The Window on the Soul
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Biophotonic Probes for Bio-Detection and Imaging Ting Pan1,Dengyunlu1, Hongbao Xin 1 and Baojun Li 1
Pan et al. Light: Science & Applications (2021) 10:124 Official journal of the CIOMP 2047-7538 https://doi.org/10.1038/s41377-021-00561-2 www.nature.com/lsa REVIEW ARTICLE Open Access Biophotonic probes for bio-detection and imaging Ting Pan1,DengyunLu1, Hongbao Xin 1 and Baojun Li 1 Abstract The rapid development of biophotonics and biomedical sciences makes a high demand on photonic structures to be interfaced with biological systems that are capable of manipulating light at small scales for sensitive detection of biological signals and precise imaging of cellular structures. However, conventional photonic structures based on artificial materials (either inorganic or toxic organic) inevitably show incompatibility and invasiveness when interfacing with biological systems. The design of biophotonic probes from the abundant natural materials, particularly biological entities such as virus, cells and tissues, with the capability of multifunctional light manipulation at target sites greatly increases the biocompatibility and minimizes the invasiveness to biological microenvironment. In this review, advances in biophotonic probes for bio-detection and imaging are reviewed. We emphatically and systematically describe biological entities-based photonic probes that offer appropriate optical properties, biocompatibility, and biodegradability with different optical functions from light generation, to light transportation and light modulation. Three representative biophotonic probes, i.e., biological lasers, cell-based biophotonic waveguides and -
RS BA Meeting.2016
Biological Action in Read-Write Genome Evolution Royal Society-British Academy, “New trends in evolutionary biology,” November 7-9, 2016 James A. Shapiro University of Chicago [email protected] www.shapiro.bsd.uchicago.edu Living Organisms Regularly Use Generic Activities to Facilitate Evolution • Taxonomic divergences and adaptive innovations often result from abrupt, widespread cell-mediated and biochemical modifications of RW genomes rather than gradual accumulation of independent localized copying errors in ROM genomes. • Abrupt genome rewriting processes include symbiogenesis, horizontal DNA transfers, interspecific hybridizations, and mobilization of repetitive DNA elements to rewire genome networks and regulatory ncRNAs. • Ecological conditions and population interactions stimulate evolutionary variation. • Conclusion: living organisms have core biological/molecular tools to rewrite their genomes actively when challenged. Well-documented classes of active RW genome inscription lead repeatedly to adaptive and taxonomic novelties: • Hereditary variation, adaptations and taxonomic originations by cell mergers (symbiogenesis); • Acquisition of evolved functional adaptations from other taxaa by horizontal DNA transfers; • Taxonomic originations and adaptive radiations by interspecific hybridizations and whole genome doublings; • Protein evolution by exon shuffling; • Amplification of so-called “noncoding” repetitive components in the genome as evolution produces increasingly complex organisms; • Mobile DNA elements rewiring taxonomically-specific -
The Role of Motion Streaks in the Perception of the Kinetic Zollner Illusion
Journal of Vision (2012) 12(6):19, 1–14 http://www.journalofvision.org/content/12/6/19 1 The role of motion streaks in the perception of the kinetic Zollner illusion The School of Optometry and Vision Science, The University of New South Wales, Sieu K. Khuu Sydney, New South Wales $ In classic geometric illusions such as the Zollner illusion, vertical lines superimposed on oriented background lines appear tilted in the direction opposite to the background. In kinetic forms of this illusion, an object moving over oriented background lines appears to follow a titled path, again in the direction opposite to the background. Existing literature does not proffer a complete explanation of the effect. Here, it is suggested that motion streaks underpin the illusion; that the effect is a consequence of interactions between detectors tuned to the orientation of background lines and those sensing the motion streaks that arise from fast object motion. This account was examined in the present study by measuring motion-tilt induction under different conditions in which the strength or salience of motion streaks was attenuated: by varying object speed (Experiment 1), contrast (Experiment 2), and trajectory/length by changing the element life-time within the stimulus (Experiment 3). It was predicted that, as motion streaks become less available, background lines would less affect the perceived direction of motion. Consistent with this prediction, the results indicated that, with a reduction in object speed below that required to generate motion streaks (, 1.128/s), Weber contrast (, 0.125) and motion streak length (two frames) reduced or extinguished the motion-tilt-induction effect. -
Geometrical Optical Illusion Via Sub-Riemannian Geodesics in the Roto-Translation Group
Geometrical Optical Illusion via Sub-Riemannian Geodesics in the Roto-Translation Group B. Franceschiello1, A. Mashtakov2, G. Citti3, and A. Sarti4 1 Fondation Asile des Aveugles and Laboratory for Investigative Neurophisiology, Department of Radiology, CHUV - UNIL, Lausanne 2 Program Systems Institute of RAS, Russia, CPRC, 3 Department of Mathematics, University of Bologna, Italy 4 CAMS, Center of Mathematics, CNRS - EHESS,Paris, France [email protected], [email protected], [email protected], [email protected] Abstract. We present a neuro-mathematical model for geometrical op- tical illusions (GOIs), a class of illusory phenomena that consists in a mismatch of geometrical properties of the visual stimulus and its associ- ated percept. They take place in the visual areas V1/V2 whose functional architecture have been modelled in previous works by Citti and Sarti as a Lie group equipped with a sub-Riemannian (SR) metric. Here we ex- tend their model proposing that the metric responsible for the cortical connectivity is modulated by the modelled neuro-physiological response of simple cells to the visual stimulus, hence providing a more biologically plausible model that takes into account a presence of visual stimulus. Il- lusory contours in our model are described as geodesics in the new metric. The model is confirmed by numerical simulations, where we compute the geodesics via SR-Fast Marching. 1 Introduction Geometrical-optical illusions (GOIs) have been discovered in the XIX century by German psychologists (Oppel 1854 [50], Hering, 1878,[33]) and have been defined as situations in which there is an awareness of a mismatch of geometrical prop- erties between an item in the object space and its associated percept [68]. -
Computational Role of Disinhibition in Brain Function
COMPUTATIONAL ROLE OF DISINHIBITION IN BRAIN FUNCTION A Dissertation by YINGWEI YU Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY August 2006 Major Subject: Computer Science COMPUTATIONAL ROLE OF DISINHIBITION IN BRAIN FUNCTION A Dissertation by YINGWEI YU Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Approved by: Chair of Committee, Yoonsuck Choe Committee Members, Ricardo Gutierrez-Osuna Thomas Ioerger Takashi Yamauchi Head of Department, Valerie E. Taylor August 2006 Major Subject: Computer Science iii ABSTRACT Computational Role of Disinhibition in Brain Function. (August 2006) Yingwei Yu, B.E., Beihang University, China Chair of Advisory Committee: Dr. Yoonsuck Choe Neurons are connected to form functional networks in the brain. When neurons are combined in sequence, nontrivial effects arise. One example is disinhibition; that is, inhibition to another inhibitory factor. Disinhibition may be serving an important purpose because a large number of local circuits in the brain contain disinhibitory connections. However, their exact functional role is not well understood. The objective of this dissertation is to analyze the computational role of dis- inhibition in brain function, especially in visual perception and attentional control. My approach is to propose computational models of disinhibition and then map the model to the local circuits in the brain to explain psychological phenomena. Several computational models are proposed in this dissertation to account for disinhibition. (1) A static inverse difference of Gaussian filter (IDoG) is derived to account explic- itly for the spatial effects of disinhibition. -
Living Organisms Author Their Read-Write Genomes in Evolution
biology Review Living Organisms Author Their Read-Write Genomes in Evolution James A. Shapiro ID Department of Biochemistry and Molecular Biology, University of Chicago GCIS W123B, 979 E. 57th Street, Chicago, IL 60637, USA; [email protected]; Tel.: +1-773-702-1625 Academic Editor: Andrés Moya Received: 23 August 2017; Accepted: 28 November 2017; Published: 6 December 2017 Abstract: Evolutionary variations generating phenotypic adaptations and novel taxa resulted from complex cellular activities altering genome content and expression: (i) Symbiogenetic cell mergers producing the mitochondrion-bearing ancestor of eukaryotes and chloroplast-bearing ancestors of photosynthetic eukaryotes; (ii) interspecific hybridizations and genome doublings generating new species and adaptive radiations of higher plants and animals; and, (iii) interspecific horizontal DNA transfer encoding virtually all of the cellular functions between organisms and their viruses in all domains of life. Consequently, assuming that evolutionary processes occur in isolated genomes of individual species has become an unrealistic abstraction. Adaptive variations also involved natural genetic engineering of mobile DNA elements to rewire regulatory networks. In the most highly evolved organisms, biological complexity scales with “non-coding” DNA content more closely than with protein-coding capacity. Coincidentally, we have learned how so-called “non-coding” RNAs that are rich in repetitive mobile DNA sequences are key regulators of complex phenotypes. Both biotic and abiotic ecological challenges serve as triggers for episodes of elevated genome change. The intersections of cell activities, biosphere interactions, horizontal DNA transfers, and non-random Read-Write genome modifications by natural genetic engineering provide a rich molecular and biological foundation for understanding how ecological disruptions can stimulate productive, often abrupt, evolutionary transformations. -
BMC Evolutionary Biology Biomed Central
BMC Evolutionary Biology BioMed Central Research article Open Access Molecular phylogeny of ocelloid-bearing dinoflagellates (Warnowiaceae) as inferred from SSU and LSU rDNA sequences Mona Hoppenrath*1,4, Tsvetan R Bachvaroff2, Sara M Handy3, Charles F Delwiche3 and Brian S Leander1 Address: 1Departments of Botany and Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, BC, V6T 1Z4, Canada, 2Smithsonian Environmental Research Center, Edgewater, MD 21037-0028, USA, 3Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742-4407, USA and 4Current address : Forschungsinstitut Senckenberg, Deutsches Zentrum für Marine Biodiversitätsforschung (DZMB), Südstrand 44, D-26382 Wilhelmshaven, Germany Email: Mona Hoppenrath* - [email protected]; Tsvetan R Bachvaroff - [email protected]; Sara M Handy - [email protected]; Charles F Delwiche - [email protected]; Brian S Leander - [email protected] * Corresponding author Published: 25 May 2009 Received: 24 February 2009 Accepted: 25 May 2009 BMC Evolutionary Biology 2009, 9:116 doi:10.1186/1471-2148-9-116 This article is available from: http://www.biomedcentral.com/1471-2148/9/116 © 2009 Hoppenrath et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Dinoflagellates represent a major lineage of unicellular eukaryotes with unparalleled diversity and complexity in morphological features. The monophyly of dinoflagellates has been convincingly demonstrated, but the interrelationships among dinoflagellate lineages still remain largely unresolved. Warnowiid dinoflagellates are among the most remarkable eukaryotes known because of their possession of highly elaborate ultrastructural systems: pistons, nematocysts, and ocelloids. -
Applying Emmert's Law to the Poggendorff Illusion
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Frontiers - Publisher Connector ORIGINAL RESEARCH published: 16 October 2015 doi: 10.3389/fnhum.2015.00531 Applying Emmert’s Law to the Poggendorff illusion Umur Talasli and Asli Bahar Inan* Department of Psychology, Atilim University, Ankara, Turkey The Poggendorff illusion was approached with a novel perspective, that of applying Emmert’s Law to the situation. The extensities between the verticals and the transversals happen to be absolutely equal in retinal image size, whereas the registered distance for the verticals must be smaller than that of the transversals due to the fact that the former is assumed to occlude the latter. This combination of facts calls for the operation of Emmert’s Law, which results in the shrinkage of the occluding space between the verticals. Since the retinal image shows the transversals to be in contact with the verticals, the shrinkage must drag the transversals inwards in the cortical representation in order to eliminate the gaps. Such dragging of the transversals produces the illusory misalignment, which is a dictation of geometry. Some of the consequences of this new explanation were tested in four different experiments. In Experiment 1, a new illusion, the tilting of an occluded continuation of an oblique line, was predicted and achieved. In Experiments 2 and 3, perceived nearness of the occluding entity was Edited by: manipulated via texture density variations and the predicted misalignment variations Baingio Pinna, were confirmed by using a between-subjects and within-subjects designs, respectively. University of Sassari, Italy In Experiment 4, tilting of the occluded segment of the transversal was found to vary in Reviewed by: Branka Spehar, the predicted direction as a result of being accompanied by the same texture cues used University of New South Wales, in Experiments 2 and 3. -
Neuropsychologia the Poggendorff Illusion Affects Manual Pointing As
Neuropsychologia 47 (2009) 3217–3224 Contents lists available at ScienceDirect Neuropsychologia journal homepage: www.elsevier.com/locate/neuropsychologia The Poggendorff illusion affects manual pointing as well as perceptual judgements Dean R. Melmoth, Marc S. Tibber, Simon Grant, Michael J. Morgan ∗ Henry Wellcome Laboratories, Department of Optometry and Visual Science, City University, Northampton Square, London EC1 V 0HB, United Kingdom article info abstract Article history: Pointing movements made to a target defined by the imaginary intersection of a pointer with a distant Received 28 July 2009 landing line were examined in healthy human observers in order to determine whether such motor Accepted 30 July 2009 responses are susceptible to the Poggendorff effect. In this well-known geometric illusion observers Available online 7 August 2009 make systematic extrapolation errors when the pointer abuts a second line (the inducer). The kinemat- ics of extrapolation movements, in which no explicit target was present, where similar to those made Keywords: in response to a rapid-onset (explicit) dot target. The results unambiguously demonstrate that motor Action (pointing) responses are susceptible to the illusion. In fact, raw motor biases were greater than for per- Perception Dorsal ceptual responses: in the absence of an inducer (and hence also the acute angle of the Poggendorff Ventral stimulus) perceptual responses were near-veridical, whilst motor responses retained a bias. Therefore, Pointing the full Poggendorff stimulus contained two biases: one mediated by the acute angle formed between Illusions the oblique pointer and the inducing line (the classic Poggendorff effect), which affected both motor and perceptual responses equally, and another bias, which was independent of the inducer and primarily affected motor responses. -
The Influence of Visual Perception on the Academic Performance of the Mentally Retarded
Western Michigan University ScholarWorks at WMU Master's Theses Graduate College 4-1971 The Influence of Visual erP ception on the Academic Performance of the Mentally Retarded Shirley A. Knapp Follow this and additional works at: https://scholarworks.wmich.edu/masters_theses Part of the Special Education and Teaching Commons Recommended Citation Knapp, Shirley A., "The Influence of Visual Perception on the Academic Performance of the Mentally Retarded" (1971). Master's Theses. 2874. https://scholarworks.wmich.edu/masters_theses/2874 This Masters Thesis-Open Access is brought to you for free and open access by the Graduate College at ScholarWorks at WMU. It has been accepted for inclusion in Master's Theses by an authorized administrator of ScholarWorks at WMU. For more information, please contact [email protected]. THE INFLUENCE OF VISUAL PERCEPTION ON THE ACADEMIC PERFORMANCE OF THE MENTALLY RETARDED by / " * ■ Shirley A. Knapp A Project Report Submitted to the Faculty of the Graduate College in partial fulfillment of the Specialist in Education Degree Western Michigan University Kalamazoo, Michigan April 1971 Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. THE INFLUENCE OF VISUAL PERCEPTION ON THE ACADEMIC PERFORMANCE OF THE MENTALLY RETARDED Shirley A. Knapp, Ed.S. Western Michigan University, 1971 Visual perception refers to the process of receiving and analyzing sensory information through the medium of the eye. The report extensively surveys literature concerning the developmental processes and characteristics of visual perception. The research tended to show a relationship between visual perceptual maturity and academic achievement. The prominent remedial programs were discussed in conjunction with supporting or disputing research concerning the alleged benefits. -
Sub-Riemannian Problems on 3D Lie Groups with Applications to Retinal
Sub-Riemannian Geometry in Image Processing and Modelling of Human Visual System Alexey Mashtakov Program Systems Institute of RAS Based on joint works with R. Duits, Yu. Sachkov, G. Citti, A. Sarti, A. Popov E. Bekkers, G. Sanguinetti, A. Ardentov, B. Franceschiello I. Beschastnyi, A. Ghosh and T.C.J. Dela Haije Scientific Heritage of Sergei A. Chaplygin Nonholonomic Mechanics, Vortex Structures and Hydrodynamics Cheboksary, Russia, 06.06.2019 SR geodesics on Lie Groups in Image Processing Crossing structures are Reconstruction of corrupted contours disentangled based on model of human vision Applications in medical image analysis SE(2) SO(3) SE(3) 2 Left-invariant sub-Riemannian structures 3 Optimal Control Problem: ODE-based Approach Optimality of Extremal Trajectories 5 Sub-Riemannian Wave Front 6 Sub-Riemannian Wave Front 7 Sub-Riemannian Wave Front 8 Self intersection of Sub-Riemannian Wave Front General case: astroidal shape of conjugate locus Special case with rotational symmetry A.Agrachev, Exponential mappings for contact sub-Riemannian structures. JDCS, 1996. 9 H. Chakir, J.P. Gauthier and I. Kupka, Small Subriemannian Balls on R3. JDCS, 1996. Sub-Riemannian Sphere 10 Sub-Riemannian Length Minimizers 11 Brain Inspired Methods in Computer Vision 12 12 Perception of Visual Information by Human Brain LGN (lateral geniculate nucleus) LGN V1 V1 13 Primary visual cortex A Model of the Primary Visual Cortex V1 Replicated from R. Duits, U. Boscain, F. Rossi, Y. Sachkov, 14 Association Fields via Cuspless Sub-Riemannian Geodesics in SE(2), JMIV, 2013. Cortical Based Model of Perceptual Completion 15 Detection of salient curves in images 16 16 Analysis of Images of the Retina Diabetic retinopathy --- one of the main causes of blindness. -
Book XVII License and the Law Editor: Ramon F
8 88 8 8nd 8 8888on.com 8888 Basic Photography in 180 Days Book XVII License and the Law Editor: Ramon F. aeroramon.com Contents 1 Day 1 1 1.1 Photography and the law ....................................... 1 1.1.1 United Kingdom ....................................... 2 1.1.2 United States ......................................... 6 1.1.3 Hong Kong .......................................... 8 1.1.4 Hungary ............................................ 8 1.1.5 Macau ............................................. 8 1.1.6 South Africa ......................................... 8 1.1.7 Sudan and South Sudan .................................... 9 1.1.8 India .............................................. 10 1.1.9 Iceland ............................................ 10 1.1.10 Spain ............................................. 10 1.1.11 Mexico ............................................ 10 1.1.12 See also ............................................ 10 1.1.13 Notes ............................................. 10 1.1.14 References .......................................... 10 1.1.15 External links ......................................... 12 2 Day 2 13 2.1 Observation .............................................. 13 2.1.1 Observation in science .................................... 14 2.1.2 Observational paradoxes ................................... 14 2.1.3 Biases ............................................. 15 2.1.4 Observations in philosophy .................................. 16 2.1.5 See also ...........................................