-3 1-ethyl-1-phenylhydrazine C8H12N2 136.20 CCN(N)c1ccccc1 2836-04-6 N,N-DIMETHYL-1,3-BENZOLDIAMIN C8H12N2 136.20 CN(C)c(ccc1)cc1N 15707-24-1 pyrazine, 2,3-diethyl- C8H12N2 136.20 CCc1nccnc1CC 99-98-9 N,N-DIMETHYL-1,4-BENZOLDIAMIN C8H12N2 136.20 CN(C)c(cc1)ccc1N 13925-05-8 2-methyl-5-propan-2-ylpyrazine C8H12N2 136.20 CC(C)c(nc1)cnc1C 13925-07-0 2-ethyl-3,5-dimethylpyrazine C8H12N2 136.20 CCc1ncc(C)nc1C 15707-34-3 5-ethyl-2,3-dimethylpyrazine C8H12N2 136.20 CCc(cnc1C)nc1C 3333-52-6 TETRAMETHYLBERNSTEINSAEUREDINITRIL C8H12N2 136.20 CC(C)(C(C)(C)C#N)C#N 629-40-3 1,8-OCTANDISAEUREDINITRIL C8H12N2 136.20 N#CCCCCCCC#N 1124-11-4 TETRAMETHYLPYRAZIN C8H12N2 136.20 Cc1nc(C)c(C)nc1C 1477-55-0 1,3-XYLYLENDIAMIN C8H12N2 136.20 NCc1cc(CN)ccc1 14094-12-3 2-METHYL-2-(METHYLSULFONYL)PROPAN C5H12O2S 136.21 CC(C)(C)S(C)(=O)=O 1185-55-3 TRIMETHOXYMETHYLSILAN C4H12O3Si 136.22 CO[Si](C)(OC)OC 4565-32-6 2,3-DIHYDROBENZO(B)THIOPHEN C8H8S 136.22 C2Sc1ccccc1C2 123-35-3 7-METHYL-3-METHYLEN-1,6-OCTADIEN C10H16 136.23 CC(C)=CCCC(=C)C=C 555-10-2 1-METHYLEN-4-ISOPROPYL-2-CYCLOHEXEN C10H16 136.23 CC(C)C1C=CC(CC1)=C 138-86-3 1-METHYL-4(1-METHYLETHENYL)CYCLOHEXEN C10H16 136.23 CC(C1CC=C(C)CC1)=C 99-86-5 1-METHYL-4(1-METHYLETHYL)-1,3-CYCLOHEXADIEN C10H16 136.23 CC(C)C(CC1)=CC=C1C 586-62-9 1-METHYL-4-(1-METHYLETHYLIDEN)CYCLOHEXEN C10H16 136.23 CC1=CCC(CC1)=C(C)C 99-83-2 1-METHYL-4-ISOPROPYL-1,3-CYCLOHEXADIEN C10H16 136.23 CC(C)C1C=CC(C)=CC1 99-85-4 1-METHYL-4-ISOPROPYL-1,4-CYCLOHEXADIEN C10H16 136.23 CC(C)C(CC=C1C)=CC1 127-91-3 3-PINEN C10H16 136.23 CC1(C)C2CC1CCC2=C 79-92-5 2,2-DIMETHYL-3-METHYLENBICYCLO(2.2.1)HEPTAN C10H16 136.23 CC2(C)C1CC(CC1)C2=C 554-61-0 2-carene C10H16 136.23 CC1(C)C2C=C(C)CCC21 13466-78-9 DELTA-3-CAREN C10H16 136.23 CC1(C)C2CC(C)=CCC21 80-56-8 2,6,6-TRIMETHYLBICYCLO(3.1.1)HEPT-2-EN C10H16 136.23 CC1(C)C2C=CC(C)C1C2 2437-95-8 dl-pin-2(3)-ene C10H16 136.23 CC1(C)C2CC1CC=C2C 508-32-7 1,7,7-TRIMETHYLTRICYCLO(2.2.1.0(2,6))HEPTAN C10H16 136.23 CC3(C)C2CC(C1C2)C31C 6004-38-2 TETRAHYDRODICYCLOPENTADIEN C10H16 136.23 C(CC1C3CC2)CC1C2C3 17760-91-7 DECAHYDROCYCLOPENTA(CD)PENTALEN C10H16 136.23 C(CC3C1C2CC3)C1CC2 53130-19-1 protoadamantane C10H16 136.23 C2CC1CC3CC1CC2C3 281-23-2 TRICYCLO(3.3.1.1(3,7))DECAN C10H16 136.23 C1C2CC(CC3C2)CC1C3 822-38-8 1,3-DITHIOLAN-2-THION C3H4S3 136.26 S=C1SCCS1 766-77-8 DIMETHYLPHENYLSILAN C8H12Si 136.27 C[SiH](C)c1ccccc1 1112-55-6 TETRAETHENYLSILAN C8H12Si 136.27 C=C[Si](C=C)(C=C)C=C 30453-31-7 ETHYLPROPYLDISULFID C5H12S2 136.28 CCCSSCC 2837-89-0 1-CHLORTETRAFLUORETHAN C2HClF4 136.48 FC(Cl)C(F)(F)F 354-25-6 1-CHLOR-1,1,2,2-TETRAFLUORETHAN C2HClF4 136.48 FC(F)C(F)(F)Cl 535-13-7 2-CHLORPROPANSAEUREETHYLESTER C5H9ClO2 136.58 CCOC(C(C)Cl)=O 105-48-6 CHLORESSIGSAEURE-1-METHYLETHYLESTER C5H9ClO2 136.58 CC(C)OC(CCl)=O 623-71-2 3-CHLORPROPANSAEUREETHYLESTER C5H9ClO2 136.58 CCOC(CCCl)=O

Page 56 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 3153-37-5 METHYL-4-CHLORBUTYRAT C5H9ClO2 136.58 ClCCCC(OC)=O 1119-46-6 5-CHLORPENTANSAEURE C5H9ClO2 136.58 ClCCCCC(O)=O 628-09-1 3-chloro-1-propanolacetate C5H9ClO2 136.58 ClCCCOC(C)=O 592-34-7 carbonochloridicacidbutylester C5H9ClO2 136.58 CCCCOC(Cl)=O 543-27-1 CHLORAMEISENSAEUREISOBUTYLESTER C5H9ClO2 136.58 CC(C)COC(Cl)=O 598-31-2 1-BROM-2-PROPANON C3H5BrO 136.98 BrCC(C)=O 507-19-7 2-BROM-2-METHYLPROPAN C4H9Br 137.02 CC(C)(C)Br 78-76-2 2-BROMBUTAN C4H9Br 137.02 CCC(C)Br 109-65-9 1-BUTYLBROMID C4H9Br 137.02 CCCCBr 78-77-3 1-BROM-2-METHYLPROPAN C4H9Br 137.02 BrCC(C)C 624-43-1 glycerol-1-nitrate C3H7NO5 137.09 OCC(O)CON(=O)=O 620-12-2 glycerol-beta-nitrate C3H7NO5 137.09 OCC(CO)ON(=O)=O 99-08-1 3-NITROTOLUOL C7H7NO2 137.14 Cc1cc(ccc1)N(=O)=O 88-72-2 2-NITROTOLUOL C7H7NO2 137.14 Cc1ccccc1N(=O)=O 99-99-0 4-NITROTOLUOL C7H7NO2 137.14 Cc1ccc(cc1)N(=O)=O 622-42-4 (NITROMETHYL)BENZOL C7H7NO2 137.14 O=N(Cc1ccccc1)=O 501-81-5 3-pyridineaceticacid C7H7NO2 137.14 OC(=O)Cc1cccnc1 495-18-1 benzohydroxamicacid C7H7NO2 137.14 ONC(c1ccccc1)=O 65-45-2 O-HYDROXYBENZAMID C7H7NO2 137.14 Oc1ccccc1C(=O)N 94-67-7 2-HYDROXYBENZALDEHYDOXIM C7H7NO2 137.14 ON=Cc1ccccc1O 622-46-8 CARBAMIDSAEUREPHENYLESTER C7H7NO2 137.14 O=C(Oc1ccccc1)N 93-60-7 3-PYRIDINCARBONSAEUREMETHYLESTER C7H7NO2 137.14 COC(=O)c1cccnc1 118-92-3 2-AMINOBENZOESAEURE C7H7NO2 137.14 OC(=O)c1ccccc1N 2459-09-8 4-CARBOMETHOXYPYRIDIN C7H7NO2 137.14 COC(=O)c1ccncc1 99-05-8 3-AMINOBENZOESAEURE C7H7NO2 137.14 OC(=O)c(ccc1)cc1N 150-13-0 4-AMINOBENZOESAEURE C7H7NO2 137.14 OC(=O)c(cc1)ccc1N 54-85-3 4-PYRIDINCARBONSAEUREHYDRAZID C6H7N3O 137.14 NNC(c1ccncc1)=O 619-57-8 4-HYDROXYBENZAMID C7H7NO2 137.14 Oc1ccc(cc1)C(=O)N 51-67-2 2-(P-HYDROXYPHENYL)-ETHYLAMIN C8H11NO 137.18 NCCc(cc1)ccc1O 122-98-5 N-(2-HYDROXYETHYL)-ANILIN C8H11NO 137.18 OCCNc1ccccc1 94-70-2 2-PHENETIDIN C8H11NO 137.18 CCOc1ccccc1N 120-71-8 2-METHOXY-5-METHYLBENZOLAMIN C8H11NO 137.18 COc1ccc(C)cc1N 102-50-1 4-methoxy-2-methylbenzenamine C8H11NO 137.18 COc(ccc1N)cc1C 156-43-4 4-ETHOXYBENZOLAMIN C8H11NO 137.18 CCOc(cc1)ccc1N 39741-41-8 1-(1-ethylpyrrol-2-yl)ethanone C8H11NO 137.18 CCn1cccc1C(C)=O 99-07-0 3-DIMETHYLAMINO-PHENOL C8H11NO 137.18 CN(C)c(ccc1)cc1O 621-31-8 3-ETHYLAMINOPHENOL C8H11NO 137.18 CCNc(ccc1)cc1O 2859-67-8 3-PYRIDINPROPANOL C8H11NO 137.18 OCCCc1cccnc1 104-10-9 4-AMINOBENZOLETHANOL C8H11NO 137.18 OCCc(cc1)ccc1N 2629-72-3 4-PYRIDINPROPANOL C8H11NO 137.18 OCCCc1ccncc1 2859-68-9 2-PYRIDINPROPANOL C8H11NO 137.18 OCCCc1ccccn1 114-91-0 2-(2-methoxyethyl)pyridine C8H11NO 137.18 COCCc1ccccn1 2393-23-9 4-METHOXYBENZYLAMIN C8H11NO 137.18 COc1ccc(CN)cc1 2227-79-4 BENZOLCARBOTHIOAMID C7H7NS 137.20 NC(c1ccccc1)=S 102-70-5 N,N-DI-2-PROPENYL-2-PROPEN-1-AMIN C9H15N 137.22 C=CCN(CC=C)CC=C 7719-12-2 PHOSPHORTRICHLORID Cl3P 137.33 ClP(Cl)Cl 75-69-4 TRICHLORFLUORMETHAN CCl3F 137.37 FC(Cl)(Cl)Cl 873-32-5 2-CHLORBENZONITRIL C7H4ClN 137.57 Clc1ccccc1C#N 766-84-7 3-chlorobenzonitrile C7H4ClN 137.57 Clc1cc(C#N)ccc1 623-03-0 4-CHLORBENZONITRIL C7H4ClN 137.57 Clc1ccc(C#N)cc1 79-15-2 n-bromoacetamide C2H4BrNO 137.96 BrNC(C)=O 683-57-8 bromoacetamide C2H4BrNO 137.96 BrCC(=O)N 75-60-5 dimethylarsinicacid C2H7AsO2 138.00 O[As](C)(C)=O 76-16-4 HEXAFLUORETHAN C2F6 138.01 FC(F)(F)C(F)(F)F 762-04-9 DIETHYLPHOSPHIT C4H11O3P 138.10 CCO[PH](OCC)=O 539-47-9 3-(2-FURANYL)-2-PROPENSAEURE C7H6O3 138.12 OC(=O)C=Cc1occc1 88-74-4 2-NITROBENZOLAMIN C6H6N2O2 138.12 Nc1ccccc1N(=O)=O 99-09-2 3-NITROBENZOLAMIN C6H6N2O2 138.12 Nc1cc(ccc1)N(=O)=O 645-55-6 n-nitrobenzenamine C6H6N2O2 138.12 O=N(=O)Nc1ccccc1 95-01-2 2,4-dihydroxybenzaldehyde C7H6O3 138.12 Oc(ccc1C=O)cc1O 933-90-4 3-hydroxy-2-pyridinecarboxamide C6H6N2O2 138.12 Oc1cccnc1C(=O)N 139-85-5 3,4-DIHYDROXYBENZALDEHYD C7H6O3 138.12 Oc1ccc(C=O)cc1O

Page 57 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 93-59-4 perbenzoicacid C7H6O3 138.12 OC(=O)Oc1ccccc1 69-72-7 2-HYDROXYBENZOESAEURE C7H6O3 138.12 OC(=O)c1ccccc1O 99-96-7 4-HYDROXYBENZOESAEURE C7H6O3 138.12 OC(=O)c(cc1)ccc1O 99-06-9 HYDROXY-3-BENZOESAEURE C7H6O3 138.12 OC(=O)c(ccc1)cc1O 105-11-3 2,5-cyclohexadiene-1,4-dione-dioxime C6H6N2O2 138.12 ON=C1C=CC(=NO)C=C1 100-01-6 4-NITROBENZOLAMIN C6H6N2O2 138.12 Nc1ccc(cc1)N(=O)=O 3167-49-5 6-amino-3-pyridinecarboxylicacid C6H6N2O2 138.12 OC(=O)c(cn1)ccc1N 104-98-3 3-(1h-imidazol-4-yl)-2-propenoicacid C6H6N2O2 138.12 OC(=O)C=Cc1c[nH]cn1 403-42-9 1-(4-FLUORPHENYL)ETHANON C8H7FO 138.14 CC(=O)c(cc1)ccc1F 151-10-0 1,3-DIMETHOXYBENZOL C8H10O2 138.16 COc1cc(OC)ccc1 150-78-7 1,4-DIMETHOXYBENZOL C8H10O2 138.16 COc1ccc(OC)cc1 94-71-3 2-ETHOXYPHENOL C8H10O2 138.16 CCOc1ccccc1O 93-51-6 2-METHOXY-4-METHYLPHENOL C8H10O2 138.16 COc1cc(C)ccc1O 93-56-1 1-PHENYL-1,2-ETHANDIOL C8H10O2 138.16 OCC(O)c1ccccc1 501-94-0 4-HYDROXYBENZOLETHANOL C8H10O2 138.16 OCCc(cc1)ccc1O 3071-32-7 HYDROPEROXIDE,1-PHENYLETHYL C8H10O2 138.16 OOC(C)c1ccccc1 626-18-6 1,3-benzenedimethanol C8H10O2 138.16 OCc1cc(CO)ccc1 105-13-5 4-METHOXYBENZOLMETHANOL C8H10O2 138.16 COc1ccc(CO)cc1 122-99-6 ETHYLENGLYKOLMONOPHENYLETHER C8H10O2 138.16 OCCOc1ccccc1 91-16-7 1,2-DIMETHOXYBENZOL C8H10O2 138.16 COc1ccccc1OC 4208-57-5 1-furan-2-ylbutan-1-one C8H10O2 138.16 CCCC(=O)c1occc1 589-29-7 1,4-BENZOLDIMETHANOL C8H10O2 138.16 OCc1ccc(CO)cc1 622-62-8 4-ETHOXYPHENOL C8H10O2 138.16 CCOc(cc1)ccc1O 612-16-8 2-METHOXYBENZOLMETHANOL C8H10O2 138.16 COc1ccccc1CO 699-17-2 4-(2-furanyl)-2-butanone C8H10O2 138.16 CC(CCc1occc1)=O 621-34-1 3-ETHOXYPHENOL C8H10O2 138.16 CCOc(ccc1)cc1O 10599-70-9 1-(2,5-dimethylfuran-3-yl)ethanone C8H10O2 138.16 CC(=O)c1cc(C)oc1C 22940-86-9 1-(3,5-dimethylfuran-2-yl)ethanone C8H10O2 138.16 CC(=O)c1oc(C)cc1C 615-90-7 2,5-DIMETHYL-1,4-BENZOLDIOL C8H10O2 138.16 Oc1cc(C)c(O)cc1C 608-43-5 2,3-dimethyl-1,4-benzenediol C8H10O2 138.16 Oc1ccc(O)c(C)c1C 615-89-4 4,6-DIMETHYL-1,3-BENZOLDIOL C8H10O2 138.16 Oc1cc(O)c(C)cc1C 527-55-9 1,3-DIHYDROXY-4,5-DIMETHYLBENZOL C8H10O2 138.16 Oc(cc1O)cc(C)c1C 488-87-9 1,3-DIHYDROXY-2,5-DIMETHYLBENZOL C8H10O2 138.16 Cc(cc1O)cc(O)c1C 2896-60-8 2,4-DIXYDROXY-1-ETHYLBENZEN C8H10O2 138.16 CCc1ccc(O)cc1O 25680-58-4 3-ethyl-2-methoxypyrazine C7H10N2O 138.17 COc1nccnc1CC 615-05-4 2,4diaminoanisole C7H10N2O 138.17 COc1ccc(N)cc1N 54-95-5 pentylenetetrazole C6H10N4 138.17 C2CCn1nnnc1CC2 98-91-9 benzenecarbothioicacid C7H6OS 138.19 SC(=O)c1ccccc1 623-81-4 DIETHYLSULFIT C4H10O3S 138.19 CCOS(OCC)=O 513-12-2 2-(ethylsulfonyl)ethanol C4H10O3S 138.19 OCCS(CC)(=O)=O 504-20-1 2,6-DIMETHYL-2,5-HEPTADIEN-4-ON C9H14O 138.21 CC(C)=CC(=O)C=C(C)C 3088-41-3 3-PIPERIDINOPROPIONITRIL C8H14N2 138.21 N#CCCN1CCCCC1 78-59-1 3,5,5-TRIMETHYL-2-CYCLOHEXEN-1-ON C9H14O 138.21 CC1(C)CC(=O)C=C(C)C1 49570-30-1 1,4-DIMETHYL-2,3-DIAZABICYCLO[2.2.2]OCT-2-EN C8H14N2 138.21 CC2(CC1)CCC1(C)N=N2 3777-69-3 2-pentylfuran C9H14O 138.21 CCCCCc1occc1 4410-99-5 2-phenylethanethiol C8H10S 138.23 SCCc1ccccc1 766-92-7 1-PHENYL-2-THIAPROPAN C8H10S 138.23 CSCc1ccccc1 622-38-8 (ETHYLTHIO)BENZOL C8H10S 138.23 CCSc1ccccc1 2150-02-9 BIS-(2-MERCAPTOETHYL)-ETHER C4H10OS2 138.25 SCCOCCS 764-93-2 1-DECIN C10H18 138.25 CCCCCCCCC#C 2384-85-2 3-DECIN C10H18 138.25 CCCCCCC#CCC 1942-46-7 5-DECIN C10H18 138.25 CCCCC#CCCCC 1647-16-1 1,9-DECADIEN C10H18 138.25 C=CCCCCCCC=C 1124-27-2 1-METHYL-4-(1-METHYLETHYLIDENE)CYCLOHEXANE C10H18 138.25 CC1CCC(CC1)=C(C)C 4291-98-9 1-PENTYLCYCLOPENTEN C10H18 138.25 CCCCCC1=CCCC1 473-55-2 2,6,6-TRIMETHYLBICYCLO[3.1.1]HEPTAN C10H18 138.25 CC2CCC1CC2C1(C)C 493-01-6 CIS-DECALIN C10H18 138.25 C(CCC1CC2)CC1CC2 493-02-7 TRANS-DECALIN C10H18 138.25 C(CCC1CC2)CC1CC2 291-21-4 1,3,5-TRITHIAN C3H6S3 138.28 S1CSCSC1 1073-67-2 1-CHLOR-4-ETHENYLBENZOL C8H7Cl 138.60 Clc1ccc(C=C)cc1 618-34-8 (1-CHLOROETHENYL)-BENZENE C8H7Cl 138.60 ClC(=C)c1ccccc1 2039-87-4 1-CHLOR-2-ETHENYLBENZOL C8H7Cl 138.60 Clc1ccccc1C=C

Page 58 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 79-08-3 BROMESSIGSAEURE C2H3BrO2 138.95 BrCC(O)=O 627-18-9 3-BROM-1-PROPANOL C3H7BrO 138.99 OCCCBr 50642-23-4 sarin C4H9FO2P 139.08 CC(C)OP(F)(C)=O 1897-52-5 2,6-difluorobenzonitrile C7H3F2N 139.10 Fc1cccc(F)c1C#N 88-75-5 O-NITROPHENOL C6H5NO3 139.11 Oc1ccccc1N(=O)=O 100-02-7 4-NITROPHENOL C6H5NO3 139.11 Oc1ccc(cc1)N(=O)=O 554-84-7 3-NITROPHENOL C6H5NO3 139.11 Oc1cc(ccc1)N(=O)=O 2398-81-4 oxiniacicacid C6H5NO3 139.11 OC(=O)c1cn(ccc1)=O 4214-76-0 5-NITRO-2-PYRIDINAMIN C5H5N3O2 139.11 Nc1ccc(cn1)N(=O)=O 459-23-4 p-fluorobenzaldoxime C7H6FNO 139.13 ON=Cc(cc1)ccc1F 445-28-3 2-fluorobenzamide C7H6FNO 139.13 Fc1ccccc1C(=O)N 824-75-9 4-FLUORBENZAMID C7H6FNO 139.13 Fc1ccc(cc1)C(=O)N 73-67-6 toxopyrimidine C6H9N3O 139.16 OCc1cnc(C)nc1N 107-68-6 2-(ethylamino)-ethanesulfonicacid C3H9NO3S 139.17 C[NH2+]CCS([O-])(=O)=O 1122-83-4 n-sulfinylbenzenamine C6H5NOS 139.18 O=S=Nc1ccccc1 53833-32-2 4,5-dimethyl-2-propyl-1,3-oxazole C8H13NO 139.20 CCCc(nc1C)oc1C 2987-53-3 2-(METHYLTHIO)BENZOLAMIN C7H9NS 139.22 CSc1ccccc1N 65505-18-2 5-ethenyl-2,4-dimethyl-1,3-thiazole C7H9NS 139.22 Cc(nc1C)sc1C=C 104-96-1 4-(METHYLTHIO)BENZOLAMIN C7H9NS 139.22 CSc(cc1)ccc1N 2243-27-8 NONANNITRIL C9H17N 139.24 CCCCCCCCC#N 767-92-0 TRANS-DECAHYDROCHINOLIN C9H17N 139.24 C2NC1CCCCC1CC2 563-70-2 BROMNITROMETHAN CH2BrNO2 139.94 BrCN(=O)=O 768-39-8 DIFLUOR(4-METHYLPHENYL)BORAN C7H7BF2 139.94 FB(F)c(cc1)ccc1C 124-58-3 methylarsonicacid CH5AsO3 139.97 O[As](O)(C)=O 512-56-1 TRIMETHYLPHOSPHAT C3H9O4P 140.08 COP(OC)(OC)=O 500-05-0 2-oxo-2h-pyran-5-carboxylicacid C6H4O4 140.09 OC(=O)C(=CO1)C=CC1=O 1124-33-0 4-nitropyridine-1-oxide C5H4N2O3 140.10 O=N(=O)c1ccn(=O)cc1 456-22-4 4-FLUORBENZOESAEURE C7H5FO2 140.11 OC(=O)c(cc1)ccc1F 445-29-4 2-FLUORBENZOESAEURE C7H5FO2 140.11 OC(=O)c1ccccc1F 455-38-9 3-FLUORBENZOESAEURE C7H5FO2 140.11 OC(=O)c(ccc1)cc1F 123-43-3 sulfoaceticacid C2H4O5S 140.12 OC(=O)CS(O)(=O)=O 4538-37-8 1,4-DIISOCYANATOBUTAN C6H8N2O2 140.14 O=C=NCCCCN=C=O 2209-36-1 4,5,6,7-tetrahydrobenzofurazan-2-oxide C6H8N2O2 140.14 O=n2c1CCCCc1no2 614-99-3 2-FURANCARBONSAEUREETHYLESTER C7H8O3 140.14 CCOC(=O)c1occc1 623-17-6 2-FURANMETHANOLACETAT C7H8O3 140.14 CC(OCc1occc1)=O 824-46-4 2-methoxy-1,4-benzenediol C7H8O3 140.14 COc1cc(O)ccc1O 934-00-9 3-METHOXY-1,2-BENZOLDIOL C7H8O3 140.14 COc(cccc1O)c1O 874-14-6 1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINDION C6H8N2O2 140.14 Cn1ccc(=O)n(C)c1=O 4160-72-9 1,5-DIMETHYL-2,4(1H,3H)-PYRIMIDINDION C6H8N2O2 140.14 Cc1cn(C)c(=O)[nH]c1=O 451-80-9 1-ETHOXY-2-FLUORBENZOL C8H9FO 140.16 CCOc1ccccc1F 459-26-7 P-FLUOROPHENETOL C8H9FO 140.16 CCOc(cc1)ccc1F 458-03-7 1-ETHOXY-3-FLUORBENZOL C8H9FO 140.16 CCOc(ccc1)cc1F 933-52-8 2,2,4,4-TETRAMETHYL-1,3-CYCLOBUTANDION C8H12O2 140.18 CC1(C)C(C(C)(C)C1=O)=O 53263-58-4 5-ethyl-2-hydroxy-3-methylcyclopent-2-en-1-one C8H12O2 140.18 CCC1CC(C)=C(O)C1=O 42348-12-9 3-ethyl-2-hydroxy-4-methylcyclopent-2-en-1-one C8H12O2 140.18 CCC1=C(O)C(CC1C)=O 2396-84-1 2,4-hexadienoicacidethylester C8H12O2 140.18 CCOC(=O)C=CC=CC 3508-78-9 3-(2-propenyl)-2,4-pentanedione C8H12O2 140.18 CC(C(CC=C)C(C)=O)=O 562-46-9 4,4-dimethyl-1,3-cyclohexanedione C8H12O2 140.18 CC1(C)CCC(CC1=O)=O 106-87-6 3-OXIRANYL-7-OXABICYCLO(4.1.0)HEPTAN C8H12O2 140.18 C1OC1C3CC2OC2CC3 126-81-8 5,5-dimethyl-1,3-cyclohexanedione C8H12O2 140.18 CC1(C)CC(CC(C1)=O)=O 1801-72-5 diallylurea C7H12N2O 140.18 C=CCNC(=O)NCC=C 286-85-1 1H-CYCLOPROPA(B)NAPHTHALIN C11H8 140.18 C(c31)c1cc2ccccc2c3 100-97-0 1,3,5,7-TETRAAZATRICYCLO(3.3.1.1(3,7))DECAN C6H12N4 140.19 C1N2CN(CN3C2)CN1C3 1073-29-6 2-methylsulfanylphenol C7H8OS 140.20 CSc1ccccc1O 7217-59-6 2-methoxybenzenethiol C7H8OS 140.20 COc1ccccc1S 13679-74-8 1-(5-METHYL-2-THIENYL)ETHANON C7H8OS 140.20 CC(=O)c(cc1)sc1C 1193-82-4 methylphenylsulfoxide C7H8OS 140.20 CS(=O)c1ccccc1 35250-53-4 2-pyrazin-2-ylethanethiol C6H8N2S 140.21 SCCc1cnccn1 111-97-7 THIODIPROPIONITRIL C6H8N2S 140.21 N#CCCSCCC#N 2277-16-9 (e)-non-4-enal C9H16O 140.22 CCCCC=CCCC=O 106-72-9 2,6-dimethylhept-5-enal C9H16O 140.22 CC(CCC=C(C)C)C=O 2277-19-2 (z)-non-6-enal C9H16O 140.22 CCC=CCCCCC=O

Page 59 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 63759-55-7 3-methylideneoctan-2-one C9H16O 140.22 CCCCCC(=C)C(C)=O 2408-37-9 2,2,6-trimethylcyclohexanone C9H16O 140.22 CC(CCCC1(C)C)C1=O 1004-77-9 2-(1-methylethyl)cyclohexanone C9H16O 140.22 CC(C)C1CCCCC1=O 94-65-5 2-propylcyclohexanone C9H16O 140.22 CCCC1CCCCC1=O 2230-70-8 2,4,4-TRIMETHYLCYCLOHEXANON C9H16O 140.22 CC1(C)CC(C)C(CC1)=O 5009-32-5 non-8-en-2-one C9H16O 140.22 CC(CCCCCC=C)=O 873-94-9 3,5,5-TRIMETHYLCYCLOHEXANON C9H16O 140.22 CC(C1)CC(CC1(C)C)=O 3350-30-9 CYCLONONANON C9H16O 140.22 O=C1CCCCCCCC1 1455-20-5 2-BUTYLTHIOPHEN C8H12S 140.25 CCCCc1sccc1 55735-23-4 THIOPHENE,3-ETHYL-2,5-DIMETHYL- C8H12S 140.25 CCc1cc(C)sc1C 2980-71-4 2-METHYL-1-NONEN C10H20 140.27 CCCCCCCC(C)=C 26741-24-2 1-NONENE,8-METHYL- C10H20 140.27 CC(C)CCCCCC=C 20348-51-0 (2Z)-2-DECEN C10H20 140.27 CCCCCCCC=CC 872-05-9 1-DECEN C10H20 140.27 CCCCCCCCC=C 4057-42-5 2,6-dimethyl-2-octene C10H20 140.27 CCC(C)CCC=C(C)C 20063-97-2 (2E)-2-DECEN C10H20 140.27 CCCCCCCC=CC 1331-43-7 DIETHYLCYCLOHEXAN(ISOMERENGEMISCH) C10H20 140.27 CCC1(CC)CCCCC1 78-01-3 1,1-DIETHYLCYCLOHEXAN C10H20 140.27 CCC1(CC)CCCCC1 3178-22-1 (1,1-DIMETHYLETHYL)CYCLOHEXAN C10H20 140.27 CC(C)(C)C1CCCCC1 3726-45-2 CYCLOHEXANE,-1,2,3,4-TETRAMETHYL- C10H20 140.27 CC1CCC(C)C(C)C1C 7058-01-7 SEK.-BUTYLCYCLOHEXAN C10H20 140.27 CCC(C)C1CCCCC1 1678-98-4 (2-METHYLPROPYL)CYCLOHEXAN C10H20 140.27 CC(C)CC1CCCCC1 4291-80-9 1-methyl-3-propylcyclohexane C10H20 140.27 CCCC(CCC1)CC1C 13990-93-7 CYCLOHEXANE,TRANS-1,4-DIETHYL C10H20 140.27 CCC1CCC(CC)CC1 99-82-1 1-METHYL-4-(1-METHYLETHYL)CYCLOHEXAN C10H20 140.27 CC1CCC(C(C)C)CC1 4291-79-6 1-methyl-2-propylcyclohexane C10H20 140.27 CCCC1CCCCC1C 3741-00-2 PENTYLCYCLOPENTAN C10H20 140.27 CCCCCC1CCCC1 293-96-9 CYCLODECAN C10H20 140.27 C1CCCCCCCCC1 1678-93-9 BUTYLCYCLOHEXAN C10H20 140.27 CCCCC1CCCCC1 31499-71-5 methylsulfanyldisulfanylethane C3H8S3 140.29 CCSSSC 557-89-1 CHLORDIMETHYLARSIN C2H6AsCl 140.44 C[As](C)Cl 401-56-9 CHLORFLUORESSIGSAEUREETHYLESTER C4H6ClFO2 140.54 CCOC(C(F)Cl)=O 89-98-5 2-CHLORBENZALDEHYD C7H5ClO 140.57 Clc1ccccc1C=O 587-04-2 3-CHLORBENZALDEHYD C7H5ClO 140.57 Clc1cc(C=O)ccc1 104-88-1 4-CHLORBENZALDEHYD C7H5ClO 140.57 Clc1ccc(C=O)cc1 98-88-4 BENZOYLCHLORID C7H5ClO 140.57 ClC(=O)c1ccccc1 104-82-5 4-METHYLBENZYLCHLORID C8H9Cl 140.61 ClCc(cc1)ccc1C 620-19-9 1-(CHLORMETHYL)-3-METHYLBENZOL C8H9Cl 140.61 ClCc(ccc1)cc1C 622-24-2 2-PHENYLETHYLCHLORID C8H9Cl 140.61 ClCCc1ccccc1 552-45-4 1-(CHLORMETHYL)-2-METHYLBENZOL C8H9Cl 140.61 ClCc1ccccc1C 615-60-1 4-CHLORO-1,2-DIMETHYLBENZENE C8H9Cl 140.61 Clc(ccc1C)cc1C 608-23-1 1-CHLORO-2,3-DIMETHYLBENZENE C8H9Cl 140.61 Cc1cccc(Cl)c1C 622-98-0 1-CHLOR-4-ETHYLBENZOL C8H9Cl 140.61 CCc1ccc(Cl)cc1 620-16-6 1-CHLOR-3-ETHYLBENZOL C8H9Cl 140.61 CCc1cc(Cl)ccc1 89-96-3 1-CHLOR-2-ETHYLBENZOL C8H9Cl 140.61 CCc1ccccc1Cl 95-66-9 1-chloro-2,4-dimethylbenzene C8H9Cl 140.61 Cc(ccc1Cl)cc1C 95-72-7 2-chloro-1,4-dimethylbenzene C8H9Cl 140.61 Cc(ccc1C)cc1Cl 352-91-0 1-bromo-3-fluoropropane C3H6BrF 140.98 FCCCBr 628-76-2 1,5-DICHLORPENTAN C5H10Cl2 141.04 ClCCCCCCl 626-92-6 1,4-DICHLORPENTAN C5H10Cl2 141.04 ClCCCC(C)Cl 623-34-7 1,4-DICHLOR-2-METHYLBUTAN C5H10Cl2 141.04 ClCCC(C)CCl 624-96-4 1,3-DICHLOR-3-METHYLBUTAN C5H10Cl2 141.04 ClCCC(C)(C)Cl 625-67-2 2,4-DICHLORPENTAN C5H10Cl2 141.04 CC(Cl)CC(C)Cl 1674-33-5 1,2-DICHLORPENTAN C5H10Cl2 141.04 CCCC(Cl)CCl 600-11-3 2,3-DICHLORPENTAN C5H10Cl2 141.04 CCC(Cl)C(C)Cl 507-45-9 2,3-DICHLOR-2-METHYLBUTAN C5H10Cl2 141.04 CC(Cl)C(C)(C)Cl 625-66-1 1,1-DICHLOR-3-METHYLBUTAN C5H10Cl2 141.04 CC(C)CC(Cl)Cl 124-70-9 DICHLORETHENYLMETHYLSILAN C3H6Cl2Si 141.07 C[Si](Cl)(Cl)C=C 698-63-5 5-NITROFURFUROL C5H3NO4 141.08 O=Cc1oc(cc1)N(=O)=O 402-67-5 3-FLUORNITROBENZOL C6H4FNO2 141.10 Fc1cc(ccc1)N(=O)=O 1493-27-2 2-FLUORNITROBENZOL C6H4FNO2 141.10 Fc1ccccc1N(=O)=O 350-46-9 4-FLUORNITROBENZOL C6H4FNO2 141.10 Fc1ccc(cc1)N(=O)=O

Page 60 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 551-92-8 1,2-DIMETHYL-5-NITRO-1H-IMIDAZOL C5H7N3O2 141.13 Cc1ncc(n1C)N(=O)=O 499-04-7 1,2,5,6-tetrahydro-1-methylnicotinicacid C7H11NO2 141.17 CN1CC(=CCC1)C(O)=O 302-66-9 meparfynolcarbamate C7H11NO2 141.17 CCC(C)(C#C)OC(=O)N 77-67-8 ethosuximide C7H11NO2 141.17 CCC1(C)CC(=O)NC1=O 43039-98-1 1-(1,3-thiazol-2-yl)propan-1-one C6H7NOS 141.19 CCC(=O)c1sccn1 120-29-6 tropine C8H15NO 141.21 OC2CC(CCC1C2)N1C 935-30-8 2-azacyclo-nonanone C8H15NO 141.21 O=C1NCCCCCCC1 15679-13-7 4-methyl-2-propan-2-yl-1,3-thiazole C7H11NS 141.24 CC(C)c(sc1)nc1C 18277-27-5 2-butan-2-yl-1,3-thiazole C7H11NS 141.24 CCC(C)c1sccn1 18640-74-9 2-(2-methylpropyl)-1,3-thiazole C7H11NS 141.24 CC(C)Cc1sccn1 49776-81-0 6-isothiocyanatohex-1-ene C7H11NS 141.24 C=CCCCCN=C=S 1122-82-3 isothiocyanatocyclohexane C7H11NS 141.24 S=C=NC1CCCCC1 503-01-5 2-METHYL-6-METHYLAMINO-2-HEPTEN C9H19N 141.25 CNC(C)CCC=C(C)C 102-45-4 n,a-dimethylcyclopentaneethanamine C9H19N 141.25 CNCC(C)C1CCCC1 768-66-1 2,2,6,6-TETRAMETHYLPIPERIDIN C9H19N 141.25 CC1(C)NC(C)(C)CCC1 3018-09-5 1-bromo-2-chloroethene C2H2BrCl 141.39 ClC=CBr 1189-71-5 sulfurylchlorideisocyanate CClNO3S 141.53 ClS(=O)(=O)N=C=O 932-96-7 4-CHLOR-N-METHYLANILIN C7H8ClN 141.60 CNc1ccc(Cl)cc1 615-65-6 2-CHLOR-4-METHYLBENZOLAMIN C7H8ClN 141.60 Cc(ccc1N)cc1Cl 95-81-8 2-CHLOR-5-METHYLBENZOLAMIN C7H8ClN 141.60 Cc(ccc1Cl)cc1N 87-60-5 3-CHLOR-2-METHYLBENZOLAMIN C7H8ClN 141.60 Nc1cccc(Cl)c1C 95-69-2 2-methyl-4-chloroaniline C7H8ClN 141.60 Clc(ccc1N)cc1C 95-79-4 5-CHLOR-2-METHYLBENZOLAMIN C7H8ClN 141.60 Clc(ccc1C)cc1N 95-74-9 3-CHLORO-4-METHYLANILIN C7H8ClN 141.60 Nc(ccc1C)cc1Cl 74-88-4 METHYLIODID CH3I 141.94 CI 7778-39-4 arsenicacid H3AsO4 141.94 O[As](O)(O)=O 488-86-8 4,5-dihydroxy-4-cyclopentene-1,2,3-trione C5H2O5 142.07 OC1=C(O)C(=O)C(=O)C1=O 50-71-5 2,4,5,6(1H,3H)-PYRIMIDINTETRON C4H2N2O4 142.07 O=C(NC1=O)NC(=O)C1=O 383-63-1 TRIFLUORESSIGSAEUREETHYLESTER C4H5F3O2 142.08 CCOC(C(F)(F)F)=O 1779-48-2 BENZOLPHOSPHONIGSAEURE C6H7O2P 142.09 O[PH](=O)c1ccccc1 501-30-4 5-hydroxy-2-(hydroxymethyl)-4h-pyran-4-one C6H6O4 142.11 OCC(OC=C1O)=CC1=O 352-61-4 5,5,5-trifluoro-1-pentanol C5H9F3O 142.12 OCCCCC(F)(F)F 698-10-2 5-ethyl-3-hydroxy-4-methyl-5h-furan-2-one C7H10O3 142.15 CCC1OC(=O)C(O)=C1C 106-91-2 2-METHYL-2-PROPENSAEUREOXIRANYLMETHYLESTER C7H10O3 142.15 CC(=C)C(OCC1OC1)=O 1118-84-9 3-oxobutanoicacid-2-propenylester C7H10O3 142.15 CC(CC(OCC=C)=O)=O 626-53-9 2,4,6-heptanetrione C7H10O3 142.15 CC(CC(CC(C)=O)=O)=O 4077-47-8 4-methoxy-2,5-dimethylfuran-3-one C7H10O3 142.15 COC(=C(C)OC1C)C1=O 281-32-3 2,4,10-TRIOXATRICYCLO(3.3.1.1(3,7))DECAN C7H10O3 142.15 O2C1CC3CC(OC2O3)C1 492-99-9 1,2-cyclohexanedionedioxime C6H10N2O2 142.16 ON=C1CCCCC1=NO 56-04-2 metacil C5H6N2OS 142.18 Oc1nc(S)nc(C)c1 618-41-7 benzenesulfinicacid C6H6O2S 142.18 OS(=O)c1ccccc1 5455-24-3 octane-4,5-dione C8H14O2 142.20 CCCC(=O)C(CCC)=O 585-07-9 TERT.-BUTYLMETHACRYLAT C8H14O2 142.20 CC(C)(C)OC(=O)C(C)=C 585-25-1 octane-2,3-dione C8H14O2 142.20 CCCCCC(=O)C(C)=O 1460-16-8 cycloheptanecarboxylate C8H14O2 142.20 OC(C1CCCCCC1)=O 5292-21-7 CYCLOHEXANESSIGSAEURE C8H14O2 142.20 OC(CC1CCCCC1)=O 97-88-1 2-METHYL-2-PROPENSAEUREBUTYLESTER C8H14O2 142.20 CCCCOC(=O)C(C)=C 97-86-9 2-METHYL-2-PROPENSAEURE-2-METHYLPROPYLESTER C8H14O2 142.20 CC(C)COC(=O)C(C)=C 2396-83-0 3-hexenoicacidethylester C8H14O2 142.20 CCOC(CC=CCC)=O 4630-82-4 METHYLCYCLOHEXANCARBOXYLAT C8H14O2 142.20 COC(C1CCCCC1)=O 1552-67-6 2-hexenoicacidethylester C8H14O2 142.20 CCCC=CC(OCC)=O 142-30-3 2,5-DIMETHYL-3-HEXIN-2,5-DIOL C8H14O2 142.20 OC(C)(C)C#CC(O)(C)C 622-45-7 ESSIGSAEURECYCLOHEXYLESTER C8H14O2 142.20 CC(OC1CCCCC1)=O 1123-27-9 1-(1-hydroxycyclohexyl)ethanone C8H14O2 142.20 OC1(CCCCC1)C(C)=O 104-50-7 5-BUTYLDIHYDRO-2(3H)-FURANON C8H14O2 142.20 CCCCC1OC(CC1)=O 698-76-0 TETRAHYDRO-6-PROPYL-2H-PYRAN-2-ON C8H14O2 142.20 CCCC1OC(CCC1)=O 1626-09-1 2,7-OCTANDION C8H14O2 142.20 CC(CCCCC(C)=O)=O 106538-38-9 2-OXOLAN-2-YLOXOLANE C8H14O2 142.20 O(CCC1C2CCOC2)C1 90-12-0 1-METHYLNAPHTHALIN C11H10 142.20 Cc2c1ccccc1ccc2 91-57-6 2-METHYLNAPHTHALIN C11H10 142.20 Cc2cc1ccccc1cc2 40326-01-0 2,6-dimethylhept-6-en-1-ol C9H18O 142.24 OCC(C)CCCC(C)=C 7786-29-0 OCTANAL,2-METHYL- C9H18O 142.24 CCCCCCC(C)C=O

Page 61 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 2570-97-0 3-ETHYLHEPTANAL C9H18O 142.24 CCCCC(CC)CC=O 124-19-6 1-NONANAL C9H18O 142.24 CCCCCCCCC=O 5435-64-3 3,5,5-TRIMETHYLHEXANAL C9H18O 142.24 CC(C)(C)CC(C)CC=O 35854-86-5 (z)-non-6-en-1-ol C9H18O 142.24 OCCCCCC=CCC 108-83-8 2,6-DIMETHYL-4-HEPTANON C9H18O 142.24 CC(C)CC(CC(C)C)=O 10340-23-5 (z)-non-3-en-1-ol C9H18O 142.24 CCCCCC=CCCO 41453-56-9 (z)-non-2-en-1-ol C9H18O 142.24 CCCCCCC=CCO 815-24-7 2,2,4,4-TETRAMETHYL-3-PENTANON C9H18O 142.24 CC(C)(C)C(C(C)(C)C)=O 31502-14-4 (e)-non-2-en-1-ol C9H18O 142.24 CCCCCCC=CCO 4485-09-0 4-NONANON C9H18O 142.24 CCCCCC(CCC)=O 925-78-0 3-NONANON C9H18O 142.24 CCCCCCC(CC)=O 502-56-7 5-NONANON C9H18O 142.24 CCCCC(CCCC)=O 821-55-6 2-NONANON C9H18O 142.24 CCCCCCCC(C)=O 2579-20-6 1,3-cyclohexanedimethanamine C8H18N2 142.24 NCC1CC(CN)CCC1 767-54-4 trans-3,3,5-trimethylcyclohexanol C9H18O 142.24 OC(CC(C)CC1(C)C)C1 13475-81-5 2,2,3,3-TETRAMETHYLHEXAN C10H22 142.28 CCCC(C)(C)C(C)(C)C 1071-81-4 2,2,5,5-TETRAMETHYLHEXAN C10H22 142.28 CC(C)(C)CCC(C)(C)C 2613-61-8 2,4,6-TRIMETHYLHEPTAN C10H22 142.28 CC(C)CC(C)CC(C)C 1190-83-6 2,2,6-TRIMETHYLHEPTAN C10H22 142.28 CC(C)CCCC(C)(C)C 7154-80-5 3,3,5-TRIMETHYLHEPTAN C10H22 142.28 CCC(C)CC(C)(C)CC 1189-99-7 2,5,5-TRIMETHYLHEPTAN C10H22 142.28 CC(C)CCC(C)(C)CC 4032-94-4 2,4-DIMETHYLOCTAN C10H22 142.28 CCCCC(C)CC(C)C 4032-92-2 2,4,4-TRIMETHYLHEPTAN C10H22 142.28 CCCC(C)(C)CC(C)C 4032-93-3 2,3,6-TRIMETHYLHEPTAN C10H22 142.28 CC(C)CCC(C)C(C)C 15869-87-1 2,2-DIMETHYLOCTAN C10H22 142.28 CCCCCCC(C)(C)C 2051-30-1 2,6-DIMETHYLOCTAN C10H22 142.28 CCC(C)CCCC(C)C 4110-44-5 3,3-DIMETHYLOCTAN C10H22 142.28 CCCCCC(C)(C)CC 15869-89-3 2,5-DIMETHYLOCTAN C10H22 142.28 CCCC(C)CCC(C)C 1072-16-8 2,7-DIMETHYLOCTAN C10H22 142.28 CC(C)CCCCC(C)C 113486-29-6 3-methylnonane C10H22 142.28 CCCCCCC(C)CC 15869-85-9 5-METHYLNONAN C10H22 142.28 CCCCC(C)CCCC 17301-94-9 4-METHYLNONAN C10H22 142.28 CCCCCC(C)CCC 5911-04-6 3-METHYLNONAN C10H22 142.28 CCCCCCC(C)CC 7146-60-3 2,3-DIMETHYLOCTAN C10H22 142.28 CCCCCC(C)C(C)C 871-83-0 2-METHYLNONAN C10H22 142.28 CCCCCCCC(C)C 124-18-5 DECAN C10H22 142.28 CCCCCCCCCC 695-99-8 MONOCHLORCHINON C6H3ClO2 142.54 ClC1=CC(=O)C=CC1=O 873-63-2 m-chlorobenzylalcohol C7H7ClO 142.58 OCc1cc(Cl)ccc1 873-76-7 4-CHLORBENZOLMETHANOL C7H7ClO 142.58 OCc1ccc(Cl)cc1 87-64-9 6-CHLOR-1,2-KRESOL C7H7ClO 142.58 Cc1cccc(Cl)c1O 615-74-7 2-chloro-5-methylphenol C7H7ClO 142.58 Cc(ccc1Cl)cc1O 608-26-4 5-methyl-2-chlorophenol C7H7ClO 142.58 Cc(ccc1Cl)cc1O 766-51-8 2-CHLORANISOL C7H7ClO 142.58 COc1ccccc1Cl 623-12-1 1-CHLOR-4-METHOXYBENZOL C7H7ClO 142.58 COc1ccc(Cl)cc1 59-50-7 4-CHLOR-3-METHYLPHENOL C7H7ClO 142.58 Oc(ccc1Cl)cc1C 1570-64-5 4-CHLOR-2-METHYLPHENOL C7H7ClO 142.58 Clc(ccc1O)cc1C 615-62-3 3-chloro-4-methylphenol C7H7ClO 142.58 Oc(ccc1C)cc1Cl 2845-89-8 3-CHLORANISOL C7H7ClO 142.58 COc1cc(Cl)ccc1 95-83-0 4-chloro-1,2-benzenediamine C6H7ClN2 142.59 Clc(ccc1N)cc1N 10147-36-1 PROPYLSULFONYLCHLORID C3H7ClO2S 142.61 CCCS(Cl)(=O)=O 4206-75-1 silane,chlorophenyl- C6H7ClSi 142.66 Cl[SiH2]c1ccccc1 358-99-6 1-bromo-1,2-difluoroethylene C2HBrF2 142.93 FC=C(F)Br 627-11-2 CHLORETHYLCHLORKOHLENSAEUREESTER C3H4Cl2O2 142.97 ClCCOC(Cl)=O 116-54-1 DICHLORESSIGSAEUREMETHYLESTER C3H4Cl2O2 142.97 COC(C(Cl)Cl)=O 565-64-0 2,3-dichloropropionicacid C3H4Cl2O2 142.97 ClCC(Cl)C(O)=O 75-99-0 2,2-DICHLORPROPIONSAEURE C3H4Cl2O2 142.97 CC(Cl)(Cl)C(O)=O 623-46-1 A,B-DICHLOROETHYLETHER C4H8Cl2O 143.01 CCOC(Cl)CCl 597-32-0 1,3-dichloro-2-methyl-2-propanol C4H8Cl2O 143.01 ClCC(O)(C)CCl 111-44-4 BIS-(2-CHLORETHYL)-ETHER C4H8Cl2O 143.01 ClCCOCCCl 4375-83-1 HEXAMETHYLBORANTRIAMIN C6H18BN3 143.04 CN(C)B(N(C)C)N(C)C 7488-56-4 seleniumdisulfide S2Se 143.09 S=[Se]=S 1719-57-9 DIMETHYLCHLORMETHYLCHLORSILAN C3H8Cl2Si 143.09 ClC[Si](C)(C)Cl

Page 62 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 4525-44-4 dichloro-ethyl-methylsilane C3H8Cl2Si 143.09 CC[Si](C)(Cl)Cl 118-78-5 uramil C4H5N3O3 143.10 NC1C(=O)NC(=O)NC1=O 127-48-0 trimethadione C6H9NO3 143.14 CC1(C)OC(=O)N(C)C1=O 27032-01-5 PYRIDINDICYANOMETHANID C8H5N3 143.15 N#CC(C#N)=n1ccccc1 635-90-5 1-phenylpyrrole C10H9N 143.19 c(cc2)ccc2n1cccc1 611-32-5 8-METHYLCHINOLIN C10H9N 143.19 Cc2c1ncccc1ccc2 134-32-7 1-NAPHTHALINAMIN C10H9N 143.19 Nc2c1ccccc1ccc2 91-59-8 2-NAPHTHALINAMIN C10H9N 143.19 Nc2cc1ccccc1cc2 3042-22-6 2-PHENYL-1H-PYRROL C10H9N 143.19 c(cc2)ccc2c1[nH]ccc1 91-63-4 2-METHYLCHINOLIN C10H9N 143.19 Cc2nc1ccccc1cc2 612-58-8 3-METHYLCHINOLIN C10H9N 143.19 Cc2cc1ccccc1nc2 612-60-2 7-METHYLCHINOLIN C10H9N 143.19 Cc2cc1ncccc1cc2 91-62-3 6-METHYLCHINOLIN C10H9N 143.19 Cc2cc1cccnc1cc2 1721-93-3 1-METHYLISOCHINOLIN C10H9N 143.19 Cc2c1ccccc1ccn2 491-35-0 4-METHYLCHINOLIN C10H9N 143.19 Cc2c1ccccc1ncc2 1125-80-0 3-METHYLISOCHINOLIN C10H9N 143.19 Cc2cc1ccccc1cn2 137-00-8 2-(4-methyl-1,3-thiazol-5-yl)ethanol C6H9NOS 143.21 OCCc1scnc1C 495-20-5 conhydrine C8H17NO 143.23 CCC(O)C1CCCCN1 629-01-6 OCTANAMID C8H17NO 143.23 CCCCCCCC(=O)N 1005-67-0 4-BUTYLMORPHOLIN C8H17NO 143.23 CCCCN1CCOCC1 1114-76-7 N,N-DIETHYLBUTANAMID C8H17NO 143.23 CCCC(=O)N(CC)CC 1116-24-1 DI-N-PROPYLACETAMID C8H17NO 143.23 CCCN(CCC)C(C)=O 76788-46-0 2-ethyl-4,5-dimethyl-2,5-dihydro-1,3-thiazole C7H13NS 143.25 CCC(SC1C)N=C1C 112-20-9 1-NONANAMIN C9H21N 143.27 NCCCCCCCCC 102-69-2 N,N-DIPROPYL-1-PROPANAMIN C9H21N 143.27 CCCN(CCC)CCC 107-04-0 1-BROM-2-CHLORETHAN C2H4BrCl 143.41 ClCCBr 593-96-4 1-BROM-1-CHLORETHAN C2H4BrCl 143.41 CC(Cl)Br 95-85-2 2-amino-4-chlorophenol C6H6ClNO 143.57 Clc(ccc1O)cc1N 594-72-9 1,1-DICHLOR-1-NITROETHAN C2H3Cl2NO2 143.96 CC(Cl)(Cl)N(=O)=O 155-16-8 1-methyl-5-fluorouracil C5H5FN2O2 144.10 Fc1cn(C)c(=O)[nH]c1=O 624-49-7 DIMETHYLFUMARSAEUREESTER C6H8O4 144.13 COC(=O)C=CC(OC)=O 624-48-6 (2Z)-2-BUTENDISAEUREDIMETHYLESTER C6H8O4 144.13 COC(=O)C=CC(OC)=O 5445-51-2 1,1-CYCLOBUTANDICARBONSAEURE C6H8O4 144.13 OC(C1(CCC1)C(O)=O)=O 24615-84-7 2-PROPENOICACID,2-CARBOXYETHYLESTER C6H8O4 144.13 OC(CCOC(=O)C=C)=O 95-96-5 3,6-DIMETHYL-1,4-DIOXAN-2,5-DION C6H8O4 144.13 CC1OC(C(C)OC1=O)=O 2033-24-1 2,2-dimethyl-1,3-dioxane-4,6-dione C6H8O4 144.13 CC1(C)OC(CC(O1)=O)=O 638-20-0 1,3-diacetylurea C5H8N2O3 144.13 CC(=O)NC(=O)NC(C)=O 140-79-4 1,4-DINITROSOPIPERAZIN C4H8N4O2 144.13 O=NN1CCN(CC1)N=O 6876-44-4 TRIFLUORESSIGSAEURESILYLESTER C2H3F3O2Si 144.13 [SiH3]OC(C(F)(F)F)=O 4759-11-9 11-oxabicyclo[4.4.1]undeca-1,3,5,7,9-pentaene C10H8O 144.17 c(cc2)cc1=CC=CC=c2o1 609-14-3 2-METHYL-3-OXOBUTANSAEUREETHYLESTER C7H12O3 144.17 CCOC(C(C)C(C)=O)=O 542-08-5 3-oxobutanoicacid-1-methylethylester C7H12O3 144.17 CC(C)OC(CC(C)=O)=O 27761-61-1 1,4-DIMETHYL-2,6,7-TRIOXABICYCLO[2.2.2]OCTAN C7H12O3 144.17 CC1(OC2)OCC2(C)CO1 923-26-2 2-HYDROXYPROPYLMETHACRYLAT C7H12O3 144.17 OC(C)COC(=O)C(C)=C 578-66-5 8-CHINOLINAMIN C9H8N2 144.17 Nc2c1ncccc1ccc2 106-74-1 2-ethoxyethylacrylate C7H12O3 144.17 CCOCCOC(=O)C=C 539-88-8 LAEVULINSAEUREETHYLESTER C7H12O3 144.17 CCOC(CCC(C)=O)=O 670-96-2 2-PHENYL-1H-IMIDAZOL C9H8N2 144.17 c(cc2)ccc2c1[nH]ccn1 13708-12-8 5-METHYLCHINOXALIN C9H8N2 144.17 Cc1cccc2c1nccn2 38425-47-7 3-phenylcyclobutenone C10H8O 144.17 O=C(C1)C=C1c2ccccc2 637-64-9 TETRAHYDRO-2-FURANMETHANOLACETAT C7H12O3 144.17 CC(OCC1CCCO1)=O 1532-84-9 1-isoquinolinamine C9H8N2 144.17 Nc2c1ccccc1ccn2 580-22-3 2-aminoquinoline C9H8N2 144.17 Nc2nc1ccccc1cc2 580-17-6 3-CHINOLINAMIN C9H8N2 144.17 Nc2cc1ccccc1nc2 611-34-7 5-CHINOLINAMIN C9H8N2 144.17 Nc2c1cccnc1ccc2 1125-60-6 5-isoquinolinamine C9H8N2 144.17 Nc2c1ccncc1ccc2 578-68-7 4-CHINOLINAMIN C9H8N2 144.17 Nc2c1ccccc1ncc2 580-15-4 6-CHINOLINAMIN C9H8N2 144.17 Nc2cc1cccnc1cc2 135-19-3 2-NAPHTHALENOL C10H8O 144.17 Oc2cc1ccccc1cc2 90-15-3 1-NAPHTHOL C10H8O 144.17 Oc2c1ccccc1ccc2 112-23-2 AMEISENSAEUREHEPTYLESTER C8H16O2 144.21 CCCCCCCOC=O 124-07-2 OCTANSAEURE C8H16O2 144.21 CCCCCCCC(O)=O

Page 63 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 149-57-5 2-ETHYLHEXANSAEURE C8H16O2 144.21 CCCCC(CC)C(O)=O 99-66-1 2-PROPYLPENTANSAEURE C8H16O2 144.21 CCCC(CCC)C(O)=O 97-85-8 2-METHYLPROPANSAEURE-2-METHYLPROPYLESTER C8H16O2 144.21 CC(C)COC(C(C)C)=O 557-00-6 3-METHYLBUTANSAEUREPROPYLESTER C8H16O2 144.21 CCCOC(CC(C)C)=O 109-21-7 BUTYLBUTYRAT C8H16O2 144.21 CCCCOC(CCC)=O 106-73-0 HEPTANSAEUREMETHYLESTER C8H16O2 144.21 CCCCCCC(OC)=O 141-06-0 PENTANSAEUREPROPYLESTER C8H16O2 144.21 CCCOC(CCCC)=O 624-54-4 PROPANSAEUREPENTYLESTER C8H16O2 144.21 CCCCCOC(CC)=O 105-68-0 3-METHYL-1-BUTANOLPROPANOAT C8H16O2 144.21 CC(C)CCOC(CC)=O 123-66-0 HEXANSAEUREETHYLESTER C8H16O2 144.21 CCCCCC(OCC)=O 539-90-2 BUTANSAEURE-2-METHYLPROPYLESTER C8H16O2 144.21 CC(C)COC(CCC)=O 105-08-8 1,4-BIS-(HYDROXYMETHYL)-CYCLOHEXAN C8H16O2 144.21 OCC1CCC(CO)CC1 142-92-7 ESSIGSAEUREHEXYLESTER C8H16O2 144.21 CCCCCCOC(C)=O 108-84-9 ESSIGSAEURE-4-METHYLPENTYL-2-ESTER C8H16O2 144.21 CC(C)CC(C)OC(C)=O 18318-83-7 1,1-dimethoxyhex-2-ene C8H16O2 144.21 CCCC=CC(OC)OC 496-77-5 5-hydroxyoctan-4-one C8H16O2 144.21 CCCC(O)C(CCC)=O 65405-68-7 3-(hydroxymethyl)heptan-2-one C8H16O2 144.21 CCCCC(CO)C(C)=O 16262-48-9 BENZENE,1-ETHENYL-4-(1-METHYLETHENYL)- C11H12 144.21 CC(=C)c(cc1)ccc1C=C 629-17-4 thiocyanicacid-1,2-ethanediylester C4H4N2S2 144.22 N#CSCCSC#N 2001-93-6 2,4(1h,3h)pyrimidinedithione C4H4N2S2 144.22 S=c1[nH]c([nH]cc1)=S 123-00-2 4-MORPHOLINPROPANAMIN C7H16N2O 144.22 NCCCN1CCOCC1 94089-02-8 1-thiophen-2-ylethanethiol C6H8S2 144.26 CC(S)c1sccc1 1969-43-3 1-ETHOXYHEPTAN C9H20O 144.26 CCOCCCCCCC 3452-97-9 3,5,5-TRIMETHYL-1-HEXANOL C9H20O 144.26 OCCC(C)CC(C)(C)C 3525-25-5 1-HEPTANOL,3-ETHYL- C9H20O 144.26 CCCCC(CC)CCO 38514-05-5 1-OCTANOL,6-METHYL- C9H20O 144.26 OCCCCCC(C)CC 628-99-9 2-NONANOL C9H20O 144.26 CCCCCCCC(O)C 628-44-4 2-METHYL-2-OCTANOL C9H20O 144.26 CCCCCCC(O)(C)C 38514-03-3 1-OCTANOL,4-METHYL- C9H20O 144.26 OCCCC(C)CCCC 2430-22-0 7-METHYL-1-OCTANOL C9H20O 144.26 OCCCCCCC(C)C 111-51-3 N,N,N`,N`-TETRAMETHYL-1,4-DIAMINOBUTAN C8H20N2 144.26 CN(C)CCCCN(C)C 373-44-4 1,8-OCTANDIAMIN C8H20N2 144.26 NCCCCCCCCN 143-08-8 1-NONANOL C9H20O 144.26 OCCCCCCCCC 1573-28-0 3,6-DIMETHYL-3-HEPTANOL C9H20O 144.26 CC(C)CCC(O)(C)CC 623-93-8 5-NONANOL C9H20O 144.26 CCCCC(O)CCCC 597-90-0 4-ETHYL-4-HEPTANOL C9H20O 144.26 CCCC(O)(CC)CCC 108-82-7 2,6-DIMETHYL-4-HEPTANOL C9H20O 144.26 CC(C)CC(O)CC(C)C 631-36-7 TETRAETHYLSILAN C8H20Si 144.33 CC[Si](CC)(CC)CC 545-06-2 TRICHLORACETONITRIL C2Cl3N 144.39 ClC(Cl)(Cl)C#N 82375-49-3 2-chloroethylphosphonic acid C2H6ClO3P 144.49 ClCCP(O)(O)=O 1722-10-7 3-chloro-6-methoxypyridazine C5H5ClN2O 144.56 COc1ccc(Cl)nn1 615-67-8 CHLORHYDROCHINON C6H5ClO2 144.56 Oc(ccc1O)cc1Cl 4018-65-9 3-chlorocatechol C6H5ClO2 144.56 Oc1cccc(Cl)c1O 95-88-5 4-CHLOR-1,3-BENZOLDIOL C6H5ClO2 144.56 Oc(ccc1Cl)cc1O 2138-22-9 4-CHLOR-1,2-BENZOLDIOL C6H5ClO2 144.56 Clc(ccc1O)cc1O 443-83-4 1-CHLOR-3-FLUOR-2-METHYLBENZOL C7H6ClF 144.57 Fc1cccc(Cl)c1C 625-01-4 CHLORSCHWEFELSAEUREETHYLESTER C2H5ClO3S 144.58 CCOS(Cl)(=O)=O 113-18-8 ethchlorvynol C7H9ClO 144.60 CCC(O)(C#C)C=CCl 106-54-7 4-CHLORBENZOLTHIOL C6H5ClS 144.62 Clc1ccc(S)cc1 2037-31-2 3-chlorobenzenethiol C6H5ClS 144.62 Clc1cc(S)ccc1 7783-08-6 SELENSAEURE H2O4Se 144.98 O[Se](O)(=O)=O 121-66-4 5-nitro-2-thiazolamine C3H3N3O2S 145.14 Nc1sc(cn1)N(=O)=O 148-24-3 8-CHINOLINOL C9H7NO 145.16 Oc2c1ncccc1ccc2 611-36-9 4-CHINOLINOL C9H7NO 145.16 Oc2c1ccccc1ncc2 578-67-6 5-quinolinol C9H7NO 145.16 Oc2c1cccnc1ccc2 580-20-1 7-quinolinol C9H7NO 145.16 Oc2cc1ncccc1cc2 580-16-5 6-CHINOLINOL C9H7NO 145.16 Oc2cc1cccnc1cc2 1443-80-7 p-cyanoacetophenone C9H7NO 145.16 CC(=O)c(cc1)ccc1C#N 614-16-4 BETA-OXOBENZOLPROPANNITRIL C9H7NO 145.16 N#CCC(=O)c1ccccc1 760-60-1 n-(2-methylpropyl)-n-nitroso-urea C5H11N3O2 145.16 CC(C)CN(N=O)C(=O)N 487-89-8 1H-INDOL-3-CARBOXALDEHYD C9H7NO 145.16 O=Cc1c[nH]c2c1cccc2 491-30-5 2-ISOCHINOLINOL C9H7NO 145.16 O=C2NC=Cc1ccccc21

Page 64 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 59-31-4 2(1h)-quinolinone C9H7NO 145.16 O=C2C=Cc1ccccc1N2 1532-72-5 isoquinolineoxide C9H7NO 145.16 O=n2cc1ccccc1cc2 91-55-4 2,3-DIMETHYL-1H-INDOL C10H11N 145.20 Cc2[nH]c1ccccc1c2C 2114-20-7 HEXYLCARBAMAT C7H15NO2 145.20 CCCCCNC(OC)=O 78-28-4 3-methyl-3-pentanolcarbamate C7H15NO2 145.20 CCC(C)(CC)OC(=O)N 2571-52-0 MESITYLNITRIL C10H11N 145.20 Cc(cc1C)cc(C)c1C#N 769-68-6 2-PHENYL-BUTYRONITRIL C10H11N 145.20 CCC(C#N)c1ccccc1 10220-23-2 METHOXYETHYLMORPHOLIN C7H15NO2 145.20 COCCN1CCOCC1 693-39-0 1-NITROHEPTAN C7H15NO2 145.20 CCCCCCCN(=O)=O 875-79-6 1,2-DIMETHYL-1H-INDOL C10H11N 145.20 Cc2cc1ccccc1n2C 875-30-9 1,3-dimethyl-1h-indole C10H11N 145.20 Cc2c1ccccc1n(C)c2 96-80-0 2-(DIISOPROPYLAMINO)-ETHANOL C8H19NO 145.24 OCCN(C(C)C)C(C)C 105-83-9 N-METHYLDIPROPYLENTRIAMIN C7H19N3 145.25 NCCCN(C)CCCN 96-19-5 1,2,3-TRICHLORPROPEN C3H3Cl3 145.42 ClCC(Cl)=CCl 2567-14-8 1,1,3-TRICHLOR-1-PROPEN C3H3Cl3 145.42 ClCC=C(Cl)Cl 2233-00-3 3,3,3-trichloro-1-propene C3H3Cl3 145.42 ClC(Cl)(Cl)C=C 367-21-5 3-CHLOR-4-FLUORBENZOLAMIN C6H5ClFN 145.56 Nc(ccc1F)cc1Cl 13873-84-2 IODFLUORID FI 145.90 FI 2551-62-4 (OC-6-11)-SCHWEFELFLUORID(SF6) F6S 146.06 FS(F)(F)(F)(F)F 512-51-6 1-ETHOXY-1,1,2,2-TETRAFLUORETHAN C4H6F4O 146.08 CCOC(F)(F)C(F)F 328-50-7 2-OXOPENTANDISAEURE C5H6O5 146.10 OC(=O)CCC(=O)C(O)=O 542-05-2 3-oxopentanedioicacid C5H6O5 146.10 OC(CC(CC(O)=O)=O)=O 98-08-8 (TRIFLUORMETHYL)-BENZOL C7H5F3 146.11 FC(F)(F)c1ccccc1 609-02-9 METHYLPROPIONDISAEUREDIMETHYLESTER C6H10O4 146.14 COC(C(C)C(OC)=O)=O 542-10-9 1,1-ETHANDIOLDIACETAT C6H10O4 146.14 CC(OC(C)=O)OC(C)=O 95-92-1 ETHANDISAEUREDIETHYLESTER C6H10O4 146.14 CCOC(=O)C(OCC)=O 1070-34-4 butanedioicacidmonoethylester C6H10O4 146.14 CCOC(CCC(O)=O)=O 491-31-6 1h-2-benzopyran-1-one C9H6O2 146.14 O=C2c1ccccc1C=CO2 597-43-3 2,2-DIMETHYL-1,4-BUTANDISAEURE C6H10O4 146.14 CC(C(C)C(O)=O)C(O)=O 106-65-0 BUTANDISAEUREDIMETHYLESTER C6H10O4 146.14 COC(CCC(OC)=O)=O 606-23-5 1,3-indandione C9H6O2 146.14 O=C2c1ccccc1C(C2)=O 91-64-5 2H-1-BENZOPYRAN-2-ON C9H6O2 146.14 O=C2C=Cc1ccccc1O2 111-55-7 1,2-ETHANDIOLDIACETAT C6H10O4 146.14 CC(OCCOC(C)=O)=O 626-51-7 3-methylglutaricacid C6H10O4 146.14 CC(CC(O)=O)CC(O)=O 491-38-3 4H-1-BENZOPYRAN-4-ON C9H6O2 146.14 O=C2C=COc1ccccc21 124-04-9 HEXANDISAEURE C6H10O4 146.14 OC(CCCCC(O)=O)=O 652-67-5 ISOSORBIT C6H10O4 146.14 OC1COC2C1OCC2O 5378-52-9 1-PHENYL-1H-TETRAZOL C7H6N4 146.15 c(cc1)ccc1n2cnnn2 119-39-1 1-(2H)-PHTHALAZINON C8H6N2O 146.15 O=C2NN=Cc1ccccc21 18039-42-4 1h-tetrazole,5-phenyl- C7H6N4 146.15 c(cc1)ccc1c2[nH]nnn2 936-40-3 7-methylpteridine C7H6N4 146.15 Cc2nc1ncncc1nc2 491-36-1 quinazolidin-4-one C8H6N2O 146.15 O=C2NC=Nc1ccccc21 56-85-9 L-GLUTAMIN C5H10N2O3 146.15[NH3+]C(CCC(=O)N)C([O-])=O 323-09-1 2-FLUORNAPHTHALIN C10H7F 146.16 Fc2cc1ccccc1cc2 321-38-0 1-FLUORNAPHTHALIN C10H7F 146.16 Fc2c1ccccc1ccc2 623-96-1 KOHLENSAEUREDIPROPYLESTER C7H14O3 146.19 CCCOC(OCCC)=O 936-53-8 4,5-dihydro-1-phenyl-1h-pyrazole C9H10N2 146.19 C(C1)C=NN1c2ccccc2 138-22-7 2-HYDROXYPROPANSAEUREBUTYLESTER C7H14O3 146.19 CCCCOC(C(O)C)=O 127-66-2 a-ethynyl-a-methylbenzenemethanol C10H10O 146.19 OC(C)(C#C)c1ccccc1 495-41-0 1-phenyl-2-buten-1-one C10H10O 146.19 CC=CC(c1ccccc1)=O 763-69-9 3-ETHOXYPROPIONSAEUREETHYLESTER C7H14O3 146.19 CCOCCC(OCC)=O 54839-24-6 2-PROPANOL,1-ETHOXY,-ACETATE C7H14O3 146.19 CCOCC(C)OC(C)=O 148462-57-1 2-propanol-1-methoxy-propanoate C7H14O3 146.19 COCC(C)OC(CC)=O 530-93-8 3,4-DIHYDRO-2(1H)-NAPHTHALINON C10H10O 146.19 O=C2Cc1ccccc1CC2 529-34-0 TETRALON C10H10O 146.19 O=C2c1ccccc1CCC2 936-48-1 4,5-dihydro-3-phenyl-1h-pyrazole C9H10N2 146.19 C(C1)NN=C1c2ccccc2 582-60-5 5,6-dimethylbenzimidazole C9H10N2 146.19 Cc2cc1nc[nH]c1cc2C 122-57-6 4-PHENYL-3-BUTEN-2-ON C10H10O 146.19 CC(=O)C=Cc1ccccc1 1197-19-9 p-cyano-n,n-dimethylaniline C9H10N2 146.19 CN(C)c1ccc(C#N)cc1 10410-35-2 3,5-DIMETHYLBENZOFURAN C10H10O 146.19 Cc2cc1c(cc2)occ1C 3782-00-1 2,3-DIMETHYLBENZOFURAN C10H10O 146.19 Cc2oc1ccccc1c2C 56-87-1 L-LYSYIN C6H14N2O2 146.19 NCCCCC([NH3+])C([O-])=O

Page 65 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 1117-86-8 1,2-OCTANDIOL C8H18O2 146.23 CCCCCCC(O)CO 94-96-2 2-ETHYL-1,3-HEXANDIOL C8H18O2 146.23 CCCC(O)C(CO)CC 144-19-4 2,2,4-TRIMETHYLPENTAN-1,3-DIOL C8H18O2 146.23 OCC(C)(C)C(O)C(C)C 629-41-4 1,8-OCTANDIOL C8H18O2 146.23 OCCCCCCCCO 110-03-2 2,5-DIMETHYL-2,5-HEXANDIOL C8H18O2 146.23 OC(C)(C)CCC(O)(C)C 112-25-4 2-(HEXYLOXY)ETHANOL C8H18O2 146.23 OCCOCCCCCC 112-24-3 TRIETHYLENTETRAMIN C6H18N4 146.23 NCCNCCNCCN 110-05-4 DI-TERT.-BUTYLPEROXID C8H18O2 146.23 CC(C)(C)OOC(C)(C)C 1075-74-7 4-PENTENYLBENZOL C11H14 146.23 C=CCCCc1ccccc1 826-18-6 1-pentenylbenzene C11H14 146.23 CCCC=Cc1ccccc1 769-25-5 2,4,6-TRIMETHYL-1-VINYLBENZOL C11H14 146.23 Cc(cc1C)cc(C)c1C=C 700-88-9 CYCLOPENTYLBENZOL C11H14 146.23 C(CCC1c2ccccc2)C1 2809-64-5 5-METHYL-1,2,3,4-TETRAHYDRONAPHTALIN C11H14 146.23 Cc2c1CCCCc1ccc2 1559-81-5 1,2,3,4-TETRAHYDRO-1-METHYLNAPHTHALEN C11H14 146.23 CC2c1ccccc1CCC2 3877-19-8 1,2,3,4-TETRAHYDRO-2-METHYLNAPHTHALIN C11H14 146.23 CC2Cc1ccccc1CC2 1680-51-9 1,2,3,4-TETRAHYDRO-6-METHYLNAPHTHALIN C11H14 146.23 Cc2cc1CCCCc1cc2 23550-40-5 4-methyl-4-methylsulfanylpentan-2-one C7H14OS 146.25 CSC(C)(C)CC(C)=O 463-18-3 1-FLUORNONAN C9H19F 146.25 FCCCCCCCCC 107-47-1 DI-TERT.-BUTYLSULFIDE C8H18S 146.29 CC(C)(C)SC(C)(C)C 544-40-1 5-THIANONAN C8H18S 146.29 CCCCSCCCC 141-59-3 2-PENTANETHIOL,2,4,4-TRIMETHYL- C8H18S 146.29 CC(C)(C)CC(C)(C)S 111-88-6 1-OCTANTHIOL C8H18S 146.29 CCCCCCCCS 626-26-6 3,5-DIMETHYL-4-THIAHEPTAN C8H18S 146.29 CCC(C)SC(C)CC 7341-17-5 2-ethylhexane-1-thiol C8H18S 146.29 CCCCC(CC)CS 592-65-4 2,6-DIMETHYL-4-THIAHEPTAN C8H18S 146.29 CC(C)CSCC(C)C 1450-14-2 HEXAMETHYLDISILAN C6H18Si2 146.38 C[Si](C)(C)[Si](C)(C)C 2719-27-9 CYCLOHEXANCARBONYLCHLORID C7H11ClO 146.62 ClC(C1CCCCC1)=O 106-46-7 1,4-DICHLORBENZOL C6H4Cl2 147.00 Clc1ccc(Cl)cc1 541-73-1 1,3-DICHLORBENZOL C6H4Cl2 147.00 Clc1cc(Cl)ccc1 95-50-1 1,2-DICHLORBENZOL C6H4Cl2 147.00 Clc1ccccc1Cl 70-25-7 n-nitroso-n-methyl-n'-nitroguanidine C2H5N5O3 147.09 CN(N=O)C(=N)NN(=O)=O 2531-80-8 2-nitropropanoicacidethylester C5H9NO4 147.13 CCOC(=O)C(C)N(=O)=O 582-61-6 benzoylazide C7H5N3O 147.13 N#N=NC(c1ccccc1)=O 85-41-6 1H-ISOINDOL-1,3(2H)-DION C8H5NO2 147.13 O=C2NC(c1ccccc21)=O 1877-72-1 3-CYANOBENZOESAEURE C8H5NO2 147.13 OC(=O)c(ccc1)cc1C#N 619-65-8 4-CYANOBENZOESAEURE C8H5NO2 147.13 OC(=O)c(cc1)ccc1C#N 91-56-5 ISATIN C8H5NO2 147.13 O=C2c1ccccc1NC2=O 90-16-4 1,2,3-benzotriazin-4(1h)-one C7H5N3O 147.13 O=C2NN=Nc1ccccc21 56-86-0 L-GLUTAMINSAEURE C5H9NO4 147.13OC(CCC([NH3+])C([O-])=O)=O 700-81-2 2-pteridinamine C6H5N5 147.14 Nc2nc1nccnc1cn2 769-66-4 7-pteridinamine C6H5N5 147.14 Nc2nc1ncncc1nc2 1438-94-4 1-(furan-2-ylmethyl)pyrrole C9H9NO 147.17 C(c2occc2)n1cccc1 104-47-2 4-METHOXYBENZYLCYANID C9H9NO 147.17 COc1ccc(CC#N)cc1 553-03-7 3,4-dihydro-2(1h)-quinolinone C9H9NO 147.17 O=C2Nc1ccccc1CC2 621-79-4 3-PHENYL-2-PROPENAMID C9H9NO 147.17 O=C(N)C=Cc1ccccc1 1188-33-6 1,1-diethoxy-n,n-dimethylmethanamine C7H17NO2 147.22 CCOC(OCC)N(C)C 2217-41-6 5,6,7,8-tetrahydro-1-naphthalenamine C10H13N 147.22 Nc2c1CCCCc1ccc2 2057-43-4 2-(3-pentenyl)pyridine C10H13N 147.22 CC=CCCc1ccccn1 505-79-3 1-isothiocyanato-3-methylsulfanylpropane C5H9NS2 147.26 CSCCCN=C=S 593-98-6 FLUORCHLORBROMMETHAN CHBrClF 147.37 FC(Cl)Br 79-36-7 DICHLORACETYLCHLORID C2HCl3O 147.39 ClC(Cl)C(Cl)=O 75-87-6 TRICHLORACETALDEHYD C2HCl3O 147.39 ClC(Cl)(Cl)C=O 96-18-4 1,2,3-TRICHLORPROPAN C3H5Cl3 147.43 ClCC(Cl)CCl 598-77-6 1,1,2-TRICHLORPROPAN C3H5Cl3 147.43 CC(Cl)C(Cl)Cl 3175-23-3 1,2,2-TRICHLORPROPAN C3H5Cl3 147.43 ClCC(C)(Cl)Cl 2402-78-0 2,6-DICHLORPYRIDIN C5H3Cl2N 147.99 Clc1nc(Cl)ccc1 2402-77-9 2,3-DICHLORPYRIDIN C5H3Cl2N 147.99 Clc1ncccc1Cl 2457-47-8 3,5-DICHLORPYRIDIN C5H3Cl2N 147.99 Clc1cc(Cl)cnc1 406-58-6 1,1,1,3,3-PENTAFLUORBUTAN C4H5F5 148.07 FC(F)(F)CC(F)(F)C 85-44-9 1,3-ISOBENZOFURANDION C8H4O3 148.12 O=C2c1ccccc1C(O2)=O 619-24-9 3-NITROBENZONITRIL C7H4N2O2 148.12 N#Cc1cc(ccc1)N(=O)=O 619-72-7 4-NITROBENZONITRIL C7H4N2O2 148.12 N#Cc1ccc(cc1)N(=O)=O

Page 66 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 612-24-8 2-CYANONITROBENZENE C7H4N2O2 148.12 N#Cc1ccccc1N(=O)=O 700-47-0 4-hydroxypteridine C6H4N4O 148.12 Oc2c1nccnc1ncn2 1197-40-6 2,2-METHYLENBISFURAN C9H8O2 148.16 C(c2occc2)c1occc1 579-07-7 1-phenyl-1,2-propanedione C9H8O2 148.16 CC(=O)C(c1ccccc1)=O 140-10-3 TRANS-ZIMTSAEURE C9H8O2 148.16 OC(=O)C=Cc1ccccc1 1075-49-6 4-ethenylbenzoicacid C9H8O2 148.16 OC(=O)c(cc1)ccc1C=C 492-38-6 atropicacid C9H8O2 148.16 OC(=O)C(c1ccccc1)=C 119-84-6 3,4-DIHYDRO-2H-1-BENZOPYRAN-2-ON C9H8O2 148.16 O=C2Oc1ccccc1CC2 621-82-9 3-PHENYL-2-PROPENSAEURE(ISOMERENGEMISCH) C9H8O2 148.16 OC(=O)C=Cc1ccccc1 491-37-2 2,3-DIHYDRO-4H-1-BENZOPYRAN-4-ON C9H8O2 148.16 O=C2c1ccccc1OCC2 583-92-6 4-methylsulfanyl-2-oxobutanoic acid C5H8O3S 148.18 CSCCC(=O)C(O)=O 99-72-9 2-(4-methylphenyl)propanal C10H12O 148.20 CC(C=O)c(cc1)ccc1C 530-91-6 1,2,3,4-TETRAHYDRO-2-NAPHTHALENOL C10H12O 148.20 OC2Cc1ccccc1CC2 611-70-1 2-METHYL-1-PHENYL-1-PROPANON C10H12O 148.20 CC(C)C(=O)c1ccccc1 495-40-9 1-PHENYL-1-BUTANON C10H12O 148.20 CCCC(=O)c1ccccc1 122-03-2 4-(1-METHYLETHYL)BENZALDEHYD C10H12O 148.20 CC(C)c1ccc(C=O)cc1 2142-73-6 1-(2,5-DIMETHYLPHENYL)ETHANON C10H12O 148.20 CC(=O)c1cc(C)ccc1C 487-68-3 2,4,6-TRIMETHYLBENZALDEHYD C10H12O 148.20 Cc(cc1C)cc(C)c1C=O 89-74-7 1-(2,4-dimethylphenyl)ethanone C10H12O 148.20 CC(=O)c1ccc(C)cc1C 937-30-4 1,4-ETHYLACETOPHENON C10H12O 148.20 CCc1ccc(C(C)=O)cc1 1007-32-5 1-PHENYL-2-BUTANON C10H12O 148.20 CCC(=O)Cc1ccccc1 122-51-0 TRIETHOXYMETHAN C7H16O3 148.20 CCOC(OCC)OCC 2550-26-7 4-PHENYL-2-BUTANON C10H12O 148.20 CC(CCc1ccccc1)=O 3637-01-2 1-(3,4-DIMETHYLPHENYL)ETHANON C10H12O 148.20 CC(=O)c(ccc1C)cc1C 1125-78-6 5,6,7,8-TETRAHYDRONAPHTHALIN-2-OL C10H12O 148.20 Oc2cc1CCCCc1cc2 529-35-1 5,6,7,8-TETRAHYDRONAPHTHALEN-1-OL C10H12O 148.20 Oc2c1CCCCc1ccc2 6881-94-3 2-(2-PROPOXYETHOXY)ETHANOL C7H16O3 148.20 OCCOCCOCCC 140-67-0 4-ALLYLANISOL C10H12O 148.20 COc1ccc(CC=C)cc1 4180-23-8 TRANS-1-METHOXY-4-(1-PROPENYL)-BENZOL C10H12O 148.20 COc1ccc(C=CC)cc1 34590-94-8 DOWANOL_DPM C7H16O3 148.20 COC(C)COCC(O)C 104-46-1 1-METHOXY-4-(1-PROPENYL)-BENZOL C10H12O 148.20 COc1ccc(C=CC)cc1 103-02-6 ACETONPHENYLHYDRAZON C9H12N2 148.21 CC(C)=NNc1ccccc1 494-97-3 nornicotine C9H12N2 148.21 C(CCC1c2cccnc2)N1 2768-02-7 ETHENYLTRIMETHOXYSILANE C5H12O3Si 148.23 CO[Si](OC)(OC)C=C 1195-14-8 BENZO[B]THIOPHENE,2-METHYL- C9H8S 148.23 Cc2sc1ccccc1c2 4117-15-1 1,10-undecadiyne C11H16 148.25 C#CCCCCCCCC#C 61827-87-0 2-ETHYL-1,3,4-TRIMETHYL-BENZOL C11H16 148.25 CCc(c(C)ccc1C)c1C 2049-95-8 (1,1-DIMETHYLPROPYL)BENZOL C11H16 148.25 CCC(C)(C)c1ccccc1 700-12-9 PENTAMETHYLBENZOL C11H16 148.25 Cc1cc(C)c(C)c(C)c1C 17059-44-8 1,2-DIMETHYL-3-PROPYLBENZOL C11H16 148.25 CCCc(cccc1C)c1C 61827-86-9 BENZENE,1,2,3-TRIMETHYL-4-ETHYL- C11H16 148.25 CCc(ccc1C)c(C)c1C 2049-94-7 (3-METHYLBUTYL)BENZOL C11H16 148.25 CC(C)CCc1ccccc1 18970-44-0 BENZENE,1-ETHYL-2-(1-METHYLETHYL)- C11H16 148.25 CCc1ccccc1C(C)C 1075-38-3 1-METHYL-3-TERT.-BUTYLBENZOL C11H16 148.25 CC(C)(C)c(ccc1)cc1C 2719-52-0 (1-METHYLBUTYL)BENZOL C11H16 148.25 CCCC(C)c1ccccc1 98-51-1 1-(1,1-DIMETHYLETHYL)-4-METHYLBENZOL C11H16 148.25 CC(C)(C)c(cc1)ccc1C 17851-27-3 1-ETHYL-2,4,5-TRIMETHYLBENZOL C11H16 148.25 CCc(cc1C)c(C)cc1C 538-68-1 PENTYLBENZOL C11H16 148.25 CCCCCc1ccccc1 1007-26-7 (2,2-DIMETHYLPROPYL)BENZOL C11H16 148.25 CC(C)(C)Cc1ccccc1 3968-85-2 (2-METHYLBUTYL)BENZOL C11H16 148.25 CCC(C)Cc1ccccc1 4218-48-8 1-ETHYL-4-ISOPROPYLBENZOL C11H16 148.25 CCc1ccc(C(C)C)cc1 2050-24-0 1-METHYL-3,5-DIETHYLBENZOL C11H16 148.25 CCc(c1)cc(CC)cc1C 1196-58-3 (1-ETHYLPROPYL)BENZOL C11H16 148.25 CCC(CC)c1ccccc1 51755-66-9 3-methylsulfanylhexan-1-ol C7H16OS 148.27 OCCC(SC)CCC 78-62-6 DIETHOXYDIMETHYLSILAN C6H16O2Si 148.28 CCO[Si](C)(C)OCC 2179-59-1 3-propyldisulfanylprop-1-ene C6H12S2 148.29 CCCSSCC=C 2528-61-2 HEPTANOYLCHLORID C7H13ClO 148.63 CCCCCCC(Cl)=O 628-61-5 2-CHLOROCTAN C8H17Cl 148.67 CCCCCCC(C)Cl 111-85-3 1-OCTYLCHLORID C8H17Cl 148.67 CCCCCCCCCl 123-04-6 2-ETHYLHEXYLCHLORID C8H17Cl 148.67 CCCCC(CC)CCl 75-63-8 BROMTRIFLUORMETHAN CBrF3 148.91 FC(F)(F)Br 1119-51-3 5-BROM-1-PENTEN C5H9Br 149.03 BrCCCC=C

Page 67 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 137-43-9 BROMCYCLOPENTAN C5H9Br 149.03 BrC1CCCC1 532-54-7 isonitrosoacetophenone C8H7NO2 149.15 ON=CC(c1ccccc1)=O 597-09-1 2-ETHYL-2-NITRO-1,3-PROPANDIOL C5H11NO4 149.15 OCC(CO)(CC)N(=O)=O 700-00-5 9-METHYL-9H-PURIN-6-AMIN C6H7N5 149.15 Nc2ncnc1c2ncn1C 5142-23-4 3-METHYL-3H-PURIN-6-AMIN C6H7N5 149.15 Nc2c1ncnc1n(C)cn2 620-71-3 propionanilide C9H11NO 149.19 CCC(=O)Nc1ccccc1 537-92-8 n-(3-methylphenyl)-acetamide C9H11NO 149.19 Cc1cc(ccc1)NC(C)=O 103-89-9 P-METHYLACETANILID C9H11NO 149.19 Cc1ccc(cc1)NC(C)=O 120-66-1 O-METHYLACETANILID C9H11NO 149.19 Cc1ccccc1NC(C)=O 70-69-9 1-(4-aminophenyl)-1-propanone C9H11NO 149.19 CCC(=O)c(cc1)ccc1N 588-46-5 N-(PHENYLMETHYL)ACETAMID C9H11NO 149.19 CC(=O)NCc1ccccc1 100-10-7 4-DIMETHYLAMINOBENZALDEHYD C9H11NO 149.19 CN(C)c1ccc(C=O)cc1 579-10-2 N-METHYL-N-PHENYLACETAMID C9H11NO 149.19 CN(c1ccccc1)C(C)=O 611-74-5 N,N-DIMETHYLBENZAMID C9H11NO 149.19 CN(C)C(c1ccccc1)=O 102-71-6 TRIETHANOLAMIN C6H15NO3 149.19 OCCN(CCO)CCO 622-78-6 BENZYLISOTHIOCYANAT C8H7NS 149.21 S=C=NCc1ccccc1 3012-37-1 benzylthiocyanate C8H7NS 149.21 N#CSCc1ccccc1 120-75-2 2-METHYLBENZOTHIAZOL C8H7NS 149.21 Cc2sc1ccccc1n2 52-67-5 pencillamine C5H11NO2S 149.21 CC(C)(S)C(N)C(O)=O 622-59-3 4-methylphenylisothiocyanate C8H7NS 149.21 Cc1ccc(cc1)N=C=S 59-51-8 RS-METHIONINE C5H11NO2S 149.21 CSCCC([NH3+])C([O-])=O 579-66-8 2,6-DIETHYLBENZOLAMIN C10H15N 149.23 CCc1cccc(CC)c1N 1126-78-9 N-BUTYLBENZOLAMIN C10H15N 149.23 CCCCNc1ccccc1 104-13-2 4-BUTYLBENZOLAMIN C10H15N 149.23 CCCCc(cc1)ccc1N 769-92-6 4-(1,1-DIMETHYLETHYL)BENZOLAMIN C10H15N 149.23 CC(C)(C)c(cc1)ccc1N 102-97-6 n-(1-methylethyl)-benzenemethanamine C10H15N 149.23 CC(C)NCc1ccccc1 2294-76-0 2-PENTYLPYRIDIN C10H15N 149.23 CCCCCc1ccccn1 93-88-9 n,b-dimethylbenzeneethanamine C10H15N 149.23 CNCC(C)c1ccccc1 122-09-8 phentermine C10H15N 149.23 NC(C)(C)Cc1ccccc1 91-66-7 N,N-DIETHYLBENZOLAMIN C10H15N 149.23 CCN(CC)c1ccccc1 769-06-2 N,N,2,6-TETRAMETHYLBENZOLAMIN C10H15N 149.23 CN(C)c1c(C)cccc1C 115-20-8 2,2,2-TRICHLORETHANOL C2H3Cl3O 149.40 OCC(Cl)(Cl)Cl 75-79-6 TRICHLORMETHYLSILAN CH3Cl3Si 149.48 C[Si](Cl)(Cl)Cl 116-15-4 HEXAFLUORPROPEN C3F6 150.02 FC(F)(F)C(F)=C(F)F 422-05-9 2,2,3,3,3-PENTAFLUORPROPANOL C3H3F5O 150.05 OCC(F)(F)C(F)(F)F 1885-48-9 2-(DIFLUORMETHOXY)-1,1,1-TRIFLUORETHAN C3H3F5O 150.05 FC(F)OCC(F)(F)F 22410-44-2 METHYLPERFLUOROETHYLETHER(HFE245MC) C3H3F5O 150.05 COC(F)(F)C(F)(F)F 327-54-8 1,2,4,5-TETRAFLUORBENZOL C6H2F4 150.07 Fc1cc(F)c(F)cc1F 2367-82-0 1,2,3,5-TETRAFLUORBENZOL C6H2F4 150.07 Fc(cc1F)cc(F)c1F 551-62-2 1,2,3,4-TETRAFLUORBENZOL C6H2F4 150.07 Fc1ccc(F)c(F)c1F 1493-13-6 TRIFLUORMETHANSULFONSAEURE CHF3O3S 150.08 FC(F)(F)S(O)(=O)=O 133-37-9 DL-WEINSAEURE C4H6O6 150.09 OC(C(O)C(O)=O)C(O)=O 526-83-0 2,3-dihydroxybutanedioicacid C4H6O6 150.09 OC(C(O)C(O)=O)C(O)=O 611-73-4 ALPHA-OXOBENZOLESSIGSAEURE C8H6O3 150.13 OC(=O)C(c1ccccc1)=O 120-57-0 1,3-BENZODIOXOL-5-CARBOXALDEHYD C8H6O3 150.13 O=Cc2cc1OCOc1cc2 619-21-6 3-FORMYLBENZOESAEURE C8H6O3 150.13 OC(=O)c(ccc1)cc1C=O 619-66-9 4-FORMYLBENZOESAEURE C8H6O3 150.13 OC(=O)c(cc1)ccc1C=O 119-67-5 2-FORMYLBENZOESAEURE C8H6O3 150.13 OC(=O)c1ccccc1C=O 16528-92-0 1,3,5,7,9-PENTOXECAN C5H10O5 150.13 C1OCOCOCOCO1 25990-60-7 xylose C5H10O5 150.13 OCC(O)C(O)C(O)C=O 147-81-9 arabinose C5H10O5 150.13 OCC(O)C(O)C(O)C=O 19164-41-1 benzofurazan,5-methyl-,1-oxide C7H6N2O2 150.14 Cc(ccc1n2=O)cc1no2 4413-48-3 benzofurazan,5-methoxy- C7H6N2O2 150.14 COc2cc1nonc1cc2 1904-98-9 1h-purine-2,6-diamine C5H6N6 150.14 Nc2nc1[nH]cnc1c(N)n2 875-31-0 9-methylpoxanthine C6H6N4O 150.14 Cn1cnc2c1N=CNC2=O 70-49-5 DL-MERCAPTOBERNSTEINSAEURE C4H6O4S 150.15 SC(CC(O)=O)C(O)=O 123-93-3 2,2'-thiobisaceticacid C4H6O4S 150.15 OC(CSCC(O)=O)=O 112-27-6 2,2`-(1,2-ETHANDIYLBIS(OXY))BISETHANOL C6H14O4 150.17 OCCOCCOCCO 89-71-4 2-METHYLBENZOESAEUREMETHYLESTER C9H10O2 150.18 COC(=O)c1ccccc1C 93-89-0 BENZOESAEUREETHYLESTER C9H10O2 150.18 CCOC(=O)c1ccccc1 1450-72-2 1-(2-HYDROXY-5-METHYLPHENYL)ETHANON C9H10O2 150.18 CC(=O)c1cc(C)ccc1O 99-36-5 3-METHYLBENZOESAEUREMETHYLESTER C9H10O2 150.18 COC(=O)c(ccc1)cc1C

Page 68 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 611-01-8 2,4-DIMETHYLBENZOESAEURE C9H10O2 150.18 OC(=O)c1ccc(C)cc1C 99-75-2 4-METHYLBENZOESAEUREMETHYLESTER C9H10O2 150.18 COC(=O)c(cc1)ccc1C 610-72-0 2,5-DIMETHYLBENZOESAEURE C9H10O2 150.18 OC(=O)c1cc(C)ccc1C 499-06-9 3,5-DIMETHYLBENZOESAEURE C9H10O2 150.18 OC(=O)c(cc1C)cc(C)c1 637-27-4 PROPANSAEUREPHENYLESTER C9H10O2 150.18 CCC(=O)Oc1ccccc1 619-64-7 4-ETHYLBENZOESAEURE C9H10O2 150.18 CCc1ccc(C(O)=O)cc1 619-04-5 3,4-DIMETHYLBENZOESAEURE C9H10O2 150.18 OC(=O)c(ccc1C)cc1C 7775-38-4 BENZYLALCOHOL,ALPHA-METHYL-,FORMATE C9H10O2 150.18 CC(OC=O)c1ccccc1 122-46-3 ESSIGSAEURE-3-METHYLPHENYLESTER C9H10O2 150.18 CC(=O)Oc(ccc1)cc1C 140-39-6 ESSIGSAEURE-4-METHYLPHENYLESTER C9H10O2 150.18 CC(=O)Oc(cc1)ccc1C 619-20-5 3-ETHYLBENZOESAEURE C9H10O2 150.18 CCc1cc(C(O)=O)ccc1 122-60-1 2-PHENOXYMETHYLOXIRAN C9H10O2 150.18 C1OC1COc2ccccc2 533-18-6 2-METHYLPHENYLACETAT C9H10O2 150.18 CC(=O)Oc1ccccc1C 7786-61-0 4-ethenyl-2-methoxyphenol C9H10O2 150.18 COc1cc(C=C)ccc1O 603-79-2 2,3-DIMETHYLBENZOESAEURE C9H10O2 150.18 OC(=O)c(cccc1C)c1C 70-70-2 1-(4-HYDROXYPHENYL)-1-PROPANON C9H10O2 150.18 CCC(=O)c(cc1)ccc1O 612-19-1 2-ETHYLBENZOESAEURE C9H10O2 150.18 CCc1ccccc1C(O)=O 101-41-7 BENZOLESSIGSAEUREMETHYLESTER C9H10O2 150.18 COC(=O)Cc1ccccc1 622-47-9 4-METHYLPHENYLESSIGSAEURE C9H10O2 150.18 OC(=O)Cc(cc1)ccc1C 621-36-3 3-METHYLPHENYLESSIGSAEURE C9H10O2 150.18 OC(=O)Cc(ccc1)cc1C 140-11-4 ESSIGSAEUREPHENYLMETHYLESTER C9H10O2 150.18 CC(OCc1ccccc1)=O 501-52-0 BENZOLPROPANSAEURE C9H10O2 150.18 OC(CCc1ccccc1)=O 632-46-2 2,6-DIMETHYLBENZOESAEURE C9H10O2 150.18 OC(=O)c1c(C)cccc1C 613-69-4 2-ETHOXYBENZALDEHYD C9H10O2 150.18 CCOc1ccccc1C=O 586-37-8 1-(3-METHOXYPHENYL)ETHANON C9H10O2 150.18 COc1cc(C(C)=O)ccc1 621-87-4 1-phenoxy-2-propanone C9H10O2 150.18 CC(COc1ccccc1)=O 32974-92-8 1-(3-ethylpyrazin-2-yl)ethanone C8H10N2O 150.18 CCc1nccnc1C(C)=O 10031-82-0 4-ethoxybenzaldehyde C9H10O2 150.18 CCOc1ccc(C=O)cc1 100-06-1 1-(4-METHOXYPHENYL)ETHANON C9H10O2 150.18 COc1ccc(C(C)=O)cc1 1007-36-9 N-METHYL-N-PHENYLHARNSTOFF C8H10N2O 150.18 CNC(=O)Nc1ccccc1 4079-52-1 2-methoxy-1-phenylethanone C9H10O2 150.18 COCC(=O)c1ccccc1 63-99-0 m-tolylurea C8H10N2O 150.18 Cc1cc(ccc1)NC(=O)N 3619-22-5 p-methylbenzoylhydrazine C8H10N2O 150.18 Cc1ccc(cc1)C(=O)NN 138-89-6 N,N-DIMETHYL-4-NITROSOBENZOLAMIN C8H10N2O 150.18 CN(C)c1ccc(N=O)cc1 538-32-9 benzylurea C8H10N2O 150.18 O=C(N)NCc1ccccc1 122-80-5 N-(4-AMINOPHENYL)ACETAMID C8H10N2O 150.18 Nc1ccc(cc1)NC(C)=O 583-39-1 1,3-DIHYDRO-2H-BENZIMIDAZOL-2-THION C7H6N2S 150.20 Sc2[nH]c1ccccc1n2 533-30-2 6-benzothiazolamine C7H6N2S 150.20 Nc(ccc1n2)cc1sc2 136-95-8 2-aminobenzothiazole C7H6N2S 150.20 Nc2sc1ccccc1n2 3610-02-4 benzo(b)thiophene-4-ol C8H6OS 150.20 Oc1cccc2c1ccs2 611-69-8 isopropylbenzylalcohol C10H14O 150.22 CC(C)C(O)c1ccccc1 536-60-7 4-ISOPROPYLBENZYLALKOHOL C10H14O 150.22 OCc1ccc(C(C)C)cc1 527-35-5 2,3,5,6-TETRAMETHYLPHENOL C10H14O 150.22 Cc1cc(C)c(C)c(O)c1C 3238-38-8 2,3,4,6-TETRAMETHYLPHENOL C10H14O 150.22 Cc1cc(C)c(C)c(C)c1O 2344-70-9 ALPHA-METHYLBENZOLPROPANOL C10H14O 150.22 OC(C)CCc1ccccc1 100-86-7 ALPHA,ALPHA-DIMETHYLBENZOLETHANOL C10H14O 150.22 OC(C)(C)Cc1ccccc1 3228-04-4 2-METHYL-6-(1-METHYLETHYL)PHENOL C10H14O 150.22 CC(C)c(cccc1C)c1O 564-94-3 myrtenal C10H14O 150.22 CC1(C)C2CC1CC=C2C=O 488-70-0 2,3,4,5-TETRAMETHYLPHENOL C10H14O 150.22 Oc1cc(C)c(C)c(C)c1C 2111-75-3 perillaldehyde C10H14O 150.22 CC(C1CC=C(CC1)C=O)=C 3228-02-2 PHENOL,3-METHYL-4-(1-METHYLETHYL) C10H14O 150.22 CC(C)c1ccc(O)cc1C 3228-03-3 PHENOL,3-METHYL-5-(1-METHYLETHYL) C10H14O 150.22 CC(C)c(cc1O)cc(C)c1 4371-46-4 phenol,4-methyl-3-(1-methylethyl)- C10H14O 150.22 CC(C)c1cc(O)ccc1C 499-75-2 2-METHYL-5-(1-METHYLETHYL)PHENOL C10H14O 150.22 CC(C)c(ccc1C)cc1O 1638-22-8 4-BUTYLPHENOL C10H14O 150.22 CCCCc(cc1)ccc1O 4371-48-6 2-METHYL-3-(1-METHYLETHYL)PHENOL C10H14O 150.22 CC(C)c(cccc1O)c1C 99-71-8 4-(1-METHYLPROPYL)PHENOL C10H14O 150.22 CCC(C)c(cc1)ccc1O 116-26-7 2,6,6-trimethylcyclohexa-1,3-diene-1-carbaldehyde C10H14O 150.22 CC1(C)CC=CC(C)=C1C=O 98-54-4 4-TERT.-BUTYLPHENOL C10H14O 150.22 CC(C)(C)c(cc1)ccc1O 700-58-3 TRICYCLO(3.3.1.1(3,7))DECANON C10H14O 150.22 O=C2C3CC(C1)CC2CC1C3 89-83-8 5-METHYL-2-(1-METHYLETHYL)PHENOL C10H14O 150.22 CC(C)c1ccc(C)cc1O 3180-09-4 2-BUTYLPHENOL C10H14O 150.22 CCCCc1ccccc1O

Page 69 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 585-34-2 3-(1,1-DIMETHYLETHYL)PHENOL C10H14O 150.22 CC(C)(C)c(ccc1)cc1O 99-49-0 D(+)-CARVON C10H14O 150.22 CC(=C)C(CC=C1C)CC1=O 32736-91-7 2,5-diethyl-3-methylpyrazine C9H14N2 150.22 CCc(cnc1CC)nc1C 18138-04-0 pyrazine, 2,3-diethyl-5-methyl- C9H14N2 150.22 CCc1ncc(C)nc1CC 3228-01-1 3-METHYL-2-ISOPROPYLPHENOL C10H14O 150.22 CC(C)c1c(C)cccc1O 18138-05-1 3,5-diethyl-2-methylpyrazine C9H14N2 150.22 CCc(cnc1C)nc1CC 13925-06-9 2-methyl-3-(2-methylpropyl)pyrazine C9H14N2 150.22 CC(C)Cc1nccnc1C 491-09-8 3-methyl-6-propan-2-ylidenecyclohex-2-en-1-one C10H14O 150.22 CC(CCC1=C(C)C)=CC1=O 88-18-6 2-TERT.-BUTYLPHENOL C10H14O 150.22 CC(C)(C)c1ccccc1O 19177-04-9 BENZENE,1-METHYL-3-(1-METHYLETHOXY) C10H14O 150.22 CC(C)Oc(ccc1)cc1C 104-45-0 1-methoxy-4-propylbenzene C10H14O 150.22 CCCc(cc1)ccc1OC 1126-79-0 BUTYLPHENYLETHER C10H14O 150.22 CCCCOc1ccccc1 539-52-6 3-(4-methyl-3-pentenyl)furan C10H14O 150.22 CC(C)=CCCc1cocc1 1126-75-6 (2-METHYLPROPOXY)BENZOL C10H14O 150.22 CC(C)COc1ccccc1 15186-51-3 3-methyl-2-(3-methylbut-2-enyl)furan C10H14O 150.22 CC(C)=CCc1occc1C 494-90-6 4,5,6,7-tetrahydro-3,6-dimethylbenzofuran C10H14O 150.22 CC2Cc1c(CC2)occ1C 598-03-8 DIPROPYLSULFON C6H14O2S 150.24 CCCS(CCC)(=O)=O 34008-94-1 2-(ETHYLSULFONYL)-2-METHYLPROPAN C6H14O2S 150.24 CCS(C(C)(C)C)(=O)=O 6165-55-5 2,3-DIHYDRO-2-METHYL-BENZO(B)THIOPHENE C9H10S 150.24 CC2Sc1ccccc1C2 5314-55-6 ETHYLTRIMETHOXYSILAN C5H14O3Si 150.25 CO[Si](OC)(OC)CC 67952-60-7 2-methyl-2-methyldisulfanylpropanal C5H10OS2 150.26 CSSC(C)(C)C=O 623-80-3 s,s-diethylcarbonodithioate C5H10OS2 150.26 CCSC(SCC)=O 700-56-1 2-METHYLTRICYCLO(3.3.1.1(3,7))DECAN C11H18 150.26 CC2C(CC3C1)CC1CC2C3 768-91-2 1-METHYL-ADAMANTAN C11H18 150.26 CC2(CC3C1)CC(C3)CC1C2 1748-15-8 1,3-DITHIAN-2-THION C4H6S3 150.29 S=C1SCCCS1 768-32-1 TRIMETHYLPHENYLSILAN C9H14Si 150.29 C[Si](C)(C)c1ccccc1 1191-43-1 1,6-HEXANDITHIOL C6H14S2 150.31 SCCCCCCS 629-19-6 DIPROPYLDISULFID C6H14S2 150.31 CCCSSCCC 4151-69-3 ETHYL-(1,1-DIMETHYLETHYL)-DISULFID C6H14S2 150.31 CCSSC(C)(C)C 4253-89-8 BIS(1-METHYLETHYL)DISULFID C6H14S2 150.31 CC(C)SSC(C)C 107-59-5 chloroaceticacid-1,1-dimethylethylester C6H11ClO2 150.60 CC(C)(C)OC(CCl)=O 590-02-3 CHLORESSIGSAEUREBUTYLESTER C6H11ClO2 150.60 CCCCOC(CCl)=O 3153-36-4 4-CHLORBUTANSAEUREETHYLESTER C6H11ClO2 150.60 ClCCCC(OCC)=O 2344-83-4 (3-chloropropyl)-trimethylsilane C6H15ClSi 150.72 ClCCC[Si](C)(C)C 1000-50-6 silane,butylchlorodimethyl- C6H15ClSi 150.72 CCCC[Si](C)(C)Cl 994-30-9 CHLORTRIETHYLSILAN C6H15ClSi 150.72 CC[Si](Cl)(CC)CC 517-25-9 TRINITROMETHAN CHN3O6 151.04 O=N(=O)C(N(=O)=O)N(=O)=O 507-36-8 2-BROM-2-METHYLBUTAN C5H11Br 151.05 CCC(C)(C)Br 107-82-4 1-BROM-3-METHYLBUTAN C5H11Br 151.05 BrCCC(C)C 107-81-3 2-BROMPENTAN C5H11Br 151.05 CCCC(C)Br 110-53-2 1-PENTYLBROMID C5H11Br 151.05 CCCCCBr 630-17-1 1-BROM-2,2-DIMETHYLPROPAN C5H11Br 151.05 BrCC(C)(C)C 534-00-9 1-bromo-isobutane C5H11Br 151.05 CCC(C)CBr 1809-10-5 3-BROMPENTAN C5H11Br 151.05 CCC(Br)CC 2875-18-5 2,3,5,6-tetrafluoropyridine C5HF4N 151.06 Fc1nc(F)c(F)cc1F 552-89-6 2-NITROBENZALDEHYD C7H5NO3 151.12 O=Cc1ccccc1N(=O)=O 555-16-8 4-NITROBENZALDEHYD C7H5NO3 151.12 O=Cc1ccc(cc1)N(=O)=O 99-61-6 3-NITROBENZALDEHYD C7H5NO3 151.12 O=Cc1cc(ccc1)N(=O)=O 126-11-4 2-(HYDROXYMETHYL)-2-NITRO-1,3-PROPANDIOL C4H9NO5 151.12 OCC(CO)(CO)N(=O)=O 73-40-5 2-AMINO-1,7-DIHYDRO-6H-PURIN-6-ON C5H5N5O 151.13 O=C2NC(N)=Nc1[nH]cnc21 100-12-9 4-ETHYLNITROBENZOL C8H9NO2 151.16 CCc1ccc(cc1)N(=O)=O 99-51-4 3,4-DIMETHYLNITROBENZOL C8H9NO2 151.16 Cc1ccc(cc1C)N(=O)=O 89-87-2 1,3-DIMETHYL-4-NITROBENZOL C8H9NO2 151.16 Cc(ccc1N(=O)=O)cc1C 83-41-0 1,2-DIMETHYL-3-NITROBENZOL C8H9NO2 151.16 Cc1cccc(c1C)N(=O)=O 89-58-7 1,4-dimethyl-2-nitrobenzene C8H9NO2 151.16 Cc(ccc1C)cc1N(=O)=O 612-22-6 2-ETHYLNITROBENZOL C8H9NO2 151.16 CCc1ccccc1N(=O)=O 81-20-9 1,3-DIMETHYL-2-NITROBENZOL C8H9NO2 151.16 Cc1cccc(C)c1N(=O)=O 134-20-3 2-AMINOBENZOESAEUREMETHYLESTER C8H9NO2 151.16 COC(=O)c1ccccc1N 2603-10-3 METHYLPHENYLURETHAN C8H9NO2 151.16 COC(=O)Nc1ccccc1 1943-79-9 METHYLCARBAMIDSAEUREPHENYLESTER C8H9NO2 151.16 CNC(Oc1ccccc1)=O 614-80-2 o-hydroxyacetanilide C8H9NO2 151.16 Oc1ccccc1NC(C)=O 10541-83-0 4-methylaminobenzoicacid C8H9NO2 151.16 CNc1ccc(C(O)=O)cc1

Page 70 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 119-68-6 2-(methylamino)benzoicacid C8H9NO2 151.16 CNc1ccccc1C(O)=O 619-45-4 4-AMINOBENZOESAEUREMETHYLESTER C8H9NO2 151.16 COC(=O)c(cc1)ccc1N 621-84-1 o-benzylcarbamate C8H9NO2 151.16 O=C(OCc1ccccc1)N 103-01-5 N-PHENYLGLYCIN C8H9NO2 151.16 OC(CNc1ccccc1)=O 621-42-1 m-hydroxyacetanilide C8H9NO2 151.16 Oc1cc(ccc1)NC(C)=O 2486-70-6 4-AMINO-3-METHYLBENZOICACID C8H9NO2 151.16 OC(=O)c(ccc1N)cc1C 103-90-2 N-(4-HYDROXYPHENYL)ACETAMID C8H9NO2 151.16 Oc1ccc(cc1)NC(C)=O 614-18-6 3-PYRIDINCARBONSAEUREETHYLESTER C8H9NO2 151.16 CCOC(=O)c1cccnc1 1570-45-2 4-PYRIDINCARBONSAEUREETHYLESTER C8H9NO2 151.16 CCOC(=O)c1ccncc1 621-88-5 PHENOXYACETAMID C8H9NO2 151.16 O=C(COc1ccccc1)N 2524-52-9 2-PYRIDINCARBONSAEUREETHYLESTER C8H9NO2 151.16 CCOC(=O)c1ccccn1 1197-55-3 P-AMINOPHENYLACETICACID C8H9NO2 151.16 OC(=O)Cc(cc1)ccc1N 3424-93-9 4-METHOXYBENZAMID C8H9NO2 151.16 COc1ccc(cc1)C(=O)N 69-91-0 alpha-aminobenzeneaceticacid C8H9NO2 151.16 [NH3+]C(c1ccccc1)C([O-])=O 537-47-3 n-phenylhydrazinecarboxamide C7H9N3O 151.17 NNC(=O)Nc1ccccc1 103-03-7 2-phenylhydrazinecarboxamide C7H9N3O 151.17 O=C(N)NNc1ccccc1 934-34-9 s-orthophenylenethiocarbamate C7H5NOS 151.19 O=C2Nc1ccccc1S2 1518-86-1 4-(2-aminopropyl)phenol C9H13NO 151.21 NC(C)Cc(cc1)ccc1O 700-75-4 2-METHOXY-N,N-DIMETHYLBENZOLAMIN C9H13NO 151.21 COc1ccccc1N(C)C 136-80-1 2-(2-methylphenyl)aminoethanol C9H13NO 151.21 OCCNc1ccccc1C 1703-46-4 4-(dimethylamino)benzenemethanol C9H13NO 151.21 OCc1ccc(N(C)C)cc1 13044-92-3 n,n-dimethylamino-2,4,6-heptatriene-7al C9H13NO 151.21 CN(C)C=CC=CC=CC=O 637-53-6 thioacetanilide C8H9NS 151.23 CC(=S)Nc1ccccc1 768-94-5 TRICYCLO(3.3.1.1(3,7))DECAN-1-AMIN C10H17N 151.25 NC1(CC2C3)CC(C2)CC3C1 13818-89-8 DIGERMAN H6Ge2 151.33 [GeH3][GeH3] 359-28-4 1,1,2-TRICHLOR-2-FLUORETHAN C2H2Cl3F 151.40 FC(Cl)C(Cl)Cl 2366-36-1 1,1,1-TRICHLOR-2-FLUORETHAN_(F-131B) C2H2Cl3F 151.40 FCC(Cl)(Cl)Cl 431-63-0 1,1,1,2,3,3-HEXAFLUORPROPAN C3H2F6 152.04 FC(F)C(F)C(F)(F)F 690-39-1 1,1,1,3,3,3-HEXAFLUORPROPAN C3H2F6 152.04 FC(F)(F)CC(F)(F)F 628-96-6 ETHYLENGLYKOLDINITRAT C2H4N2O6 152.06 O=N(OCCON(=O)=O)=O 612-29-3 1-nitro-2-nitrosobenzene C6H4N2O3 152.11 O=Nc1ccccc1N(=O)=O 17122-21-3 benzene,1-nitro-3-nitroso- C6H4N2O3 152.11 O=Nc1cc(ccc1)N(=O)=O 683-08-9 METHYLPHOSPHONSAEUREDIETHYLESTER C5H13O3P 152.13 CCOP(C)(OCC)=O 119-36-8 2-HYDROXYBENZOESAEUREMETHYLESTER C8H8O3 152.15 COC(=O)c1ccccc1O 935-79-5 (3AR,7AS)-REL-3A,4,7,7A-TETRAHYDRO-1,3-ISOBENZOFURANDIONC8H8O3 152.15 O=C2OC(C1CC=CCC21)=O 4208-49-5 2-furancarboxylicacid-2-propenylester C8H8O3 152.15 C=CCOC(=O)c1occc1 673-22-3 2-HYDROXY-4-METHOXYBENZALDEHYD C8H8O3 152.15 COc(ccc1C=O)cc1O 612-28-2 n-methyl-o-nitroaniline C7H8N2O2 152.15 CNc1ccccc1N(=O)=O 100-09-4 4-METHOXYBENZOESAEURE C8H8O3 152.15 COc1ccc(C(O)=O)cc1 99-76-3 4-HYDROXYBENZOESAEUREMETHYLESTER C8H8O3 152.15 COC(=O)c(cc1)ccc1O 148-53-8 2-HYDROXY-3-METHOXY-BENZALDEHYD C8H8O3 152.15 COc1cccc(C=O)c1O 570-24-1 2-METHYL-6-NITROBENZOLAMIN C7H8N2O2 152.15 Cc1cccc(c1N)N(=O)=O 121-33-5 3-METHOXY-4-HYDROXYBENZALDEHYD C8H8O3 152.15 COc1cc(C=O)ccc1O 586-38-9 3-METHOXYBENZOESAEURE C8H8O3 152.15 COc1cc(C(O)=O)ccc1 495-76-1 1,3-BENZODIOXOL-5-METHANOL C8H8O3 152.15 OCc2cc1OCOc1cc2 3006-96-0 4-HYDROXYMETHYL-BENZOICACID C8H8O3 152.15 OCc1ccc(C(O)=O)cc1 603-83-8 3-nitro-o-toluidine C7H8N2O2 152.15 Nc1cccc(c1C)N(=O)=O 99-55-8 2-METHYL-5-NITROBENZOLAMIN C7H8N2O2 152.15 Cc1ccc(cc1N)N(=O)=O 96937-45-0 4-hydroxymethylbenzoicacid C8H8O3 152.15 OCc1ccc(C(O)=O)cc1 89-62-3 4-METHYL-2-NITROBENZOLAMIN C7H8N2O2 152.15 Cc(ccc1N)cc1N(=O)=O 621-59-0 isovanillin C8H8O3 152.15 COc1ccc(C=O)cc1O 89-84-9 1-(2,4-dihydroxyphenyl)ethanone C8H8O3 152.15 CC(=O)c1ccc(O)cc1O 28631-86-9 2,2-dihydroxy-1-phenylethanone C8H8O3 152.15 OC(O)C(=O)c1ccccc1 119-32-4 4-METHYL-3-NITROBENZOLAMIN C7H8N2O2 152.15 Nc(ccc1C)cc1N(=O)=O 102-29-4 m-hydroxyphenylacetate C8H8O3 152.15 CC(=O)Oc(ccc1)cc1O 614-75-5 o-hydroxyphenylaceticacid C8H8O3 152.15 OC(=O)Cc1ccccc1O 50-85-1 2-HYDROXY-4-METHYLBENZOESAEURE C8H8O3 152.15 OC(=O)c1ccc(C)cc1O 122-59-8 PHENOXYESSIGSAEURE C8H8O3 152.15 OC(COc1ccccc1)=O 89-56-5 2-HYDROXY-5-METHYLBENZOESAEURE C8H8O3 152.15 OC(=O)c1cc(C)ccc1O 90-64-2 alpha-hydroxyphenylaceticacid C8H8O3 152.15 OC(C(O)=O)c1ccccc1 100-15-2 N-METHYL-4-NITROBENZOLAMIN C7H8N2O2 152.15 CNc1ccc(cc1)N(=O)=O 579-75-9 2-METHOXYBENZOESAEURE C8H8O3 152.15 COc1ccccc1C(O)=O

Page 71 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 83-40-9 2-HYDROXY-3-METHYLBENZOESAEURE C8H8O3 152.15 OC(=O)c(cccc1C)c1O 99-52-5 4-nitro-2-toluidine C7H8N2O2 152.15 Nc1ccc(cc1C)N(=O)=O 936-02-7 o-hydroxybenzoylhydrazine C7H8N2O2 152.15 Oc1ccccc1C(=O)NN 621-37-4 m-hydroxyphenylaceticacid C8H8O3 152.15 OC(=O)Cc(ccc1)cc1O 156-38-7 P-HYDROXYPHENYLESSIGSAEURE C8H8O3 152.15 OC(=O)Cc(cc1)ccc1O 611-03-0 2,4-diaminobenzoicacid C7H8N2O2 152.15 OC(=O)c1ccc(N)cc1N 619-05-6 3,4-diaminobenzoicacid C7H8N2O2 152.15 OC(=O)c(ccc1N)cc1N 535-87-5 3,5-DIAMINOBENZOESAEURE C7H8N2O2 152.15 OC(=O)c(cc1N)cc(N)c1 87-99-0 XYLITOL C5H12O5 152.15 OCC(O)C(O)C(O)CO 488-82-4 d-arabinitol C5H12O5 152.15 OCC(O)C(O)C(O)CO 4179-19-5 1,3-DIMETHOXY-5-METHYLBENZOL C9H12O2 152.19 COc(c1)cc(OC)cc1C 4812-20-8 o-i-propoxyphenol0 C9H12O2 152.19 CC(C)Oc1ccccc1O 20920-83-6 2-(ethoxymethyl)phenol C9H12O2 152.19 CCOCc1ccccc1O 2785-89-9 4-ethyl-2-methoxyphenol C9H12O2 152.19 CCc(ccc1O)cc1OC 80-15-9 1-METHYL-1-PHENYLETHYLHYDROPEROXID C9H12O2 152.19 OOC(C)(C)c1ccccc1 3194-17-0 1-furan-2-ylpentan-1-one C9H12O2 152.19 CCCCC(=O)c1occc1 60956-33-4 3-PHENYLPROPYLHYDROPEROXIDE C9H12O2 152.19 OOCCCc1ccccc1 4169-04-4 propyleneglycolmonophenylether C9H12O2 152.19 OCC(C)Oc1ccccc1 494-99-5 1,2-dimethoxy-4-methylbenzene C9H12O2 152.19 COc1ccc(C)cc1OC 770-35-4 1-PHENOXY-2-PROPANOL C9H12O2 152.19 OC(C)COc1ccccc1 41532-81-4 2-methoxyethoxybenzene0 C9H12O2 152.19 COCCOc1ccccc1 622-08-2 2-(PHENYLMETHOXY)ETHANOL C9H12O2 152.19 OCCOCc1ccccc1 16533-50-9 m-propoxyphenol C9H12O2 152.19 CCCOc(ccc1)cc1O 1125-21-9 4-OXOISOPHORON C9H12O2 152.19 CC1(C)CC(=O)C=C(C)C1=O 700-13-0 2,3,5-TRIMETHYL-1,4-BENZOLDIOL C9H12O2 152.19 Oc(cc1C)c(C)c(C)c1O 1197-37-1 4-ethoxy-1,2-benzenediamine C8H12N2O 152.19 CCOc(ccc1N)cc1N 2138-43-4 4-isopropylcatechol C9H12O2 152.19 CC(C)c(ccc1O)cc1O 2138-48-9 3-(1-METHYLETHYL)-1,2-BENZOLDIOL C9H12O2 152.19 CC(C)c(cccc1O)c1O 208-96-8 ACENAPHTHYLEN C12H8 152.19 C(=Cc2c1c3ccc2)c1ccc3 259-79-0 DIPHENYLEN C12H8 152.19 c3cc1c2ccccc2c1cc3 681-84-5 KIESELSAEURE(H4SIO4)TETRAMETHYLESTER C4H12O4Si 152.22 CO[Si](OC)(OC)OC 103-85-5 PHENYLTHIOHARNSTOFF C7H8N2S 152.22 NC(=S)Nc1ccccc1 36267-71-7 2-methyl-5,7-dihydrothieno[3,4-d]pyrimidine C7H8N2S 152.22 Cc(ncc1C2)nc1CS2 473-67-6 4,7,7-trimethylbicyclo[3.1.1]hept-3-en-2-ol C10H16O 152.23 CC1(C)C2CC1C(O)C=C2C 5947-36-4 7,7-dimethyl-4-methylidenebicyclo[3.1.1]heptan-3-ol C10H16O 152.23 CC1(C)C(CC1CC2O)C2=C 13679-86-2 2-ethenyl-2-methyl-5-prop-1-en-2-yloxolane C10H16O 152.23 CC1(OC(CC1)C(C)=C)C=C 768-95-6 TRICYCLO(3.3.1.1(3,7))DECAN-1-OL C10H16O 152.23 OC2(CC3C1)CC(C3)CC1C2 536-59-4 4-(1-methylethenyl)-1-cyclohexene-1-methanol C10H16O 152.23 OCC(CC1)=CCC1C(C)=C 515-00-4 (7,7-dimethyl-4-bicyclo[3.1.1]hept-3-enyl)methanol C10H16O 152.23 CC1(C)C2CC1CC=C2CO 99-48-9 2-methyl-5-(1-methylethenyl)-2-cyclohexen-1-ol C10H16O 152.23 OC1CC(CC=C1C)C(C)=C 55253-28-6 (1r,2r,5s)-2-methyl-5-prop-1-en-2-ylcyclopentane-1-carbaldehydeC10H16O 152.23 CC1CCC(C1C=O)C(C)=C 546-80-5 (1S-(1ALPHA,4ALPHA,5ALPHA))-4-METHYL-1-(1-METHYLETHYL)BICYCLO(3.1.0)HEXAN-3-ONC10H16O 152.23 CC(C)C1(CC1C2C)CC2=O 1195-79-5 1,3,3-TRIMETHYLBICYCLO(2.2.1)HEPTAN-2-ON C10H16O 152.23 CC2(C)C(C1(C)CC2CC1)=O 4884-24-6 2-cyclopentylcyclopentan-1-one C10H16O 152.23 O=C2CCCC2C1CCCC1 51608-18-5 2-[(e)-pent-2-enyl]cyclopentan-1-one C10H16O 152.23 CCC=CCC1CCCC1=O 43219-68-7 1-(1,4-dimethyl-1-cyclohex-3-enyl)ethanone C10H16O 152.23 CC1(CC=C(C)CC1)C(C)=O 29606-79-9 5-methyl-2-prop-1-en-2-ylcyclohexan-1-one C10H16O 152.23 CC(CCC1C(C)=C)CC1=O 76-22-2 1,7,7-TRIMETHYLBICYCLO(2.2.1)HEPTAN-2-ON C10H16O 152.23 CC1(C)C(CCC21C)CC2=O 13351-29-6 (3AR,7AS)-REL-OCTAHYDRO-3A-METHYL-2H-INDEN-2-ON C10H16O 152.23 CC21CC(CC1CCCC2)=O 1786-08-9 4-methyl-2-(2-methylprop-1-enyl)-3,6-dihydro-2h-pyran C10H16O 152.23 CC(C)=CC1CC(C)=CCO1 13854-85-8 bicyclo[2.2.1]heptan-2-one,4,7,7-trimethyl-,(1r) C10H16O 152.23 CC1(CCC2C1(C)C)CC2=O 89-82-7 P-MENTH-4-(8)-EN-3-ON C10H16O 152.23 CC(CCC1=C(C)C)CC1=O 25152-84-5 TRANS,TRANS-2,4-DECADIENAL C10H16O 152.23 CCCCCC=CC=CC=O 5392-40-5 3,7-DIMETHYL-2,6-OCTADIENAL C10H16O 152.23 CC(C)=CCCC(C)=CC=O 89-81-6 3-METHYL-6-(1-METHYLETHYL)-2-CYCLOHEXEN-1-ON C10H16O 152.23 CC(C)C1CCC(C)=CC1=O 3720-16-9 3-methyl-5-propylcyclohex-2-en-1-one C10H16O 152.23 CCCC1CC(=O)C=C(C)C1 700-57-2 TRICYCLO(3.3.1.1(3,7))DECAN-2-OL C10H16O 152.23 OC3C(CC2C1)CC1CC3C2 40018-26-6 1,4-dithiane-2,5-diol C4H8O2S2 152.24 OC1CSC(O)CS1 2273-41-8 ALPHA,ALPHA-DIMETHYLPRIPERIDINACETONITRIL C9H16N2 152.24 CC(C)(N1CCCCC1)C#N 3019-20-3 (ISOPROPYLTHIO)-BENZOL C9H12S 152.26 CC(C)Sc1ccccc1 622-63-9 1-(ETHYLTHIO)-4-METHYLBENZOL C9H12S 152.26 CCSc(cc1)ccc1C 874-79-3 PHENYLPROPYLSULFID C9H12S 152.26 CCCSc1ccccc1

Page 72 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 2243-98-3 1-UNDECIN C11H20 152.28 CCCCCCCCCC#C 2294-72-6 5-UNDECIN C11H20 152.28 CCCCCC#CCCCC 180-43-8 SPIRO[5.5]UNDECAN C11H20 152.28 C(CC1)CCC21CCCCC2 29415-95-0 BICYCLO[3.3.3]UNDECAN C11H20 152.28 C(C1)CC2CCCC1CCC2 34135-85-8 3-methylsulfanyldisulfanylprop-1-ene C4H8S3 152.30 CSSSCC=C 621-62-5 CHLORACETALDEHYDDIETHYLACETAL C6H13ClO2 152.62 CCOC(CCl)OCC 506-78-5 CYANIODID CIN 152.92 IC#N 306-83-2 2,2-DICHLOR-1,1,1-TRIFLUORETHAN C2HCl2F3 152.93 ClC(Cl)C(F)(F)F 354-23-4 1,2-DICHLOR-1,2,2-TRIFLUORETHAN C2HCl2F3 152.93 FC(Cl)C(F)(F)Cl 812-04-4 ETHANE,1,1-DICHLORO-1,2,2-TRIFLUORO- C2HCl2F3 152.93 FC(F)C(F)(Cl)Cl 627-63-4 (2E)-2-BUTENDIOYLDICHLORID C4H2Cl2O2 152.96 ClC(=O)C=CC(Cl)=O 96-32-2 BROMESSIGSAEUREMETHYLESTER C3H5BrO2 152.98 COC(CBr)=O 590-92-1 3-BROMPROPANSAEURE C3H5BrO2 152.98 BrCCC(O)=O 598-72-1 2-BROMPROPANSAEURE C3H5BrO2 152.98 CC(Br)C(O)=O 592-55-2 1-BROM-2-ETHOXYETHAN C4H9BrO 153.02 CCOCCBr 3172-52-9 2,5-DICHLORTHIOPHEN C4H2Cl2S 153.03 Clc1sc(Cl)cc1 2108-92-1 1,1-DICHLORCYCLOHEXAN C6H10Cl2 153.05 ClC1(Cl)CCCCC1 119-33-5 4-methyl-2-nitrophenol C7H7NO3 153.14 Cc(ccc1O)cc1N(=O)=O 555-03-3 1-METHOXY-3-NITROBENZOL C7H7NO3 153.14 COc1cc(ccc1)N(=O)=O 700-38-9 5-METHYL-2-NITROPHENOL C7H7NO3 153.14 Cc(ccc1N(=O)=O)cc1O 100-17-4 1-METHOXY-4-NITROBENZOL C7H7NO3 153.14 COc1ccc(cc1)N(=O)=O 91-23-6 1-METHOXY-2-NITROBENZOL C7H7NO3 153.14 COc1ccccc1N(=O)=O 619-25-0 m-nitrobenzylalcohol C7H7NO3 153.14 OCc1cc(ccc1)N(=O)=O 612-25-9 2-nitrobenzylalcohol C7H7NO3 153.14 OCc1ccccc1N(=O)=O 619-73-8 4-NITROBENZOLMETHANOL C7H7NO3 153.14 OCc1ccc(cc1)N(=O)=O 89-73-6 salicylhydroxamicacid C7H7NO3 153.14 Oc1ccccc1C(=O)NO 89-57-6 5-amino-2-hydroxybenzoicacid C7H7NO3 153.14 OC(=O)c1cc(N)ccc1O 2581-34-2 3-METHYL-4-NITROPHENOL C7H7NO3 153.14 Oc(ccc1N(=O)=O)cc1C 99-53-6 2-methyl-4-nitrophenol C7H7NO3 153.14 Oc1ccc(cc1C)N(=O)=O 3694-52-8 3-nitro-o-phenylenediamine C6H7N3O2 153.14 Nc1cccc(c1N)N(=O)=O 2374-03-0 3-hydroxy-4-aminobenzoicacid C7H7NO3 153.14 OC(=O)c(ccc1N)cc1O 100-16-3 (4-nitrophenyl)hydrazine C6H7N3O2 153.14 NNc1ccc(cc1)N(=O)=O 99-56-9 2-amino-4-nitroaniline C6H7N3O2 153.14 Nc1ccc(cc1N)N(=O)=O 351-28-0 N-(3-FLUORPHENYL)ACETAMID C8H8FNO 153.15 Fc1cc(ccc1)NC(C)=O 399-31-5 2-fluoroacetanilide C8H8FNO 153.15 Fc1ccccc1NC(C)=O 351-83-7 N-(4-FLUORPHENYL)ACETAMID C8H8FNO 153.15 Fc1ccc(cc1)NC(C)=O 86-53-3 1-NAPHTHALINCARBONITRIL C11H7N 153.18 N#Cc2c1ccccc1ccc2 51-61-6 4-(2-AMINOETHYL)-1,2-BENZOLDIOL C8H11NO2 153.18 NCCc(ccc1O)cc1O 613-46-7 2-NAPHTHALINCARBONITRIL C11H7N 153.18 N#Cc2cc1ccccc1cc2 102-56-7 2,5-DIMETHOXYBENZOLAMIN C8H11NO2 153.18 COc(ccc1OC)cc1N 404-72-8 1-fluoro-3-isothiocyanatobenzene C7H4FNS 153.18 Fc1cc(ccc1)N=C=S 999999-99-9 (z)-diethylstilbestrol_c0 C9H17N2 153.25 CCCC[N+](C=CN1C)=C1C 1975-78-6 DECANNITRIL C10H19N 153.27 CCCCCCCCCC#N 10025-87-3 PHOSPHOROXIDCHLORID Cl3OP 153.33 ClP(Cl)(Cl)=O 615-18-9 2-chlorobenzoxazole C7H4ClNO 153.57 Clc2oc1ccccc1n2 104-12-1 4-CHLORPHENYLISOCYANAT C7H4ClNO 153.57 Clc1ccc(cc1)N=C=O 2909-38-8 1-CHLOR-3-ISOCYANATOBENZOL C7H4ClNO 153.57 Clc1cc(ccc1)N=C=O 3320-83-0 1-CHLOR-2-ISOCYANATOBENZOL C7H4ClNO 153.57 Clc1ccccc1N=C=O 56-23-5 TETRACHLORMETHAN CCl4 153.82 ClC(Cl)(Cl)Cl 593-66-8 VINYLIODID C2H3I 153.95 IC=C 17003-75-7 2-FLUOR-2,2-DINITROETHANOL C2H3FN2O5 154.05 OCC(F)(N(=O)=O)N(=O)=O 598-02-7 phosphoricaciddiethylester C4H11O4P 154.10 CCOP(O)(OCC)=O 119-34-6 4-amino-2-nitrophenol C6H6N2O3 154.12 Nc(ccc1O)cc1N(=O)=O 303-07-1 2,6-DIHYDROXYBENZOESAEURE C7H6O4 154.12 OC(=O)c1c(O)cccc1O 490-79-9 2,5-DIHYDROXYBENZOESAEURE C7H6O4 154.12 OC(=O)c1cc(O)ccc1O 603-85-0 2-amino-3-nitrophenol C6H6N2O3 154.12 Oc1cccc(c1N)N(=O)=O 99-50-3 3,4-DIHYDROXYBENZOESAEURE C7H6O4 154.12 OC(=O)c(ccc1O)cc1O 303-38-8 2,3-DIHYDROXYBENZOESAEURE C7H6O4 154.12 OC(=O)c(cccc1O)c1O 89-86-1 .BETA.-RESORCYLSAEURE C7H6O4 154.12 OC(=O)c1ccc(O)cc1O 99-10-5 .ALPHA.-RESORCYLICACID C7H6O4 154.12 OC(=O)c(cc1O)cc(O)c1 99-57-0 2-amino-4-nitrophenol C6H6N2O3 154.12 Oc1ccc(cc1N)N(=O)=O 149-29-1 patulin C7H6O4 154.12 OC2C1=CC(OC1=CCO2)=O

Page 73 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 701-83-7 3-fluorophenylacetate C8H7FO2 154.14 CC(=O)Oc(ccc1)cc1F 405-50-5 p-fluorophenylaceticacid C8H7FO2 154.14 OC(=O)Cc(cc1)ccc1F 331-25-9 m-fluorophenylaceticacid C8H7FO2 154.14 OC(=O)Cc(ccc1)cc1F 451-82-1 o-fluorophenylaceticacid C8H7FO2 154.14 OC(=O)Cc1ccccc1F 656-31-5 2-fluorophenylurea C7H7FN2O 154.14 Fc1ccccc1NC(=O)N 770-19-4 (3-fluorophenyl)urea C7H7FN2O 154.14 Fc1cc(ccc1)NC(=O)N 659-30-3 (4-fluorophenyl)urea C7H7FN2O 154.14 Fc1ccc(cc1)NC(=O)N 13149-00-3 (3AR,7AS)-REL-HEXAHYDRO-1,3-ISOBENZOFURANDION C8H10O3 154.16 O=C2OC(C1CCCCC21)=O 615-10-1 3-furancarboxylicacidpropylester C8H10O3 154.16 CCCOC(=O)c1cocc1 623-19-8 2-furanmethanolpropanoate C8H10O3 154.16 CCC(OCc1occc1)=O 760-93-0 methacrylicanhydride C8H10O3 154.16 CC(=C)C(OC(=O)C(C)=C)=O 498-00-0 4-hydroxy-3-methoxy-benzylalkohol C8H10O3 154.16 OCc(ccc1O)cc1OC 91-10-1 2,6-DIMETHOXYPHENOL C8H10O3 154.16 COc1cccc(OC)c1O 623-68-7 2-butenoicacidanhydride C8H10O3 154.16 CC=CC(OC(=O)C=CC)=O 500-99-2 3,5-dimethoxyphenol C8H10O3 154.16 COc(c1)cc(OC)cc1O 1436-43-7 2-CHINOLINCARBONITRIL C10H6N2 154.17 N#Cc2nc1ccccc1cc2 2700-22-3 benzalmalononitrile C10H6N2 154.17 N#CC(=Cc1ccccc1)C#N 2973-27-5 4-cyanoquinoline C10H6N2 154.17 N#Cc2c1ccccc1ncc2 4401-71-2 1,3,5-TRIMETHYL-2,4(1H,3H)-PYRIMIDINDION C7H10N2O2 154.17 Cc1cn(C)c(=O)n(C)c1=O 13509-52-9 1,3,6-TRIMETHYL-2,4(1H,3H)-PYRIMIDINDION C7H10N2O2 154.17 Cc1cc(=O)n(C)c(=O)n1C 64-67-5 DIETHYLSULFAT C4H10O4S 154.19 CCOS(OCC)(=O)=O 147-93-3 2-mercaptobenzoicacid C7H6O2S 154.19 OC(=O)c1ccccc1S 15507-13-8 SULFURICACID,MONOBUTYL-ESTER C4H10O4S 154.19 CCCCOS(O)(=O)=O 7403-22-7 1-PENTALENECARBOXYLICACID,OCTAHYDRO C9H14O2 154.21 OC(C2C1CCCC1CC2)=O 1846-70-4 2-nonynoicacid C9H14O2 154.21 CCCCCCC#CC(O)=O 4430-31-3 3,4,4a,5,6,7,8,8a-octahydrochromen-2-one C9H14O2 154.21 O=C2OC1CCCCC1CC2 827-54-3 2-ethenylnaphthalene C12H10 154.21 C=Cc2cc1ccccc1cc2 92-52-4 BIPHENYL C12H10 154.21 c(cc1)ccc1c2ccccc2 83-32-9 1,2-DIHYDROACENAPHTHYLEN C12H10 154.21 C(Cc2c1c3ccc2)c1ccc3 72987-62-3 2-ethyl-3-methylsulfanylpyrazine C7H10N2S 154.23 CCc1nccnc1SC 2530-10-1 1-(2,5-DIMETHYL-3-THIENYL)ETHANON C8H10OS 154.23 CC(=O)c1cc(C)sc1C 18409-21-7 (2e,4e)-deca-2,4-dien-1-ol C10H18O 154.25 CCCCCC=CC=CCO 619-01-2 P-MENTH-8-EN-2-OL C10H18O 154.25 CC1CCC(CC1O)C(C)=C 562-74-3 4-methyl-1-(1-methylethyl)-3-cyclohexen-1-ol C10H18O 154.25 CC(C)C1(O)CC=C(C)CC1 138-87-4 1-METHYL-4-(1-METHYLETHENYL)CYCLOHEXANOL C10H18O 154.25 OC1(C)CCC(CC1)C(C)=C 98-55-5 ALPHA,ALPHA,4-TRIMETHYL-3-CYCLOHEXEN-1-METHANOLC10H18O 154.25 OC(C)(C)C1CC=C(C)CC1 586-82-3 1-METHYL-4-(1-METHYLETHYL)-3-CYCLOHEXEN-1-OL C10H18O 154.25 OC1(C)CC=C(CC1)C(C)C 491-04-3 3-methyl-6-propan-2-ylcyclohex-2-en-1-ol C10H18O 154.25 CC(C)C1CCC(C)=CC1O 18479-68-0 2-(4-methyl-1-cyclohex-3-enyl)propan-1-ol C10H18O 154.25 OCC(C)C1CC=C(C)CC1 38748-97-9 alpha-caran-3-ol C10H18O 154.25 OC2(C)CC(C1CC2)C1(C)C 78-70-6 LINALOOL C10H18O 154.25 OC(C)(CCC=C(C)C)C=C 39770-05-3 dec-9-enal C10H18O 154.25 O=CCCCCCCCC=C 470-67-7 1-METHYL-4-(1-METHYLETHYL)-7-OXABICYCLO(2.2.1)HEPTANC10H18O 154.25 CC(C)C2(CC1)OC1(C)CC2 89-79-2 2-ISOPROPENYL-5-METHYLCYCLOHEXANOL C10H18O 154.25 CC(CCC1C(C)=C)CC1O 106-25-2 NEROL C10H18O 154.25 OCC=C(C)CCC=C(C)C 1502-06-3 CYCLODECANON C10H18O 154.25 O=C1CCCCCCCCC1 14765-30-1 2-butan-2-ylcyclohexan-1-one C10H18O 154.25 CCC(C)C1CCCCC1=O 3913-71-1 2-decenal C10H18O 154.25 CCCCCCCC=CC=O 1074-95-9 5-methyl-2-(1-methylethyl)-cyclohexanone C10H18O 154.25 CC(CCC1C(C)C)CC1=O 499-70-7 2-methyl-5-propan-2-ylcyclohexan-1-one C10H18O 154.25 CC(C)C(CCC1C)CC1=O 470-82-6 1,3,3-TRIMETHYL-2-OXYBICYCLO(2.2.2)OCTAN C10H18O 154.25 CC2(CCC1CC2)OC1(C)C 16409-43-1 4-methyl-2-(2-methylprop-1-enyl)oxane C10H18O 154.25 CC1CC(OCC1)C=C(C)C 3483-12-3 DITHIOTHREITOL C4H10O2S2 154.25 SCC(O)C(O)CS 6627-72-1 DL-BORNEOL C10H18O 154.25 OC2CC(CCC21C)C1(C)C 124-76-5 EXO-1,7,7-TRIMETHYLBICYCLO(2.2.1)HEPTAN-2-OL C10H18O 154.25 OC2CC(CCC21C)C1(C)C 454-57-9 FLUORDIMETHYLPHENYLSILAN C8H11FSi 154.26 F[Si](C)(C)c1ccccc1 4861-58-9 2-PENTYLTHIOPHEN C9H14S 154.27 CCCCCc1sccc1 821-95-4 1-UNDECEN C11H22 154.29 CCCCCCCCCC=C 764-96-5 (5Z)-5-UNDECEN C11H22 154.29 CCCCCC=CCCCC 764-97-6 (5E)-5-UNDECEN C11H22 154.29 CCCCCC=CCCCC 4457-00-5 HEXYLCYCLOPENTAN C11H22 154.29 CCCCCCC1CCCC1 4292-92-6 PENTYLCYCLOHEXAN C11H22 154.29 CCCCCC1CCCCC1

Page 74 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 17619-36-2 1-methylsulfanyldisulfanylpropane C4H10S3 154.32 CCCSSSC 3600-24-6 DIETHYLTRISULFID C4H10S3 154.32 CCSSSCC 76-15-3 CHLORPENTAFLUORETHAN C2ClF5 154.47 FC(F)(F)C(F)(F)Cl 532-27-4 ALPHA-CHLORACETOPHENON C8H7ClO 154.59 ClCC(=O)c1ccccc1 99-02-5 1-(3-CHLORPHENYL)ETHANONE C8H7ClO 154.59 CC(=O)c(ccc1)cc1Cl 99-91-2 CHLORACETOPHENON C8H7ClO 154.59 CC(=O)c(cc1)ccc1Cl 874-60-2 4-methylbenzoylchloride C8H7ClO 154.59 ClC(=O)c(cc1)ccc1C 933-88-0 2-METHYLBENZOYLCHLORID C8H7ClO 154.59 ClC(=O)c1ccccc1C 1711-06-4 3-methylbenzoylchloride C8H7ClO 154.59 ClC(=O)c(ccc1)cc1C 104-52-9 (3-CHLORPROPYL)BENZOL C9H11Cl 154.64 ClCCCc1ccccc1 824-55-5 1-(chloromethyl)-2,4-dimethylbenzene C9H11Cl 154.64 ClCc1ccc(C)cc1C 2621-46-7 4-CHLORISOPROPYLBENZOL C9H11Cl 154.64 CC(C)c(cc1)ccc1Cl 2077-13-6 1-CHLOR-2-(1-METHYLETHYL)BENZOL C9H11Cl 154.64 CC(C)c1ccccc1Cl 1667-04-5 2-chloro-1,3,5-trimethylbenzene C9H11Cl 154.64 Cc(cc1C)cc(C)c1Cl 543-20-4 BUTANDIOYLDICHLORID C4H4Cl2O2 154.98 ClC(CCC(Cl)=O)=O 2163-00-0 1,6-DICHLORHEXAN C6H12Cl2 155.07 ClCCCCCCCl 2162-92-7 1,2-DICHLORHEXAN C6H12Cl2 155.07 CCCCC(Cl)CCl 1873-92-3 silane,dichloromethyl-2-propenyl- C4H8Cl2Si 155.10 C[Si](Cl)(Cl)CC=C 601-89-8 2-NITRO-1,3-BENZOLDIOL C6H5NO4 155.11 Oc1cccc(O)c1N(=O)=O 3163-07-3 4-NITRORESORCIN C6H5NO4 155.11 Oc(ccc1N(=O)=O)cc1O 3316-09-4 4-NITRO-1,2-BENZOLDIOL C6H5NO4 155.11 Oc1ccc(cc1O)N(=O)=O 446-34-4 2-fluoro-4-methyl-1-nitrobenzene C7H6FNO2 155.13 Cc(ccc1N(=O)=O)cc1F 71-00-1 L-ALPHA-AMINO-BETA-(4-IMIDAZOLYL)-PROPANSAEURE C6H9N3O2 155.16[NH3+]C(Cc1[nH]cnc1)C([O-])=O 480-85-3 retronecine C8H13NO2 155.20 OC2C1C(CO)=CCN1CC2 1008-89-5 2-PHENYLPYRIDIN C11H9N 155.20 c(cn2)ccc2c1ccccc1 64-65-3 4-ethyl-4-methyl-2,6-piperidinedione C8H13NO2 155.20 CCC1(C)CC(=O)NC(C1)=O 63-75-2 arecoline C8H13NO2 155.20 CN1CC(=CCC1)C(OC)=O 1008-88-4 3-PHENYLPYRIDIN C11H9N 155.20 c(nc2)ccc2c1ccccc1 939-23-1 4-PHENYLPYRIDIN C11H9N 155.20 n(cc2)ccc2c1ccccc1 38205-60-6 1-(2,4-dimethyl-1,3-thiazol-5-yl)ethanone C7H9NOS 155.22 CC(=O)c1sc(C)nc1C 14952-05-7 TRANS-2-NONENAMID C9H17NO 155.24 CCCCCCC=CC(=O)N 826-36-8 2,2,6,6-TETRAMETHYL-4-PIPERIDON C9H17NO 155.24 CC1(C)CC(CC(C)(C)N1)=O 79-55-0 1,2,2,6,6-pentamethylpiperidine C10H21N 155.28 CC1(C)CCCC(C)(C)N1C 35448-31-8 3-methyl-n-(3-methylbutyl)butan-1-imine C10H21N 155.28 CC(C)CCN=CCC(C)C 91-65-6 CYCLOHEXYLDIETHYLAMIN C10H21N 155.28 CCN(CC)C1CCCCC1 101-40-6 propylhexedrine C10H21N 155.28 CNC(C)CC1CCCCC1 618-48-4 3-CHLORBENZAMID C7H6ClNO 155.58 Clc1cc(ccc1)C(=O)N 619-56-7 4-CHLORBENZAMID C7H6ClNO 155.58 Clc1ccc(cc1)C(=O)N 609-66-5 2-chlorobenzamide C7H6ClNO 155.58 Clc1ccccc1C(=O)N 698-01-1 2-CHLOR-N,N-DIMETHYLBENZOLAMIN C8H10ClN 155.63 CN(C)c1ccccc1Cl 75-03-6 ETHYLIODID C2H5I 155.97 CCI 51-75-2 N-METHYL-BIS-(2-CHLOR-ETHYL)-AMIN C5H11Cl2N 156.05 ClCCN(C)CCCl 3238-40-2 2,5-FURANDICARBONSAEURE C6H4O5 156.09 OC(=O)c1oc(C(O)=O)cc1 555-15-7 nifuroxime C5H4N2O4 156.10 ON=Cc1oc(cc1)N(=O)=O 570-22-9 1h-imidazole-4,5-dicarboxylicacid C5H4N2O4 156.10 OC(=O)c1nc[nH]c1C(O)=O 65-86-1 oroticacid C5H4N2O4 156.10OC(=O)c1[nH]c(=O)[nH]c(=O)c1 24448-94-0 5,5-dimethyl-2,4,6(1h,3h,5h)-pyrimidinetrione C6H8N2O3 156.14 CC1(C)C(=O)NC(=O)NC1=O 366-18-7 2,2-BIPYRIDIN C10H8N2 156.18 c(cn1)ccc1c2ccccn2 66-77-3 1-NAPHTHALINCARBOXALDEHYD C11H8O 156.18 O=Cc2c1ccccc1ccc2 66-99-9 2-NAPHTHALDEHYD C11H8O 156.18 O=Cc2cc1ccccc1cc2 611-10-9 2-OXOCYCLOPENTANCARBONSAEUREETHYLESTER C8H12O3 156.18 CCOC(C1CCCC1=O)=O 95-04-5 ectylurea C7H12N2O2 156.18 CCC(=CC)C(=O)NC(=O)N 3438-48-0 4-phenylpyrimidine C10H8N2 156.18 n(cn2)ccc2c1ccccc1 581-50-0 2,3'-bipyridine C10H8N2 156.18 c(nc2)ccc2c1ccccn1 581-47-5 2,4'-bipyridine C10H8N2 156.18 n(cc2)ccc2c1ccccn1 581-46-4 3,3'-bipyridine C10H8N2 156.18 c(nc1)ccc1c2cccnc2 553-26-4 4,4-BIPYRIDIN C10H8N2 156.18 n(cc2)ccc2c1ccncc1 55764-25-5 s-(2-methylfuran-3-yl)ethanethioate C7H8O2S 156.20 CC(=O)Sc1ccoc1C 2810-04-0 THIOPHEN-2-CARBONSAEUREETHYLESTER C7H8O2S 156.20 CCOC(=O)c1sccc1 52911-98-5 4-methoxy-6-methyl-2-thiopyrone C7H8O2S 156.20 COC(C=C1C)=CC(O1)=S 536-57-2 p-toluenesulfinicacid C7H8O2S 156.20 Cc1ccc(S(O)=O)cc1 3112-85-4 (METHYLSULFONYL)BENZOL C7H8O2S 156.20 CS(c1ccccc1)(=O)=O

Page 75 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 52911-99-6 2-METHYL-6-(METHYLTHIO)-4H-PYRAN-4-ON C7H8O2S 156.20 CSC(O1)=CC(=O)C=C1C 14812-03-4 non-2-enoic acid C9H16O2 156.22 CCCCCCC=CC(O)=O 701-97-3 cyclohexanepropanoicacid C9H16O2 156.22 OC(CCC1CCCCC1)=O 3289-28-9 CYCLOHEXANCARBONSAEUREETHYLESTER C9H16O2 156.22 CCOC(C1CCCCC1)=O 7500-42-7 2-hydroxy-2,6,6-trimethylcyclohexan-1-one C9H16O2 156.22 OC1(C)CCCC(C)(C)C1=O 104-61-0 DIHYDRO-5-PENTYL-2(3H)-FURANON C9H16O2 156.22 CCCCCC1OC(CC1)=O 569-41-5 1,8-DIMETHYLNAPHTHALIN C12H12 156.22 Cc2c1c(ccc2)cccc1C 573-98-8 1,2-DIMETHYLNAPHTHALIN C12H12 156.22 Cc2ccc1ccccc1c2C 581-40-8 2,3-DIMETHYLNAPHTHALIN C12H12 156.22 Cc2cc1ccccc1cc2C 571-61-9 1,5-DIMETHYLNAPHTHALIN C12H12 156.22 Cc1cccc2c1cccc2C 939-27-5 2-ETHYLNAPHTHALIN C12H12 156.22 CCc2cc1ccccc1cc2 1127-76-0 1-ETHYLNAPHTHALIN C12H12 156.22 CCc2c1ccccc1ccc2 575-37-1 1,7-DIMETHYLNAPHTHALIN C12H12 156.22 Cc(ccc1ccc2)cc1c2C 571-58-4 1,4-DIMETHYLNAPHTHALIN C12H12 156.22 Cc2c1ccccc1c(C)cc2 575-41-7 1,3-DIMETHYLNAPHTHALIN C12H12 156.22 Cc2cc1ccccc1c(C)c2 575-43-9 1,6-DIMETHYLNAPHTHALIN C12H12 156.22 Cc(ccc1c2C)cc1ccc2 581-42-0 2,6-DIMETHYLNAPHTHALIN C12H12 156.22 Cc2cc1ccc(C)cc1cc2 582-16-1 2,7-DIMETHYLNAPHTHALIN C12H12 156.22 Cc(ccc1cc2)cc1cc2C 1883-78-9 2-(propan-2-ylsulfanylmethyl)furan C8H12OS 156.25 CC(C)SCc1occc1 496-74-2 4-methyl-1,2-benzenedithiol C7H8S2 156.27 Cc(ccc1S)cc1S 1321-89-7 ISODECANAL C10H20O 156.27 CC(C)CCCCCCC=O 106-22-9 CITRONELLOL C10H20O 156.27 OCCC(C)CCC=C(C)C 112-31-2 1-DECANAL C10H20O 156.27 CCCCCCCCCC=O 5988-91-0 3,7-DIMETHYLOCTANAL C10H20O 156.27 CC(C)CCCC(C)CC=O 7779-07-9 2,6-dimethyloctanal C10H20O 156.27 CCC(C)CCCC(C)C=O 624-16-8 4-DECANON C10H20O 156.27 CCCCCCC(CCC)=O 928-80-3 3-DECANON C10H20O 156.27 CCCCCCCC(CC)=O 693-54-9 2-DECANON C10H20O 156.27 CCCCCCCCC(C)=O 22104-80-9 (e)-dec-2-en-1-ol C10H20O 156.27 CCCCCCCC=CCO 1502-05-2 cyclodecanol C10H20O 156.27 OC1CCCCCCCCC1 499-69-4 (1r,2r,5r)-2-methyl-5-propan-2-ylcyclohexan-1-ol C10H20O 156.27 CC(C)C(CCC1C)CC1O 51100-54-0 dec-1-en-3-ol C10H20O 156.27 CCCCCCCC(O)C=C 89-78-1 (1R,2S,5R)-REL-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANOLC10H20O 156.27 CC(CCC1C(C)C)CC1O 2216-51-5 L-(-)-MENTHOL C10H20O 156.27 CC(CCC1C(C)C)CC1O 14173-25-2 methyldisulfanylbenzene C7H8S2 156.27 CSSc1ccccc1 2847-72-5 4-METHYLDECAN C11H24 156.31 CCCCCCC(C)CCC 6975-98-0 2-METHYLDECAN C11H24 156.31 CCCCCCCCC(C)C 1120-21-4 UNDECAN C11H24 156.31 CCCCCCCCCCC 589-57-1 ethylphosphorochloridite C4H10ClO2P 156.55 CCOP(Cl)OCC 635-93-8 5-chloro-2-hydroxybenzaldehyde C7H5ClO2 156.57 Clc(ccc1O)cc1C=O 2420-16-8 3-CHLOR-4-HYDROXYBENZALDEHYD C7H5ClO2 156.57 Oc1ccc(C=O)cc1Cl 74-11-3 4-CHLORBENZOESAEURE C7H5ClO2 156.57 OC(=O)c(cc1)ccc1Cl 118-91-2 2-CHLORBENZOESAEURE C7H5ClO2 156.57 OC(=O)c1ccccc1Cl 535-80-8 3-CHLORBENZOESAEURE C7H5ClO2 156.57 OC(=O)c(ccc1)cc1Cl 622-86-6 (2-CHLORETHOXY)BENZOL C8H9ClO 156.61 ClCCOc1ccccc1 1875-88-3 2-(4-CHLORPHENYL)-ETHANOL C8H9ClO 156.61 OCCc1ccc(Cl)cc1 88-04-0 4-CHLOR-3,5-DIMETHYLPHENOL C8H9ClO 156.61 Oc(cc1C)cc(C)c1Cl 622-61-7 P-CHLORPHENETOL C8H9ClO 156.61 CCOc1ccc(Cl)cc1 614-72-2 2-CHLORPHENETOL C8H9ClO 156.61 CCOc1ccccc1Cl 2655-83-6 1-chloro-3-ethoxybenzene C8H9ClO 156.61 CCOc1cc(Cl)ccc1 420-90-6 3-bromo-3,3-difluoro-1-propene C3H3BrF2 156.96 FC(F)(Br)C=C 535-15-9 DICHLORESSIGSAEUREETHYLESTER C4H6Cl2O2 157.00 CCOC(C(Cl)Cl)=O 628-11-5 carbonochloridicacid-3-chloropropylester C4H6Cl2O2 157.00 ClCCCOC(Cl)=O 95-59-0 2,3-dichloro-1,4-dioxane C4H6Cl2O2 157.00 ClC1OCCOC1Cl 108-86-1 BROMBENZOL C6H5Br 157.01 Brc1ccccc1 645-96-5 phenylselenium C6H6Se 157.08 [SeH]c1ccccc1 645-12-5 5-nitro-2-furoicacid C5H3NO5 157.08 OC(=O)c1oc(cc1)N(=O)=O 87-39-8 2,4,5,6(1h,3h)-pyrimidinetetrone-5-oxime C4H3N3O4 157.08 ON=C1C(=O)NC(=O)NC1=O 446-36-6 5-fluoro-2-nitrophenol C6H4FNO3 157.10 Fc(ccc1N(=O)=O)cc1O 403-19-0 2-fluoro-4-nitrophenol C6H4FNO3 157.10 Oc1ccc(cc1F)N(=O)=O 1719-53-5 DICHLORDIETHYLSILAN C4H10Cl2Si 157.11 CC[Si](Cl)(Cl)CC 98-10-2 BENZOLSULFONAMID C6H7NO2S 157.19 O=S(c1ccccc1)(=O)N

Page 76 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 2051-97-0 1-(phenylmethyl)-1h-pyrrole C11H11N 157.21 C(c2ccccc2)n1cccc1 1463-17-8 2,8-DIMETHYLCHINOLIN C11H11N 157.21 Cc2nc1c(cccc1C)cc2 2216-68-4 n-methyl-1-naphthalenamine C11H11N 157.21 CNc2c1ccccc1ccc2 2623-50-9 5,8-DIMETHYLCHINOLIN C11H11N 157.21 Cc2c1ncccc1c(C)cc2 2436-93-3 6,8-DIMETHYLCHINOLIN C11H11N 157.21 Cc2cc1cccnc1c(C)c2 126-93-2 oxanamide C8H15NO2 157.21 CCCC1OC1(CC)C(=O)N 1613-34-9 2-ethylquinoline C11H11N 157.21 CCc2nc1ccccc1cc2 2867-47-2 METHACRYLSAEURE-2-DIMETHYLAMINOETHYLESTER C8H15NO2 157.21 CN(C)CCOC(=O)C(C)=C 1721-89-7 2,3-DIMETHYLCHINOLIN C11H11N 157.21 Cc2nc1ccccc1cc2C 93-37-8 2,7-DIMETHYLCHINOLIN C11H11N 157.21 Cc2nc1cc(C)ccc1cc2 877-43-0 2,6-DIMETHYLCHINOLIN C11H11N 157.21 Cc2nc1ccc(C)cc1cc2 1198-37-4 2,4-DIMETHYLCHINOLIN C11H11N 157.21 Cc2nc1ccccc1c(C)c2 1873-54-7 3-ETHYLCHINOLIN C11H11N 157.21 CCc2cc1ccccc1nc2 2436-92-2 3,4-DIMETHYLCHINOLIN C11H11N 157.21 Cc2cnc1ccccc1c2C 1120-07-6 PELARGONSAEUREAMID C9H19NO 157.25 CCCCCCCCC(=O)N 533-32-4 isovaleryldiethylamide C9H19NO 157.25 CC(C)CC(=O)N(CC)CC 761-65-9 N,N-DIBUTYLFORMAMID C9H19NO 157.25 CCCCN(CCCC)C=O 2050-92-2 N-PENTYL-1-PENTANAMIN C10H23N 157.30 CCCCCNCCCCC 544-00-3 3-METHYL-N-(3-METHYLBUTYL)-1-BUTANAMIN C10H23N 157.30 CC(C)CCNCCC(C)C 2016-57-1 1-AMINODECAN C10H23N 157.30 NCCCCCCCCCC 109-70-6 1-BROM-3-CHLORPROPAN C3H6BrCl 157.44 ClCCCBr 3017-96-7 1-BROM-2-CHLORPROPAN C3H6BrCl 157.44 BrCC(C)Cl 3017-95-6 2-BROM-1-CHLORPROPAN C3H6BrCl 157.44 ClCC(C)Br 2310-98-7 2-bromo-2-chloropropane C3H6BrCl 157.44 CC(C)(Cl)Br 88-73-3 2-CHLORNITROBENZOL C6H4ClNO2 157.56 Clc1ccccc1N(=O)=O 121-73-3 3-CHLORNITROBENZOL C6H4ClNO2 157.56 Clc1cc(ccc1)N(=O)=O 100-00-5 4-CHLORNITROBENZOL C6H4ClNO2 157.56 Clc1ccc(cc1)N(=O)=O 4684-94-0 6-chloropicolinicacid C6H4ClNO2 157.56 OC(=O)c(ccc1)nc1Cl 93-50-5 4-CHLOR-2-METHOXYBENZOLAMIN C7H8ClNO 157.60 COc1cc(Cl)ccc1N 5345-54-0 3-CHLOR-4-METHOXYBENZOLAMIN C7H8ClNO 157.60 COc1ccc(N)cc1Cl 595-44-8 1,1-dichloro-1-nitropropane C3H5Cl2NO2 157.98 CCC(Cl)(Cl)N(=O)=O 109-04-6 2-BROMPYRIDIN C5H4BrN 158.00 Brc1ccccn1 626-55-1 3-BROMPYRIDIN C5H4BrN 158.00 Brc1cccnc1 1120-87-2 4-BROMPYRIDIN C5H4BrN 158.00 Brc1ccncc1 1571-33-1 PHENYLPHOSPHONSAEURE C6H7O3P 158.09 OP(O)(=O)c1ccccc1 385-00-2 2,6-difluorobenzoicacid C7H4F2O2 158.10 OC(=O)c1c(F)cccc1F 97-59-6 (2,5-DIOXO-4-IMIDAZOLIDINYL)HARNSTOFF C4H6N4O3 158.12 O=C(N)NC1NC(=O)NC1=O 869-29-4 allylidenediacetate C7H10O4 158.15 CC(OC(OC(C)=O)C=C)=O 3947-97-5 3-cyclobutene-1,2-dione,3-phenyl- C10H6O2 158.15 O=c(cc1c2ccccc2)c1=O 130-15-4 1,4-NAPHTHALINDION C10H6O2 158.15 O=C2C=CC(c1ccccc21)=O 617-52-7 METHYLENBERNSTEINSAEUREDIETHYLESTER C7H10O4 158.15 COC(=O)CC(=C)C(OC)=O 524-42-5 1,2-naphthalenedione C10H6O2 158.15 O=C2c1ccccc1C=CC2=O 79-91-4 tetrahydro-2,2-dimethyl-3-furancarboxylicacid C7H10O4 158.15 CC1(C)OC(CC1C(O)=O)=O 116-25-6 1-(hydroxymethyl)-5,5-dimethylhydantoin C6H10N2O3 158.16 OCN1C(=O)NC(C1(C)C)=O 98-11-3 BENZOLSULFONSAEURE C6H6O3S 158.18 OS(c1ccccc1)(=O)=O 97-72-3 2-METHYLPROPANSAEUREANHYDRID C8H14O3 158.20 CC(C)C(OC(C(C)C)=O)=O 106-31-0 BUTANSAEUREANHYDRID C8H14O3 158.20 CCCC(OC(CCC)=O)=O 93-04-9 2-METHOXYNAPHTHALIN C11H10O 158.20 COc2cc1ccccc1cc2 1592-38-7 NAPHTHALIN-2-METHANOL C11H10O 158.20 OCc2cc1ccccc1cc2 591-60-6 3-oxobutanoicacidbutylester C8H14O3 158.20 CCCCOC(CC(C)=O)=O 607-97-6 2-ETHYLACETESSIGSAUREETHYLESTER C8H14O3 158.20 CCOC(C(CC)C(C)=O)=O 1694-31-1 BUANOICACID,3-OXO-,1,1-DIMETHYLETHYLESTER C8H14O3 158.20 CC(C)(C)OC(CC(C)=O)=O 3637-14-7 5-oxooctanoic acid C8H14O3 158.20 CCCC(CCCC(O)=O)=O 479-27-6 1,8-DIAMINONAPHTHALIN C10H10N2 158.20 Nc1cccc(ccc2)c1c2N 637-65-0 tetrahydro-2-furanmethanolpropanoate C8H14O3 158.20 CCC(OCC1CCCO1)=O 2379-55-7 2,3-DIMETHYLQUINOXALIN C10H10N2 158.20 Cc2nc1ccccc1nc2C 771-97-1 2,3-naphthalenediamine C10H10N2 158.20 Nc2cc1ccccc1cc2N 2243-62-1 1,5-NAPHTHALINDIAMIN C10H10N2 158.20 Nc1cccc2c1cccc2N 2243-55-2 1-naphthylhydrazine C10H10N2 158.20 NNc2c1ccccc1ccc2 2243-61-0 1,4-naphthalenediamine C10H10N2 158.20 Nc2c1ccccc1c(N)cc2 3810-26-2 3-phenyl-2-cyclopenten-1-one C11H10O 158.20 O=C(CC1)C=C1c2ccccc2 487-19-4 1-methyl-2-(3-pyridyl)pyrrole C10H10N2 158.20 Cn1cccc1c2cccnc2

Page 77 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 120-43-4 1-piperazinecarboxylicacidethylester C7H14N2O2 158.20 CCOC(=O)N1CCNCC1 4238-71-5 1-(PHENYLMETHYL)-1H-IMIDAZOL C10H10N2 158.20 C(c2ccccc2)n1ccnc1 37933-88-3 (S)-2-(ACETYLAMINO)-3-METHYLBUTANAMID C7H14N2O2 158.20 CC(C)C(NC(C)=O)C(=O)N 2216-69-5 1-METHOXYNAPHTHALIN C11H10O 158.20 COc2c1ccccc1ccc2 328-57-4 DIFLUORMETHYLPHENYLSILAN C7H8F2Si 158.22 F[Si](F)(C)c1ccccc1 2050-01-3 2-METHYLPROPANSAEURE-3-METHYLBUTYLESTER C9H18O2 158.24 CC(C)CCOC(C(C)C)=O 540-18-1 BUTANSAEUREPENTYLESTER C9H18O2 158.24 CCCCCOC(CCC)=O 2445-76-3 PROPANSAEUREHEXYLESTER C9H18O2 158.24 CCCCCCOC(CC)=O 106-27-4 BUTANSAEURE-3-METHYLBUTYLESTER C9H18O2 158.24 CC(C)CCOC(CCC)=O 111-11-5 OCTANSAEUREMETHYLESTER C9H18O2 158.24 CCCCCCCC(OC)=O 626-77-7 HEXANSAEUREPROPYLESTER C9H18O2 158.24 CCCCCC(OCCC)=O 591-68-4 PENTANSAEUREBUTYLESTER C9H18O2 158.24 CCCCOC(CCCC)=O 112-32-3 AMEISENSAEUREOCTYLESTER C9H18O2 158.24 CCCCCCCCOC=O 589-59-3 3-METHYLBUTANSAEURE-2-METHYLPROPYLESTER C9H18O2 158.24 CC(C)COC(CC(C)C)=O 106-30-9 HEPTANSAEUREETHYLESTER C9H18O2 158.24 CCCCCCC(OCC)=O 1561-10-0 4-methylhexanoicacidethylester C9H18O2 158.24 CCC(C)CCC(OCC)=O 112-05-0 NONANSAEURE C9H18O2 158.24 CCCCCCCCC(O)=O 112-06-1 ESSIGSAEUREHEPTYLESTER C9H18O2 158.24 CCCCCCCOC(C)=O 1599-49-1 4-methyl-2-pentyl-1,3-dioxolane C9H18O2 158.24 CCCCCC(OC1)OC1C 3004-93-1 OCTANOICACID,2-METHYL C9H18O2 158.24 CCCCCCC(C)C(O)=O 59191-78-5 3-(hydroxymethyl)octan-2-one C9H18O2 158.24 CCCCCC(CO)C(C)=O 997-95-5 2-METHYL-N-(2-METHYLPROPYL)-N-NITROSO-1-PROPANAMINC8H18N2O 158.24 CC(C)CN(CC(C)C)N=O 67801-46-1 1-hydroxynonan-3-one C9H18O2 158.24 CCCCCCC(CCO)=O 4773-83-5 1H-INDENE,1,2,3-TRIMETHYL- C12H14 158.24 CC2c1ccccc1C(C)=C2C 771-98-2 1-CYCLOHEXEN-1-YLBENZOL C12H14 158.24 C(CC1)CC=C1c2ccccc2 480-72-8 1,2,2A,3,4,5-HEXAHYDROACENAPHTHYLEN C12H14 158.24 C3Cc2c1c(CCC1C3)ccc2 693-65-2 DIPENTYLETHER C10H22O 158.28 CCCCCOCCCCC 544-01-4 DIISOPENTYLETHER C10H22O 158.28 CC(C)CCOCCC(C)C 106-21-8 3,7-DIMETHYL-1-OCTANOL C10H22O 158.28 OCCC(C)CCCC(C)C 78-69-3 TETRAHYDROLINALOOL C10H22O 158.28 CC(C)CCCC(O)(C)CC 151-19-9 3,6-DIMETHYL-3-OCTANOL C10H22O 158.28 CCC(C)CCC(O)(C)CC 55505-26-5 ISODECANOL C10H22O 158.28 OCCCCCCCC(C)C 112-30-1 1-DECANOL C10H22O 158.28 OCCCCCCCCCC 2051-31-2 4-DECANOL C10H22O 158.28 CCCCCCC(O)CCC 1565-81-7 3-DECANOL C10H22O 158.28 CCCCCCCC(O)CC 140-80-7 1-DIETHYLAMINO-4-AMINOPENTAN C9H22N2 158.29 CCN(CC)CCCC(N)C 102-53-4 N,N,N,N-TETRAETHYLMETHYLENDIAMIN C9H22N2 158.29 CCN(CC)CN(CC)CC 998-29-8 TRIPROPYLSILAN C9H22Si 158.36 CCC[SiH](CCC)CCC 403-43-0 4-fluorobenzoylchloride C7H4ClFO 158.56 ClC(=O)c(cc1)ccc1F 393-52-2 2-FLUORBENZOYLCHLORID C7H4ClFO 158.56 ClC(=O)c1ccccc1F 1711-07-5 3-fluorobenzoylchloride C7H4ClFO 158.56 ClC(=O)c(ccc1)cc1F 2419-73-0 1,4-dichloro-2,3-butanediol C4H8Cl2O2 159.01 ClCC(O)C(O)CCl 505-60-2 BIS-(2-CHLORETHYL)-SULFID C4H8Cl2S 159.08 ClCCSCCCl 2265-94-3 3,5-DIFLUOR-1-NITROBENZOL C6H3F2NO2 159.09 Fc1cc(cc(F)c1)N(=O)=O 364-74-9 1,4-DIFLUOR-2-NITROBENZOL C6H3F2NO2 159.09 Fc(ccc1F)cc1N(=O)=O 446-35-5 2,4-DIFLUOR-1-NITROBENZOL C6H3F2NO2 159.09 Fc(ccc1N(=O)=O)cc1F 636-73-7 3-pyridinesulfonicacid C5H5NO3S 159.16 OS(c1cccnc1)(=O)=O 826-81-3 8-HYDROXYCHINALDIN C10H9NO 159.19 Cc2nc1c(cccc1O)cc2 607-67-0 2-METHYL-4-HYDROXYCHINOLIN C10H9NO 159.19 Cc2nc1ccccc1c(O)c2 84909-43-3 4-methyl-2-hydroxyquinoline C10H9NO 159.19 Oc2nc1ccccc1c(C)c2 703-80-0 1-(1h-indol-3-yl)-ethanone C10H9NO 159.19 CC(=O)c1c[nH]c2c1cccc2 5343-98-6 3-CYANO-1-PHENYLPROPAN-1-ON C10H9NO 159.19 N#CCCC(=O)c1ccccc1 118-46-7 8-amino-2-naphthalenol C10H9NO 159.19 Oc2cc1c(cccc1N)cc2 5263-87-6 6-METHOXYCHINOLIN C10H9NO 159.19 COc2cc1cccnc1cc2 606-43-9 1-methyl-2(h)-quinolinone C10H9NO 159.19 CN2c1ccccc1C=CC2=O 607-66-9 4-METHYL-2(1H)-CHINOLINON C10H9NO 159.19 CC2=CC(=O)Nc1ccccc21 607-31-8 4-methoxyquinoline C10H9NO 159.19 COc2c1ccccc1ncc2 938-33-0 8-METHOXYCHINOLIN C10H9NO 159.19 COc2c1ncccc1ccc2 83-54-5 1-methyl-4(1h)-quinolinone C10H9NO 159.19 CN2C=CC(c1ccccc21)=O 1971-46-6 1,2,3-trimethyl-1h-indole C11H13N 159.23 Cc2n(C)c1ccccc1c2C 629-46-9 nitrousacidoctylester C8H17NO2 159.23 CCCCCCCCON=O 1002-57-9 8-AMINOOCTANSAEURE C8H17NO2 159.23 [NH3+]CCCCCCCC([O-])=O

Page 78 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 7726-95-6 BROM Br2 159.81 BrBr 368-43-4 BENZOLSULFONYLFLUORID C6H5FO2S 160.17 FS(c1ccccc1)(=O)=O 510-20-3 DIETHYLPROPANDISAEURE C7H12O4 160.17 CCC(CC)(C(O)=O)C(O)=O 534-59-8 BUTYLPROPANDISAEURE C7H12O4 160.17 CCCCC(C(O)=O)C(O)=O 105-53-3 PROPANDISAEUREDIETHYLESTER C7H12O4 160.17 CCOC(CC(OCC)=O)=O 1604-11-1 METHYLBUTANDISAEUREDIMETHYLESTER C7H12O4 160.17 COC(CC(C)C(OC)=O)=O 627-73-6 BUTANDISAEUREETHYLMETHYLESTER C7H12O4 160.17 CCOC(CCC(OC)=O)=O 1646-26-0 1-(2-benzofuranyl)ethanone C10H8O2 160.17 CC(=O)c(cc1cc2)oc1cc2 627-91-8 HEXANDISAEUREMONOMETHYLESTER C7H12O4 160.17 COC(CCCCC(O)=O)=O 681-57-2 2,2-DIMETHYLGLUTARICACID C7H12O4 160.17 CC(C)(CCC(O)=O)C(O)=O 626-70-0 2-methylhexanedioicacid C7H12O4 160.17 CC(CCCC(O)=O)C(O)=O 2445-82-1 3-methyl-2h-1-benzopyran-2-one C10H8O2 160.17 CC2=Cc1ccccc1OC2=O 111-16-0 1,7-HEPTANDISAEURE C7H12O4 160.17 OC(CCCCCC(O)=O)=O 1119-40-0 PENTANDISAEUREDIMETHYLESTER C7H12O4 160.17 COC(CCCC(OC)=O)=O 92-48-8 6-METHYL_COUMARIN C10H8O2 160.17 Cc(ccc1O2)cc1C=CC2=O 623-84-7 1,2-PROPANDIOLDIACETAT C7H12O4 160.17 CC(COC(C)=O)OC(C)=O 2445-83-2 7-METHYL_COUMARIN C10H8O2 160.17 Cc(ccc1C=CC2=O)cc1O2 126-54-5 DI-O-METHYLENPENTAERYTHRITOL C7H12O4 160.17 C(OC1)OCC21COCOC2 628-66-0 1,3-PROPYLENGLYCOLDIACETAT C7H12O4 160.17 CC(OCCCOC(C)=O)=O 85-90-5 tricromyl C10H8O2 160.17 CC2=COc1ccccc1C2=O 581-43-1 2,6-NAPHTHALINDIOL C10H8O2 160.17 Oc2cc1ccc(O)cc1cc2 582-17-2 2,7-NAPHTHALINDIOL C10H8O2 160.17 Oc(ccc1cc2)cc1cc2O 571-60-8 1,4-DIHYDROXYNAPHTHALIN C10H8O2 160.17 Oc2c1ccccc1c(O)cc2 575-38-2 naphthalene-1,7-diol C10H8O2 160.17 Oc(ccc1ccc2)cc1c2O 92-44-4 2,3-DIHYDROXYNAPHTHALIN C10H8O2 160.17 Oc2cc1ccccc1cc2O 574-00-5 1,2-DIHYDROXYNAPHTHALIN C10H8O2 160.17 Oc2ccc1ccccc1c2O 575-44-0 1,6-naphthalenediol C10H8O2 160.17 Oc2cc(cccc1O)c1cc2 132-86-5 1,3-NAPHTHALINDIOL C10H8O2 160.17 Oc2cc1ccccc1c(O)c2 83-56-7 1,5-NAPHTHALINDIOL C10H8O2 160.17 Oc1cccc2c1cccc2O 1596-84-5 BUTANDISAEUREMONO(2,2-DIMETHYLHYDRAZID) C6H12N2O3 160.17 OC(=O)CCC(=O)NN(C)C 86-54-4 hydralazine C8H8N4 160.18 NNc2c1ccccc1cnn2 24401-36-3 2-phenylpent-4-enal C11H12O 160.21 C=CCC(C=O)c1ccccc1 939-21-9 3-phenylpent-4-enal C11H12O 160.21 O=CCC(C=C)c1ccccc1 112-07-2 BUTYLGLYKOLACETAT C8H16O3 160.21 CCCCOCCOC(C)=O 3152-68-9 1-PHENYL-1-PENTEN-3-ON C11H12O 160.21 CCC(=O)C=Cc1ccccc1 64001-06-5 1-BUTANOL,4-[(TETRAHYDRO-2-FURANYL)OXY]- C8H16O3 160.21 OCCCCOC1CCCO1 59-98-3 4,5-dihydro-2-(phenylmethyl)-1h-imidazole C10H12N2 160.22 C(CN1)N=C1Cc2ccccc2 91-60-1 2-NAPHTHALINTHIOL C10H8S 160.24 Sc2cc1ccccc1cc2 529-36-2 1-naphthalenethiol C10H8S 160.24 Sc2c1ccccc1ccc2 2568-90-3 FORMALDEHYDDIBUTYLACETAL C9H20O2 160.25 CCCCOCOCCCC 115-84-4 2-ETHYL-2-HYDROXYMETHYL-1-HEXANOL C9H20O2 160.25 CCCCC(CO)(CO)CC 3937-56-2 1,9-NONANDIOL C9H20O2 160.25 OCCCCCCCCCO 2568-91-4 DIISOBUTOXYMETHAN C9H20O2 160.25 CC(C)COCOCC(C)C 57500-00-2 2-(methyldisulfanylmethyl)furan C6H8OS2 160.26 CSSCc1occc1 1746-23-2 BENZENE,1-(1,1-DIMETHYLETHYL)-4-ETHENYL- C12H16 160.26 CC(C)(C)c1ccc(C=C)cc1 6047-69-4 BENZENE,1-METHYL-2-(3-PENTENYL)- C12H16 160.26 CC=CCCc1ccccc1C 63444-56-4 BENZENE,1-ETHENYL-4-(2-METHYLPROPYL) C12H16 160.26 CC(C)Cc1ccc(C=C)cc1 2388-14-9 1-(1-METHYLETHENYL)-4-(1-METHYLETHYL)-BENZOL C12H16 160.26 CC(C)c1ccc(C(C)=C)cc1 1985-59-7 1,1-DIMETHYLTETRALIN C12H16 160.26 CC2(C)c1ccccc1CCC2 13556-58-6 1-ETHYL-1,2,3,4-TETRAHYDRONAPHTHALIN C12H16 160.26 CCC2c1ccccc1CCC2 4175-54-6 1,2,3,4-tetrahydro-1,4-dimethylnaphthalene C12H16 160.26 CC2c1ccccc1C(C)CC2 827-52-1 CYCLOHEXYLBENZOL C12H16 160.26 C(CC2)CCC2c1ccccc1 1076-61-5 1,2,3,4-TETRAHYDRO-6,7-DIMETHYLNAPHTHALEN C12H16 160.26 Cc2cc1CCCCc1cc2C 26472-00-4 3A,4,7,7A-TETRAHYDRODIMETHYL-4,7-METHANO-1H-INDENEC12H16 160.26CC(C1C2C3)=CCC1C3C=C2C 334-56-5 1-FLUORDECAN C10H21F 160.27 FCCCCCCCCCC 67715-80-4 2-methyl-4-propyl-1,3-oxathiane C8H16OS 160.28 CCCC(CCO1)SC1C 5507-44-8 silane,ethenyldiethoxymethyl- C7H16O2Si 160.29 CCO[Si](C)(OCC)C=C 3698-95-1 1-(METHYLTHIO)OCTAN C9H20S 160.32 CCCCCCCCSC 1455-21-6 1-NONANTHIOL C9H20S 160.32 CCCCCCCCCS 25360-10-5 TERT-NONANETHIOL C9H20S 160.32 CCCCCCC(C)(C)S 598-73-2 BROMTRIFLUORETHEN C2BrF3 160.92 FC(F)=C(F)Br 98-87-3 BENZALCHLORID C7H6Cl2 161.03 ClC(Cl)c1ccccc1

Page 79 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 104-83-6 1-CHLOR-4-(CHLORMETHYL)BENZOL C7H6Cl2 161.03 ClCc(cc1)ccc1Cl 620-20-2 1-CHLOR-3-(CHLORMETHYL)BENZOL C7H6Cl2 161.03 ClCc(ccc1)cc1Cl 611-19-8 1-CHLOR-1-(CHLORMETHYL)BENZOL C7H6Cl2 161.03 ClCc1ccccc1Cl 95-75-0 1,2-DICHLOR-4-METHYLBENZOL C7H6Cl2 161.03 Cc(ccc1Cl)cc1Cl 95-73-8 2,4-DICHLOR-1-METHYLBENZOL C7H6Cl2 161.03 Clc(ccc1C)cc1Cl 118-69-4 1,3-DICHLOR-2-METHYLBENZOL C7H6Cl2 161.03 Clc1cccc(Cl)c1C 17505-12-3 1,2,5-selenadiazole,3,4-dimethyl- C4H6N2Se 161.07 CC31N=[Se]21=NC32C 88-17-5 2-(TRIFLUORMETHYL)BENZOLAMIN C7H6F3N 161.13 FC(F)(F)c1ccccc1N 98-16-8 3-TRIFLUORMETHYLANILIN C7H6F3N 161.13 FC(F)(F)c(ccc1)cc1N 455-14-1 p-trifluoromethylaniline C7H6F3N 161.13 FC(F)(F)c(cc1)ccc1N 550-44-7 2-METHYL-1H-ISOINDOL-1,3(2H)-DION C9H7NO2 161.16 CN2C(c1ccccc1C2=O)=O 2058-74-4 n-methylindol-2,3-dione C9H7NO2 161.16 CN2c1ccccc1C(=O)C2=O 771-50-6 indole,3-carboxylicacid C9H7NO2 161.16 OC(=O)c1c[nH]c2c1cccc2 2904-57-6 2,4,6-TRIMETHYLBENZONITRIL-N-OXID C10H11NO 161.20 Cc(cc1C)cc(C)c1C#[N+][O-] 526-55-6 3-(2-hydroxyethyl)-1h-indole C10H11NO 161.20 OCCc1c[nH]c2c1cccc2 102-79-4 N-BUTYLDIETHANOLAMIN C8H19NO2 161.24 CCCCN(CCO)CCO 23074-42-2 TRICYCLO(3.3.1.1(3,7))DECAN-1-CARBONITRIL C11H15N 161.24N#CC1(CC3C2)CC2CC(C3)C1 771-99-3 4-PHENYLPIPERIDIN C11H15N 161.24 N(CC2)CCC2c1ccccc1 140-82-9 DIETHYLAMINOETHOXYETHANOL C8H19NO2 161.24 OCCOCCN(CC)CC 4096-20-2 1-PHENYLPIPERIDIN C11H15N 161.24 C(CC2)CCN2c1ccccc1 4430-36-8 1-isothiocyanato-4-methylsulfanylbutane C6H11NS2 161.29 CSCCCCN=C=S 999-97-3 1,1,1-trimethyl-n-(trimethylsilyl)-silanamine C6H19NSi2 161.39 C[Si](C)(C)N[Si](C)(C)C 3083-23-6 (TRICHLORMETHYL)OXIRAN C3H3Cl3O 161.42 ClC(Cl)(Cl)C1OC1 918-00-3 1,1,1-trichloroacetone C3H3Cl3O 161.42 ClC(Cl)(Cl)C(C)=O 75-94-5 VINYLTRICHLORSILAN C2H3Cl3Si 161.49 Cl[Si](Cl)(Cl)C=C 608-31-1 2,6-DICHLORBENZOLAMIN C6H5Cl2N 162.02 Clc1cccc(Cl)c1N 608-27-5 2,3-DICHLORBENZOLAMIN C6H5Cl2N 162.02 Nc1cccc(Cl)c1Cl 554-00-7 2,4-DICHLORBENZOLAMIN C6H5Cl2N 162.02 Clc(ccc1N)cc1Cl 95-82-9 2,5-DICHLORBENZOLAMIN C6H5Cl2N 162.02 Clc(ccc1Cl)cc1N 95-76-1 3,4-DICHLORBENZOLAMINE C6H5Cl2N 162.02 Nc(ccc1Cl)cc1Cl 626-43-7 3,5-DICHLORBENZOLAMIN C6H5Cl2N 162.02 Nc1cc(Cl)cc(Cl)c1 685-63-2 1,1,2,3,4,4-HEXAFLUOR-1,3-BUTADIEN C4F6 162.03 FC(F)=C(F)C(F)=C(F)F 697-11-0 hexafluorocyclobutene C4F6 162.03 FC1(F)C(F)=C(F)C1(F)F 692-50-2 1,1,1,4,4,4-hexafluoro-2-butyne C4F6 162.03 FC(F)(F)C#CC(F)(F)F 444-30-4 2-(TRIFLUORMETHYL)PHENOL C7H5F3O 162.11 FC(F)(F)c1ccccc1O 98-17-9 3-HYDROXY-A,A,A-TRIFLUORTOLUOL C7H5F3O 162.11 FC(F)(F)c(ccc1)cc1O 402-45-9 p-trifluoromethylphenol C7H5F3O 162.11 FC(F)(F)c(cc1)ccc1O 456-55-3 TRIFLUOROMETHYLPHENYLETHER C7H5F3O 162.11 FC(F)(F)Oc1ccccc1 617-75-4 TRIETHYLARSIN C6H15As 162.11 CC[As](CC)CC 824-11-3 4-ethyl-2,6,7-trioxa-1-phosphabicyclo[2,2,2]octane C6H11O3P 162.12 CCC1(CO2)COP2OC1 77-81-6 tabun C5H11N2O2P 162.13 CCOP(=O)(N(C)C)C#N 496-41-3 2-benzofurancarboxylicacid C9H6O3 162.14 OC(=O)c(cc1cc2)oc1cc2 93-35-6 7-HYDROXY_COUMARIN C9H6O3 162.14 Oc(ccc1C=CC2=O)cc1O2 19201-34-4 2,4-DIMETHYL-3-OXAPENTANDISAEURE C6H10O5 162.14 CC(OC(C)C(O)=O)C(O)=O 498-07-7 1,6-DIHYDRO-BETA-D-GLUCOSE C6H10O5 162.14 OC2C(O)C(CO1)OC1C2O 610-66-2 2-nitrobenzeneacetonitrile C8H6N2O2 162.15 N#CCc1ccccc1N(=O)=O 555-21-5 4-nitrobenzeneacetonitrile C8H6N2O2 162.15 N#CCc1ccc(cc1)N(=O)=O 2423-66-7 quindoxin C8H6N2O2 162.15 O=n2c1ccccc1n(=O)cc2 530-62-1 1,1'-carbonylbis-1h-imidazole C7H6N4O 162.15 O=C(n2ccnc2)n1ccnc1 2518-24-3 3-AMINOPHTHALAMID C8H6N2O2 162.15 Nc1cccc2c1C(=O)NC2=O 771-39-1 2-nh2-1,3-benzoxazin-4-one C8H6N2O2 162.15 NC2=NC(c1ccccc1O2)=O 771-41-5 4,7-pteridinediamine C6H6N6 162.15 Nc(cnc1c2N)nc1ncn2 3676-85-5 4-AMINOPHTHALIMID C8H6N2O2 162.15 Nc(ccc21)cc1C(=O)NC2=O 557-25-5 BUTTERSAEURE-2,3-DIHYDROXYPROPYLESTER C7H14O4 162.18 OCC(O)COC(CCC)=O 120-58-1 5-(1-PROPENYL)-1,3-BENZODIOXOL C10H10O2 162.19 CC=Cc2cc1OCOc1cc2 15844-05-0 PENTACYCLO(4.3.0.0(2,5).0(3,8).0(4,7))NONAN-4-CARBONSAEUREC10H10O2 162.19OC(C42C3C5C2C1C4C3C1C5)=O 94-59-7 5-(2-PROPENYL)-1,3-BENZODIOXOL C10H10O2 162.19 C=CCc2cc1OCOc1cc2 93-91-4 1-PHENYL-1,3-BUTANDION C10H10O2 162.19 CC(=O)CC(=O)c1ccccc1 2243-53-0 4-phenyl-3-butenoicacid C10H10O2 162.19 OC(CC=Cc1ccccc1)=O 1009-61-6 1,4-DIACETYLBENZOL C10H10O2 162.19 CC(=O)c1ccc(C(C)=O)cc1 65181-92-2 4,2,7-ethanylylidenecyclopenta[b]pyran-9-one,2,3, C10H10O2 162.19O=C4C2C3C=CC1C4CC2OC31 92-43-3 1-PHENYL-3-PYRAZOLIDINON C9H10N2O 162.19 O=C(CC2)NN2c1ccccc1

Page 80 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 368-47-8 TRIFLUORPHENYLSILAN C6H5F3Si 162.19 F[Si](F)(F)c1ccccc1 2439-44-3 3-methyl-2-phenylbutanal C11H14O 162.23 CC(C)C(C=O)c1ccccc1 582-62-7 3-METHYL-1-PHENYL-1-BUTANON C11H14O 162.23 CC(C)CC(=O)c1ccccc1 938-16-9 2,2-DIMETHYL-1-PHENYL-1-PROPANON C11H14O 162.23 CC(C)(C)C(=O)c1ccccc1 1009-14-9 1-PHENYL-1-PENTANON C11H14O 162.23 CCCCC(=O)c1ccccc1 4395-92-0 2-(4-propan-2-ylphenyl)acetaldehyde C11H14O 162.23 CC(C)c1ccc(CC=O)cc1 40654-82-8 2-methyl-4-phenylbutanal C11H14O 162.23 CC(CCc1ccccc1)C=O 1667-01-2 1-(2,4,6-TRIMETHYLPHENYL)ETHANON C11H14O 162.23 CC(=O)c1c(C)cc(C)cc1C 78-39-7 1,1,1-TRIETHOXYETHAN C8H18O3 162.23 CCOC(C)(OCC)OCC 645-13-6 1-(4-(1-METHYLETHYL)PHENYL)ETHANON C11H14O 162.23 CC(C)c1ccc(C(C)=O)cc1 2040-07-5 1-(2,4,5-TRIMETHYLPHENYL)ETHANON C11H14O 162.23 CC(=O)c(cc1C)c(C)cc1C 7774-79-0 4-(4-methylphenyl)butan-2-one C11H14O 162.23 CC(CCc(cc1)ccc1C)=O 112-34-5 2-(2-BUTOXYETHOXY)ETHANOL C8H18O3 162.23 OCCOCCOCCCC 1518-83-8 4-CYCLOPENTYLPHENOL C11H14O 162.23 Oc2ccc(C1CCCC1)cc2 30025-38-8 DIPROPYLENGLYKOLMONOETHYLETHER C8H18O3 162.23 CCOCC(C)OCC(O)C 112-36-7 DIETHYLENGLYKOLDIETHYLETHER C8H18O3 162.23 CCOCCOCCOCC 92-54-6 N-PHENYLPIPERAZIN C10H14N2 162.23 N(CC2)CCN2c1ccccc1 54-11-5 (S)-3-(1-METHYL-2-PYRROLIDINYL)PYRIDIN C10H14N2 162.23 CN1CCCC1c2cccnc2 34545-88-5 7-methyl-4,4a,5,6-tetrahydro-3h-naphthalen-2-one C11H14O 162.23 CC(CCC1CC2)=CC1=CC2=O 494-52-0 (S)-3-(2-PIPERIDINYL)PYRIDIN C10H14N2 162.23 C(CN1)CCC1c2cccnc2 31283-14-4 3-ethylbenzo[b]thiophene C10H10S 162.25 CCc2c1ccccc1sc2 1964-45-0 3,5-dimethylbenzo[b]thiophene C10H10S 162.25 Cc(ccc1sc2)cc1c2C 4923-91-5 BENZO[B]THIOPHENE,2,3-DIMETHYL- C10H10S 162.25 Cc2sc1ccccc1c2C 16587-40-9 BENZO[B]THIOPHENE,2,7-DIMETHYL C10H10S 162.25 Cc2sc1c(cccc1C)c2 1196-81-2 2-ETHYLBENZO(B)THIOPHEN C10H10S 162.25 CCc2sc1ccccc1c2 87-85-4 HEXAMETHYLBENZOL C12H18 162.27 Cc1c(C)c(C)c(C)c(C)c1C 1985-57-5 (1,1-DIMETHYLBUTYL)BENZOL C12H18 162.27 CCCC(C)(C)c1ccccc1 706-31-0 (1E,5E,9Z)-1,5,9-CYCLODODECATRIEN C12H18 162.27 C1C=CCCC=CCCC=CC1 42205-08-3 1,2,3-TRIETHYLBENZOL C12H18 162.27 CCc1cccc(CC)c1CC 2765-29-9 (e,z,z)-1,5,9-cyclododecatriene C12H18 162.27 C1C=CCCC=CCCC=CC1 1985-97-3 (1-ETHYL-1-METHYLPROPYL)BENZOL C12H18 162.27 CCC(C)(CC)c1ccccc1 577-55-9 1,2-BIS(1-METHYLETHYL)BENZOL C12H18 162.27 CC(C)c1ccccc1C(C)C 1077-16-3 HEXYLBENZOL C12H18 162.27 CCCCCCc1ccccc1 98-19-1 1-(1,1-DIMETHYLETHYL)-3,5-DIMETHYLBENZOL C12H18 162.27 CC(C)(C)c(cc1C)cc(C)c1 7364-19-4 1-ETHYL-4-TERT.-BUTYLBENZOL C12H18 162.27 CCc1ccc(C(C)(C)C)cc1 99-62-7 1,3-BIS(1-METHYLETHYL)BENZOL C12H18 162.27 CC(C)c1cc(C(C)C)ccc1 100-18-5 1,4-DIISOPROPYLBENZOL C12H18 162.27 CC(C)c1ccc(C(C)C)cc1 877-44-1 1,2,4-TRIETHYLBENZOL C12H18 162.27 CCc(ccc1CC)cc1CC 102-25-0 1,3,5-TRIETHYLBENZOL C12H18 162.27 CCc1cc(CC)cc(CC)c1 533-74-4 dmtt(dazomet) C5H10N2S2 162.28 CN(CSC1=S)CN1C 99-00-3 picadex C5H10N2S2 162.28 SC(=S)N1CCNCC1 2168-93-6 DIBUTYLSULFOXID C8H18OS 162.29 CCCCS(CCCC)=O 7790-99-0 IODMONOCHLORID ClI 162.36 ICl 107-46-0 HEXAMETHYLDISILOXAN C6H18OSi2 162.38 C[Si](C)(C)O[Si](C)(C)C 594-65-0 TRICHLORACETAMID C2H2Cl3NO 162.40 ClC(Cl)(Cl)C(=O)N 91-58-7 2-CHLORNAPHTHALIN C10H7Cl 162.62 Clc2cc1ccccc1cc2 90-13-1 1-CHLORNAPHTHALIN C10H7Cl 162.62 Clc2c1ccccc1ccc2 111-64-8 OCTANOYLCHLORID C8H15ClO 162.66 CCCCCCCC(Cl)=O 2473-01-0 1-NONYLCHLORID C9H19Cl 162.70 CCCCCCCCCCl 421-06-7 2-BROM-1,1,1-TRIFLUORETHAN C2H2BrF3 162.94 BrCC(F)(F)F 87-65-0 2,6-DICHLORPHENOL C6H4Cl2O 163.00 Clc1cccc(Cl)c1O 576-24-9 2,3-DICHLORPHENOL C6H4Cl2O 163.00 Oc1cccc(Cl)c1Cl 120-83-2 2,4-DICHLORPHENOL C6H4Cl2O 163.00 Clc(ccc1O)cc1Cl 583-78-8 2,5-DICHLORPHENOL C6H4Cl2O 163.00 Clc(ccc1Cl)cc1O 95-77-2 3,4-DICHLORPHENOL C6H4Cl2O 163.00 Oc(ccc1Cl)cc1Cl 591-35-5 3,5-DICHLORPHENOL C6H4Cl2O 163.00 Oc1cc(Cl)cc(Cl)c1 1780-31-0 2,4-dichloro-5-methylpyrimidine C5H4Cl2N2 163.01 Clc(ncc1C)nc1Cl 1622-32-8 2-chloroethanesulfonylchloride C2H4Cl2O2S 163.02 ClCCS(Cl)(=O)=O 872-31-1 3-BROMTHIOPHEN C4H3BrS 163.04 Brc1cscc1 1003-09-4 2-BROMTHIOPHEN C4H3BrS 163.04 Brc1sccc1 108-85-0 BROMCYCLOHEXAN C6H11Br 163.06 BrC1CCCCC1 524-38-9 1H-ISOINDOL-2-HYDROXY-1,3(2H)-DION C8H5NO3 163.13 ON2C(c1ccccc1C2=O)=O

Page 81 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 94-52-0 5-nitro-1h-benzimidazole C7H5N3O2 163.13 O=N(=O)c2cc1nc[nH]c1cc2 122-85-0 N-(4-FORMYLPHENYL)ACETAMID C9H9NO2 163.17 O=Cc1ccc(cc1)NC(C)=O 3594-37-4 1-(3-pyridinyl)-1,3-butanedione C9H9NO2 163.17 CC(=O)CC(=O)c1cccnc1 150-25-4 n,n-bis(2-hydroxyethyl)glycine C6H13NO4 163.17 OCCN(CCO)CC(O)=O 616-91-1 n-acetyl-l-cysteine C5H9NO3S 163.20 SCC(C(O)=O)NC(C)=O 1608-26-0 TRIS-(DIMETHYLAMINO)-PHOSPHIN C6H18N3P 163.20 CN(C)P(N(C)C)N(C)C 120-15-0 1,2,3,4-tetrahydro-6-methoxyquinoline C10H13NO 163.22 COc2cc1CCCNc1cc2 1129-50-6 n-phenylbutanamide C10H13NO 163.22 CCCC(=O)Nc1ccccc1 2050-43-3 N-(2,4-DIMETHYLPHENYL)ACETAMID C10H13NO 163.22 Cc(ccc1NC(C)=O)cc1C 90-26-6 a-ethylbenzeneacetamide C10H13NO 163.22 CCC(c1ccccc1)C(=O)N 2198-53-0 2,6-dimethylacetanilide C10H13NO 163.22 Cc1cccc(C)c1NC(C)=O 529-65-7 N-ETHYL-N-PHENYLACETAMID C10H13NO 163.22 CCN(c1ccccc1)C(C)=O 6935-65-5 N,N,3-TRIMETHYLBENZAMID C10H13NO 163.22 Cc1cc(ccc1)C(=O)N(C)C 14062-78-3 n,n,4-trimethylbenzamide C10H13NO 163.22 Cc1ccc(cc1)C(=O)N(C)C 573-26-2 n-methyl-o-acetotoluidide C10H13NO 163.22 Cc1ccccc1N(C)C(C)=O 2257-09-2 2-isothiocyanatoethylbenzene C9H9NS 163.24 S=C=NCCc1ccccc1 2243-30-3 2,3,4,5,6-pentamethylbenzenamine C11H17N 163.26 Nc1c(C)c(C)c(C)c(C)c1C 613-48-9 n,n-diethyl-4-methylbenzenamine C11H17N 163.26 CCN(CC)c(cc1)ccc1C 606-46-2 n,n-diethyl-2-methylbenzenamine C11H17N 163.26 CCN(CC)c1ccccc1C 638-17-5 dihydro-2,4,6-trimethyl-4h-1,3,5-dithiazine C6H13NS2 163.31 CC1SC(C)SC(C)N1 76-03-9 TRICHLORESSIGSAEURE C2HCl3O2 163.39 ClC(Cl)(Cl)C(O)=O 76-00-6 1,1,1-trichloro-2-propanol C3H5Cl3O 163.43 OC(C)C(Cl)(Cl)Cl 1558-33-4 METHYLCHLORMETHYLDICHLORSILAN C2H5Cl3Si 163.51 ClC[Si](C)(Cl)Cl 115-21-9 TRICHLORETHYLSILAN C2H5Cl3Si 163.51 CC[Si](Cl)(Cl)Cl 612-62-4 2-CHLORCHINOLIN C9H6ClN 163.60 Clc2nc1ccccc1cc2 611-33-6 8-chloroquinoline C9H6ClN 163.60 Clc2c1ncccc1ccc2 612-57-7 6-CHLORCHINOLIN C9H6ClN 163.60 Clc2cc1cccnc1cc2 75-27-4 BROMDICHLORMETHAN CHBrCl2 163.83 ClC(Cl)Br 3034-53-5 2-bromothiazole C3H2BrNS 164.02 Brc1sccn1 402-44-8 1-FLUOR-4-(TRIFLUORMETHYL)-BENZOL C7H4F4 164.10 FC(F)(F)c(cc1)ccc1F 392-85-8 1-FLUOR-2-(TRIFLUORMETHYL)BENZOL C7H4F4 164.10 FC(F)(F)c1ccccc1F 3320-86-3 1-ISOCYANATO-2-NITROBENZOL C7H4N2O3 164.12 O=C=Nc1ccccc1N(=O)=O 3320-87-4 1-ISOCYANATO-3-NITROBENZOL C7H4N2O3 164.12 O=C=Nc1cc(ccc1)N(=O)=O 100-28-7 1-ISOCYANATO-4-NITROBENZOL C7H4N2O3 164.12 O=C=Nc1ccc(cc1)N(=O)=O 1516-60-5 1-AZIDO-4-NITROBENZOL C6H4N4O2 164.12 N#N=Nc1ccc(cc1)N(=O)=O 2338-12-7 5-nitrobenzotriazole C6H4N4O2 164.12 O=N(=O)c2cc1nn[nH]c1cc2 487-21-8 lumazine C6H4N4O2 164.12 O=c2[nH]c(=O)c1nccnc1[nH]2 129-64-6 NORBORN-5-EN-2,3-DICARBONSAEURE-ANHYDRID C9H8O3 164.16O=C3OC(C2C3C1C=CC2C1)=O 1571-08-0 BENZOICACID,4-FORMYL-,METHYLESTER C9H8O3 164.16 COC(=O)c(cc1)ccc1C=O 586-89-0 p-acetylbenzoicacid C9H8O3 164.16 OC(=O)c1ccc(C(C)=O)cc1 577-56-0 o-acetylbenzoicacid C9H8O3 164.16 OC(=O)c1ccccc1C(C)=O 156-06-9 2-oxo-3-phenylpropanoic acid C9H8O3 164.16 OC(=O)C(Cc1ccccc1)=O 3615-41-6 2,3,4,5-tetrahydroxyhexanal C6H12O5 164.16 OC(C)C(O)C(O)C(O)C=O 524-40-3 ricidine C8H8N2O2 164.16 COC(C=CN1C)=C(C#N)C1=O 88-96-0 1,2-benzenedicarboxamide C8H8N2O2 164.16 O=C(N)c1ccccc1C(=O)N 1740-57-4 1,3-BENZOLDICARBOXAMID C8H8N2O2 164.16 O=C(N)c1cc(ccc1)C(=O)N 3010-82-0 terephthalamide C8H8N2O2 164.16 O=C(N)c1ccc(cc1)C(=O)N 31010-51-2 9h-purin-6(1h)-one,9-ethyl- C7H8N4O 164.17 CCn1cnc2c1N=CNC2=O 938-45-4 1-(2-HYDROXY-5-METHYLPHENYL)-1-PROPANON C10H12O2 164.20 CCC(=O)c1cc(C)ccc1O 87-24-1 2-METHYLBENZOICACIDETHYLESTER C10H12O2 164.20 CCOC(=O)c1ccccc1C 939-48-0 BENZOESAEURE-1-METHYLETHYLESTER C10H12O2 164.20 CC(C)OC(=O)c1ccccc1 527-17-3 2,3,5,6-TETRAMETHYL-2,5-CYCLOHEXADIEN-1,4-DION C10H12O2 164.20CC1=C(C)C(=O)C(C)=C(C)C1=O 579-60-2 2-methoxy-6-prop-2-enylphenol C10H12O2 164.20 COc1cccc(CC=C)c1O 2315-68-6 BENZOESAEUREPROPYLESTER C10H12O2 164.20 CCCOC(=O)c1ccccc1 1076-55-7 2-methoxy-6-(1-propenyl)phenol C10H12O2 164.20 COc1cccc(C=CC)c1O 97-53-0 2-METHOXY-4-(2-PROPENYL)-PHENOL C10H12O2 164.20 COc1cc(CC=C)ccc1O 528-90-5 2,4,5-TRIMETHYLBENZOESAEURE C10H12O2 164.20 OC(=O)c(cc1C)c(C)cc1C 3674-77-9 2-METHYL-2-PHENYL-1,3-DIOXOLAN C10H12O2 164.20 CC2(OCCO2)c1ccccc1 94-08-6 4-METHYLBENZOESAEUREETHYLESTER C10H12O2 164.20 CCOC(=O)c(cc1)ccc1C 97-54-1 2-METHOXY-4-(1-PROPENYL)PHENOL C10H12O2 164.20 COc1cc(C=CC)ccc1O 2438-05-3 4-PROPYLBENZOESAEURE C10H12O2 164.20 CCCc1ccc(C(O)=O)cc1 1076-88-6 3,4,5-TRIMETHYLBENZOESAEURE C10H12O2 164.20 OC(=O)c(cc1C)cc(C)c1C

Page 82 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 536-66-3 4-(1-METHYLETHYL)BENZOESAEURE C10H12O2 164.20 CC(C)c1ccc(C(O)=O)cc1 2437-66-3 2,3,5-TRIMETHYLBENZOESAEURE C10H12O2 164.20 OC(=O)c(cc(C)cc1C)c1C 877-53-2 2,4-dimethylphenylacetate C10H12O2 164.20 CC(=O)Oc1ccc(C)cc1C 5651-47-8 3-(1-METHYLETHYL)BENZOESAEURE C10H12O2 164.20 CC(C)c1cc(C(O)=O)ccc1 122-63-4 BENZYLPROPIONAT C10H12O2 164.20 CCC(OCc1ccccc1)=O 1076-47-7 2,3,4-TRIMETHYLBENZOESAEURE C10H12O2 164.20 OC(=O)c(ccc1C)c(C)c1C 772-01-0 2-phenyl-1,3-dioxane C10H12O2 164.20 C(CO2)COC2c1ccccc1 490-91-5 2-METHYL-5-(1-METHYLETHYL)-2,5-CYCLOHEXADIEN-1,4-DIONC10H12O2 164.20CC(C)C(=CC1=O)C(=O)C=C1C 480-63-7 2,4,6-TRIMETHYLBENZOESAEURE C10H12O2 164.20 OC(=O)c1c(C)cc(C)cc1C 103-25-3 3-PHENYLPROPIONSAEUREMETHYLESTER C10H12O2 164.20 COC(CCc1ccccc1)=O 103-45-7 ESSIGSAEURE-2-PHENYLETHYLESTER C10H12O2 164.20 CC(OCCc1ccccc1)=O 101-97-3 BENZOLESSIGSAEUREETHYLESTER C10H12O2 164.20 CCOC(=O)Cc1ccccc1 2438-04-2 2-(1-METHYLETHYL)BENZOESAEURE C10H12O2 164.20 CC(C)c1ccccc1C(O)=O 6380-23-0 4-ethenyl-1,2-dimethoxybenzene C10H12O2 164.20 COc1ccc(C=C)cc1OC 1821-12-1 BENZOLBUTANSAEURE C10H12O2 164.20 OC(CCCc1ccccc1)=O 90-27-7 a-ethylbenzeneaceticacid C10H12O2 164.20 CCC(C(O)=O)c1ccccc1 2529-36-4 2,3,6-TRIMETHYLBENZOESAEURE C10H12O2 164.20 OC(=O)c(c(C)ccc1C)c1C 5471-51-2 4-(4-hydroxyphenyl)butan-2-one C10H12O2 164.20 CC(CCc(cc1)ccc1O)=O 772-00-9 4-phenyl-1,3-dioxane C10H12O2 164.20 O(CO2)CCC2c1ccccc1 102-52-3 1,1,3,3-TETRAMETHOXYPROPAN C7H16O4 164.20 COC(OC)CC(OC)OC 122-84-9 4-METHOXYPHENYLACETON C10H12O2 164.20 COc1ccc(CC(C)=O)cc1 112-35-6 2-(2-(2-METHOXYETHOXY)ETHOXY)ETHANOL C7H16O4 164.20 COCCOCCOCCO 94-58-6 dihydrosafrole C10H12O2 164.20 CCCc2cc1OCOc1cc2 101-42-8 1,1-DIMETHYL-3-PHENYLHARNSTOFF C9H12N2O 164.21 CN(C)C(=O)Nc1ccccc1 78-67-1 2,2-AZO-BIS-ISOBUTYRONITRIL C8H12N4 164.21 CC(C)(C#N)N=NC(C)(C)C#N 3528-17-4 2,3-dihydro-4h-1-benzothiopyran-4-one C9H8OS 164.23 O=C2c1ccccc1SCC2 100-22-1 n,n,n',n'-tetramethyl-p-phenylenediamine C10H16N2 164.25 CN(C)c1ccc(N(C)C)cc1 588-67-0 BENZYL-N-BUTYLETHER C11H16O 164.25 CCCCOCc1ccccc1 2819-86-5 PENTAMETHYLPHENOL C11H16O 164.25 Oc1c(C)c(C)c(C)c(C)c1C 3280-08-8 a,a,b-trimethylbenzeneethanol C11H16O 164.25 OC(C)(C)C(C)c1ccccc1 10521-91-2 BENZOLPENTANOL C11H16O 164.25 OCCCCCc1ccccc1 705-73-7 1-phenylpentan-2-ol C11H16O 164.25 CCCC(O)Cc1ccccc1 103-05-9 2-METHYL-4-PHENYBUTAN-2-OL C11H16O 164.25 OC(C)(C)CCc1ccccc1 2219-82-1 2-METHYL-6-TERT.-BUTYLPHENOL C11H16O 164.25 CC(C)(C)c(cccc1C)c1O 98-27-1 2-METHYL-4-TERT.-BUTYLPHENOL C11H16O 164.25 CC(C)(C)c(ccc1O)cc1C 85688-95-5 ETHYL-(1,1-DIMETHYLPROPYL)-MALONSAEUREDINITRIL C10H16N2 164.25 CCC(C)(C)C(CC)(C#N)C#N 80-46-6 4-(1,1-DIMETHYLPROPYL)PHENOL C11H16O 164.25 CCC(C)(C)c(cc1)ccc1O 85688-96-6 METHYL-(1,1,2-TRIMETHYLPROPYL)-MALONSAEUREDINITRC10H16N2 164.25 CC(C)C(C)(C)C(C)(C#N)C#N 488-10-8 3-methyl-2-[(z)-pent-2-enyl]cyclopent-2-en-1-one C11H16O 164.25 CCC=CCC1=C(C)CCC1=O 93-05-0 n,n-diethyl-1,4-benzenediamine C10H16N2 164.25 CCN(CC)c(cc1)ccc1N 11050-62-7 2-methyl-3-[(e)-pent-2-enyl]cyclopent-2-en-1-one C11H16O 164.25 CCC=CCC(CCC1=O)=C1C 85688-81-9 MESO-2,3-DIETHYL-2,3-DIMETHYLBUTANDINITRIL C10H16N2 164.25 CCC(C)(C(C)(CC)C#N)C#N 2409-55-4 2-(1,1-DIMETHYLETHYL)-4-METHYLPHENOL C11H16O 164.25 CC(C)(C)c1cc(C)ccc1O 88-60-8 5-METHYL-2-TERT.-BUTYLPHENOL C11H16O 164.25 CC(C)(C)c1ccc(C)cc1O 704-01-8 n,n,n',n'-tetramethyl-1,2-benzenediamine C10H16N2 164.25 CN(C)c1ccccc1N(C)C 1076-56-8 4-ISOPROPYL-3-METHOXYTOLUOL C11H16O 164.25 COc1cc(C)ccc1C(C)C 998-30-1 TRIETHOXYSILAN C6H16O3Si 164.28 CCO[SiH](OCC)OCC 19740-34-2 2,2-DIMETHYLTRICYCLO(3.3.1.1(3,7))DECAN C12H20 164.29 CC3(C)C(CC2C1)CC1CC3C2 702-79-4 1,3-DIMETHYLTRICYCLO(3.3.1.1(3,7))DECAN C12H20 164.29CC2(C3)CC1(C)CC3CC(C2)C1 770-09-2 benzyltrimethylsilane C10H16Si 164.32 C[Si](C)(C)Cc1ccccc1 76-06-2 TRICHLORNITROMETHAN CCl3NO2 164.38 ClC(Cl)(Cl)N(=O)=O 507-47-1 chloralammonia C2H4Cl3NO 164.42 OC(N)C(Cl)(Cl)Cl 638-07-3 4-chloro-3-oxobutanoicacidethylester C6H9ClO3 164.59 CCOC(CC(CCl)=O)=O 431-27-6 1,2-dichloro-3,3,3-trifluoropropene C3HCl2F3 164.94 FC(F)(F)C(Cl)=CCl 76-38-0 2,2-DICHLOR-1,1-DIFLUOR-1-METHOXYETHAN C3H4Cl2F2O 164.97 COC(Cl)(Cl)C(F)F 1192-30-9 2-(BROMMETHYL)TETRAHYDROFURAN C5H9BrO 165.03 BrCC1CCCO1 4283-80-1 2-BROM-2-METHYLPENTAN C6H13Br 165.07 CCCC(C)(C)Br 626-88-0 1-BROM-4-METHYLPENTAN C6H13Br 165.07 BrCCCC(C)C 3377-86-4 2-BROMHEXAN C6H13Br 165.07 CCCCC(C)Br 111-25-1 1-HEXYLBROMID C6H13Br 165.07 CCCCCCBr 3377-87-5 3-BROMHEXAN C6H13Br 165.07 CCCC(Br)CC 100-19-6 4-NITROACETOPHENONE C8H7NO3 165.15 CC(=O)c1ccc(cc1)N(=O)=O

Page 83 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 121-89-1 1-(3-NITROPHENYL)ETHANON C8H7NO3 165.15 CC(=O)c1cc(ccc1)N(=O)=O 577-59-3 1-(2-NITROPHENYL)ETHANON C8H7NO3 165.15 CC(=O)c1ccccc1N(=O)=O 500-72-1 oxo(phenylamino)aceticacid C8H7NO3 165.15 OC(=O)C(=O)Nc1ccccc1 578-76-7 2-amino-1,7-dihydro-7-methyl-6h-purin-6-one C6H7N5O 165.15 Cn1cnc2NC(N)=NC(c21)=O 85-91-6 2-(METHYLAMINO)BENZOESAEUREMETHYLESTER C9H11NO2 165.19 COC(=O)c1ccccc1NC 87-25-2 ANTHRANILSAEUREETHYLESTER C9H11NO2 165.19 CCOC(=O)c1ccccc1N 101-99-5 PHENYLCARBAMIDSAEUREETHYLESTER C9H11NO2 165.19 CCOC(=O)Nc1ccccc1 619-84-1 4-(DIMETHYLAMINO)BENZOESAEURE C9H11NO2 165.19 CN(C)c1ccc(C(O)=O)cc1 1129-41-5 METHYLCARBAMIDSAEURE-3-METHYLPHENYLESTER C9H11NO2 165.19 Cc1cc(OC(=O)NC)ccc1 582-33-2 3-amino-benzoicacidethylester C9H11NO2 165.19 CCOC(=O)c(ccc1)cc1N 886-86-2 tricaine C9H11NO2 165.19 CCOC(=O)c(ccc1)cc1N 94-09-7 4-AMINOBENZOESAEUREETHYLESTER C9H11NO2 165.19 CCOC(=O)c(cc1)ccc1N 51-66-1 4-ACETANISIDIN C9H11NO2 165.19 COc1ccc(cc1)NC(C)=O 93-26-5 o-methoxyacetanilide C9H11NO2 165.19 COc1ccccc1NC(C)=O 603-71-4 1,3,5-TRIMETHYL-2-NITROBENZOL C9H11NO2 165.19 Cc(cc1C)cc(C)c1N(=O)=O 938-73-8 2-ethoxybenzamide C9H11NO2 165.19 CCOc1ccccc1C(=O)N 610-16-2 2-(dimethylamino)benzoicacid C9H11NO2 165.19 C[NH+](C)c1ccccc1C([O-])=O 614-19-7 3-amino-3-phenylpropanoicacid C9H11NO2 165.19 NC(CC(O)=O)c1ccccc1 63-91-2 L-PHENYLALANIN C9H11NO2 165.19[NH3+]C(Cc1ccccc1)C([O-])=O 2284-20-0 1-isothiocyanato-4-methoxybenzene C8H7NOS 165.21 COc1ccc(cc1)N=C=S 370-14-9 4-[2-(methylamino)propyl]-phenol C10H15NO 165.23 CNC(C)Cc(cc1)ccc1O 539-15-1 hordenine C10H15NO 165.23 CN(C)CCc(cc1)ccc1O 92-50-2 2-(ethylphenylamino)ethanol C10H15NO 165.23 OCCN(CC)c1ccccc1 91-68-9 3-DIETHYLAMINOPHENOL C10H15NO 165.23 CCN(CC)c(ccc1)cc1O 299-42-3 EPHEDRIN C10H15NO 165.23 CNC(C)C(O)c1ccccc1 15482-60-7 N,N-DIMETHYLBENZOLCARBOTHIOAMID C9H11NS 165.26 CN(C)C(c1ccccc1)=S 353-59-3 BROMCHLORDIFLUORMETHAN CBrClF2 165.36 FC(F)(Cl)Br 302-17-0 1,1-DIHYDROXY-3,3,3-TRICHLORETHAN C2H3Cl3O2 165.40 OC(O)C(Cl)(Cl)Cl 127-18-4 TETRACHLORETHEN C2Cl4 165.83 ClC(Cl)=C(Cl)Cl 7791-23-3 SELENOXYDICHLORID Cl2OSe 165.87 Cl[Se](Cl)=O 659-86-9 3-iodo-1-propyne C3H3I 165.96 ICC#C 684-16-2 PERFLUORACETON C3F6O 166.02 FC(F)(F)C(C(F)(F)F)=O 1187-93-5 3-OXAPERFLUORBUTEN C3F6O 166.02 FC(F)(F)OC(F)=C(F)F 7791-49-3 5-methoxybenzofurazan,1-oxide C7H6N2O3 166.13 COc(ccc1n2=O)cc1no2 88-99-3 1,2-BENZOLDICARBONSAEURE C8H6O4 166.13 OC(=O)c1ccccc1C(O)=O 94-53-1 1,3-benzodioxole-5-carboxylicacid C8H6O4 166.13 OC(=O)c2cc1OCOc1cc2 121-91-5 1,3-BENZOLDICARBONSAEURE C8H6O4 166.13 OC(=O)c1cc(C(O)=O)ccc1 100-21-0 1,4-BENZOLDICARBONSAEURE C8H6O4 166.13 OC(=O)c1ccc(C(O)=O)cc1 1129-37-9 p-nitrobenzaldoxime C7H6N2O3 166.13 ON=Cc1ccc(cc1)N(=O)=O 645-09-0 3-nitrobenzamide C7H6N2O3 166.13 O=N(=O)c1cc(ccc1)C(=O)N 619-80-7 4-nitrobenzamide C7H6N2O3 166.13 O=N(=O)c1ccc(cc1)C(=O)N 610-15-1 2-nitrobenzamide C7H6N2O3 166.13 O=N(=O)c1ccccc1C(=O)N 122-52-1 TRIETHYLPHOSPHIT C6H15O3P 166.16 CCOP(OCC)OCC 78-38-6 DIETHYL-ETHYLPHOSPHONAT C6H15O3P 166.16 CCOP(CC)(OCC)=O 118-61-6 2-HYDROXYBENZOESAEUREETHYLESTER C9H10O3 166.17 CCOC(=O)c1ccccc1O 3878-46-4 ethyl-phenyl-carbonate C9H10O3 166.17 CCOC(=O)Oc1ccccc1 35438-82-5 cis,cis-3-methyl-4-cyclohexene-1,2-dicarboxylicac C9H10O3 166.17 CC1C=CCC2C1C(OC2=O)=O 613-70-7 2-ACETOXYANISOL C9H10O3 166.17 COc1ccccc1OC(C)=O 552-41-0 2-hydroxy-4-methoxy-acetophenon C9H10O3 166.17 COc(ccc1C(C)=O)cc1O 619-86-3 4-ETHOXYBENZOESAEURE C9H10O3 166.17 CCOc1ccc(C(O)=O)cc1 120-47-8 4-HYDROXYBENZOESAEUREETHYLESTER C9H10O3 166.17 CCOC(=O)c(cc1)ccc1O 121-98-2 4-METHOXYBENZOESAEUREMETHYLESTER C9H10O3 166.17 COC(=O)c(cc1)ccc1OC 621-51-2 3-ethoxybenzoicacid C9H10O3 166.17 CCOc1cc(C(O)=O)ccc1 2065-23-8 PHENOXYESSIGSAEUREMETHYLESTER C9H10O3 166.17 COC(COc1ccccc1)=O 121-32-4 3-ETHOXY-4-HYDROXYBENZALDEHYD C9H10O3 166.17 CCOc1cc(C=O)ccc1O 529-64-6 tropicacid C9H10O3 166.17 OCC(C(O)=O)c1ccccc1 498-02-2 4-HYDROXY-3-METHOXYACETOPHENON C9H10O3 166.17 COc1cc(C(C)=O)ccc1O 93-25-4 2-METHOXYPHENYLESSIGSAEURE C9H10O3 166.17 COc1ccccc1CC(O)=O 93-02-7 2,5-DIMETHOXYBENZALDEHYD C9H10O3 166.17 COc(ccc1OC)cc1C=O 104-01-8 4-METHOXYPHENYLESSIGSAEURE C9H10O3 166.17 COc1ccc(CC(O)=O)cc1 940-64-7 p-methylphenoxyaceticacid C9H10O3 166.17 OC(COc(cc1)ccc1C)=O 1798-09-0 3-METHOXYPHENYLESSIGSAEURE C9H10O3 166.17 COc1cc(CC(O)=O)ccc1

Page 84 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 515-30-0 a-hydroxy-a-methylbenzeneaceticacid C9H10O3 166.17 OC(C)(C(O)=O)c1ccccc1 94-33-7 BENZOESAEURE(2-HYDROXYETHYL)ESTER C9H10O3 166.17 OCCOC(=O)c1ccccc1 606-45-1 2-METHOXYBENZOESAEUREMETHYLESTER C9H10O3 166.17 COC(=O)c1ccccc1OC 134-11-2 2-ethoxybenzoicacid C9H10O3 166.17 CCOc1ccccc1C(O)=O 613-45-6 2,4-dimethoxybenzaldehyd C9H10O3 166.17 COc(ccc1C=O)cc1OC 120-14-9 3,4-DIMETHOXYBENZALDEHYD C9H10O3 166.17 COc1ccc(C=O)cc1OC 501-97-3 4-HYDROXYBENZOLPROPANSAEURE C9H10O3 166.17 OC(CCc(cc1)ccc1O)=O 619-31-8 3-NITRO-N,N-DIMETHYLANILIN C8H10N2O2 166.18 CN(C)c1cc(ccc1)N(=O)=O 610-17-3 N,N-DIMETHYL-2-NITROBENZOLAMIN C8H10N2O2 166.18 CN(C)c1ccccc1N(=O)=O 3665-80-3 n-ethyl-4-nitrobenzenamine C8H10N2O2 166.18 CCNc1ccc(cc1)N(=O)=O 100-23-2 N,N-DIMETHYL-4-NITROBENZOLAMIN C8H10N2O2 166.18 CN(C)c1ccc(cc1)N(=O)=O 66215-27-8 n2-cyclopropyl-1,3,5-triazine-2,4,6-triamine C6H10N6 166.18 Nc2nc(NC1CC1)nc(N)n2 825-44-5 benzothiophene-1,1-dioxide C8H6O2S 166.20 O=S2(=O)C=Cc1ccccc21 2785-87-7 2-METHOXY-4-PROPYLPHENOL C10H14O2 166.22 CCCc(ccc1O)cc1OC 122-95-2 1,4-diethoxybenzene C10H14O2 166.22 CCOc1ccc(OCC)cc1 24168-70-5 2-butan-2-yl-3-methoxypyrazine C9H14N2O 166.22 CCC(C)c1nccnc1OC 72797-16-1 2-ethoxy-3-propan-2-ylpyrazine C9H14N2O 166.22 CCOc1nccnc1C(C)C 553-84-4 1-(3-FURANYL)-4-METHYL-1-PENTANON C10H14O2 166.22 CC(C)CCC(=O)c1cocc1 14360-50-0 1-furan-2-ylhexan-1-one C10H14O2 166.22 CCCCCC(=O)c1occc1 99172-63-1 4-PHENYLBUTYLHYDROPEROXIDE C10H14O2 166.22 OOCCCCc1ccccc1 122-94-1 4-BUTOXYPHENOL C10H14O2 166.22 CCCCOc(cc1)ccc1O 2050-46-6 1,2-diethoxybenzene C10H14O2 166.22 CCOc1ccccc1OCC 24683-00-9 2-methoxy-3-(2-methylpropyl)pyrazine C9H14N2O 166.22 CC(C)Cc1nccnc1OC 527-18-4 2,3,5,6-tetramethyl-1,4-benzenediol C10H14O2 166.22 Oc1c(C)c(C)c(O)c(C)c1C 490-06-2 3-METHYL-6-(1-METHYLETHYL)-1,2-BENZOLDIOL C10H14O2 166.22 CC(C)c(ccc1C)c(O)c1O 13341-72-5 3,6-dimethyl-5,6,7,7a-tetrahydro-4h-1-benzofuran-2-one C10H14O2 166.22 CC(CCC1=C2C)CC1OC2=O 98-29-3 4-(1,1-DIMETHYLETHYL)-1,2-BENZOLDIOL C10H14O2 166.22 CC(C)(C)c(ccc1O)cc1O 1948-33-0 2-(1,1-DIMETHYLETHYL)-1,4-BENZOLDIOL C10H14O2 166.22 CC(C)(C)c1cc(O)ccc1O 86-73-7 9H-FLUOREN C13H10 166.22 C(c2cc3)c1ccccc1c2cc3 614-78-8 (2-methylphenyl)thiourea C8H10N2S 166.24 Cc1ccccc1NC(N)=S 536-33-4 ethionamide C8H10N2S 166.24 CCc1cc(ccn1)C(N)=S 472-66-2 2-(2,6,6-trimethyl-1-cyclohexenyl)acetaldehyde C11H18O 166.26 CC1(C)CCCC(C)=C1CC=O 1128-08-1 3-methyl-2-pentylcyclopent-2-en-1-one C11H18O 166.26 CCCCCC1=C(C)CCC1=O 492-97-7 2,2-BITHIOPHEN C8H6S2 166.26 c(csc1c2sccc2)c1 3777-71-7 2-heptylfuran C11H18O 166.26 CCCCCCCc1occc1 13132-25-7 P-TRIMETHYLSILYLPHENOL C9H14OSi 166.29 C[Si](C)(C)c(cc1)ccc1O 1529-17-5 TRIMETHYLPHENOXYSILAN C9H14OSi 166.29 C[Si](C)(C)Oc1ccccc1 765-03-7 1-DODECIN C12H22 166.30 CCCCCCCCCCC#C 92-51-3 BICYCLOHEXYL C12H22 166.30 C(CC1)CCC1C2CCCCC2 1118-15-6 1,3-disiloxanediol,1,1,3,3-tetramethyl- C4H14O3Si2 166.32 O[Si](C)(C)O[Si](O)(C)C 2804-50-4 2-chloro-1,1,3,3,3-pentafluoro-1-propene C3ClF5 166.48 FC(F)(F)C(Cl)=C(F)F 102-92-1 3-PHENYL-2-PROPENOYLCHLORID C9H7ClO 166.61 ClC(=O)C=Cc1ccccc1 624-75-9 iodoacetonitrile C2H2IN 166.95 ICC#N 105-36-2 ETHYLBROMACETAT C4H7BrO2 167.00 CCOC(CBr)=O 927-68-4 2-bromoethanolacetate C4H7BrO2 167.00 BrCCOC(C)=O 2052-01-9 2-bromo-2-methylpropanoicacid C4H7BrO2 167.00 CC(C)(Br)C(O)=O 80-58-0 .ALPHA.-BROMBUTTERSAEURE C4H7BrO2 167.00 CCC(Br)C(O)=O 3011-34-5 4-formyl-2-nitrophenol C7H5NO4 167.12 Oc1ccc(C=O)cc1N(=O)=O 1874-22-2 3-(5-nitro-2-furyl)-2-propenal C7H5NO4 167.12 O=N(=O)c1oc(cc1)C=CC=O 121-92-6 3-NITROBENZOESAEURE C7H5NO4 167.12 OC(=O)c1cc(ccc1)N(=O)=O 62-23-7 4-NITROBENZOESAEURE C7H5NO4 167.12 OC(=O)c1ccc(cc1)N(=O)=O 552-16-9 2-NITROBENZOESAEURE C7H5NO4 167.12 OC(=O)c1ccccc1N(=O)=O 499-81-0 dinicotinicacid C7H5NO4 167.12 OC(=O)c1cc(C(O)=O)cnc1 499-80-9 2,4-PYRIDINDICARBONSAEURE C7H5NO4 167.12 OC(=O)c1cc(C(O)=O)ccn1 100-26-5 ISOCINCHOMERONICACID C7H5NO4 167.12 OC(=O)c1ccc(C(O)=O)cn1 499-83-2 2,6-PYRIDINDICARBONSAEURE C7H5NO4 167.12 OC(=O)c1nc(C(O)=O)ccc1 490-11-9 cinchomeronicacid C7H5NO4 167.12 OC(=O)c1cnccc1C(O)=O 89-00-9 quinolinicacid C7H5NO4 167.12 OC(=O)c1ncccc1C(O)=O 18243-41-9 (BROMMETHYL)-TRIMETHYLSILAN C4H11BrSi 167.12 BrC[Si](C)(C)C 86-74-8 CARBAZOL C12H9N 167.21 c(ccc1c2ccccc2[nH]3)cc31 244-99-5 5H-INDENO(1,2-B)PYRIDIN C12H9N 167.21 C(c2cc3)c1ccccc1c2nc3 149-30-4 MERCAPTOBENZOTHIAZOL C7H5NS2 167.25 Sc2sc1ccccc1n2

Page 85 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 79-34-5 1,1,2,2-TETRACHLORETHAN C2H2Cl4 167.85 ClC(Cl)C(Cl)Cl 630-20-6 1,1,1,2-TETRACHLORETHAN C2H2Cl4 167.85 ClCC(Cl)(Cl)Cl 920-66-1 1,1,1,3,3,3-HEXAFLUOR-2-PROPANOL C3H2F6O 168.04 FC(F)(F)C(O)C(F)(F)F 99-65-0 1,3-DINITROBENZOL C6H4N2O4 168.11 O=N(=O)c1cc(ccc1)N(=O)=O 100-25-4 1,4-DINITROBENZOL C6H4N2O4 168.11 O=N(=O)c1ccc(cc1)N(=O)=O 528-29-0 1,2-DINITROBENZOL C6H4N2O4 168.11 O=N(=O)c1ccccc1N(=O)=O 121-34-6 4-HYDROXY-3-METHOXYBENZOESAEURE C8H8O4 168.15 COc1cc(C(O)=O)ccc1O 78508-45-9 (4-fluoro-3-methylphenyl)-urea C8H9FN2O 168.17 Fc1ccc(cc1C)NC(=O)N 822-06-0 1,6-HEXAMETHYLENDIISOCYANAT C8H12N2O2 168.19 O=C=NCCCCCCN=C=O 6638-05-7 2,6-dimethoxy-4-methylphenol C9H12O3 168.19 COc1cc(C)cc(OC)c1O 634-36-6 1,2,3-TRIMETHOXYBENZOL C9H12O3 168.19 COc1cccc(OC)c1OC 31703-08-9 5-ETHYL-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINDION C8H12N2O2 168.19 CCc1cn(C)c(=O)n(C)c1=O 132-64-9 DIBENZOFURAN C12H8O 168.19 c(ccc2c1ccccc1o3)cc32 5535-48-8 (ETHENYLSULFONYL)-BENZOL C8H8O2S 168.21 C=CS(c1ccccc1)(=O)=O 101-81-5 DIPHENYLMETHAN C13H12 168.24 C(c2ccccc2)c1ccccc1 644-08-6 4-METHYLBIPHENYL C13H12 168.24 Cc2ccc(cc2)c1ccccc1 112-45-8 undec-10-enal C11H20O 168.28 O=CCCCCCCCCC=C 36219-73-5 undec-10-en-2-one C11H20O 168.28 CC(CCCCCCCC=C)=O 18794-77-9 2-HEXYLTHIOPHEN C10H16S 168.30 CCCCCCc1sccc1 7206-26-0 (2Z)-2-DODECEN C12H24 168.32 CCCCCCCCCC=CC 112-41-4 1-DODECEN C12H24 168.32 CCCCCCCCCCC=C 7206-13-5 (2E)-2-DODECEN C12H24 168.32 CCCCCCCCCC=CC 27656-49-1 (3E)-2,2,4,6,6-PENTAMETHYL-3-HEPTEN C12H24 168.32 CC(C)(C)CC(C)=CC(C)(C)C 294-62-2 CYCLODODECAN C12H24 168.32 C1CCCCCCCCCCC1 5617-42-5 HEPTYLCYCLOPENTAN C12H24 168.32 CCCCCCCC1CCCC1 704-73-4 n-methyl-2-fluorophenylcarbamate C8H8FNO2 169.15 Fc1ccccc1OC(=O)NC 705-48-6 n-methyl-3-fluorophenylcarbamate C8H8FNO2 169.15 Fc1cc(OC(=O)NC)ccc1 705-70-4 n-methyl-4-fluorophenylcarbamate C8H8FNO2 169.15 Fc1ccc(OC(=O)NC)cc1 65-23-6 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol C8H11NO3 169.18 OCc(cnc1C)c(CO)c1O 14885-29-1 1-METHYL-2-(1-METHYLETHYL)-5-NITRO-1H-IMIDAZOL C7H11N3O2 169.18 CC(C)c1ncc(n1C)N(=O)=O 122-39-4 N-PHENYLBENZOLAMIN C12H11N 169.22 N(c2ccccc2)c1ccccc1 92-67-1 4-AMINOBIPHENYL C12H11N 169.22 Nc2ccc(cc2)c1ccccc1 53498-32-1 4,5-dimethyl-2-(2-methylpropyl)-1,3-thiazole C9H15NS 169.29 CC(C)Cc(nc1C)sc1C 354-21-2 1,2,2-TRICHLOR-1,1-DIFLUORETHAN C2HCl3F2 169.39 ClC(Cl)C(F)(F)Cl 3982-91-0 THIOPHOSPHORYLCHLORID Cl3PS 169.40 ClP(Cl)(Cl)=S 588-07-8 N-(3-CHLORPHENYL)ACETAMID C8H8ClNO 169.61 Clc1cc(ccc1)NC(C)=O 539-03-7 N-(4-CHLORPHENYL)ACETAMID C8H8ClNO 169.61 Clc1ccc(cc1)NC(C)=O 533-17-5 N-(2-CHLORPHENYL)ACETAMID C8H8ClNO 169.61 Clc1ccccc1NC(C)=O 10026-04-7 SILICIUMTETRACHLORID Cl4Si 169.90 Cl[Si](Cl)(Cl)Cl 506-80-9 CARBONDISELENID CSe2 169.94 [Se]=C=[Se] 75-30-9 2-IODPROPAN C3H7I 169.99 CC(C)I 107-08-4 1-PROPYLIODID C3H7I 169.99 CCCI 431-89-0 1,1,1,2,3,3,3-HEPTAFLUORPROPAN C3HF7 170.03 FC(F)(F)C(F)C(F)(F)F 371-78-8 THIOBIS(TRIFLUORMETHAN) C2F6S 170.08 FC(F)(F)SC(F)(F)F 149-91-7 3,4,5-TRIHYDROXYBENZOESAEURE C7H6O5 170.12 OC(=O)c(cc1O)cc(O)c1O 2274-11-5 2-PROPENSAEURE-1,2-ETHANDIYLESTER C8H10O4 170.16 C=CC(OCCOC(=O)C=C)=O 4166-20-5 (2,5-dimethyl-4-oxofuran-3-yl) acetate C8H10O4 170.16CC(=O)OC(=C(C)OC1C)C1=O 90-43-7 2-PHENYLPHENOL C12H10O 170.21 Oc2ccccc2c1ccccc1 941-98-0 1-ACETYLNAPHTHALIN C12H10O 170.21 CC(=O)c2c1ccccc1ccc2 93-08-3 1-(2-NAPHTHALINYL)ETHANON C12H10O 170.21 CC(=O)c2cc1ccccc1cc2 580-51-8 [1,1'-biphenyl]-3-ol C12H10O 170.21 Oc2cc(ccc2)c1ccccc1 92-69-3 4-PHENYLPHENOL C12H10O 170.21 Oc2ccc(cc2)c1ccccc1 101-84-8 DIPHENYLETHER C12H10O 170.21 O(c2ccccc2)c1ccccc1 3185-99-7 METHYL-PARA-TOLYLSULFON C8H10O2S 170.23 Cc1ccc(cc1)S(C)(=O)=O 3112-90-1 BENZYLMETHYLSULFON C8H10O2S 170.23 CS(Cc1ccccc1)(=O)=O 334-49-6 dec-2-enoic acid C10H18O2 170.25 CCCCCCCC=CC(O)=O 14436-32-9 9-DECENSAEURE C10H18O2 170.25 OC(CCCCCCCC=C)=O 502-47-6 3,7-DIMETHYL-6-OCTENSAEURE C10H18O2 170.25 CC(CCC=C(C)C)CC(O)=O 1946-00-5 1-methyl-4-prop-1-en-2-ylcyclohexane-1,2-diol C10H18O2 170.25 OC1CC(CCC1(O)C)C(C)=C 7367-82-0 ethyl (e)-oct-2-enoate C10H18O2 170.25 CCCCCC=CC(OCC)=O 706-14-9 5-HEXYLDIHYDRO-2(3H)-FURANON C10H18O2 170.25 CCCCCCC1OC(CC1)=O 5579-78-2 7-butyloxepan-2-one C10H18O2 170.25 CCCCC1OC(CCCC1)=O

Page 86 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 705-86-2 TETRAHYDRO-6-PENTYL-2H-PYRAN-2-ON C10H18O2 170.25 CCCCCC1OC(CCC1)=O 2131-41-1 1,4,5-TRIMETHYLNAPHTHALIN C13H14 170.25 Cc2ccc(C)c1c2cccc1C 2765-18-6 1-PROPYLNAPHTHALIN C13H14 170.25 CCCc2c1ccccc1ccc2 927-49-1 6-UNDECANON C11H22O 170.29 CCCCCC(CCCCC)=O 112-12-9 2-UNDECANON C11H22O 170.29 CCCCCCCCCC(C)=O 112-44-7 UNDECANAL C11H22O 170.29 CCCCCCCCCCC=O 699-10-5 methyldisulfanylmethylbenzene C8H10S2 170.30 CSSCc1ccccc1 13475-82-6 2,2,4,6,6-PENTAMETHYLHEPTAN C12H26 170.34 CC(CC(C)(C)C)CC(C)(C)C 7045-71-8 2-METHYLUNDECAN C12H26 170.34 CCCCCCCCCC(C)C 1002-43-3 3-METHYLUNDECAN C12H26 170.34 CCCCCCCCC(C)CC 112-40-3 DODECAN C12H26 170.34 CCCCCCCCCCCC 14630-40-1 silane,1,2-ethynediylbis[trimethyl- C8H18Si2 170.40 C[Si](C)(C)C#C[Si](C)(C)C 17348-69-5 5-chloro-beznofurazanoxide C6H3ClN2O2 170.55 Clc2cc1non(=O)c1cc2 114-38-5 2-chlorophenylurea C7H7ClN2O 170.60 Clc1ccccc1NC(=O)N 1967-27-7 (3-chlorophenyl)urea C7H7ClN2O 170.60 Clc1cc(ccc1)NC(=O)N 768-33-2 CHLORDIMETHYLPHENYLSILAN C8H11ClSi 170.71 C[Si](C)(Cl)c1ccccc1 374-07-2 1,1-DICHLOR-1,2,2,2-TETRAFLUORETHAN C2Cl2F4 170.92 FC(F)(F)C(F)(Cl)Cl 76-14-2 1,2-DICHLOR-1,1,2,2-TETRAFLUORETHAN C2Cl2F4 170.92 FC(F)(Cl)C(F)(F)Cl 106-38-7 1-BROM-4-METHYLBENZOL C7H7Br 171.04 Cc1ccc(Br)cc1 591-17-3 1-BROM-3-METHYLBENZOL C7H7Br 171.04 Cc1cc(Br)ccc1 108-60-1 2,2`-DICHLORDIISOPROPYLETHER C6H12Cl2O 171.07 ClCC(C)OC(C)CCl 383-70-0 N-(TRIFLUORACETYL)-AMINOESSIGSAEURE C4H4F3NO3 171.08 OC(=O)CNC(C(F)(F)F)=O 4346-64-9 phenylmethylselenide C7H8Se 171.10 C[Se]c1ccccc1 1874-23-3 5-nitro-2-furancarboxylicacidmethylester C6H5NO5 171.11 COC(=O)c1oc(cc1)N(=O)=O 10605-40-0 (3-chloropropyl)dimethylchlorosilane C5H12Cl2Si 171.14 ClCCC[Si](C)(C)Cl 827-16-7 1,3,5-TRIMETHYL-1,3,5-TRIAZINE-2,4-6(1H,3H,5H)-TRION C6H9N3O3 171.15CN1C(=O)N(C)C(=O)N(C)C1=O 877-89-4 2,4,6-TRIMETHOXY-1,3,5-TRIAZIN C6H9N3O3 171.15 COc1nc(OC)nc(OC)n1 702-54-5 diethadione C8H13NO3 171.19 CCC1(CC)COC(=O)NC1=O 5183-78-8 N-METHYLBENZOLSULFONAMID C7H9NO2S 171.22 CNS(c1ccccc1)(=O)=O 70-55-3 P-TOLUOLSULFONSAEUREAMID C7H9NO2S 171.22 Cc1ccc(cc1)S(=O)(=O)N 2319-29-1 DECANAMID C10H21NO 171.28 CCCCCCCCCC(=O)N 51115-67-4 n,2,3-trimethyl-2-propan-2-ylbutanamide C10H21NO 171.28 CC(C)C(C)(C(C)C)C(=O)NC 65894-82-8 2-butan-2-yl-4,5-dimethyl-2,5-dihydro-1,3-thiazole C9H17NS 171.30 CCC(C)C(SC1C)N=C1C 65894-83-9 4,5-dimethyl-2-(2-methylpropyl)-2,5-dihydro-1,3-thiazole C9H17NS 171.30 CC(C)CC(SC1C)N=C1C 7307-55-3 1-UNDECANAMIN C11H25N 171.32 NCCCCCCCCCCC 1194-65-6 2,6-DICHLORBENZONITRIL C7H3Cl2N 172.01 Clc1cccc(Cl)c1C#N 106-40-1 4-BROMBENZOLAMIN C6H6BrN 172.02 Nc1ccc(Br)cc1 141-05-9 (2Z)-2-BUTENDISAEUREDIETHYLESTER C8H12O4 172.18 CCOC(=O)C=CC(OCC)=O 34524-96-4 2-methylnaphthalene-1,4-dione C11H8O2 172.18 CC2=CC(c1ccccc1C2=O)=O 93-09-4 2-NAPHTHALINCARBONSAEURE C11H8O2 172.18 OC(=O)c2cc1ccccc1cc2 86-55-5 1-NAPHTHALINCARBONSAEURE C11H8O2 172.18 OC(=O)c2c1ccccc1ccc2 619-82-9 1,4-CYCLOHEXANEDICARBOXYLICACID,TRANS- C8H12O4 172.18 OC(C1CCC(CC1)C(O)=O)=O 104-15-4 4-TOLUOLSULFONSAEURE C7H8O3S 172.20 Cc1ccc(cc1)S(O)(=O)=O 88-20-0 2-TOLUOLSULFONSAEURE C7H8O3S 172.20 Cc1ccccc1S(O)(=O)=O 16624-68-3 N-ACETYL-L-LEUCINAMID C8H16N2O2 172.23 CC(C)CC(NC(C)=O)C(=O)N 106-32-1 OCTANSAEUREETHYLESTER C10H20O2 172.27 CCCCCCCC(OCC)=O 103-09-3 ESSIGSAEURE-2-ETHYLHEXYLESTER C10H20O2 172.27 CCCCC(CC)COC(C)=O 659-70-1 3-METHYLBUTANSAEURE-3-METHYLBUTYLESTER C10H20O2 172.27 CC(C)CCOC(CC(C)C)=O 112-14-1 ESSIGSAEUREOCTYLESTER C10H20O2 172.27 CCCCCCCCOC(C)=O 1670-47-9 1,1-diethoxycyclohexane C10H20O2 172.27 CCOC1(OCC)CCCCC1 80-53-5 aa-4-hydroxy-4-trimethylcyclohexanemethanol C10H20O2 172.27 OC1(C)CCC(CC1)C(O)(C)C 2451-01-6 terpinhydrate C10H20O2 172.27 OC1(C)CCC(CC1)C(O)(C)C 42822-86-6 2-(2-hydroxypropan-2-yl)-5-methylcyclohexan-1-ol C10H20O2 172.27 CC(CCC1C(O)(C)C)CC1O 334-48-5 DECANSAEURE C10H20O2 172.27 CCCCCCCCCC(O)=O 565-48-0 CYCLOHEXANEMETHANOL,4-HYDROXY-ALPHA,ALPHA,4-TRIMETHYL,CISC10H20O2 172.27 OC1(C)CCC(CC1)C(O)(C)C 565-50-4 CYCLOHEXANEMETHANOL,4-HYDROXY-ALPHA,ALPHA,4-TRIMETHYL,TRANSC10H20O2 172.27 OC1(C)CCC(CC1)C(O)(C)C 5451-92-3 AMEISENSAEURENONYLESTER C10H20O2 172.27 CCCCCCCCCOC=O 5336-24-3 1,3-BIS-(1,1-DIMETHYLETHYL)-HARNSTOFF C9H20N2O 172.27 CC(C)(C)NC(=O)NC(C)(C)C 107-75-5 HYDROXYCITRONELLAL C10H20O2 172.27 OC(C)(C)CCCC(C)CC=O 80-47-7 HYDROPEROXIDE,1-METHYL-1-(4METHYLCYCLOHEXYL)ETHYLC10H20O2 172.27 OOC(C)(C)C(CC1)CCC1C 1187-03-7 TETRAETHYLHARNSTOFF C9H20N2O 172.27 CCN(CC)C(=O)N(CC)CC 4062-60-6 1,2-ETHANEDIAMINE,N,N-BIS(1,1-DIMETHYLETHYL)- C10H24N2 172.31 CC(C)(C)NCCNC(C)(C)C

Page 87 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 1653-30-1 2-UNDECANOL C11H24O 172.31 CCCCCCCCCC(O)C 112-42-5 1-UNDECANOL C11H24O 172.31 OCCCCCCCCCCC 74356-31-3 2,4-dimethylnonan-4-ol C11H24O 172.31 CCCCCC(O)(C)CC(C)C 40934-68-7 DIMETHYLOCTYLSILAN C10H24Si 172.38 CCCCCCCC[SiH](C)C 95-56-7 2-BROMPHENOL C6H5BrO 173.01 Oc1ccccc1Br 106-41-2 4-BROMPHENOL C6H5BrO 173.01 Oc1ccc(Br)cc1 591-20-8 3-BROMPHENOL C6H5BrO 173.01 Oc1cc(Br)ccc1 111-91-1 BIS-(2-CHLORETHOXY)-METHAN C5H10Cl2O2 173.04 ClCCOCOCCCl 86-57-7 1-NITRONAPHTHALIN C10H7NO2 173.17 O=N(=O)c2c1ccccc1ccc2 132-53-6 2-NITROSO-1-NAPHTOL C10H7NO2 173.17 ON=C2C=Cc1ccccc1C2=O 131-91-9 1-NITROSO-2-NAPHTHALENOL C10H7NO2 173.17 ON=C2c1ccccc1C=CC2=O 605-60-7 4-NITROSO-1-NAPHTHALENOL C10H7NO2 173.17 Oc2c1ccccc1c(N=O)cc2 121-57-3 4-AMINOBENZOLSULFONSAEURE C6H7NO3S 173.19[NH3+]c1ccc(cc1)S(=O)([O-])=O 3637-10-3 2,2,6,6-TETRAMETHYL-1,4-PIPERIDINDIOL C9H19NO2 173.25 OC(CC1(C)C)CC(C)(C)N1O 74-95-3 DIBROMMETHAN CH2Br2 173.83 BrCBr 13980-04-6 hexahydro-1,3,5-trinitroso-1,3,5-triazine C3H6N6O3 174.12 O=NN1CN(CN(C1)N=O)N=O 584-84-9 2,4-DIISOCYANATO-1-METHYLBENZOL C9H6N2O2 174.16 Cc1ccc(N=C=O)cc1N=C=O 91-08-7 2,6-TOLUOLDIISOCYANAT C9H6N2O2 174.16 Cc1c(cccc1N=C=O)N=C=O 505-48-6 1,8-OCTANDISAEURE C8H14O4 174.20 OC(CCCCCCC(O)=O)=O 3491-36-9 (1,1,4,4-TETRAMETHYL-2-BUTYNE-1,4-DIYL)BIS(HYDROPEROXID)C8H14O4 174.20 OOC(C)(C)C#CC(C)(C)OO 123-25-1 BUTANDISAEUREDIETHYLESTER C8H14O4 174.20 CCOC(CCC(OCC)=O)=O 828-00-2 1,3-DIOXAN-4-OL,2,6-DIMETHYL-,ACETATE C8H14O4 174.20 CC1OC(CC(C)O1)OC(C)=O 74-79-3 l-arginine C6H14N4O2 174.20NC(CCCNC(=[NH2+])N)C([O-])=O 82554-97-0 trans-di-tert-butylhyponitrite C8H18N2O2 174.24 CC(C)(C)ON=NOC(C)(C)C 3682-91-5 4-HEPTANONE,2,6-DIHYDROXY-2,6-DIMETHYL C9H18O3 174.24 OC(C)(C)CC(CC(O)(C)C)=O 122-96-3 1,4-BIS-(HYDROXYETHYL)-PIPERAZIN C8H18N2O2 174.24 OCCN1CCN(CCO)CC1 20207-13-0 ETHANAMINE,2-[2-(4-MORPHOLINYL)ETHOXY]- C8H18N2O2 174.24 NCCOCCN1CCOCC1 112-48-1 1,2-DIBUTOXYETHAN C10H22O2 174.28 CCCCOCCOCCCC 107-74-4 HYDROXYCITRONELLOL C10H22O2 174.28 OCCC(C)CCCC(O)(C)C 1559-35-9 ETHYLENGLYKOL-MONO-(2-ETHYLHEXYL)-ETHER C10H22O2 174.28 OCCOCC(CC)CCCC 112-47-0 1,10-DECANDIOL C10H22O2 174.28 OCCCCCCCCCCO 18388-45-9 silane,diethoxymethyl-2-propenyl- C8H18O2Si 174.31 CCO[Si](C)(OCC)CC=C 544-02-5 DIISOPENTYLSULFID C10H22S 174.35 CC(C)CCSCCC(C)C 3698-94-0 1-(ETHYLTHIO)OCTAN C10H22S 174.35 CCCCCCCCSCC 143-10-2 1-DECANTHIOL C10H22S 174.35 CCCCCCCCCCS 598-14-1 ETHYLARSONDICHLORID C2H5AsCl2 174.89 CC[As](Cl)Cl 618-46-2 3-CHLORBENZOYLCHLORID C7H4Cl2O 175.01 ClC(=O)c(ccc1)cc1Cl 87-51-4 indoleaceticacid C10H9NO2 175.18 OC(=O)Cc1c[nH]c2c1cccc2 14091-93-1 2-buten-1-one,3-(methylamino)-1-phenyl- C11H13NO 175.23 CNC(C)=CC(c1ccccc1)=O 708-43-0 1-butylbenzotriazole C10H13N3 175.23 CCCCn2c1ccccc1nn2 3603-45-0 ETHANOL,2-[2-(4-MORPHOLINYL)ETHOXY]- C8H17NO3 175.23 OCCOCCN1CCOCC1 4430-42-6 1-isothiocyanato-5-methylsulfanylpentane C7H13NS2 175.32 CSCCCCCN=C=S 107-37-9 TRICHLOR-2-PROPENYLSILAN C3H5Cl3Si 175.52 Cl[Si](Cl)(Cl)CC=C 50-81-7 ASCORBINSAEURE C6H8O6 176.12 OCC(O)C1OC(=O)C(O)=C1O 4164-37-8 1,4-DINITROPIPERAZIN C4H8N4O4 176.13O=N(=O)N1CCN(CC1)N(=O)=O 5972-09-8 3-(METHYLAMINO)PHTHALIMID C9H8N2O2 176.17 CNc1cccc2c1C(=O)NC2=O 6639-86-7 2-methylquinoxaline-1,4-dioxide C9H8N2O2 176.17 Cc2cn(=O)c1ccccc1n2=O 112-15-2 2-(2-ETHOXYETHOXY)ETHANOLACETAT C8H16O4 176.21 CCOCCOCCOC(C)=O 294-93-9 1,4,7,10-TETRAOXACYCLODODECAN C8H16O4 176.21 C1OCCOCCOCCOC1 13140-86-8 3-phenyl-1-cyclopropylurea C10H12N2O 176.22 O=C(NC1CC1)Nc2ccccc2 2182-66-3 silanediol,dimethyl-,diacetate C6H12O4Si 176.24 C[Si](C)(OC(C)=O)OC(C)=O 1496-94-2 tripropylphosphate C9H21OP 176.24 CCCP(CCC)(CCC)=O 18912-81-7 PENTYLDIGLYKOL C9H20O3 176.25 OCCOCCOCCCCC 29911-27-1 1,2-DIPROPYLENGLYKOLPROPYLETHER C9H20O3 176.25 CCCOCC(C)OCC(O)C 7775-00-0 3-(4-propan-2-ylphenyl)propanal C12H16O 176.26 CC(C)c(cc1)ccc1CCC=O 5349-62-2 4-methyl-1-phenylpentan-2-one C12H16O 176.26 CC(C)CC(=O)Cc1ccccc1 28217-92-7 2-(cyclohexylmethyl)pyrazine C11H16N2 176.26 C(CC1)CCC1Cc2cnccn2 16587-32-9 BENZO[B]THIOPHENE,2-PROPYL C11H12S 176.28 CCCc2sc1ccccc1c2 1078-71-3 HEPTYLBENZOL C13H20 176.30 CCCCCCCc1ccccc1 593-71-5 CHLORJODMETHAN CH2ClI 176.38 ClCI 1779-25-5 CHLORBIS(2-METHYLPROPYL)ALUMINIUM C8H18AlCl 176.66 CC(C)C[Al](Cl)CC(C)C 697-91-6 2,6-DICHLORCHINON C6H2Cl2O2 176.99 ClC1=CC(=O)C=C(Cl)C1=O

Page 88 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 1631-84-1 DICHLORPHENYLSILAN C6H6Cl2Si 177.10 Cl[SiH](Cl)c1ccccc1 1660-15-7 3,6-DIAMINOPHTHALAMID C8H7N3O2 177.16 Nc2c1C(=O)NC(c1c(N)cc2)=O 102-01-2 3-OXO-N-PHENYLBUTANAMIDE C10H11NO2 177.20 CC(=O)CC(=O)Nc1ccccc1 1563-87-7 N-ACETYL-N-PHENYLACETAMID C10H11NO2 177.20 CC(=O)N(c1ccccc1)C(C)=O 3376-24-7 2-METHYL-N-(PHENYLMETHYLEN)-2-PROPANAMIN-N-OXIDC11H15NO 177.24 CC(C)(C)N(=O)=Cc1ccccc1 18171-59-0 DIMETHYLDICHLOROMETHYLCHLOROSILANE C3H7Cl3Si 177.53 ClC(Cl)[Si](C)(C)Cl 141-57-1 TRICHLORPROPYLSILAN C3H7Cl3Si 177.53 CCC[Si](Cl)(Cl)Cl 2466-09-3 PYROPHOSPHORSAEURE H4O7P2 177.98 OP(O)(OP(O)(O)=O)=O 5057-96-5 D-WEINSAEUREDIMETHYLESTER C6H10O6 178.14 COC(C(O)C(O)C(OC)=O)=O 608-69-5 (2R,3R)-REL-2,3-DIHYDROXYBUTANDISAEUREDIMETHYLESTERC6H10O6 178.14 COC(C(O)C(O)C(OC)=O)=O 90-80-2 3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-one C6H10O6 178.14 OCC1OC(C(O)C(O)C1O)=O 4437-22-3 2-(furan-2-ylmethoxymethyl)furan C10H10O3 178.19 O(Cc2occc2)Cc1occc1 111-17-1 3-(2-carboxyethylsulfanyl)propanoic acid C6H10O4S 178.21 OC(CCSCCC(O)=O)=O 136-60-7 BENZOESAEUREBUTYLESTER C11H14O2 178.23 CCCCOC(=O)c1ccccc1 94-86-0 2-ethoxy-5-[(e)-prop-1-enyl]phenol C11H14O2 178.23 CCOc1ccc(C=CC)cc1O 3854-90-8 3,5-DIETHYLBENZOESAEURE C11H14O2 178.23 CCc1cc(C(O)=O)cc(CC)c1 20651-71-2 4-BUTYLBENZOESAEURE C11H14O2 178.23 CCCCc1ccc(C(O)=O)cc1 2529-39-7 2,3,4,5-TETRAMETHYLBENZOESAEURE C11H14O2 178.23 OC(=O)c(cc1C)c(C)c(C)c1C 98-73-7 4-(1,1-DIMETHYLETHYL)BENZOESAEURE C11H14O2 178.23 CC(C)(C)c1ccc(C(O)=O)cc1 3025-88-5 2,5-dimethylhexane-2,5-dihydroperoxide C8H18O4 178.23 OOC(C)(C)CCC(C)(C)OO 7498-54-6 3-(1,1-DIMETHYLETHYL)BENZOESAEURE C11H14O2 178.23 CC(C)(C)c1cc(C(O)=O)ccc1 2408-38-0 2,3,4,6-TETRAMETHYLBENZOESAEURE C11H14O2 178.23 OC(=O)c(c(C)cc1C)c(C)c1C 112-50-5 ETHYLTRIGLYKOL C8H18O4 178.23 OCCOCCOCCOCC 2604-45-7 2,3,5,6-TETRAMETHYLBENZOESAEURE C11H14O2 178.23 OC(=O)c(c1C)c(C)c(C)cc1C 112-49-2 2,5,8,11-TETRAOXADODECAN C8H18O4 178.23 COCCOCCOCCOC 104-20-1 4-(4-methoxyphenyl)butan-2-one C11H14O2 178.23 COc1ccc(CCC(C)=O)cc1 1077-58-3 2-(1,1-DIMETHYLETHYL)BENZOESAEURE C11H14O2 178.23 CC(C)(C)c1ccccc1C(O)=O 7160-01-2 N,N-DIMETHYL-N`-(4-METHYLPHENYL)-HARNSTOFF C10H14N2O 178.23 Cc1ccc(cc1)NC(=O)N(C)C 85-01-8 PHENANTHREN C14H10 178.23 c(ccc2c1ccccc1c3)cc2c3 120-12-7 ANTHRACEN C14H10 178.23 c(ccc1cc2ccccc2c3)cc31 501-65-5 DIPHENYLACETYLEN C14H10 178.23 c(cc1)ccc1C#Cc2ccccc2 3445-42-9 ALPHA,ALPHA-DIMETHYL-4-(1-METHYLETHYL)BENZOLMETHANOLC12H18O 178.27 CC(C)c1ccc(C(O)(C)C)cc1 10415-87-9 3-methyl-1-phenylpentan-3-ol C12H18O 178.27 CCC(O)(C)CCc1ccccc1 879-97-0 4-(1,1-DIMETHYLETHYL)-2,6-DIMETHYLPHENOL C12H18O 178.27 CC(C)(C)c(cc1C)cc(C)c1O 7779-78-4 4-methyl-1-phenylpentan-2-ol C12H18O 178.27 CC(C)CC(O)Cc1ccccc1 1660-04-4 1-ADAMANTYL-METHYLKETON C12H18O 178.27CC(C2(CC3C1)CC(C3)CC1C2)=O 3374-41-2 3,5-diisopropylphenol C12H18O 178.27 CC(C)c(c1)cc(C(C)C)cc1O 10604-70-3 hexanebis(thioic)acid C6H10O2S2 178.27 SC(CCCCC(S)=O)=O 107133-43-7 exo-hydroxy-endo-endo-tetracyclo[6.2.1.13,602,7]do C12H18O 178.27OC2CC4CC2C3C4C1CC3CC1 74007-11-7 exo-4-hydroxy-exo-exo-tetracyclo[6.2.1.13,602,7]do C12H18O 178.27OC2CC4CC2C3C4C1CC3CC1 598-04-9 DIBUTYLSULFON C8H18O2S 178.29 CCCCS(CCCC)(=O)=O 1886-75-5 2-((1,1-DIMETHYLETHYL)SULFONYL)-2-METHYLPROPAN C8H18O2S 178.29 CC(C)(C)S(C(C)(C)C)(=O)=O 2031-67-6 METHYLTRIETHOXYSILAN C7H18O3Si 178.30 CCO[Si](C)(OCC)OCC 707-35-7 1,3,5-TRIMETHYLTRICYCLO(3.3.1.1(3,7))DECAN C13H22 178.31CC1(C3)CC2(C)CC3(C)CC(C1)C2 2050-87-5 3-prop-2-enylsulfanyldisulfanylprop-1-ene C6H10S3 178.34 C=CCSSSCC=C 1191-62-4 1,8-OCTANDITHIOL C8H18S2 178.36 SCCCCCCCCS 110-06-5 DI-TERT.-BUTYLSULFID C8H18S2 178.36 CC(C)(C)SSC(C)(C)C 629-45-8 DIBUTYLDISULFID C8H18S2 178.36 CCCCSSCCCC 629-04-9 1-BROMHEPTAN C7H15Br 179.10 CCCCCCCBr 680-31-9 HEXAMETHYLPHOSPHORSAEURETRIAMID C6H18N3OP 179.20 CN(C)P(=O)(N(C)C)N(C)C 230-27-3 BENZO(H)CHINOLIN C13H9N 179.22 c(cnc2c1ccccc1c3)cc2c3 122-42-9 PHENYLCARBAMIDSAEURE-1-METHYLETHYLESTER C10H13NO2 179.22 CC(C)OC(=O)Nc1ccccc1 5532-90-1 PHENYLCARBAMIDSAEUREPROPYLESTER C10H13NO2 179.22 CCCOC(=O)Nc1ccccc1 62-44-2 PHENACETIN C10H13NO2 179.22 CCOc1ccc(cc1)NC(C)=O 260-94-6 ACRIDIN C13H9N 179.22 c(ccc1cc2ccccc2n3)cc31 229-87-8 PHENANTHRIDIN C13H9N 179.22 c(ccc2c1ccccc1c3)cc2n3 85-02-9 BENZO(F)CHINOLIN C13H9N 179.22 c(ccc2c1ccccc1c3)nc2c3 260-36-6 benzo[g]quinoline C13H9N 179.22 c(ccc2cc1ccccc1c3)nc32 7291-00-1 n,n-dimethyl4-methoxybenzamide C10H13NO2 179.22 COc1ccc(cc1)C(=O)N(C)C 5511-18-2 1-ADAMANTYLCARBOXAMID C11H17NO 179.26O=C(C32CC(CC1C3)CC(C1)C2)N 1679-64-7 TEREPHTHALSAEUREMONOMETHYLETHER C9H8O4 180.16 COC(=O)c(cc1)ccc1C(O)=O 50-78-2 2-(ACETYLOXY)BENZOESAEURE C9H8O4 180.16 CC(=O)Oc1ccccc1C(O)=O

Page 89 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 104-04-1 N-(4-NITROPHENYL)ACETAMID C8H8N2O3 180.16 CC(=O)Nc1ccc(cc1)N(=O)=O 83-67-0 THEOBROMIN C7H8N4O2 180.16 Cn1cnc(n2C)c1c(=O)[nH]c2=O 3615-56-3 d-sorbose C6H12O6 180.16 OCC(O)C(O)C(O)C(CO)=O 58-55-9 3,7-DIHYDRO-1,3-DIMETHYL-1H-PURIN-2,6-DION C7H8N4O2 180.16 Cn2c1nc[nH]c1c(=O)n(C)c2=O 59-23-4 D-GALACTOSE C6H12O6 180.16 OCC(O)C(O)C(O)C(O)C=O 3458-28-4 D-MANNOSE C6H12O6 180.16 OCC(O)C(O)C(O)C(O)C=O 50-99-7 D-GLUCOSE C6H12O6 180.16 OCC(OC1O)C(O)C(O)C1O 921-60-8 l-glucose C6H12O6 180.16 OCC(OC1O)C(O)C(O)C1O 87-89-8 MESO-INOSIT C6H12O6 180.16 OC1C(O)C(O)C(O)C(O)C1O 486-25-9 9-FLUORENON C13H8O 180.20 O=c3c1ccccc1c2ccccc32 774-40-3 mandelicacidethylester C10H12O3 180.20 CCOC(=O)C(O)c1ccccc1 150-69-6 (4-ethoxyphenyl)-urea C9H12N2O2 180.20 CCOc1ccc(cc1)NC(=O)N 230-46-6 1,7-phenanthroline C12H8N2 180.21 c(cnc2c1ccccc1c3)nc2c3 92-82-0 PHENAZIN C12H8N2 180.21 c(ccc1nc2ccccc2n3)cc31 230-07-9 4,7-phenanthroline C12H8N2 180.21 c(ccc2c1cccnc1c3)nc2c3 230-17-1 BENZO(C)CINNOLIN C12H8N2 180.21 c(ccc2c1ccccc1n3)cc2n3 66-71-7 1,10-PHENANTHROLIN C12H8N2 180.21 c(cnc2c1ncccc1c3)cc2c3 2525-41-9 (1-PROPINYLSULFONYL)BENZOL C9H8O2S 180.22 CC#CS(c1ccccc1)(=O)=O 2525-42-0 (1,2-PROPADIENYLSULFONYL)BENZOL C9H8O2S 180.22 C=C=CS(c1ccccc1)(=O)=O 2525-40-8 (2-PROPINYLSULFONYL)BENZOL C9H8O2S 180.22 C#CCS(c1ccccc1)(=O)=O 857237-25-3 1-PROPANOL,2-(1-PHENYLETHOXY)- C11H16O2 180.24 OCC(C)OC(C)c1ccccc1 871518-84-2 2-PROPANOL,1-(1-PHENYLETHOXY)- C11H16O2 180.24 OC(C)COC(C)c1ccccc1 103-30-0 TRANS-STILBEN C14H12 180.25 c(cc2)ccc2C=Cc1ccccc1 613-31-0 9,10-DIHYDROANTHRACEN C14H12 180.25 C3c1ccccc1Cc2ccccc32 645-49-8 CIS-STILBEN C14H12 180.25 c(cc2)ccc2C=Cc1ccccc1 2523-37-7 9-METHYL-9H-FLUOREN C14H12 180.25 CC3c1ccccc1c2ccccc32 776-35-2 9,10-DIHYDROPHENANTHREN C14H12 180.25 C3c1ccccc1c2ccccc2C3 705-62-4 n,n-dimethyl-n'-phenyl-thiourea C9H12N2S 180.27 CN(C)C(=S)Nc1ccccc1 90-42-6 2-CYCLOHEXYLCYCLOHEXANON C12H20O 180.29 O=C2CCCCC2C1CCCCC1 21662-13-5 (2e,6e)-dodeca-2,6-dienal C12H20O 180.29 CCCCCC=CCCC=CC=O 21662-16-8 (2e,4e)-dodeca-2,4-dienal C12H20O 180.29 CCCCCCCC=CC=CC=O 55704-78-4 2,5-dimethyl-1,4-dithiane-2,5-diol C6H12O2S2 180.29 OC1(C)CSC(O)(C)CS1 98-56-6 1-CHLOR-4-(TRIFLUORMETHYL)BENZOL C7H4ClF3 180.56 FC(F)(F)c(cc1)ccc1Cl 124-72-1 1-bromo-1,2,2,2-tetrafluoroethane C2HBrF4 180.93 FC(Br)C(F)(F)F 272-30-0 selanonaphthene C8H6Se 181.10 c(ccc1[Se]c2)cc1c2 18771-85-2 benzofurazan,4-nitro-,1-oxide C6H3N3O4 181.11 O=N(=O)c1cccc2c1non2=O 3651-23-8 DIALLYLDICHLORSILAN C6H10Cl2Si 181.14 Cl[Si](Cl)(CC=C)CC=C 60-18-4 L-TYROSIN C9H11NO3 181.19[NH3+]C(Cc(cc1)ccc1O)C([O-])=O 538-51-2 N-(PHENYLMETHYLEN)BENZOLAMIN C13H11N 181.23 c(cc2)ccc2N=Cc1ccccc1 1484-12-4 N-METHYLCARBAZOL C13H11N 181.23 Cn3c1ccccc1c2ccccc32 54564-31-7 2-NITROTRICYCLO(3.3.1.1(3,7))DECAN C10H15NO2 181.23O=N(C2C(CC3C1)CC1CC2C3)=O 7575-82-8 1-NITROTRICYCLO(3.3.1.1(3,7))DECAN C10H15NO2 181.23O=N(C1(CC3C2)CC2CC(C3)C1)=O 7784-34-1 ARSENTRICHLORID AsCl3 181.28 Cl[As](Cl)Cl 101-83-7 N-CYCLOHEXYLCYCLOHEXANAMIN C12H23N 181.32 C(CC1)CCC1NC2CCCCC2 120-82-1 1,2,4-TRICHLORBENZOL C6H3Cl3 181.45 Clc(ccc1Cl)cc1Cl 87-61-6 1,2,3-TRICHLORBENZOL C6H3Cl3 181.45 Clc1cccc(Cl)c1Cl 108-70-3 1,3,5-TRICHLORBENZOL C6H3Cl3 181.45 Clc1cc(Cl)cc(Cl)c1 76-02-8 TRICHLORACETYLCHLORID C2Cl4O 181.83 ClC(Cl)(Cl)C(Cl)=O 771-56-2 PENTAFLUORMETHYLBENZOL C7H3F5 182.09 Fc1c(F)c(F)c(C)c(F)c1F 618-85-9 1-METHYL-3,5-DINITROBENZOL C7H6N2O4 182.13Cc1cc(cc(c1)N(=O)=O)N(=O)=O 610-39-9 4-METHYL-1,2-DINITROBENZOL C7H6N2O4 182.13 Cc(ccc1N(=O)=O)cc1N(=O)=O 619-15-8 2-METHYL-1,4-DINITROBENZOL C7H6N2O4 182.13 Cc1cc(ccc1N(=O)=O)N(=O)=O 121-14-2 1-METHYL-2,4-DINITROBENZOL C7H6N2O4 182.13 Cc1ccc(cc1N(=O)=O)N(=O)=O 606-20-2 2-METHYL-1,3-DINITROBENZOL C7H6N2O4 182.13 Cc1c(cccc1N(=O)=O)N(=O)=O 611-38-1 (DINITROMETHYL)BENZOL C7H6N2O4 182.13 O=N(C(c1ccccc1)N(=O)=O)=O 78-40-0 PHOSPHORSAEURETRIETHYLESTER C6H15O4P 182.16 CCOP(OCC)(OCC)=O 93-07-2 3,4-DIMETHOXYBENZOESAEURE C9H10O4 182.17 COc1ccc(C(O)=O)cc1OC 1132-21-4 3,5-DIMETHOXYBENZOESAEURE C9H10O4 182.17 COc1cc(C(O)=O)cc(OC)c1 1466-76-8 2,6-DIMETHOXYBENZOESAEURE C9H10O4 182.17 COc1cccc(OC)c1C(O)=O 134-96-3 benzaldehyde, 4-hydroxy-3,5-dimethoxy- C9H10O4 182.17 COc1cc(C=O)cc(OC)c1O 1521-38-6 2,3-DIMETHOXYBENZOESAEURE C9H10O4 182.17 COc1cccc(C(O)=O)c1OC 2785-98-0 2,5-DIMETHOXYBENZOESAEURE C9H10O4 182.17 COc(ccc1OC)cc1C(O)=O

Page 90 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 91-52-1 2,4-DIMETHOXYBENZOESAEURE C9H10O4 182.17 COc(ccc1C(O)=O)cc1OC 608-66-2 GALACTITOL C6H14O6 182.17 OCC(O)C(O)C(O)C(O)CO 69-65-8 D-MANNITOL C6H14O6 182.17 OCC(O)C(O)C(O)C(O)CO 50-70-4 SORBIT C6H14O6 182.17 OCC(O)C(O)C(O)C(O)CO 330-39-2 N-(3-FLUORPHENYL)-N,N-DIMETHYLHARNSTOFF C9H11FN2O 182.20 Fc1cc(ccc1)NC(=O)N(C)C 332-33-2 N`-(4-FLUOROPHENYL)-N,N-DIMETHYLHARNSTOFF C9H11FN2O 182.20 Fc1ccc(cc1)NC(=O)N(C)C 229-95-8 6h-dibenzo[b,d]-pyran C13H10O 182.22 O3c2ccccc2c1ccccc1C3 13184-86-6 4-(ethoxymethyl)-2-methoxyphenol C10H14O3 182.22 CCOCc(ccc1O)cc1OC 14059-92-8 4-ethyl-2,6-dimethoxyphenol C10H14O3 182.22 CCc(cc1OC)cc(OC)c1O 119-61-9 DIPHENYLMETHANON C13H10O 182.22 O=C(c2ccccc2)c1ccccc1 707-07-3 ORTHOBENZOICACID,TRIMETHYLESTER C10H14O3 182.22 COC(OC)(OC)c1ccccc1 92-83-1 9H-XANTHEN C13H10O 182.22 O3c1ccccc1Cc2ccccc32 103-33-3 DIPHENYLDIAZEN C12H10N2 182.22 c(cc2)ccc2N=Nc1ccccc1 5535-52-4 1-(ETHENYLSULFONYL)-4-METHYL-BENZOL C9H10O2S 182.24 Cc1ccc(cc1)S(=O)(=O)C=C 103-29-7 BIBENZYL C14H14 182.26 C(Cc1ccccc1)c2ccccc2 612-00-0 1,1-DIPHENYLETHAN C14H14 182.26 CC(c2ccccc2)c1ccccc1 713-36-0 1-METHYL-2-(PHENYLMETHYL)BENZOL C14H14 182.26 Cc2ccccc2Cc1ccccc1 613-33-2 4,4`-DIMETHYLBIPHENYL C14H14 182.26 Cc1ccc(cc1)c(cc2)ccc2C 612-75-9 3,3`-DIMETHYLBIPHENYL C14H14 182.26 Cc1cc(ccc1)c(ccc2)cc2C 605-39-0 2,2`-BITOLUYL C14H14 182.26 Cc1ccccc1c2ccccc2C 830-13-7 CYCLODODECANON C12H22O 182.30 O=C1CCCCCCCCCCC1 72845-33-1 3-ethoxy-3,7-dimethylocta-1,6-diene C12H22O 182.30 CCOC(C)(CCC=C(C)C)C=C 18368-91-7 6-ethyl-1,5,5-trimethylbicyclo[2.2.1]heptan-6-ol C12H22O 182.30CCC2(O)C1(C)CC(CC1)C2(C)C 2437-56-1 1-TRIDECEN C13H26 182.35 CCCCCCCCCCCC=C 1795-20-6 1-CYCLOPENTYLOCTAN C13H26 182.35 CCCCCCCCC1CCCC1 5943-34-0 2-propan-2-ylsulfanyldisulfanylpropane C6H14S3 182.37 CC(C)SSSC(C)C 6028-61-1 1-propylsulfanyldisulfanylpropane C6H14S3 182.37 CCCSSSCCC 273-15-4 2,1,3-benzoselenadiazole C6H4N2Se 183.07 n1[se]nc2ccccc12 771-60-8 2,3,4,5,6-PENTAFLUORBENZOLAMIN C6H2F5N 183.08 Fc1c(F)c(F)c(N)c(F)c1F 618-87-1 3,5-DINITROBENZOLAMIN C6H5N3O4 183.12Nc1cc(cc(c1)N(=O)=O)N(=O)=O 30560-19-1 ACETYLHIOAMIDOPHOSPHORSAEURE-O,S-DIMETHYLESTERC4H10NO3PS 183.17 COP(SC)(=O)NC(C)=O 81-07-2 1,2-BENZISOTHIAZOL-3(2H)-ON-1,1-DIOXID C7H5NO3S 183.19 O=C(c1ccccc21)NS2(=O)=O 135-67-1 10H-PHENOXAZIN C12H9NO 183.21 O3c1ccccc1Nc2ccccc32 103-32-2 N-PHENYLBENZOLMETHANAMIN C13H13N 183.25 N(Cc1ccccc1)c2ccccc2 14062-80-7 n,n-dimethylp-chlorobenzamide C9H10ClNO 183.64 Clc1ccc(cc1)C(=O)N(C)C 1558-25-4 TRICHLOR(CHLORMETHYL)SILAN CH2Cl4Si 183.93 ClC[Si](Cl)(Cl)Cl 558-17-8 2-IOD-2-METHYLPROPAN C4H9I 184.02 CC(C)(C)I 542-69-8 1-BUTYLIODID C4H9I 184.02 CCCCI 677-71-4 1,1,1,3,3,3-hexafluoro-2,2-propanediol C3H2F6O2 184.04 FC(F)(F)C(O)(O)C(F)(F)F 771-61-9 PENTAFLUORPHENOL C6HF5O 184.06 Fc1c(F)c(F)c(O)c(F)c1F 329-71-5 2,5-DINITROPHENOL C6H4N2O5 184.11Oc1cc(ccc1N(=O)=O)N(=O)=O 573-56-8 2,6-DINITROPHENOL C6H4N2O5 184.11Oc1c(cccc1N(=O)=O)N(=O)=O 51-28-5 2,4-DINITROPHENOL C6H4N2O5 184.11Oc1ccc(cc1N(=O)=O)N(=O)=O 66-56-8 2,3-DINITROPHENOL C6H4N2O5 184.11Oc1cccc(c1N(=O)=O)N(=O)=O 586-11-8 3,5-DINITROPHENOL C6H4N2O5 184.11Oc1cc(cc(c1)N(=O)=O)N(=O)=O 577-71-9 3,4-DINITROPHENOL C6H4N2O5 184.11Oc(ccc1N(=O)=O)cc1N(=O)=O 99-24-1 GALLICACIDMETHYLESTER C8H8O5 184.15 COC(=O)c(cc1O)cc(O)c1O 57-44-3 5,5-DIETHYL-2,4,6(1H,3H,5H)-PYRIMIDINTRION C8H12N2O3 184.19CCC1(CC)C(=O)NC(=O)NC1=O 262-12-4 DIBENZO(B,E)(1,4)DIOXIN C12H8O2 184.19 O3c1ccccc1Oc2ccccc32 946-80-5 (PHENOXYMETHYL)BENZOL C13H12O 184.23 O(Cc1ccccc1)c2ccccc2 3597-91-9 1,1-BIPHENYL-4-METHANOL C13H12O 184.23 OCc2ccc(cc2)c1ccccc1 28994-41-4 2-(PHENYLMETHYL)PHENOL C13H12O 184.23 Oc2ccccc2Cc1ccccc1 22272-48-6 3-benzylphenol C13H12O 184.23 Oc2cc(Cc1ccccc1)ccc2 101-53-1 4-(PHENYLMETHYL)PHENOL C13H12O 184.23 Oc2ccc(Cc1ccccc1)cc2 1134-35-6 4,4-DIMETHYL-2,2-BIPYRIDIN C12H12N2 184.24 Cc1cc(ncc1)c(ncc2)cc2C 122-66-7 1,2-DIPHENYLHYDRAZIN C12H12N2 184.24 c(cc1)ccc1NNc2ccccc2 101-54-2 N-PHENYL-1,4-BENZOLDIAMIN C12H12N2 184.24 Nc2ccc(Nc1ccccc1)cc2 92-87-5 4,4`-DIAMINOBIPHENYL C12H12N2 184.24 Nc2ccc(cc2)c(cc1)ccc1N 233-02-3 naphtho[2,1,b]thiophene C12H8S 184.26 c(ccc1c2cc3)cc1ccc2s3 268-77-9 naphtho[2,3,b]thiophene C12H8S 184.26 c(ccc1cc2sc3)cc1cc2c3 234-41-3 naphtho[1,2,b]thiophene C12H8S 184.26 c(ccc1c2sc3)cc1ccc2c3 132-65-0 DIBENZOTHIOPHEN C12H8S 184.26 c(ccc1c2ccccc2s3)cc31

Page 91 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 112-38-9 UNDECYLENSAEURE C11H20O2 184.28 OC(CCCCCCCCC=C)=O 103-11-7 2-ETHYLHEXYLACRYLAT C11H20O2 184.28 CCCCC(CC)COC(=O)C=C 7493-59-6 undecane-2,3-dione C11H20O2 184.28 CCCCCCCCC(=O)C(C)=O 104-67-6 5-HEPTYLDIHYDRO-2(3H)-FURANON C11H20O2 184.28 CCCCCCCC1OC(CC1)=O 7011-83-8 5-hexyl-5-methyloxolan-2-one C11H20O2 184.28 CCCCCCC1(C)OC(CC1)=O 2717-39-7 1,4,5,8-TETRAMETHYLNAPHTHALIN C14H16 184.28 Cc1ccc(C)c2c1c(C)ccc2C 1634-09-9 1-BUTYLNAPHTHALIN C14H16 184.28 CCCCc2c1ccccc1ccc2 59919-41-4 NAPHTHALENE,2,6-DIETHYL- C14H16 184.28 CCc(ccc1cc2CC)cc1cc2 934-36-1 1,3-benzodithiole-2-thione C7H4S3 184.30 S=C2Sc1ccccc1S2 3354-42-5 3h-1,2-benzodithiole-3-thione C7H4S3 184.30S=C1[CH+]C=CC=C1C(=S)[S-] 123-18-2 2,4,8-TRIMETHYLNONAN-6-ON C12H24O 184.32 CC(C)CC(C)CC(CC(C)C)=O 112-54-9 DODECANAL C12H24O 184.32 CCCCCCCCCCCC=O 110-41-8 METHYLNONYLACETALDEHYD C12H24O 184.32 CCCCCCCCCC(C)C=O 765-05-9 1-(ethenyloxy)-decane C12H24O 184.32 CCCCCCCCCCOC=C 35660-96-9 2,2,4,4-TETRAMETHYL-3-TERT.-BUTYLPENTAN C13H28 184.36CC(C)(C)C(C(C)(C)C)C(C)(C)C 1560-97-0 2-METHYLDODECAN C13H28 184.36 CCCCCCCCCCC(C)C 629-50-5 TRIDECAN C13H28 184.36 CCCCCCCCCCCCC 26675-46-7 2-CHLOR-2-(DIFLUORMETHOXY)-1,1,1-TRIFLUORETHAN C3H2ClF5O 184.49 FC(F)OC(Cl)C(F)(F)F 20940-42-5 1-(m-chlorophenyl)-3-methylurea C8H9ClN2O 184.62 Clc1cc(ccc1)NC(=O)NC 14532-24-2 HEXYLSULFONYLCHLORID C6H13ClO2S 184.69 CCCCCCS(Cl)(=O)=O 1833-51-8 silane,(chloromethyl)dimethylphenyl- C9H13ClSi 184.74 ClC[Si](C)(C)c1ccccc1 618-32-6 BENZOYLBROMID C7H5BrO 185.02 BrC(=O)c1ccccc1 14417-01-7 N,N-DIMETHYLBENZENESULPHONAMIDE C8H11NO2S 185.24 CN(C)S(c1ccccc1)(=O)=O 124-22-1 1-DODECANAMIN C12H27N 185.35 NCCCCCCCCCCCC 102-82-9 N,N-DIBUTYL-1-BUTANAMIN C12H27N 185.35 CCCCN(CCCC)CCCC 122-04-3 4-nitrobenzoylchloride C7H4ClNO3 185.57 ClC(=O)c1ccc(cc1)N(=O)=O 2150-88-1 methyl-n-(3-chlorophenyl)carbamate C8H8ClNO2 185.61 COC(=O)Nc(ccc1)cc1Cl 540-49-8 1,2-DIBROMETHEN C2H2Br2 185.85 BrC=CBr 590-12-5 (E)-1,2-DIBROMETHEN C2H2Br2 185.85 BrC=CBr 359-65-9 BIS-(TRIFLUORMETHYL)-HYDROXYPHOSPHIN C2HF6OP 185.99 FC(F)(F)P(O)C(F)(F)F 6933-10-4 4-BROM-3-METHYLBENZOLAMIN C7H8BrN 186.05 Nc(ccc1Br)cc1C 392-56-3 HEXAFLUORBENZOL C6F6 186.06 Fc1c(F)c(F)c(F)c(F)c1F 713-68-8 3-PHENOXYPHENOL C12H10O2 186.21 Oc2cc(Oc1ccccc1)ccc2 116047-10-0 1-methyl-4-(1-methylpyridin-1-ium-4-yl)pyridin-1-ium C12H14N2 186.25C[n+2]2ccc(cc2)=C(C=C1)C=CN1C 624-01-1 5-oxodecanoic acid C10H18O3 186.25 CCCCCC(CCCC(O)=O)=O 143-13-5 ESSIGSAEURENONYLESTER C11H22O2 186.29 CCCCCCCCCOC(C)=O 6454-22-4 2-HEXYL-4,5-DIMETHYL-1,3-DIOXOLAN C11H22O2 186.29 CCCCCCC(OC1C)OC1C 110-42-9 DECANSAEUREMETHYLESTER C11H22O2 186.29 CCCCCCCCCC(OC)=O 112-37-8 UNDECANSAEURE C11H22O2 186.29 CCCCCCCCCCC(O)=O 5451-52-5 AMEISENSAEUREDECYLESTER C11H22O2 186.29 CCCCCCCCCCOC=O 1079-71-6 1,2,3,4,5,6,7,8-OCTAHYDROANTHRACEN C14H18 186.29 C(CCc1cc2CCCCc2c3)Cc31 38462-22-5 5-methyl-2-(2-sulfanylpropan-2-yl)cyclohexan-1-one C10H18OS 186.32 CC(CCC1C(C)(C)S)CC1=O 112-58-3 DIHEXYLETHER C12H26O 186.34 CCCCCCOCCCCCC 112-53-8 1-DODECANOL C12H26O 186.34 OCCCCCCCCCCCC 3913-02-8 1-OCTANOL,2-BUTYL C12H26O 186.34 CCCCCCC(CO)CCCC 10522-26-6 1-UNDECANOL,2-METHYL- C12H26O 186.34 CCCCCCCCCC(C)CO 2627-95-4 disiloxane,1,3-diethenyl-1,1,3,3-tetramethyl- C8H18OSi2 186.40 C[Si](C)(O[Si](C)(C)C=C)C=C 3429-76-3 TRIMETHYLOCTYLSILAN C11H26Si 186.41 CCCCCCCC[Si](C)(C)C 2212-67-1 molinate C9H17NOS 187.30 CCSC(=O)N1CCCCCC1 1112-03-4 DIFLUOR-TRICHLORMETHYL-PHOSPHIN CCl3F2P 187.34 FP(F)C(Cl)(Cl)Cl 354-58-5 1,1,1-TRICHLORTRIFLUORETHAN C2Cl3F3 187.38 FC(F)(F)C(Cl)(Cl)Cl 76-13-1 1,1,2-TRICHLORTRIFLUORETHAN C2Cl3F3 187.38 FC(F)(Cl)C(F)(Cl)Cl 16532-02-8 silane,(bromomethyl)chlorodimethyl- C3H8BrClSi 187.54 BrC[Si](C)(C)Cl 557-91-5 1,1-DIBROMETHAN C2H4Br2 187.86 CC(Br)Br 106-93-4 1,2-DIBROMETHAN C2H4Br2 187.86 BrCCBr 7101-31-7 DIMETHYLDISELENID C2H6Se2 188.00 C[Se][Se]C 102-36-3 1,2-DICHLOR-4-ISOCYANATOBENZOL C7H3Cl2NO 188.01 Clc1ccc(N=C=O)cc1Cl 76-19-7 OCTAFLUORPROPAN C3F8 188.02 FC(F)(F)C(F)(F)C(F)(F)F 92-70-6 3-hydroxy-2-naphthoicacid C11H8O3 188.18 OC(=O)c2cc1ccccc1cc2O 7275-43-6 2,2'-bipyridine,1,1'-dioxide C10H8N2O2 188.18 O=n2ccccc2c1ccccn1=O 123-99-9 NONANDISAEURE C9H16O4 188.22 OC(CCCCCCCC(O)=O)=O 711-82-0 2-(1-naphthalenyloxy)-etahnol C12H12O2 188.22 OCCOc2c1ccccc1ccc2

Page 92 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 13431-57-7 NEOPENTYLGLYKOLDIACETAT C9H16O4 188.22 CC(C)(COC(C)=O)COC(C)=O 60-80-0 ANTIPYRIN C11H12N2O 188.23 CC2=CC(=O)N(c1ccccc1)N2C 14156-10-6 DECANPEROXOSAEURE C10H20O3 188.27 CCCCCCCCCC(OO)=O 1540-80-3 1,8-CYCLOTETRADECADIIN C14H20 188.31 C1CCC#CCCCCCC#CCC1 2292-79-7 DECAHYDRO-3,5,1,7-(1,2,3,4)BUTANTETRAYLNAPHTHALIN C14H20 188.31C(C(CC52)CC4C1CC3CC54)C1C2C3 698-42-0 4,5,6,7-TETRAHYDRO-1,3-BENZODITHIOL-2-THION C7H8S3 188.34 S=C2SC(CCCC1)=C1S2 5332-52-5 1-UNDECANTHIOL C11H24S 188.37 CCCCCCCCCCCS 292-46-6 1,2,3,5,6-pentathiepane C2H4S5 188.38 S1CSSSCS1 2051-60-7 2-CHLORBIPHENYL C12H9Cl 188.65 Clc2ccccc2c1ccccc1 597-63-7 TETRAETHYLGERMANIUM C8H20Ge 188.89 CC[Ge](CC)(CC)CC 6996-92-5 phenyl-selensaeure C6H6O2Se 189.07 O[Se](=O)c1ccccc1 41814-78-2 tricyclazole C9H7N3S 189.24 Cc2cccc3c2n1cnnc1s3 776-75-0 1-benzoylpiperidine C12H15NO 189.25 O=C(c1ccccc1)N2CCCCC2 112-57-2 TETRAETHYLENPENTAMIN C8H23N5 189.30 NCCNCCNCCNCCN 759-94-4 EPTC C9H19NOS 189.32 CCCN(CCC)C(SCC)=O 4430-39-1 1-isothiocyanato-6-methylsulfanylhexane C8H15NS2 189.34 CSCCCCCCN=C=S 17882-91-6 methanamine,1-(trimethylsilyl)-n-[(trimethylsilyl)methyl]- C8H23NSi2 189.45 C[Si](C)(C)CNC[Si](C)(C)C 2240-25-7 4-amino-5-bromo-2-hydroxypyrimidine C4H4BrN3O 190.00 BrC1=CNC(=O)N=C1N 2008-58-4 2,6-dichlorobenzamide C7H5Cl2NO 190.03 Clc1cccc(Cl)c1C(=O)N 6145-31-9 PHOSPHONICACID,1,2-ETHANEDIYLBIS- C2H8O6P2 190.03 OP(O)OCCOP(O)O 455-24-3 .ALPHA.,.ALPHA.,.ALPHA.-TRIFLUOR-P-TOLYLSAEURE C8H5F3O2 190.12 FC(F)(F)c1ccc(C(O)=O)cc1 1186-73-8 METHANTRICARBONSAEURETRIMETHYLESTER C7H10O6 190.15COC(=O)C(C(OC)=O)C(OC)=O 492-94-4 2-coco-furylfuran C10H6O4 190.15 O=C(c2occc2)C(c1occc1)=O 4008-48-4 5-NITRO-8-CHINOLINOL C9H6N2O3 190.16 Oc2c1ncccc1c(cc2)N(=O)=O 398-23-2 4,4`-DIFLUORBIPHENYL C12H8F2 190.19 Fc1ccc(cc1)c(cc2)ccc2F 388-82-9 2,2`-DIFLUORBIPHENYL C12H8F2 190.19 Fc1ccccc1c2ccccc2F 6066-49-5 3-butyl-3h-2-benzofuran-1-one C12H14O2 190.24 CCCCC2c1ccccc1C(O2)=O 88917-22-0 DIPROPYLENGLYKOL-MONOMETHYLETHER-ACETAT C9H18O4 190.24 COC(C)COC(C)COC(C)=O 116-06-3 2-METHYL-2-(METHYLTHIO)PROPANAL-O-((METHYLAMINO)CARBONYL)OXIMC7H14N2O2S 190.26 CSC(C)(C)C=NOC(=O)NC 3208-40-0 2-(3-phenylpropyl)oxolane C13H18O 190.28 C(CCC1CCCc2ccccc2)O1 32739-31-2 (2-(1,1-dimethylethoxy)methylethoxy)-2-propanol C10H22O3 190.28 OC(C)COCC(C)OC(C)(C)C 112-59-4 2-(2-(HEXYLOXY)ETHOXY)ETHANOL C10H22O3 190.28 OCCOCCOCCCCCC 132739-31-2 DIPROPYLENGLYKOL-MONO-TERT.-BUTYLETHER C10H22O3 190.28 OC(C)COCC(C)OC(C)(C)C 29911-28-2 1-BUTOXY-2-(2-HYDROXYPROPOXY)-PROPAN C10H22O3 190.28 CCCCOCC(C)OCC(O)C 58797-58-3 PROPAN-2-OL,1-[2-(TERT-BUTOXY)-ISOPROPOXY] C10H22O3 190.28 OC(C)COC(C)COC(C)(C)C 78-08-0 ETHENYLTRIETHOXYSILAN C8H18O3Si 190.31 CCO[Si](OCC)(OCC)C=C 17890-53-8 BENZO[B]THIOPHENE,2-BUTYL C12H14S 190.31 CCCCc2sc1ccccc1c2 1012-72-2 1,4-DI-TERT.-BUTYLBENZOL C14H22 190.33 CC(C)(C)c1ccc(C(C)(C)C)cc1 2189-60-8 OCTYLBENZOL C14H22 190.33 CCCCCCCCc1ccccc1 38842-05-6 1,2,3,5-TETRAETHYLBENZOL C14H22 190.33 CCc(cc1CC)cc(CC)c1CC 2164-87-6 HEXAHYDRO-1,3-BENZODITHIOLE-2-THION C7H10S3 190.35 S=C2SC1CCCCC1S2 51-20-7 5-BROM-2,4(1H,3H)-PYRIMIDINDION C4H3BrN2O2 190.98 Brc1c[nH]c(=O)[nH]c1=O 98-46-4 3-NITROBENZOTRIFLUORID C7H4F3NO2 191.11 FC(F)(F)c1cc(ccc1)N(=O)=O 149-74-6 DICHLORMETHYLPHENYLSILAN C7H8Cl2Si 191.13 C[Si](Cl)(Cl)c1ccccc1 10605-21-7 1H-BENZIMIDAZOL-2-YLCARBAMIDSAEUREMETHYLESTERC9H9N3O2 191.19 COC(=O)Nc2[nH]c1ccccc1n2 65-82-7 2-acetamido-4-methylsulfanylbutanoic acid C7H13NO3S 191.25 CSCCC(C(O)=O)NC(C)=O 515-84-4 TRICHLORESSIGSAEUREETHYLESTER C4H5Cl3O2 191.44 CCOC(C(Cl)(Cl)Cl)=O 106-39-8 4-BROMCHLORBENZOL C6H4BrCl 191.45 Clc1ccc(Br)cc1 18169-57-8 silane,trichloro(2-methylpropyl)- C4H9Cl3Si 191.56 CC(C)C[Si](Cl)(Cl)Cl 7521-80-4 TRICHLOROBUTYLSILAN C4H9Cl3Si 191.56 CCCC[Si](Cl)(Cl)Cl 99-54-7 3,4-DICHLORNITROBENZOL C6H3Cl2NO2 192.00 Clc1ccc(cc1Cl)N(=O)=O 1702-17-6 3,6-dichloropyridine-2-carboxylic acid C6H3Cl2NO2 192.00 OC(=O)c1nc(Cl)ccc1Cl 77-92-9 2-HYDROXY-1,2,3-PROPANTRICARBONSAEURE C6H8O7 192.12OC(CC(O)=O)(CC(O)=O)C(O)=O 552-30-7 1,3-DIHYDRO-1,3-DIOXO-5-ISOBENZOFURANCARBONSAEUREC9H4O5 192.13OC(=O)c(ccc1C2=O)cc1C(O2)=O 1205-17-0 3-(1,3-benzodioxol-5-yl)-2-methylpropanal C11H12O3 192.21 CC(C=O)Cc2cc1OCOc1cc2 55418-52-5 4-(1,3-benzodioxol-5-yl)butan-2-one C11H12O3 192.21 CC(CCc2cc1OCOc1cc2)=O 713-05-3 n-methyloxo-3-pyridinebutanamide C10H12N2O2 192.22 CNC(CCC(=O)c1cccnc1)=O 1638-16-0 1,1'-(1-methyl-1,2-ethanediyl)bis(oxy)bis2-propanol C9H20O4 192.25 OC(C)COCC(C)OCC(O)C 23305-64-8 ETHANOL,2-[2-(PROPOXYETHOXY)ETHOXY]- C9H20O4 192.25 OCCOCCOCCOCCC 776-88-5 5,5-DIMETHYL-2-PHENYL-1,3-DIOXAN C12H16O2 192.26 CC2(C)COC(OC2)c1ccccc1 2243-32-5 PENTAMETHYLBENZOESAEURE C12H16O2 192.26OC(=O)c(c(C)c1C)c(C)c(C)c1C 36627-56-2 N`-(3,5-DIMETHYLPHENYL)-N,N-DIMETHYLHARNSTOFF C11H16N2O 192.26 Cc1cc(cc(C)c1)NC(=O)N(C)C

Page 93 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 1961-96-2 INDENE,1-PHENYL- C15H12 192.26 c(cc2)ccc2C1C=Cc3c1cccc3 779-02-2 9-METHYLANTHRACEN C15H12 192.26 Cc3c1ccccc1cc2ccccc32 832-64-4 4-METHYLPHENANTHREN C15H12 192.26 Cc2cccc3c2c1ccccc1cc3 56011-02-0 2-(3-methylbutoxy)ethylbenzene C13H20O 192.30 CC(C)CCOCCc1ccccc1 22292-76-8 2-methyl-3,5-diisopropylphenol C13H20O 192.30 CC(C)c(cc1O)cc(C(C)C)c1C 15269-17-7 4-methyl-3,5-diisopropylphenol C13H20O 192.30 CC(C)c1cc(O)cc(C(C)C)c1C 20483-36-7 4-(2,6,6-trimethyl-1-cyclohexa-1,3-dienyl)butan-2-one C13H20O 192.30CC(=O)CCC1=C(C)C=CCC1(C)C 43052-87-5 (e)-1-(2,6,6-trimethyl-1-cyclohex-2-enyl)but-2-en-1-one C13H20O 192.30CC1(C)CCC=C(C)C1C(=O)C=CC 15269-16-6 4-methyl-2,5-diisopropylphenol C13H20O 192.30 CC(C)c1cc(C)c(C(C)C)cc1O 57378-68-4 (e)-1-(2,6,6-trimethyl-1-cyclohex-3-enyl)but-2-en-1-one C13H20O 192.30CC1(C)CC=CC(C)C1C(=O)C=CC 127-41-3 (3E)-4-(2,6,6-TRIMETHYL-2-CYCLOHEXEN-1-YL)-3-BUTEN-2-ONC13H20O 192.30CC1(C)CCC=C(C)C1C=CC(C)=O 14901-07-6 BETA-IONON C13H20O 192.30CC1(C)CCCC(C)=C1C=CC(C)=O 141-10-6 6,10-DIMETHYL-3,5,9-UNDECATRIEN-2-ON C13H20O 192.30CC(C)=CCCC(C)=CC=CC(C)=O 3867-15-0 1-(1-PIPERIDINYL)CYCLOHEXANCARBONITRIL C12H20N2 192.30 N#CC2(CCCCC2)N1CCCCC1 78-07-9 TRIETHOXYETHYLSILAN C8H20O3Si 192.33 CCO[Si](CC)(OCC)OCC 1687-36-1 1,3,5,7-TETRAMETHYLTRICYCLO(3.3.1.1(3,7))DECAN C14H24 192.34CC1(C2)CC(C)(CC2(C)C3)CC3(C)C1 28071-99-0 (4AALPHA,8AALPHA,9ABETA,10ABETA)-TETRADECAHYDROANTHRACENC14H24 192.34C(CCC1CC2CCCCC2C3)CC31 3489-28-9 1,9-NONANDITHIOL C9H20S2 192.39 SCCCCCCCCCS 98-66-8 4-CHLORBENZOLSULFONSAEURE C6H5ClO3S 192.62 Clc1ccc(cc1)S(O)(=O)=O 7783-79-1 (OC-6-11)-SELENFLUORID(SEF6) F6Se 192.95 F[Se](F)(F)(F)(F)F 773-82-0 PENTAFLUORBENZONITRIL C7F5N 193.07 Fc1c(F)c(F)c(C#N)c(F)c1F 111-83-1 1-OCTYLBROMID C8H17Br 193.13 CCCCCCCCBr 2571-54-2 2,4,6-TRIMETHOXYBENZONITRIL C10H11NO3 193.20 COc(cc1OC)cc(OC)c1C#N 1538-74-5 n-butyl-n-phenylcarbamate C11H15NO2 193.24 CCCCOC(=O)Nc1ccccc1 256-96-2 5-azadibenzo(a,e)cycloheptatriene C14H11N 193.25 c(ccc1[nH]c2ccccc2c3)cc1c3 613-13-8 2-ANTHRACENAMIN C14H11N 193.25 Nc(ccc2c3)cc2cc1ccccc31 18775-06-9 N,N-DIETHYLBENZOLCARBOTHIOAMID C11H15NS 193.31 CCN(CC)C(c1ccccc1)=S 993-10-2 TRICHLORMETHYLGERMAN CH3Cl3Ge 194.04 C[Ge](Cl)(Cl)Cl 120-61-6 TEREPHTHALSAEUREDIMETHYLESTER C10H10O4 194.18 COC(=O)c1ccc(C(OC)=O)cc1 1459-93-4 1,3-BENZOLDICARBONSAEUREDIMETHYLESTER C10H10O4 194.18 COC(=O)c1cc(C(OC)=O)ccc1 131-11-3 1,2-BENZOLDICARBONSAEUREDIMETHYLESTER C10H10O4 194.18 COC(=O)c1ccccc1C(OC)=O 7291-01-2 benzamide,n,n-dimethyl-4-nitro- C9H10N2O3 194.19CN(C)C(c(cc1)ccc1N(=O)=O)=O 58-08-2 COFFEIN C8H10N4O2 194.19Cn1cnc2c1c(=O)n(C)c(=O)n2C 6343-21-1 BICYCLO(2.2.1)HEPT-5-EN-2,2,3,3-TETRACARBONITRIL C11H6N4 194.19N#CC2(C#N)C1C=CC(C1)C2(C#N)C#N 6627-88-9 2,6-dimethoxy-4-prop-2-enylphenol C11H14O3 194.23 COc1cc(CC=C)cc(OC)c1O 90-44-8 9(10H)-ANTHRACENON C14H10O 194.23 O=C3c1ccccc1Cc2ccccc32 122-48-5 4-(4-hydroxy-3-methoxyphenyl)butan-2-one C11H14O3 194.23 COc1cc(CCC(C)=O)ccc1O 28170-54-9 N-(3-METHOXYPHENYL)-N,N-DIMETHYLHARNSTOFF C10H14N2O2 194.23 COc1cc(ccc1)NC(=O)N(C)C 7160-02-3 N`-(4-METHOXYPHENYL)-N,N-DIMETHYLHARNSTOFF C10H14N2O2 194.23 COc1ccc(cc1)NC(=O)N(C)C 112-60-7 TETRAETHYLENGLYKOL C8H18O5 194.23 OCCOCCOCCOCCO 13678-67-6 2-(furan-2-ylmethylsulfanylmethyl)furan C10H10O2S 194.25 S(Cc2occc2)Cc1occc1 14027-53-3 1-METHYL-4-(1-PROPINYLSULFONYL)BENZOL C10H10O2S 194.25 Cc1ccc(cc1)S(=O)(=O)C#CC 16192-08-8 1-METHYL-4-(1,2-PROPADIENYLSULFONYL)BENZOL C10H10O2S 194.25 Cc1ccc(cc1)S(=O)(=O)C=C=C 16192-07-7 1-METHYL-4-(2-PROPINYLSULFONYL)BENZOL C10H10O2S 194.25 Cc1ccc(cc1)S(CC#C)(=O)=O 98-49-7 HYDROPEROXIDE,1-METHYL-1-(4-(1-METHYLETHYL)PHENYL)ETHYLC12H18O2 194.27 OOC(C)(C)c(cc1)ccc1C(C)C 711-01-3 TRICYCLO(3.3.1.1(3,7))DECAN-1-CARBONSAEUREMETHYLESTERC12H18O2 194.27COC(C2(C3)CC(CC3C1)CC1C2)=O 26762-93-6 HYDROPEROXIDE,BIS(1-METHYLETHYL)PHENYL C12H18O2 194.27 OOc1cc(C(C)C)cc(C(C)C)c1 779-51-1 1,1'-(1-methyl-1,2-ethylidene)bisbenzene C15H14 194.27 CC(=Cc2ccccc2)c1ccccc1 704-38-1 di-thiophen-2-yl-methanone C9H6OS2 194.28 O=C(c2sccc2)c1sccc1 57069-86-0 4-(2,6,6-trimethyl-1-cyclohexa-1,3-dienyl)butan-2-ol C13H22O 194.31OC(C)CCC1=C(C)C=CCC1(C)C 25312-34-9 (e)-4-(2,6,6-trimethyl-1-cyclohex-2-enyl)but-3-en-2-ol C13H22O 194.31OC(C)C=CC1C(C)=CCCC1(C)C 22029-76-1 4-(2,6,6-trimethyl-1-cyclohexenyl)but-3-en-2-ol C13H22O 194.31OC(C)C=CC1=C(C)CCCC1(C)C 17283-81-7 4-(2,6,6-TRIMETHYLCYCLOHEXEN-1-YL)-BUTAN-2-ON C13H22O 194.31CC1(C)CCCC(C)=C1CCC(C)=O 31499-72-6 4-(2,6,6-trimethyl-1-cyclohex-2-enyl)butan-2-one C13H22O 194.31CC1(C)CCC=C(C)C1CCC(C)=O 3796-70-1 (5E)-6,10-DIMETHYL-5,9-UNDECADIEN-2-ON C13H22O 194.31CC(CCC=C(C)CCC=C(C)C)=O 36431-72-8 2,6,6,10-tetramethyl-1-oxaspiro[4.5]dec-9-ene C13H22O 194.31CC(CC1)OC21C(C)=CCCC2(C)C 99-77-4 4-NITROBENZOESAEUREETHYLESTER C9H9NO4 195.17CCOC(=O)c1ccc(cc1)N(=O)=O 578-95-0 9(10H)-ACRIDINON C13H9NO 195.22 O=C3c1ccccc1Nc2ccccc32 86-28-2 9-ETHYL-9H-CARBAZOL C14H13N 195.26 CCn3c1ccccc1c2ccccc32 3732-82-9 hexamethylthiophosphoramide C6H18N3PS 195.27 CN(C)P(=S)(N(C)C)N(C)C 98-07-7 BENZOTRICHLORID C7H5Cl3 195.47 ClC(Cl)(Cl)c1ccccc1 2314-97-8 TRIFLUORIODMETHAN CF3I 195.91 FC(F)(F)I

Page 94 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 509-14-8 TETRANITROMETHAN CN4O8 196.03O=N(=O)C(N(=O)=O)(N(=O)=O)N(=O)=O 373-80-8 PENTAFLUOR-(TRIFLUORMETHYL)-SCHWEFEL CF8S 196.06 FC(F)(F)S(F)(F)(F)(F)F 1464-42-2 selenomethionine C5H11NO2Se 196.11 C[Se]CCC([NH3+])C([O-])=O 2807-54-7 FURMARSAUREDIALLYLESTER C10H12O4 196.20C=CCOC(=O)C=CC(OCC=C)=O 999-21-3 diallylmaleate C10H12O4 196.20C=CCOC(=O)C=CC(OCC=C)=O 90-47-1 9H-XANTHEN-9-ON C13H8O2 196.20 O=C3c1ccccc1Oc2ccccc32 1421-63-2 1-(2,4,5-trihydroxyphenyl)butan-1-one C10H12O4 196.20 CCCC(=O)c(cc1O)c(O)cc1O 304-81-4 PHENAZIN-5-OXID C12H8N2O 196.21 O=n3c1ccccc1nc2ccccc32 13358-02-6 3-methyl-4-cyclohexene-1,1,2,2-tetracarbonitrile C11H8N4 196.21CC(C1(C#N)C#N)C=CCC1(C#N)C#N 6766-82-1 2,6-dimethoxy-4-propylphenol C11H16O3 196.24 CCCc(cc1OC)cc(OC)c1O 451-40-1 1,2-DIPHENYLETHANON C14H12O 196.25 O=C(Cc2ccccc2)c1ccccc1 92-91-1 1-1,1'-biphenyl-4-yl-ethanone C14H12O 196.25 CC(=O)c2ccc(cc2)c1ccccc1 67605-02-1 1-METHYL-4-[(1-METHYLETHENYL)SULFONYL)]-BENZOL C10H12O2S 196.27 Cc1ccc(cc1)S(=O)(=O)C(C)=C 32228-15-2 (E)-1-METHYL-4-(1-PROPENYLSULFONYL)-BENZOL C10H12O2S 196.27 Cc1ccc(cc1)S(=O)(=O)C=CC 3112-87-6 1-METHYL-4-(2-PROPENYLSULFONYL)BENZOL C10H12O2S 196.27 Cc1ccc(cc1)S(CC=C)(=O)=O 778-22-3 2,2-DIPHENYLPROPAN C15H16 196.29 CC(C)(c2ccccc2)c1ccccc1 4433-36-7 6,10-dimethylundec-9-en-2-one C13H24O 196.33 CC(CCCC(C)=O)CCC=C(C)C 3293-47-8 4-(2,6,6-trimethyl-1-cyclohexenyl)butan-2-ol C13H24O 196.33OC(C)CCC1=C(C)CCCC1(C)C 4420-74-0 1-PROPANETHIOL,3-(TRIMETHOXYSILYL) C6H16O3SSi 196.34 SCCC[Si](CO)(CO)CO 1120-36-1 1-TETRADECEN C14H28 196.37 CCCCCCCCCCCCC=C 2882-98-6 NONYLCYCLOPENTAN C14H28 196.37 CCCCCCCCCC1CCCC1 295-17-0 CYCLOTETRADECAN C14H28 196.37 C1CCCCCCCCCCCCC1 634-67-3 2,3,4-TRICHLORBENZOLAMIN C6H4Cl3N 196.46 Nc1ccc(Cl)c(Cl)c1Cl 6228-62-2 2,2'-selenobisaceticacid C4H6O4Se 197.05 OC(C[Se]CC(O)=O)=O 777-59-3 1-methyl-1-nitroso-3-(p-fluorophenyl)urea C8H8FN3O2 197.17 Fc1ccc(cc1)NC(=O)N(C)N=O 709-72-8 3-(nitrophenyl)-thiourea C7H7N3O2S 197.22 O=N(=O)c1cc(ccc1)NC(N)=S 779-84-0 N-(2-HYDROXYBENZYLIDEN)-ANILIN C13H11NO 197.23 Oc2ccccc2C=Nc1ccccc1 93-98-1 N-PHENYLBENZOESAEUREAMID C13H11NO 197.23 O=C(c1ccccc1)Nc2ccccc2 1137-96-8 N-(PHENYLMETHYLEN)BENZOLAMIN-N-OXID C13H11NO 197.23 O=N(c2ccccc2)=Cc1ccccc1 136-35-6 1,3-DIPHENYLTRIAZIN C12H11N3 197.24 c(cc2)ccc2N=NNc1ccccc1 673-04-1 2-METHOXY-4,6-BIS-(ETHYLAMINO)-1,3,5-TRIAZIN C8H15N5O 197.24 CCNc(n1)nc(NCC)nc1OC 60-09-3 4-(PHENYLAZO)BENZOLAMIN C12H11N3 197.24 Nc2ccc(N=Nc1ccccc1)cc2 2110-18-1 2-(3-phenylpropyl)pyridine C14H15N 197.28 C(Cc2ccccn2)Cc1ccccc1 151-67-7 BROMCHLOR-1,1,1-TRIFLUORETHAN C2HBrClF3 197.38 ClC(Br)C(F)(F)F 15950-66-0 2,3,4-TRICHLORPHENOL C6H3Cl3O 197.45 Oc1ccc(Cl)c(Cl)c1Cl 88-06-2 2,4,6-TRICHLORPHENOL C6H3Cl3O 197.45 Clc(cc1Cl)cc(Cl)c1O 933-78-8 2,3,5-TRICHLORPHENOL C6H3Cl3O 197.45 Clc(cc1O)cc(Cl)c1Cl 95-95-4 2,4,5-TRICHLORPHENOL C6H3Cl3O 197.45 Oc1cc(Cl)c(Cl)cc1Cl 609-19-8 3,4,5-TRICHLORPHENOL C6H3Cl3O 197.45 Oc(cc1Cl)cc(Cl)c1Cl 1327-53-3 ARSEN-(III)-OXID As2O3 197.84 O1[As]32=[As]1(O3)O2 1558-31-2 METHYLDICHLOROMETHYLDICHLOROSILANE C2H4Cl4Si 197.95 ClC(Cl)[Si](C)(Cl)Cl 703-61-7 2,4-dichloroquinoline C9H5Cl2N 198.05 Clc2nc1ccccc1c(Cl)c2 703-32-2 5,8-dichloroquinoline C9H5Cl2N 198.05 Clc2c1ncccc1c(Cl)cc2 534-52-1 1-HYDROXY-2-METHYL-3,5-DINITROBENZOL C7H6N2O5 198.13Cc1cc(cc(c1O)N(=O)=O)N(=O)=O 59-87-0 nitrofurazone C6H6N4O4 198.14O=N(=O)c1oc(cc1)C=NNC(=O)N 613-75-2 2-(diacetoxymethyl)furan C9H10O5 198.17 CC(OC(OC(C)=O)c1occc1)=O 93-99-2 BENZOESAEUREPHENYLESTER C13H10O2 198.22 O=C(Oc2ccccc2)c1ccccc1 717-21-5 3-(2-furyl)acrylophenone C13H10O2 198.22 O=C(c2ccccc2)C=Cc1occc1 92-92-2 4-BIPHENYLCARBONSAEURE C13H10O2 198.22 OC(=O)c2ccc(cc2)c1ccccc1 495-48-7 DIPHENYLDIAZEN1-OXID C12H10N2O 198.22 O=N(c2ccccc2)=Nc1ccccc1 103-50-4 DIBENZYLETHER C14H14O 198.26 O(Cc2ccccc2)Cc1ccccc1 6582-52-1 2,2`-DIAMINODIPHENYLMETHAN C13H14N2 198.26 Nc1ccccc1Cc2ccccc2N 75-62-7 TRICHLORBROMMETHAN CBrCl3 198.27 ClC(Cl)(Cl)Br 261-31-4 9H-THIOXANTHEN C13H10S 198.29 C3c1ccccc1Sc2ccccc32 7372-88-5 DIBENZOTHIOPHENE,4-METHYL- C13H10S 198.29 Cc2cccc3c1ccccc1sc32 65423-25-8 dodec-11-enoic acid C12H22O2 198.30 OC(CCCCCCCCCC=C)=O 40923-64-6 3-heptyl-5-methyloxolan-2-one C12H22O2 198.30 CCCCCCCC1CC(C)OC1=O 7492-67-3 2-(3,7-dimethyloct-6-enoxy)acetaldehyde C12H22O2 198.30 CC(CCOCC=O)CCC=C(C)C 2305-05-7 5-octyloxolan-2-one C12H22O2 198.30 CCCCCCCCC1OC(CC1)=O 7774-47-2 5,5-dibutyloxolan-2-one C12H22O2 198.30 CCCCC1(CCCC)OC(CC1)=O 16429-21-3 7-hexyloxepan-2-one C12H22O2 198.30 CCCCCCC1OC(CCCC1)=O 713-95-1 6-heptyloxan-2-one C12H22O2 198.30 CCCCCCCC1OC(CCC1)=O

Page 95 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 86-89-5 1-PENTYLNAPHTHALIN C15H18 198.30 CCCCCc2c1ccccc1ccc2 100-99-2 TRIS(2-METHYLPROPYL)ALUMINIUM C12H27Al 198.33 CC(C)C[Al](CC(C)C)CC(C)C 593-08-8 2-TRIDECANON C13H26O 198.35 CCCCCCCCCCCC(C)=O 462-18-0 7-TRIDECANON C13H26O 198.35 CCCCCCC(CCCCCC)=O 10486-19-8 TRIDECANAL C13H26O 198.35 CCCCCCCCCCCCC=O 74962-98-4 tridec-2-en-1-ol C13H26O 198.35 CCCCCCCCCCC=CCO 7133-46-2 DICYCLOHEXYLSULFID C12H22S 198.37 C(CC2)CCC2SC1CCCCC1 57297-82-2 3-ethyldodecane C14H30 198.39 CCCCCCCCCC(CC)CC 1560-96-9 2-METHYLTRIDECAN C14H30 198.39 CCCCCCCCCCCC(C)C 629-59-4 TETRADECAN C14H30 198.39 CCCCCCCCCCCCCC 6515-38-4 hydroxy-3,5,6-trichloropyridine C5H2Cl3NO 198.44 Oc1nc(Cl)c(Cl)cc1Cl 587-34-8 N-(3-CHLOROPHENYL)-N,N-DIMETHYL-UREA C9H11ClN2O 198.65 Clc1cc(ccc1)NC(=O)N(C)C 150-68-5 N-(4-CHLORPHENYL)-NO,NO-DIMETHYLHARNSTOFF C9H11ClN2O 198.65 Clc1ccc(cc1)NC(=O)N(C)C 2530-87-2 SILANE,(3-CHLOROPROPYL)TRIMETHOXY- C6H15ClO3Si 198.72 ClCCC[Si](OC)(OC)OC 4667-99-6 chloro-triethoxysilane C6H15ClO3Si 198.72 CCO[Si](Cl)(OCC)OCC 24589-78-4 mstfa C6H12F3NOSi 199.25C[Si](C)(C)N(C)C(C(F)(F)F)=O 92-84-2 10H-PHENOTHIAZIN C12H9NS 199.27 c(ccc1sc2ccccc2[nH]3)cc31 59300-35-5 S-ETHYL-BUTYL-2-PROPINYL-THIOCARBAMINSAEUREESTERC10H17NOS 199.31 CCCCN(CC#C)C(SCC)=O 1120-16-7 DODECANSAEUREAMID C12H25NO 199.33 CCCCCCCCCCCC(=O)N 14433-76-2 N,N-DIMETHYLDECANAMID C12H25NO 199.33 CCCCCCCCCC(=O)N(C)C 99-47-8 2-CHLOR-3-NITROACETOPHENON C8H6ClNO3 199.59 ClC(=O)Cc1cc(ccc1)N(=O)=O 360-89-4 1,1,1,2,3,4,4,4-OCTAFLUOR-2-BUTEN C4F8 200.03 FC(F)(F)C(F)=C(F)C(F)(F)F 115-25-3 OCTAFLUORCYCLOBUTAN C4F8 200.03 FC1(F)C(F)(F)C(F)(F)C1(F)F 94247-15-1 heptafluoropropylmethylether C4H3F7O 200.06 COC(F)(F)C(F)(F)C(F)(F)F 375-03-1 HEPTAFLUOROPROPYLMETHYLETHER C4H3F7O 200.06 COC(F)(F)C(F)(F)C(F)(F)F 771-62-0 pentafluorothiophenol C6HF5S 200.13 Fc1c(F)c(F)c(S)c(F)c1F 14595-35-8 (2E)-2-BUTENDISAEUREDIPROPYLESTER C10H16O4 200.23 CCCOC(=O)C=CC(OCCC)=O 2432-63-5 DIPROPYLMALEAT C10H16O4 200.23 CCCOC(=O)C=CC(OCCC)=O 94-60-0 1,4-CYCLOHEXANEDICARBOXYLICACID,DIMETHYLESTER C10H16O4 200.23COC(C1CCC(CC1)C(OC)=O)=O 101-80-4 BIS-(4-AMINOPHENYL)-ETHER C12H12N2O 200.24 Nc1ccc(Oc(cc2)ccc2N)cc1 710-15-6 phenethylsulfamide C8H12N2O2S 200.26 O=S(=O)(N)NCCc1ccccc1 262-20-4 PHENOXATIIN C12H8OS 200.26 O3c1ccccc1Sc2ccccc32 5766-79-0 ALPHA-PHENYL-1-PIPERIDINACETONITRIL C13H16N2 200.28 N#CC(N2CCCCC2)c1ccccc1 10484-56-7 2-butoxynaphthalene C14H16O 200.28 CCCCOc2cc1ccccc1cc2 112-17-4 ESSIGSAEUREDECYLESTER C12H24O2 200.32 CCCCCCCCCCOC(C)=O 6378-65-0 HEXANSAEUREHEXYLESTER C12H24O2 200.32 CCCCCCOC(CCCCC)=O 143-07-7 DODECANSAEURE C12H24O2 200.32 CCCCCCCCCCCC(O)=O 295-37-4 1,4,8,11-TETRAAZACYCLOTETRADECAN C10H24N4 200.33 C1NCCCNCCNCCCNC1 25116-80-7 piperidine,1,1'-thiobis- C10H20N2S 200.35 C(CC1)CCN1SN2CCCCC2 112-70-9 1-TRIDECANOL C13H28O 200.36 OCCCCCCCCCCCCC 51655-57-3 1-NONANOL,2-BUTYL- C13H28O 200.36 CCCCCCCC(CO)CCCC 22663-61-2 1-DODECANOL,2-METHYL- C13H28O 200.36 CCCCCCCCCCC(C)CO 41902-42-5 TRI-TERT.-BUTYLMETHANOL C13H28O 200.36CC(C)(C)C(O)(C(C)(C)C)C(C)(C)C 3011-89-0 2-chloro-4-nitrobenzamide C7H5ClN2O3 200.58 Clc1cc(ccc1C(=O)N)N(=O)=O 101-10-0 2-(3-chlorophenoxy)propanoic acid C9H9ClO3 200.62 CC(C(O)=O)Oc(ccc1)cc1Cl 25277-05-8 (3-chloro-4-methoxyphenyl)urea C8H9ClN2O2 200.62 COc1ccc(cc1Cl)NC(=O)N 586-76-5 4-BROMBENZOESAEURE C7H5BrO2 201.02 OC(=O)c(cc1)ccc1Br 88-65-3 2-BROMBENZOESAEURE C7H5BrO2 201.02 OC(=O)c1ccccc1Br 585-76-2 3-BROMBENZOESAEURE C7H5BrO2 201.02 OC(=O)c(ccc1)cc1Br 138-41-0 4-aminosulfonylbenzoicacid C7H7NO4S 201.20OC(=O)c1ccc(cc1)S(=O)(=O)N 63-25-2 1-NAPHTHALENOLMETHYLCARBAMAT C12H11NO2 201.22 CNC(Oc2c1ccccc1ccc2)=O 715-99-1 1-phenyl-3,5-dimethyl-4-nitrosopyrazole C11H11N3O 201.23 Cc2nn(c1ccccc1)c(C)c2N=O 148-79-8 2-(thiazol-4-yl)benzimidazole C10H7N3S 201.25 c(scc3c2[nH]c1ccccc1n2)n3 122-34-9 2-CHLOR-4,6-BIS-(ETHYLAMINO)-1,3,5-TRIAZIN C7H12ClN5 201.66 CCNc1nc(Cl)nc(NCC)n1 78-75-1 1,2-DIBROMPROPAN C3H6Br2 201.89 BrCC(C)Br 577-19-5 2-BROMNITROBENZOL C6H4BrNO2 202.01 Brc1cc(ccc1)N(=O)=O 586-78-7 4-BROMNITROBENZOL C6H4BrNO2 202.01 Brc1ccc(cc1)N(=O)=O 98-05-5 phenylarsonicacid C6H7AsO3 202.04 O[As](O)(c1ccccc1)=O 41394-05-2 metamitron C10H10N4O 202.21CC2=NN=C(c1ccccc1)C(=O)N2N 2050-60-4 ETHANDISAEUREDIBUTYLESTER C10H18O4 202.25 CCCCOC(=O)C(OCCCC)=O 111-20-6 DECANDISAEURE C10H18O4 202.25 OC(CCCCCCCCC(O)=O)=O 759-36-4 (1-methylethyl)propanedioicaciddiethylester C10H18O4 202.25CCOC(C(C(C)C)C(OCC)=O)=O

Page 96 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 206-44-0 FLUORANTHEN C16H10 202.25 c(ccc1c4c2c3ccc4)cc1c2ccc3 129-00-0 PYREN C16H10 202.25 c(cc4c1c2c3cccc2cc4)cc1cc3 945-51-7 DIPHENYLSULFOXID C12H10OS 202.27 O=S(c2ccccc2)c1ccccc1 30545-23-4 OCTAHYDRO-3,5,1,7-(1,2,3,4)BUTANTETRAYLNAPHTHALIN-2(1H)-ONC14H18O 202.29O=C4C2C5CC(CC31)CC2C1CC4CC53 76-01-7 PENTACHLORETHAN C2HCl5 202.30 ClC(Cl)C(Cl)(Cl)Cl 998-40-3 TRIBUTYLPHOSPHIN C12H27P 202.32 CCCCP(CCCC)CCCC 26460-76-4 DECAHYDRO-1-METHYL-3,5,1,7-(1,2,3,4)BUTANTETRAYLNAPHTHALINC15H22 202.34CC43C2CC(CC51)CC4C1CC(CC52)C3 30545-28-9 DECAHYDRO-2-METHYL-3,5,1,7-(1,2,3,4)BUTANTETRAYLNAPHTHALINC15H22 202.34CC43CC5C1CC(CC5C2C4)CC2C1C3 25103-58-6 TERT.-DODECANTHIOL C12H26S 202.40 SCCCCCCCCC(C)(C)C 112-55-0 1-DODECANTHIOL C12H26S 202.40 CCCCCCCCCCCCS 97-00-7 1-CHLOR-2,4-DINITROBENZOL C6H3ClN2O4 202.55Clc1ccc(cc1N(=O)=O)N(=O)=O 99-63-8 ISOPHTHALSAEUREDICHLORID C8H4Cl2O2 203.02 ClC(=O)c1cc(C(Cl)=O)ccc1 100-20-9 1,4-BENZOLDICARBONYLDICHLORID C8H4Cl2O2 203.02 ClC(=O)c1ccc(C(Cl)=O)cc1 351-36-0 N-(3-(TRIFLUORMETHYL)PHENYL)ACETAMID C9H8F3NO 203.16 FC(F)(F)c1cc(ccc1)NC(C)=O 2401-73-2 1,3-DICHLORO-1,1,3,3-TETRAMETHYLDISILOXAN C4H12Cl2OSi2 203.22 C[Si](C)(Cl)O[Si](C)(C)Cl 1929-77-7 vernolate C10H21NOS 203.35 CCCSC(=O)N(CCC)CCC 1114-71-2 pebulate C10H21NOS 203.35 CCCCN(CC)C(SCCC)=O 76-11-9 1,1-DIFLUORTETRACHLORETHAN C2Cl4F2 203.83 FC(F)(Cl)C(Cl)(Cl)Cl 76-12-0 1,2-DIFLUORTETRACHLORETHAN C2Cl4F2 203.83 FC(Cl)(Cl)C(F)(Cl)Cl 591-50-4 IODBENZOL C6H5I 204.01 Ic1ccccc1 2150-93-8 3',4'-dichloroacetanilide C8H7Cl2NO 204.05 Clc1ccc(cc1Cl)NC(C)=O 1311-87-1 (3-trifluoromethylphenyl)-urea C8H7F3N2O 204.15 FC(F)(F)c1cc(ccc1)NC(=O)N 6118-65-6 3-ACETAMIDOPHTHALIMID C10H8N2O3 204.18CC(=O)Nc1cccc2c1C(=O)NC2=O 1518-16-7 7,7,8,8-TETRACYAN-1,4-CHINODIMETHAN C12H4N4 204.19N#CC(C#N)=C1C=CC(=C(C#N)C#N)C=C1 54-12-6 DL-TRYPTOPHAN C11H12N2O2 204.23[NH3+]C(Cc1c[nH]c2c1cccc2)C([O-])=O 1115-20-4 PROPANOICACID,3-HYDROXY-2,2-DIMETHYL-,3-HYDROXY-2,2-DIMETHYLPROPYLESTERC10H20O4 204.26OCC(C)(C)COC(C(C)(C)CO)=O 124-17-4 BUTYLDIGLYKOLACETAT C10H20O4 204.26 CCCCOCCOCCOC(C)=O 13140-89-1 1-cyclopentyl-3-phenylurea C12H16N2O 204.27 O=C(NC1CCCC1)Nc2ccccc2 605-02-7 1-PHENYLNAPHTHALIN C16H12 204.27 c(cc1)ccc1c3c2ccccc2ccc3 7492-37-7 3-(phenylmethyl)heptan-4-one C14H20O 204.31 CCCC(C(CC)Cc1ccccc1)=O 30651-03-7 OCTAHYDRO-3,5,1,7-(1,2,3,4)BUTANTETRAYLNAPHTHALIN-3(2H)-OLC14H20O 204.31OC43CC2C5CC(CC1C5C4)CC2C1C3 79808-30-3 1,3-di-tert-butyl-glycerin C11H24O3 204.31 OC(COC(C)(C)C)COC(C)(C)C 30545-14-3 diamantan-1-ol C14H20O 204.31OC43C2CC(CC51)CC4C1CC(CC52)C3 30545-24-5 DECAHYDRO-3,5,1,7-(1,2,3,4)BUTANTETRAYLNAPHTHALIN-2-OLC14H20O 204.31OC4C3C5CC2CC3C1CC4CC5C1C2 495-62-5 BISABOLEN C15H24 204.35CC(C)=CCCC(C)=C(CC1)CC=C1C 1081-77-2 NONYLBENZOL C15H24 204.35 CCCCCCCCCc1ccccc1 87-44-5 (1R-(1R*,4E,9S*))-4,11,11-TRIMETHYL-8-METHYLENBICYCLO(7.2.0)UNDEC-4-ENC15H24 204.35CC1(C)CC2C1CCC(C)=CCCC2=C 717-74-8 1,3,5-TRIS(1-METHYLETHYL)BENZOL C15H24 204.35CC(C)c1cc(C(C)C)cc(C(C)C)c1 4630-07-3 4a,5-dimethyl-3-prop-1-en-2-yl-2,3,4,5,6,7-hexahydro-1h-naphthaleneC15H24 204.35CC1CCC=C2CCC(CC21C)C(C)=C 88-84-6 1,4-dimethyl-7-propan-2-ylidene-2,3,4,5,6,8-hexahydro-1h-azuleneC15H24 204.35CC2CCC(CC1=C2CCC1C)=C(C)C 31366-25-3 2-(1,3-DITHIOL-2-YLIDEN)-1,3-DITHIOL C6H4S4 204.36 S1C=CSC1=C2SC=CS2 1185-97-3 oo-dimethyldichlorovinylphosphonate C4H7Cl2O3P 204.98 COP(OC)(=O)C=C(Cl)Cl 2327-02-8 (3,4-DICHLOROPHENYL)-HARNSTOFF C7H6Cl2N2O 205.04 Clc1ccc(cc1Cl)NC(=O)N 107-72-2 TRICHLORPENTYLSILAN C5H11Cl3Si 205.59 CCCCC[Si](Cl)(Cl)Cl 133-90-4 3-AMINO-2,5-DICHLORBENZOESAEURE C7H5Cl2NO2 206.03 OC(=O)c(cc(Cl)cc1N)c1Cl 2809-21-4 1-HYDROXYETHAN-1,1-DIPHOSPHONSAEURE C2H8O7P2 206.03 OC(C)(P(O)(O)=O)P(O)(O)=O 1918-13-4 2,6-dichlorothiobenzamide C7H5Cl2NS 206.09 Clc1cccc(Cl)c1C(N)=S 57968-71-5 butanedioicacid,2,3-dihydroxy-,diethylester,( C8H14O6 206.19CCOC(C(O)C(O)C(OCC)=O)=O 15721-10-5 4-((2-METHYL-1-OXO-2-PROPENYL)OXY)BENZOESAEURE C11H10O4 206.20OC(=O)c1ccc(cc1)OC(=O)C(C)=C 128478-71-7 2-NITROTRICYCLO(3.3.1.1(3,7))DECAN-2-CARBONITRIL C11H14N2O2 206.24N#CC3(C(CC2C1)CC1CC3C2)N(=O)=O 718-36-5 2-METHYL-N-((4-NITROPHENYL)METHYLEN)-2-PROPANAMINC11H14N2O2 206.24CC(C)(C)N=Cc1ccc(cc1)N(=O)=O 3572-06-3 [4-(3-oxobutyl)phenyl] acetate C12H14O3 206.24CC(CCc1ccc(OC(C)=O)cc1)=O 886-38-4 2,3-DIPHENYLCYCLOPROP-2-EN-1-ON C15H10O 206.24O=C1C(c3ccccc3)=C1c2ccccc2 1646-87-3 aldicarbsulfoxide C7H14N2O3S 206.26CC(C)(C=NOC(=O)NC)S(C)=O 15687-27-1 IBUPROFEN C13H18O2 206.28CC(C)Cc1ccc(C(C)C(O)=O)cc1 25498-49-1 DOWANOL_TPM C10H22O4 206.28 COC(C)COC(C)COC(C)CO 143-22-6 BUTYLTRIGLYKOL C10H22O4 206.28 OCCOCCOCCOCCCC 10213-77-1 2-2-(2-methoxypropoxy)propoxy-1-propanol C10H22O4 206.28 COC(C)COC(C)COC(C)CO 538-81-8 TRANS,TRANS-1,4-DIPHENYL-1,3-BUTADIEN C16H14 206.28 c(cc1)ccc1C=CC=Cc2ccccc2 604-83-1 9,10-DIMETHYLPHENANTHREN C16H14 206.28 Cc3c2ccccc2c1ccccc1c3C 781-43-1 9,10-DIMETHYLANTHRACEN C16H14 206.28 Cc3c1ccccc1c(C)c2ccccc32 1576-69-8 2,7-DIMETHYLPHENANTHREN C16H14 206.28 Cc(ccc1c2ccc(C)cc2c3)cc1c3

Page 97 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 3674-69-9 4,5-DIMETHYLPHENANTHREN C16H14 206.28 Cc1cccc(cc3)c1c2c3cccc2C 1138-52-9 3,5-BIS(1,1-DIMETHYLETHYL)PHENOL C14H22O 206.33CC(C)(C)c(c1)cc(C(C)(C)C)cc1O 7784-98-7 (e)-1-(2,6,6-trimethyl-1-cyclohex-3-enyl)pent-1-en-3-one C14H22O 206.33CC1(C)CC=CC(C)C1C=CC(CC)=O 79-69-6 (e)-4-[(1s,5r)-2,5,6,6-tetramethyl-1-cyclohex-2-enyl]but-3-en-2-oneC14H22O 206.33CC1CC=C(C)C(C1(C)C)C=CC(C)=O 140-66-9 4-(1,1,3,3-TETRAMETHYLBUTYL)-PHENOL C14H22O 206.33CC(C)(C)CC(C)(C)c(cc1)ccc1O 127-43-5 BETA-N-METHYLJONON C14H22O 206.33CCC(=O)C=CC1=C(C)CCCC1(C)C 5875-45-6 2,5-DI-TERT.-BUTYLPHENOL C14H22O 206.33CC(C)(C)c(ccc1C(C)(C)C)cc1O 96-76-4 2,4-DI-TERT.-BUTYLPHENOL C14H22O 206.33CC(C)(C)c(ccc1O)cc1C(C)(C)C 128-39-2 2,6-BIS(1,1-DIMETHYLETHYL)PHENOL C14H22O 206.33CC(C)(C)c1cccc(C(C)(C)C)c1O 2051-04-9 BIS(3-METHYLBUTYL)DISULFID C10H22S2 206.41 CC(C)CCSSCCC(C)C 7789-33-5 IODBROMID BrI 206.81 IBr 3401-80-7 3,6-dichloro-2-hydroxybenzoicacid C7H4Cl2O3 207.01 OC(=O)c(c(Cl)ccc1Cl)c1O 2675-77-6 1,4-DICHLOR-2,5-DIMETHOXYBENZOL C8H8Cl2O2 207.06 COc1cc(Cl)c(OC)cc1Cl 580-13-2 2-NAPHTHYLBROMID C10H7Br 207.07 Brc2cc1ccccc1cc2 90-11-9 1-BROMNAPHTHALIN C10H7Br 207.07 Brc2c1ccccc1ccc2 88-30-2 4-NITRO-3-(TRIFLUORMETHYL)PHENOL C7H4F3NO3 207.11 FC(F)(F)c1cc(O)ccc1N(=O)=O 63075-06-9 pentyl-n-phenylcarbamate C12H17NO2 207.27 CCCCCOC(=O)Nc1ccccc1 780-11-0 m-t-butylphenyl-n-methylcarbamate C12H17NO2 207.27CC(C)(C)c1cc(OC(=O)NC)ccc1 3766-81-2 2-(1-methylpropyl)-phenolmethylcarbamate C12H17NO2 207.27 CCC(C)c1ccccc1OC(=O)NC 1502-00-7 N,N-DIMETHYLTRICYCLO(3.3.1.1(3,7))DECAN-1-CARBOXAMIDC13H21NO 207.31CN(C)C(C2(C3)CC(CC3C1)CC1C2)=O 541-25-3 (2-CHLORETHENYL)ARSENDICHLORID C2H2AsCl3 207.32 Cl[As](Cl)C=CCl 84-65-1 9,10-ANTHRACENDION C14H8O2 208.21O=C3c1ccccc1C(=O)c2ccccc32 581-55-5 PHENYLMETHANDIOLDIACETAT C11H12O4 208.21CC(OC(OC(C)=O)c1ccccc1)=O 84-11-7 9,10-PHENANTHRENCHINON C14H8O2 208.21 O=C3c2ccccc2c1ccccc1C3=O 1017-93-2 BICYCLO(2.2.2)OCT-5-EN-2,2,3,3-TETRACARBONITRIL C12H8N4 208.22N#CC1(C#N)C2CCC(C1(C#N)C#N)C=C2 10026-13-8 PENTACHLORPHOSPHORAN Cl5P 208.24 ClP(Cl)(Cl)(Cl)Cl 23783-42-8 TETRAETHYLENGLYKOLMONOMETHYLETHER C9H20O5 208.25 COCCOCCOCCOCCO 588-68-1 benzaldehyde,(phenylmethylene)hydrazone C14H12N2 208.26 c(cc1)ccc1C=NN=Cc2ccccc2 1468-95-7 9-anthracenemethanol C15H12O 208.26 OCc3c1ccccc1cc2ccccc32 1633-22-3 TRICYCLO[8.2.2.2.]HEXADECA-4,6,10,12,13,15-HEXAE C16H16 208.30 C(Cc2ccc3cc2)c1ccc(CC3)cc1 5385-36-4 (2.2)-METAPARACYCLOPHAN C16H16 208.30 C(Cc2cc(CC3)ccc2)c1ccc3cc1 2319-97-3 (2,2)metacyclophane C16H16 208.30 C(Cc2cc3ccc2)c1cc(CC3)ccc1 78-10-4 KIESELSAEURE(H4SIO4)TETRAETHYLESTER C8H20O4Si 208.33 CCO[Si](OCC)(OCC)OCC 765-13-9 1-PENTADECIN C15H28 208.38 CCCCCCCCCCCCCC#C 2904-59-8 2,4,6-TRIMETHOXYBENZONITRIL-N-OXID C10H11NO4 209.20COc(cc1OC)cc(OC)c1C#[N+][O-] 114-26-1 2-(1-METHYLETHOXY)PHENOLMETHYLCARBAMAT C11H15NO3 209.24 CC(C)Oc1ccccc1OC(=O)NC 75-61-6 DIBROMDIFLUORMETHAN CBr2F2 209.82 FC(F)(Br)Br 3141-12-6 ARSENIGESAEURETRIETHYLESTER C6H15AsO3 210.10 CCO[As](OCC)OCC 554-95-0 1,3,5-BENZOLTRICARBONSAEURE C9H6O6 210.14OC(=O)c1cc(C(O)=O)cc(C(O)=O)c1 528-44-9 1,2,4-BENZOLTRICARBONSAEURE C9H6O6 210.14OC(=O)c(ccc1C(O)=O)cc1C(O)=O 3173-72-6 1,5-DIISOCYANATONAPHTHALIN C12H6N2O2 210.19O=C=Nc2cccc1c2cccc1N=C=O 134-81-6 BENZIL C14H10O2 210.23 O=C(c1ccccc1)C(c2ccccc2)=O 69155-29-9 4,5-DIMETHYL-4-CYCLOHEXEN-1,1,2,2-TETRACARBONITRILC12H10N4 210.24N#CC1(C#N)CC(C)=C(C)CC1(C#N)C#N 82654-98-6 4-(butoxymethyl)-2-methoxyphenol C12H18O3 210.27 CCCCOCc(ccc1O)cc1OC 102-04-5 1,3-DIPHENYL-2-PROPANON C15H14O 210.27 O=C(Cc2ccccc2)Cc1ccccc1 55290-64-7 2,3-dimethyl-5,6-dihydro-1,4-dithiine 1,1,4,4-tetraoxide C6H10O4S2 210.27CC1=C(C)S(CCS1(=O)=O)(=O)=O 10435-68-4 4,5,6-trimethyl-2,3-benzoxalene C15H14O 210.27CC(OC2=Cc1ccccc1C2=C3C)=C3C 16192-04-4 1-METHYL-4-(2-METHYL-2-PROPENYLSULFONYL)BENZOL C11H14O2S 210.29CC(=C)CS(c(cc1)ccc1C)(=O)=O 17482-19-8 1-(3-BUTENYL)-4-METHYLBENZOL C11H14O2S 210.29 C=CCCS(c(cc1)ccc1C)(=O)=O 16192-03-3 1-METHYL-4-((2-METHYL-1-PROPENYL)SULFONYL)BENZOLC11H14O2S 210.29Cc1ccc(cc1)S(=O)(=O)C=C(C)C 24931-66-6 1-(2-BUTENYLSULFONYL)-4-METHYLBENZOL C11H14O2S 210.29 CC=CCS(c(cc1)ccc1C)(=O)=O 625-22-9 SCHWEFELSAEUREDIBUTYLESTER C8H18O4S 210.29 CCCCOS(OCCCC)(=O)=O 1520-44-1 1,3-DIPHENYLBUTAN C16H18 210.32 CC(CCc1ccccc1)c2ccccc2 719-79-9 1,1-DIPHENYLBUTAN C16H18 210.32 CCCC(c2ccccc2)c1ccccc1 7439-15-8 BENZENE,1-ETHYL-4-(2PHENYLETHYL)- C16H18 210.32 CCc2ccc(CCc1ccccc1)cc2 64800-83-5 ethyl(phenylethyl)-benzene C16H18 210.32 CCc2ccc(CCc1ccccc1)cc2 3445-76-9 5-phenyl-3h-1,2-dithiole-3-thione C9H6S3 210.34 [S-]C(=[S+]S2)C=C2c1ccccc1 775-56-4 DIETHOXYMETHYLPHENYLSILAN C11H18O2Si 210.35 CCO[Si](C)(OCC)c1ccccc1 3603-99-4 CYCLOTETRADECANON C14H26O 210.36 O=C1CCCCCCCCCCCCC1 13360-61-7 1-PENTADECEN C15H30 210.40 CCCCCCCCCCCCCC=C 74392-36-2 TRANS-2-PENTADECENE C15H30 210.40 CCCCCCCCCCCCC=CC 1795-21-7 DECYLCYCLOPENTAN C15H30 210.40 CCCCCCCCCCC1CCCC1

Page 98 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 295-48-7 CYCLOPENTADECAN C15H30 210.40 C1CCCCCCCCCCCCCC1 675-62-7 3,3,3-TRIFLUORPROPYLMETHYLDICHLORSILAN C4H7Cl2F3Si 211.09 FC(F)(F)CC[Si](C)(Cl)Cl 121-81-3 3,5-dinitrobenzamide C7H5N3O5 211.13O=N(=O)c1cc(cc(c1)N(=O)=O)C(=O)N 55861-78-4 isouron C10H17N3O2 211.26CC(C)(C)c1cc(no1)NC(=O)N(C)C 519-87-9 N,N-DIPHENYLACETAMID C14H13NO 211.26 CC(=O)N(c2ccccc2)c1ccccc1 1610-17-9 2-METHOXY-4-ETHYLAMINO-6-ISOPROPYLAMINO-1,3,5-TRIAZINC9H17N5O 211.27 CCNc(n1)nc(NC(C)C)nc1OC 634-85-5 2,3,5-TRICHLOR-2,5-CYCLOHEXADIEN-1,4-DION C6HCl3O2 211.43ClC(=CC1=O)C(=O)C(Cl)=C1Cl 98-13-5 TRICHLORPHENYLSILAN C6H5Cl3Si 211.55 Cl[Si](Cl)(Cl)c1ccccc1 1918-16-7 2-CHLOR-N-(1-METHYLETHYL)-N-PHENYLACETAMID C11H14ClNO 211.69 CC(C)N(c1ccccc1)C(CCl)=O 2550-06-3 1-(TRICHLORSILYL)-3-CHLORPROPAN C3H6Cl4Si 211.98 ClCCC[Si](Cl)(Cl)Cl 602-94-8 PENTAFLUORBENZOESAEURE C7HF5O2 212.07 OC(=O)c(c(F)c1F)c(F)c(F)c1F 638-45-9 HEXYLIODID C6H13I 212.07 CCCCCCI 99-34-3 3,5-DINITROBENZOESAEURE C7H4N2O6 212.12OC(=O)c1cc(cc(c1)N(=O)=O)N(=O)=O 528-45-0 3,4-DINITROBENZOESAEURE C7H4N2O6 212.12OC(=O)c(ccc1N(=O)=O)cc1N(=O)=O 712-68-5 triafur C6H4N4O3S 212.19 Nc2sc(nn2)c1oc(cc1)N(=O)=O 120-51-4 BENZOESAEUREPHENYLMETHYLESTER C14H12O2 212.25 O=C(OCc2ccccc2)c1ccccc1 119-53-9 2-hydroxy-1,2-di(phenyl)ethanone C14H12O2 212.25 OC(C(=O)c2ccccc2)c1ccccc1 102-07-8 1,1-DIPHENYLHARNSTOFF C13H12N2O 212.25 O=C(Nc2ccccc2)Nc1ccccc1 492-22-8 9H-THIOXANTHEN-9-ONE C13H8OS 212.27 O=C3c1ccccc1Sc2ccccc32 599-64-4 4-(2-PHENYL-2-PROPYL)-PHENOL C15H16O 212.29 CC(C)(c1ccccc1)c(cc2)ccc2O 1207-12-1 DIBENZOTHIOPHENE,4,6-DIMETHYL- C14H12S 212.31 Cc1cccc3c1sc2c3cccc2C 53398-90-6 2,6,6,10-tetramethyl-1-oxaspiro[4.5]decan-10-ol C13H24O2 212.33CC(CC1)OC21C(C)(C)CCCC2(O)C 2876-53-1 1-HEXYLNAPHTHALIN C16H20 212.33 CCCCCCc2c1ccccc1ccc2 2345-27-9 2-TETRADECANON C14H28O 212.37 CCCCCCCCCCCCC(C)=O 75853-49-5 12-methyltridecanal C14H28O 212.37 CC(C)CCCCCCCCCCC=O 124-25-4 TETRADECANAL C14H28O 212.37 CCCCCCCCCCCCCC=O 629-62-9 PENTADECAN C15H32 212.42 CCCCCCCCCCCCCCC 15545-48-9 CHLORTOLURON C10H13ClN2O 212.68 Cc1ccc(cc1Cl)NC(=O)N(C)C 99-35-4 1,3,5-TRINITROBENZOL C6H3N3O6 213.11O=N(=O)c1cc(cc(c1)N(=O)=O)N(=O)=O 20357-59-9 2-((OXIDOPHENYLIMINO)METHYL)PHENOL C13H11NO2 213.23 Oc2ccccc2C=N(c1ccccc1)=O 1014-70-6 2-METHYLTHIO-4,6-BIS-(ETHYLAMINO)-1,3,5-TRIAZIN C8H15N5S 213.30 CCNc1nc(SC)nc(NCC)n1 1014-69-3 desmetryn C8H15N5S 213.30 CC(C)Nc(n1)nc(SC)nc1NC 27563-67-3 N-METHYLDODECANSAEIREAMID C13H27NO 213.36 CCCCCCCCCCCC(=O)NC 2016-42-4 1-TETRADECANAMIN C14H31N 213.40 NCCCCCCCCCCCCCC 608-94-6 TRICHLORHYDROCHINON C6H3Cl3O2 213.45 Oc(cc1Cl)c(Cl)c(Cl)c1O 375-22-4 PERFLUORBUTTERSAEURE C4HF7O2 214.04FC(F)(F)C(F)(F)C(F)(F)C(O)=O 773-76-2 5,7-DICHLOR-8-CHINOLINOL C9H5Cl2NO 214.05 Clc2cc(Cl)c1cccnc1c2O 621-38-5 3-bromoacetanilide C8H8BrNO 214.06 Brc1cc(ccc1)NC(C)=O 103-88-8 N-(4-BROMPHENYL)ACETAMID C8H8BrNO 214.06 Brc1ccc(cc1)NC(C)=O 402-31-3 1,3-BIS-(TRIFLUORMETHYL)-BENZOL C8H4F6 214.11 FC(F)(F)c1cc(C(F)(F)F)ccc1 118-55-8 2-HYDROXYBENZOESAEUREPHENYLESTER C13H10O3 214.22 Oc2ccccc2C(Oc1ccccc1)=O 102-09-0 KOHLENSAEUREDIPHENYLESTER C13H10O3 214.22 O=C(Oc2ccccc2)Oc1ccccc1 119-75-5 2-NITRODIPHENYLAMIN C12H10N2O2 214.22 O=N(=O)c2ccccc2Nc1ccccc1 836-30-6 4-NITRODIPHENYLAMIN C12H10N2O2 214.22 O=N(=O)c(cc2)ccc2Nc1ccccc1 131-56-6 (2,4-DIHYDROXYPHENYL)PHENYLMETHANON C13H10O3 214.22 Oc(ccc2C(=O)c1ccccc1)cc2O 21282-97-3 BUTANOICACID,3-OXY-,2-[(2-METHYL-1-OXO-2-PROPENYL)OXYL]ETHYLESTERC10H14O5 214.22CC(CC(OCCOC(=O)C(C)=C)=O)=O 104-66-5 1,2-diphenoxyethane C14H14O2 214.26 C(COc1ccccc1)Oc2ccccc2 21087-64-9 4-AMINO-6-(1,1-DIMETHYLETHYL)-3-(METHYLTHIO)-1,2,4-TRIAZIN-5(4H)-ONC8H14N4OS 214.29CC(C)(C)C1=NN=C(SC)N(N)C1=O 10039-39-1 (5-hexyloxolan-3-yl) acetate C12H22O3 214.30CCCCCCC1CC(CO1)OC(C)=O 538-74-9 DIBENZYLSULFID C14H14S 214.33 S(Cc2ccccc2)Cc1ccccc1 778-25-6 methyldiphenylsilanol C13H14OSi 214.34 O[Si](C)(c2ccccc2)c1ccccc1 111-82-0 DODECANSAEUREMETHYLESTER C13H26O2 214.35 CCCCCCCCCCCC(OC)=O 50623-57-9 NONANSAEUREBUTYLESTER C13H26O2 214.35 CCCCCCCCC(OCCCC)=O 638-53-9 TRIDECANSAEURE C13H26O2 214.35 CCCCCCCCCCCCC(O)=O 112-72-1 1-TETRADECANOL C14H30O 214.39 OCCCCCCCCCCCCCC 21078-81-9 2-BUTYL-1-DECANOL C14H30O 214.39 CCCCCCCCC(CO)CCCC 32480-16-3 1-TRIDECANOL,2-METHYL C14H30O 214.39 CCCCCCCCCCCC(C)CO 10038-98-9 TETRACHLORGERMAN Cl4Ge 214.45 Cl[Ge](Cl)(Cl)Cl 1746-81-2 N`-(4-CHLORPHENYL)-N-METHOXY-N-METHYLHARNSTOFFC9H11ClN2O2 214.65 CON(C)C(=O)Nc(cc1)ccc1Cl 20782-57-4 1-(3-chloro-4-methoxyphenyl)-3-methylurea C9H11ClN2O2 214.65 COc1ccc(cc1Cl)NC(=O)NC 41992-17-0 1,1-diethylgermacyclohexan-4-one C9H18GeO 214.88 CC[Ge]1(CC)CCC(CC1)=O 320-60-5 BENZENE,2,4-DICHLORO-1-(TRIFLUOROMETHYL)- C7H3Cl2F3 215.00 FC(F)(F)c1ccc(Cl)cc1Cl

Page 99 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 1967-25-5 (4-bromophenyl)urea C7H7BrN2O 215.05 Brc1ccc(cc1)NC(=O)N 2989-98-2 3-bromophenylurea C7H7BrN2O 215.05 Brc1cc(ccc1)NC(=O)N 1134-23-2 cycloate C11H21NOS 215.36 CCSC(=O)N(CC)C1CCCCC1 1912-24-9 ATRAZIN_(2-CHLOR-4-ETHYLAMINO-6-ISOPROPYLAMINO-1,3,5-TRIAZINC8H14ClN5 215.68 CCNc1nc(NC(C)C)nc(Cl)n1 634-66-2 1,2,3,4-TETRACHLORBENZOL C6H2Cl4 215.89 Clc1ccc(Cl)c(Cl)c1Cl 95-94-3 1,2,4,5-TETRACHLORBENZOL C6H2Cl4 215.89 Clc1cc(Cl)c(Cl)cc1Cl 634-90-2 1,2,3,5-TETRACHLORBENZOL C6H2Cl4 215.89 Clc(cc1Cl)cc(Cl)c1Cl 10493-43-3 ETHENE,TRIFLUORO(PENTAFLUOROETHOXY) C4F8O 216.03 FC(F)(F)C(F)(F)OC(F)=C(F)F 326-06-7 4,4,4-TRIFLUOR-1-PHENYL-1,3-BUTANDION C10H7F3O2 216.16FC(F)(F)C(CC(=O)c1ccccc1)=O 298-81-7 methoxsalen C12H8O4 216.19COc3c1occc1cc2C=CC(Oc32)=O 1141-38-4 2,6-NAPHTHALINDICARBONSAEURE C12H8O4 216.19OC(=O)c(ccc1cc2C(O)=O)cc1cc2 50626-02-3 ethyl-2-phenylfuran-3-carboxylate C13H12O3 216.23 CCOC(=O)c2ccoc2c1ccccc1 50980-84-2 1,2-propanedioldibutanoate C11H20O4 216.28CCCC(OCC(C)OC(CCC)=O)=O 2050-20-6 HEPTANDISAEUREDIETHYLESTER C11H20O4 216.28 CCOC(CCCCCC(OCC)=O)=O 205-12-9 7h-benzo(c)fluorene C17H12 216.28C(c1cc2)c4ccc3ccccc3c4c1cc2 238-84-6 11H-BENZO(A)FLUOREN C17H12 216.28 c2cc1Cc4c3ccccc3ccc4c1cc2 77-68-9 PROPANOICACID,2-METHYL-,3-HYDROXY-2,2,4-TRIMETHYLPENTYLESTERC12H24O3 216.32CC(C)C(O)C(C)(C)COC(C(C)C)=O 2388-12-7 DODECANPEROXOSAEURE C12H24O3 216.32 CCCCCCCCCCCC(OO)=O 92-85-3 THIANTHREN C12H8S2 216.32 c(ccc2sc1ccccc1s3)cc32 66325-11-9 NAPHTHALENE,1-HEXYL-1,2,3,4-TETRAHYDRO- C16H24 216.36 CCCCCCC2c1ccccc1CCC2 5902-51-2 terbacil C9H13ClN2O2 216.67CC(C)(C)n(c(=O)[nH]c1C)c(=O)c1Cl 77-21-4 2-ethyl-2-phenylgluterimide C13H15NO2 217.26CCC2(CCC(=O)NC2=O)c1ccccc1 205-25-4 7h-benzo[c]carbazole C16H11N 217.27c(ccc1c3c2ccccc2[nH]c3c4)cc1c4 91-53-2 6-ETHOXY-2,2,4-TRIMETHYL-1,2-DIHYDROCHINOLIN C14H19NO 217.31CCOc(ccc1N2)cc1C(C)=CC2(C)C 919-31-3 PROPANENITRILE,3-(TRIETHOXYSILYL)- C9H19NO3Si 217.34 CCO[Si](OCC)(OCC)CCC#N 2008-41-5 butylate C11H23NOS 217.37 CC(C)CN(CC(C)C)C(SCC)=O 709-98-8 propanil C9H9Cl2NO 218.08 CCC(=O)Nc(ccc1Cl)cc1Cl 89-32-7 BENZOE-1,2,4,5-TETRACARBONSAEUREANHYDRID C10H2O6 218.12O=C3c2cc1c(C(OC1=O)=O)cc2C(O3)=O 102-76-1 GLYCERINTRIACETAT C9H14O6 218.20CC(OCC(COC(C)=O)OC(C)=O)=O 13297-17-1 2-methyl-3-acetyl-quinoxaline1,4-dioxide C11H10N2O3 218.21CC(=O)c2n(=O)c1ccccc1n(=O)c2C 7757-97-3 n-(3-amino-3-oxopropyl)-2,4-dihydroxy-3,3-dimethylbutanamideC9H18N2O4 218.25OCC(C)(C)C(O)C(=O)NCCC(=O)N 243-24-3 BENZ(B)INDENO-(1,2-E)-PYRAN C16H10O 218.25c(ccc3C=C2c1ccccc1C=C2O4)cc43 243-42-5 benzo[b]naphtho[2,3-d]furan C16H10O 218.25 c(ccc1cc3c2ccccc2oc3c4)cc41 127-63-9 DIPHENYLSULFON C12H10O2S 218.27 O=S(c2ccccc2)(c1ccccc1)=O 814-29-9 TRIBUTYLPHOSPHINOXID C12H27OP 218.32 CCCCP(CCCC)(CCCC)=O 112-73-2 DIETHYLENGLYKOLDIBUTYLETHER C12H26O3 218.33 CCCCOCCOCCOCCCC 4674-50-4 4,4a-dimethyl-6-prop-1-en-2-yl-3,4,5,6,7,8-hexahydronaphthalen-2-oneC15H22O 218.34CC2CC(=O)C=C1CCC(CC21C)C(C)=C 882-33-7 DIPHENYLDISULFID C12H10S2 218.34 S(Sc1ccccc1)c2ccccc2 1558-24-3 TRICHLOR(DICHLORMETHYL)SILAN CHCl5Si 218.37 ClC(Cl)[Si](Cl)(Cl)Cl 605-01-6 PENTAETHYLBENZOL C16H26 218.38 CCc1cc(CC)c(CC)c(CC)c1CC 104-72-3 DECYLBENZOL C16H26 218.38 CCCCCCCCCCc1ccccc1 39227-54-8 2-CHLORDIBENZO-(B,E)(1,4)-DIOXIN C12H7ClO2 218.64 Clc(ccc2O3)cc2Oc1ccccc31 39227-53-7 1-CHLORDIBENZO(B,E)(1,4)DIOXIN C12H7ClO2 218.64 Clc2cccc3c2Oc1ccccc1O3 615-43-0 2-IODANILIN C6H6IN 219.02 Nc1ccccc1I 540-37-4 4-IODANILIN C6H6IN 219.02 Nc1ccc(I)cc1 3567-62-2 n-(3,4-dichlorophenyl)-n'-methylurea C8H8Cl2N2O 219.07 Clc1ccc(cc1Cl)NC(=O)NC 23135-22-0 2-(DIMETHYLAMINO)-N-(((METHYLAMINO)CARBONYL)OXY)-2-OXOETHANIMIDOTHIOSAEUREMETHYLC7H13N3O3S 219.26CNC(=O)ON=C(SC)C(=O)N(C)C 90-30-2 N-PHENYL-1-NAPHTHALINAMIN C16H13N 219.28 N(c1ccccc1)c3c2ccccc2ccc3 135-88-6 PHENYL-(2-NAPHTHYL)-AMIN C16H13N 219.28 N(c1ccccc1)c3cc2ccccc2cc3 121678-88-4 2-METHYL-N-((4-(1-METHYLETHYL)PHENYL)METHYLEN)-2-PROPANAMINN-OXIDC14H21NO 219.32CC(C)c1ccc(cc1)C=N(C(C)(C)C)=O 1009-93-4 cyclotrisilazane,2,2,4,4,6,6-hexamethyl- C6H21N3Si3 219.51C[Si]1(C)N[Si](C)(C)N[Si](C)(C)N1 928-65-4 silane,trichlorohexyl- C6H13Cl3Si 219.61 CCCCCC[Si](Cl)(Cl)Cl 533-58-4 2-IODPHENOL C6H5IO 220.01 Oc1ccccc1I 540-38-5 4-IODPHENOL C6H5IO 220.01 Oc1ccc(I)cc1 626-02-8 3-IODPHENOL C6H5IO 220.01 Oc1cc(I)ccc1 536-80-1 iodosylbenzene C6H5IO 220.01 O=Ic1ccccc1 29412-62-2 CUBAN-1,4-DICARBONSAEUREDIMETHYLESTER C12H12O4 COC(C53C2C1C3C4C1(C2C54)C(OC)=O)=O220.22 4253-34-3 methylsilanetrioltriacetate C7H12O6Si 220.25C[Si](OC(C)=O)(OC(C)=O)OC(C)=O 51707-55-2 1-phenyl-3-(thiadiazol-5-yl)urea C9H8N4OS 220.25 O=C(Nc1ccccc1)Nc2snnc2 33100-27-5 1,4,7,10,13-PENTAOXACYCLOPENTADECAN C10H20O5 220.26 C1OCCOCCOCCOCCOC1 784-04-3 1-(9-anthracenyl)ethanone C16H12O 220.27CC(=O)c3c1ccccc1cc2ccccc32 354-56-3 PENTACHLORFLUORETHAN_(F_111) C2Cl5F 220.29 FC(Cl)(Cl)C(Cl)(Cl)Cl

Page 100 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 719-22-2 2,6-bis(t-butyl)-2,5-cyclohexadiene-1,4-dione C14H20O2 220.31CC(C)(C)C1=CC(=O)C=C(C(C)(C)C)C1=O 75899-69-3 PROPANOL,[2-(2-ETHOXYMETHYLETHOXY)-METHYLETHOXY]-C11H24O4 220.31 CCOCC(C)OCC(C)OCC(O)C 20178-34-1 tripropyleneglycolethyletherisomer C11H24O4 220.31 CCOCC(C)OCC(C)OCC(O)C 25154-52-3 NONYLPHENOL C15H24O 220.35 CCCCCCCCCc1ccccc1O 136-83-4 2-nonylphenol C15H24O 220.35 CCCCCCCCCc1ccccc1O 19317-11-4 3,7,11-TRIMETHYL-2,6,10-DODECATRIENAL C15H24O 220.35CC(C)=CCCC(C)=CCCC(C)=CC=O 128-37-0 2,6-BIS(1,1-DIMETHYLETHYL)-4-METHYLPHENOL C15H24O 220.35CC(C)(C)c1cc(C)cc(C(C)(C)C)c1O 283-68-1 tricyclo[8.2.2.24,7]-hexadecane C16H28 220.39C(CC2CCC3CC2)C1CCC(CC3)CC1 662-01-1 1,3-DICHLOR-1,1,2,2,3,3-HEXAFLUORPROPAN C3Cl2F6 220.93 FC(F)(Cl)C(F)(F)C(F)(F)Cl 62-73-7 PHOSPHORSAEURE-2,2-DICHLOROVINYL-DIMETHYLESTERC4H7Cl2O4P 220.98 COP(OC)(OC=C(Cl)Cl)=O 1918-00-9 3,6-DICHLORO-2-METHOXYBENZOESAEURE C8H6Cl2O3 221.04 COc1c(C(O)=O)c(Cl)ccc1Cl 1563-66-2 2,3-DIHYDRO-2,2-DIMETHYL-7-BENZOFURANOLMETHYLCARBAMATC12H15NO3 221.25CC1(C)Oc2c(OC(=O)NC)cccc2C1 18691-97-9 methabenzthiazuron C10H11N3OS 221.28 CNC(=O)N(C)c2sc1ccccc1n2 919-30-2 3-(TRIETHOXYSILYL)-1-PROPANAMIN C9H23NO3Si 221.37 NCCC[Si](OCC)(OCC)OCC 1698-60-8 5-AMINO-4-CHLOR-2-PHENYL-3(2H)-PYRIDAZINON C10H8ClN3O 221.64ClC(=C(N)C=NN2c1ccccc1)C2=O 6012-97-1 TETRACHLORTHIOPHEN C4Cl4S 221.92 Clc1sc(Cl)c(Cl)c1Cl 121-82-4 HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZIN C3H6N6O6 222.12O=N(=O)N1CN(CN(C1)N(=O)=O)N(=O)=O 326-91-0 4,4,4-TRIFLUOR-1-(2-THIENYL)-1,3-BUTANDION C8H5F3O2S 222.19FC(F)(F)C(=O)CC(=O)c1sccc1 15788-02-0 3-buten-2-one,1,1,1-trifluoro-4-hydroxy-4-(2-thie C8H5F3O2S 222.19FC(F)(F)C(=O)C=C(O)c1sccc1 84-66-2 1,2-BENZOLDICARBONSAEUREDIETHYLESTER C12H14O4 222.24CCOC(=O)c1ccccc1C(OCC)=O 3585-88-4 2-METHYL-N-((4-NITROPHENYL)METHYLEN)-2-PROPANAMINEN-OXIDC11H14N2O3 222.24CC(C)(C)N(=O)=Cc1ccc(cc1)N(=O)=O 780-59-6 n-methylallobarbital C11H14N2O3 222.24C=CCC1(CC=C)C(=O)N(C)C(=O)NC1=O 723-62-6 9-ANTHRACENCARBONSAEURE C15H10O2 222.24OC(=O)c3c1ccccc1cc2ccccc32 718-67-2 5-methyl-5-cyclohexylbarbituricacid C11H14N2O3 222.24O=C2NC(=O)NC(C2CC1=CCCCC1)=O 18039-45-7 2,5-DIPHENYL-2H-TETRAZOL C13H10N4 222.25 c(cc1)ccc1c3nn(c2ccccc2)nn3 7477-73-8 1,5-DIPHENYL-1H-TETRAZOL C13H10N4 222.25 c(cc1)ccc1c3nnnn3c2ccccc2 55764-31-3 s-(2,5-dimethylfuran-3-yl)furan-2-carbothioate C11H10O3S 222.26 Cc(oc2C)cc2SC(=O)c1occc1 27607-77-8 methanesulfonicacid,trifluoro-,trimethylsilylester C4H9F3O3SSi 222.26C[Si](C)(C)OS(C(F)(F)F)(=O)=O 143-24-8 2,5,8,11,14-PENTAOXAPENTADECAN C10H22O5 222.28 COCCOCCOCCOCCOC 4098-71-9 CYCLOHEXANE,5-ISOCYANATO-1-(ISOCYANATOMETHYL)-1,3,3-TRIMETHYL-C12H18N2O2 222.28CC1(C)CC(CC(C)(C1)CN=C=O)N=C=O 1020-31-1 3,5-BIS(1,1-DIMETHYLETHYL)-1,2-BENZOLDIOL C14H22O2 222.32CC(C)(C)c(cc1O)cc(C(C)(C)C)c1O 4602-84-0 3,7,11-TRIMETHYLDODECA-2,6,10-TRIEN-1-OL C15H26O 222.37OCC=C(C)CCC=C(C)CCC=C(C)C 7212-44-4 3,7,11-TRIMETHYL-1,6,10-DODECATRIEN-3-OL C15H26O 222.37OC(C)(CCC=C(C)CCC=C(C)C)C=C 77-53-2 cedrol C15H26O 222.37CC1CCC(C2(C)C)C1(CC3)CC2C3(O)C 828-26-2 2,2,4,4,6,6-hexamethyl-1,3,5-trithiane C9H18S3 222.44 CC1(C)SC(C)(C)SC(C)(C)S1 541-05-9 HEXAMETHYLCYCLOTRISILOXAN C6H18O3Si3 222.46C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O1 18721-69-2 tetrahydro-2,5-selenophenedicarboxylicacid C6H8O4Se 223.09 OC(C1[Se]C(CC1)C(O)=O)=O 2050-68-2 4,4`-DICHLORBIPHENYL C12H8Cl2 223.10 Clc2ccc(cc2)c(cc1)ccc1Cl 13029-08-8 2,2`-DICHLOROBIPHENYL C12H8Cl2 223.10 Clc2ccccc2c1ccccc1Cl 34883-43-7 2,4`-DICHLORBIPHENYL C12H8Cl2 223.10 Clc2ccc(cc2)c1ccccc1Cl 16605-91-7 2,3-DICHLORBIPHENYL C12H8Cl2 223.10 Clc2cccc(c1ccccc1)c2Cl 82-45-1 1-AMINOANTHRACHINON C14H9NO2 223.23Nc2cccc3c2C(=O)c1ccccc1C3=O 117-79-3 2-AMINOANTHRACHINON C14H9NO2 223.23Nc(ccc2C3=O)cc2C(=O)c1ccccc31 3246-04-6 n-(3-phenoxy-2-hydroxypropyl)-butylamine C13H21NO2 223.31 CCCCNCC(O)COc1ccccc1 18836-52-7 (2e,4e)-n-(2-methylpropyl)deca-2,4-dienamide C14H25NO 223.36CCCCCC=CC=CC(=O)NCC(C)C 18300-91-9 PENTADECANNITRIL C15H29N 223.40 CCCCCCCCCCCCCCC#N 7786-34-7 3-(DIMETHOXYPHOSPHINATO)-2-BUTENSAEUREMETHYLESTERC7H13O6P 224.15COP(OC)(=O)OC(C)=CC(OC)=O 721-71-1 hydrazinecarboxamide,2-[3-[5-nitro-2-furanyl)-2 C8H8N4O4 224.17O=N(=O)c1oc(cc1)C=CC=NNC(=O)N 129-43-1 1-HYDROXY-9,10-ANTHRACENDION C14H8O3 224.21Oc2cccc3c2C(=O)c1ccccc1C3=O 6050-13-1 diphenicanhydride C14H8O3 224.21O=c3c2ccccc2c1ccccc1c(=O)o3 605-32-3 2-HYDROXY-9,10-ANTHRACENDION C14H8O3 224.21Oc(ccc2C3=O)cc2C(=O)c1ccccc31 120-46-7 1,3-DIPHENYL-1,3-PROPANDION C15H12O2 224.26O=C(CC(=O)c2ccccc2)c1ccccc1 502-72-7 CYCLOPENTADECANON C15H28O 224.38 O=C1CCCCCCCCCCCCCC1 629-73-2 1-HEXADECEN C16H32 224.43 CCCCCCCCCCCCCCC=C 295-65-8 CYCLOHEXADECAN C16H32 224.43 C1CCCCCCCCCCCCCCC1 1795-16-0 DECYLCYCLOHEXAN C16H32 224.43 CCCCCCCCCCC1CCCCC1 22659-18-3 2,2'-selenodipropanoicacid C6H10O4Se 225.10 CC([Se]C(C)C(O)=O)C(O)=O 2168-88-9 3,3'-selenobispropanoicacid C6H10O4Se 225.10 OC(CC[Se]CCC(O)=O)=O 8023-25-4 3-[(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one C8H7N3O5 225.16O=N(=O)c1oc(cc1)C=NN2CCOC2=O 2440-22-4 2-(2`-HYDROXY-5`-METHYLPHENYL)-BENZOTRIAZOL C13H11N3O 225.25 Cc(ccc3O)cc3n2nc1ccccc1n2 60-11-7 4-(DIMETHYLAMINO)-AZOBENZOL C14H15N3 225.29CN(C)c2ccc(N=Nc1ccccc1)cc2 23031-25-6 terbutaline C12H19NO3 225.29CC(C)(C)NCC(O)c(cc1O)cc(O)c1

Page 101 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 26259-45-0 n-ethyl-6-methoxy-n'-(1-methylpropyl)-1,3,5-triazine-2,4-diamineC10H19N5O 225.29 CCC(C)Nc(nc1OC)nc(NCC)n1 1610-18-0 2-METHOXY-4,6-BIS-(ISOPROPYLAMINO)-1,3,5-TRIAZIN C10H19N5O 225.29CC(C)Nc(n1)nc(NC(C)C)nc1OC 2032-65-7 3,5-DIMETHYL-4-(METHYLTHIO)PHENOLMETHYLCARBAMATC11H15NO2S 225.31 CSc1c(C)cc(OC(=O)NC)cc1C 777-37-7 4-CHLOR-3-(TRIFLUORMETHYL)-NITROBENZOL C7H3ClF3NO2 225.55FC(F)(F)c1cc(ccc1Cl)N(=O)=O 121-17-5 4-CHLOR-3-NITROBENZOTRIFLUORID C7H3ClF3NO2 225.55FC(F)(F)c(ccc1Cl)cc1N(=O)=O 703-86-6 2,4,6-TRICHLOR-1,3,5-TRIMETHYLBORAZIN C3H9B3Cl3N3 225.92 CN1B(Cl)N(C)B(Cl)N(C)B1Cl 15606-95-8 ARSENSAEURE(H3ASO4)TRIETHYLESTER C6H15AsO4 226.10 CCO[As](OCC)(OCC)=O 93-97-0 BENZOESAEUREANHYDRID C14H10O3 226.23O=C(OC(=O)c2ccccc2)c1ccccc1 88381-75-3 2,2-DINITROTRICYCLO(3.3.1.1(3,7))DECAN C10H14N2O4 O=N(C3(C(CC2C1)CC1CC3C2)N(=O)=O)=O226.23 13048-33-4 2-PROPENSAEURE-1,6-HEXANDIYLESTER C12H18O4 226.27C=CC(OCCCCCCOC(=O)C=C)=O 76-74-4 pentobarbital C11H18N2O3 226.27CCCC(C)C1(CC)C(=O)NC(=O)NC1=O 93-96-9 1,1-(OXYDIETHYLIDENE)BISBENZENE C16H18O 226.31 CC(OC(C)c1ccccc1)c2ccccc2 4427-97-8 KOHLENSAEUREDICYCLOHEXYLESTER C13H22O3 226.31O=C(OC2CCCCC2)OC1CCCCC1 4437-20-1 2-(furan-2-ylmethyldisulfanylmethyl)furan C10H10O2S2 226.32 S(SCc1occc1)Cc2occc2 28588-75-2 2-methyl-3-(2-methylfuran-3-yl)disulfanylfuran C10H10O2S2 226.32 Cc2occc2SSc1ccoc1C 61295-41-8 3-(2-methylfuran-3-yl)sulfanylheptan-4-one C12H18O2S 226.34 CCCC(C(CC)Sc1ccoc1C)=O 2721-22-4 6-nonyloxan-2-one C14H26O2 226.36CCCCCCCCCC1OC(CCC1)=O 2345-28-0 2-PENTADECANON C15H30O 226.40 CCCCCCCCCCCCCC(C)=O 4390-04-9 2,2,4,4,6,8,8-HEPTAMETHYLNONAN C16H34 226.44CC(C)(C)CC(C)CC(C)(C)CC(C)(C)C 544-76-3 HEXADECAN C16H34 226.44 CCCCCCCCCCCCCCCC 55-63-0 1,2,3-PROPANTRIOLTRINITRAT C3H5N3O9 227.09O=N(OCC(CON(=O)=O)ON(=O)=O)=O 118-96-7 2-METHYL-1,3,5-TRINITROBENZOL C7H5N3O6 227.13Cc1c(cc(cc1N(=O)=O)N(=O)=O)N(=O)=O 3585-93-1 N-((4-METHOXYPHENYL)METHYLEN)BENZOLAMIN-N-OXIDC14H13NO2 227.26COc2ccc(cc2)C=N(c1ccccc1)=O 834-12-8 2-METHYLTHIO-4-ETHYLAMINO-6-ISOPROPYLAMINO-1,3,5-TRIAZINC9H17N5S 227.33 CCNc1nc(SC)nc(NC(C)C)n1 7287-19-6 2-METHYLTHIO-4,6-BIS-(ISOPROPYLAMINO)-1,3,5-TRIAZIN C9H17N5S 227.33 CC(C)Nc(n1)nc(NC(C)C)nc1S 638-58-4 MYRISTINSAEUREAMID C14H29NO 227.39 CCCCCCCCCCCCCC(=O)N 621-77-2 N,N-DIPENTYL-1-PENTANAMIN C15H33N 227.43 CCCCCN(CCCCC)CCCCC 2668-24-8 4,5,6-TRICHLORGUAIACOL C7H5Cl3O2 227.47 COc1cc(Cl)c(Cl)c(Cl)c1O 489-98-5 2,4,6-TRINITROBENZOLAMIN C6H4N4O6 228.12Nc1c(cc(cc1N(=O)=O)N(=O)=O)N(=O)=O 400-58-8 N-(N-(TRIFLUORACETYL)-AMINOACETYL)-AMINOESSIGSAEUREC6H7F3N2O4 228.13OC(=O)CNC(CNC(C(F)(F)F)=O)=O 131-57-7 (2-HYDROXY-4-METHOXYPHENYL)PHENYLMETHANON C14H12O3 228.24COc(ccc2C(=O)c1ccccc1)cc2O 78508-44-8 p-phenoxyphenylurea C13H12N2O2 228.25O=C(N)Nc(cc2)ccc2Oc1ccccc1 105-76-0 (2Z)-2-BUTENDISAEUREDIBUTYLESTER C12H20O4 228.29CCCCOC(=O)C=CC(OCCCC)=O 837-08-1 2-[1-(4-HYDROXYPHENYL)-1-METHYLETHYL]PHENOL C15H16O2 228.29CC(C)(c(cc2)ccc2O)c1ccccc1O 80-05-7 2,2-BIS-(4-HYDROXYPHENYL)-PROPAN C15H16O2 228.29CC(C)(c(cc2)ccc2O)c(cc1)ccc1O 217-59-4 TRIPHENYLEN C18H12 228.29c(ccc42)cc2c1ccccc1c3ccccc43 218-01-9 CHRYSEN C18H12 228.29c(ccc1c3c4)cc1ccc3c2ccccc2c4 56-55-3 1,2-BENZANTHRACEN C18H12 228.29c(ccc1cc3c2ccccc2c4)cc1cc3c4 92-24-0 NAPHTHACEN C18H12 228.29c(ccc1cc3cc2ccccc42)cc1cc3c4 195-19-7 BENZO(C)PHENANTHREN C18H12 228.29c(ccc1c3c2ccccc2c4)cc1ccc3c4 34014-18-1 tebuthiuron C9H16N4OS 228.32CC(C)(C)c1sc(nn1)N(C)C(=O)NC 94293-57-9 o-[2-[(1s)-4-methyl-2-oxocyclohexyl]propan-2-yl] ethanethioate C12H20O2S 228.35CC(CCC1C(C)(C)OC(C)=S)CC1=O 544-63-8 TETRADECANSAEURE C14H28O2 228.37 CCCCCCCCCCCCCC(O)=O 629-76-5 1-PENTADECANOL C15H32O 228.42 OCCCCCCCCCCCCCCC 19937-59-8 METOXURON C10H13ClN2O2 228.68 COc1ccc(cc1Cl)NC(=O)N(C)C 78508-46-0 3-methyl-4-bromophenylurea C8H9BrN2O 229.07 Brc1ccc(cc1C)NC(=O)N 88-89-1 2,4,6-TRINITROPHENOL C6H3N3O7 229.10Oc1c(cc(cc1N(=O)=O)N(=O)=O)N(=O)=O 225-11-6 BENZ(A)ACRIDIN C17H11N 229.28c(ccc2nc3c1ccccc1ccc3c4)cc42 225-51-4 benz(c)acridine C17H11N 229.28c(ccc2cc3c1ccccc1ccc3n4)cc42 7673-09-8 n2,n4,n6-trichloro-1,3,5-triazine-2,4,6-triamine C3H3Cl3N6 229.46 ClNc1nc(NCl)nc(NCl)n1 1912-26-1 trietazine C9H16ClN5 229.71 CCNc1nc(N(CC)CC)nc(Cl)n1 139-40-2 2-CHLOR-4,6-BIS-ISOPROPYLAMINO-1,3,5-TRIAZIN C9H16ClN5 229.71 CC(C)Nc(n1)nc(NC(C)C)nc1Cl 5915-41-3 TERBUTYLAZINE C9H16ClN5 229.71 CCNc1nc(NC(C)(C)C)nc(Cl)n1 688-74-4 BORSAEURE(H3BO3)TRIBUTYLESTER C12H27BO3 230.15 CCCCOB(OCCCC)OCCCC 3337-71-1 methylsulfanilylcarbamate C8H10N2O4S 230.24Nc1ccc(cc1)S(=O)(=O)NC(OC)=O 82-05-3 7H-BENZ(DE)ANTHRACEN-7-ON C17H10O 230.26O=C4c3c2c(ccc3)cccc2c1ccccc41 22204-53-1 (S)-2-(6-METHOXYNAPHTHALIN)-2-METHYLESSIGSAEURE C14H14O3 230.26COc2cc1ccc(C(C)C(O)=O)cc1cc2 693-23-2 1,12-DODECANDISAEURE C12H22O4 230.30OC(CCCCCCCCCCC(O)=O)=O 959-02-4 5,12-DIHYDROTETRACEN C18H14 230.31C4c3cc1ccccc1cc3Cc2ccccc42 92-94-4 1,4-DIPHENYLBENZOL C18H14 230.31 c(cc2)ccc2c3ccc(cc3)c1ccccc1 92-06-8 1,3-DIPHENYLBENZOL C18H14 230.31 c(cc1)ccc1c(ccc3)cc3c2ccccc2 2175-90-8 6,6-diphenylfulvene C18H14 230.31c(cc2)ccc2C(c3ccccc3)=c1cccc1

Page 102 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 84-15-1 1,2-DIPHENYLBENZOL C18H14 230.31 c(cc1)ccc1c3ccccc3c2ccccc2 87061-04-9 3-(5-methyl-2-propan-2-ylcyclohexyl)oxypropane-1,2-diol C13H26O3 230.35OCC(O)COC1CC(C)CCC1C(C)C 40915-96-6 TRIDECANPEROXOSAEURE C13H26O3 230.35 CCCCCCCCCCCCC(OO)=O 6911-51-9 2-thiophen-2-yldisulfanylthiophene C8H6S4 230.40 S(Sc2sccc2)c1sccc1 2550-40-5 DICYCLOHEXYLDISULFID C12H22S2 230.44 C(CC1)CCC1SSC2CCCCC2 3481-20-7 2,3,5,6-TETRACHLORBENZOLAMIN C6H3Cl4N 230.91 Clc1cc(Cl)c(Cl)c(N)c1Cl 634-83-3 2,3,4,5-TETRACHLORBENZOLAMIN C6H3Cl4N 230.91 Nc1cc(Cl)c(Cl)c(Cl)c1Cl 1929-82-4 2-CHLOR-6-TRICHLORMETHYLPYRIDIN C6H3Cl4N 230.91 ClC(Cl)(Cl)c(ccc1)nc1Cl 22401-53-2 5-nitro-2-acetoxy-2,5-dihydro-2-furancarboxylicac C8H9NO7 231.16COC(=O)C1(OC(C)=O)C=CC(O1)N(=O)=O 6626-64-8 n-methyl-2,3-5,6-dibenzazalene C17H13N 231.29 Cn4c2cc1ccccc1c2cc3ccccc43 4901-51-3 2,3,4,5-TETRACHLORPHENOL C6H2Cl4O 231.89 Oc1cc(Cl)c(Cl)c(Cl)c1Cl 935-95-5 2,3,5,6-TETRACHLORPHENOL C6H2Cl4O 231.89 Clc1cc(Cl)c(Cl)c(O)c1Cl 58-90-2 2,3,4,6-TETRACHLORPHENOL C6H2Cl4O 231.89 Clc1cc(Cl)c(Cl)c(Cl)c1O 355-80-6 1,1,5-TRIHYDROPERFLUOR-1-PENTANOL C5H4F8O 232.07OCC(F)(F)C(F)(F)C(F)(F)C(F)F 2164-17-2 FLUOMETURON C10H11F3N2O 232.20FC(F)(F)c1cc(ccc1)NC(=O)N(C)C 50-06-6 5-ETHYL-5-PHENYL-2,4,6(1H,3H,5H)-PYRIMIDINTRION C12H12N2O3 232.24CCC2(c1ccccc1)C(=O)NC(=O)NC2=O 1982-49-6 siduron C14H20N2O 232.32CC2CCCCC2NC(=O)Nc1ccccc1 19095-79-5 1-cycloheptyl-3-phenylurea C14H20N2O 232.32O=C(NC2CCCCCC2)Nc1ccccc1 79-78-7 (1e)-1-(2,6,6-trimethyl-1-cyclohex-2-enyl)hepta-1,6-dien-3-one C16H24O 232.36CC1(C)CCC=C(C)C1C=CC(CCC=C)=O 4067-16-7 3,6,9.12-TETRAAZATETRADECANE-1,14-DIAMINE C10H28N6 232.37 NCCNCCNCCNCCNCCN 18023-33-1 ETHENYLTRIS(1-METHYLETHOXY)SILAN C11H24O3Si 232.39CC(C)O[Si](OC(C)C)(OC(C)C)C=C 10220-20-9 piperidine,1,1'-dithiobis- C10H20N2S2 232.41 C(CC1)CCN1SSN2CCCCC2 6742-54-7 UNDECYLBENZOL C17H28 232.41 CCCCCCCCCCCc1ccccc1 85-19-8 (5-CHLOR-2-HYDROXYPHENYL)-PHENYLKETON C13H9ClO2 232.66 Clc(ccc2O)cc2C(=O)c1ccccc1 144-79-6 silane,chloromethyldiphenyl- C13H13ClSi 232.78 C[Si](Cl)(c2ccccc2)c1ccccc1 356-18-3 1,2-DICHLOR-1,2,3,3,4,4-HEXAFLUORCYCLOBUTAN C4Cl2F6 232.94 FC1(F)C(F)(Cl)C(F)(Cl)C1(F)F 330-54-1 DIURON C9H10Cl2N2O 233.10 Clc1ccc(cc1Cl)NC(=O)N(C)C 1132-39-4 DIPHENYLSELENID C12H10Se 233.17 [Se](c2ccccc2)c1ccccc1 1148-79-4 2,2',2''-terpyridine C15H11N3 233.27c(cn1)ccc1c(ccc3)nc3c2ccccn2 5972-07-6 3,6-BIS-(DIMETHYLAMINO)-PHTHALIMID C12H15N3O2 233.27CN(C)c2c1C(=O)NC(c1c(N(C)C)cc2)=O 18799-75-2 BIS-(TRIFLUOROMETHYL)-PHOSPHINODITHIOAT C2HF6PS2 234.12 FC(F)(F)SPSC(F)(F)F 78024-33-6 PROPANOICACID,2-(2-HYDROXY-1-OXOPROPOXY)-1-CARBOXYETHYLEC9H14O7 234.20OC(C)C(OC(C)C(OC(C)C(O)=O)=O)=O 17689-77-9 ethylsilanetrioltriacetate C8H14O6Si 234.28CC[Si](OC(C)=O)(OC(C)=O)OC(C)=O 219-25-0 phenanthro[2,1-b]thiophene C16H10S 234.32 c(ccc1c2ccc3s4)cc1ccc2c3cc4 205-43-6 benzo(b)naphtho(1,2-d)thiophene C16H10S 234.32 c(ccc1c3c2ccccc42)cc1ccc3s4 243-46-9 BENZO(B)NAPHTHO(2,3-D)THIOPHEN C16H10S 234.32 c(ccc1cc3s4)cc1cc3c2ccccc42 239-35-0 benzo(b)naphtho(2,1-d)thiophene C16H10S 234.32 c(ccc1c3s4)cc1ccc3c2ccccc42 25961-89-1 HEXYLTRIGLYKOL C12H26O4 234.33 OCCOCCOCCOCCCCCC 16225-26-6 3,5-DI-TERT.-BUTYLBENZOESAEURE C15H22O2 234.34CC(C)(C)c1cc(C(O)=O)cc(C(C)(C)C)c1 137-58-6 2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)ACETAMID C14H22N2O 234.34CCN(CC)CC(=O)Nc1c(C)cccc1C 2040-73-5 (18)-annulene C18H18 234.34 c1ccccccccccccccccc1 7343-06-8 3,4,5,6-TETRAMETHYLPHENANTHREN C18H18 234.34Cc3ccc(ccc2ccc1C)c(c3C)c2c1C 7396-38-5 2,4,5,7-TETRAMETHYLPHENANTHREN C18H18 234.34Cc(cc1C)cc(ccc2cc3C)c1c2c(C)c3 37170-96-0 9-ACETAMIDOANTHRACEN C16H13NO 235.28CC(=O)Nc3c1ccccc1cc2ccccc32 106-37-6 1,4-DIBROMBENZOL C6H4Br2 235.90 Brc1ccc(Br)cc1 108-36-1 1,3-DIBROMBENZOL C6H4Br2 235.90 Brc1cc(Br)ccc1 696-33-3 iodoxybenzene C6H5IO2 236.01 O=I(c1ccccc1)=O 434-64-0 PENTAFLUOR(TRIFLUORMETHYL)BENZOL C7F8 236.06FC(F)(F)c(c(F)c1F)c(F)c(F)c1F 68936-77-6 1,1,2-TRIFLUORO-1,2-DIPHENYLETHAN C14H11F3 236.23 FC(C(F)(F)c2ccccc2)c1ccccc1 298-46-4 5-H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE C15H12N2O 236.27O=C(N)n3c1ccccc1ccc2ccccc32 1085-12-7 heptyl 4-hydroxybenzoate C14H20O3 236.31CCCCCCCOC(=O)c(cc1)ccc1O 104-71-2 n,n'-dibenzylideneethylenediamine C16H16N2 236.31C(CN=Cc1ccccc1)N=Cc2ccccc2 59-46-1 4-AMINOBENZOESAEURE-2-(DIETHYLAMINO)ETHYLESTERC13H20N2O2 236.31CCN(CC)CCOC(=O)c(cc1)ccc1N 2530-83-8 SILANE,TRIMETHOXY[3-(OXIRANYLMETHOXY)-PROPYL] C9H20O5Si 236.34CO[Si](OC)(OC)CCCOCC1OC1 88-26-6 2,6-ditert-butyl-4-(hydroxymethyl)phenol C15H24O2 236.35OCc(cc1C(C)(C)C)cc(C(C)(C)C)c1O 6362-80-7 SEENOTEONMOLECULARWEIGHT C18H20 236.35CC(C)(CC(=C)c1ccccc1)c2ccccc2 2913-24-8 3,3-PARACYCLOPHAN C18H20 236.35C(Cc2ccc3cc2)Cc1ccc(CCC3)cc1 107-51-7 OCTAMETHYLTRISILOXAN C8H24O2Si3 236.53C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C 67-72-1 PERCHLORETHAN C2Cl6 236.74 ClC(Cl)(Cl)C(Cl)(Cl)Cl 1122-44-7 5-iodocytosine C4H4IN3O 237.00 Oc(ncc1I)nc1N 82-38-2 1-METHYLAMINOANTHRACHINON C15H11NO2 237.25CNc2cccc3c2C(=O)c1ccccc1C3=O 59-06-3 methyl 4-acetamido-2-ethoxybenzoate C12H15NO4 237.25CCOc1cc(ccc1C(OC)=O)NC(C)=O

Page 103 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 355-25-9 DECAFLUORBUTAN C4F10 238.03FC(F)(F)C(F)(F)C(F)(F)C(F)(F)F 67-20-9 1-(5-nitro-2-furfurylideneamino)hydantoin C8H6N4O5 238.16O=N(=O)c1oc(cc1)C=NN2CC(=O)NC2=O 1709-63-3 1,4,9,10-ANTHRACENTETRON C14H6O4 238.20O=C(c1ccccc1C3=O)C2=C3C(=O)C=CC2=O 3274-20-2 2-METHOXY-9,10-ANTHRACENDION C15H10O3 238.24COc(ccc2C3=O)cc2C(=O)c1ccccc31 82-39-3 1-METHOXY-9,10-ANTHRACENDION C15H10O3 238.24COc2cccc3c2C(=O)c1ccccc1C3=O 128-95-0 KRESOLAMIN C14H10N2O2 238.24Nc2ccc(N)c3c2C(=O)c1ccccc1C3=O 4552-64-1 3-buten-2-one,1,1,1-trifluoro-4-mercapto-4-(2-thi C8H5F3OS2 238.25 FC(F)(F)C(O)=CC(c1sccc1)=S 23103-98-2 pirimicarb C11H18N4O2 238.29CN(C)c(nc1C)nc(OC(=O)N(C)C)c1C 1889-67-4 2,3-DIMETHYL-2,3-DIPHENYLBUTAN C18H22 238.37CC(C)(C(C)(C)c2ccccc2)c1ccccc1 51526-06-8 1,1-(1,2-ETHANEDIYL)BIS(4-ETHYL-)BENZENE C18H22 238.37CCc2ccc(CCc(cc1)ccc1CC)cc2 541-91-3 3-methylcyclopentadecan-1-one C16H30O 238.41CC1CC(CCCCCCCCCCCC1)=O 2550-52-9 CYCLOHEXADECANON C16H30O 238.41O=C1CCCCCCCCCCCCCCC1 14814-09-6 1-PROPANETHIOL,3-(TRIETHOXYSILYL)- C9H22O3SSi 238.42 SCCC[Si](OCC)(OCC)OCC 637-87-6 4-CHLORIODBENZOL C6H4ClI 238.45 Clc1ccc(I)cc1 6765-39-5 1-HEPTADECEN C17H34 238.45 CCCCCCCCCCCCCCCC=C 295-97-6 CYCLOHEPTADECAN C17H34 238.45 C1CCCCCCCCCCCCCCCC1 5634-30-0 DODECYLCYCLOPENTAN C17H34 238.45 CCCCCCCCCCCCC1CCCC1 116-85-8 1-AMINO-4-HYDROXYANTHRACHINON C14H9NO3 239.23Oc2ccc(N)c3c2C(=O)c1ccccc1C3=O 85-34-7 2,3,6-TRICHLORBENZOLESSIGSAEURE C8H5Cl3O2 239.48 OC(=O)Cc(c(Cl)ccc1Cl)c1Cl 940-41-0 silane,trichloro(2-phenylethyl)- C8H9Cl3Si 239.60 Cl[Si](Cl)(Cl)CCc1ccccc1 618-71-3 3,5-dinitrobenzoicacidethylester C9H8N2O6 240.17CCOC(=O)c1cc(cc(c1)N(=O)=O)N(=O)=O 117-12-4 1,5-DIHYDROXY-9,10-ANTHRACENDION C14H8O4 240.21Oc1cccc(C(=O)c2c3cccc2O)c1C3=O 88-85-7 2-(1-METHYLPROPYL)-4,6-DINITROPHENOL C10H12N2O5 240.21CCC(C)c1cc(cc(c1O)N(=O)=O)N(=O)=O 81-64-1 1,4-DIHYDROXYANTHRACHINON C14H8O4 240.21Oc2ccc(O)c3c2C(=O)c1ccccc1C3=O 117-10-2 1,8-DIHYDROXY-9,10-ANTHRACENDION C14H8O4 240.21Oc1cccc(C3=O)c1C(=O)c2c3cccc2O 72-48-0 ALIZARIN C14H8O4 240.21Oc2ccc3c(C(=O)c1ccccc1C3=O)c2O 84-60-6 2,6-DIHYDROXY-9,10-ANTHRACENDION C14H8O4 240.21Oc(ccc1C(=O)c2cc(O)ccc32)cc1C3=O 25057-89-0 3-(1-METHYLETHYL)-1H-2,1,3-BENZOTHIADIAZIN-4(3H)-ON-2,2-DIOXIDC10H12N2O3S 240.28CC(C)N2C(c1ccccc1NS2(=O)=O)=O 21956-56-9 BENZENE,1,3-DIMETHOXY-5-(2-PHENYLETHENYL)-,(E)- C16H16O2 240.30COc2cc(C=Cc1ccccc1)cc(OC)c2 2195-65-69 (z)-1,3-dimethoxy-5-(2-phenylethenyl)-benzene C16H16O2 240.30COc2cc(C=Cc1ccccc1)cc(OC)c2 923-32-0 DL-CYSTIN C6H12N2O4S2 240.30NC(CSSCC(N)C(O)=O)C(O)=O 19219-01-3 TETRACYCLOPROPYLBUTANDINITRIL C16H20N2 N#CC(C2CC2)(C1CC1)C(C4CC4)(C3CC3)C#N240.34 780-69-8 TRIETHOXYPHENYLSILAN C12H20O3Si 240.37 CCO[Si](OCC)(OCC)c1ccccc1 32539-85-8 oxacyclopentadecan-2-one,15-methyl- C15H28O2 240.38CC1OC(CCCCCCCCCCCC1)=O 13349-10-5 TETRADECAHYDRO-4,5,12-METHENO-2,9,7-(1,2,3)PROPANTRIYLANTHRACENC18H24 C16C7C5C2C3C(C4C1C2(CC(C3)C4)CC(C5)C6)C7240.38 629-78-7 HEPTADECAN C17H36 240.47 CCCCCCCCCCCCCCCCC 2370-88-9 2,4,6,8-TETRAMETHYLCYCLOTETRASILOXAN C4H16O4Si4 240.51C[SiH]1O[SiH](C)O[SiH](C)O[SiH](C)O1 21725-46-2 2-((4-CHLOR-6-(ETHYLAMINO)-1,3,5-TRIAZIN-2-YL)AMINO)-2-METHYLPROPANNITRILC9H13ClN6 240.69CCNc1nc(NC(C)(C)C#N)nc(Cl)n1 38677-56-4 (2,2,2-TRINITROETHYL)BENZOL C8H7N3O6 241.16O=N(=O)C(Cc1ccccc1)(N(=O)=O)N(=O)=O 632-92-8 2,4-DIMETHYL-1,3,5-TRINITROBENZOL C8H7N3O6 241.16Cc1c(c(C)c(cc1N(=O)=O)N(=O)=O)N(=O)=O 886-50-0 TERBUTRYN C10H19N5S 241.36CCNc1nc(SC)nc(NC(C)(C)C)n1 7438-09-7 N-METHYLMYRISTINSAEUREAMID C15H31NO 241.41 CCCCCCCCCCCCCC(=O)NC 1918-02-1 4-amino-3,5,6-trichloropyridine-2-carboxylicacid0 C6H3Cl3N2O2 241.46 OC(=O)c(nc1Cl)c(Cl)c(N)c1Cl 1120-48-5 N-OCTYL-1-OCTANAMIN C16H35N 241.46 CCCCCCCCNCCCCCCCC 106-20-7 BIS-(2-ETHYLHEXYL)-AMIN C16H35N 241.46 CCCCC(CC)CNCC(CC)CCCC 10222-01-2 2,2-dibromo-2-cyanoacetamide C3H2Br2N2O 241.87 BrC(Br)(C#N)C(=O)N 960-71-4 TRIPHENYLBORAN C18H15B 242.12c(cc1)ccc1B(c3ccccc3)c2ccccc2 433-33-0 N-(N-(TRIFLUORACETYL)-GLYCYL)-GLYCIN-METHYLESTERC7H9F3N2O4 242.15COC(=O)CNC(CNC(C(F)(F)F)=O)=O 94-36-0 DIBENZOYLPEROXID C14H10O4 242.23O=C(OOC(=O)c2ccccc2)c1ccccc1 3155-16-6 ETHANDISAEUREDIPHENYLESTER C14H10O4 242.23O=C(Oc2ccccc2)C(Oc1ccccc1)=O 482-05-3 DIPHENSAEURE C14H10O4 242.23OC(=O)c1ccccc1c2ccccc2C(O)=O 730-40-5 4`-NITRO-4-AMINOAZOBENZOL C12H10N4O2 242.23Nc2ccc(N=Nc1ccc(cc1)N(=O)=O)cc2 124-10-7 TETRADECANSAEUREMETHYLESTER C15H30O2 242.40 CCCCCCCCCCCCCC(OC)=O 1002-84-2 PENTADECANSAEURE C15H30O2 242.40 CCCCCCCCCCCCCCC(O)=O 629-82-3 DIOCTYLETHER C16H34O 242.44 CCCCCCCCOCCCCCCCC 36653-82-4 1-HEXADECANOL C16H34O 242.44 OCCCCCCCCCCCCCCCC 606-35-9 2-METHOXY-1,3,5-TRINITROBENZOL C7H5N3O7 243.13COc1c(cc(cc1N(=O)=O)N(=O)=O)N(=O)=O 602-99-3 2,4,6-TRINITRO-1,3-KRESOL C7H5N3O7 243.13Oc1c(c(C)c(cc1N(=O)=O)N(=O)=O)N(=O)=O 28930-29-2 1,3-diamino-2,4,6-trinitrobenzene C6H5N5O6 243.13Nc1c(c(N)c(cc1N(=O)=O)N(=O)=O)N(=O)=O 92-55-7 2-(diacetoxymethyl)-5-nitrofuran C9H9NO7 243.17CC(OC(OC(C)=O)c1oc(cc1)N(=O)=O)=O 6926-05-2 (phenylmethyl)selenopropanoicacid C10H12O2Se 243.17 OC(CC[Se]Cc1ccccc1)=O 1435-60-5 4-NITRO-4`-HYDROXYAZOBENZOL C12H9N3O3 243.22Oc2ccc(N=Nc1ccc(cc1)N(=O)=O)cc2

Page 104 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 16112-55-3 2-propanol,1-phenoxy-3-(phenylamino)- C15H17NO2 243.30 OC(COc2ccccc2)CNc1ccccc1 2642-98-0 6-CHRYSENAMIN C18H13N 243.30Nc4c1ccccc1c3ccc2ccccc2c3c4 1912-25-0 ipazine C10H18ClN5 243.74CC(C)Nc(n1)nc(N(CC)CC)nc1Cl 718-64-9 hexafluoro-2-phenylisopropanol C9H6F6O 244.13FC(F)(F)C(O)(C(F)(F)F)c1ccccc1 1528-74-1 4,4`-DINITROBIPHENYL C12H8N2O4 244.20O=N(=O)c(cc1)ccc1c2ccc(cc2)N(=O)=O 131-53-3 (2-HYDROXY-4-METHOXYPHENYL)-(2-HYDROXYPHENYL)-KETONC14H12O4 244.24COc(ccc2C(=O)c1ccccc1O)cc2O 840-65-3 2,6-NAPHTHALINDICARBONSAEUREDIMETHYLESTER C14H12O4 244.24COC(=O)c(ccc1cc2C(OC)=O)cc1cc2 5104-49-4 FLURBIPROFEN C15H13FO2 244.26CC(C(O)=O)c(ccc2c1ccccc1)cc2F 10435-67-3 2-PHENYLINDENO-(2,1-B)-PYRAN C18H12O 244.29c(cc1)ccc1C4=CC=C3c2ccccc2C=C3O4 16212-06-9 (E)-[(2-PHENYLETHENYL)SULFONYL]-BENZOL C14H12O2S 244.31O=S(c2ccccc2)(=O)C=Cc1ccccc1 58-85-5 5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-6-yl)pentanoicC10H16N2O3S acid 244.31OC(CCCCC2C1NC(=O)NC1CS2)=O 821-38-5 TETRADECANDISAEURE C13H24O4 244.33OC(CCCCCCCCCCCC(O)=O)=O 519-73-3 TRIPHENYLMETHAN C19H16 244.33c(cc1)ccc1C(c3ccccc3)c2ccccc2 13171-00-1 1-(6-tert-butyl-1,1-dimethyl-2,3-dihydroinden-4-yl)ethanone C17H24O 244.37CC(C)(C)c(cc1c2CCC1(C)C)cc2C(C)=O 19816-73-0 TETRADECANPEROXOSAEURE C14H28O3 244.37 CCCCCCCCCCCCCC(OO)=O 706-79-6 1,2-DICHLOR-3,3,4,4,5,5-HEXAFLUORCYCLOPENTEN C5Cl2F6 244.95FC1(F)C(F)(F)C(Cl)=C(Cl)C1(F)F 994-65-0 TETRAPROPYLGERMAN C12H28Ge 244.99 CCC[Ge](CCC)(CCC)CCC 82-71-3 2,4,6-TRINITRO-1,3-BENZOLDIOL C6H3N3O8 245.10Oc1c(c(O)c(cc1N(=O)=O)N(=O)=O)N(=O)=O 3434-54-6 5,7(4h,6h)-[1,2,5]selenadiazolo[3,4-d]pyrimidine C6H6N4O2Se 245.10O=C2N(c1n[se]nc1C(=O)N2C)C 603-34-9 N,N-DIPHENYLBENZOLAMIN C18H15N 245.32c(cc2)ccc2N(c3ccccc3)c1ccccc1 728-88-1 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone C16H23NO 245.36CC(CN1CCCCC1)C(=O)c(cc2)ccc2C 118-75-2 2,3,5,6-TETRACHLOR-2,5-CYCLOHEXADIEN-1,4-DION C6Cl4O2 245.88ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O 131-55-5 2,2`,4,4`-TETRAHYDROXYBENZOPHENON C13H10O5 246.22Oc(ccc1C(=O)c2ccc(O)cc2O)cc1O 3119-88-8 2`-FLUOR-2-HYDROXY-4-METHOXYBENZOPHENON C14H11FO3 246.24COc(ccc2C(=O)c1ccccc1F)cc2O 131-17-9 1,2-BENZOLDICARBONSAEUREDI-2-PROPENYLESTER C14H14O4 246.26C=CCOC(=O)c1ccccc1C(OCC=C)=O 599-66-6 DI-P-TOLYLSULFON C14H14O2S 246.33Cc1ccc(cc1)S(c(cc2)ccc2C)(=O)=O 620-32-6 DIBENZYLSULFON C14H14O2S 246.33O=S(Cc2ccccc2)(Cc1ccccc1)=O 58797-59-4 1-tert-butoxy-2-[2-(tert-butoxy)propoxy]propane C14H30O3 246.39CC(OCC(C)OC(C)(C)C)COC(C)(C)C 150-60-7 BIS(PHENYLMETHYL)DISULFID C14H14S2 246.39 S(SCc1ccccc1)Cc2ccccc2 4032-80-8 BIS(2-METHYLPHENYL)DISULFID C14H14S2 246.39 Cc2ccccc2SSc1ccccc1C 604-88-6 HEXAETHYLBENZOL C18H30 246.43CCc1c(CC)c(CC)c(CC)c(CC)c1CC 123-01-3 DODECYLBENZOL C18H30 246.43 CCCCCCCCCCCCc1ccccc1 635-11-0 1,2,4,5-TETRAKIS(1-METHYLETHYL)BENZOL C18H30 246.43CC(C)c1cc(C(C)C)c(C(C)C)cc1C(C)C 1460-02-2 1,3,5-TRIS(1,1-DIMETHYLETHYL)BENZOL C18H30 246.43CC(C)(C)c1cc(C(C)(C)C)cc(C(C)(C)C)c1 994-49-0 HEXAETHYLDISILOXAN C12H30OSi2 246.54CC[Si](CC)(CC)O[Si](CC)(CC)CC 314-42-1 isocil C8H11BrN2O2 247.09CC(C)n(c(=O)[nH]c1C)c(=O)c1Br 776-74-9 bromodiphenylmethane C13H11Br 247.13 BrC(c2ccccc2)c1ccccc1 57-42-1 1-METHYL-4-PHENYL-4-PIPERIDINCARBONSAEUREETHYLESTERC15H21NO2 247.33CCOC(=O)C2(CCN(C)CC2)c1ccccc1 5283-66-9 N-OCTYL-TRICHLOROSILANE C8H17Cl3Si 247.67 CCCCCCCC[Si](Cl)(Cl)Cl 87-87-6 2,3,5,6-TETRACHLOR-1,4-BENZOLDIOL C6H2Cl4O2 247.89 Oc1c(Cl)c(Cl)c(O)c(Cl)c1Cl 619-58-9 4-JODBENZOESAEURE C7H5IO2 248.02 OC(=O)c(cc1)ccc1I 88-67-5 2-IODBENZOESAEURE C7H5IO2 248.02 OC(=O)c1ccccc1I 2897-60-1 [3-(glycidyloxy)propyl]methyldiethoxysilane C11H24O4Si 248.39CCO[Si](C)(OCC)CCCOCC1OC1 645-00-1 3-IODNITROBENZOL C6H4INO2 249.01 Ic1cc(ccc1)N(=O)=O 330-55-2 LINURON C9H10Cl2N2O2 249.10CON(C)C(=O)Nc(ccc1Cl)cc1Cl 143-15-7 1-DODECYLBROMID C12H25Br 249.23 CCCCCCCCCCCCBr 225-83-2 12h-benzo[c]phenothiazine C16H11NS 249.33c(ccc1c3[nH]c2ccccc42)cc1ccc3s4 226-06-2 7h-benzo[c]phenothiazine C16H11NS 249.33c(ccc1c3sc2ccccc42)cc1ccc3[nH]4 376-77-2 DECAFLUORCYCLOPENTAN C5F10 250.04FC1(F)C(F)(F)C(F)(F)C(F)(F)C1(F)F 101-68-8 4,4`-DIISOCYANATODIPHENYLMETHAN C15H10N2O2 250.25O=C=Nc(cc1)ccc1Cc2ccc(cc2)N=C=O 131-16-8 1,2-BENZOLDICARBONSAEUREDIPROPYLESTER C14H18O4 250.29CCCOC(=O)c1ccccc1C(OCCC)=O 726-78-3 n-methylcyclobarbital C13H18N2O3 CCC2(C1=CCCCC1)C(=O)N(C)C(=O)NC2=O250.29 1559-34-8 BUTYLTETRAGLYKOL C12H26O5 250.33 OCCOCCOCCOCCOCCCC 608-93-5 PENTACHLORBENZOL C6HCl5 250.34 Clc1cc(Cl)c(Cl)c(Cl)c1Cl 564-20-5 3a,6,6,9a-tetramethyl-1,4,5,5a,7,8,9,9b-octahydronaphtho[8,7-d]furan-2-oneC16H26O2 250.38CC2(C)CCCC3(C)C1CC(OC1(C)CCC32)=O 542-46-1 (z)-9-cycloheptadecen-1-one C17H30O 250.42O=C1CCCCCCCC=CCCCCCCC1 10294-33-4 TRIBROMBORAN BBr3 250.52 BrB(Br)Br 23560-59-0 heptenophos0 C9H12ClO4P 250.62COP(OC)(OC2=C(Cl)C1C=CCC21)=O 445-66-9 2,6-dinitro-4-trifluoromethylbenzeneamine C7H4F3N3O4 251.12FC(F)(F)c(cc1N(=O)=O)cc(c1N)N(=O)=O 615-58-7 2,4-DIBROMPHENOL C6H4Br2O 251.90 Oc1ccc(Br)cc1Br 138495-42-8 1,1,1,2,3,4,4,5,5,5-DECAFLUOROPENTAN C5H2F10 252.05FC(F)(F)C(F)C(F)C(F)(F)C(F)(F)F 2459-10-1 TRIMELLITSAEURETRIMETHYLESTER C12H12O6 252.22COC(=O)c(ccc1C(OC)=O)cc1C(OC)=O

Page 105 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 95266-40-3 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylateC13H16O5 CCOC(=O)C(CC2=O)CC(=O)C2=C(O)C1CC1252.26 57-41-0 5,5-DIPHENYL-2,4-IMIDAZOLIDINDION C15H12N2O2 252.27O=C3NC(=O)NC3(c2ccccc2)c1ccccc1 198-55-0 PERYLEN C20H12 252.31c(cc1cccc5c1c2c4c3c5cccc3ccc4)c2 192-97-2 BENZO(E)PYREN C20H12 252.31c(ccc51)cc1c(cccc2c4)c2c3c5cccc3c4 50-32-8 3,4-BENZPYREN C20H12 252.31c(ccc1c3ccc(cccc2cc4)c2c3c4c5)cc51 205-99-2 BENZ(E)ACEPHENANTHRYLEN C20H12 252.31c(ccc1c4c3c5c2ccccc2c3ccc4)cc1c5 207-08-9 BENZO(K)FLUORANTHEN C20H12 252.31c(ccc1c5)cc1cc2c5c4c3c2cccc3ccc4 51481-61-9 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidineC10H16N6S 252.34Cc1[nH]cnc1CSCCNC(NC)=NC#N 28645-51-4 1-oxacycloheptadec-10-en-2-one C16H28O2 252.39O=C1CCCCCCCC=CCCCCCCO1 3661-77-6 CYCLOHEPTADECANON C17H32O 252.44O=C1CCCCCCCCCCCCCCCC1 112-88-9 1-OCTADECEN C18H36 252.48 CCCCCCCCCCCCCCCCC=C 6006-34-4 TRIDECYLCYCLOPENTAN C18H36 252.48CCCCCCCCCCCCCC1CCCC1 75-25-2 TRIBROMMETHAN CHBr3 252.73 BrC(Br)Br 38964-22-6 2,8-DICHLORDIBENZO(B,E)(1,4)DIOXIN C12H6Cl2O2 253.08Clc(ccc32)cc2Oc1cc(Cl)ccc1O3 33857-26-0 2,7-DICHLORDIBENZO(B,E)(1,4)DIOXIN C12H6Cl2O2 253.08Clc(ccc1Oc2cc(Cl)ccc32)cc1O3 29446-15-9 2,3-DICHLORDIBENZO-(B,E)(1,4)-DIOXIN C12H6Cl2O2 253.08 Clc3cc2Oc1ccccc1Oc2cc3Cl 91-94-1 3,3`-DICHLORBENZIDIN C12H10Cl2N2 253.13 Nc2ccc(cc2Cl)c(ccc1N)cc1Cl 80-10-4 DICHLORDIPHENYLSILAN C12H10Cl2Si 253.20 Cl[Si](Cl)(c2ccccc2)c1ccccc1 82-34-8 MONONITROANTHRACHINON C14H7NO4 253.21O=C3c2cccc(c2C(=O)c1ccccc31)N(=O)=O 723-46-6 4-AMINO-N-(5-METHYL-3-ISOXAZOLYL)BENZENESULFONAMC10H11N3O3S 253.28Nc2ccc(cc2)S(=O)(=O)Nc(no1)cc1C 7553-56-2 IOD I2 253.81 II 612-55-5 2-JODNAPHTHALIN C10H7I 254.07 Ic2cc1ccccc1cc2 89-05-4 PYROMELLITHSAEURE C10H6O8 254.15OC(=O)c1cc(C(O)=O)c(C(O)=O)cc1C(O)=O 425-32-1 1,1,2,2-TETRAFLUORO-1,2-DIPHENYLETHAN C14H10F4 254.22FC(F)(C(F)(F)c2ccccc2)c1ccccc1 959-26-2 BIS-(2-HYDROXYETHYL)-TEREPHTHALAT C12H14O6 254.24OCCOC(=O)c1ccc(C(OCCO)=O)cc1 723-47-7 4-amino-n-(5-methyl-1,2,4-oxadiazol-3-yl)benzenesulfonamide C9H10N4O3S 254.27Nc2ccc(cc2)S(=O)(=O)Nc(no1)nc1C 22071-15-4 ALPHA-(3-BENZOYLPHENYL)-PROPIONSAEURE C16H14O3 254.28CC(C(O)=O)c2cc(ccc2)C(=O)c1ccccc1 36330-85-5 FENBUFEN C16H14O3 254.28OC(CCC(=O)c2ccc(cc2)c1ccccc1)=O 477-75-8 TRIPTYCEN C20H14 254.33c(ccc1C4c3ccccc3C5c2c4cccc2)cc51 602-55-1 9-PHENYLANTHRACEN C20H14 254.33c(cc1)ccc1c4c2ccccc2cc3ccccc43 28588-73-0 3-(2,5-dimethylfuran-3-yl)disulfanyl-2,5-dimethylfuran C12H14O2S2 254.37 Cc(oc1C)cc1SSc2cc(C)oc2C 61295-51-0 2,6-dimethyl-3-(2-methylfuran-3-yl)sulfanylheptan-4-one C14H22O2S 254.39CC(C)CC(C(C(C)C)Sc1ccoc1C)=O 61295-50-9 4-(2-methylfuran-3-yl)sulfanylnonan-5-one C14H22O2S 254.39CCCCC(C(CCC)Sc1ccoc1C)=O 26438-26-6 NAPHTHALENE,1-NONYL- C19H26 254.41 CCCCCCCCCc2c1ccccc1ccc2 62850-21-9 2,2,5,5-TETRAMETHYL-3,4-DI-TERT.-BUTYLHEXAN C18H38 254.50CC(C)(C)C(C(C)(C)C)C(C(C)(C)C)C(C)(C)C 593-45-3 OCTADECAN C18H38 254.50 CCCCCCCCCCCCCCCCCC 602-96-0 1,3,5-TRIMETHYL-2,4,6-TRINITROBENZOL C9H9N3O6 Cc1c(c(C)c(c(C)c1N(=O)=O)N(=O)=O)N(=O)=O255.19 158269-46-6 4-amino-n-(1,3-thiazol-2-yl)benzenesulfonamide C9H9N3O2S2 255.32Nc1ccc(cc1)S(=O)(=O)Nc2sccn2 629-54-9 HEXADECANAMID C16H33NO 255.44CCCCCCCCCCCCCCCC(=O)N 93-76-5 (2,4,5-TRICHLORPHENOXY)ESSIGSAEURE C8H5Cl3O3 255.48 OC(COc(cc1Cl)c(Cl)cc1Cl)=O 119-91-5 2,2-BIQUINOLINYL C18H12N2 256.30c(ccc2nc4c3nc1ccccc1cc3)cc2cc4 3697-27-6 5,6-DIMETHYLCHRYSEN C20H16 256.34Cc4c2ccccc2c3ccc1ccccc1c3c4C 58-72-0 TRIPHENYLETHEN C20H16 256.34c(cc1)ccc1C=C(c3ccccc3)c2ccccc2 57-97-6 7,12-DIMETHYL-1,2-BENZANTHRACEN C20H16 256.34Cc4c3ccc2ccccc2c3c(C)c1ccccc41 56-56-4 9,10-dimethyl-1,2-benzanthracene C20H16 256.34Cc4c3ccc2ccccc2c3c(C)c1ccccc41 316-51-8 3,9-DIMETHYLBENZ[A]ANTHRACEN C20H16 256.34Cc(ccc1cc3c2ccc(C)cc2c4)cc1cc3c4 313-74-6 1,12-DIMETHYLBENZ(A)ANTHRACEN C20H16 256.34Cc2cccc(ccc3cc1ccccc41)c2c3c4C 19044-88-3 3,5-dinitro-n',n'-dipropylsulfanilamide C12H20N2O2S 256.37CCCN(CCC)c1ccc(cc1)S(=O)(=O)N 57-10-3 HEXADECANSAEURE C16H32O2 256.43CCCCCCCCCCCCCCCC(O)=O 55335-06-3 2-(3,5,6-trichloropyridin-2-yl)oxyacetic acid C7H4Cl3NO3 256.47 OC(COc(nc1Cl)c(Cl)cc1Cl)=O 1454-85-9 1-HEPTADECANOL C17H36O 256.47 OCCCCCCCCCCCCCCCCC 4732-14-3 2,4,6-TRINITROPHENETOL C8H7N3O7 257.16CCOc1c(cc(cc1N(=O)=O)N(=O)=O)N(=O)=O 43169-97-7 p-methylbenzylselenopropionicacid C11H14O2Se 257.19 OC(CC[Se]Cc(cc1)ccc1C)=O 37680-65-2 2,2`,5-TRICHLORBIPHENYL C12H7Cl3 257.54 Clc(ccc2Cl)cc2c1ccccc1Cl 37680-66-3 2,2`,4-TRICHLORBIPHENYL C12H7Cl3 257.54 Clc(ccc2c1ccccc1Cl)cc2Cl 7012-37-5 2,4,4`-TRICHLORBIPHENYL C12H7Cl3 257.54 Clc1ccc(cc1)c2ccc(Cl)cc2Cl 38444-86-9 2`,3,4-TRICHLORBIPHENYL C12H7Cl3 257.54 Clc2ccc(cc2Cl)c1ccccc1Cl 10380-08-2 triphosphoricacidc H5O10P3 257.96OP(O)(OP(O)(OP(O)(O)=O)=O)=O 3058-38-6 2,4,6-TRINITRO-1,3,5-BENZOLTRIAMIN C6H6N6O6 Nc1c(c(N)c(c(N)c1N(=O)=O)N(=O)=O)N(=O)=O258.15 962-16-3 BENZOYLPHENOXYCARBONYLPEROXID C14H10O5 258.23O=C(OOC(=O)c1ccccc1)Oc2ccccc2 1562-94-3 4,4`-AZOXYANISOL C14H14N2O3 258.27COc1ccc(cc1)N=N(c(cc2)ccc2OC)=O 2498-66-0 benz(a)anthracene-7,12-dione C18H10O2 258.27O=C4c3ccc2ccccc2c3C(=O)c1ccccc41

Page 106 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 1090-13-7 5,12-naphthacenedione C18H10O2 258.27O=C4c3cc2ccccc2cc3C(=O)c1ccccc41 54897-33-5 (Z)1-METHYL-4-[(2-PHENYLETHENYL)SULFONYL]-BENZOL C15H14O2S 258.34Cc2ccc(cc2)S(=O)(=O)C=Cc1ccccc1 16212-08-1 (E)1-METHYL-4-[(2-PHENYLETHENYL)SULFONYL]-BENZOL C15H14O2S 258.34Cc2ccc(cc2)S(=O)(=O)C=Cc1ccccc1 1520-42-9 1,1,2-TRIPHENYLETHAN C20H18 258.36C(C(c2ccccc2)c1ccccc1)c3ccccc3 2690-08-6 DIOCTYLSULFID C16H34S 258.51 CCCCCCCCSCCCCCCCC 3060-89-7 METOBROMURON C9H11BrN2O2 259.10 CON(C)C(=O)Nc(cc1)ccc1Br 961-68-2 2,4-DINITRODIPHENYLAMIN C12H9N3O4 259.22O=N(=O)c(ccc2Nc1ccccc1)cc2N(=O)=O 1821-27-8 BENZENAMINE,4-NITRO-N-(4-NITROPHENYL)- C12H9N3O4 259.22O=N(=O)c(cc1)ccc1Nc2ccc(cc2)N(=O)=O 525-66-6 1-((1-METHYLETHYL)AMINO)-3-(1-NAPHTHALINYLOXY)-2-PROPANOLC16H21NO2 259.34CC(C)NCC(O)COc2c1ccccc1ccc2 124-73-2 1,2-DIBROM-1,1,2,2-TETRAFLUORETHAN C2Br2F4 259.82 FC(F)(Br)C(F)(F)Br 139-45-7 TRIPROPYLGLYCERINESTER C12H20O6 260.28CCC(OCC(COC(CC)=O)OC(CC)=O)=O 76-84-6 ALPHA,ALPHA-DIPHENYLBENZOLMETHANOL C19H16O 260.33OC(c3ccccc3)(c2ccccc2)c1ccccc1 74-31-7 1,4-DI-(PHENYLAMINO)-BENZOL C18H16N2 260.33N(c1ccccc1)c(cc3)ccc3Nc2ccccc2 298-02-2 O,O-DIETHYL-S-((ETHYLTHIO)-METHYL)-DITHIOPHOSPHATC7H17O2PS3 260.38 CCSCSP(OCC)(OCC)=S 123-02-4 TRIDECYLBENZOL C19H32 260.46 CCCCCCCCCCCCCc1ccccc1 87-68-3 1,1,2,3,4,4-HEXACHLOR-1,3-BUTADIEN C4Cl6 260.76 ClC(Cl)=C(Cl)C(Cl)=C(Cl)Cl 879-39-0 2,3,4,5-tetrachloronitrobenzene C6HCl4NO2 260.89Clc1cc(c(Cl)c(Cl)c1Cl)N(=O)=O 117-18-0 2,3,5,6-TETRACHLORNITROBENZOL C6HCl4NO2 260.89Clc1cc(Cl)c(Cl)c(c1Cl)N(=O)=O 7159-34-4 pyroxychlor C7H5Cl4NO 260.93 COc1cc(C(Cl)(Cl)Cl)cc(Cl)n1 20354-26-1 2-(3,4-dichlorophenyl)-4-methyl-1,2,4-oxadiazolidine-3,5-dione C9H6Cl2N2O3 261.06Clc2ccc(cc2Cl)n(oc1=O)c(=O)n1C 314-40-9 bromacil C9H13BrN2O2 261.12CCC(C)n(c(=O)[nH]c1C)c(=O)c1Br 57239-17-5 p-fluorobenzylselenopropionicacid C10H11FO2Se 261.16 OC(CC[Se]Cc(cc1)ccc1F)=O 57239-16-4 m-fluorobenzylselenopropionicacid C10H11FO2Se 261.16 OC(CC[Se]Cc(ccc1)cc1F)=O 7351-61-3 2-PROPENOICACID,2-METHYL-,3-(TRICHLOROSILYL)PROPYLESTERC7H11Cl3O2Si 261.61Cl[Si](Cl)(Cl)CCCOC(=O)C(C)=C 355-74-8 2,2,3,3,4,4,5,5-OCTAFLUOR-1,6-HEXANEDIOL C6H6F8O2 262.10OCC(F)(F)C(F)(F)C(F)(F)C(F)(F)CO 482-89-3 2-(1,3-DIHYDRO-3-OXO-2H-INDOL-2-YLIDEN)-1,2-DIHYDRO-3H-INDOL-3-ONC16H10N2O2 262.26O=C3c1ccccc1NC3=C4Nc2ccccc2C4=O 603-35-0 TRIPHENYLPHOSPHIN C18H15P 262.29c(cc1)ccc1P(c3ccccc3)c2ccccc2 732-26-3 2,4,6-TRIS(1,1-DIMETHYLETHYL)PHENOL C18H30O 262.43CC(C)(C)c(cc1C(C)(C)C)cc(C(C)(C)C)c1O 1610-24-8 TRICYCLOHEXYLMETHAN C19H34 262.48C(CC1)CCC1C(C3CCCCC3)C2CCCCC2 765-09-3 1-TRIDECYLBROMID C13H27Br 263.26 CCCCCCCCCCCCCBr 72-69-5 3-(10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDEN)-N-METHYL-1-PROPANAMINC19H21N 263.38CNCCC=C3c1ccccc1CCc2ccccc32 119-30-2 5-iodo-2-hydroxybenzoicacid C7H5IO3 264.02 OC(=O)c1cc(I)ccc1O 723-57-9 3-methyl-6-trifluoromethyl-1,2,4-benzothiadiazine-1,1-dioxide C9H7F3N2O2S 264.23FC(F)(F)c(ccc21)cc1N=C(C)NS2(=O)=O 562-90-3 silicontetraacetate C8H12O8Si 264.26CC(O[Si](OC(C)=O)(OC(C)=O)OC(C)=O)=O 20666-86-8 BENZOYL(CYCLOHEXYLOXY)CARBONYLPEROXID C14H16O5 264.28O=C(OC2CCCCC2)OOC(=O)c1ccccc1 17455-13-9 18-KRONE-6-KRONENETHER C12H24O6 264.32C1OCCOCCOCCOCCOCCOC1 682-01-9 TETRAPROPOXYSILAN C12H28O4Si 264.44CCCO[Si](OCCC)(OCCC)OCCC 7000-79-5 1,3,5,7-TETRAMETHYL-2,4,6,8-TETRATHIATRICYCLO(3. C10H16S4 264.50CC1(S2)SC3(C)SC(C)(C1)SC2(C)C3 712-48-1 DIPHENYLARSENCHLORID C12H10AsCl 264.58 Cl[As](c2ccccc2)c1ccccc1 129618-40-2 viramunebi-rg-587 C16H15N3O 265.31Cc3ccnc4c3[nH]c(=O)c2ccccc2n4C1CC1 527-20-8 2,3,4,5,6-PENTACHLORBENZOLAMIN C6H2Cl5N 265.35 Nc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl 1897-32-1 chlorthalonil C8Cl4N2 265.91Clc1c(Cl)c(C#N)c(Cl)c(C#N)c1Cl 126-73-8 PHOSPHORSAEURETRIBUTYLESTER C12H27O4P 266.32CCCCOP(OCCCC)(OCCCC)=O 1191-87-3 2,5,8,11,14,17-HEXAOXAOCTADECAN C12H26O6 266.33 COCCOCCOCCOCCOCCOC 528-43-8 2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol C18H18O2 266.34C=CCc(ccc1O)cc1c2cc(CC=C)ccc2O 87-86-5 PENTACHLORPHENOL C6HCl5O 266.34 Oc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl 29122-68-7 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-benzeneacetamideC14H22N2O3 266.34CC(C)NCC(O)COc1ccc(CC(=O)N)cc1 207-83-0 1,2,5,6-dibenzofluorene C21H14 266.34C(c51)c4c2ccccc2ccc4c1cc3ccccc3c5 50-47-5 desipramine C18H22N2 266.38CNCCCN3c1ccccc1CCc2ccccc32 41096-46-2 ethyl-3,7,11-trimethyldodeca-2,4-dienoate C17H30O2 266.42CC(C)CCCC(C)CC=CC(C)=CC(OCC)=O 6907-37-5 CYCLOOCTADECANON C18H34O 266.46O=C1CCCCCCCCCCCCCCCCC1 18435-45-5 1-NONADECEN C19H38 266.51CCCCCCCCCCCCCCCCCC=C 1795-22-8 TETRADECYLCYCLOPENTAN C19H38 266.51CCCCCCCCCCCCCCC1CCCC1 239-64-5 13h-dibenzo(a,i)carbazole C20H13N 267.33c(ccc41)cc1ccc3c4[nH]c5c3ccc2ccccc52 194-59-2 7h-dibenzo[c,g]carbazole C20H13N 267.33c(ccc1c4c3c2ccccc2c5)cc1ccc4[nH]c3c5 51466-74-1 1-phenoxysilatrane C12H17NO4Si 267.35C(N3CCO[Si]2(OCC3)Oc1ccccc1)CO2 37350-58-6 metoprolol C15H25NO3 267.37COCCc(cc1)ccc1OCC(O)CNC(C)C 75-11-6 DIIODMETHAN CH2I2 267.84 ICI 83-66-9 1-METHYL-4-TERT.-BUTYL-3-METHOXY-2,6-DINITROBENZOLC12H16N2O5 COc1c(c(C)c(cc1C(C)(C)C)N(=O)=O)N(=O)=O268.27 14098-44-3 2,3,5,6,8,9,11,12-OCTAHYDRO-1,4,7,10,13-BENZOPENTAOXACYCLOPENTADECINC14H20O5 268.31O2CCOCCOc1ccccc1OCCOCC2 56-53-1 (e)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol C18H20O2 268.35CCC(c(cc2)ccc2O)=C(CC)c(cc1)ccc1O 56-49-5 3-METHYLCHOLANTHREN C21H16 268.35Cc3c1CCc(c1c5cc3)c4ccc2ccccc2c4c5

Page 107 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 37014-01-0 TETRAHYDRO-2,6-DIPHENYL-4H-THIOPYRAN-4-ON C17H16OS 268.38O=C(CC3c2ccccc2)CC(S3)c1ccccc1 16212-85-4 3,6-DIPHENYL-1,2-DITHIIN C16H12S2 268.40S=C(c1ccccc1)C=CC(c2ccccc2)=S 1120-25-8 (9Z)-9-HEXADECENSAEUREMETHYLESTER C17H32O2 268.44CCCCCCC=CCCCCCCCC(OC)=O 26438-27-7 1-DECYLNAPHTHALIN C20H28 268.44CCCCCCCCCCc2c1ccccc1ccc2 143-28-2 (9Z)-9-OCTADECEN-1-OL C18H36O 268.48OCCCCCCCCC=CCCCCCCCC 629-92-5 NONADECAN C19H40 268.52CCCCCCCCCCCCCCCCCCC 2832-40-8 N-(4-((2-HYDROXY-5-METHYLPHENYL)AZO)PHENYL)ACETAMIDC15H15N3O2 269.30Cc(ccc2O)cc2N=Nc1ccc(cc1)NC(C)=O 737-89-3 di-naphthalen-1-yl-amine C20H15N 269.34N(c4c2ccccc2ccc4)c3c1ccccc1ccc3 7388-58-1 N-METHYLHEXADECANAMID C17H35NO 269.47CCCCCCCCCCCCCCCC(=O)NC 6294-34-4 PHOSPHONICACID,(2-CHLOROETHYL)-,BIS(2-CHLOROETHYL)ESTERC6H12Cl3O3P 269.49 ClCCOP(CCCl)(OCCCl)=O 93-72-1 FENOPROP_(2,4,5-T) C9H7Cl3O3 269.51CC(C(O)=O)Oc(cc1Cl)c(Cl)cc1Cl 124-30-1 1-OCTADECANAMIN C18H39N 269.51NCCCCCCCCCCCCCCCCCC 15972-60-8 2-CHLOR-N-(2,6-DIETHYLPHENYL)-N-(METHOXYMETHYL)ACETAMIDC14H20ClNO2 269.77COCN(c1c(CC)cccc1CC)C(CCl)=O 3837-55-6 3-NITRO-4`-(N,N-DIMETHYLAMINO)-AZOBENZOL C14H14N4O2 270.29CN(C)c1ccc(N=Nc2cc(ccc2)N(=O)=O)cc1 2491-74-9 4-NITRO-4`-(N,N-DIMETHYLAMINO)-AZOBENZOL C14H14N4O2 270.29CN(C)c1ccc(N=Nc2ccc(cc2)N(=O)=O)cc1 87-18-3 p-tert-butylphenylsalicylate C17H18O3 270.32CC(C)(C)c2ccc(OC(=O)c1ccccc1O)cc2 5471-63-6 1,3diphenylisobenzofuran C20H14O 270.33c(cc1)ccc1c(o4)c3ccccc3c4c2ccccc2 41047-48-7 d,l-1,2-dimethyl-1,2-diphenylethyleneglycoldimethylether C18H22O2 270.37COC(C)(C(C)(OC)c2ccccc2)c1ccccc1 80-43-3 DICUMYLPEROXID C18H22O2 270.37CC(C)(OOC(C)(C)c1ccccc1)c2ccccc2 506-12-7 HEPTADECANSAEURE C17H34O2 270.45CCCCCCCCCCCCCCCCC(O)=O 112-39-0 HEXADECANSAEUREMETHYLESTER C17H34O2 270.45CCCCCCCCCCCCCCCC(OC)=O 110-27-0 TETRADECANSAEURE-1-METHYLETHYLESTER C17H34O2 270.45CCCCCCCCCCCCCC(OC(C)C)=O 26902-55-6 HEXACYCLOPROPYLETHAN C20H30 C1CC1C(C3CC3)(C2CC2)C(C6CC6)(C5CC5)C4CC4270.45 112-92-5 1-OCTADECANOL C18H38O 270.50OCCCCCCCCCCCCCCCCCC 2456-27-1 DINONYLETHER C18H38O 270.50CCCCCCCCCOCCCCCCCCC 7789-60-8 TRIBROMPHOSPHIN Br3P 270.69 BrP(Br)Br 13207-63-1 5-IOD-8-CHINOLINOL C9H6INO 271.06 Oc2c1ncccc1c(I)cc2 78508-43-7 3,5-dimethyl-4-bromophenyl-1,1-dimethylurea C11H15BrN2O 271.15Brc1c(C)cc(cc1C)NC(=O)N(C)C 15299-99-7 N,N-DIETHYL-2-(1-NAPHTHYLOXY)PROPIONAMID C17H21NO2 271.36CCN(CC)C(C(C)Oc2c1ccccc1ccc2)=O 313-72-4 OCTAFLUORNAPHTHALIN C10F8 272.10Fc1c(F)c(c(F)c2F)c(c(F)c2F)c(F)c1F 81-60-7 1,4,5,8-TETRAHYDROXYANTHRACHINON C14H8O6 272.21Oc1ccc(O)c(C3=O)c1C(=O)c2c3c(O)ccc2O 50-28-2 (17BETA)-ESTRA-1,3,5(10)-TRIEN-3,17-DIOL C18H24O2 272.38OC1CCC4C3CCc2cc(O)ccc2C3CCC41C 57-91-0 a-estradiol C18H24O2 272.38OC1CCC4C3CCc2cc(O)ccc2C3CCC41C 2553-19-7 DIETHOXYDIPHENYLSILAN C16H20O2Si 272.42CCO[Si](OCC)(c2ccccc2)c1ccccc1 77-47-4 1,2,3,4,5,5-HEXACHLOR-1,3-CYCLOPENTADIEN C5Cl6 272.77ClC1(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl 131-54-4 2,2`-DIHYDROXY-4,4`-DIMETHOXYBENZOPHENON C15H14O5 274.27COc(ccc2C(=O)c1ccc(OC)cc1O)cc2O 87818-31-3 1-methyl-4-(1-methylethyl)-2-((2-methylphenyl)methoxy)-7-oxabicyclo[2.2.1]heptaneC18H26O2 274.40CC(C)C3(CC2)OC2(C)C(C3)OCc1ccccc1C 1459-10-5 TETRADECYLBENZOL C20H34 274.49CCCCCCCCCCCCCCc1ccccc1 119-15-3 2,4-DINITRO-4`-HYDROXYDIPHENYLAMIN C12H9N3O5 275.22Oc1ccc(Nc2ccc(cc2N(=O)=O)N(=O)=O)cc1 24973-59-9 1,3,5-tri(tert-butyl)-2-nitrosobenzene C18H29NO CC(C)(C)c(cc1C(C)(C)C)cc(C(C)(C)C)c1N=O275.43 77-93-0 TRIETHYLCITRAT C12H20O7 276.28CCOC(CC(O)(CC(OCC)=O)C(OCC)=O)=O 191-24-2 BENZO(GHI)PERYLEN C22H12 276.33c(cc1ccc3ccc4c5)cc6c1c3c4c2c6cccc2c5 139-39-5 indeno-[1,2,3-cd]-pyrene C22H12 276.33c(ccc1c(c6)c2c4c3c6cccc3c5)cc1c2ccc4c5 191-26-4 ANTHANTHREN C22H12 276.33c(cc1ccc3c6)cc5c1c3c4c2c6cccc2ccc4c5 66809-06-1 tricyclo[1.1.0.02,4]butane,tetrakis(t-butyl) C20H36 CC(C)(C)C21C3(C(C)(C)C)C1(C(C)(C)C)C32C(C)(C)C276.50 1089-84-5 3,5-dibromo-4-hydroxybenzonitrile C7H3Br2NO 276.91 N#Cc(cc1Br)cc(Br)c1O 630-70-6 iodotrinitromethane CIN3O6 276.93IC(N(=O)=O)(N(=O)=O)N(=O)=O 3582-71-6 1,5-DICHLOR-1,1,3,3,5,5-HEXAMETHYLTRISILOXAN C6H18Cl2O2Si3 277.37C[Si](C)(Cl)O[Si](C)(C)O[Si](C)(C)Cl 57239-20-0 p-chlorobenzylselenopropionicacid C10H11ClO2Se 277.61 OC(CC[Se]Cc(cc1)ccc1Cl)=O 57239-19-7 m-chlorobenzylselenopropionicacid C10H11ClO2Se 277.61 OC(CC[Se]Cc(ccc1)cc1Cl)=O 791-28-6 TRIPHENYLPHOSPHINOXID C18H15OP 278.29O=P(c3ccccc3)(c2ccccc2)c1ccccc1 55-38-9 O,O-DIMETHYL-O-(3-METHYL-4-(METHYLTHIO)-PHENYL)-THIOPHOSPHATC10H15O3PS2 278.33CSc1ccc(OP(OC)(OC)=S)cc1C 84-74-2 1,2-BENZOLDICARBONSAEUREDIBUTYLESTER C16H22O4 278.35CCCCOC(=O)c1ccccc1C(OCCCC)=O 84-69-5 1,2-BENZOLDICARBONSAEUREBIS(2-METHYLPROPYL)ESTERC16H22O4 278.35CC(C)COC(=O)c1ccccc1C(OCC(C)C)=O 215-58-7 1,2,3,4-DIBENZANTHRACEN C22H14 278.35c(ccc3cc4c1ccccc51)cc3cc4c2ccccc52 213-46-7 PICEN C22H14 278.35c(ccc2c4ccc3c1ccccc1ccc3c4c5)cc2c5 214-17-5 BENZO(B)CHRYSEN C22H14 278.35c(ccc2cc3c5ccc1ccccc1c5ccc3c4)cc42 53-70-3 DIBENZ(A,H)ANTHRACEN C22H14 278.35c(ccc1c3cc4c5)cc1ccc3cc4c2ccccc2c5 226-88-0 BENZONAPHTHACEN C22H14 278.35c(ccc52)cc2cc3cc4c1ccccc1ccc4cc3c5 222-93-5 PENTAPHEN C22H14 278.35c(ccc2cc3c4cc1ccccc1cc4ccc3c5)cc52 224-41-9 DIBENZ-(AJ)-ANTHRACEN C22H14 278.35c(ccc2c3cc4c1ccccc1ccc4cc3c5)cc2c5 135-48-8 BENZO(A)NAPHTHACEN C22H14 278.35c(ccc1cc3cc4cc2ccccc52)cc1cc3cc4c5

Page 108 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 27113-22-0 1-(4-hydroxy-3-methoxyphenyl)decan-3-one C17H26O3 278.39CCCCCCCC(CCc(ccc1O)cc1OC)=O 463-40-1 LINOLENSAEURE C18H30O2 278.43CCC=CCC=CCC=CCCCCCCCC(O)=O 6169-94-4 (1,8)-PARACYCLOPHAN C21H26 278.43C(CCCCc2ccc3cc2)CCCc1ccc(C3)cc1 765-27-5 1-EICOSIN C20H38 278.52CCCCCCCCCCCCCCCCCCC#C 62678-52-8 meso-3,4-dicyclohexyl-2,5-dimethylhexane C20H38 278.52CC(C)C(C1CCCCC1)C(C(C)C)C2CCCCC2 57837-19-1 N-(2,6-DIMETHYLPHENYL)-N-(METHOXYACETYL)-DL-ALANINMETHYLESTERC15H21NO4 279.33COCC(=O)N(C(C)C(OC)=O)c1c(C)cccc1C 226-36-8 DIBENZ(A,H)ACRIDIN C21H13N 279.34c(ccc1c3n5)cc1ccc3cc4c2ccccc2ccc54 215-62-3 DIBENZ(A,C)ACRIDIN C21H13N 279.34c(ccc3cc4c2ccccc52)cc3nc4c1ccccc51 224-42-0 DIBENZ(A,J)ACRIDIN C21H13N 279.34c(ccc1c3cc4c2ccccc2ccc54)cc1ccc3n5 224-53-3 DIBENZ(C,H)ACRIDIN C21H13N 279.34c(ccc2c4nc3c1ccccc1ccc3c5)cc2ccc54 590-27-2 E-1,2-DIIODETHEN C2H2I2 279.85 IC=CI 1067-53-4 2,5,7,10-TETRAOXA-6-SILAUNDECANE,6-ETHENYL-6-(2-METHOXYETHOXY)-C11H24O6Si 280.39COCCO[Si](OCCOC)(OCCOC)C=C 50-49-7 10,11-DIHYDRO-N,N-DIMETHYL-5H-DIBENZ(B,F)AZEPIN-5-PROPANAMINC19H24N2 280.41CN(C)CCCN3c1ccccc1CCc2ccccc32 60-33-3 (9Z,12Z)-9,12-OCTADECADIENSAEURE C18H32O2 280.45CCCCCC=CCC=CCCCCCCCC(O)=O 3452-07-1 1-EICOSEN C20H40 280.53CCCCCCCCCCCCCCCCCCC=C 42448-85-1 TRANS-2-EICOSENE C20H40 280.53CCCCCCCCCCCCCCCCCC=CC 1924-47-6 2,2-DINITRO-N-(2,2-DINITROPROPYL)-1-PROPANAMIN C6H11N5O8CC(CNCC(C)(N(=O)=O)N(=O)=O)(N(=O)=O)N(=O)=O281.18 79504-02-2 BROMPENTACHLORETHAN C2BrCl5 281.19 ClC(Cl)(Cl)C(Cl)(Cl)Br 31218-83-4 propan-2-yl (z)-3-(ethylamino-methoxyphosphinothioyl)oxybut-2-enoateC10H20NO4PS 281.31CC(C)OC(=O)C=C(C)OP(OC)(=S)NCC 39336-60-2 3,4-dimethyl-2,6-dinitro-n-pentan-3-ylaniline C13H19N3O4 CCC(CC)Nc(c(cc1C)N(=O)=O)c(c1C)N(=O)=O281.31 31842-01-0 4-(1,3-dihydro-1-oxo-isoindol-2-yl)-benzeneaceticacid C17H15NO3 281.31CC(C(O)=O)c2ccc(cc2)N3Cc1ccccc1C3=O 71357-27-2 1-(3-methylphenoxy)silatrane C13H19NO4Si 281.38Cc1cc(O[Si]2(OCC3)OCCN3CCO2)ccc1 51466-75-2 1-(4-methylphenoxy)silatrane C13H19NO4Si 281.38Cc1ccc(O[Si]2(OCC3)OCCN3CCO2)cc1 624-73-7 1,2-DIJODETHAN C2H4I2 281.86 ICCI 10409-06-0 DIPHENYLDISULFON C12H10O4S2 282.34O=S(c2ccccc2)(=O)S(c1ccccc1)(=O)=O 2314-09-2 9-HYDROXY-9H-FLUOREN-9-CARBONSAEUREBUTYLESTERC18H18O3 282.34CCCCOC(=O)C3(O)c1ccccc1c2ccccc32 90936-52-0 1-(3-aminophenoxy)silatrane C12H18N2O4Si 282.37Nc1cc(O[Si]2(OCC3)OCCN3CCO2)ccc1 2668-47-5 3,5-bis(1,1-dimethylethyl)-(1,1'-biphenyl)-4-ol C20H26O 282.42CC(C)(C)c2cc(c1ccccc1)cc(C(C)(C)C)c2O 502-26-1 5-tetradecyloxolan-2-one C18H34O2 282.46CCCCCCCCCCCCCCC1OC(CC1)=O 112-80-1 (9Z)-9-OCTADECENSAEURE C18H34O2 282.46CCCCCCCCC=CCCCCCCCC(O)=O 112-95-8 EICOSAN C20H42 282.55CCCCCCCCCCCCCCCCCCCC 16066-09-4 tetrasiloxane,1,1,1,3,5,7,7,7-octamethyl- C8H26O3Si4 282.63C[SiH](O[SiH](C)O[Si](C)(C)C)O[Si](C)(C)C 124-26-5 OCTADECANAMID C18H37NO 283.49CCCCCCCCCCCCCCCCCC(=O)N 51218-45-2 2-CHLOR-N-(2-ETHYL-6-METHYLPHENYL)-N-(2-METHOXY-1-METHYLETHYL)ACETAMIDC15H22ClNO2 283.80COCC(C)N(c1c(CC)cccc1C)C(CCl)=O 16752-60-6 PHOSPHORPENTOXID_DIMER O10P4 283.89O=P3(O1)OP(OP1(O2)=O)(OP2(O3)=O)=O 1314-56-3 DIPHOSPHORPENTOXID O10P4 283.89O=P1(O2)OP(OP2(O3)=O)(OP3(O1)=O)=O 92114-99-3 4`-NITRO-3-METHYL-4-(N,N-DIMETHYLAMINO)AZOBENZENC15H16N4O2 284.31CN(C)c2ccc(N=Nc1ccc(cc1)N(=O)=O)cc2C 58-40-2 primazine C17H20N2S 284.42CN(C)CCCn3c1ccccc1sc2ccccc32 57-11-4 OCTADECANSAEURE C18H36O2 284.48CCCCCCCCCCCCCCCCCC(O)=O 628-97-7 HEXADECANSAEUREETHYLESTER C18H36O2 284.48CCCCCCCCCCCCCCCC(OCC)=O 1454-84-8 1-NONADECANOL C19H40O 284.52OCCCCCCCCCCCCCCCCCCC 80-32-0 4-AMINO-N-(6-CHLOR-3-PYRIDAZINYL)BENZOLSULFONAMIDC10H9ClN4O2S 284.72Clc2ccc(nn2)NS(c(cc1)ccc1N)(=O)=O 439-14-5 7-CHLORO-1,3-DIHYDRO-1-METHYL-5-PHENYL-2H-1,4-BE C16H13ClN2O 284.74Clc(ccc2N3C)cc2C(c1ccccc1)=NCC3=O 118-74-1 HEXACHLORBENZOL C6Cl6 284.78 Clc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl 94-62-2 (E,E)-1-(5-(1,3-BENZODIOXOL-5-YL)-1-OXO-2,4-PENTADIENYL)PIPERIDINC17H19NO3 285.34O=C(N1CCCCC1)C=CC=Cc3cc2OCOc2cc3 14309-25-2 TRIPHENYLMETHYLAZID C19H15N3 285.34N#N=NC(c3ccccc3)(c2ccccc2)c1ccccc1 1446-61-3 DEHYDROABIETYLAMINE C20H31N 285.47NCC2(C)CCCC3(C)c1ccc(C(C)C)cc1CCC32 1561-49-5 PEROXYDIKOHLENSAEUREDICYCLOHEXYLESTER C14H22O6 286.32O=C(OC1CCCCC1)OOC(OC2CCCCC2)=O 4792-83-0 4,4-AZOXYPHENETOL C16H18N2O3 286.33CCOc1ccc(cc1)N=N(c(cc2)ccc2OCC)=O 505-54-4 HEXADECANDISAEURE C16H30O4 286.41OC(CCCCCCCCCCCCCCC(O)=O)=O 6846-50-0 PROPANOICACID,2-METHYL-,2,2-DIMETHYL-1-(1-METHYLETHYL)-1,3-PROPANEDIYLESTERC16H30O4 CC(C)C(C(C)(C)COC(C(C)C)=O)OC(C(C)C)=O286.41 762-16-3 di-n-octanoylperoxide C16H30O4 286.41CCCCCCCC(OOC(CCCCCCC)=O)=O 56-33-7 1,1,3,3-TETRAMETHYL-1,3-DIPHENYLDISILOXAN C16H22OSi2 286.52C[Si](C)(O[Si](C)(C)c1ccccc1)c2ccccc2 604-75-1 7-CHLOR-1,3-DIHYDRO-3-HYDROXY-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONC15H11ClN2O2 286.71OC3N=C(c1ccccc1)c2cc(Cl)ccc2NC3=O 479-45-8 N-METHYL-N-NITRO-2,4,6-TRINITROANILIN C7H5N5O8 CN(c1c(cc(cc1N(=O)=O)N(=O)=O)N(=O)=O)N(=O)=O287.14 67028-17-5 dibenzo[b,e][1,4]dioxin,1,3,7-trichloro- C12H5Cl3O2 287.53Clc(ccc1Oc2cc3Cl)cc1Oc2c(Cl)c3 39227-58-2 1,2,4-TRICHLORDIBENZO(B,E)(1,4)DIOXIN C12H5Cl3O2 287.53Clc3cc(Cl)c2Oc1ccccc1Oc2c3Cl 678-26-2 DODECAFLUORPENTAN C5F12 288.03FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F 34835-05-7 p-nitrobenzylselenopropionicacid C10H11NO4Se 288.16OC(CC[Se]Cc1ccc(cc1)N(=O)=O)=O 2180-92-9 bupivacaine C18H28N2O 288.43CCCCN1CCCCC1C(=O)Nc2c(C)cccc2C 58-22-0 TESTOSTERON C19H28O2 OC1CCC3C4CCC2=CC(CCC2(C)C4CCC31C)=O288.43 2131-18-2 PENTADECYLBENZOL C21H36 288.51CCCCCCCCCCCCCCCc1ccccc1

Page 109 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 154144-93-1 2-(4-chlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)hexanenitrile C15H17ClN4 288.78CCCCC(C#N)(Cn1cncn1)c(cc2)ccc2Cl 81335-77-5 5-ethyl-2-(4-methyl-5-oxo-4-propan-2-yl-1h-imidazol-2-yl)pyridine-3-carboxylicC15H19N3O3 CCc(cnc1C(=NC2(C)C(C)C)NC2=O)cc1C(O)=O289.33 acid 51-55-8 ALPHA-(HYDROXYMETHYL)BENZOLESSIGSAEURE((3-ENDO)-(+-)-8-METHYL-8-AZABICYCLO(3.2.1C17H23NO3 289.37CN2C3CCC2CC(C3)OC(=O)C(CO)c1ccccc1 738-70-5 2,4-DIAMINO-5-(3,4,5-TRIMETHOXYBENZYL)-PYRIMIDIN C14H18N4O3 290.32COc2cc(Cc1cnc(N)nc1N)cc(OC)c2OC 59358-70-2 1,1-(1,1-BICYCLOPENTYL)-1,1-DIYLBISBENZOL C22H26 290.44C(CCC1(C2(CCCC2)c4ccccc4)c3ccccc3)C1 31147-36-1 (2e)-1-[(2e)-3,7-dimethylocta-2,6-dienoxy]-3,7-dimethylocta-2,6-dieneC20H34O CC(C)=CCCC(C)=CCOCC=C(C)CCC=C(C)C290.49 1982-47-4 CHLOROXURON C15H15ClN2O2 290.75Clc2ccc(Oc1ccc(cc1)NC(=O)N(C)C)cc2 58-89-9 HEXACHLORCYCLOHEXAN C6H6Cl6 290.83ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl 319-84-6 ALPHA-HEXACHLORCYCLOHEXAN C6H6Cl6 290.83ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl 6108-10-7 (1ALPHA,2ALPHA,3ALPHA,4BETA,5BETA,6BETA)-1,2,3,4,5,6-HEXACHLORCYCLOHEXANC6H6Cl6 290.83ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl 319-85-7 BETA-HEXACHLORCYCLOHEXAN C6H6Cl6 290.83ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl 319-86-8 DELTA-HEXACHLORCYCLOHEXAN C6H6Cl6 290.83ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl 56-38-2 O,O-DIETHYL-O-(4-NITROPHENYL)-THIOPHOSPHAT C10H14NO5PS 291.26CCOP(OCC)(Oc1ccc(cc1)N(=O)=O)=S 298-00-0 PARATHION-METHYL C10H14NO5PS 291.26CCOP(OCC)(Oc1ccc(cc1)N(=O)=O)=S 4074-25-3 1,3,5-TRIS(1,1-DIMETHYLETHYL)-2-NITROBENZOL C18H29NO2 CC(C)(C)c(cc1C(C)(C)C)cc(C(C)(C)C)c1N(=O)=O291.43 15968-05-5 2,2`,6,6`-TETRACHLORBIPHENYL C12H6Cl4 291.99 Clc1cccc(Cl)c1c2c(Cl)cccc2Cl 35693-99-3 2,2`,5,5`-TETRACHLORBIPHENYL C12H6Cl4 291.99 Clc(ccc2Cl)cc2c1cc(Cl)ccc1Cl 60-00-4 ETHYLENDIAMINTETRAESSIGSAEURE C10H16N2O8 OC(CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)=O292.24 301-00-8 (9Z,12Z,15Z)-9,12,15-OCTADECATRIENSAEUREMETHYLESTERC19H32O2 292.46COC(CCCCCCCC=CCC=CCC=CCC)=O 27745-90-0 2,10,3A,8A,5,7-(1,2,3,4,5,6-HEXANHEXAYL)HEXADECAHYDROPYRENC22H28C(C(CC8C1C5)CC72C98)C1C2C4C53CC(CC6C93)CC4C6C7292.46 2077-99-8 2,6-dinitro-n-propyl-4-trifluoromethylbenzeneamine C10H10F3N3O4 CCCNc1c(cc(C(F)(F)F)cc1N(=O)=O)N(=O)=O293.20 33089-61-1 n'-(2,4-dimethylphenyl)-n-[(2,4-dimethylphenyl)iminomethyl]-n-methylmethanimidamideC19H23N3 293.41Cc(ccc1N=CN(C)C=Nc2ccc(C)cc2C)cc1C 81-14-1 2,6-DIMETHYL-3,5-DINITRO-4-TERT.-BUTYLACETOPHENONC14H18N2O5CC(C)(C)c(c(c1C)N(=O)=O)c(c(C)c1C(C)=O)N(=O)=O294.30 22839-47-0 3-amino-4-[(1-methoxy-1-oxo-3-phenylpropan-2-yl)amino]-4-oxobutanoicC14H18N2O5 acidCOC(=O)C(Cc1ccccc1)NC(C(N)CC(O)=O)=O294.30 963-14-4 4-amino-n-(6-ethoxypyridazin-3-yl)benzenesulfonamide C12H14N4O3S 294.33CCOc2ccc(nn2)NS(c(cc1)ccc1N)(=O)=O 485-71-2 (8ALPHA,9R)-CINCHONAN-9-OL C19H22N2O 294.39OC(C4CC3CCN4CC3C=C)c2c1ccccc1ncc2 118-10-5 (9S)-CINCHONAN-9-OL C19H22N2O 294.39OC(C3CC4CCN3CC4C=C)c2c1ccccc1ncc2 112-63-0 (9Z,12Z)-9,12-OCTADECADIENSAEUREMETHYLESTER C19H34O2 294.47CCCCCC=CCC=CCCCCCCCC(OC)=O 6812-39-1 HEXADECYLCYCLOPENTAN C21H42 294.56CCCCCCCCCCCCCCCCC1CCCC1 33629-47-9 butralin C14H21N3O4 CCC(C)Nc1c(cc(C(C)(C)C)cc1N(=O)=O)N(=O)=O295.34 82-68-8 PENTACHLORNITROBENZOL C6Cl5NO2 295.34Clc1c(Cl)c(Cl)c(c(Cl)c1Cl)N(=O)=O 90936-53-1 1-(4-ethylphenoxy)silatrane C14H21NO4Si 295.41CCc1ccc(O[Si]2(OCC3)OCCN3CCO2)cc1 90955-56-9 1-(3,5-dimethylphenoxy)silatrane C14H21NO4Si 295.41Cc1cc(O[Si]2(OCC3)OCCN3CCO2)cc(C)c1 15307-86-5 DICLOFENAC C14H11Cl2NO2 296.15OC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl 2691-41-0 1,3,5,7-CYCLOTETRAMETHYLENTETRANITRAMIN C4H8N8O8O=N(=O)N1CN(CN(CN(C1)N(=O)=O)N(=O)=O)N(=O)=O296.16 7396-89-6 2-HYDROXY-3-TRIFLUOROMETHYL-4-METHOXYBENZOPHENOC15H11F3O3 296.24COc(ccc2C(=O)c(ccc1)cc1C(F)(F)F)cc2O 7396-90-9 2-HYDROXY-4-METHOXY-4`-(TRIFLUOROMETHYL)-BENZOPHENONC15H11F3O3 296.24COc(ccc2C(=O)c(cc1)ccc1C(F)(F)F)cc2O 57-63-6 (17ALPHA)-19-NORPREGNA-1,3,5(10)-TRIEN-20-IN-3,17-DIOLC20H24O2 CC41CCC3c2ccc(O)cc2CCC3C4CCC1(O)C#C296.41 112-62-9 (9Z)-9-OCTADECENSAEUREMETHYLESTER C19H36O2 296.49CCCCCCCCC=CCCCCCCCC(OC)=O 150-86-7 PHYTOL C20H40O 296.53CC(C)CCCC(C)CCCC(C)CCCC(C)=CCO 629-94-7 HENICOSAN C21H44 296.58CCCCCCCCCCCCCCCCCCCCC 556-67-2 OCTAMETHYLCYCLOTETRASILOXAN C8H24O4Si4 C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1296.62 34645-84-6 2-(2,4-DICHLORPHENOXY)BENZOLESSIGSAEURE C14H10Cl2O3 297.14OC(=O)Cc1ccccc1Oc2ccc(Cl)cc2Cl 35554-44-0 1-[2-(2,4-dichlorophenyl)-2-prop-2-enoxyethyl]imidazole C14H14Cl2N2O 297.18C=CCOC(Cn1ccnc1)c2ccc(Cl)cc2Cl 81-15-2 1,3-DIMETHYL-5-TERT.-BUTYL-2,4,6-TRINITROBENZOL C12H15N3O6CC(C)(C)c(c(c1C)N(=O)=O)c(c(C)c1N(=O)=O)N(=O)=O297.27 58-93-5 3,4-dihydro-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxideC7H8ClN3O4S2 297.74Clc1cc(NCNS2(=O)=O)c2cc1S(=O)(=O)N 3025-52-3 4-NITRO-4`-(DIETHYLAMINO)-AZOBENZOL C16H18N4O2 298.34CCN(CC)c2ccc(N=Nc1ccc(cc1)N(=O)=O)cc2 646-30-0 NONADECANSAEURE C19H38O2 298.51CCCCCCCCCCCCCCCCCCC(O)=O 112-61-8 OCTADECANSAEUREMETHYLESTER C19H38O2 298.51CCCCCCCCCCCCCCCCCC(OC)=O 629-96-9 1-EICOSANOL C20H42O 298.55OCCCCCCCCCCCCCCCCCCCC 43210-67-9 methyl n-(6-phenylsulfanyl-1h-benzimidazol-2-yl)carbamate C15H13N3O2S 299.35COC(=O)Nc(nc1cc3)[nH]c1cc3Sc2ccccc2 57-27-2 (5ALPHA,6ALPHA)-7,8-DIDEHYDRO-4,5-EPOXY-17-METHYLMORPHINAN-3,6-DIOLC18H21NO3 CN5CCCC31c4c2OC1C(O)C=CC3C5Cc4ccc2O299.37 224-62-4 14h-dibenzo[a,j]phenothiazine C20H13NS 299.39c(ccc2c4[nH]c3c1ccccc1ccc3s5)cc2ccc54 224-72-6 7h-dibenzo[c,h]phenothiazine C20H13NS 299.39c(ccc2c4sc3c1ccccc1ccc3[nH]5)cc2ccc54 755-25-9 PERFLUOR-1-HEXEN C6F12 300.05FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)=C(F)F 1805-22-7 NONAFLUOR(TRIFLUORMETHYL)CYCLOPENTAN C6F12 300.05FC(F)(F)C(F)(C(F)(F)C1(F)F)C(F)(F)C1(F)F 355-68-0 DODECAFLUORCYCLOHEXAN C6F12 300.05FC1(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C1(F)F 918-37-6 HEXANITROETHAN C2N6O12O=N(=O)C(C(N(=O)=O)(N(=O)=O)N(=O)=O)(N(=O)=O)N(=O)=O300.06 1562-85-2 gallocyanine C15H12N2O5CN(C)c(ccc1N=C2C(C(O)=O)=CC3=O)cc1OC2=C3O300.27 13684-56-5 (3-(((PHENYLAMINO)CARBONYL)OXY)PHENYL)CARBAMIDSAEUREETHYLESTERC16H16N2O4 300.31CCOC(=O)Nc(ccc2)cc2OC(=O)Nc1ccccc1 59-40-5 4-AMINO-N-2-CHINOXALINYLBENZOLSULFONAMID C14H12N4O2S 300.34Nc2ccc(cc2)S(=O)(=O)Nc3nc1ccccc1nc3 63837-33-2 diofenolan C18H20O4 300.35CCC3OC(CO3)COc2ccc(Oc1ccccc1)cc2

Page 110 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 191-07-1 CORONEN C24H12 c(cc2ccc4c6)c1ccc3ccc(ccc5c6)c7c3c1c2c4c75300.35 1740-19-8 1-PHENANTHRENECARBOXYLICACID,1,2,3,4,4A,9,10,10A-OCTAHYDRO-1,4A-DIMETHYL-7-(1-C20H28O2 CC2(CCCC3(C)c1ccc(C(C)C)cc1CCC32)C(O)=O300.44 120528-25-8 2-(trichloromethylsulfanyl)-3a,4,7,7a-tetrahydroisoindole-1,3-dioneC9H8Cl3NO2S 300.59ClC(Cl)(Cl)SN2C(C1CC=CCC1C2=O)=O 6166-86-5 2,4,6,8,10-PENTAMETHYLCYCLOPENTASILOXAN C5H20O5Si5 C[SiH]1O[SiH](C)O[SiH](C)O[SiH](C)O[SiH](C)O1300.64 1067-42-1 TETRABUTYLGERMAN C16H36Ge 301.10CCCC[Ge](CCCC)(CCCC)CCCC 72490-01-8 [2-(4-phenoxyphenoxy)ethyl]-carbamicacidethylester C17H19NO4 301.34CCOC(=O)NCCOc2ccc(Oc1ccccc1)cc2 86825-39-0 1-(3-chlorophenoxy)silatrane C12H16ClNO4Si 301.80Clc1cc(O[Si]2(OCC3)OCCN3CCO2)ccc1 51466-76-3 1-(4-chlorophenoxy)silatrane C12H16ClNO4Si 301.80Clc1ccc(O[Si]2(OCC3)OCCN3CCO2)cc1 2611-53-2 o-diselenane-3,6-dicarboxylicacid C6H8O4Se2 302.05OC(C1[Se][Se]C(CC1)C(O)=O)=O 950-37-8 DITHIOPHOSPHORSAEURE-S-((5-METHOXY-2-OXO-1,3,4-THIADIAZOL-3(2H)-YL)METHYL)-O,O-DC6H11N2O4PS3 302.33COP(OC)(SCN1N=C(OC)SC1=O)=S 60-01-5 BUTANSAEURE-1,2,3-PROPANTRIYLESTER C15H26O6 302.36CCCC(OCC(COC(CCC)=O)OC(CCC)=O)=O 192-51-8 DIBENZO(FG,OP)NAPHTHACEN C24H14 302.37c(ccc51)cc1c(cccc3c2ccccc62)c3c4c5cccc64 192-65-4 NAPHTHO(1,2,3,4-DEF)CHRYSEN C24H14 302.37c(ccc1c4ccc3cccc6c3c4c5c2ccccc62)cc1c5 5835-26-7 [1R-(1ALPHA,4ABETA,4BALPHA,7ALPHA,10AALPHA)]-7ETHENYL-1,2,3,4,4A,4B,5,6,7,8C20H30O2 CC32CCCC(C)(C2CC=C(CC1(C)C=C)C3CC1)C(O)=O302.45 471-77-2 NEOABIETICACID C20H30O2 CC2(CCCC3(C)C1CCC(=C(C)C)C=C1CCC32)C(O)=O302.45 127-27-5 7-ETHENYL-1,2,3,4,4A,4B,5,6,7,9,10-10A-DODECAHYDRO-1,4A,7-TRIMETHYL-1-PHENANTHREC20H30O2 CC32CCCC(C)(C2CCC(C3CC1)=CC1(C)C=C)C(O)=O302.45 514-10-3 (1R-(1ALPHA,4ABETA,4BALPHA,10AALPHA))-1,2,3,4,4A,5,6,10,10A-DECAHYDRO-1,4A-DIMETC20H30O2 CC2(CCCC3(C)C1CCC(C(C)C)=CC1=CCC32)C(O)=O302.45 1945-53-5 PHENANTHRENECARBOXYLICACID,1,2,3,4,4A,5,6,9,10,10A-DECAHYDRO-1,4A-DIMETHYL-7-(C20H30O2 CC(CCC32C)(CC2CCC(=C3CC1)C=C1C(C)C)C(O)=O302.45 1459-09-2 HEXADECYLBENZOL C22H38 302.54CCCCCCCCCCCCCCCCc1ccccc1 62678-54-0 meso-3,4-di-1-cyclohexen-1-yl-2,2,5,5-tetramethylh C22H38 CC(C)(C)C(C(C(C)(C)C)C2=CCCCC2)C1=CCCCC1302.54 521-74-4 5,7-DIBROM-8-CHINOLINOL C9H5Br2NO 302.95 Brc2cc(Br)c1cccnc1c2O 75631-81-1 5-nitro-2-acetoxy-2,5-dihydrofurfuraldiacetate C11H13NO9CC(OC(OC(C)=O)C1(OC(C)=O)C=CC(O1)N(=O)=O)=O303.22 50-36-2 (1R-(EXO,EXO))-3-(BENZOYLOXY)-8-METHYL-8-AZABICYCLO(3.2.1)OCTAN-2-CARBONSAEUREMEC17H21NO4 CN2C3CCC2CC(C3C(OC)=O)OC(=O)c1ccccc1303.35 27314-13-2 norflurazon C12H9ClF3N3O FC(F)(F)c1cc(ccc1)N2N=CC(NC)=C(Cl)C2=O303.67 632-58-6 3,4,5,6-tetrachloro-1,2-benzenedicarboxylicacid C8H2Cl4O4 303.91OC(=O)c(c(Cl)c1Cl)c(C(O)=O)c(Cl)c1Cl 7370-58-3 3,3'-diselenobispropanoicacid C6H10O4Se2 304.07 OC(CC[Se][Se]CCC(O)=O)=O 56079-22-2 o-nitrosonitrobenzenedimer C12H8N4O6 O=N(=O)c1ccccc1N(=O)=N(c2ccccc2N(=O)=O)=O304.22 1516-80-9 ETHOXYTRIPHENYLSILAN C20H20OSi 304.46CCO[Si](c3ccccc3)(c2ccccc2)c1ccccc1 17990-11-3 1-NAPHTHALENECARBOXALDEHYDE,DECAHYDRO-5-(5-HYDROXY-3-METHYL-3-PENTENYL)-1,4A-DIC20H32O2 OCC=C(C)CCC(C1(C)CCC2)C(CCC1C2(C)C=O)=C304.47 85688-86-4 TETRAKIS(2-METHYLPROPYL)BUTANDINITRIL C20H36N2 CC(C)CC(CC(C)C)(C(CC(C)C)(CC(C)C)C#N)C#N304.52 35048-13-6 7-CHLOR-5-IOD-8-QUINOLINOL C9H5ClINO 305.50 Clc2cc(I)c1cccnc1c2O 104549-76-0 silaprocyclidine C18H31NOSi O[Si](CCN1CCCC1)(C2CCCCC2)C=CC=CC=C305.53 51207-31-9 2,3,7,8-tetrachlorodibenzofuran C12H4Cl4O 305.97Clc2cc1oc(cc3Cl)c(cc3Cl)c1cc2Cl 24478-72-6 1,2,3,4-tetrachlorodibenzofuran C12H4Cl4O 305.97Clc3c(Cl)c2oc1ccccc1c2c(Cl)c3Cl 603-32-7 TRIPHENYLARSIN C18H15As 306.23c(cc1)ccc1[As](c3ccccc3)c2ccccc2 86386-73-4 1h-1,2,4-triazole-1-ethanol C13H12F2N6O 306.27OC(Cn2cncn2)(Cn1cncn1)c3ccc(F)cc3F 641-13-4 DIBENZO(DEF,MNO)-CHRYSEN-6,12-DION C22H10O2 O=C5c1cccc(ccc63)c1c3c4c2c(cccc2C6=O)ccc54306.32 135-70-6 P-QUATERPHENYL C24H18 306.40c(cc2)ccc2c4ccc(cc4)c(cc3)ccc3c1ccccc1 612-71-5 1,3,5-TRIPHENYLBENZOL C24H18 306.40c(cc3)ccc3c4cc(c1ccccc1)cc(c2ccccc2)c4 1857-24-5 1-NAPHTHALENEMETHANOL,DECAHYDRO-5-(5-HYDROXY-3-METHYL-3-PENTENYL)-1,4A-DIMETHYLC20H34O2 OCC2(C)C1CCC(C(CCC(C)=CCO)C1(C)CCC2)=C306.48 1191-41-9 ethyl-linolenate C20H34O2 306.48CCOC(CCCCCCCC=CCC=CCC=CCC)=O 3029-32-1 6,13-pentacenedione C22H12O2 O=C5c3cc1ccccc1cc3C(=O)c4cc2ccccc2cc54308.33 81-81-2 3-(1'-phenyl-2'-acetylethyl)-4-hydroxycoumarin C19H16O4 CC(=O)CC(c1ccccc1)C3=C(O)c2ccccc2OC3=O308.33 33574-11-7 PHENYL(2,4,6-TRIS(1-METHYLETHYL)PHENYL)METHANON C22H28O CC(C)c(cc2C(C)C)cc(C(C)C)c2C(=O)c1ccccc1308.46 33574-16-2 3',5'-diisopropyl-4,4-dimethyl-3-phenyl-1,2-benzocyclobuten-3-ol C22H28O CC(C)c(cc3C(C)C)cc(C2(C)C)c3C2(O)c1ccccc1308.46 544-35-4 LINOLSAEUREETHYLESTER C20H36O2 308.50CCCCCC=CCC=CCCCCCCCC(OCC)=O 1599-67-3 1-DOCOSENE C22H44 308.59CCCCCCCCCCCCCCCCCCCCC=C 33820-53-0 isopropalin C15H23N3O4 CCCN(CCC)c1c(cc(C(C)C)cc1N(=O)=O)N(=O)=O309.36 42200-33-9 corgard C17H27NO4 309.40OC(CNC(C)(C)C)COc1cccc(CC2O)c1CC2O 125-58-6 (R)-6-DIMETHYLAMINO-4,4-DIPHENYL-3-HEPTANON C21H27NO CN(C)C(C)CC(C(CC)=O)(c2ccccc2)c1ccccc1309.45 28464-26-8 2,2,2`,2`-TETRANITRO-N-NITROSODIPROPYLAMIN C6H10N6O9CC(CN(CC(C)(N(=O)=O)N(=O)=O)N=O)(N(=O)=O)N(=O)=O310.18 101-60-0 21h,23h-porphine C20H14N4 C3=Cc5cc4[nH]c(cc(C=C2)nc2cc(cc1)[nH]c1cc3n5)cc4310.35 60628-96-8 bifonazole C22H18N2 310.39c(cc3)ccc3C(n1ccnc1)c4ccc(cc4)c2ccccc2 72-33-3 (17ALPHA)-3-METHOXY-19-NORPREGNA-1,3,5(10)-TRIEN-20-YN-17-OLC21H26O2 CC41CCC3c2ccc(OC)cc2CCC3C4CCC1(O)C#C310.43 47189-08-2 1,4-BIS-(1,1-DIETHOXYETHYL)-BENZOL C18H30O4 310.43CCOC(C)(OCC)c1ccc(C(C)(OCC)OCC)cc1 40596-69-8 propan-2-yl (2e,4e)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoateC19H34O3 COC(C)(C)CCCC(C)CC=CC(C)=CC(OC(C)C)=O310.47 111-62-6 (9Z)-9-OCTADECENSAEUREETHYLESTER C20H38O2 310.52CCCCCCCCC=CCCCCCCCC(OCC)=O 2495-27-4 CETYLMETHACRYLAT C20H38O2 310.52CCCCCCCCCCCCCCCCOC(=O)C(C)=C 629-97-0 DOCOSAN C22H46 310.60CCCCCCCCCCCCCCCCCCCCCC 141-62-8 DECAMETHYLTETRASILOXAN C10H30O3Si4 C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C310.69 1666-13-3 DIPHENYLDISELENIDE C12H10Se2 312.13 [Se]([Se]c1ccccc1)c2ccccc2 85-68-7 BENZYLBUTYLPHTHALAT C19H20O4 312.36CCCCOC(=O)c2ccccc2C(OCc1ccccc1)=O

Page 111 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 14098-24-9 benzo-18-crown-6-ether C16H24O6 312.36O2CCOCCOc1ccccc1OCCOCCOCC2 506-30-9 EICOSANSAEURE C20H40O2 312.53CCCCCCCCCCCCCCCCCCCC(O)=O 111-61-5 STEARINSAEUREETHYLESTER C20H40O2 312.53CCCCCCCCCCCCCCCCCC(OCC)=O 76-57-3 (5ALPHA,6ALPHA)-7,8-DIDEHYDRO-4,5-EPOXY-3-METHOXY-17-METHYLMORPHINAN-6-OLC19H23NO3 CN5CCCC31c4c2OC1C(O)C=CC3C5Cc4ccc2OC313.39 7700-17-6 crotoxyphos(ciodrin) C14H19O6P COP(OC)(=O)OC(C)=CC(OC(C)c1ccccc1)=O314.27 66032-51-7 1,4-BENZENEDICARBOXYLICACID,BIS(2,3-DIHYDROXYPROPYL)ESTERC14H18O8 OCC(O)COC(=O)c1ccc(C(OCC(O)CO)=O)cc1314.29 4395-65-7 9,10-anthracenedione,1-amino-4-(phenylamino)- C20H14N2O2 Nc3ccc(Nc1ccccc1)c4c3C(=O)c2ccccc2C4=O314.34 2872-52-8 4-NITRO-4`-(N-ETHYL-N-2-HYDROXYETHYLAMINO)-AZOBENZOLC16H18N4O3 OCCN(CC)c2ccc(N=Nc1ccc(cc1)N(=O)=O)cc2314.34 110-33-8 HEXANDISAEUREDIHEXYLESTER C18H34O4 314.46CCCCCCOC(CCCCC(OCCCCCC)=O)=O 109-43-3 DECANDISAEUREDIBUTYLESTER C18H34O4 314.46CCCCOC(CCCCCCCCC(OCCCC)=O)=O 57-83-0 PREGN-4-EN-3,20-DION C21H30O2CC41C(CCC1C3CCC2=CC(CCC2(C)C3CC4)=O)C(C)=O314.46 615-54-3 1,2,4-TRIBROMBENZOL C6H3Br3 314.80 Brc(ccc1Br)cc1Br 626-39-1 1,3,5-TRIBROMBENZOL C6H3Br3 314.80 Brc1cc(Br)cc(Br)c1 97-17-6 diethyl-2,4-dichlorophenylthiophosphate0 C10H13Cl2O3PS 315.16CCOP(OCC)(Oc1ccc(Cl)cc1Cl)=S 85509-19-9 flusilazole C16H15F2N3Si 315.39C[Si](Cn1cncn1)(c(cc3)ccc3F)c(cc2)ccc2F 78-11-5 2,2-BIS((NITROOXY)METHYL)-1,3-PROPANDIOLDINITRAT C5H8N4O12O=N(OCC(CON(=O)=O)(CON(=O)=O)CON(=O)=O)=O316.14 1812-30-2 bromazepam C14H10BrN3O 316.15Brc3cc2c(cc3)NC(CN=C2c1ccccn1)=O 14262-60-3 2,3-dibenzo-15-crown-5-ether0 C18H20O5 316.35O3CCOc1ccccc1OCCOc2ccccc2OCC3 127-25-3 methylabietate C21H32O2COC(C3(C)C2CC=C1C=C(C(C)C)CCC1C2(C)CCC3)=O316.48 14752-75-1 HEPTADECYLBENZOL C23H40 316.57CCCCCCCCCCCCCCCCCc1ccccc1 37894-46-5 etacelasil C11H25ClO6Si 316.85COCCO[Si](CCCl)(OCCOC)OCCOC 86-50-0 AZINPHOS-METHYL C10H12N3O3PS2 317.33COP(OC)(SCN2N=Nc1ccccc1C2=O)=S 72-55-9 1,1-DICHLOR-2,2-BIS(P-CHLORPHENYL)-ETHEN C14H8Cl4 318.03Clc1ccc(cc1)C(=C(Cl)Cl)c(cc2)ccc2Cl 94-01-9 1,3-phenylenedibenzoate C20H14O4 318.32O=C(Oc(ccc3)cc3OC(=O)c2ccccc2)c1ccccc1 59358-71-3 1,1-(1,1-BICYCLOHEXYL)-1,1-DIYLBISBENZOL C24H30 C(CC3)CCC3(C4(CCCCC4)c2ccccc2)c1ccccc1318.50 1836-77-7 1,3,5-TRICHLOR-2-(4-NITROPHENOXY)BENZOL C12H6Cl3NO3 318.54Clc(cc2Cl)cc(Cl)c2Oc1ccc(cc1)N(=O)=O 50-53-3 2-chloro-n,n-dimethyl-10h-phenothiazine-10-propanamine C17H19ClN2S 318.87CN(C)CCCn3c2cc(Cl)ccc2sc1ccccc31 34460-47-4 ethyl-4-cyanophenylphenylthiophosphate0 C15H14NO3PS 319.32CCOP(Oc1ccccc1)(Oc(cc2)ccc2C#N)=S 630-76-2 TETRAPHENYLMETHAN C25H20 320.43c(cc1)ccc1C(c4ccccc4)(c3ccccc3)c2ccccc2 4384-23-0 (6,6)-PARACYCLOPHAN C24H32 320.51c13ccc(cc1)CCCCCCc2ccc(cc2)CCCCCC3 846-49-1 7-CHLOR-5-(2-CHLORPHENYL)-1,3-DIHYDRO-3-HYDROXY-2H-1,4-BENZODIAZEPIN-2-ONC15H10Cl2N2O2 321.16OC3N=C(c1ccccc1Cl)c2cc(Cl)ccc2NC3=O 299-84-3 FENCHLORFOS_(RONNEL) C8H8Cl3O3PS 321.55COP(OC)(Oc(cc1Cl)c(Cl)cc1Cl)=S 1746-01-6 2,3,7,8-TETRACHLORDIBENZO(B,E)(1,4)DIOXIN C12H4Cl4O2 321.97Clc2cc1Oc(cc3Cl)c(Oc1cc2Cl)cc3Cl 43169-99-9 p-bromobenzylselenopropionicacid C10H11BrO2Se 322.06 OC(CC[Se]Cc1ccc(Br)cc1)=O 298-07-7 DI-2-ETHYLHEXYLPHOSPHORSAEURE C16H35O4P 322.42CCCCC(CC)COP(O)(OCC(CC)CCCC)=O 56-75-7 (R-(R*,R*))-2,2-DICHLOR-N-(2-HYDROXY-1-(HYDROXYMETHYL)-2-(4-NITROPHENYL)ETHYL)ACC11H12Cl2N2O5 OCC(C(O)c1ccc(cc1)N(=O)=O)NC(C(Cl)Cl)=O323.13 130-95-0 (-)-CHININ C20H24N2O2 COc(ccc1ncc2)cc1c2C(O)C3CC4CCN3CC4C=C324.42 56-54-2 (9S)-6-METHOXYCINCHONAN-9-OL C20H24N2O2 COc(ccc1ncc2)cc1c2C(O)C3CC4CCN3CC4C=C324.42 638-67-5 TRICOSAN C23H48 324.63CCCCCCCCCCCCCCCCCCCCCCC 630-25-1 1,2-DIBROM-1,1,2,2-TETRACHLORETHAN C2Br2Cl4 325.64 ClC(Cl)(Br)C(Cl)(Cl)Br 28464-24-6 N-(2,2-DINITROPROPYL)-N,2,2-TRINITRO-1-PROPANAMIN C6H10N6O10CC(CN(CC(C)(N(=O)=O)N(=O)=O)N(=O)=O)(N(=O)=O)N(=O)=O326.18 115-86-6 TRIPHENYLPHOSPHAT C18H15O4P 326.28O=P(Oc3ccccc3)(Oc2ccccc2)Oc1ccccc1 37680-73-2 2,2`,4,5,5`-PENTACHLORBIPHENYL C12H5Cl5 326.44Clc(ccc1Cl)cc1c(cc2Cl)c(Cl)cc2Cl 38380-02-8 2,2`,3,4,5`-PENTACHLORBIPHENYL C12H5Cl5 326.44Clc(ccc1Cl)cc1c(ccc2Cl)c(Cl)c2Cl 18259-05-7 2,3,4,5,6-PENTACHLORBIPHENYL C12H5Cl5 326.44Clc2c(Cl)c(Cl)c(c1ccccc1)c(Cl)c2Cl 47221-31-8 2-dodecylbenzenesulfonic acid C18H30O3S 326.50CCCCCCCCCCCCc1ccccc1S(O)(=O)=O 18281-04-4 NONADECANSAEUREETHYLESTER C21H42O2 326.56CCCCCCCCCCCCCCCCCCC(OCC)=O 1120-28-1 EICOSANSAEUREMETHYLESTER C21H42O2 326.56CCCCCCCCCCCCCCCCCCCC(OC)=O 661-19-8 1-DOCOSANOL C22H46O 326.60OCCCCCCCCCCCCCCCCCCCCCC 1420-04-8 5-chloro-n-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide C13H8Cl2N2O4 327.12Clc(ccc2O)cc2C(=O)Nc1ccc(cc1Cl)N(=O)=O 1649-18-9 1-(4-fluorophenyl)-4-(4-pyridin-2-ylpiperazin-1-yl)butan-1-one C19H22FN3O Fc2ccc(C(CCCN3CCN(CC3)c1ccccn1)=O)cc2327.40 55334-42-4 1,2-DIBROMODODECANE C12H24Br2 328.13 CCCCCCCCCCC(Br)CBr 36894-69-6 labetalol C19H24N2O3 CC(NCC(O)c(ccc2O)cc2C(=O)N)CCc1ccccc1328.41 191-68-4 DIBENZO(G,P)CHRYSEN C26H16 c(ccc2c5c4ccccc64)cc2c1ccccc1c5c3ccccc63328.41 147-82-0 2,4,6-TRIBROMBENZOLAMIN C6H4Br3N 329.82 Brc(cc1Br)cc(Br)c1N 624-38-4 1,4-DIJODBENZOL C6H4I2 329.91 Ic1ccc(I)cc1 36734-19-7 3-(3,5-dichlorophenyl)-2,4-dioxo-n-propan-2-ylimidazolidine-1-carboxamideC13H13Cl2N3O3CC(C)NC(=O)N(CC1=O)C(=O)N1c(cc2Cl)cc(Cl)c2330.17 121-75-5 ((DIMETHOXYPHOSPHINOTHIOYL)THIO)BUTANDISAEUREDIETHYLESTERC10H19O6PS2 330.36CCOC(CC(C(OCC)=O)SP(OC)(OC)=S)=O 2445-07-0 urbacid C7H15AsN2S4 330.39CN(C)c(s1)s[As]1(C)SC(=S)N(C)C 1530-12-7 9,9-BI-9H-FLUOREN C26H18 c(ccc1c2ccccc2C5C6c3ccccc3c4ccccc64)cc51330.42 33741-19-4 8b,16b-dihydrodibenzo[g,p]chrysenemixtureofcis C26H18 c(ccc2c1ccccc1C5c4ccccc4c3ccccc63)cc2C65330.42 1499-10-1 9,10-DIPHENYLANTHRACEN C26H18 330.42c(cc1)ccc1c(c4ccccc54)c3ccccc3c5c2ccccc2

Page 112 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 4445-07-2 OCTADECYLBENZOL C24H42 330.59CCCCCCCCCCCCCCCCCCc1ccccc1 54-31-9 4-chloro-n-(2-furylmethyl)-5-sulfamoylanthranilicacid C12H11ClN2O5S OC(=O)c2cc(c(Cl)cc2NCc1occc1)S(=O)(=O)N330.75 118-79-6 2,4,6-TRIBROMPHENOL C6H3Br3O 330.80 Brc(cc1Br)cc(Br)c1O 162707-16-6 (2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol C17H12Cl2N2O 331.20OC(c1cncnc1)(c(cc2)ccc2Cl)c3ccccc3Cl 17418-58-5 PHENOXAMIN C20H13NO4 Oc(cc3Oc1ccccc1)c4c(C(=O)c2ccccc2C4=O)c3N331.32 36322-90-4 4-HYDROXY-2-METHYL-N-2-PYRIDINYL-2H-1,2-BENZOTHIAZIN-3-CARBOXAMID-1,1-DIOXIDC15H13N3O4S OC(c2ccccc2S3(=O)=O)=C(C(=O)Nc1ccccn1)N3C331.35 558-13-4 TETRABROMMETHAN CBr4 331.65 BrC(Br)(Br)Br 22686-44-8 2,2'-diselenobis-2-methylpropionicacid C8H14O4Se2 332.12CC(C)([Se][Se]C(C)(C)C(O)=O)C(O)=O 3302-52-1 benzo(rst)pentaphene-5,8-dione C24H12O2 O=C5c4ccc6c3c4c(c1ccccc51)ccc3c2ccccc2C6=O332.35 82558-50-7 isoxaben C18H24N2O4 CCC(C)(CC)c1cc(on1)NC(c2c(OC)cccc2OC)=O332.40 50-22-6 (11BETA)-11,21-DIHYDROXY-4-PREGNEN-3,20-DION C20H28O4OC4C3C2(C)CCC(=O)C=C2CCC3C1CCC(C1C4)C(CO)=O332.44 632-51-9 TETRAPHENYLETHEN C26H20 c(cc1)ccc1C(c4ccccc4)=C(c3ccccc3)c2ccccc2332.44 55283-68-6 n-ethyl-n-(2-methylprop-2-enyl)-2,6-dinitro-4-(trifluoromethyl)anilineC13H14F3N3O4CCN(CC(C)=C)c1c(cc(C(F)(F)F)cc1N(=O)=O)N(=O)=O333.26 1464-43-3 3,3'-diselenobisalanine C6H12N2O4Se2 334.10NC(C[Se][Se]CC([NH3+])C([O-])=O)C(O)=O 434-90-2 PERFLUORBIPHENYL C12F10 334.11Fc1c(F)c(F)c(c(F)c1F)c(c(F)c2F)c(F)c(F)c2F 84-75-3 1,2-BENZOLDICARBONSAEUREDIHEXYLESTER C20H30O4 334.45CCCCCCOC(=O)c1ccccc1C(OCCCCCC)=O 632-50-8 1,1,2,2-TETRAPHENYLETHAN C26H22 334.46c(cc1)ccc1C(C(c4ccccc4)c3ccccc3)c2ccccc2 2294-94-2 1,1,1,2-TETRAPHENYLETHAN C26H22 334.46C(c4ccccc4)C(c3ccccc3)(c2ccccc2)c1ccccc1 1861-40-1 benfluralin C13H16F3N3O4CCCCN(CC)c1c(cc(C(F)(F)F)cc1N(=O)=O)N(=O)=O335.28 1582-09-8 TRIFLURALIN C13H16F3N3O4CCCN(CCC)c1c(cc(C(F)(F)F)cc1N(=O)=O)N(=O)=O335.28 1100-10-3 BENZENEAMINE,4-NITRO-N-(4-NITROPHENYL)-N-PHENYL-C18H13N3O4O=N(=O)c(cc2)ccc2N(c1ccccc1)c3ccc(cc3)N(=O)=O335.32 90936-47-3 1-(3,5-dichlorophenoxy)silatrane C12H15Cl2NO4Si 336.24Clc1cc(O[Si]2(OCC3)OCCN3CCO2)cc(Cl)c1 1048-08-4 TETRAPHENYLSILAN C24H20Si 336.50c(cc1)ccc1[Si](c4ccccc4)(c3ccccc3)c2ccccc2 10192-32-2 1-TETRACOSENE C24H48 336.64CCCCCCCCCCCCCCCCCCCCCCC=C 76824-35-6 3-(((2-(AMINOIMINOMETHYL)AMINO)-4-THIAZOYL)METHYL)THIO)-N-(AMINOSULFONIL)PROPANIC8H15N7O2S3 NC(N)=Nc(sc1)nc1CSCCC(N)=NS(=O)(=O)N337.45 355-42-0 TETRADECAFLUORHEXAN C6F14 FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F338.04 112-86-7 (13Z)-13-DOCOSENSAEURE C22H42O2 338.57CCCCCCCCC=CCCCCCCCCCCCC(O)=O 646-31-1 TETRACOSAN C24H50 338.66CCCCCCCCCCCCCCCCCCCCCCCC 12758-40-6 propagermanium C6H10Ge2O7 339.42 0.00 2338-37-6 darvon C22H29NO2 CN(C)CC(C)C(OC(CC)=O)(Cc1ccccc1)c2ccccc2339.47 82-66-6 diphenadione C23H16O3 O=C(C4C(=O)c3ccccc3C4=O)C(c2ccccc2)c1ccccc1340.37 112-85-6 DOCOSANSAEURE C22H44O2 340.59CCCCCCCCCCCCCCCCCCCCCC(O)=O 123-95-5 OCTADECANSAEUREBUTYLESTER C22H44O2 340.59CCCCCCCCCCCCCCCCCC(OCCCC)=O 41992-23-8 spirogermanium C17H36GeN2 CN(C)CCCN(CC1)CC1(CC2)CC[Ge]2(CC)CC341.12 60207-90-1 propiconazole C15H17Cl2N3O2 342.22CCCC(CO2)OC2(Cn1cncn1)c3ccc(Cl)cc3Cl 57-50-1 SUCROSE C12H22O11 OCC2OC(C(O)C(O)C2O)OC1(CO)OC(CO)C(O)C1O342.30 2424-92-2 1,20-EICOSANDISAEURE C20H38O4 OC(CCCCCCCCCCCCCCCCCCC(O)=O)=O342.52 34880-53-0 2,2,2-TRINITRO-N-(2,2,2-TRINITROETHYL)-ETHANAMIN C4H5N7O12O=N(=O)C(CNCC(N(=O)=O)(N(=O)=O)N(=O)=O)(N(=O)=O)N(=O)=O343.12 79-28-7 TETRABROMETHEN C2Br4 343.64 BrC(Br)=C(Br)Br 706-78-5 OCTACHLORCYCLOPENTEN C5Cl8 343.68ClC1(Cl)C(Cl)(Cl)C(Cl)=C(Cl)C1(Cl)Cl 2554-06-5 cyclotetrasiloxane,2,4,6,8-tetraethenyl-2,4,6,8-tetramethyl- C12H24O4Si4C[Si]1(O[Si](C)(O[Si](C)(O[Si](C)(O1)C=C)C=C)C=C)C=C344.66 4726-14-1 4-(methylsulfonyl)-2,6-dinitro-n,n-dipropylbenzenamine C13H19N3O6SCCCN(CCC)c1c(N(=O)=O)cc(cc1N(=O)=O)S(C)(=O)=O345.37 2642-71-9 DITHIOPHOSPHORSAEURE-O-DIETHYL-S-((4-OXO-1,2,3-BENNZOTRIAZIN-3(4H)-YL)METHYL)ESTC12H16N3O3PS2 345.38CCOP(OCC)(SCN2N=Nc1ccccc1C2=O)=S 79-27-6 1,1,2,2-TETRABROMETHAN C2H2Br4 345.65 BrC(Br)C(Br)Br 72-43-5 METHOXYCHLOR C16H15Cl3O2 345.65ClC(Cl)(Cl)C(c(cc2)ccc2OC)c(cc1)ccc1OC 83801-60-9 1-(3-bromophenoxy)silatrane C12H16BrNO4Si 346.25Brc(ccc1)cc1O[Si]2(OCC3)OCCN3CCO2 86811-82-7 1-(4-bromophenoxy)silatrane C12H16BrNO4Si 346.25Brc(cc1)ccc1O[Si]2(OCC3)OCCN3CCO2 21829-25-4 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINDICARBONSAEUREDIMETHYLESTEC17H18N2O6COC(=O)C2=C(C)NC(C)=C(C2c1ccccc1N(=O)=O)C(OC)=O346.34 1323-65-5 DINONYLPHENOL C24H42O 346.59CCCCCCCCCc1cc(O)ccc1CCCCCCCCC 26399-36-0 N-(CYCLOPROPYLMETHYL)-2,6-DINITRO-N-PROPYL-4-(TRIFLUORMETHYL)BENZOLAMINC14H16F3N3O4CCCN(CC1CC1)c2c(cc(C(F)(F)F)cc2N(=O)=O)N(=O)=O347.29 16087-30-2 1-butanone,3,3'-(1,2-ethanediyldinitrilo)bis[1-ph C22H24N2O2CC(CC(=O)c2ccccc2)=NCCN=C(C)CC(=O)c1ccccc1348.44 3180-81-2 DISPERSERED13 C16H17ClN4O3 OCCN(CC)c1ccc(N=Nc2ccc(cc2Cl)N(=O)=O)cc1348.79 355-02-2 PERFLUORMETHYLCYCLOHEXAN C7F14 FC(F)(F)C(F)(C(F)(F)C1(F)F)C(F)(F)C(F)(F)C1(F)F350.05 190-39-6 PHENANTHRO-(1,10,9,8-OPQRA)-PERYLEN C28H14 c(cc1cc3cccc8c53)cc7c1c5c6c2c7cccc2cc4cccc8c64350.41 26002-80-2 phenothrin C23H26O3 CC1(C)C(C1C(OCc3cc(Oc2ccccc2)ccc3)=O)C=C(C)C350.45 39475-55-3 diethoxy-sulfanylidene-(3,5,6-trichloropyridin-2-yl)oxyphosphoraneC9H11Cl3NO3PS 350.59CCOP(OCC)(Oc(nc1Cl)c(Cl)cc1Cl)=S 126-07-8 GRISEOFULVIN C18H19ClO5COc3cc(OC)c(C1=O)c(CC21C(OC)=CC(CC2C)=O)c3Cl350.80 146-54-3 triflupromazine C18H19F3N2S 352.42CN(C)CCCn3c2cc(C(F)(F)F)ccc2sc1ccccc31 363-24-6 PROSTAGLANDIN_E2 C20H32O5CCCCCC(O)C=CC1C(CC=CCCCC(O)=O)C(CC1O)=O352.47 1120-34-9 CIS-13-DOCOSENSAEURE-METHYLESTER C23H44O2 CCCCCCCCC=CCCCCCCCCCCCC(OC)=O352.60 629-99-2 PENTACOSAN C25H52 352.68CCCCCCCCCCCCCCCCCCCCCCCCC 78587-05-0 (4s)-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-1,3-thiazolidine-3-carboxamideC17H21ClN2O2SClc2ccc(cc2)C3SC(=O)N(C3C)C(=O)NC1CCCCC1352.88

Page 113 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 1116-76-3 N,N-DIOCTYL-1-OCTANAMIN C24H51N 353.67CCCCCCCCN(CCCCCCCC)CCCCCCCC 20532-03-0 9,9`-BIPHENANTHREN C28H18 c(ccc1c2ccccc2c5c6c4ccccc4c3ccccc3c6)cc1c5354.44 1055-23-8 9,9`-BIANTHRYL C28H18 c(ccc51)cc1cc2ccccc2c5c6c3ccccc3cc4ccccc64354.44 745-65-3 prostaglandine-e1 C20H34O5 CCCCCC(O)C=CC1C(CCCCCCC(O)=O)C(CC1O)=O354.48 50-29-3 1,1-DI-(4-CHLORPHENYL)-2,2,2-TRICHLORETHAN C14H9Cl5 354.49ClC(Cl)(Cl)C(c(cc2)ccc2Cl)c(cc1)ccc1Cl 33245-39-5 n-(2-chloroethyl)-2,6-dinitro-n-propyl-4-(trifluoromethyl)benzenamineC12H13ClF3N3O4CCCN(CCCl)c1c(cc(C(F)(F)F)cc1N(=O)=O)N(=O)=O355.70 38194-50-2 sulindac C20H17FO3S OC(=O)Cc1c2cc(F)ccc2c(c1C)=Cc(cc3)ccc3S(C)=O356.41 111-03-5 (9Z)-9-OCTADECENSAEURE-2,3-DIHYDROXYPROPYLESTERC21H40O4 CCCCCCCCC=CCCCCCCCC(OCC(O)CO)=O356.54 34454-97-2 n-(2-hydroxymethyl)-n-methyl-nonafluoro-1-butanesulfonamideC7H8F9NO3S FC(F)(F)C(F)(F)C(F)(F)C(F)(F)S(=O)(=O)N(C)CCO357.20 3634-47-7 TETRAPENTYLGERMANIUM C20H44Ge 357.21CCCCC[Ge](CCCCC)(CCCCC)CCCCC 116-45-0 4-amino-n-(5-bromo-4,6-dimethylpyrimidin-2-yl)benzenesulfonamideC12H13BrN4O2S 357.23Nc1ccc(cc1)S(=O)(=O)Nc(nc2C)nc(C)c2Br 53-86-1 1-(4-CHLORBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-ESSIGSAEUREC19H16ClNO4COc(ccc1n(c2C)C(c(cc3)ccc3Cl)=O)cc1c2CC(O)=O357.79 53-03-2 17,21-DIHYDROXYPREGNA-1,4-DIEN-3,11,20-TRION C21H26O5OCC(C1(O)CCC4C3CCC2=CC(=O)C=CC2(C)C3C(CC41C)=O)=O358.43 14187-32-7 2,3,11,12-DIBENZO-1,4,7,10,13,16-HEXAOXACYCLOOCT C20H24O6 360.40O3CCOc1ccccc1OCCOCCOc2ccccc2OCC3 50-24-8 (11BETA)-11,17,21-TRIHYDROXYPREGNA-1,4-DIEN-3,20-DIONC21H28O5OC(CC41C)C3C2(C)C=CC(=O)C=C2CCC3C4CCC1(O)C(CO)=O360.45 35065-27-1 2,2`,4,4`,5,5`-HEXACHLORBIPHENYL C12H4Cl6 360.88Clc2cc(Cl)c(cc2Cl)c(cc1Cl)c(Cl)cc1Cl 38380-07-3 2,2`,3,3`,4,4`-HEXACHLORBIPHENYL C12H4Cl6 360.88Clc2ccc(c(Cl)c2Cl)c(ccc1Cl)c(Cl)c1Cl 5486-03-3 ethyl 6,7-bis(2-methylpropoxy)-4-oxo-1h-quinoline-3-carboxylateC20H27NO5CC(C)COc1cc2C(=O)C(C(OCC)=O)=CNc2cc1OCC(C)C361.43 50-23-7 HYDROCORTISONE C21H30O5OC(CC41C)C3C2(C)CCC(=O)C=C2CCC3C4CCC1(O)C(CO)=O362.46 21888-98-2 dexetimide C23H26N2O2O=C(CCC4(C(CC3)CCN3Cc2ccccc2)c1ccccc1)NC4=O362.47 3648-21-3 PHTHALSAEUREDIHEPTHYLESTER C22H34O4 CCCCCCCOC(=O)c1ccccc1C(OCCCCCCC)=O362.51 375-85-9 TRIDECAFLUORHEPTANSAEURE C7HF13O2 FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(O)=O364.06 74222-97-2 sulfometuronmethyl C15H16N4O5SCOC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc(nc2C)nc(C)c2364.38 1806-34-4 1,4-BIS-(5-PHENYL-1,3-OXAZOL-2-YL)-BENZOL C24H16N2O2 c(cc1)ccc1c3oc(nc3)c4ccc(cc4)c(nc5)oc5c2ccccc2364.40 18835-33-1 1-HEXACOSENE C26H52 364.69CCCCCCCCCCCCCCCCCCCCCCCCC=C 13997-19-8 methyl 6-butyl-4-oxo-7-(phenylmethoxy)-1h-quinoline-3-carboxylateC22H23NO4CCCCc2cc3C(=O)C(C(OC)=O)=CNc3cc2OCc1ccccc1365.42 2104-96-3 BROMOPHOS-METHYL C8H8BrCl2O3PS 366.00COP(OC)(Oc(cc1Cl)c(Cl)cc1Br)=S 37910-77-3 ethyl-erucate C24H46O2 CCCCCCCCC=CCCCCCCCCCCCC(OCC)=O366.62 630-01-3 HEXACOSAN C26H54 366.71CCCCCCCCCCCCCCCCCCCCCCCCCC 78-30-8 TRI-O-CRESYLPHOSPHAT C21H21O4P Cc1ccccc1OP(Oc3ccccc3C)(Oc2ccccc2C)=O368.36 15845-47-3 (1e,6e)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dioneC21H20O6 COc2cc(ccc2O)C=CC(CC(=O)C=Cc(ccc1O)cc1OC)=O368.38 5908-87-2 DOCOSANSAEUREETHYLESTER C24H48O2 CCCCCCCCCCCCCCCCCCCCCC(OCC)=O368.64 747-90-0 cholesta-3,5-diene C27H44CC(C)CCCC(C)C1CCC3C4CC=C2C=CCCC2(C)C4CCC31C368.64 123-79-5 HEXANDISAEUREDIOCTYLESTER C22H42O4 CCCCCCCCOC(CCCCC(OCCCCCCCC)=O)=O370.57 103-23-1 DI-(2-ETHYLHEXYL)-ADIPAT C22H42O4 CCCCC(CC)COC(CCCCC(OCC(CC)CCCC)=O)=O370.57 50-52-2 aldazine C21H26N2S2 370.58CN1CCCCC1CCn4c3cc(SC)ccc3sc2ccccc42 4731-53-7 TRIOCTYLPHOSPHIN C24H51P 370.64CCCCCCCCP(CCCCCCCC)CCCCCCCC 541-02-6 DECAMETHYLCYCLOPENTASILOXAN C10H30O5Si5C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1370.77 34882-73-0 2,2,2,2`,2`,2`-HEXANITRO-N-NITROSODIETHYLAMIN C4H4N8O13O=NN(CC(N(=O)=O)(N(=O)=O)N(=O)=O)CC(N(=O)=O)(N(=O)=O)N(=O)=O372.12 23257-62-7 N,N-BIS-(3-PHENOXY-2-HYDROXYPROPYL)-BUTYLAMIN C22H31NO4 CCCCN(CC(O)COc2ccccc2)CC(O)COc1ccccc1373.49 41198-08-7 o-ethyl-o'-4-bromo-2-chlorophenyl-s-propylphosphorothioate0C11H15BrClO3PS 373.63CCCSP(OCC)(Oc1ccc(Br)cc1Cl)=O 6263-74-7 bis(2,2,2-trinitroethoxy)-methane C5H6N6O14O=N(=O)C(COCOCC(N(=O)=O)(N(=O)=O)N(=O)=O)(N(=O)=O)N(=O)=O374.13 59358-73-5 1,1-(1,1-BICYCLOOCTYL)-1,1-DIYLBISBENZOL C28H38 C(CCC4)CCCC4(C3(CCCCCCC3)c1ccccc1)c2ccccc2374.60 36360-34-6 N,N-BIS(2-METHOXYPHENYL)-1,4-BENZOLDICARBOXAMIDC22H20N2O4 COc3ccccc3NC(c1ccc(cc1)C(=O)Nc2ccccc2OC)=O376.41 6957-81-9 N,N`-BIS(M-METHOXYPHENYL)TEREPHTALAMID C22H20N2O4COc3cc(ccc3)NC(c1ccc(cc1)C(=O)Nc(ccc2)cc2OC)=O376.41 7144-15-2 N,N`-BIS(P-METHOXYPHENYL)TEREPHTHALAMID C22H20N2O4COc2ccc(cc2)NC(c1ccc(cc1)C(=O)Nc(cc3)ccc3OC)=O376.41 75847-73-3 1-[n-[1-(ethoxycarbonyl)-3-phenylpropyl]-l-alanyl]-l-proline C20H28N2O5CCOC(C(CCc2ccccc2)NC(C)C(=O)N1CCCC1C(O)=O)=O376.45 191-13-9 PYRANTHREN C30H16 c(ccc51)cc1cc3ccc7cc8c4c6c7c3c5cc6ccc4cc2ccccc82376.45 165450-17-9 (3r)-3-(3,3-dimethylbutylamino)-4-[[(2r)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoicC20H30N2O5CC(C)(C)CCNC(CC(O)=O)C(=O)NC(Cc1ccccc1)C(OC)=O378.46 acid 593-49-7 HEPTACOSAN C27H56 380.74CCCCCCCCCCCCCCCCCCCCCCCCCCC 18281-07-7 TRICOSANSAEUREETHYLESTER C25H50O2 CCCCCCCCCCCCCCCCCCCCCCC(OCC)=O382.67 3263-31-8 vat-5-orange C20H16O4S2CCOc(ccc1C3=O)cc1SC3=C4Sc2cc(OCC)ccc2C4=O384.47 141-63-9 DODECAMETHYLPENTASILOXAN C12H36O4Si5C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C384.84 57-88-5 (3BETA)-CHOLEST-5-EN-3-OL C27H46OCC(C)CCCC(C)C1CCC4C3CC=C2CC(O)CCC2(C)C3CCC41C386.66 3229-00-3 1,3-DIBROM-2,2-BIS(BROMMETHYL)PROPAN C5H8Br4 387.73 BrCC(CBr)(CBr)CBr 112-04-9 trichloro-octadecylsilane C18H37Cl3Si 387.93CCCCCCCCCCCCCCCCCC[Si](Cl)(Cl)Cl 335-57-9 HEXADECAFLUORHEPTAN C7F16 FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F388.05 19836-28-3 n-nitrobis-(2,2,2-trinitroethyl)amine O=N(=O)C(CN(CC(N(=O)=O)(N(=O)=O)N(=O)=O)N(=O)=O)(N(=O)=O)N(=O)=OC4H4N8O14 388.12 130-85-8 3,3'-dihydroxy-4,4'-methylenedi-2-naphthoicacid C23H16O6OC(=O)c4cc2ccccc2c(Cc(c3O)c1ccccc1cc3C(O)=O)c4O388.37 57441-02-8 17betaestradiol3tbutyldimethylsilyloxy C24H40O2SiOC1CCC3C2CCC(=C)C(C2CCC31C)=CC=CO[Si](C)(C)C(C)(C)C388.66 6422-86-2 1,4-BENZENEDICARBOXYLICACID,BIS(2-ETHYLHEXYL)ESTERC24H38O4 CCCCC(CC)COC(=O)c1ccccc1C(OCC(CC)CCCC)=O390.56 117-81-7 BIS-(2-ETHYLHEXYL)-PHTHALAT C24H38O4 CCCCC(CC)COC(=O)c1ccccc1C(OCC(CC)CCCC)=O390.56

Page 114 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 27554-26-3 DIISOOCTYLPHTHALAT C24H38O4 CC(C)CCCCCOC(=O)c1ccccc1C(OCCCCCC(C)C)=O390.56 117-84-0 1,2-BENZOLDICARBONSAEUREDIOCTYLESTER C24H38O4 CCCCCCCCOC(=O)c1ccccc1C(OCCCCCCCC)=O390.56 4654-26-6 TEREPHTHALSAEUREDIOCTYLESTER C24H38O4 CCCCCCCCOC(=O)c1ccccc1C(OCCCCCCCC)=O390.56 19295-81-9 1,2-BENZENEDICARBOXYLICACID,HEPTYL,NONYLESTER C24H38O4 CCCCCCCOC(=O)c1ccccc1C(OCCCCCCCCC)=O390.56 35112-74-4 2,13-DIOXA-7,8-DITHIA-3,12-DISILATETRADECANE,3,3,12,12-TETRAMETHOXY-C12H30O6S2Si2 CO[Si](OC)(OC)CCCSSCCC[Si](OC)(OC)OC390.67 52645-53-1 3-(2,2-DICHLOROVINYL)-2,2-DIMETHYLCYCLOPROPANECAC21H20Cl2O3CC1(C)C(C1C(OCc3cc(Oc2ccccc2)ccc3)=O)C=C(Cl)Cl391.29 13450-92-5 TETRABROMGERMANIUM Br4Ge 392.26 Br[Ge](Br)(Br)Br 50-02-2 (11BETA,16ALPHA)-9-FLUOR-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIEN-3,20-DIONC22H29FO5CC(CC4C3CCC1=CC(=O)C=CC1(C)C3(F)C(O)CC42C)C2(O)C(CO)=O392.46 18835-34-2 1-OCTACOSENE C28H56 CCCCCCCCCCCCCCCCCCCCCCCCCCC=C392.75 5462-29-3 threneredvioletrh C18H10Cl2O2S2Clc(cc1C)cc3c1SC(C3=O)=C(Sc2c4cc(Cl)cc2C)C4=O393.31 2379-74-0 helindone-pink-cn C18H10Cl2O2S2Clc(cc1C)cc(SC3=C4Sc(cc(Cl)cc2C)c2C4=O)c1C3=O393.31 3088-05-9 N,N-BIS-(2-HYDROXY-3-PHENOXYPROPYL)-ANILIN C24H27NO4 OC(COc2ccccc2)CN(CC(O)COc3ccccc3)c1ccccc1393.48 636-28-2 1,2,4,5-TETRABROMBENZOL C6H2Br4 393.70 Brc1cc(Br)c(Br)cc1Br 75-47-8 TRIIODMETHAN CHI3 393.73 IC(I)I 630-02-4 OCTACOSAN C28H58 CCCCCCCCCCCCCCCCCCCCCCCCCCCC394.76 52712-05-7 2,2,3,4,5,5,6-HEPTACHLOR-1,1-BIPHENYL C12H3Cl7 395.33Clc(ccc1Cl)cc1c(c(Cl)c2Cl)c(Cl)c(Cl)c2Cl 57-87-4 ERGOSTEROL C28H44OCC(C)C(C)C=CC(C)C1CCC3C(C4CCC31C)=CC=C2CC(O)CCC42C396.65 83-73-8 5,7-DIIOD-8-HYDROXYCHINOLIN C9H5I2NO 396.95 Ic2cc(I)c1cccnc1c2O 56038-13-2 (2r,3r,4r,5r,6r)-2-[(2r,3s,4s,5s)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diolC12H19Cl3O8OCC2OC(C(O)C(O)C2Cl)OC1(CCl)OC(CCl)C(O)C1O397.64 190-26-1 OVALEN C32H14c(c5)c4ccc7cc(ccc2ccc1ccc3cc6ccc5c%10c86)c9c2c1c3c8c9c7c%104398.46 393-02-2 1,2,3,4-TETRAKIS-(TRIFLUORMETHYL)-CYCLOTETRAPHOSPHINC4F12P4 FC(F)(F)p2p1(C(F)(F)F)p(C(F)(F)F)p21C(F)(F)F399.92 1174-72-7 KIESELSAEURE(H4SIO4)TETRAPHENYLESTER C24H20O4Si O([Si](Oc4ccccc4)(Oc3ccccc3)Oc1ccccc1)c2ccccc2400.50 177-49-1 tetracyclotetramethylenecyclcotetrasiloxane C16H32O4Si4C(CC[Si]2(O[Si]53CCCC3)O[Si]1(CCCC1)O[Si]4(CCCC4)O5)C2400.77 307-99-3 1,8-DIHYDROPERFLUOROCTAN C8H2F16 FC(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)F402.08 94-28-0 2-ETHYLHEXANSAEURE-1,2-ETHANDIYLBIS(OXY-2,1-ETHANDIYL)ESTERC22H42O6 CCCCC(CC)C(OCCOCCOCCOC(C(CC)CCCC)=O)=O402.57 58-39-9 4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-piperazineethanol C21H26ClN3OSOCCN1CCN(CC1)CCCn4c3cc(Cl)ccc3sc2ccccc42403.97 75330-75-5 (2S)-2-METHYLBUTANSAEURE-(1S,3R,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-3,7-DIMETHYL-8C24H36O5CCC(C)C(OC2C(C1CCC(C3)OC(CC3O)=O)C(=CCC2C)C=CC1C)=O404.54 128-70-1 8,16-PYRANTHENDION C30H14O2O=C8c6c2ccccc2cc(ccc74)c6c4c3c5c(ccc83)cc1ccccc1c5C7=O406.43 85956-22-5 pravastatin C23H34O6CCC(C)C(OC2CC(O)C=C(C2C1CCC(C3)OC(CC3O)=O)C=CC1C)=O406.51 85668-74-2 3,4-DIETHYL-3,4-BIS(4-TERT.-BUTYLPHENYL)-HEXAN C30H46CCC(C)C(C(CC)(CC)c(cc2)ccc2C(C)(C)C)c(cc1)ccc1C(C)(C)C406.69 70-30-4 HEXACHLOROPHEN C13H6Cl6O2 Clc1cc(Cl)c(Cl)c(Cc(c2O)c(Cl)c(Cl)cc2Cl)c1O406.91 115-29-7 6,7,8,9,10,10-HEXACHLOR-1,5,5A,6,9,9A-HEXAHYDRO-6,9-METHANO-2,4,3-BENZODIOXATHIEC9H6Cl6O3S ClC1(Cl)C2(Cl)C3COS(OCC3C1(Cl)C(Cl)=C2Cl)=O406.93 117-89-5 TRIFLUORPERAZIN C21H24F3N3SCN1CCN(CC1)CCCn4c3cc(C(F)(F)F)ccc3sc2ccccc42407.50 105024-66-6 silafluofen C25H29FO2SiCCOc2ccc([Si](C)(C)CCCc(ccc3F)cc3Oc1ccccc1)cc2408.58 546-45-2 cyclotrisiloxane,2,4,6-trimethyl-2,4,6-triphenyl- C21H24O3Si3C[Si](O4)(O[Si](C)(O[Si]4(C)c3ccccc3)c1ccccc1)c2ccccc2408.67 630-03-5 NONACOSAN C29H60 CCCCCCCCCCCCCCCCCCCCCCCCCCCCC408.79 83-48-7 (3BETA,22E)-STIGMASTA-5,22-DIEN-3-OL C29H48OCCC(C(C)C)C=CC(C)C(CCC1C3CC=C2CC(O)CCC42C)C1(C)CCC43412.69 56209-45-1 diltiazem C22H26N2O4SCN(C)CCN(c2ccccc2SC3c(cc1)ccc1OC)C(C3OC(C)=O)=O414.52 83-46-5 (3BETA)-STIGMAST-5-EN-3-OL C29H50OCCC(C(C)C)CCC(C)C1CCC4C3CC=C2CC(O)CCC2(C)C3CCC41C414.71 321-55-1 bis(2-chloroethyl) (3-chloro-4-methyl-2-oxochromen-7-yl) phosphateC14H14Cl3O6PClCCOP(OCCCl)(Oc(ccc1C(C)=C2Cl)cc1OC2=O)=O415.59 147059-72-1 trovan C20H15F3N4O3NC1C2CN(CC21)c4nc5N(c3ccc(F)cc3F)C=C(C(O)=O)C(c5cc4F)=O416.36 28553-12-0 PHTHALSAEUREDIISONONYLESTER C26H42O4CC(C)CCCCCCOC(=O)c1ccccc1C(OCCCCCCC(C)C)=O418.61 65185-88-8 1,2-BENZENEDICARBOXYLICACID,HEPTYL,UNDECYLESTERC26H42O4 CCCCCCCOC(=O)c1ccccc1C(OCCCCCCCCCCC)=O418.61 111381-90-9 1,2-benzenedicarboxylicacidheptylundecylester C26H42O4 CCCCCCCOC(=O)c1ccccc1C(OCCCCCCCCCCC)=O418.61 84-76-4 PHTHALSAEUREDINONYLESTER C26H42O4 CCCCCCCCCOC(=O)c1ccccc1C(OCCCCCCCCC)=O418.61 335-65-9 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-HEPTADECAFLUOROCTAN C8HF17FC(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F420.07 18435-53-5 1-TRIACONTENE C30H60 CCCCCCCCCCCCCCCCCCCCCCCCCCCCC=C420.80 111-01-3 2,6,10,15,19,23-HEXAMETHYLTETRACOSAN C30H62CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C422.82 638-68-6 TRIACONTAN C30H62 CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC422.82 7688-25-7 1,4-BIS-(DIPHENYLPHOSPHINO)-BUTAN C28H28P2 C(CCP(c3ccccc3)c1ccccc1)CP(c4ccccc4)c2ccccc2426.47 190-93-2 BENZO(RST)PHENANTHRO(1,10,9-CDE)PENTAPHEN C34H18c(ccc71)cc1cc5ccc8c6c5c7ccc6c4ccc3cccc9c3c4c8c2ccccc92426.51 191-79-7 TETRABENZO(DE,HI,OP,ST)PENTACEN C34H18c(cc1ccc3)cc7c2cccc(c2c8c3c71)c9c4c8cccc4c6c5c9cccc5ccc6426.51 59-02-9 (2R)-3,4-DIHYDRO-2,5,7,8-TETRAMETHYL-2-((4R,8R)-4,8,12-TRIMETHYLTRIDECYL)-2H-1-BC29H50O2CC(C)CCCC(C)CCCC(C)CCCC1(C)Oc(c(C)c2C)c(CC1)c(C)c2O430.71 83855-46-3 [cyano-[4-fluoro-3-(phenoxy)phenyl]methyl] 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylateC22H18Cl2FNO3CC1(C)C(C1C(OC(C#N)c(ccc3F)cc3Oc2ccccc2)=O)C=C(Cl)Cl434.29 85668-75-3 1,1-(2,4,5,7-TETRAMETHYLOCTAN-4,5-DIYL)BIS(4-(1,1-DIMETHYLETHYL)BENZOL)C32H50CC(C)CC(C)(C(C)(CC(C)C)c(cc2)ccc2C(C)(C)C)c(cc1)ccc1C(C)(C)C434.74 85668-73-1 4,5-DIETHYL-4,5-BIS(4-TERT.-BUTYLPHENYL)-OCTAN C32H50CCCC(CC)(C(CC)(CCC)c(cc2)ccc2C(C)(C)C)c(cc1)ccc1C(C)(C)C434.74 26644-46-2 n-[2,2,2-trichloro-1-[4-(2,2,2-trichloro-1-formamidoethyl)piperazin-1-yl]ethyl]formamideC10H14Cl6N4O2ClC(Cl)(Cl)C(N1CCN(CC1)C(C(Cl)(Cl)Cl)NC=O)NC=O434.96 307-34-6 OCTADECAFLUOROCTAN C8F18FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F438.06 60-54-8 (2z,4s,4as,5as,6s,12as)-2-(amino-hydroxymethylidene)-4-dimethylamino-6,10,11,12a-tetrahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trioneCN(C)C4C2CC(C3(O)C)C(=C(O)c1c3cccc1O)C(=O)C2(O)C(=O)C(=C(O)N)C4=OC22H24N2O8 444.44 1314-80-3 PHOSPHORSULFID_(P4S10) P4S10 444.55S=P3(S1)SP(SP1(S2)=S)(SP2(S3)=S)=S 540-97-6 DODECAMETHYLCYCLOHEXASILOXAN C12H36O6Si6C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1444.93 89-16-7 diisodecylphthalat C28H46O4CC(C)CCCCCCCOC(=O)c1ccccc1C(OCCCCCCCC(C)C)=O446.67

Page 115 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 84-77-5 1,2-BENZOLDICARBONSAEUREDIDECYLESTER C28H46O4CCCCCCCCCCOC(=O)c1ccccc1C(OCCCCCCCCCC)=O446.67 111381-91-0 1,2-benzenedicarboxylicacidnonylundecylester C28H46O4CCCCCCCCCOC(=O)c1ccccc1C(OCCCCCCCCCCC)=O446.67 26761-40-0 PALATINOL_Z C28H46O4CC(C)CCCCCCCOC(=O)c1ccccc1C(OCCCCCCCC(C)C)=O446.67 65185-89-9 1,2-BENZENEDICARBOXYLICACID,NONYLUNDECYLESTER C28H46O4CCCCCCCCCOC(=O)c1ccccc1C(OCCCCCCCCCCC)=O446.67 14174-09-5 2,3,14,15-DIBENZO-1,4,7,10,13,16,19,22-OCTAOXACY C24H32O8O1c3c(OCCOCCOCCOc2ccccc2OCCOCCOCC1)cccc3448.51 20062-22-0 2,2`,4,4`6,6`-HEXANITROSTILBEN O=N(=O)c(cc1N(=O)=O)cc(c1C=Cc2c(cc(cc2N(=O)=O)N(=O)=O)N(=O)=O)N(=O)=OC14H6N6O12 450.23 544-85-4 DOTRIACONTAN C32H66 CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC450.87 116-71-2 DIBENZANTHRON C34H16O2O=C9c5ccc7c6c5c(c2ccccc92)ccc6c4ccc(c1ccccc81)c3c4c7ccc3C8=O456.49 107-52-8 TETRADECAMETHYLHEXASILOXAN C14H42O5Si6C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C459.00 3268-87-9 OCTACHLORDIBENZO(B,E)(1,4)DIOXIN C12Cl8O2 Clc2c(Cl)c1Oc(c(Cl)c3Cl)c(Oc1c(Cl)c2Cl)c(Cl)c3Cl459.75 60433-12-7 TRANS-OCTADECAFLUORDECAHYDRONAPHTHALIN C10F18FC2(F)C(F)(F)C(F)(C(F)(F)C1(F)F)C(F)(C(F)(F)C2(F)F)C(F)(F)C1(F)F462.08 306-94-5 PERFLUORDECALIN C10F18FC1(F)C(F)(F)C(F)(C(F)(F)C2(F)F)C(F)(C(F)(F)C2(F)F)C(F)(F)C1(F)F462.08 85668-72-0 4,5-DIPROPYL-4,5-BIS(4-TERT.-BUTYLPHENYL)-OCTAN C34H54CCCC(CCC)(C(CCC)(CCC)c(cc2)ccc2C(C)(C)C)c(cc1)ccc1C(C)(C)C462.80 17912-87-7 5,7-dihydroxy-3-[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2-(3,4,5-trihydroxyphenyl)chromen-4-oneC21H20O12CC4OC(C(O)C(O)C4O)OC3=C(Oc(cc(O)cc1O)c1C3=O)c(cc2O)cc(O)c2O464.38 14685-29-1 tetrabu-tetrame-tetroxatetrasilocane C20H48O4Si4CCCC[Si]1(C)O[Si](C)(CCCC)O[Si](C)(CCCC)O[Si](C)(CCCC)O1464.94 538-23-8 OCTANSAEURE-1,2,3-PROPANETRIYLESTER C27H50O6CCCCCCCC(OC(COC(CCCCCCC)=O)COC(CCCCCCC)=O)=O470.68 50679-08-8 ALPHA-(4-(1,1-DIMETHYLETHYL)PHENYL)-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINBUTANOLC32H41NO2OC(CCCN4CCC(CC4)C(O)(c2ccccc2)c1ccccc1)c3ccc(C(C)(C)C)cc3471.68 3648-20-2 DIUNDECYLPHTHALAT C30H50O4CCCCCCCCCCCOC(=O)c1ccccc1C(OCCCCCCCCCCC)=O474.72 56706-10-6 3,14-DIOXA-8,9-DITHIA-4,13-DISILAHEXADECANE,4,4,13,13-TETRAETHOXY-C18H42O6S2Si2CCO[Si](OCC)(OCC)CCCSSCCC[Si](OCC)(OCC)OCC474.83 7220-97-5 (4s,4as,5as,6s,12as)-2-(amino-hydroxymethylidene)-7-chloro-4-dimethylamino-6,10,11,12a-tetrahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trioneCN(C)C4C2CC3C(=C(O)c(c(O)ccc1Cl)c1C3(O)C)C(=O)C2(O)C(=O)C(=C(O)N)C4=OC22H23ClN2O8 478.88 22736-20-5 HEXAKIS-(TRIFLUORMETHYL)-TETRACYCLO-(2.2.0.0(2,6).0(3,5))-HEXANFC(F)(F)C1(C2(C(F)(F)F)C3(C(F)(F)F)C42C(F)(F)F)C3(C(F)(F)F)C41C(F)(F)FC12F18 486.10 18909-18-7 1-DIPHENYLMETHYLEN-4-TRIPHENYLMETHYL-2,5-CYCLOHEXADIENC38H30c(cc4)ccc4C(c5ccccc5)(c3ccccc3)C6C=CC(=C(c2ccccc2)c1ccccc1)C=C6486.65 375-96-2 EICOSAFLUORNONAN C9F20FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F488.07 608-71-9 pentabromophenol C6HBr5O 488.59 Oc1c(Br)c(Br)c(Br)c(Br)c1Br 52109-40-7 8-sebenzylcyclicamp C17H18N5O6PSeOC(C2OP5(O)=O)C(OC2CO5)n4c(ncnc3N)c3nc4[Se]Cc1ccccc1498.29 2051-24-3 2,2`,3,3`,4,4`,5,5`,6,6`-DECACHLORBIPHENYL C12Cl10 Clc2c(Cl)c(Cl)c(c(Cl)c2Cl)c(c(Cl)c1Cl)c(Cl)c(Cl)c1Cl498.66 423-55-2 1-BROMO-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-HEPTADECAFLUOROCTANC8BrF17FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)Br498.96 58-36-6 10,10'-oxydiphenoxarsine C24H16As2O3O([As]6c2ccccc2Oc3ccccc63)[As]5c1ccccc1Oc4ccccc54502.23 1528-48-9 1,2,4-BENZENETRICARBOXYLICACID,TRIHEPTYLESTER C30H48O6CCCCCCCOC(=O)c1cc(C(OCCCCCCC)=O)ccc1C(OCCCCCCC)=O504.70 630-06-8 HEXATRIACONTAN C36H74CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC506.98 130-20-1 7,16-dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone C28H12Cl2N2O4Clc7c3[nH]c(c(C(=O)c1ccccc1C4=O)c4cc6Cl)c6[nH]c3c(C(=O)c2ccccc2C5=O)c5c7511.31 596-30-5 BIS-(TRIPHENYLMETHYL)-PEROXID C38H30O2O(OC(c3ccccc3)(c2ccccc2)c1ccccc1)C(c6ccccc6)(c5ccccc5)c4ccccc4518.65 85668-76-4 5,6-DIBUTYL-5,6-BIS(4-TERT.-BUTYLPHENYL)-DECAN CCCCC(CCCC)(C(CCCC)(CCCC)c(cc1)ccc1C(C)(C)C)c(cc2)ccc2C(C)(C)CC38H62 518.90 517-51-1 5,6,11,12-TETRAPHENYLNAPHTHACEN C42H28c(cc4)ccc4c(c6ccccc6c8c3ccccc3)c7c8c(c2ccccc2)c5ccccc5c7c1ccccc1532.68 541-01-5 HEXADECAMETHYLHEPTASILOXAN C16H48O6Si7C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C533.15 17455-25-3 1,4,7,10,13,16,19,22,25,27-DECAOXA-2,3,17,18-DIB C28H40O10O1c3c(OCCOCCOCCOCCOc2ccccc2OCCOCCOCCOCC1)cccc3536.61 87970-03-4 9h-purin-6-amine,9-[2-o-acetyl-3,5-bis-o-[(1,1-dimethylethyl)dimethylsilyl]-.beta.-d-arabinofuranosyl]-C24H43N5O5Si2CC(C)(C)[Si](C)(C)OCC2OC(C(C2O[Si](C)(C)C(C)(C)C)OC(C)=O)n1cnc3c1ncnc3N537.80 307-45-9 DOCOSAFLUORDECAN FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)FC10F22 538.07 77-63-4 2,4,6,8-TETRAMETHYL-2,4,6,8-TETRAPHENYLCYCLOTETRASILOXANC28H32O4Si4C[Si](O[Si]5(C)c2ccccc2)(O[Si](C)(O[Si](C)(O5)c4ccccc4)c1ccccc1)c3ccccc3544.90 3319-31-1 TRIS-(2-ETHYLHEXYL)-TRIMELLITAT CCCCC(CC)COC(=O)c(ccc1C(OCC(CC)CCCC)=O)cc1C(OCC(CC)CCCC)=OC33H54O6 546.78 87-82-1 HEXABROMBENZOL C6Br6 551.49 Brc1c(Br)c(Br)c(Br)c(Br)c1Br 87970-04-5 9-(2-o-propionyl-beta-d-arabinofuranosyl)adenine CC(C)(C)[Si](C)(C)OCC2OC(C(C2O[Si](C)(C)C(C)(C)C)OC(CC)=O)n1cnc3c1ncnc3NC25H45N5O5Si2 551.83 14548-59-5 tris(2,2,2-trinitroethyl)orthoformate O=N(=O)C(COC(OCC(N(=O)=O)(N(=O)=O)N(=O)=O)OCC(N(=O)=O)(N(=O)=O)N(=O)=O)(N(=O)=O)N(=O)=OC7H7N9O21 553.18 61868-18-6 1-TETRACONTEN C40H80CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC=C561.07 87970-05-6 9-(2-o-butyryl-beta-d-arabinofuranosyl)adenine CCCC(OC(C2O[Si](C)(C)C(C)(C)C)C(OC2CO[Si](C)(C)C(C)(C)C)n1cnc3c1ncnc3N)=OC26H47N5O5Si2 565.86 2475-31-2 5,5',7,7'-tetrabromoindigo C16H6Br4N2O2Brc3cc2C(=O)C(Nc2c(Br)c3)=C(Nc1c(Br)c4)C(c1cc4Br)=O577.85 87984-85-8 9h-purin-6-amine,9-[3,5-bis-o-[(1,1-dimethylethyl)dimethylsilyl]-2-o-(1-oxopentyl)-.beta.-d-arabinofuranosyl]-CCCCC(OC(C2O[Si](C)(C)C(C)(C)C)C(OC2CO[Si](C)(C)C(C)(C)C)n1cnc3c1ncnc3N)=OC27H49N5O5Si2 579.88 107538-74-9 8-sebenzylcyclicamp-o-benzyl C24H24N5O6PSeOC(C3OP6(OCc2ccccc2)=O)C(OC3CO6)n5c(ncnc4N)c4nc5[Se]Cc1ccccc1588.42 556-68-3 HEXADECAMETHYLCYCLOOCTASILOXAN C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1C16H48O8Si8 593.23 556-69-4 OCTADECAMETHYLOCTASILOXAN C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)CC18H54O7Si8 607.30 917-23-7 5,10,15,20-TETRAPHENYL-21H,23H-PORPHIN c(cc5)ccc5c(c3nc(C=C3)c(c6ccccc6)c4[nH]c(cc4)c9c7ccccc7)c1[nH]c(cc1)c(c8ccccc8)c2nc9C=C2C44H30N4 614.74 40882-83-5 tetra(3-pyridyl)porphyrin c(nc6)ccc6c(c4nc(C=C4)c(c7cccnc7)c1[nH]c(cc1)c(c5cccnc5)c2nc9C=C2)c(cc3)[nH]c3c9c8cccnc8C40H26N8 618.69 2465-32-9 (9Z)-OCTADECENSAEURE-2-HYDROXY-1,3-PROPANDIYLESTERCCCCCCCCC=CCCCCCCCC(OCC(O)COC(CCCCCCCC=CCCCCCCCC)=O)=OC39H72O5 620.99 307-59-5 HEXACOSAFLUORDODECAN FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)FC12F26 638.09 66841-25-6 [(s)-cyano-[3-(phenoxy)phenyl]methyl] (1r,3s)-2,2-dimethyl-3-(1,2,2,2-tetrabromoethyl)cyclopropane-1-carboxylateC22H19Br4NO3CC1(C)C(C1C(Br)C(Br)(Br)Br)C(OC(C#N)c3cc(Oc2ccccc2)ccc3)=O665.01 556-71-8 OCTADECAMETHYLCYCLONONASILOXAN C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1C18H54O9Si9 667.39 14527-51-6 21h,23h-porphin,5,10,15,20-tetrakis(4-methylphenylCc6ccc(cc6)c(c4nc9C=C4)c(cc2)[nH]c2c(c(cc5)ccc5C)c1nc(C=C1)c(c(cc8)ccc8C)c3[nH]c(cc3)c9c(cc7)ccc7CC48H38N4 670.85 2652-13-3 ICOSAMETHYLNONASILOXAN C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)CC20H60O8Si9 681.46 49753-54-0 2,4,6-TRIPICRYL-1,3,5-TRIAZIN O=N(=O)c(cc2N(=O)=O)cc(c2c(n4)nc(nc4c3c(cc(cc3N(=O)=O)N(=O)=O)N(=O)=O)c1c(cc(cc1N(=O)=O)N(=O)=O)N(=O)=O)N(=O)=OC21H6N12O18 714.34 14548-58-4 tetrabis(2,2,2-trinitroethyl(orthocarbonateO=N(=O)C(COC(OCC(N(=O)=O)(N(=O)=O)N(=O)=O)(OCC(N(=O)=O)(N(=O)=O)N(=O)=O)OCC(N(=O)=O)(N(=O)=O)N(=O)=O)(N(=O)=O)N(=O)=OC9H8N12O28 732.23 22112-78-3 5,10,15,20-TETRAKIS(4-METHOXYPHENYL)-21H,23H-PORPHINCOc5ccc(cc5)c(c1nc(C=C1)c(c(cc6)ccc6OC)c3[nH]c(cc3)c9c(cc7)ccc7OC)c2[nH]c(cc2)c(c(cc8)ccc8OC)c4nc9C=C4C48H38N4O4 734.84 107-53-9 TETRACOSAMETHYLUNDECASILOXAN C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)CC24H72O10Si11 829.77

Page 116 of 117 Appendix 2 List of potential alternative solvents screened by BASF

CAS Name Sufo MW Smiles 355-49-7 TETRATRIACONTAFLUORHEXADECAN FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)FC16F34 838.12 126-13-6 ALPHA-D-GLUCOPYRANOSIDE,6-0-ACETYL-1,3-4-TRIS-0-(2-METHYL-1-OXOPROPYL)-BETA-D-FCC(C)C(OCC1(OC(OC2COC(C)=O)C(C(C2OC(C(C)C)=O)OC(C(C)C)=O)OC(C(C)C)=O)OC(COC(C)=O)C(C1OC(C(C)C)=O)OC(C(C)C)=O)=OC40H62O19 846.91 122-32-7 (9Z)-9-OCTADECENSAEURE-1,2,3-PROPANTRIYLESTERCCCCCCCCC=CCCCCCCCC(OCC(COC(CCCCCCCC=CCCCCCCCC)=O)OC(CCCCCCCC=CCCCCCCCC)=O)=OC57H104O6 885.44 2471-08-1 HEXACOSAMETHYLDODECASILOXANEC[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)CC26H78O11Si12 903.92 29162-73-0 tetra(p-bromophenyl)porphyrin Brc6ccc(cc6)c(c3nc9C=C3)c(cc2)[nH]c2c(c(cc5)ccc5Br)c1nc(C=C1)c(c(cc7)ccc7Br)c(cc4)[nH]c4c9c(cc8)ccc8BrC44H26Br4N4 930.32 28888-81-5 HEXADECACHLORPHTHALOCYANID Clc5c(Cl)c1c(c(Cl)c5Cl)c(nc1nc3[nH]c(nc4n9)c(c(Cl)c6Cl)c3c(Cl)c6Cl)nc2[nH]c(nc9c(c(Cl)c7Cl)c4c(Cl)c7Cl)c(c(Cl)c8Cl)c2c(Cl)c8ClC32H2Cl16N8 1065.67 28746-04-5 HEXADECABROMPHTHALOCYANID Brc5c(Br)c1c(c(Br)c5Br)c(nc1nc3[nH]c(nc4n9)c(c(Br)c6Br)c3c(Br)c6Br)nc2[nH]c(nc9c(c(Br)c7Br)c4c(Br)c7Br)c(c(Br)c8Br)c2c(Br)c8BrC32H2Br16N8 1776.88

Page 117 of 117 ANALYSIS OF ALTERNATIVES and SOCIO-ECONOMIC ANALYSIS

Appendix 3: Report on approach to screening of potential alternative solvents

[Confidentiality claim type #5/#6. 15 pages redacted.]

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