DOCSLIB.ORG

030821 a Comparison of Coronary Angioplasty With

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
030821 a Comparison of Coronary Angioplasty With The new england journal of medicine established in 1812 august 21, 2003 vol. 349 no. 8 A Comparison of Coronary Angioplasty with Fibrinolytic Therapy in Acute Myocardial Infarction Henning R. Andersen, M.D., Torsten T. Nielsen, M.D., Klaus Rasmussen, M.D., Leif Thuesen, M.D., Henning Kelbaek, M.D., Per Thayssen, M.D., Ulrik Abildgaard, M.D., Flemming Pedersen, M.D., Jan K. Madsen, M.D., Peer Grande, M.D., Anton B. Villadsen, M.D., Lars R. Krusell, M.D., Torben Haghfelt, M.D., Preben Lomholt, M.D., Steen E. Husted, M.D., Else Vigholt, M.D., Henrik K. Kjaergard, M.D., and Leif Spange Mortensen, M.Sc., for the DANAMI-2 Investigators* abstract background For the treatment of myocardial infarction with ST-segment elevation, primary angio- From the Departments of Cardiology at plasty is considered superior to fibrinolysis for patients who are admitted to hospitals Skejby Hospital, Aarhus University Hospi- tal, Aarhus (H.R.A., T.T.N., L.T., L.R.K.); Aal- with angioplasty facilities. Whether this benefit is maintained for patients who require borg University Hospital, Aalborg (K.R., transportation from a community hospital to a center where invasive treatment is avail- A.B.V.); Rigshospitalet University Hospital, able is uncertain. Copenhagen (H.K., J.K.M., P.G.); Odense University Hospital, Odense (P.T., T.H.); and the Gentofte Hospital, Hellerup (U.A.); methods the Departments of Medicine at Hilleroed We randomly assigned 1572 patients with acute myocardial infarction to treatment with Hospital, Hilleroed (F.P.); Randers Hospi- tal, Randers (P.L.); Aarhus County Hospi- angioplasty or accelerated treatment with intravenous alteplase; 1129 patients were en- tal and Aarhus University Hospital, Aarhus rolled at 24 referral hospitals and 443 patients at 5 invasive-treatment centers. The pri- (S.E.H.); and Horsens Hospital, Horsens mary study end point was a composite of death, clinical evidence of reinfarction, or dis- (E.V.); the Department of Cardiothoracic Surgery, Gentofte Hospital, Hellerup abling stroke at 30 days. (H.K.K.); and UNI-C, Danish Information Technology Centre for Education and Re- results search, Aarhus (L.S.M.) — all in Denmark. Address reprint requests to Dr. Andersen Among patients who underwent randomization at referral hospitals, the primary end at the Department of Cardiology, Skejby point was reached in 8.5 percent of the patients in the angioplasty group, as compared Hospital, Aarhus University Hospital, with 14.2 percent of those in the fibrinolysis group (P=0.002). The results were similar DK-8200 Aarhus N, Denmark, or at [email protected]. among patients who were enrolled at invasive-treatment centers: 6.7 percent of the pa- tients in the angioplasty group reached the primary end point, as compared with 12.3 *Participants in the Danish Multicenter percent in the fibrinolysis group (P=0.05). Among all patients, the better outcome after Randomized Study on Fibrinolytic Thera- py versus Acute Coronary Angioplasty in angioplasty was driven primarily by a reduction in the rate of reinfarction (1.6 percent in Acute Myocardial Infarction (DANAMI-2) the angioplasty group vs. 6.3 percent in the fibrinolysis group, P<0.001); no significant are listed in the Appendix. differences were observed in the rate of death (6.6 percent vs. 7.8 percent, P=0.35) or the N Engl J Med 2003;349:733-42. rate of stroke (1.1 percent vs. 2.0 percent, P=0.15). Ninety-six percent of patients were Copyright © 2003 Massachusetts Medical Society. transferred from referral hospitals to an invasive-treatment center within two hours. conclusions A strategy for reperfusion involving the transfer of patients to an invasive-treatment center for primary angioplasty is superior to on-site fibrinolysis, provided that the trans- fer takes two hours or less. n engl j med 349;8 www.nejm.org august 21, 2003 733 The new england journal of medicine ercutaneous coronary interven- ceived 300 mg of aspirin intravenously, the same ption has been shown to be superior to fibri- dose of a beta-blocker as patients in the fibrinolysis nolysis in the treatment of acute myocardial group, and 10,000 U of unfractionated heparin. Ad- infarction with ST-segment elevation in patients ad- ditional heparin was given to achieve an activated mitted to highly experienced angioplasty centers.1-4 clotting time of 350 to 450 seconds during the inva- In Western countries, primary angioplasty is offered sive procedure. Platelet glycoprotein IIb/IIIa–recep- only to the limited number of patients admitted tor blockers were administered at the discretion of directly to hospitals with interventional services. the physician. The infarct-related artery was treated Transportation from the local hospital to an angio- if it was totally occluded, if there was a culprit lesion plasty center has been considered to represent a ma- with stenosis of more than 30 percent of the luminal jor limitation on the widespread use of primary an- diameter, or if it had a flow grade of less than 3 ac- gioplasty. We conducted a community-wide trial to cording to the Thrombolysis in Myocardial Infarc- compare the transfer of patients for primary angio- tion (TIMI) classification.5 Stenting of the culprit le- plasty with the use of on-site fibrinolysis. sion was attempted in all patients, unless the vessel had a diameter of less than 2.0 mm. Angioplasty methods of non–infarct-related arteries was not performed. Patients were not considered for immediate coro- study design nary-artery bypass grafting unless they had severe We randomly assigned patients who had myocardial hemodynamic instability. Ticlopidine (500 mg) or infarction with ST-segment elevation to fibrinolysis clopidogrel (75 mg) was given daily for one month or primary angioplasty. From December 1997 to after stenting. The angiograms obtained before and October 2001, we enrolled patients from 24 refer- after angioplasty were evaluated by an independent ral hospitals without angioplasty facilities and 5 in- core laboratory (Cardialysis, Rotterdam, the Nether- vasive-treatment hospitals with such facilities and lands). on-site surgical backup. The participating hospitals When failed reperfusion was suspected (i.e., served 62 percent of the Danish population. Patients when there was no resolution of ST-segment eleva- admitted to a referral hospital underwent random- tion) or when there was reinfarction or recurrent is- ization while they lay on the ambulance stretcher chemia with ST-segment elevation after fibrinolysis, with the crew waiting. Transfer to the nearest angio- the protocol recommended repeated fibrinolysis plasty center had to be completed within three before consideration of rescue angioplasty. An early hours. A physician accompanied the patient. All am- or late reinfarction or recurrent ischemia in patients bulances had resuscitation equipment. The patients with an index infarction that had been treated by an- were transported directly to the catheterization lab- gioplasty was treated by repeated angioplasty. oratory. The primary end point was a composite of death from any cause, clinical reinfarction, or disabling treatment stroke at 30 days of follow-up. Procedure-related Patients randomly assigned to fibrinolysis received reinfarction was not included in the primary end 300 mg of aspirin orally, a beta-blocker intrave- point. A reinfarction was diagnosed if there was an nously (up to the equivalent of 20 mg of metopro- increase in the total creatine kinase and MB isoen- lol), accelerated treatment with tissue plasminogen zyme activity and either a history of ischemic chest activator (alteplase, given as a 15-mg bolus and an discomfort or electrocardiographic changes. Clini- infusion of 0.75 mg per kilogram of body weight cal reinfarction was diagnosed if the creatine kinase administered over a period of 30 minutes, followed MB level increased to above a reference limit in a pa- by an infusion of 0.5 mg per kilogram for a period of tient in whom the level had normalized after the in- 60 minutes), and an intravenous bolus of unfrac- dex infarction or if there was an increase of at least tionated heparin (5000 U), followed by a 48-hour in- 50 percent from the last non-normalized measure- fusion of unfractionated heparin. The starting dose ment. A procedure-related reinfarction was diag- of unfractionated heparin was 1000 U per hour; the nosed after coronary-artery bypass surgery if the cre- dose was adjusted to maintain an activated partial- atine kinase MB level increased to five times the thromboplastin time of 70 to 90 seconds. upper limit of normal or five times the preceding lev- Patients randomly assigned to angioplasty re- el; a procedure-related reinfarction was diagnosed 734 n engl j med 349;8 www.nejm.org august 21, 2003 coronary angioplasty versus fibrinolytic therapy in acute myocardial infarction after angioplasty if the level increased to twice the went randomization at referral hospitals and the upper limit of normal or twice the last non-normal- other involving patients who underwent randomiza- ized measurement. tion at invasive-treatment centers. The results were Disabling stroke was defined as a fatal stroke or analyzed both separately for each substudy and for a stroke causing a clinically significant mental or the two substudies combined. Each substudy was physical handicap at 30 days of follow-up. Clinically designed with two groups, interim analyses, and significant handicaps were defined as ranging from stopping rules, with an overall two-sided alpha of slight disability (i.e., the inability to engage in all 5 percent and a power (1 ¡ beta) of 80 percent. previous activities in a patient who was still able to The calculation of the sample size was based on take care of himself or herself without assistance) the assumption that the combined primary end to very severe disability (i.e., a bedridden state in- point would be reached by 30 days in 16 percent of volving a requirement for constant nursing care and the patients randomly assigned to fibrinolysis, in attention).
Load more

Recommended publications
  • Mosaics and Moles Lone Sunde, Isa Niemann, Estrid Stæhr Hansen, Johnny Hindkjaer, Birte Degn, Uffe Birk Jensen, Lars Bolund
    Mosaics and Moles Lone Sunde, Isa Niemann, Estrid Stæhr Hansen, Johnny Hindkjaer, Birte Degn, Uffe Birk Jensen, Lars Bolund To cite this version: Lone Sunde, Isa Niemann, Estrid Stæhr Hansen, Johnny Hindkjaer, Birte Degn, et al.. Mosaics and Moles. European Journal of Human Genetics, Nature Publishing Group, 2011, 10.1038/ejhg.2011.93. hal-00649448 HAL Id: hal-00649448 https://hal.archives-ouvertes.fr/hal-00649448 Submitted on 8 Dec 2011 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. 1 TITLE: Mosaics and moles AUTHORS: Lone Sunde1,2 Department of Clinical Genetics, Aarhus University Hospital, Aalborg Sygehus, DK- 9000 Aalborg, Denmark3 Department of Human Genetics, Aarhus University, DK-8000 Aarhus, Denmark Phone: 0045 9932 8952 Mobil phone: 0045 4014 4364 and 0045 4020 3199 FAX: 0045 9932 8940 E-mail: [email protected] and [email protected] Isa Niemann2 Department of Gynaecology and Obstetrics, Aarhus University Hospital, Skejby Sygehus, DK-8200 Aarhus, Denmark Estrid Staehr Hansen University Insitute of Pathology, Aarhus University Hospital, Aarhus
    [Show full text]
  • Programme for the Phd Day 2010 (Full
    UNIVERSITY OF AARHUS GRADUATE SCHOOL OF HEALTH SCIENCES PhD Day 15 January 2010 2 Welcome It is our pleasure to welcome students, faculty, and guests to the PhD Day 2010. We warmly thank all those who have taken the time to participate and help make the PhD Day a leading event in the training of our graduate students. The world of science is by nature global and to go international is a key ambition of the PhD programme in Denmark. Aarhus Graduate School of Health Sciences acknowledges that internationalisation is a very important aspect of science, not least for the individual PhD student. One way to support internationalisation is by networking. The theme of the PhD Day 2010 is thus INTERNATIONAL NETWORKING. Nine PhD students coming from USA, England, Sweden, Switzerland, and France will spend a day with PhD students from Aarhus. They were invited by the respective Graduate Programmes and we trust that this day of science related as well as social activities will lead to new contacts, further networking and new collaborations across borders. As is evident from the abstracts presented in this programme book the Aarhus Graduate School of Health Sciences provides a vibrant scientific environment ready to meet new challenges and offering many opportunities. The PhD students are central to research and research environments and the Organizing Committee is satisfied that this book shows the commitment and high quality research done at our Faculty. The Organizing Committee and the Faculty of Health Sciences are confident that the PhD Day 2010 will be a success and we cordially welcome all participants.
    [Show full text]
  • A Longitudinal Study of Serum Cobalamins and Its Binding Proteins in Lactating Women
    European Journal of Clinical Nutrition (2007) 61, 184–189 & 2007 Nature Publishing Group All rights reserved 0954-3007/07 $30.00 www.nature.com/ejcn ORIGINAL ARTICLE A longitudinal study of serum cobalamins and its binding proteins in lactating women AL Mørkbak1*, CH Ramlau-Hansen2, UK Møller3, TB Henriksen4, J Møller5 and E Nexø1 1Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark; 2Department of Occupational Medicine, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark; 3Department of Endorinology, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark; 4Perinatal Epidemiology Research Unit, Department of Obstetrics and Paediatrics, Aarhus University Hospital, Skejby Sygehus, Aarhus, Denmark and 5Department of Clinical Biochemistry, Aarhus University Hospital, Skejby Sygehus, Aarhus, Denmark Objective: To examine longitudinal changes in serum cobalamins, transcobalamin (TC) and haptocorrin (HC) during lactation and to investigate the influence of vitamin B12 supplementation on these parameters. Design: A 9-month follow-up study. Subjects and methods: Lactating mothers (N ¼ 89) including 23 supplemented with vitamin B12 (1–18 mg/daily), 41 partly supplemented and 25 not supplemented. Blood samples collected 3 weeks (baseline) and 4 and 9 months post-partum were analysed for cobalamins, TC and HC. Both the total concentration and the cobalamin-saturated form (holo) of TC and HC were analysed. Results: No significant differences were observed in serum cobalamins or its binding proteins related to supplementation with vitamin B12 or the duration of lactation. Serum cobalamins remained unchanged from 3 weeks to 9 months post-partum. Total TC (holoTC) (median7s.e. pmol/l) decreased between 3 weeks (710723 (85712)) and 9 months (602721 (76711)) (Po0.0001 (P ¼ 0.0002)), whereas total HC (holoHC) increased from (422711 (30079)) at 4 months to (455713 (317710)) to 9 months post-partum (Po0.0001 (Po0.0001)).
    [Show full text]
  • Increased Plasma Methylmalonic Acid Level Does Not Predict Clinical Manifestations of Vitamin B12 Deficiency
    ORIGINAL INVESTIGATION Increased Plasma Methylmalonic Acid Level Does Not Predict Clinical Manifestations of Vitamin B12 Deficiency Anne-Mette Hvas, MD; Jørgen Ellegaard, MD; Ebba Nexø, MD Background: The prevalence of vitamin B12 defi- pants, P-MMA levels increased substantially, whereas 44% ciency, defined as an elevated concentration of plasma showed a decrease. Level of P-MMA was significantly but methylmalonic acid (P-MMA), has been estimated to be not strongly associated with levels of plasma cobala- 15% to 44% in the elderly. However, we do not know mins (r=−0.22, P,.001) and plasma total homocyste- whether an increased P-MMA level actually indicates or ine (r=0.37, P,.001). After adjustment for age and sex, predicts a clinical condition in need of treatment. we found no associations between P-MMA concentra- tion and the total symptom score (P=.61), the total Neu- Participants and Methods: In a follow-up study, 432 rological Disability Score (P=.64), or other clinical mani- individuals not treated with vitamin B12 were examined festations related to vitamin B12 deficiency. 1.0 to 3.9 years after initial observation of an increased P-MMA concentration (.0.28 µmol/L). The examina- Conclusions: An increased level of P-MMA did not tion included laboratory tests, a structured interview to predict a further increase with time and clinical mani- disclose symptoms, a food frequency questionnaire, and festations related to vitamin B12 deficiency. We there- a clinical examination including a Neurological Disabil- fore challenge the use of an increased P-MMA concen- ity Score. tration as the only marker for diagnosis of vitamin B12 deficiency.
    [Show full text]
  • Estimating the Organ Donor Potential in Denmark: a Prospective Analysis of Deaths in Intensive Care Units in Northern Denmark
    Estimating the Organ Donor Potential in Denmark: A Prospective Analysis of Deaths in Intensive Care Units in Northern Denmark M. Madsen and L. Bøgh ABSTRACT To estimate the organ donor potential in Denmark we conducted a prospective registra- tion of deaths in all intensive care units (ICUs), counting 15 ICUs and two neurosurgical ICUs in the four northern Danish counties, which cover a population of 1.64 million inhabitants or 30% of the Danish population. From September 1, 2000 till August 31, 2002, all deaths in the ICUs in 15 hospitals were recorded. Each case was evaluated locally postmortem with respect to medical suitability to organ donation. A total of 1655 deaths were recorded, corresponding to 504 deaths per million population per year (PMP). Median age was 70 years (0 to 99 years), 52% were more than 70 years, and 22% more than 80 years of age. The cause of death was cerebral lesion in 18% of the cases (neurosurgical ICUs: n ϭ 182; ICUs: n ϭ 110). By thorough medical record examination, the number of potential donors was estimated to be 169, corresponding to 51 PMP. The cause of death was cerebral lesion in 96% of the potential donors. Organ donation was performed in 43 cases (32 from neurosurgical ICUs and 11 from ICUs) or 13.1 PMP. Thus, 25% of the potential became organ donors. The major reason for nondonation was refusal from the relatives. Out of 127 questioned, the relatives refused in 62 cases (49%). By comparison, 74% of the general Danish population are willing to donate organs after death.
    [Show full text]
  • A Comparison of Sexual Behaviour and Attitudes of Healthy Adolescents In
    Population Health Metrics BioMed Central Research Open Access A comparison of sexual behaviour and attitudes of healthy adolescents in a Danish high school in 1982, 1996, and 2001 Ida Kangas*1, Berit Andersen1,2, Christine A McGarrigle3 and Lars Østergaard1 Address: 1Research Unit Q, Department of Infectious Diseases, Skejby Sygehus, Aarhus University Hospital, Brendstrupgaardsvej 100, Skejby Sygehus, DK-8200 Aarhus N, Denmark, 2Research Unit and Department of General Practice, University of Aarhus, Vennelyst Boulevard 6, DK- 8000 Aarhus C, Denmark and 3HIV/STI Division, Health Protection Agency, Communicable Disease Surveillance Centre, 61 Colindale Ave, London NW9 5EQ, United Kingdom Email: Ida Kangas* - [email protected]; Berit Andersen - [email protected]; Christine A McGarrigle - [email protected]; Lars Østergaard - [email protected] * Corresponding author Published: 23 March 2004 Received: 18 July 2003 Accepted: 23 March 2004 Population Health Metrics 2004, 2:5 This article is available from: http://www.pophealthmetrics.com/content/2/1/5 © 2004 Kangas et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Abstract Aim: To assess changes in sexual behaviour among students at a high school in Denmark from 1982 to 2001. Methods: An anonymous self-administered questionnaire was used to compare data from three identical cross-sectional surveys performed in 1982, 1996, and 2001. Results: Girls: More girls reported their first sexual intercourse before their 16th birthday in 2001 (42%) than in 1996 (29%) In 1982 it was also 42% (Chi-square for trend: p = 0.003).
    [Show full text]
  • Moderate Alcohol Intake During Pregnancy and the Risk of Stillbirth and Death in the First Year of Life
    American Journal of Epidemiology Vol. 155, No. 4 Copyright © 2002 by the Johns Hopkins Bloomberg School of Public Health Printed in U.S.A. All rights reserved Alcohol in Pregnancy and Stillbirth/Infant Death Risk Kesmodel et al. Moderate Alcohol Intake during Pregnancy and the Risk of Stillbirth and Death in the First Year of Life Ulrik Kesmodel,1 Kirsten Wisborg,1,2 Sjúr∂ur Fró∂i Olsen,3 Tine Brink Henriksen,1,2 and Niels Jørgen Secher1 The authors evaluated the association between alcohol intake during pregnancy and risk of stillbirth and infant death in a cohort of pregnant women receiving routine antenatal care at Aarhus University Hospital (Aarhus, Denmark) between 1989 and 1996. Prospective information on alcohol intake, other lifestyle factors, maternal characteristics, and obstetric risk factors was obtained from self-administered questionnaires and hospital files, Downloaded from and 24,768 singleton pregnancies were included in the analyses (116 stillbirths, 119 infant deaths). The risk ratio for stillbirth among women who consumed ≥5 drinks/week during pregnancy was 2.96 (95% confidence interval: 1.37, 6.41) as compared with women who consumed <1 drink/week. Adjustment for smoking habits, caffeine intake, age, prepregnancy body mass index, marital status, occupational status, education, parity, and sex of the child did not change the conclusions, nor did restriction of the highest intake group to women who consumed 5–14 drinks/week (risk ratio = 3.13, 95% confidence interval: 1.45, 6.77). The rate of stillbirth due to fetoplacental http://aje.oxfordjournals.org/ dysfunction increased across alcohol categories, from 1.37 per 1,000 births for women consuming <1 drink/week to 8.83 per 1,000 births for women consuming ≥5 drinks/week.
    [Show full text]
  • Danish University Colleges the Meaningfulness of Participating In
    Danish University Colleges The meaningfulness of participating in support groups for informal caregivers of older adults with dementia Lauritzen, Jette; Pedersen, Preben Ulrich; Bjerrum, Merete Bender Publication date: 2014 Link to publication Citation for pulished version (APA): Lauritzen, J., Pedersen, P. U., & Bjerrum, M. B. (2014). The meaningfulness of participating in support groups for informal caregivers of older adults with dementia. Abstract from PHD Day Health, Aarhus, Denmark. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Download policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Download date: 05. Oct. 2021 PROGRAMME & ABSTRACTS 24 JANUARY 2014 GRADUATE SCHOOL OF HEALTH AARHUS UNIVERSITY PHD DAY 2014 PROGRAMME 8.30 Welcome by Allan Flyvbjerg Dean, Aarhus University, Faculty of Health Sciences 8.40 Welcome by Nis Pedersen Jørgensen Chairman of the
    [Show full text]
  • Analysis of 1 Year Virtual Histology Changes in Coronary Plaque Located Behind the Struts of the Everolimus Eluting Bioresorbable Vascular Scaffold
    Int J Cardiovasc Imaging (2012) 28:1307–1314 DOI 10.1007/s10554-011-9981-4 ORIGINAL PAPER Analysis of 1 year virtual histology changes in coronary plaque located behind the struts of the everolimus eluting bioresorbable vascular scaffold Salvatore Brugaletta • Josep Gomez-Lara • Hector M. Garcia-Garcia • Jung Ho Heo • Vasim Farooq • Robert J. van Geuns • Bernard Chevalier • Stephan Windecker • Dougal McClean • Leif Thuesen • Robert Whitbourn • Ian Meredith • Cecile Dorange • Susan Veldhof • Richard Rapoza • John A. Ormiston • Patrick W. Serruys Received: 4 July 2011 / Accepted: 14 November 2011 / Published online: 23 November 2011 Ó The Author(s) 2011. This article is published with open access at Springerlink.com Abstract Serial intravascular ultrasound virtual his- dedicated software, the composition of the PBS was tology (IVUS-VH) after implantation of metallic stents analyzed in all patients from the ABSORB Cohort B2 has been unable to show any changes in the compo- trial, who were imaged with a commercially available sition of the scaffolded plaque overtime. The everol- IVUS-VH console (s5i system, Volcano Corporation, imus-eluting ABSORB scaffold potentially allows for Rancho Cordova, CA, USA), immediately post- the formation of new fibrotic tissue on the scaffolded ABSORB implantation and at 12 month follow-up. coronary plaque during bioresorption. We examined Paired IVUS-VH data, recorded with s5i system, were the 12 month IVUS-VH changes in composition of the available in 17 patients (18 lesions). The analysis plaque behind the struts (PBS) following the implan- demonstrated an increase in mean PBS area (2.39 ± tation of the ABSORB scaffold. Using IVUS-VH and 1.85 mm2 vs.
    [Show full text]
  • Six Novel Mutations in the Arginine Vasopressin Gene in 15 Kindreds
    European Journal of Human Genetics (2004) 12, 44–51 & 2004 Nature Publishing Group All rights reserved 1018-4813/04 $25.00 www.nature.com/ejhg ARTICLE Six novel mutations in the arginine vasopressin gene in 15 kindreds with autosomal dominant familial neurohypophyseal diabetes insipidus give further insight into the pathogenesis Jane H Christensen1, Charlotte Siggaard2, Thomas J Corydon3, Luisa deSanctis4, Laszlo Kovacs5, Gary L Robertson6, Niels Gregersen7 and Sren Rittig*,2 1Pediatric Research Laboratory, Aarhus University Hospital, Skejby Sygehus, Aarhus, Denmark; 2Department of Pediatrics, Aarhus University Hospital, Skejby Sygehus, Aarhus, Denmark; 3Department of Human Genetics, University of Aarhus, Aarhus, Denmark; 4Department of Pediatrics, University of Torino, Torino, Italy; 5Comenius University Medical School, Comenius University, Bratislava, Slovakia; 6Department of Medicine, Northwestern University Medical School, Chicago, IL, USA; 7Research Unit for Molecular Medicine, Aarhus University Hospital, Skejby Sygehus, Aarhus, Denmark Autosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI) is caused by postnatal arginine vasopressin (AVP) deficiency resulting from mutations in the AVP gene encoding the AVP pre- prohormone. To advance the understanding of adFNDI further, we have searched for mutations in the AVP gene in 15 unrelated kindreds in which diabetes insipidus appeared to be segregating. In nine kindreds, seven different previously described mutations were identified. In each of the other six kindreds, unique novel mutations were identified. Two of these (225A4G and 227G4A) change a nucleotide in the translation initiation codon of the signal peptide, whereas the other four (1797T4C, 1884G4A, 1907T4G, and 2112C4G) predict amino-acid substitutions in the neurophysin II moiety of the AVP prohormone, namely V67A (NP36), G96D (NP65), C104G (NP73), and C116W (NP85).
    [Show full text]
  • Use of Medical Databases in Clinical Epidemiology
    Use of Medical Databases in Clinical Epidemiology Second edition Henrik Toft Sørensen Tina Christensen Hanne Kjeldahl Schlosser Lars Pedersen, eds. Department of Clinical Epidemiology Aarhus University Hospital Denmark 2009 SUN-TRYK, Aarhus Universitet ISBN 978-87-992649-1-9 Editors Henrik Toft Sørensen Tina Christensen Hanne Kjeldahl Schlosser Lars Pedersen Contributors Alma Becic Pedersen Anna Lamberg Anne Nakano Anne-Mette Bay Bjørn Annette Thurah Annette Østergaard Jensen Charlotte Gjørup Pedersen Christian Fynbo Christiansen Christiane Gasse Daniel Buck Deirdre Cronin-Fenton Ellen Margrethe Mikkelsen Estrid Muff Munk Heidi Larsson Henriette Thisted Horsdal Jette Brommann Kornum Karin Biering Lars Haukali Omland Lene Hjerrild Iversen Marie Louise Tørring Merete Lund Hetland Mette Nørgaard Morten Madsen Nicolai Lohse Niels Henrik Hjøllund Nina Weis Peter Jepsen Pia Wogelius Reimar Wernich Thomsen Sandra Kruchov Thygesen Steffen Christensen Søren Friis Søren Paaske Johnsen Timothy Lash Vera Ehrenstein Vivian Langagergaard Preface to second edition In 2008, Department of Clinical Epidemiology launched a report for our researchers and international collaborators with the aim of providing an overview of the databases and registries most commonly used in Department of Clinical Epidemiology. The first edition was a tremendous success and has already been printed in 500 samples. Therefore we have extended the first edition by including more descriptions of databases, adding references and revising the text. I would like to thank all the wonderful colleagues at Department of Clinical Epidemiology and our collaborators in the efforts to provide a second edition of this book. It is still our intention to regularly update the book and we will be happy to receive suggestions and feedback to continuously improve the book.
    [Show full text]
  • Role of Common Gene Variations in the Molecular Pathogenesis of Short-Chain Acyl-Coa Dehydrogenase Deficiency
    0031-3998/01/4901-0018 PEDIATRIC RESEARCH Vol. 49, No. 1, 2001 Copyright © 2001 International Pediatric Research Foundation, Inc. Printed in U.S.A. ARTICLES Role of Common Gene Variations in the Molecular Pathogenesis of Short-Chain Acyl-CoA Dehydrogenase Deficiency MORTEN JUHL CORYDON, JERRY VOCKLEY, PIERO RINALDO, WILLIAM JAMES RHEAD, MARGRETHE KJELDSEN, VIBEKE WINTER, CHARLES RIGGS, DUSICA BABOVIC-VUKSANOVIC, JAN SMEITINK, JAN DE JONG, HARVEY LEVY, ADRIAN CLIVE SEWELL, CHARLES ROE, DIETRICH MATERN, MAJED DASOUKI, AND NIELS GREGERSEN Research Unit for Molecular Medicine, Aarhus University Hospital and Faculty of Health Sciences, Skejby Sygehus, 8200 Aarhus N, Denmark [M.J.C., M.K., V.W., N.G.]; Department of Medical Genetics, Mayo Clinic and Foundation, Rochester, MN 55905, U.S.A. [J.V., D.B-V.]; Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN 55905, U.S.A. [P.R.]; Department of Pediatrics, University of Iowa, Iowa City, IA 50011, U.S.A. [W.J.R.]; Human Performance Laboratory, University of Arkansas, Fayetteville, AR 72701, U.S.A. [C.R.]; University Children’s Hospital, Department of Metabolic Diseases, 6500 HB Nijmegen, The Netherlands [J.S., J.D.J.]; Division of Genetics, Children’s Hospital, Boston, MA 02115, U.S.A. [H.L.]; University Children’s Hospital, 60596 Frankfurt am Main, Germany [A.C.S.]; Institute of Metabolic Disease, Dallas, TX 75226, U.S.A. [C.R.]; Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, Durham, NC 27708, U.S.A. [D.M.]; Children’s Mercy Hospital, Kansas City, MO 64108, U.S.A. [M.D.] ABSTRACT Short-chain acyl-CoA dehydrogenase (SCAD) deficiency is considered a in 10 patients with ethylmalonic aciduria and diagnosed with SCAD defi- rare inherited mitochondrial fatty acid oxidation disorder.
    [Show full text]