IN FOCUS Vol 5 Issue 3 August 2011 Message from the Chair The start of the many faculty candidates will be several Department of Pathology Inside this issue: new school year visiting UAB and I hope that you will investigators are tentatively Faculty Profile: Dr. Hébert- 2-3 once again brings be able to attend as many candi- scheduled to move this fall into Magee many new faces date seminars as possible. renovated laboratory space in the to the Department Wallace Tumor Institute. These APC Teaching Awards 3-4 of Pathology. In A number of construction and new facilities will permit further Where Are They Now? 4 addition to the building renovation projects are expansion of cancer related re- Spotlight on Administration 5 annual influx of new residents, underway in the department and search in our department and help fellows and graduate students, several are nearing completion. I us to recruit additional outstanding New Changes in HIT 5-6 several new faculty members will am optimistic that by the time you clinicians and investigators to UAB. 6-7 From the Chief Residents be joining various divisions over read the next quarterly newsletter, From the Graduate Students 7-8 the next few months. Look for new the Anatomic Pathology Division faculty profiles in this and upcom- faculty, staff, and services cur- Best wishes, New Faculty Recruits 8 ing issues of our newsletter. Our rently housed in the Kracke Build- Kevin A. Roth, M.D., Ph.D. Pathology Grant Awards 9 aggressive recruitment strategy ing will all be moved to newly com- will continue through the fall as pleted facilities in PD6A. Similarly,

Faculty Profile: Majd Zayzafoon, M.D., Ph.D.

Majd Zayza- by a fellowship in Gastroenterology osteoblast differentiation and bone foon, MD, PhD, at Preston Hospital, Tyne & Wear, formation. He has made significant is an Associ- England. Majd then moved to the contributions to the elucidation of ate Professor United States and joined the Physi- the role of Ca2+ signaling through Pathology In Focus in the Depart- ology Doctoral Program at Michi- the activation of calmodulin- Editorial Committee ment of Pa- gan State University, where he dependent protein kinase II and the Editor-in-Chief: thology. He earned his Ph.D. degree. In 2002 nuclear factor of activated T-cells, C. Bruce Alexander, M.D. serves as the Director of the UAB- he moved to UAB as a post- with a particular emphasis on the Center for Metabolic Bone Disease doctoral fellow in the Division of on the regulation of osteoblast R. Pat Bucy, M.D., Ph.D. (UAB-CMBD), is Co-Director of the Molecular and Cellular Pathology, proliferation and differentiation. Rakesh Patel, Ph.D. NIH P30 UAB Core Center for Basic Department of Pathology. Since His current research is focused on Walter C. Bell, M.D. and Translational Skeletal Re- that time Majd has moved rapidly identifying the roles of calcium, Marisa B. Marques, M.D. search, and is PI of the NIH T32 through the ranks, being promoted calmodulin, and related protein Majd Zayzafoon, M.D., Ph.D. Comprehensive Training Program to Associate Professor in 2009. kinases and phosphatases in os- Angie Schmeckebier in Bone Biology and Disease. Majd He is also currently enrolled in the teoporosis, osteosarcoma and Margaret Dotzler Zayzafoon was born in Birmingham MBA Graduate Program at the UAB prostate cancer bone metastasis. and grew up in Norwich, England. School of Business where he is A combination of biochemistry, cell He went to medical school at Da- expected to obtain his MBA in 2012. biology, and molecular biology Dept. of Pathology Website: mascus University, Syria where he Majd’s research program is fo- techniques are used in his labora- www.path.uab.edu obtained his MD degree. After cused on his long-standing interest tory to elucidate the critical signal graduation, he completed his resi- in the role of calcium signaling in transduction pathways involved in Newsletter E-Mail: dency in Internal Medicine followed the transcriptional regulation of [email protected] Cont’d...

Pathology In Focus Page 2

Majd Zayzafoon Cont’d: each of these diseases, with the facilitate the translational re- In 2009 Majd was elected by the ultimate goal of modulating key search efforts of the Center for JHS faculty to UAB Faculty Senate, signal transduction pathways as Metabolic Bone Disease which he and in 2010 he received a Com- potential new avenues for therapy. directs. The goal of the CMBD is to mendation Award for Outstanding provide a broad-based multidisci- Service to the Senate. He was Majd has also received the prestig- plinary research, training and Chair of the Faculty Senate Cur- ious Harold Frost and John Haddad service focused on metabolic bone riculum & Research Committee Young Investigator awards from disease; with the mission to help from 2010-2011 and is now Chair of the American Society for Bone and catalyze and integrate educational, the newly created Faculty Senate Mineral Research (ASBMR), and he clinical and basic research activi- Research Committee for 2011-2012. was recently elected as executive ties. The membership of the CMBD Majd is also Founder and President board member of the AIMM/ currently includes 93 faculty from of Novicure , which is ASBMR. Majd’s clinical background 9 schools and 29 departments at a biotech company focused on coupled with his in-depth basic and UAB. drug discovery for prostate cancer translational research experience bone metastasis. provide the expertise necessary to

Faculty Profile: Shantel Hebert-Magee, M.D.

Dr. Shantel note characteristics which distin- she was told the favorite Creole Hébert-Magee guish them from other hereditary statement “et toi”, French literally has recently and sporadic renal neoplasms. For for “and you”, but used in bayou joined the UAB this work, she was awarded the territory to mean “your turn.” Cytopathology Ultrastructural Pathology Award at When her turn came, Dr. Hébert- faculty as a new the 2010 USCAP. Last year, Dr. Magee realized that she wanted to member. She is a native of Louisi- Hébert-Magee came to UAB as a make an impact in minority health, ana and attended medical school at Cytopathology fellow after her health disparities, and health initia- Georgetown University School of previous mentor at Georgetown, tives for the underserved. As an Medicine. She continued on at Dr. Mary Sidawy, highly recom- undergraduate Howard Hughes Georgetown University Hospital mended Drs. Isam Eltoum and An- scholar, she investigated the ef- completing a combined residency in dra Frost as experts in the field. fects of 7,12- Anatomic and Clinical Pathology in dimethylbenzanthracene on rat 2009, during which time she had As a child Dr. Hébert-Magee was mammary glands and the estrous been recognized as resident of the taught by her famille to make an cycle; this model paralleled inner- year and served as chief resident. impact. She learned of the legacy city carcinogenic exposure and Subsequently, Dr. Hébert-Magee of her family, having a great-great breast cancer risks for African went to the National Cancer Insti- -great grandfather who was an American women. In addition, she tute officer in the Louisiana 1st Native spent a summer as a Harvard- and completed a Translational Guard the first colored regiment in SHURP scholar, under the direction Surgical Pathology fellowship under the Civil War, whose family later of Dr. Michael Starnbach, of the the directorship of Dr. Maria Me- expatriated to Haiti and France for Department of Microbiology and rino. While at the NCI, Dr. Hébert- lack of rights for blacks. Upon her Molecular Genetics at Harvard Magee studied the ultrastructural family’s return to the states, they Medical School, investigating CD8+ features of renal tumors in patients emphasized education, culture and response to the pathogen C. with Birt-Hogg-Dubé syndrome and community. It wasn’t long before Cont’d... Pathology In Focus Page 3

Shantel Hébert-Magee Cont’d... trachomatis, a prevalent cause of submitted two grants directed at In her spare time, Dr. Hébert-Magee sexually transmitted disease and minority health disparities, has two enjoys writing Creole literature, blindness in developing countries. papers under review, and two painting, spending time with her She was also one of the first recipi- abstracts accepted for the ASC family, and her Pomeranian, Saint It wasn’t long before ents of the NIH-UGSP scholarship conference in November. She is (named after the New Orleans Saints, she was told the and worked with Dr. Michael A. particularly excited as to how her of course). She also volunteers with favorite Creole Rogawski at the Epilepsy Research projects in HPV oral pharyngeal medical school applicants, always statement “et toi”, Branch of National Institute of Neu- carcinoma and Triple Negative leaving them with two words to French literally rological Disorders and Stroke Breast Cancer in African Ameri- stimulate impact, et toi. investigating the inhibitory effects cans may serve as a nidus to other for “and you”, but of finasteride on allopregnanolone studies. She is very elated to have used in bayou and the therapeutic implications in started her professional career at territory to mean women with catamenial epilepsy. UAB. “your turn.” Dr. Hébert-Magee has recently

APC Distinguished Teaching Awards:

gram direc- leadership positions in many na- tors tional and international educational (PRODS,) organizations. established annual Distin- Dr. Anderson has received multiple guished "Advancing the Field of Pathology Teaching Through Computer " Awards in awards and "Best Departmental Undergradu- Website" awards from the Advanc- ate ing Pathology Informatics, Imaging Medical and the Internet Group (APIII). Last Two top educators from the UAB Education and Graduate Medical year he was awarded the Alpha Department of Pathology have Education. One award in each cate- Omega Alpha Honor Society’s received meritorious awards from gory is granted to medical educa- Robert J. Glaser Distinguished the Association of Pathology Chairs tors in pathology who demonstrate Teaching Award. His Pathology at the association’s annual meeting significant contributions at local, Education Instructional Resource in July 2011 in Monterey, California. regional, and national levels in (PEIR) website is an internationally C. Bruce Alexander, MD, received either undergraduate or graduate acclaimed educational resource. the 2011 Distinguished Teaching medical education. Award in Graduate Medical Educa- Dr. C. Bruce Alexander, the recipi- tion; and Peter G. Anderson, DVM, Dr. Peter G. Anderson, the recipi- ent of the graduate teaching PhD, received the 2011 Distin- ent of the undergraduate teaching award, is Professor and Vice Chair guished Teaching Award in Under- award, is Professor of Pathology in the Department of Pathology at graduate Medical Education. and Director of Pathology Under- UAB School of Medicine. In addition, graduate Education at UAB School he is the Pathology Residency In 2010, the Association of Pathol- of Medicine. He is very active in Program Director and Section ogy Chairs, along with their sec- educational pursuits, most notably Head of Autopsy Pathology. Dr. tions for medical student educa- in using to enhance Alexander is recognized nationally tors (UMEDS) and residency pro- teaching and learning. He holds for his contributions to graduate medical education. He was a Pathology In Focus Page 4

APC Teaching Awards Cont’d...

Board of Directors of the ASCP, the top program directors in resi- the American Pathology Founda- dency education. It is given to tion, the National Residency Match those finding innovative ways to Program (NRMP), and the national teach residents. He has written a Alpha Omega Alpha Honor Society. number of papers on graduate Dr. Alexander is currently presi- medical education and was a par- dent-elect of the American Society ticipating author on authoritative for Clinical Pathology, and will papers on curricula for medical assume the presidency of that education and graduate medical organization in October of this education. year.

Dr. Alexander was the recipient of the Parker Palmer “Courage to founding member of the PRODS Teach” Award in 2002. This award, Section of the APC; and is on the given by the ACGME, is specific for

Where Are They Now?

Dr. Adam B. representing the Pathology De- cancer chemoprevention. Keeton ob- partment. tained his Dr. Keeton is a member of the Ph.D. degree After obtaining his Ph.D., Dr. American Association for Cancer in Pathology Keeton was a Postdoctoral Fellow Research, the Society for Bio- from UAB in at UAB in 2004, and a Cell Biology molecular Sciences, and the 2003, after and Postdoctoral American Society of Pharmacology obtaining his BS degree in Natural Fellow at the Southern Research & Experimental Therapeutics. Science (Cum Laude) from UAB in Institute in Birmingham in 2005. From 2007 to the present, he has 1994. From 1994 to 1996, Dr. From 2004-2006, he was a mem- delivered a lecture, “High Content Keeton was an NIH Pre-Doctoral ber of the Executive Board of the Screening for Drug Discovery,” in Fellow, and from 1998-1999, he had UAB Postdoctoral Association and the Vocabulary in Drug Discovery a fellowship sponsored by the chairman of the “Beyond the course within the UAB Hughes Med Diabetes Trust Fund Boshell Schol- Bench” committee. -Grad Fellowship Program. arship in Medicine. During his Ph.D. studies in the UAB Pathology In 2006, Dr. Keeton accepted a Dr. Keeton has many fond memo- Graduate Program, Dr. Keeton was staff scientist position in the assay ries of his colleagues and friends guided and instructed in Dr. Jo- development group at Southern in the Pathology graduate program seph L. Messina’s laboratory, Research Institute, as part of the and especially the guidance where his research focused on NIH Roadmap High Throughput of his mentor, Dr. Joseph Messina. insulin signal transduction path- Screening program. In 2010, he He resides in Gardendale, Alabama. ways and insulin regulated gene was promoted to Research Biolo- expression. From 1999-2003, he gist at Southern Research. At served as Senator to the UAB present, he is part of a drug dis- Graduate Student Association, covery group involved in elucidat- ing certain mechanisms of colon Pathology In Focus Page 5

Spotlight on Administration—Karen Lewis:

Karen Lewis is diology, where she learned medical Program requirements for certifica- the Residency terminology and had a lot of direct tion of the program are always Program patient contact, which she found changing – so it’s critical to keep up Coordinator very rewarding. She transferred with the changes and remain in for Pathology. into the Department of Pathology in compliance. She says that the best She manages 1997. When first applying for the part of her job is the residents the day-to- position, Karen recalls that she did themselves. They amaze her with day opera- not even know what a resident was - their hard work, devotion and tal- tions of the - she had to read up on it. ents, both in the medical profession Program, under the direction of Dr. and outside of it. Bruce Alexander. Karen’s back- Karen started the new job in Sep- ground was not originally in the tember, when applications were Karen graduated from the University medical field. From 1976 to 1990 she flooding in, close to 1,000 that year! of Montevallo in 1976 with a BA in worked in administrative support She helped Dr. Alexander review the History and a minor in Office Admini- positions at Alabama Power . After applications, and then began sched- stration. She is married to Earl that, she took a break to be a stay- uling interviews. Each Interview day Lewis, and they reside in Bluff Park at-home mom for a few years to her started with breakfast and went all along with Callie, their calico cat. young son, Josh. In 1993 she reen- day until 5:00 – sometimes later. Her grown son Josh works for Con- tered the work force as the Execu- “At the end of each day, I was ex- federate Motor Company in Birming- tive Assistant to the Director of the hausted. But all this work paid off ham, where he designs and builds Birmingham Festival of the Arts. big time. In March, eight outstanding high-end and unique motorcycles. new residents were signed on! “ Karen and Earl love to entertain. Karen came to UAB In 1995, accept- Karen reflects that being a Program Their ongoing hobby and endless ing a position in Interventional Car- Coordinator is a challenging job. project is their home.

New changes to HIT antibody testing protocols aim to reduce misdiagnosis of HIT in the UAB patient population: Heparin-Induced patients, low molecular weight hepa- Making a clinical diagnosis of HIT is Thrombocytopenia rins (i.e. enoxaparin) still have a often complex, especially in patients (HIT) is a severe small potential for inducing HIT with other confounding medical condi- and potentially life- antibodies. tions that also cause thrombocyto- threatening compli- penia and/or thrombosis. Two types cation of heparin HIT is caused by an immune response of laboratory assays for detecting HIT therapy. In the classical presenta- against heparin and Platelet Factor-4 antibodies are available. At UAB, as in tion of HIT, thrombocytopenia devel- (PF4) complexes. Heparin binds to most academic medical centers, we ops 5-14 days after initiating heparin PF4, a chemokine released from acti- offer an immunoassay (ELISA) which detects antibodies that bind to hepa- therapy. Thrombocytopenia is de- vated platelets, causing a conforma- rin:PF4 complexes. This assay is not fined as a platelet count of <150 tional change resulting in a novel 3 epitope that is recognized by the technically demanding and results are x10 /mL or a 30-50% fall from the available relatively quickly. Although baseline platelet level. Patients with patient’s immune system. Antibodies against this epitope are formed and the sensitivity of this assay is near HIT may develop venous or arterial have the potential to bind to hepa- 100% (meaning a negative test thromboses up to 30 days after rin:PF4 complexes and to IgG recep- strongly argues against a diagnosis of cessation of heparin and therefore tors on platelets, causing activation of HIT), its specificity is only ~50%. A must remain on alternative antico- platelets and increased risk for positive ELISA result is a poor predic- agulation for up to six weeks after thrombosis. tor of a true HIT diagnosis. This assay diagnosis. Although unfractionated will also detect non-pathogenic hepa- heparin poses the greatest risk to rin:PF4 antibodies as well as some Cont’d…. Pathology In Focus Page 6

New Changes to HIT Cont’d... unrelated antibodies (e.g. lupus agnosed with HIT. Why is this dan- 8:2642-50). These scoring systems anticoagulant, anti-bovine protein gerous? A diagnosis of HIT forever were validated in our prospective antibodies, immune complexes). A changes anticoagulation practices study of the HIT ordering practices functional assay that detects patho- for the patient. Current guidelines of UAB physicians. If either probabil- genic HIT antibodies is available as a state that patients who have a diag- ity score shows an intermediate risk send-out test. The Platelet 14C- nosis of HIT should not have future for HIT, the HIT antibody assay re- Serotonin Release Assay (SRA) is heparin exposure unless undergoing quest will be approved. If both scor- considered the “gold standard” for cardiopulmonary bypass surgery ing systems show a low risk of HIT, HIT antibody testing. Unfortunately, (Chest 2008;133;340-380). In addi- the HIT antibody request will be this assay is very technically de- tion, because of the prolonged risk canceled. A copy of our scoring manding and is only offered at highly of thrombosis, patients with a HIT sheet can be viewed specialized reference laborato- diagnosis, who are often thrombocy- here. Specimens with positive HIT ries. The turn-around time for the topenic and have other bleeding antibody will be sent out for the SRA can be as long as one week. complications, must be anticoagu- Serotonin Release Assay (SRA) to lated for up to 6 weeks after diagno- determine the antibody function. We recently completed a prospec- sis. Results will be available as an inter- tive study on the HIT antibody order- pretive report. We strongly recom- ing practices of UAB physicians. We In an effort to improve patient mend evaluating your patients using found that over 50% of HIT antibody safety by reducing the risk of HIT these criteria prior to ordering the test requests are for patients with a misdiagnosis at UAB, Pathology HIT antibody test. If there are any very low clinical probability of hav- residents and attendings from the questions, call the laboratory at 934 ing HIT. In fact, 15% of orders were Coagulation Service will review all -1045 and ask for the Pathology placed on patients with no history of HIT antibody orders for appropriate- resident on call. heparin exposure! Given the low ness. Patients will be evaluated specificity of the HIT antibody ELISA using two HIT pre-test probability Jill Adamski, MD, PhD assays and the ordering practices at scoring systems: The Warkentin’s —This story was reprinted from UAB, it is clear that we have created 4T’s and the HIT Expert Probability Synopsis (http:// an environment that places our Score (J Thromb Haemost 2006; 4: www.oneuabmedicine.org/UAB1/ patients at great risk of being misdi- 759–65; J Thromb Haemost 2010; news/s-hit)

From the Chief Residents: We welcome the new residents and have worked hard and will do well! Meeting will be held on October 19- fellows who joined our program in 22 in Las Vegas, NV. Rong Li will July. We are excited you are here National Meetings: present the posters: “A Transloca- and look forward to a great year! College of American Pathologists tion-associated Renal Carcinoma (CAP)-The annual CAP meeting will Resembling Hybrid Oncocytic Tu- Emily Gorman and be held on September 11-14 in mor,” and “Extramedullary Hema- Amberly Nunez Grapevine, TX. Jie Xu will present topoiesis: An Unusual Finding in Chief Residents, 2011-2012 the poster “Metastatic Renal Cell Subdural Hematomas.” Faculty Carcinoma Presenting as Gastric mentors are Dr. Shi Wei and Drs. Boards: Polyps.” Faculty mentor was Dr. Vishnu Reddy and Cheryl Palmer, Congratulations to those residents Shi Wei. respectively. who recently passed their boards! Best wishes to those residents American Society for Clinical Pa- taking board exams this fall. You thology— The Annual ASCP Pathology In Focus Page 7

From the Chief Residents Cont’d:

American Society of Dermatopa- Strategies.” Faculty mentor was going Reception: thology (ASDP)-The Annual ASDP Dr. Cheryl Palmer. Primary faculty, fellows, and resi- meeting will be held on October 20 dents attended the 2011 Outgoing -23 in Seattle, WA. Caitlin Committees: Reception on Thursday, May 12, at Halverson will present the poster Alex Hanna has been elected to Vestavia Hills Country Club. Resi- “Cutaneous Reactive Angiomatosis serve a one- year term as the UAB dents and fellows finishing their Associated with End-Stage Renal Program liaison for ASCP begin- training received certificates of Disease.” Faculty mentor was Dr. ning in October. Taylor Deal is completion. Awards were pre- Aleodor Andea. Taylor Deal will joining Johnny Ross on the UAB sented to Emily Gorman (Jay M. present the poster “Subcutaneous House Staff Council starting this McDonald Award for Excellence in Sweets Syndrome in a Leukemic Fall. Laboratory Medicine Presentation), Patient: Case Report of a Rare Johnny Ross (Kracke Award for Entity with Emphasis on the Differ- New Appointments: Best Presentation in Anatomic ential Diagnosis.” Faculty mentor Thuy Nguyen, Zhiyong Ren, Pathology), and Mark Steciuk was Dr. Aleodor Andea. and Yaolin Zhou have been chosen (Roger Denio Baker Prize in Ana- to serve as our Residency Website tomical Pathology). American Association of Blood Coordinators and will be responsi- Banks (AABB)-The Annual AABB ble for content on the residency meeting will be held on October 22 portion of the UAB Department of -25 in San Diego, CA. Taylor Deal Pathology website. will give an oral presentation enti- tled “Two Novel Jka Alleles in a Jk Congratulations to… (a+b-) Patient with Anti-Jka. …Wei Song, Taylor Deal, Rong Li, and Zhiyong Ren who were Dr. Emily Gorman and Dr. Pat Bucy Society for N euro- (SNO) awarded Adams Grant funding for - The Annual SNO meeting will be research. Faculty mentors held November 17-20 in Orange are Dr. Brandwein-Gensler County, CA. Rob Hackney will (for Wei and Taylor), and Dr. present the poster “Primary Cen- Shi Wei (for Rong and Ren). tral Nervous System Angiosar- coma: Diagnosis and Treatment Resident and Fellow Out-

Dr. Mark Steciuk and Dr. Gene Siegal

From the Graduate Students: Accolades/Awards: Endocrine Society to attend Endo- a UAB DRTC (Diabetes Research crine Trainee Day at ENDO 2011: Training Center) travel award, and Robert N. Bone—received a UAB The Endocrine Society’s 93rd An- presented "6-Mercaptopurine, an Graduate Student Association nual Meeting held June 4-7, 2011 in activator of the orphan nuclear Travel Award to attend the meeting Boston, Massachusetts. As part of receptor NR4A3, modulates glu- of the American Society for Gene this acceptance he received a cose transport in L6 skeletal and Cell Therapy in Seattle, WA. travel award and complimentary muscle cells" at the ADA (free) registration to the meeting. (American Diabetes Association) Ryan Corrick—a graduate and annual meeting in San Diego, MSTP student, was selected by The Qinglan (Helen) Liu— received CA, June 2011. Pathology In Focus Page 8

From the Graduate Students Cont’d:

Shaoning Jiang—Named runner up bowel disease. Scott Tanner—Digestive Diseases in the Young Investigator Award Week, Chicago, IL Decreased regu- competition at the Shock Society Publications/Presentations: latory T cell numbers in the intes- Meeting in June. She received a tine precede the development of travel award for being selected Robert N. Bone—presented the colitis in the FVB.mdr1a-/- mouse. Graduate Program Director: and a cash reward for being the poster entitled "Gene Transfer of runner up. Constitutively Active Akt1 Increases Rakesh Patel, Ph.D. Islet Cell Survival and Prolifera- Angelina Londono Joshi—Elected tion" at the 14th Annual Meeting of Graduate Program Support: president for the UAB Toastmas- the American Society for Gene and ters International Speaking Club. Cell Therapy in Seattle, WA. Cynthia Brown Scott Tanner—was awarded the Melissa Sammy—Krzywanski DM, 934-2848 Marie and Emmett Carmichael Moellering DR, Fetterman JL, Fund for Graduate Students in Dunham-Snary KJ, Sammy MJ and Biosciences. The award is given Ballinger SW. Minireview: the mito- out annually on the basis of aca- chondrial paradigm for cardiovas- demic achievement. Scott will use cular disease susceptibility and the award to continue his work on cellular function: a complementary the role of regulatory T cells in the concept to Mendelian genetics. development of inflammatory Laboratory Investigation 2011; 1-14.

New Pathology Faculty:

Robert Arena, M.D. Shuko Harada, M.D. Laboratory Medicine Anatomic Pathology Instructor Assistant Professor Start Date: 8/8/11 Start Date: 8/15/11

Huma Fatima, M.D. Shantel Hébert-Magee, M.D. Anatomic Pathology Anatomic Pathology Assistant Professor Assistant Professor Start Date: 7/1/11 Start Date: 7/1/11

Pathology In Focus Page 9

Pathology Grant Awards Cont’d:

JONAS ALMEIDA YI-PING LI YANG YANG NIH/Medical Univ. of South Caro- NIH (ARRA) NIH lina Novel RNAi Inhibits Both Inflam- Heperanase Regulation of Osteoly- mation and Bone Resorption in Prognostic Markers in Postopera- sis in Multiple Myelomas If anyone has any news items, tive Acute Kidney Injury Oral Disease $1,380,400 7/08/11-6/30/16 accolades, etc. to be put in the $44,317 1/05/11-1/04/12 $592,990 1/14/11-8/31/11 quarterly newsletter, please YANG YANG send it to the Path In Focus e- JONAS ALMEIDA ROBINNA LORENZ Multiple Myeloma Research Foun- mail address at: ONR/Medical Univ. of South Caro- NIH dation (MMRF) [email protected]. lina Medical Scientist Training Pro- Heparanase as a Therapeutic Tar- Identification and Validation of gram get for Regulation of Myeloma Thank you. Plasma Biomarkers in California $41,663 7/01/11-6/30/15 Bone Disease Sea Lions $200,000 7/01/11-6/30/13 $19,136 1/01/11-5/31/12 RAKESH PATEL American Heart Association (AHA) SCOTT BALLINGER Ole of Endothelial N-glycosylation NIH/Boston University in Mediating Monocyte Adhesion Mitochondrial Dysfunction in the $44,360 7/01/11-6/30/13 Diabetic Endothelium $160,690 4/01/11-2/28/16 KEN WAITES NIH/University of Maryland SCOTT BALLINGER Azithromycin to Prevent BPD in American Heart Association (AHA) Uresplasma-Infected Preterms The Role of Mitochondrial Genetic $321,760 3/10/11-2/29/16 Background on Caloric Utilization and Biogenetics CASEY WEAVER $44,360 7/01/11-6/30/13 HHMI Howard Hughes Medical Institute DOUGLAS HURST Fellow Award American Cancer Society $39,000 6/01/11-5/31/12 Composition of SIN3 Protein Com- plexes in Breast Cancer Metastasis CASEY WEAVER $649,000 7/01/11-6/30/15 Crohn’s and Colitis Foundation of America (CCFA) YI-PING LI A Critical Role for T Cell-Derived IL NIH -6 in the Pathogenesis of Colitis Role of RGS10 (Regulator of $386,100 7/01/11-6/30/14 GProtein Signaling 10) in Osteo- clast Differentiation $210,778 10/01/10-03/31/11