Physics of Living Systems Arun Paramekanti Associate Professor

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Physics of Living Systems Arun Paramekanti Associate Professor Physics of Living Systems Arun Paramekanti Associate Professor, Physics Reductionist viewpoint does not imply we can construct macroscale physics from knowledge of microscale physics Basis of condensed matter physics, complexity, physicists’ attempts to understand biological systems Marian Smoluchowski Ludwig Boltzmann Max Delbruck Erwin Schrodinger Dorothy Hodgkin Rosalind Franklin Francis Crick Physics and Biology Max Delbruck Among the earliest “biophysicists” who converted many physicists to studying problems of biological interest Nobel Prize in Medicine for work (with Salvador Luria) showing that immunity of bacteria to drugs is caused by random mutations rather than adaptation Ludwig Boltzmann Thermodynamics and statistical physics Atoms do exist Kinetic theory of gases Founder of statistical physics Randomness Marian Smoluchowski Albert Einstein Studied Brownian motion and provided a theoretical understanding of diffusion - a process of great biological importance as we will see Erwin Schrodinger Quantum Physics Theory of Quantum Mechanics (Nobel Prize, Physics) Author of an influential essay “What is Life?” inspired by Max Delbruck Dorothy Hodgkin Physics Tools [X-ray diffraction] Applied X-ray crystallography to study an amazing variety of biological molecules - Penicillin, Vitamin B12, Insulin (Nobel Prize in Chemistry) Rosalind Franklin Francis Crick Worked on the structure of DNA PERIODICITY Regular in time Regular in space Oscillations Embryogenesis RANDOMNESS Body Clocks Light and Sound Quantum mechanics Probability Chance Molecular Events Genetics Epidimiology Physics Tools Thermodynamics X-ray diffraction (Crystal structure) Nuclear magnetic resonance (MRI) When and Where and Why Lectures When: Tue 2pm, Thu 2pm Where: MP134 Labs/Tutorials When: Fri 2-4pm (alternate 1 or 2 hrs) Where: MP238 Books Textbook Biological physics: Energy, Information, Life Philip Nelson (W. H. Freeman) Reference Random Walks in Biology, H. Berg Evaluation Tutorials and Labs: 30% Homework assignments: 20% Midterm: 25% Final Exam: 25% H1N1 preparedness http://www.preparedness.utoronto.ca If unwell, must get doctor’s note or check how to access the “Absence Registry” for any missed term work or exams. If you are at home on account of illness but wish to send in completed term work, you can scan and email it to the TA. Email: Please put “PHY231” in subject.
Recommended publications
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    The Global and the Local: The History of Science and the Cultural Integration of Europe. nd Proceedings of the 2 ICESHS (Cracow, Poland, September 6–9, 2006) / Ed. by M. Kokowski. Bronisław Średniawa * Scientific contacts of Polish physicists with Albert Einstein Abstract Scientific relations of Polish physicists, living in Poland and on emigration,with Albert Einstein, in the first half of 20th century are presented. Two Polish physicists, J. Laub and L. Infeld, were Einstein’s collaborators. The exchange of letters between M. Smoluchowski and Einstein contributed essentially to the solution of the problem of density fluctuations. S Loria, J. Kowalski, W. Natanson, M. Wolfke and L. Silberstein led scientific discussions with Einstein. Marie Skłodowska-Curie collaborated with Einstein in the Commission of Intelectual Cooperation of the Ligue of Nations. Einstein proposed scientific collaboration to M. Mathisson, but because of the breakout of the 2nd World War and Mathisson’s death their collaboration could not be realised. Contacts of Polish physicists with Einstein contributed to the development of relativity in Poland. (1) Introduction Many Polish physicists of older generation, who were active in Polish universities and abroad before the First World War or in the interwar period, had personal contacts with Einstein or exchanged letters with him. Contacts of Polish physicists with Einstein certainly inspired some Polish theoreticians to scientific work in relativity. These contacts encouraged also Polish physicists to make effort in the domain of popularization of relativity and of the progress of physics in the twenties and thirties. We can therefore say that the contacts of Polish physicists with Einstein contributed to the development of theoretical physics in Poland.
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