Catalog Update01 - International_Update 31/01/2013 08:18 Page 1

Catalog update

High purity biochemical tools for life scientists

•Receptor agonists and antagonists •Ion channel modulators •Enzyme modulators •Signaling tools

March 2013

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Contents

Receptors & Transporters Page Receptors & Transporters (continued) Page Adenosine & Purinergics Peptide Receptors 17 P1 5 Prostanoid 18 P2 5 Serotonin

Adrenoceptors 5 5-HT1 18

Cannabinoid 6 5-HT2 19

Catalytic Receptors 7 5-HT3 19

Chemokine 7 5-HT4 19

Dopamine 7 5-HT5 19

Enzyme-Linked Receptors 9 5-HT6 20

G protein-coupled estrogen 10 5-HT7 20 GABA Non-selective 20

GABAA 10 Transporters 20

GABAB 10 Sigma 20 Non-selective 10 Smoothened 20

Other 11 Sphingosine 1-Phosphate Receptors 21 Transporters 11 TGR5 21 Glutamate Toll-Like Receptors 21 AMPA & Kainate 11 Transporters 21 Broad spectrum / non-selective 11

mGlu: General 12 Ion Channels Page mGlu: Group I 12 Calcium 22 mGlu: Group I & II 12 Chloride 22 mGlu: Group II 12 Cyclic nucleotide-gated 22 mGlu: Group III 13 Ionophores, indicators & chelators 22 NMDA: AP-2 binding site 13 Other 22 NMDA: Glutamate Site 13 Potassium 22 NMDA: Glycine Site 13 Sodium 23 NMDA: Ion Channel Site 13 TRP 23 NMDA: Polyamine Site 14

Transporters 14 Enzymes Page Glycine 14 ATPase & GTPase 23 Histamine 14 Caspase 24 Imidazoline 15 Cholinesterase 24 Melatonin 15 Coenzymes 24 Muscarinic 15 Cyclase 24 Nicotinic 15 Cyclooxygenase 24 Nuclear Receptors 16 Cytochrome P450 25 Opioids 16 Deacetylase 25

Orphan 7-TM Receptors 17 Dehydrogenase 25

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Contents

Enzymes (continued) Page Signaling (continued) Page Demethylase 25 Ca2+ Signaling 34 Hydrolase 25 Cytoskeleton & motor proteins 34 Isomerase 26 DNA, RNA & protein synthesis 34 Kinase 26 Endocytosis & exocytosis 35 Oxidases 29 Epigenetics 36 Oxygenase 29 Extracellular matrix & cell adhesion 36 Phosphatase 29 Heat shock proteins 36 Phosphodiesterase 29 Immunomodulators 37 Phospholipase & Lipase 29 Lipid signaling 37 Polymerase 29 Stem Cells 38 Protease 30 Reductase 30 Signal transduction Page Secretase 30 Cytokines, NF-κB & IκB 39 Synthetase & synthase 30 G-Protein related 39

Telomerase 30 Hedgehog signaling 39 Transaminase 30 Inositol & cAMP signaling 39 Transferase 31 JAK/STAT 39 MAPK 40 Signaling Page Nitric oxide & oxidative stress 40 Amyloidogenesis 31 PI3K/Akt 41 Angiogenesis 31 Wnt signaling 41 Apoptosis & cell cycle 32

Symbol key

Ç Products added since publication of 2012 catalog. É Just-Add-Water: typically water-soluble to at least 10 mM or above. Ë Country restrictions and/or license requirements may apply. Please contact customer services for further details. fi Not currently for sale in the US fi Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Iminodyn-22™, Iminodyn-17™, Dynole-34-2™, Dynole-31-2™, RTIL-13™, MiTMAB™, OcTMAB™, Pitstop 1™, Pitstop 2™, Dyngo-4a™, Rhodadyn B10™, Rhodadyn C10™, are trademarks of Children's Medical Research Institute and Newcastle Innovation Ltd. fi Sold under exclusive license from Columbia University; Patent Pending fi Sold under license from Columbia University; Patent Pending fi Sold under license from Eli Lilly and company fi Sold under license from Hugin Neurochemicals fi Sold under license from Virginia Commonwealth University. fi Sold under license granted by the University of Pennsylvania. fi Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Pitstop-1™ and Pitstop-2™ is a trademark of Freie Universität Berlin, Newcastle Innovation Ltd. and Children's Medical Research Institute

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Great supporting data for your research

Tried and tested Apoptotic stimuli biological information Every product has a detailed description including Bcl-2 Family members potency (Ki, IC50 etc.), cell permeability and solubility data.

Mitochondria

Apoptosome Useful references for HtrA2 SMAC cyt-c formation IAP ARTS every product antagonists Every Abcam Biochemicals product is listed with a range of useful references and citations to help you Inhibitors of XIAP Apaf-1 figure out the best conditions for your experiment - apoptosis from in vitro to in vivo; western blotting to (IAPs) immunofluorescence. Caspase 9

Initiator caspase

Caspase 7 Effector Caspase 3 Find the product caspases you need • You can check chemical names, structures, formula and CAS number online. Apoptosis

• Our smiles information now allows you to recreate structures using chemical drawing packages.

Guides to signalling Examples include: pathways and pharmacology • Akt signaling • MAPK signaling • Apoptosis • Glutamate

Visit: www.abcam.com/at-a-glance for the full range of @ a glance guides

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Receptors & Transporters: Adenosine & Purinergics: P1

Cat No. Product Pack Sizes Purity Description ab120498 Adenosine É 1g 5g 25g >99% Endogenous P1 receptor agonist ab120240 Caffeine É 1g 5g >99% PDE inhibitor. Adenosine antagonist Ç ab120453 CGS 21680 10mg 50mg >98% Potent, selective A2A agonist 6 ab120434 2-Chloro-N -cyclopentyladenosine (CCPA) 10mg 50mg >98% Highly potent, selective A1 agonist ab120037 2-Chloroadenosine (CADO) É 10mg 50mg 250mg >98% Adenosine agonist

ab120442 8-(3-Chlorostyryl)caffeine 10mg 50mg >98% Selective A2A receptor antagonist. MAO-B inhibitor. 6 ab120472 N -Cyclohexyladenosine 50mg 250mg >98% Selective A1 receptor agonist 6 ab120398 N -Cyclopentyladenosine (CPA) 25mg 100mg >99% Potent, selective A1 agonist

ab120396 DPCPX 25mg 100mg >99% Potent A1 antagonist

ab120458 HENECA 1mg 10mg >99% Selective A2A receptor agonist

ab120438 IB-MECA 5mg 25mg >97% Highly potent and selective A3 agonist ab120724 Inosine Ç É 100mg 1g >99% Purine nucleoside. Adenosine metabolite. ab120452 Iodotubercidin 1mg 5mg >95% Potent, adenosine kinase inhibitor fi ab120397 MRS 1754 10mg 50mg >98% Selective A2B antagonist ab120440 NECA 10mg 50mg >99% Highly potent adenosine agonist ab118162 NECA fluorescent ligand (Red) Ç 50μg 100μg >97% Fluorescent non-selective adenosine agonist Ç ab120921 Reversine 1mg 5mg >98% Potent selective A3 receptor antagonist

ab120439 SCH-58261 10mg 50mg >99% Potent, highly selective A2A antagonist ab118163 XAC Fluorescent ligand-1 (Red) Ç 50μg 100μg >97% Fluorescent non-selective adenosine antagonist Ç ab118164 XAC A3 fluorescent ligand (Red) 50μg 100μg >97% Fluorescent A3 antagonist

ab120218 ZM 241385 10mg 50mg >99% Potent, selective A2A antagonist

Receptors & Transporters: Adenosine & Purinergics: P2

Cat No. Product Pack Sizes Purity Description

ab120413 A 438079 10mg 50mg >98% Potent, competitive P2X7 receptor antagonist ab120385 ATP disodium salt É 1g 5g 10g 25g >99% P2 receptor agonist. Signalling molecule. É ab120389 Brilliant Blue G 100mg 1g >90% Potent, noncompetitive P2X7 antagonist Ç É ab120444 BzATP triethylammonium salt 1mg 5mg 25mg >99% Potent, prototypic P2X7 agonist. P2 agonist.

ab120387 (±)-Clopidogrel 10mg 50mg >99% Potent, selective P2Y12 antagonist É ab120395 GW791343 10mg 50mg >99% P2X7 allosteric modulator

ab120421 KN-62 1mg 5mg >98% CaM kinase II inhibitor. P2X7 antagonist. É ab120414 MRS 2179 10mg 50mg >98% Potent, selective P2Y1 antagonist Ç É ab120445 MRS 2211 10mg 50mg >95% Selective competitive P2Y13 antagonist É ab120454 NF023 10mg 50mg >97% Competitive P2X1 receptor antagonist Ç É ab120415 NF 449 10mg 50mg >95% Highly selective, potent P2X1 receptor antagonist É ab120403 β-Nicotinamide adenine dinucleotide (β-NAD) 25mg 250mg 1g >96% Coenzyme and enzyme substrate. P2Y11 agonist. ab120009 PPADS É 10mg 50mg 250mg P2 purinergic receptor antagonist. ab120422 Suramin hexasodium salt Ç É 100mg 500mg >99% Non-selective P2 purinergic antagonist É ab120384 UDP-glucose 100mg 1g >98% Highly potent P2Y14 agonist É ab120383 UDP sodium salt (Uridine 5’-diphosphate) 100mg 500mg >98% P2Y6 agonist. P2Y14 ligand.

Receptors & Transporters: Adrenoceptors

Cat No. Product Pack Sizes Purity Description Ç ab118167 Alprenolol fluorescent ligand (Red) 50μg 100μg >97% Fluorescent β2 adrenoceptor antagonist ab120576 Asenapine maleate Ç 10mg 50mg >99% Multiple receptor antagonist. Anti-psychotic agent. Ç É ab120752 (R,S)-Atenolol 1g >99% β1 adrenoceptor antagonist Ç ab120856 (S)-(-)-Atenolol 10mg 50mg >98% Selective β1 adrenoceptor antagonist Ç ab120785 Atipamezole hydrochloride 10mg 50mg >99% Selective α2 adrenergic receptor antagonist Ç ab120783 (±)-Bisoprolol hemifumarate 10mg 50mg >99% Selective β1 antagonist Ç É ab120520 BMY 7378 dihydrochloride 10mg 50mg >99% 5-HT1A partial agonist. α-adrenoceptor antagonist. Ç ab120806 BRL 44408 maleate 10mg 50mg >99% Selective α2A adrenoceptor antagonist ab141132 Bupranolol Ç 100mg >99% Potent non-selective β adrenoceptor antagonist ab120534 Bupropion hydrochloride Ç É 50mg 250mg 1g >98% Non-selective DAT/NET inhibitor Ç ab118171 (S)-Carazolol fluorescent ligand (Red) 50μg 100μg >97% Fluorescent β2 antagonist/partial β3 agonist Ç ab120709 Carvedilol 50mg 250mg >99% Potent β and α1-adrenoceptor antagonist Ç É ab120729 (±)-Chlorpheniramine maleate 100mg >99% Potent H1 antagonist and SNRI ab120730 Chlorpromazine hydrochloride Ç É 1g 5g >99% Typical antipsychotic. Non-selective receptor antagonist. ab120954 Cimaterol Ç 10mg 50mg >99% β-adrenoceptor agonist Ç É ab120753 Clonidine hydrochloride 100mg >99% α2 adrenoceptor agonist Ç É ab120767 Dexmedetomidine hydrochloride 10mg 50mg >99% Potent, highly selective α2 agonist Ç ab120768 Dobutamine hydrochloride 50mg >99% β1 and β2 adrenoceptor agonist Ç ab120754 Doxazosin mesylate 50mg >99% Selective α1-adrenoceptor antagonist

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Receptors & Transporters: Adrenoceptors

Cat No. Product Pack Sizes Purity Description Ç ab120786 Formoterol hemifumarate 10mg 50mg >99% Potent long-acting β2-adrenergic receptor agonist Ç ab141131 HEAT hydrochloride (BE2254) 10mg 50mg >99% Highly selective α1 adrenoceptor antagonist Ç ab120808 ICI 118551 hydrochloride 10mg 50mg >99% Highly selective β2 adrenergic receptor antagonist Ç ab141130 Idazoxan hydrochloride 10mg 50mg >99% α2-adrenoceptor antagonist and I2 ligand ab141046 Imipramine hydrochloride Ç 5g >98% Tricyclic antidepressant ab120710 Isoprenaline hydrochloride Ç É 100mg >99% Non selective β-adrenoceptor agonist Ç ab141129 JP1302 dihydrochloride 10mg 50mg >99% Potent and selective α2C antagonist ab120769 Maprotiline hydrochloride Ç É 100mg >99% Noradrenaline reuptake inhibitor Ç É ab120787 Medetomidine hydrochloride 10mg 50mg >99% Selective α2 adrenoceptor agonist Ç É ab120711 Metoprolol tartrate 50mg >99% β1-adrenergic receptor antagonist Ç ab120788 Mianserin hydrochloride 50mg >99% Multiple receptor antagonist. Activity at 5-HT2,

H1 and α2 receptors. ab120755 Milnacipran hydrochloride Ç É 10mg 50mg >99% Serotonin and norepinephrine reuptake inhibitor

ab120068 Mirtazapine 10mg 50mg >99% Antidepressant. α2, 5HT2, 5HT3 antagonist Ç ab120789 Moxonidine hydrochloride 10mg 50mg >99% I1 imidazoline receptor and α2 adrenergic agonist Ç ab120756 Naftopidil hydrochloride 10mg 50mg >98% α1 adrenergic receptor antagonist Ç ab120543 NAN-190 hydrobromide 50mg 250mg >99% Potent 5-HT1A antagonist Ç ab120790 Nebivolol hydrochloride 10mg 50mg >99% Selective β1 antagonist Ç ab120587 Nefazodone hydrochloride 10mg 50mg >99% Potent 5-HT2A antagonist ab141134 Nisoxetine hydrochloride Ç 10mg 50mg >99% Potent and selective norepinephrine reuptake (NET) inhibitor ab120717 L-(-)-Norepinephrine-(+)-bitartrate (Noradrenaline) Ç É 1g 5g >99% Endogenous α adrenoceptor agonist Ç É ab120770 Octopamine hydrochloride 100mg >99% Full β3 agonist: invertebrate biogenic amine ab120736 Olanzapine Ç 10mg 50mg >99% Non-selective 5-HT, dopamine, histamine and muscarinic antagonist. Ç É ab120712 Oxymetazoline hydrochloride 100mg >99% α1A and partial α2A adrenoceptor agonist. Ç É ab120761 (R)-(-)-Phenylephrine hydrochloride 100mg >99% α1 adrenoceptor agonist

ab120521 Pindolol 250mg 1g >99% 5-HT1A and 5-HT1B receptor antagonist Ç ab118170 Pindolol Fluorescent ligand (Red) 50μg 100μg >97% Fluorescent β2 antagonist ab120238 Prazosin hydrochloride 50mg 250mg >99% α-adrenoceptor antagonist. Melatonin antagonist. Ç ab140138 (S)-Propranolol Fluorescent Ligand (green) 50μg 100μg >95% Fluorescent ß2 adrenoceptor antagonist Ç ab118168 Propranolol Fluorescent ligand (Red) 50μg 100μg >97% Fluorescent β2 adrenoceptor antagonist Ç ab118169 (S)-Propranolol fluorescent ligand (Red) 50μg 100μg >97% Fluorescent β2 adrenoceptor antagonist ab120757 Propranolol hydrochloride Ç É 100mg >99% Potent β-adrenoceptor antagonist ab141133 (S)-Propranolol hydrochloride Ç 100mg >98% Non-selective β-adrenoceptor antagonist Ç ab120875 Rauwolscine hydrochloride 100mg >99% Potent α2 adrenergic antagonist ab120157 Reboxetine mesylate É 10mg 50mg >99% Noradrenaline reuptake inhibitor ab120601 Rotigotine hydrochloride Ç É 10mg 50mg >99% Dopamine receptor agonist Ç ab118165 Salbutamol fluorescent ligand (Red) 50μg 100μg >97% Fluorescent β2 adrenoceptor agonist ab120714 Salbutamol hemisulfate Ç É 50mg 250mg >99% Non-selective β-adrenoceptor agonist ab120529 Sibutramine hydrochloride Ë 10mg 50mg >98% Serotonin, noradrenaline & dopamine re-uptake inhibitor Ç ab141135 SR 59230A hydrochloride 10mg 50mg >99% Potent, selective β3-adrenoceptor antagonist Ç É ab120772 Tamsulosin hydrochloride 10mg 50mg >99% Potent, selective α1A antagonist Ç ab120792 Terbutaline hemisulfate 1g 5g >99% Selective β2 receptor agonist ab120784 (S)-Timolol maleate Ç 100mg >99% Potent non-selective β-adrenoceptor antagonist ab120758 (R)-Tomoxetine hydrochloride Ç É 10mg 50mg >99% Potent, selective norepinephrine reuptake inhibitor Ç ab120773 UK 14,304 tartrate 10mg 50mg >99% Selective α2 adrenergic agonist ab120715 Venlafaxine hydrochloride Ç É 10mg 50mg >99% Serotonin-norepinephrine reuptake inhibitor Ç É ab120759 Xylazine hydrochloride 1g >99% α2 adrenergic receptor agonist É ab120239 Yohimbine hydrochloride 1g 5g >99% Selective α2-adrenoceptor antagonist

Receptors & Transporters: Cannabinoid

Cat No. Product Pack Sizes Purity Description

ab120251 ACEA (Arachidonyl-2-chloroethylamide) 5mg 25mg >98% Potent, selective CB1 agonist

ab120096 ACEA (ethanol solution) 5mg 25mg 100mg >98% Potent, selective CB1 agonist

ab120097 ACPA (Arachidonylcyclopropylamide) 10mg 50mg >98% CB1 agonist Ç ab120934 AM1241 5mg 25mg >97% Potent, selective CB2 agonist

ab120088 AM251 1mg 10mg 50mg >99% CB1 receptor antagonist / inverse agonist ab120095 AM404 10mg 50mg >99% Anandamide transport inhibitor

ab120404 AM630 (Iodopravadoline) 10mg 50mg >98% CB2 antagonist / inverse agonist ab120087 Anandamide (ethanol solution) 5mg 25mg >98% Endogenous cannabinoid ab120429 Anandamide (in water soluble emulsion) É 10mg 50mg >98% Endogenous cannabinoid in water soluble emulsion

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Receptors & Transporters: Cannabinoid

Cat No. Product Pack Sizes Purity Description ab120446 Anandamide-d4 (ethanol solution) 1mg 5mg >98% Internal standard for anandamide quantification Ç Ë ab120919 2-Arachidonoyl glycerol-d8 25μg 100μg >99% Potent, endogenous CB1 agonist ab120098 2-Arachidonylglycerol (acetonitrile solution) Ë 5mg 25mg >95% Endogenous cannabinoid agonist ab120346 N-Arachidonylglycine (NAGly) 5mg 25mg 100mg >98% T-type Ca2+ channel blocker. Endogenous GLYT2 inhibitor. Ç ab120917 Arvanil 10mg 50mg >98% Potent CB1 and TRPV1 agonist ab120448 (-)-Cannabidiol Ë 10mg 50mg >98% Common constituent of Cannabis

ab120344 Gp 1a 10mg 50mg >99% Highly potent and selective CB2 agonist Ç Ë ab120918 HU-210 5mg 25mg >98% Highly potent CB1 agonist ab120922 HU-331 Ç 5mg 25mg >95% Potent cannabinoid quinone. Topoisomerase II inhibitor. Ç Ë ab120887 JWH 200 5mg 25mg >98% Potent CB1 agonist ab120900 JWH 250 Ç Ë 5mg 25mg >98% Non-selective CB agonist Ç Ë ab120932 L-759,633 5mg 10mg >98% Potent, selective CB2 agonist

ab120361 (R)-(+)-Methanandamide (ethanol solution) 5mg 25mg >98% Stable anandamide analogue. CB1 receptor agonist.

ab120099 NADA (N-Arachidonyldopamine) 5mg 25mg >98% Endogenous CB1 / TRPV1 agonist ab120407 O-1602 fi 10mg 50mg >98% Potent, selective GPR55 agonist fi ab120405 O-1918 10mg 50mg >97% Antagonist of the non-CB1 vascular cannabinoid receptor ab120877 OMDM-2 Ç 5mg 50mg >98% Potent, selective anandamide reuptake inhibitor

ab120342 Org 27569 10mg 50mg >99% Potent CB1 receptor allosteric modulator ab120345 Palmitoylethanolamide 10mg 50mg >99% Potent, selective GPR55 agonist ab120668 URB 597 Ç 5mg 25mg >98% Potent and selective FAAH inhibitor ab120431 Water soluble emulsion (blank) É 1ml 10ml Water soluble emulsion. Negative control.

Receptors & Transporters: Catalytic Receptors

Cat No. Product Pack Sizes Purity Description ab120301 Amyloid β Peptide (1-42) (human) 100μg 1mg >95% Predominant amyloid-β protein fragment

Receptors & Transporters: Chemokine

Cat No. Product Pack Sizes Purity Description ab120718 AMD3100 octahydrochloride Ç É 10mg >99% Highly selective CXCR4 antagonist ab120810 DAPTA Ç 1mg >98% Potent, selective CCR5 antagonist ab141148 [D-Lys3]-GHRP-6 (DLS) Ç 5mg >99% Ghrelin receptor (GHS-R1a) and CCR5 antagonist ab120813 RS 504393 Ç 10mg >99% Highly selective CCR2 chemokine receptor antagonist ab120895 SB 225002 Ç 10mg 50mg >95% A selective non-peptide CXCR2 antagonist ab120821 SB 297006 Ç 10mg 50mg >99% Potent, selective CCR3 antagonist ab120648 SB 328437 Ç 10mg 50mg >99% Highly potent and selective CCR3 antagonist ab120823 Teijin compound 1 hydrochloride Ç 10mg 50mg >99% Potent, selective CCR2 antagonist ab120643 Tranilast Ç 10mg 50mg >99% Anti-inflammatory agent ab120814 ZK 756326 Ç 10mg 50mg >99% Non-peptide CCR8 chemokine receptor agonist

Receptors & Transporters: Dopamine: D1

Cat No. Product Pack Sizes Purity Description ab120150 6,7-ADTN hydrobromide É 10mg 50mg >99% Dopamine agonist ab120565 Dopamine hydrochloride Ç 1g 5g >99% Endogenous neurotransmitter ab120736 Olanzapine Ç 10mg 50mg >99% Non-selective 5-HT, dopamine, histamine and muscarinic antagonist. ab120601 Rotigotine hydrochloride Ç É 10mg 50mg >99% Dopamine receptor agonist Ç ab120597 SCH 23390 hydrochloride 10mg 50mg >99% Selective D1-like dopamine receptor antagonist Ç ab120619 (R)-(+)-SKF38393 hydrochloride 5mg >99% Selective D1 partial agonist. Active enantiomer of (±)-SKF-38393. Ç É ab120740 (±)-SKF38393 hydrochloride 100mg >99% D1-like dopamine receptor agonist Ç ab118172 SKF83566 Fluorescent ligand (Red) 50μg 100μg >97% Fluorescent D1 antagonist Ç ab140139 SKF83566 Fluorescent Ligand (green) 50μg 100μg >95% Fluorescent D1 antagonist

Receptors & Transporters: Dopamine: D2

Cat No. Product Pack Sizes Purity Description Ç ab120764 Aripiprazole 100mg 500mg >99% Partial dopamine D2 agonist Ç ab120574 Bromocriptine mesylate 100mg 500mg >99% Potent, selective D2-like dopamine receptor agonist Ç ab120564 Cabergoline 10mg 50mg >99% D2-like receptor agonist ab120730 Chlorpromazine hydrochloride Ç É 1g 5g >99% Typical antipsychotic. Non-selective receptor antagonist.

ab120026 N-Desmethyl clozapine (Normethylclozapine) 10mg 50mg >99% Clozapine metabolite. M1 agonist. D2/D3 agonist.

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Receptors & Transporters: Dopamine: D2

Cat No. Product Pack Sizes Purity Description Ç ab120566 Domperidone 50mg 500mg >99% Peripheral D2-like receptor antagonist ab120565 Dopamine hydrochloride Ç 1g 5g >99% Endogenous neurotransmitter Ç ab120602 Eticlopride hydrochloride 10mg 50mg >99% Selective D2-like receptor antagonist

ab120080 Haloperidol 100mg >99% D2 antagonist Ç ab120596 L-741,626 10mg 50mg >99% Potent and selective D2 antagonist ab120736 Olanzapine Ç 10mg 50mg >99% Non-selective 5-HT, dopamine, histamine and muscarinic antagonist. Ç ab120569 Pramipexole dihydrochloride 10mg 50mg >99% Dopamine D2-like receptor agonist. D3-preferring. Ç ab120737 Quetiapine hemifumarate 10mg 50mg >99% D2 and 5-HT2 antagonist. Antipsychotic. Ç ab120563 (S)-(-)-Raclopride 10mg 50mg >99% D2 receptor antagonist

ab120393 Risperidone 10mg 50mg >99% Atypical antipsychotic. 5HT2A / D2 antagonist. Ç É ab120575 Ropinirole hydrochloride 10mg 50mg >99% Selective D2-like receptor agonist ab120601 Rotigotine hydrochloride Ç É 10mg 50mg >99% Dopamine receptor agonist É ab120549 Spiperone hydrochloride 50mg 250mg >99% 5-HT and D2-like receptor antagonist Ç ab120578 (R,S)-Sulpiride 100mg >99% D2-like dopamine receptor antagonist Ç ab120579 (S)-Sulpiride 100mg 1g >99% D2-like dopamine antagonist. Active enantiomer.

ab120394 Ziprasidone (CP 88059) 10mg 50mg >99% Atypical antipsychotic. 5HT2A / D2 antagonist.

Receptors & Transporters: Dopamine: D3

Cat No. Product Pack Sizes Purity Description Ç ab120574 Bromocriptine mesylate 100mg 500mg >99% Potent, selective D2-like dopamine receptor agonist Ç ab120564 Cabergoline 10mg 50mg >99% D2-like receptor agonist ab120730 Chlorpromazine hydrochloride Ç É 1g 5g >99% Typical antipsychotic. Non-selective receptor antagonist.

ab120026 N-Desmethyl clozapine (Normethylclozapine) 10mg 50mg >99% Clozapine metabolite. M1 agonist. D2/D3 agonist. Ç ab120566 Domperidone 50mg 500mg >99% Peripheral D2-like receptor antagonist ab120565 Dopamine hydrochloride Ç 1g 5g >99% Endogenous neurotransmitter Ç ab120602 Eticlopride hydrochloride 10mg 50mg >99% Selective D2-like receptor antagonist Ç ab120742 Nafadotride 10mg 50mg >99% Potent, selective D3 antagonist Ç ab120569 Pramipexole dihydrochloride 10mg 50mg >99% Dopamine D2-like receptor agonist. D3-preferring. Ç É ab120575 Ropinirole hydrochloride 10mg 50mg >99% Selective D2-like receptor agonist ab120601 Rotigotine hydrochloride Ç É 10mg 50mg >99% Dopamine receptor agonist Ç ab120567 SB-277011-A dihydrochloride 5mg 25mg >98% Potent, highly selective D3 antagonist É ab120549 Spiperone hydrochloride 50mg 250mg >99% 5-HT and D2-like receptor antagonist Ç ab120578 (R,S)-Sulpiride 100mg >99% D2-like dopamine receptor antagonist Ç ab120579 (S)-Sulpiride 100mg 1g >99% D2-like dopamine antagonist. Active enantiomer. Ç É ab120570 U 99194 maleate (PNU 99194) 10mg 50mg >99% Potent, selective D3 antagonist

Receptors & Transporters: Dopamine: D4

Cat No. Product Pack Sizes Purity Description Ç ab120581 A-412997 dihydrochloride 10mg 50mg >98% Highly selective D4 agonist Ç ab120574 Bromocriptine mesylate 100mg 500mg >99% Potent, selective D2-like dopamine receptor agonist Ç ab120564 Cabergoline 10mg 50mg >99% D2-like receptor agonist ab120730 Chlorpromazine hydrochloride Ç É 1g 5g >99% Typical antipsychotic. Non-selective receptor antagonist. Ç ab120566 Domperidone 50mg 500mg >99% Peripheral D2-like receptor antagonist ab120565 Dopamine hydrochloride Ç 1g 5g >99% Endogenous neurotransmitter Ç É ab120598 L-745870 trihydrochloride 10mg 50mg >99% Highly potent, selective brain penetrant D4 antagonist ab120736 Olanzapine Ç 10mg 50mg >99% Non-selective 5-HT, dopamine, histamine and muscarinic antagonist. Ç ab120568 PD 168077 maleate 10mg 50mg >99% Potent, selective D4 agonist Ç ab120611 PD 168568 dihydrochloride 10mg 50mg >99% Potent and selective D4 antagonist Ç ab120569 Pramipexole dihydrochloride 10mg 50mg >99% Dopamine D2-like receptor agonist. D3-preferring. É ab120549 Spiperone hydrochloride 50mg 250mg >99% 5-HT and D2-like receptor antagonist Ç ab120578 (R,S)-Sulpiride 100mg >99% D2-like dopamine receptor antagonist Ç ab120579 (S)-Sulpiride 100mg 1g >99% D2-like dopamine antagonist. Active enantiomer.

Receptors & Transporters: Dopamine: D5

Cat No. Product Pack Sizes Purity Description ab120565 Dopamine hydrochloride Ç 1g 5g >99% Endogenous neurotransmitter Ç ab120597 SCH 23390 hydrochloride 10mg 50mg >99% Selective D1-like dopamine receptor antagonist Ç É ab120740 (±)-SKF38393 hydrochloride 100mg >99% D1-like dopamine receptor agonist

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Receptors & Transporters: Dopamine: Non-selective

Cat No. Product Pack Sizes Purity Description ab120576 Asenapine maleate Ç 10mg 50mg >99% Multiple receptor antagonist. Anti-psychotic agent. Ç ab120627 BRL 54443 10mg 50mg >99% Selective agonist at 5-HT1E and 5-HT1F receptors Ç ab120564 Cabergoline 10mg 50mg >99% D2-like receptor agonist ab120019 Clozapine 50mg 500mg >99% Atypical antipsychotic Ç É ab120732 Cyproheptadine hydrochloride 50mg 100mg >99% Potent H1 and 5-HT2B antagonist. Non-selective receptor antagonist. Ç ab120566 Domperidone 50mg 500mg >99% Peripheral D2-like receptor antagonist ab120565 Dopamine hydrochloride Ç 1g 5g >99% Endogenous neurotransmitter ab120613 Flupenthixol dihydrochloride Ç 50mg >99% Non-selective dopamine receptor antagonist Ç ab120569 Pramipexole dihydrochloride 10mg 50mg >99% Dopamine D2-like receptor agonist. D3-preferring. ab120601 Rotigotine hydrochloride Ç É 10mg 50mg >99% Dopamine receptor agonist ab120580 Thioridazine hydrochloride Ç É 100mg 500mg >99% Dopamine receptor antagonist ab120739 Trifluoperazine dihydrochloride Ç 1g >99% Cell permeable calmodulin antagonist

Receptors & Transporters: Dopamine: Other

Cat No. Product Pack Sizes Purity Description ab120604 (R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride) Ç É 250mg 1g >99% MAO-B selective inhibitor ab120573 L-DOPA Ç 5g 25g 100g >99% Dopamine (ab120565) precursor ab120603 Salsolinol hydrochloride Ç É 100mg >99% Endogenously synthesised dopamine derivative

Receptors & Transporters: Dopamine: Transporters

Cat No. Product Pack Sizes Purity Description ab120534 Bupropion hydrochloride Ç É 50mg 250mg 1g >98% Non-selective DAT/NET inhibitor ab120866 FFN102 (Mini 102) Ç fi 5mg >98% Exogenous fluorescent substrate ab120867 FFN202 (Mini 202) Ç fi 5mg >97% Novel, pH responsive FFN. Enables pH measurement of synaptic or secretory vesicles. ab120331 FFN511 fi 1mg 5mg >99% Fluorescent false neurotransmitter; highly efficient optical tracer of dopamine ab120607 GBR 12909 dihydrochloride Ç É 10mg 50mg >99% Selective dopamine transport inhibitor ab120609 Reserpine Ç 250mg 1g >98% Irreversible vesicular monoamine transporter (VMAT2) antagonist ab120529 Sibutramine hydrochloride Ë 10mg 50mg >98% Serotonin, noradrenaline & dopamine re-uptake inhibitor ab120758 (R)-Tomoxetine hydrochloride Ç É 10mg 50mg >99% Potent, selective norepinephrine reuptake inhibitor

Receptors & Transporters: Enzyme-Linked Receptors

Cat No. Product Pack Sizes Purity Description ab120860 (+)-Abscisic acid Ç 1mg >99% Phytohormone; produced by a variety of cells in humans and animals ab120901 ABT-869 (Linifanib) Ç 5mg 10mg >98% Potent VEGF and PDGF receptor tyrosine kinase inhibitor ab141170 AG 1296 Ç fi 5mg 25mg >99% Potent specific PDGF receptor tyrosine kinase inhibitor ab141059 AG-879 Ç 10mg >99% Selective TrkA receptor inhibitor ab120718 AMD3100 octahydrochloride Ç É 10mg >99% Highly selective CXCR4 antagonist ab141338 AMG-25 Ç 1mg 5mg >95% Potent c-Kit inhibitor ab141339 AMG-Tie2-1 Ç 1mg 5mg >95% Highly potent, non-selective TIE2 (TEK) inhibitor ab120636 Andrographolide Ç 100mg >99% Potent anti-inflammatory agent ab120811 BX 513 hydrochloride Ç 10mg 50mg >99% Potent and selective CCR1 antagonist ab141402 Canertinib (CI-1033) Ç 5mg 50mg >99% Potent irreversible EGFR and HER2/ErbB2 tyrosine kinase inhibitor ab120655 Celastrol from Celastrus scandens Ç 10mg 50mg >99% Anti-inflammatory and anti-proliferative agent ab141349 CP-724714 Ç 10mg 50mg >95% Potent, selective HER2/ErbB2 tyrosine kinase inhibitor ab120666 Cryptotanshinone Ç 10mg 50mg >99% STAT3 inhibitor with diverse biological activities ab141351 CYC-116 Ç 10mg 50mg >95% Potent Aurora kinase A/B and VEGFR inhibitor ab120996 7,8-Dihydroxyflavone (7,8-DHF) Ç 10mg 50mg >99% Selective TrkB receptor agonist. Flavonoid. ab120843 Dorsomorphin Ç 10mg 50mg >99% Potent, selective and reversible AMP-kinase inhibitor. Selective for BMP signaling. ab120881 Erlotinib (CP-358,774) Ç 250mg 1g >98% Potent, selective and reversible EGFR tyrosine kinase inhibitor ab120112 Genistein 10mg 50mg 100mg >99% Protein tyrosine kinase inhibitor. Anticancer agent.

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Receptors & Transporters: Enzyme-Linked Receptors

Cat No. Product Pack Sizes Purity Description ab141092 Gly-Arg-Gly-Asp-Ser Ç 1mg 5mg >98% Synthetic integrin antagonist ab141357 Ki20227 Ç 10mg 50mg >95% Highly selective c-Fms tyrosine kinase inhibitor ab120662 Luteolin Ç 10mg 50mg >99% Antioxidant, anti-inflammatory, anti-cancer flavonoid ab141117 PD 173074 Ç 10mg 50mg >99% Potent FGFR1 and FGFR3 inhibitor ab141171 Pelitinib (EKB-569) Ç 5mg 25mg >98% Irreversible EGFR inhibitor ab120725 Pentoxifylline Ç É 1g 5g >99% Phosphodiesterase inhibitor. Cytokine inhibitor. ab141364 R428 Ç 1mg 5mg >95% Selective Axl kinase inhibitor ab120163 SB431542 1mg 5mg 10mg >99% ALK inhibitor ab141368 SU-5402 Ç 1mg 5mg >95% Potent FGFR and VEGFR inhibitor ab141374 TG101209 Ç 10mg 50mg >95% Potent, selective JAK2 inhibitor. Flt3 and RET inhibitor. ab120643 Tranilast Ç 10mg 50mg >99% Anti-inflammatory agent ab141369 Vargatef Ç 10mg 50mg >95% Potent VEGFR, PDGFR and FGFR inhibitor

Receptors & Transporters: G protein-coupled estrogen

Cat No. Product Pack Sizes Purity Description ab120657 17β-Estradiol Ç 100mg 1g >99% Selective agonist of ER receptor

Receptors & Transporters: GABA: GABAA

Cat No. Product Pack Sizes Purity Description

ab120107 (+)-Bicuculline 50mg >98% GABAA antagonist É ab120108 (-)-Bicuculline methiodide 10mg 50mg >98% GABAA antagonist É ab120109 (-)-Bicuculline methobromide 10mg 50mg >98% GABAA antagonist É ab120110 (-)-Bicuculline methochloride 10mg 50mg >98% GABAA antagonist

ab120311 Etomidate 10mg 50mg >98% GABAA agonist ab120242 Flumazenil 10mg 50mg >99% Benzodiazepine antagonist ab120314 Furosemide 1g 5g 10g >99% Inhibitor of the Na+/2Cl-/K+ cotransporter.

Also GABAA antagonist. ab120376 GABA and Glutamate Antagonists Kit É 1kit Kit of GABA and Glutamate antagonists É ab120094 Muscimol 1mg 5mg 10mg 50mg >99% Potent, selective GABAA agonist

ab120315 Picrotoxin 1g 5g GABAA antagonist ab120378 PK11195 10mg 50mg >98% Peripheral benzodiazepine receptor antagonist

ab120334 Propofol (ICI 35868) 1g >98% GABAA agonist É ab120042 SR95531 (Gabazine) 10mg 50mg >98% GABAA antagonist

ab120101 U 93631 10mg 50mg >99% GABAA antagonist ab120076 Zopiclone Ë fi 10mg 50mg >98% Benzodiazepine agonist

Receptors & Transporters: GABA: GABAB

Cat No. Product Pack Sizes Purity Description É ab120329 3-APPA (CGP 27492) 10mg 50mg >98% Potent, selective GABAB agonist É ab120325 (R)-Baclofen 10mg 50mg 250mg >98% Selective GABAB agonist. Active enantiomer.

ab120149 (R,S)-Baclofen 1g >99% GABAB agonist É ab120167 CGP 35348 10mg 50mg GABAB antagonist, brain penetrant É ab120330 CGP 52432 10mg 50mg >99% Potent GABAB antagonist Ç ab118173 CGP-54626A fluorescent ligand (Red) 50μg 100μg >97% Fluorescent GABAB antagonist Ç ab120337 CGP 55845 hydrochloride 10mg 50mg >98% Potent, selective GABAB antagonist

ab120492 CGP 7930 10mg 50mg >98% Positive GABAB receptor allosteric modulator ab120376 GABA and Glutamate Antagonists Kit É 1kit Kit of GABA and Glutamate antagonists

ab120318 rac BHFF 10mg 50mg >98% Potent, selective GABAB positive allosteric modulator É ab120327 Saclofen 10mg 50mg >99% GABAB antagonist É ab120250 SKF 97541 10mg 50mg >98% Highly potent GABAB agonist

Receptors & Transporters: GABA: Non-selective

Cat No. Product Pack Sizes Purity Description ab120359 GABA É 1g 5g Inhibitory neurotransmitter ab120376 GABA and Glutamate Antagonists Kit É 1kit Kit of GABA and Glutamate antagonists ab120409 RuBi-GABA É fi 10mg Novel caged-GABA compound, uncaged by visible light Ç ab141189 RuBi-GABA-PMe3 (water soluble) 10mg Novel modified version of RuBi-GABA. Inhibits neural activity.

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Receptors & Transporters: GABA: Other

Cat No. Product Pack Sizes Purity Description ab120310 Vigabatrin É 10mg 50mg >98% Irreversible inhibitor of GABA transaminase

Receptors & Transporters: GABA: Transporters

Cat No. Product Pack Sizes Purity Description ab120312 Nipecotic acid É 100mg 1g 5g >98% GABA reuptake inhibitor ab120317 NNC 05-2090 Ç 10mg 50mg >99% GABA uptake inhibitor ab120364 NNC 711 É 10mg 50mg >99% Potent, selective GAT-1 inhibitor ab120326 SKF89976A hydrochloride É 10mg 50mg >99% Highly selective GAT-1 inhibitor ab120237 Tiagabine hydrochloride É 10mg 50mg >99% Selective GAT-1 inhibitor

Receptors & Transporters: Glutamate: AMPA & Kainate

Cat No. Product Pack Sizes Purity Description ab120130 (R,S)-AMPA É 10mg 50mg >99% AMPA agonist ab120005 (S)-AMPA É 5mg 10mg 50mg >98% AMPA agonist ab120316 Aniracetam 50mg 250mg >99% AMPA receptor potentiator ab120062 (S)-5-Chlorowillardiine 10mg 50mg >98% AMPA / kainate agonist ab120017 CNQX 10mg 25mg 50mg >99% AMPA / kainate antagonist ab120044 CNQX disodium salt É 1mg 10mg 50mg >99% AMPA / kainate antagonist (water soluble) ab120061 Cyclothiazide 10mg 50mg >98% AMPA receptor desensitisation inhibitor ab120307 γ-DGG (γ-D-glutamylglycine) É 50mg >99% Ionotropic glutamate antagonist. Low affinity AMPA antagonist. ab120018 DNQX 10mg 50mg >99% AMPA / kainate antagonist ab120169 DNQX disodium salt É 10mg 50mg >99% AMPA / kainate antagonist (water soluble) ab120338 Domoic acid É 1mg 5mg >98% Kainate agonist. Neurotoxin. ab120036 (S)-5-Fluorowillardiine 10mg 50mg >99% Potent, selective AMPA agonist ab120399 (S)-5-Fluorowillardiine hydrochloride É >99% Potent, selective AMPA agonist. Only available in: Ionotropic agonists: Kit (ab120323). ab120336 GYKI 52466 É 10mg 50mg >99% Selective non-competitive AMPA antagonist ab120490 GYKI 53655 hydrochloride É 10mg 50mg >99% Non-competitive AMPA / kainate receptor antagonist ab120222 (S)-5-Iodowillardiine 10mg 50mg >98% GluK1 kainate agonist ab120401 (S)-5-Iodowillardiine hydrochloride >98% GluK1 kainate agonist. More water-soluble than (ab120222). Only available in: Ionotropic agonists: Kit (ab120323). ab120323 Ionotropic Agonists Kit 1kit Kit of agonists, antagonists and potentiators at AMPA, Kainate and NMDA receptors. ab120100 Kainic acid É 1mg 10mg 50mg >99% Prototypic kainate receptor agonist. ab120045 NBQX 10mg 50mg >98% AMPA / kainate antagonist ab120046 NBQX disodium salt É 1mg 10mg 50mg >98% AMPA / kainate antagonist; water soluble ab120063 (S)-5-Nitrowillardiine 10mg 50mg >98% AMPA / kainate agonist ab120433 Pep2m É 2mg >95% Inhibitor of AMPA receptor trafficking ab120257 Philanthotoxin-7,4 (PhTx-74) É 1mg 10mg 50mg >98% GluA1/GluA2 (formerly GluR1/2) inhibitor ab120010 Quisqualic acid É 5mg 10mg 50mg >99% Group I mGlu agonist. AMPA agonist. ab120194 UBP304 10mg >98% Potent, selective GluK1 (fomerly GLUK5) receptor antagonist ab120195 UBP308 10mg >98% Inactive isomer of the GluK1 (fomerly GLUK5) receptor antagonist UBP304 ab120168 UBP310 10mg 50mg >98% GluK1 and GluK3 selective antagonist ab120040 (S)-Willardiine 10mg 50mg >98% AMPA / kainate receptor agonist

Receptors & Transporters: Glutamate: Broad spectrum / non-selective

Cat No. Product Pack Sizes Purity Description ab120001 DL-AP4 100mg 1g >99% Broad spectrum glutamate antagonist ab120253 DL-AP4 sodium salt É 100mg 1g >99% Broad spectrum glutamate antagonist; water soluble ab120307 γ-DGG (γ-D-glutamylglycine) É 50mg >99% Ionotropic glutamate antagonist. Low affinity AMPA antagonist. ab120049 L-Glutamate É 1g 2.5g >99% Excitatory neurotransmitter ab120041 Ibotenic acid É 1mg 5mg 25mg >98% Excitotoxic agonist ab120064 Kynurenic acid 1g >99% Endogenous ionotropic / nicotinic antagonist ab120256 Kynurenic acid sodium salt É 1g 5g >99% Endogenous ionotropic / nicotinic antagonist; water soluble

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Receptors & Transporters: Glutamate: Broad spectrum / non-selective

Cat No. Product Pack Sizes Purity Description ab120038 2,3 cis-Piperidine dicarboxylic acid (cis PDA) É 50mg 250mg >98% Ionotropic receptor antagonist ab120408 RuBi-Glutamate É fi 10mg Novel caged-glutamate compound, uncaged by visible light

Receptors & Transporters: Glutamate: mGlu: General

Cat No. Product Pack Sizes Purity Description ab120321 mGlu Agonists Kit É 1kit Kit of mGlu agonists ab120322 mGlu Antagonists Kit 1kit Kit of mGlu antagonists

Receptors & Transporters: Glutamate: mGlu: Group I

Cat No. Product Pack Sizes Purity Description fi ab120363 CDPPB 10mg 50mg >98% PAM for mGlu5. Active in vivo.

ab120039 (R,S)-CHPG 10mg 50mg >98% Selective mGlu5 agonist É ab120221 (R,S)-CHPG sodium salt 10mg 50mg >99% mGlu5 agonist; water soluble

ab120060 CPCCOEt 10mg 50mg >98% Selective, non-competitive mGlu1 antagonist

ab120016 Desmethyl YM298198 hydrochloride 10mg 50mg >99% Analogue of mGlu1 antagonist YM298198 ab120020 (R,S)-3,5-DHPG É 1mg 10mg 50mg >98% Group I mGlu receptor agonist ab120007 (S)-3,5-DHPG É 5mg 10mg >99% Selective group I mGlu agonist

ab120034 Fenobam 10mg 50mg >99% Selective, potent, orally active mGlu5 antagonist fi ab120067 LY 367385 10mg 50mg >99% mGlu1a antagonist É fi ab120418 LY 367385 sodium salt >99% mGlu1a antagonist. Only available in: mGlu antagonists: Kit (ab120322).

ab120201 LY 456236 10mg 50mg >99% mGlu1 non competitive antagonist ab120321 mGlu Agonists Kit É 1kit Kit of mGlu agonists ab120322 mGlu Antagonists Kit 1kit Kit of mGlu antagonists É ab120008 MPEP hydrochloride 10mg 50mg >99% Potent, selective mGlu5 antagonist É ab120035 MTEP hydrochloride 10mg 50mg >99% Potent, selective mGlu5 antagonist

ab120043 PHCCC 10mg 50mg >98% Selective allosteric potentiator at mGlu4. Also group I antagonist. ab120010 Quisqualic acid É 5mg 10mg 50mg >99% Group I mGlu agonist. AMPA agonist. Ç ab120979 Ro 67-4853 10mg 50mg >99% PAM for mGlu1 Ç ab120803 VU 0360223 10mg 50mg >98% Potent mGlu5 antagonist

ab120293 YM 202074 10mg 50mg >98% mGlu1 antagonist É ab120015 YM298198 hydrochloride 10mg 50mg >99% Potent, selective mGlu1 antagonist

Receptors & Transporters: Glutamate: mGlu: Group I & II

Cat No. Product Pack Sizes Purity Description ab120033 (R,S)-MCPG 10mg 50mg >99% Group I /II metabotropic glutamate antagonist ab120059 (S)-MCPG É 10mg 50mg >98% Group I / II mGlu antagonist ab120252 (R,S)-MCPG sodium salt É 10mg 50mg >99% Group I /II metabotropic glutamate antagonist; water soluble ab120321 mGlu Agonists Kit É 1kit Kit of mGlu agonists ab120322 mGlu Antagonists Kit 1kit Kit of mGlu antagonists

Receptors & Transporters: Glutamate: mGlu: Group II

Cat No. Product Pack Sizes Purity Description ab120775 CPPG Ç 10mg 50mg >99% Potent group II/III metabotropic glutamate receptor antagonist ab120818 LY 341495 disodium salt Ç 1mg 10mg 50mg >98% Water-soluble group II/group III mGlu antagonist. Disodium salt of LY 341495 (ab120199) ab120199 LY 341495 fi 1mg 10mg 50mg >98% Potent, selective group II antagonist. Group III antagonist at higher concentrations. ab120400 LY 341495 sodium salt É fi 1mg 10mg 10mg 50mg >98% Water-soluble, potent, selective group II antagonist. Group III antagonist at higher concentrations. ab120173 LY 354740 10mg 50mg >98% Group II mGlu agonist. Systemically active. ab120196 LY 379268 É 10mg 50mg >99% Group II mGlu agonist. Systemically active. ab120321 mGlu Agonists Kit É 1kit Kit of mGlu agonists ab120322 mGlu Antagonists Kit 1kit Kit of mGlu antagonists

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Receptors & Transporters: Glutamate: mGlu: Group III

Cat No. Product Pack Sizes Purity Description

ab120011 AMN082 dihydrochloride 10mg 50mg >99% mGlu7 agonist ab120002 L-AP4 1mg 10mg 50mg >99% Selective group III mGlu agonist Ç ab120506 Cinnabarinic acid 10mg 50mg >98% Endogenous mGlu4 selective agonist ab120775 CPPG Ç 10mg 50mg >99% Potent group II/III metabotropic glutamate receptor antagonist É ab120006 (S)-3,4-DCPG (UBP1109) 10mg 50mg >99% mGlu8a agonist ab120818 LY 341495 disodium salt Ç 1mg 10mg 50mg >98% Water-soluble group II/group III mGlu antagonist. Disodium salt of LY 341495 (ab120199) ab120199 LY 341495 fi 1mg 10mg 50mg >98% Potent, selective group II antagonist. Group III antagonist at higher concentrations. ab120400 LY 341495 sodium salt É fi 1mg 10mg 10mg 50mg >98% Water-soluble, potent, selective group II antagonist. Group III antagonist at higher concentrations. ab120321 mGlu Agonists Kit É 1kit Kit of mGlu agonists ab120322 mGlu Antagonists Kit 1kit Kit of mGlu antagonists

ab120245 MMPIP 1mg 10mg 50mg >98% mGlu7 allosteric antagonist

ab120043 PHCCC 10mg 50mg >98% Selective allosteric potentiator at mGlu4. Also group I antagonist.

ab120244 VU0155041 10mg 50mg >99% PAM for mGluR4 É ab120248 VU0155041 sodium salt 10mg 50mg >99% PAM for mGluR4 (water soluble)

Receptors & Transporters: Glutamate: NMDA: AP-2 binding site

Cat No. Product Pack Sizes Purity Description ab120381 NGHVAEKLSSIE (Control Peptide) É 1mg >94% Control peptide for (ab120380) ab120380 NGHVYEKLSSIE (Interfering peptide) É 1mg >95% Competes with AP-2 binding to NR2B

Receptors & Transporters: Glutamate: NMDA: Glutamate Site

Cat No. Product Pack Sizes Purity Description ab120003 D-AP5 É 1mg 10mg 50mg 100mg >99% NMDA glutamate site antagonist ab120004 DL-AP5 É 10mg 50mg >99% NMDA glutamate site antagonist ab120271 DL-AP5 sodium salt É 10mg 50mg >99% NMDA glutamate site antagonist. Water soluble form. ab120127 CGP 37849 É 10mg 50mg >99% Competitive NMDA antagonist ab120128 CGP 39551 É 10mg 50mg >99% Competitive NMDA antagonist ab120159 (R)-CPP É 10mg 50mg Potent NMDA antagonist ab120160 (R,S)-CPP 10mg 50mg Potent NMDA antagonist ab120232 (R)-CPPene (SDZ EAA 494) É 10mg >98% Potent competitive NMDA antagonist ab120052 NMDA É 50mg 100mg 500mg >98% Excitotoxic amino acid ab120047 cis-PPDA 10mg 50mg >98% GluN2C/GluN2D (formerly NR2C/NR2D) NMDA antagonist ab120193 UBP141 10mg >98% GluN2D (formerly NR2D) antagonist, with some subunit selectivity

Receptors & Transporters: Glutamate: NMDA: Glycine Site

Cat No. Product Pack Sizes Purity Description ab120024 7-Chlorokynurenic acid 10mg 50mg >99% NMDA receptor glycine site antagonist ab120255 7-Chlorokynurenic acid sodium salt É 10mg 50mg >99% NMDA receptor glycine site antagonist; water soluble ab120017 CNQX 10mg 25mg 50mg >99% AMPA / kainate antagonist ab120044 CNQX disodium salt É 1mg 10mg 50mg >99% AMPA / kainate antagonist (water soluble) ab120121 D-Cycloserine É 50mg 250mg >99% NMDA glycine site agonist ab120023 5,7-Dichlorokynurenic acid 10mg 50mg 100mg >99% NMDA receptor glycine site antagonist ab120254 5,7-Dichlorokynurenic acid sodium salt É 10mg 50mg 100mg >99% NMDA receptor glycine site antagonist; water soluble ab120048 D-Serine É 1g 5g >98% Endogenous NMDA receptor co-agonist

Receptors & Transporters: Glutamate: NMDA: Ion Channel Site

Cat No. Product Pack Sizes Purity Description ab141028 Dextromethorphan hydrobromide Ç 50mg >99% Non-competitive, low affinity NMDA receptor antagonist ab120249 Memantine hydrochloride É 50mg >98% NMDA antagonist, ion channel site ab120027 (+)-MK 801 maleate (Dizocilpine) É 10mg 50mg >99% Non-competitive NMDA antagonist ab120028 (-)-MK 801 maleate É 10mg 50mg >99% Non competitive NMDA antagonist; less active enantiomer

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Receptors & Transporters: Glutamate: NMDA: Polyamine Site

Cat No. Product Pack Sizes Purity Description ab120111 Ifenprodil 10mg 50mg >99% GluN2B (formerly NR2B)-preferring NMDA antagonist ab120290 Ro 25-6981 maleate salt É 1mg 10mg 50mg >98% NR2B antagonist ab120057 Spermidine hydrochloride É 100mg >99% Endogenous polyamine. nNOS inhibitor. ab120051 Spermine É 100mg 1g >99% Endogenous polyamine

Receptors & Transporters: Glutamate: Transporters

Cat No. Product Pack Sizes Purity Description ab120066 Dihydrokainic acid É 1mg 10mg 50mg >99% EAAT2 inhibitor ab120869 Evans blue Ç 1g >95% Potent inhibitor of L-glutamate uptake ab120272 Riluzole (PK 26124) É 10mg 50mg >99% Neuroprotective agent. Modulates glutamate transmission. ab120309 UCPH-101 fi 1mg 10mg >98% Potent, selective EAAT1 inhibitor

Receptors & Transporters: Glycine

Cat No. Product Pack Sizes Purity Description ab120870 β-Alanine Ç 1g >98% Endogenous glycine agonist ab120346 N-Arachidonylglycine (NAGly) 5mg 25mg 100mg >98% T-type Ca2+ channel blocker. Endogenous GLYT2 inhibitor. ab120050 Glycine É 100mg 1g >99% Inhibitory neurotransmitter

ab120315 Picrotoxin 1g 5g GABAA antagonist ab120416 Strychnine hydrochloride É 100mg >99% Glycine antagonist

Receptors & Transporters: Histamine

Cat No. Product Pack Sizes Purity Description Ç ab118175 Aminopotentidine fluorescent ligand (Red) 50μg 100μg >97% Fluorescent H2 antagonist Ç ab120778 Amthamine dihydrobromide 10mg 50mg >99% Selective H2 agonist ab120576 Asenapine maleate Ç 10mg 50mg >99% Multiple receptor antagonist. Anti-psychotic agent. Ç É ab120729 (±)-Chlorpheniramine maleate 100mg >99% Potent H1 antagonist and SNRI ab120730 Chlorpromazine hydrochloride Ç É 1g 5g >99% Typical antipsychotic. Non-selective receptor antagonist. Ç É ab120731 Cimetidine 100mg >99% Prototypic H2 antagonist. I1 agonist. Ç ab120779 Ciproxifan maleate 5mg 25mg >98% Potent prototypic H3 inverse agonist / antagonist Ç ab120780 Clobenpropit dihydrobromide 10mg 50mg >99% Selective H3 antagonist Ç ab118649 Clobenpropit fluorescent ligand (Red) 50μg 100μg Fluorescent H3 antagonist Ç É ab120732 Cyproheptadine hydrochloride 50mg 100mg >99% Potent H1 and 5-HT2B antagonist. Non-selective receptor antagonist. Ç ab120855 Dimaprit dihydrochloride 100mg >98% Selective H2 antagonist Ç É ab120733 Diphenhydramine hydrochloride 500mg 1g >99% Potent H1 antagonist Ç ab120760 Famotidine 500mg 1g >99% Selective H2 antagonist Ç ab120765 Fexofenadine hydrochloride 10mg 50mg >99% Selective H1 receptor antagonist ab120734 Histamine dihydrochloride Ç É 50mg 250mg Endogenous histamine receptor agonist ab141127 HTMT (Histamine trifluoromethyl toluidide) Ç dimaleate 10mg 50mg >99% H1/H2 receptor agonist. More potent than histamine. Ç ab120857 Imetit dihydrobromide 10mg 50mg Highly potent H3 and H4 receptor agonist

ab120191 JNJ 10191584 maleate (VUF 6002) 10mg 50mg >99% Selective H4 antagonist Ç ab120782 Ketotifen fumarate 100mg >99% Selective, H1 antagonist Ç ab120766 Loratidine 10mg 50mg >99% H1 receptor antagonist Ç ab118174 Mepyramine fluorescent ligand (Red) 50μg 100μg >97% Fluorescent H1 antagonist Ç É ab120735 Mepyramine maleate 100mg >99% Selective H1 inverse agonist Ç ab120788 Mianserin hydrochloride 50mg >99% Multiple receptor antagonist. Activity at 5-HT2,

H1 and α2 receptors. ab120736 Olanzapine Ç 10mg 50mg >99% Non-selective 5-HT, dopamine, histamine and muscarinic antagonist. Ç É ab120738 Ranitidine hydrochloride 10mg 50mg >99% Selective H2 antagonist ab141190 Sinomenine hydrochloride Ç 50mg >99% Natural anti-inflammatory morphinan analog; potently releases histamine + ab120270 Terfenadine 100mg >98% K channel blocker. H1 antagonist. É ab120021 Thioperamide maleate 10mg 50mg >99% Potent, selective H3 antagonist Ç ab141128 VUF8430 dihydrobromide 10mg 50mg Potent and high affinity H4 receptor agonist

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Receptors & Transporters: Imidazoline

Cat No. Product Pack Sizes Purity Description Ç É ab120731 Cimetidine 100mg >99% Prototypic H2 antagonist. I1 agonist. Ç É ab120753 Clonidine hydrochloride 100mg >99% α2 adrenoceptor agonist ab120605 Harmane Ç 100mg >99% β-Carboline. Imidazoline ligand. MAO inhibitor. Ç ab141130 Idazoxan hydrochloride 10mg 50mg >99% α2-adrenoceptor antagonist and I2 ligand Ç ab120789 Moxonidine hydrochloride 10mg 50mg >99% I1 imidazoline receptor and α2 adrenergic agonist

Receptors & Transporters: Melatonin

Cat No. Product Pack Sizes Purity Description Ç ab141052 Melatonin 50mg >99% Endogenous hormone; agonist at MT1 and

MT2 receptors ab120238 Prazosin hydrochloride 50mg 250mg >99% α-adrenoceptor antagonist. Melatonin antagonist.

Receptors & Transporters: Muscarinic

Cat No. Product Pack Sizes Purity Description ab120469 Acetylcholine chloride É 50mg 5g Endogenous neurotransmitter active at acetylcholine receptors Ç ab120146 AF-DX 384 10mg 50mg >99% M2/M4 antagonist

ab120152 AF-DX 116 (Otenzepad) 10mg 50mg >99% M2 antagonist

ab120151 AQ-RA 741 10mg 50mg >99% M2 antagonist ab141044 Arecoline hydrobromide Ç 250mg >99% Muscarinic receptor agonist ab141045 Bethanechol chloride Ç 5g >98% Muscarinic receptor agonist Ç ab141042 Brucine 5g >98% Positive allosteric modulator at M1 receptors. ab120730 Chlorpromazine hydrochloride Ç É 1g 5g >99% Typical antipsychotic. Non-selective receptor antagonist. ab120019 Clozapine 50mg 500mg >99% Atypical antipsychotic Ç É ab120732 Cyproheptadine hydrochloride 50mg 100mg >99% Potent H1 and 5-HT2B antagonist. Non-selective receptor antagonist. ab120144 4-DAMP 25mg 100mg >98% Muscarinic receptor antagonist

ab120026 N-Desmethyl clozapine (Normethylclozapine) 10mg 50mg >99% Clozapine metabolite. M1 agonist. D2/D3 agonist. ab141046 Imipramine hydrochloride Ç 5g >98% Tricyclic antidepressant ab120736 Olanzapine Ç 10mg 50mg >99% Non-selective 5-HT, dopamine, histamine and muscarinic antagonist. É ab120153 Pirenzepine dihydrochloride 100mg 500mg >99% M1 antagonist Ç ab118176 Pirenzepine fluorescent ligand (Red) 50μg 100μg >97% Fluorescent M3 antagonist ab141080 Scopolamine hydrobromide Ç 1g >99% Competitive, non-selective muscarinic antagonist Ç ab141043 Tropicamide 100mg >98% Potent, selective M4 antagonist Ç ab141078 Xanomeline oxalate 10mg 50mg >99% Functionally preferring M1 muscarinic acetylcholine receptor agonist

Receptors & Transporters: Nicotinic

Cat No. Product Pack Sizes Purity Description ab120469 Acetylcholine chloride É 50mg 5g Endogenous neurotransmitter active at acetylcholine receptors ab120838 Amyloid β Peptide (12-28) Ç 500μg 1mg >95% Toxic amyloid β peptide fragment ab120013 (±)-Anatoxin A fumarate É 1mg >98% Potent nicotinic agonist ab120542 α-Bungarotoxin Ç 1mg >99% Subtype-selective α7 nAChR antagonist ab120534 Bupropion hydrochloride Ç É 50mg 250mg 1g >98% Non-selective DAT/NET inhibitor ab120537 (-)-Cytisine Ç É 10mg 50mg >99% Potent, selective nAChR agonist ab120560 GTS-21 dihydrochloride (DMBX-A) Ç 10mg 50mg >98% α7 nicotinic acetylcholine receptor agonist Ç É ab120538 Hexamethonium bromide 100mg 1g Antagonist at α3-containing nAChR ab120599 5-Iodo A85380 dihydrochloride Ç 5mg 25mg >98% Potent α4β2 and α6β2 receptor agonist ab120064 Kynurenic acid 1g >99% Endogenous ionotropic / nicotinic antagonist ab120256 Kynurenic acid sodium salt É 1g 5g >99% Endogenous ionotropic / nicotinic antagonist; water soluble ab120459 Mecamylamine hydrochloride É 10mg 50mg Non-competitive antagonist of nicotinic receptors ab120072 Methyllycaconitine citrate (MLA) É 5mg 25mg >98% α7-nicotinic receptor antagonist ab120562 (-)-Nicotine ditartrate Ç É 50mg >99% Potent nAChR agonist ab120535 Pancuronium dibromide Ç É 10mg 50mg 250mg Competitive nicotinic acetylcholine receptor (nAChR) antagonist ab120559 PNU 120596 Ç 10mg 50mg >99% Positive allosteric modulator for the α7 nicotinic acetylcholine receptor ab120558 PNU 282987 Ç 10mg 50mg >99% Selective α7 nAChR agonist

Discover more at www.abcam.com/biochemicals 15 Catalog Update01 - International_Update 31/01/2013 08:18 Page 16

Receptors & Transporters: Nicotinic

Cat No. Product Pack Sizes Purity Description ab120450 RuBi-nicotine É 5mg Novel, caged nicotine compound, uncaged by visible light ab120553 S 24795 Ç 10mg 50mg >99% Partial α7 nAChR agonist ab120416 Strychnine hydrochloride É 100mg >99% Glycine antagonist ab120557 TC-2403 oxalate Ç É 10mg 50mg >99% Potent α4β2 nAChR selective agonist É ab120156 Tropisetron hydrochloride 10mg 50mg >99% 5-HT3 antagonist ab120073 (+)-Tubocurarine É 10mg 50mg >99% ACh receptor antagonist ab120536 Vecuronium bromide Ç 10mg 50mg 250mg Competitive nicotinic acetylcholine receptor (nAChR) antagonist

Receptors & Transporters: Nuclear Receptors

Cat No. Product Pack Sizes Purity Description ab141024 AM 80 Ç 10mg 50mg >98% Selective retinoic acid receptor α/β (RARα/β) agonist ab141025 Bexarotene Ç fi 10mg 50mg >99% Potent RXR agonist ab141233 Bezafibrate Ç 1g 5g >99% Pan-PPAR agonist ab141249 Bicalutamide (ICI176334) Ç 10mg 50mg >99% Non-steroidal, competitive androgen receptor antagonist ab120833 Clofibric acid Ç 1g >99% PPARα agonist ab141183 Clomiphene citrate Ç 1g >98% Selective estrogen receptor modulator (SERM) ab120391 Daidzein 50mg >99% Phytoestrogen ab120743 Dexamethasone Ç 100mg >99% Anti-inflammatory glucocorticoid ab120166 DPN 10mg 50mg >99% Potent, selective ERβ agonist ab120390 Equol 5mg 25mg >99% Metabolite of phytoestrogen daidzein ab120657 17β-Estradiol Ç 100mg 1g >99% Selective agonist of ER receptor ab120832 Fenofibrate Ç 5g >99% Potent, selective PPAR-α agonist ab120826 GSK 4716 Ç 10mg 50mg >99% Selective ERRβγ agonist ab141250 Hydrocortisone Ç 1g 5g >99% Adrenal glucocorticoid; immunosuppressant ab120131 ICI 182,780 10mg 50mg >99% Estrogen receptor antagonist ab120719 Indomethacin Ç 100mg >99% Non-selective COX inhibitor ab120356 Mifepristone (RU486) 100mg 500mg >98% PR and GR antagonist ab120794 Pioglitazone hydrochloride Ç 10mg 50mg >99% Selective PPAR-γ agonist ab120161 PPT 10mg 50mg >99% Subtype selective ERα agonist ab141252 Progesterone Ç 100mg >99% Endogenous progesterone receptor agonist ab141023 9-cis-Retinoic acid Ç 1mg >98% High affinity, endogenous retinoic acid receptor agonist ab120762 Rosiglitazone Ç 10mg 50mg >99% Selective PPARγ agonist ab120876 T0070907 Ç 10mg 50mg >98% Potent, selective PPARγ antagonist ab120656 Tamoxifen citrate Ç 100mg 1g >99% Estrogen receptor antagonist and partial agonist Ç ab120831 Telmisartan 10mg 50mg >99% Selective angiotensin II (AT1) antagonist

Receptors & Transporters: Opioids

Cat No. Product Pack Sizes Purity Description ab120078 nor-Binaltorphimine (nor-BNI) É 10mg 50mg >98% Potent and selective κ opioid receptor antagonist ab120669 BRL 52537 hydrochloride Ç 10mg 50mg >99% Highly selective, potent κ-opioid agonist ab120680 CTAP Ç 1mg >95% Potent, selective μ opioid antagonist ab120417 CTOP É 1mg >95% Potent, selective μ opioid receptor antagonist. ab120673 DADLE Ç 1mg 5mg >95% δ-opioid peptide agonist ab120674 DAMGO Ç 1mg 5mg >95% Potent and selective μ opioid receptor agonist ab120708 [DAla2]Deltorphin II Ç 1mg >98% Selective δ opioid receptor agonist ab120675 DPDPE Ç 1mg 5mg >95% Potent, selective δ opioid receptor agonist ab120412 Dynorphin A É 1mg >99% Potent κ agonist ab120681 Dynorphin B Ç 1mg >97% Endogenous opioid peptide. κ opioid agonist. ab120411 Endomorphin-1 É 5mg >99% Highly potent and selective μ agonist ab120676 Endomorphin 2 Ç 5mg >95% Potent, selective μ opioid receptor agonist ab120147 Herkinorin 1mg >98% Non-internalising μ opioid agonist ab120713 Loperamide hydrochloride Ç 1g >99% Selective μ opioid receptor agonist ab120074 Naloxone hydrochloride É 100mg 250mg >98% Opioid antagonist ab120075 Naltrexone hydrochloride É 100mg 250mg >98% Opioid antagonist ab120070 Nociceptin (Orphanin FQ) É 1mg 5mg >95% ORL1 agonist Ç ab120682 Nociceptin (1-13) NH2 1mg >98% Potent ORL1 agonist Ç É ab120741 Nociceptin (1-7) (Orphanin FQ (1-7)) 1mg >95% Bioactive fragment of nociceptin. ORL1 (NOP) receptor agonist. ab120084 Salvinorin A (Divinorin A) 1mg 5mg >99% Potent κ agonist ab120684 SNC80 Ç 10mg 50mg >99% Highly potent, selective δ opioid receptor agonist

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Receptors & Transporters: Orphan 7-TM Receptors

Cat No. Product Pack Sizes Purity Description ab120940 Zaprinast Ç 10mg 50mg >98% Specific cGMP phosphodiesterase inhibitor

Receptors & Transporters: Peptide Receptors

Cat No. Product Pack Sizes Purity Description ab141150 AC187 Ç 500μg >98% Potent, selective amylin receptor antagonist ab141151 ACTH (1-39) (human) Ç 1mg >98% Potent, endogenous melanocortin receptor 2

(MC2) agonist ab120183 Angiotensin II (human) É 5mg 25mg >95% Vasoconstrictor peptide ab141010 Apelin 13 Ç 1mg >95% Selective endogenous apelin receptor (APJ) ligand ab141012 Pyr1-Apelin 13 Ç 1mg >95% Highly potent, selective endogenous apelin receptor (APJ) agonist ab141011 Apelin 17 Ç 1mg >95% Endogenous apelin receptor (APJ) agonist ab141009 Apelin 36 (human) Ç 1mg >95% Endogenous apelin receptor (APJ) agonist ab120179 AY-NH2 É 1mg 5mg >95% PAR4 agonist peptide ab120178 BAM (8-22) (Bovine Adrenal Medulla 8-22) É 1mg >95% SNSR agonist Ç ab141005 BQ-123 500μg >95% Potent, selective ETA receptor antagonist ab120470 Bradykinin É 1mg 5mg 10mg 25mg >98% Bradykinin receptor agonist ab120209 CCK Octapeptide sulfated É 1mg >95% C-terminal ocatapeptide of CCK ab120471 Endothelin-1 (human, porcine) Ç 10μg 100μg 500μg >97% Vasoconstrictor peptide ab120214 Exendin-4 (Exenatide) É 500μg 1mg >99% Potent GLP-1 receptor agonist Ç ab120800 2-Furoyl-LIGRLO-amide (2Fly) 1mg >95% Potent and selective PAR2 agonist ab141152 Galanin (1-15) (porcine, rat) Ç 1mg >98% Galanin receptor peptide agonist ab120172 Galanin (1-16) (porcine, rat) É 500μg 1mg >95% N-terminal galanin fragment ab141153 Galanin (1-29) (rat, mouse) Ç 1mg >98% Non-selective galanin receptor agonist ab141174 Galanin (porcine) Ç 1mg >98% Endogenous galanin receptor agonist ab141072 Gastrin I (human) Ç 1mg >97% Selective CCK2 agonist ab120230 Ghrelin (human) É 1mg >95% Endogenous GHS agonist ab120231 Ghrelin (rat) É 1mg >95% Endogenous GHS agonist ab141148 [D-Lys3]-GHRP-6 (DLS) Ç 5mg >99% Ghrelin receptor (GHS-R1a) and CCR5 antagonist ab141175 GIP (1-39) (porcine) Ç 1mg >98% Truncated endogenous gastric inhibitory peptide (GIP) ab141176 GIP (human) Ç 1mg >98% Endogenous gastric inhibitory peptide (GIP) ab141103 GRP (human) Ç 1mg >95% Endogenous GRP receptor agonist ab120181 Kisspeptin-13 (4-13) (human) (KiSS-1 (112-121)) É 1mg >95% AXOR12 agonist ab120188 Locustatachykinin I É 1mg >95% Insect tachykinin-related peptide Ç ab120997 Losartan potassium 50mg >99% Selective non-peptide angiotensin II AT1 receptor antagonist ab120184 Luteinizing Hormone Releasing Hormone (LHRH) É 5mg 25mg >95% Reproductive hormone ab141155 Lys-γ3-MSH (human) Ç 1mg >98% Pro-opiomelanocortin (POMC) derived peptide Ç ab141156 M1145 500μg >98% Potent, selective GAL2 agonist ab141157 M40 Ç 1mg >98% Potent, non-selective galanin receptor antagonist Ç ab141158 M617 1mg >98% Selective galanin GAL1 receptor agonist Ç ab141159 M871 1mg >98% Selective galanin GAL2 receptor antagonist ab141161 Melanotan II Ç 1mg >99% Potent, high affinity melanocortin receptor agonist ab141177 Motilin (human, porcine) Ç 1mg >98% Gastrointestinal peptide and potent motilin receptor ligand ab120205 α-MSH (free acid) É 5mg >95% Endogenous melanocortin receptor agonist ab120189 α-MSH (α-Melanocyte-stimulating hormone) É 1mg 5mg >95% Endogenous melanocortin receptor agonist ab120185 Neurokinin A É 5mg 25mg >95% Tachykinin peptide ab141073 Neuromedin B (porcine) Ç 1mg >98% Bombesin-like peptide; endogenous ligand for the neuromedin B receptor ab141008 Neuromedin S (human) (NMS) Ç 1mg >95% Potent, neuromedin U (NMU) receptor agonist ab141007 Neuromedin U-25 (human) (NMU) Ç 500μg >95% Endogenous neuropeptide with multiple biological effects Ç ab141178 Neuropeptide FF (NPFF) 1mg >99% Endogenous neuropeptide, NPFF1 and NPFF2 agonist ab120174 Neuropeptide S (mouse) É 1mg >95% NPS receptor agonist ab120246 Neuropeptide S (rat) É 1mg >95% NPS receptor agonist ab141162 Neuropeptide SF (human) Ç 1mg >98% Endogenous anti-opiate neuropeptide. Ç ab141163 Neuropeptide SF (mouse, rat) 1mg >98% NPFF1 and NPFF2 agonist ab120208 Neuropeptide Y (NPY) (human, rat) É 500μg 1mg >95% Endogenous neuropeptide É ab120171 Neuropeptide Y 13-36 (porcine) 1mg 5mg >95% NPY Y2 agonist ab141173 Neurotensin Ç 1mg >98% Endogenous neuropeptide and endocrine modulator

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Receptors & Transporters: Peptide Receptors

Cat No. Product Pack Sizes Purity Description ab120071 Obestatin É 1mg >95% Endogenous peptide involved in feeding ab141208 Octreotide Ç 1mg >99% Somatostatin analog ab120212 Orexin A (bovine, human, mouse, rat) É 100μg 500μg 1mg >99% Neuropeptide involved in feeding and sleep Ç ab141104 Orexin B (mouse) 500μg >95% Endogenous neuropeptide. OX2 agonist. ab120186 Oxytocin É 5mg 25mg >95% Reproductive hormone ab120204 Oxytocin (free acid) É 5mg >95% Reproductive hormone ab120483 Psalmotoxin-1 É 20μg 100μg >95% Potent, selective ASIC1a blocker Ç ab141105 SB 408124 10mg >98% Selective, non-peptide OX1 antagonist Ç ab120858 SCH79797 dihydrochloride 10mg 50mg >98% Potent and selective PAR1 antagonist ab141074 Secretin (human) Ç 1mg >98% Endogenous secretin peptide Ç ab141164 SHU9119 1mg >99% Potent melanocortin 3 and 4 (MC3 and MC4) receptor antagonist ab120176 SLIGRL-NH2 É 1mg >98% PAR2 agonist peptide ab141147 [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P Ç 1mg >99% Broad spectrum neuropeptide antagonist/inverse agonist ab120170 Substance P É 1mg 5mg >95% Sensory neuropeptide Ç ab120831 Telmisartan 10mg 50mg >99% Selective angiotensin II (AT1) antagonist ab120177 TFLLR-NH2 É 1mg >95% PAR1 agonist peptide Ç ab120801 TRAP-6 5mg >96% PAR1 agonist ab120175 (Arg-8)-Vasopressin (AVP) É 1mg 5mg >95% Vasopressin receptor agonist ab120180 VIP (Vasoactive Intestinal Peptide) (6-28) É 1mg >95% VPAC antagonist Ç ab141149 [D-Trp8]-γ-MSH 1mg >98% Selective melanocortin 3 (MC3) receptor agonist Ç ab141165 γ1-MSH 1mg >98% Selective melanocortin receptor 3 (MC3) agonist

Receptors & Transporters: Prostanoid

Cat No. Product Pack Sizes Purity Description Ç ab120905 AH 6809 10mg 50mg >98% EP1 and EP2 antagonist ab120916 Arachidonic acid Ç 50mg 100mg >98% ω-6 polyunsaturated fatty acid, precursor of eicosanoids Ç ab141034 (±)-Cloprostenol sodium 10mg >99% Potent, water soluble PGF2α analog ab120906 16,16-Dimethyl prostaglandin E2 Ç 1mg 5mg >98% Competitive 15-hydroxy PGDH inhibitor. Synthetic

derivative of prostaglandin E2. Ç ab120911 Iloprost 1mg 5mg >97% Prostaglandin (PGI2) analogue Ç ab120947 L-161,982 10mg 50mg >98% Potent and selective EP4 receptor antagonist Ç ab120946 L-655,240 1mg 5mg >98% Potent thromboxane A2 receptor antagonist Ç ab120902 Misoprostol 1mg 10mg >98% Cytoprotective PGE2 analog Ç ab120879 Prostaglandin A2 1mg 5mg >98% Endogenous metabolite derived from arachidonic acid Ç ab120888 Prostaglandin D2 1mg 5mg >99% High affinity DP1 and CRTH2 receptor agonist; major prostaglandin produced by mast cells. Ç ab120909 Prostaglandin G2 100μg 500μg >95% Major prostanoid in the COX pathway. Ç ab120910 Prostaglandin H2 100μg 500μg >95% Major prostanoid; important precursor in eicosanoid synthesis Ç ab120912 Prostaglandin I2 sodium salt 1mg 5mg >99% Potent vasodilator and inhibitor of platelet aggregation Ç ab120913 Prostaglandin J2 1mg 5mg >95% Endogenous product of inflammation; PGD2 analog Ç ab120907 Sulprostone 1mg 5mg >98% Selective EP1/ EP3 receptor agonist. PGE2 analog. Ç ab120908 U-51605 100μg 500μg >98% Selective PGI2 and TXA2 synthase inhibitor. PGH2 analog.

Receptors & Transporters: Serotonin: 5-HT1

Cat No. Product Pack Sizes Purity Description Ç É ab120520 BMY 7378 dihydrochloride 10mg 50mg >99% 5-HT1A partial agonist. α-adrenoceptor antagonist. Ç ab120517 BRL 15572 monohydrochloride 10mg 50mg >98% Selective 5-HT1D receptor antagonist Ç ab120627 BRL 54443 10mg 50mg >99% Selective agonist at 5-HT1E and 5-HT1F receptors Ç ab141235 BRL 54443 maleate salt 10mg 50mg >99% Selective, high affinity 5-ht1e and 5-HT1F receptor agonist

ab120420 Buspirone hydrochloride 1g 5g >99% 5HT1A agonist. Anxiolytic. Ç É ab120522 CP 94253 dihydrochloride 10mg 50mg >98% Highly potent, selective 5-HT1B agonist ab120507 (R)-(+)-8-Hydroxy-DPAT hydrobromide É (8-Hydroxy DPAT) 10mg 50mg >98% Selective full 5-HT1A receptor agonist Ç ab120582 8-Hydroxy-DPAT hydrobromide 10mg 50mg >99% Standard selective 5-HT1a receptor agonist; affinity

for 5-HT7 receptors

ab120349 GR 125743 10mg >99% 5HT1B/1D antagonist Ç É ab120523 GR 127935 hydrochloride 10mg 50mg >99% Potent, selective 5-HT1B/1D receptor antagonist Ç ab120586 GR 46611 10mg 50mg >99% 5-HT1B/1D agonist Ç É ab120513 GR 55562 dihydrochloride 10mg 50mg >99% Selective 5-HT1B / 5-HT1D receptor antagonist

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Receptors & Transporters: Serotonin: 5-HT1

Cat No. Product Pack Sizes Purity Description Ç ab120515 L-694,247 10mg 50mg >99% Highly potent 5-HT1D/5-HT1B receptor agonist Ç É ab120524 LY 310762 hydrochloride 10mg 50mg >99% Potent, 5-HT1D antagonist Ç fi ab120592 LY 344864 hydrochloride 10mg 50mg >99% Selective, potent 5-HT1F agonist Ç ab120543 NAN-190 hydrobromide 50mg 250mg >99% Potent 5-HT1A antagonist Ç ab118177 NAN-190 Fluorescent ligand (Red) 50μg 100μg >97% Fluorescent 5-HT1A antagonist

ab120521 Pindolol 250mg 1g >99% 5-HT1A and 5-HT1B receptor antagonist ab120601 Rotigotine hydrochloride Ç É 10mg 50mg >99% Dopamine receptor agonist Ç É ab120583 SB 216641 hydrochloride 10mg 50mg >98% Selective h5-HT1B antagonist É ab120514 Sumatriptan succinate 10mg 50mg >99% 5-HT1 receptor agonist Ç ab120550 WAY-100635 maleate 10mg 50mg >98% Potent, selective, silent 5-HT1A receptor antagonist Ç ab118650 ZM549865 fluorescent ligand (Red) 50μg 100μg Fluorescent 5-HT1B antagonist

Receptors & Transporters: Serotonin: 5-HT2

Cat No. Product Pack Sizes Purity Description ab120730 Chlorpromazine hydrochloride Ç É 1g 5g >99% Typical antipsychotic. Non-selective receptor antagonist. Ç É ab120732 Cyproheptadine hydrochloride 50mg 100mg >99% Potent H1 and 5-HT2B antagonist. Non-selective receptor antagonist. É ab120132 Ketanserin tartrate 50mg 250mg >98% Selective 5HT2 antagonist. Ç ab120546 LY 272015 hydrochloride 10mg 50mg >99% Highly potent, selective 5-HT2B antagonist Ç ab120788 Mianserin hydrochloride 50mg >99% Multiple receptor antagonist. Activity at 5-HT2,

H1 and α2 receptors.

ab120068 Mirtazapine 10mg 50mg >99% Antidepressant. α2, 5HT2, 5HT3 antagonist Ç ab120587 Nefazodone hydrochloride 10mg 50mg >99% Potent 5-HT2A antagonist ab120736 Olanzapine Ç 10mg 50mg >99% Non-selective 5-HT, dopamine, histamine and muscarinic antagonist. Ç ab120737 Quetiapine hemifumarate 10mg 50mg >99% D2 and 5-HT2 antagonist. Antipsychotic.

ab120393 Risperidone 10mg 50mg >99% Atypical antipsychotic. 5HT2A / D2 antagonist. Ç ab120585 RS 127445 hydrochloride 10mg 50mg >99% Selective, potent 5-HT2B antagonist Ç ab120595 SB 204741 10mg 50mg >99% Selective 5-HT2B receptor antagonist Ç ab120556 SB 206553 hydrochloride 10mg 50mg >99% Potent, selective 5-HT2B and 5-HT2C receptor agonist Ç ab120519 SB 242084 hydrochloride 10mg 50mg >99% Potent, selective 5-HT2C antagonist

ab120394 Ziprasidone (CP 88059) 10mg 50mg >99% Atypical antipsychotic. 5HT2A / D2 antagonist. Ç É ab120555 α-Methyl 5-hydroxytryptamine maleate 10mg 50mg 100mg >99% 5-HT2A/2C receptor agonist

Receptors & Transporters: Serotonin: 5-HT3

Cat No. Product Pack Sizes Purity Description É ab120125 Granisetron 50mg 250mg >99% 5HT3 antagonist

ab120068 Mirtazapine 10mg 50mg >99% Antidepressant. α2, 5HT2, 5HT3 antagonist ab120736 Olanzapine Ç 10mg 50mg >99% Non-selective 5-HT, dopamine, histamine and muscarinic antagonist.

ab120134 Ondansetron 10mg 50mg >98% Selective 5HT3 antagonist.

ab120511 1-Phenylbiguanide 100mg 1g >99% 5HT3 receptor agonist ab120540 Quipazine dimaleate Ç É 50mg 250mg >99% 5-HT receptor agonist É ab120156 Tropisetron hydrochloride 10mg 50mg >99% 5-HT3 antagonist

Receptors & Transporters: Serotonin: 5-HT4

Cat No. Product Pack Sizes Purity Description Ç ab120548 Cisapride 10mg 50mg >99% 5-HT4 receptor agonist. hERG blocker. Ç ab120544 GR113808 10mg 50mg >99% Potent, highly selective 5-HT4 antagonist

Receptors & Transporters: Serotonin: 5-HT5

Cat No. Product Pack Sizes Purity Description Ç ab120590 SB 699551 dihydrochloride 10mg 50mg >99% Selective 5-HT5A receptor antagonist

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Receptors & Transporters: Serotonin: 5-HT6

Cat No. Product Pack Sizes Purity Description ab120730 Chlorpromazine hydrochloride Ç É 1g 5g >99% Typical antipsychotic. Non-selective receptor antagonist. É ab120328 EMD 386088 hydrochloride 10mg 50mg >99% Potent 5HT6 agonist Ç ab120589 SB 271046 hydrochloride 10mg 50mg >99% Potent, selective 5-HT6 antagonist É ab120332 SB 399885 hydrochloride 10mg 50mg >99% Potent, selective 5HT6 antagonist

Receptors & Transporters: Serotonin: 5-HT7

Cat No. Product Pack Sizes Purity Description ab120730 Chlorpromazine hydrochloride Ç É 1g 5g >99% Typical antipsychotic. Non-selective receptor antagonist. Ç ab120582 8-Hydroxy-DPAT hydrobromide 10mg 50mg >99% Standard selective 5-HT1a receptor agonist; affinity

for 5-HT7 receptors Ç ab120594 LP-12 hydrochloride 10mg 50mg >98% 5-HT7 agonist Ç ab120593 LP-44 10mg 50mg >99% Highly potent, selective 5-HT7 agonist Ç ab120508 SB 269970 hydrochloride 10mg 50mg >98% Potent, selective 5-HT7 receptor antagonist

Receptors & Transporters: Serotonin: Non-selective

Cat No. Product Pack Sizes Purity Description ab120576 Asenapine maleate Ç 10mg 50mg >99% Multiple receptor antagonist. Anti-psychotic agent. Ç ab120564 Cabergoline 10mg 50mg >99% D2-like receptor agonist ab120019 Clozapine 50mg 500mg >99% Atypical antipsychotic Ç É ab120732 Cyproheptadine hydrochloride 50mg 100mg >99% Potent H1 and 5-HT2B antagonist. Non-selective receptor antagonist.

ab120026 N-Desmethyl clozapine (Normethylclozapine) 10mg 50mg >99% Clozapine metabolite. M1 agonist. D2/D3 agonist. ab141046 Imipramine hydrochloride Ç 5g >98% Tricyclic antidepressant ab120526 Metergoline Ç 10mg 50mg >99% Potent 5-HT receptor antagonist ab120591 5-Methyltryptamine hydrochloride Ç 250mg >99% 5-HT agonist ab120530 Methysergide maleate É 10mg 50mg >99% 5-HT receptor antagonist Ç ab120788 Mianserin hydrochloride 50mg >99% Multiple receptor antagonist. Activity at 5-HT2,

H1 and α2 receptors. ab120540 Quipazine dimaleate Ç É 50mg 250mg >99% 5-HT receptor agonist ab120528 Serotonin hydrochloride (5-HT/5-Hydroxytryptamine) É 50mg 250mg 1g >99% Endogenous neurotransmitter, 5HT receptor agonist É ab120549 Spiperone hydrochloride 50mg 250mg >99% 5-HT and D2-like receptor antagonist

Receptors & Transporters: Serotonin: Transporters

Cat No. Product Pack Sizes Purity Description ab120534 Bupropion hydrochloride Ç É 50mg 250mg 1g >98% Non-selective DAT/NET inhibitor Ç É ab120729 (±)-Chlorpheniramine maleate 100mg >99% Potent H1 antagonist and SNRI ab120133 Citalopram É 25mg 100mg >98% 5-HT reuptake inhibitor ab120077 Fluoxetine hydrochloride É 10mg 50mg >99% 5-HT reuptake inhibitor ab141082 Fluvoxamine maleate Ç 10mg 50mg >99% Potent, selective serotonin reuptake inhibitor (SSRI) ab141046 Imipramine hydrochloride Ç 5g >98% Tricyclic antidepressant ab120755 Milnacipran hydrochloride Ç É 10mg 50mg >99% Serotonin and norepinephrine reuptake inhibitor ab120069 Paroxetine hydrochloride 10mg 50mg >99% 5-HT uptake inhibitor ab141068 Sertraline hydrochloride Ç 10mg 50mg >99% Selective serotonin reuptake inhibitor ab120529 Sibutramine hydrochloride Ë 10mg 50mg >98% Serotonin, noradrenaline & dopamine re-uptake inhibitor ab120715 Venlafaxine hydrochloride Ç É 10mg 50mg >99% Serotonin-norepinephrine reuptake inhibitor

Receptors & Transporters: Sigma

Cat No. Product Pack Sizes Purity Description ab141082 Fluvoxamine maleate Ç 10mg 50mg >99% Potent, selective serotonin reuptake inhibitor (SSRI)

Receptors & Transporters: Smoothened

Cat No. Product Pack Sizes Purity Description ab120904 GANT 61 Ç 10mg 50mg >98% Selective GLI1 and 2 inhibitor ab120815 Jervine Ç 1mg 5mg >98% Smoothened inhibitor ab120933 Purmorphamine Ç 5mg 25mg >98% Smoothened receptor agonist

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Receptors & Transporters: Sphingosine 1-Phosphate Receptors

Cat No. Product Pack Sizes Purity Description Ç ab120983 SEW 2871 10mg 50mg >98% Potent, selective S1P1 agonist

Receptors & Transporters: TGR5

Cat No. Product Pack Sizes Purity Description ab120654 Betulinic acid Ç 10mg 50mg Anticancer agent. TGR5 agonist.

Receptors & Transporters: Toll-Like Receptors

Cat No. Product Pack Sizes Purity Description ab120827 Hydroxychloroquine sulfate Ç 5mg 25mg >99% Anti-inflammatory and anti-malarial agent. ab141410 Imiquimod Ç 100mg 500mg >95% Toll-like receptor 7 agonist; immunomodulator

Receptors & Transporters: Transporters

Cat No. Product Pack Sizes Purity Description ab120095 AM404 10mg 50mg >99% Anandamide transport inhibitor ab120346 N-Arachidonylglycine (NAGly) 5mg 25mg 100mg >98% T-type Ca2+ channel blocker. Endogenous GLYT2 inhibitor. Ç ab120574 Bromocriptine mesylate 100mg 500mg >99% Potent, selective D2-like dopamine receptor agonist ab120534 Bupropion hydrochloride Ç É 50mg 250mg 1g >98% Non-selective DAT/NET inhibitor ab120012 CGP 37157 10mg 50mg >99% Na+-Ca2+ exchange inhibitor Ç É ab120729 (±)-Chlorpheniramine maleate 100mg >99% Potent H1 antagonist and SNRI ab120133 Citalopram É 25mg 100mg >98% 5-HT reuptake inhibitor ab120300 Cyclopiazonic acid from Penicillium grisefulvum 10mg 50mg >99% Ca2+-ATPase inhibitor ab120066 Dihydrokainic acid É 1mg 10mg 50mg >99% EAAT2 inhibitor ab141205 Erythromycin Ç 1g 5g Macrolide antibiotic ab120500 Esomeprazole sodium É 50mg 250mg >99% H+/ K+-ATPase (proton pump) inhibitor ab120331 FFN511 fi 1mg 5mg >99% Fluorescent false neurotransmitter; highly efficient optical tracer of dopamine ab120077 Fluoxetine hydrochloride É 10mg 50mg >99% 5-HT reuptake inhibitor ab120314 Furosemide 1g 5g 10g >99% Inhibitor of the Na+/2Cl-/K+ cotransporter.

Also GABAA antagonist. ab120607 GBR 12909 dihydrochloride Ç É 10mg 50mg >99% Selective dopamine transport inhibitor ab141046 Imipramine hydrochloride Ç 5g >98% Tricyclic antidepressant ab120769 Maprotiline hydrochloride Ç É 100mg >99% Noradrenaline reuptake inhibitor ab120552 α-(Methylamino)isobutyric acid Ç É 250mg 1g >97% Glutamine transport inhibitor ab120755 Milnacipran hydrochloride Ç É 10mg 50mg >99% Serotonin and norepinephrine reuptake inhibitor Ç ab120587 Nefazodone hydrochloride 10mg 50mg >99% Potent 5-HT2A antagonist ab120312 Nipecotic acid É 100mg 1g 5g >98% GABA reuptake inhibitor ab141134 Nisoxetine hydrochloride Ç 10mg 50mg >99% Potent and selective norepinephrine reuptake (NET) inhibitor ab120317 NNC 05-2090 Ç 10mg 50mg >99% GABA uptake inhibitor ab120364 NNC 711 É 10mg 50mg >99% Potent, selective GAT-1 inhibitor ab120748 Ouabain octahydrate Ç É 100mg >98% Na+/K+ ATPase inhibitor ab120069 Paroxetine hydrochloride 10mg 50mg >99% 5-HT uptake inhibitor ab120157 Reboxetine mesylate É 10mg 50mg >99% Noradrenaline reuptake inhibitor ab120609 Reserpine Ç 250mg 1g >98% Irreversible vesicular monoamine transporter (VMAT2) antagonist ab120272 Riluzole (PK 26124) É 10mg 50mg >99% Neuroprotective agent. Modulates glutamate transmission. ab141068 Sertraline hydrochloride Ç 10mg 50mg >99% Selective serotonin reuptake inhibitor ab120529 Sibutramine hydrochloride Ë 10mg 50mg >98% Serotonin, noradrenaline & dopamine re-uptake inhibitor ab120326 SKF89976A hydrochloride É 10mg 50mg >99% Highly selective GAT-1 inhibitor ab120276 tBuBHQ (BHQ) 100mg 500mg >99% Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor ab120286 Thapsigargin 1mg >98% Ca2+-ATPase inhibitor ab120237 Tiagabine hydrochloride É 10mg 50mg >99% Selective GAT-1 inhibitor ab120758 (R)-Tomoxetine hydrochloride Ç É 10mg 50mg >99% Potent, selective norepinephrine reuptake inhibitor ab120309 UCPH-101 fi 1mg 10mg >98% Potent, selective EAAT1 inhibitor ab120715 Venlafaxine hydrochloride Ç É 10mg 50mg >99% Serotonin-norepinephrine reuptake inhibitor

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Ion Channels: Calcium

Cat No. Product Pack Sizes Purity Description ab120210 ω-Agatoxin IVA É 10μg 100μg >95% Ca2+ channel blocker (P and Q type) ab120346 N-Arachidonylglycine (NAGly) 5mg 25mg 100mg >98% T-type Ca2+ channel blocker. Endogenous GLYT2 inhibitor. ab120366 (±)-BAYK8644 Ç 10mg 50mg >99% Potent L-type Ca2+ channel activator ab141038 Cilnidipine Ç 10mg 50mg >98% Dual L- and N-type Ca2+ channel blocker ab120215 ω-Conotoxin GVIA É Ë 500μg 1mg >96% Ca2+ channel blocker (N type) ab120211 ω-Conotoxin MVIIC É Ë 100μg 500μg >95% Ca2+ channel blocker (P and Q-type) ab120333 D890 É 10mg 50mg >99% Intracellular Ca2+ channel blocker ab120260 Diltiazem É 1g >99% L-type Ca2+ channel antagonist ab120219 Gabapentin É 10mg 50mg >99% α2δ ligand ab120142 Isradipine 10mg 50mg >98% L-type Ca2+ channel blocker ab120531 Nicardipine hydrochloride Ç 1g 5g >99% L-type Ca2+ channel antagonist ab120135 Nifedipine 250mg 1g >99% L-type Ca2+ channel blocker ab120138 Nimodipine 100mg 500mg >98% L-type Ca2+ channel blocker ab120139 Nitrendipine 100mg 500mg >98% L-type Ca2+ channel blocker É 2+ ab120259 SNX 482 10μg 100μg >96% R-Type Ca (Cav2.3) channel blocker ab120140 Verapamil hydrochloride É 1g >99% L-type Ca2+ channel blocker ab120369 Zonisamide 10mg 50mg >99% Non-selective Na+ / Ca2+channel blocker

Ion Channels: Chloride

Cat No. Product Pack Sizes Purity Description ab120258 1-EBIO 10mg 50mg >99% Activator of Ca2+-activated K+ channels and CFTR channels

Ion Channels: Cyclic nucleotide-gated

Cat No. Product Pack Sizes Purity Description ab120532 L-cis-Diltiazem É 5mg 25mg >98% Selective cyclic nucleotide-gated channel blocker

Ion Channels: Ionophores, indicators & chelators

Cat No. Product Pack Sizes Purity Description ab120503 BAPTA-AM Ç 25mg >98% Selective Ca2+ chelator. Analogue of BAPTA. ab120449 BAPTA sodium salt Ç É 250mg 1g 5g >98% Selective Ca2+ chelator ab120873 Fura-2 AM (Fura-2 acetoxymethyl ester) Ç 1mg >95% Selective Ca2+ chelator; fluorescent indicator ab120370 Ionomycin (free acid) 1mg 5mg >99% Ca2+ ionophore ab120116 Ionomycin Ca2+ Salt 1mg 5mg >99% Ca2+ ionophore ab120499 Monensin sodium salt Ç 100mg 1g >95% Na+ ionophore ab120494 Nigericin Na+ salt Ç 10mg 50mg >98% K+ ionophore ab141063 Taurine Ç 1g >98% Partial glycine receptor agonist ab120852 Valinomycin from Streptomyces fulvissimus Ç 10mg 50mg >98% K+ selective ionophore

Ion Channels: Other

Cat No. Product Pack Sizes Purity Description ab120102 ZD7288 É 10mg 50mg >98% Sino-atrial node function modulator

Ion Channels: Potassium

Cat No. Product Pack Sizes Purity Description ab120122 4-Aminopyridine (4-AP) É 100mg >99% K+ channel blocker ab120268 Apamin 500μg >95% Blocker of small conductance Ca2+-activated K+ channels ab120503 BAPTA-AM Ç 25mg >98% Selective Ca2+ chelator. Analogue of BAPTA. ab120616 2,3-Butanedione 2-monoxime (BDM) Ç 500mg Non-selective myosin ATPase inhibitor ab120269 Charybdotoxin É 10μg 100μg >98% K+ channel blocker Ç ab120548 Cisapride 10mg 50mg >99% 5-HT4 receptor agonist. hERG blocker. Ç ab120486 Cromakalim 10mg 50mg >99% KIR6.x (KATP) channel activator ab120829 CyPPA Ç 10mg 50mg >98% First selective SK channel activator + ab120266 Diazoxide 100mg >99% Selective KIR6.x (ATP-sensitive K channel) activator ab120158 E-4031 dihydrochloride É 10mg 50mg >99% HERG K+ channel blocker ab120258 1-EBIO 10mg 50mg >99% Activator of Ca2+-activated K+ channels and CFTR channels ab120267 Glibenclamide (Glyburide) 100mg >99% K+ channel blocker

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Ion Channels: Potassium

Cat No. Product Pack Sizes Purity Description

ab120502 GW542573X 10mg 50mg >99% Novel, selective KCa2 channel activator ab120379 Iberiotoxin 100μg >95% Selective blocker of the high-conductance, Ca2+-activated K+ channel Ç ab120485 Levcromakalim 10mg 50mg >99% KATP channel activator. ab120371 NS309 10mg 50mg >98% Activates Ca2+-activated K+ channels ab120410 RuBi-4AP fi 10mg Caged K+ channel blocker, uncaged by visible light ab120656 Tamoxifen citrate Ç 100mg 1g >99% Estrogen receptor antagonist and partial agonist + ab120270 Terfenadine 100mg >98% K channel blocker. H1 antagonist. Ç É fi ab120484 Tertiapin LQ 1mg >95% Potent, selective blocker of Kir1.1 channels. Tertiapin Q (ab120432) derivative. ab120432 Tertiapin Q É fi 1mg >99% Potent inward rectifier K+ channel blocker ab120275 Tetraethylammonium chloride (TEA) É 5g 25g 100g Non-selective K+ channel blocker ab120278 Tolbutamide 100mg >99% K+ channel blocker ab120852 Valinomycin from Streptomyces fulvissimus Ç 10mg 50mg >98% K+ selective ionophore ab120089 XE-991 dihydrochloride É 10mg 50mg >99% Potent, selective KCNQ channel blocker; blocks M current

Ion Channels: Sodium

Cat No. Product Pack Sizes Purity Description

ab120282 A 803467 10mg 50mg >98% Selective NaV1.8 channel blocker ab120281 Amiloride hydrochloride É 100mg >99% eNaC blocker ab120504 Flecainide 10mg 50mg >99% Sodium channel blocker ab120119 N-Methyllidocaine iodide (QX-372 iodide) É 10mg 50mg >99% Anti-arrthymic ab120955 Procainamide hydrochloride Ç 10g 25g >99% Sodium channel blocker. Specific DNA methyltransferase 1 inhibitor. ab120865 Procaine hydrochloride Ç 250mg >99% Na+ channel blocker. DNA methylation inhibitor. ab120483 Psalmotoxin-1 É 20μg 100μg >95% Potent, selective ASIC1a blocker ab120126 QX-222 É 10mg 50mg >99% Na+ channel blocker ab120117 QX-314 bromide (N-Ethyllidocaine bromide) É 50mg 100mg >99% Na+ channel blocker ab120118 QX-314 chloride (N-Ethyllidocaine chloride) É 50mg >99% Na+ channel blocker ab120054 Tetrodotoxin Ë 1mg >98% Na+ channel blocker ab120055 Tetrodotoxin citrate É Ë 1mg >98% Na+ channel blocker; water-soluble ab120279 Veratridine 10mg 50mg >97% Na+ channel opener ab120369 Zonisamide 10mg 50mg >99% Non-selective Na+ / Ca2+channel blocker

Ion Channels: TRP

Cat No. Product Pack Sizes Purity Description ab120340 5’-Iodoresiniferatoxin Ç 1mg >98% Selective TRPV1 antagonist. Some partial agonist activity reported. ab120281 Amiloride hydrochloride É 100mg >99% eNaC blocker Ç ab120917 Arvanil 10mg 50mg >98% Potent CB1 and TRPV1 agonist ab120025 Capsazepine 10mg 50mg >99% VR1 antagonist ab120554 HC-030031 Ç 10mg 50mg >99% TRPA1 blocker, orally active ab120284 KB-R7943 10mg 50mg >99% NCX inhibitor. TRPC blocker.

ab120099 NADA (N-Arachidonyldopamine) 5mg 25mg >98% Endogenous CB1 / TRPV1 agonist ab120878 4-Oxo-2-nonenal (4-ONE) Ç 1mg 5mg >98% Lipid peroxidation product. TRPA1 activator. ab120339 Resiniferatoxin 1mg >98% Ultrapotent TRPV1 agonist ab120280 SKF 96365 É 10mg 50mg >99% Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry.

Enzymes: ATPase & GTPase

Cat No. Product Pack Sizes Purity Description ab120497 Bafilomycin A1 10μg 100μg >98% Highly potent, selective (V)-ATPase inhibitor ab120616 2,3-Butanedione 2-monoxime (BDM) Ç 500mg Non-selective myosin ATPase inhibitor ab120300 Cyclopiazonic acid from Penicillium grisefulvum 10mg 50mg >99% Ca2+-ATPase inhibitor ab120474 Dynamin Inhibitors: Dynole™ Series Kit fi 1kit Dynamin inhibitor kit from the Dynole™ series ab120473 Dynamin Inhibitors: MiTMAB™ Series Kit fi 1kit Dynamin inhibitor kit from the MiTMAB™ series ab120475 Dynamin Inhibitors: Iminodyn™ Series Kit fi 1kit Dynamin inhibitor kit from the Iminodyn™ series ab120468 Dynamin Inhibitors Toolbox fi 1kit Dynamin inhibitor kit from the MiTMAB™, Dynole™ and Iminodyn™ chemical series. ab120192 Dynasore 10mg 50mg >99% Cell permeable dynamin inhibitor

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Enzymes: ATPase & GTPase

Cat No. Product Pack Sizes Purity Description ab120689 Dyngo-4a™ Ç fi 5mg Novel, highly potent dynamin inhibitor. Dynasore (ab120192) analog. ab120464 Dynole-31-2™ fi 5mg >98% Negative control for Dynole 34-2™ ab120463 Dynole-34-2™ fi 5mg >98% Potent dynamin I and dynamin II inhibitor ab120500 Esomeprazole sodium É 50mg 250mg >99% H+/ K+-ATPase (proton pump) inhibitor ab120462 Iminodyn-17™ fi 5mg >98% Negative control for Iminodyn-22™ ab120461 Iminodyn-22™ fi 5mg >98% Potent, broad spectrum dynamin inhibitor ab120466 MiTMAB™ É fi 5mg Cell permeable dynamin I and dynamin II inhibitor ab120494 Nigericin Na+ salt Ç 10mg 50mg >98% K+ ionophore ab120467 OcTMAB™ fi 5mg >98% Cell permeable dynamin I and dynamin II inhibitor ab120476 Pro-Myristic Acid fi 5mg Negative control for MiTMAB™ and OcTMAB™ ab141408 QS11 Ç 5mg >98% ARFGAP1 inhibitor. Wnt/β-catenin pathway modulator. ab120796 Rhodadyn B10™ Ç fi 5mg >95% Negative control for Rhodadyn C10™ ab120795 Rhodadyn C10™ Ç fi 5mg >95% Highly potent cell permeable dynamin I inhibitor ab120465 RTIL-13™ fi 5mg >98% Potent dynamin I and II inhibitor ab120386 Sodium orthovanadate (for Decavanadate solution) É 1g 5g Broad spectrum inhibitor of tyrosine phosphatases ab120286 Thapsigargin 1mg >98% Ca2+-ATPase inhibitor

Enzymes: Caspase

Cat No. Product Pack Sizes Purity Description ab141384 FMK negative control Ç 20μl >95% Negative control for caspase inhibitors ab141389 QVD-OPh Negative Control Ç 1mg 5mg >95% Q-VD-OPh negative control ab141383 Z-ATAD-FMK Ç 1mg 5mg >95% Caspase 12 inhibitor ab120488 Z-D(OMe)E(OMe)VD(OMe)-FMK 1mg 5mg >90% Cell permeable caspase-3 inhibitor ab141382 Z-IETD-FMK Ç 1mg 5mg >99% Caspase 8 inhibitor ab120489 Z-LE(OMe)VD(OMe)-FMK 1mg 5mg >90% Cell permeable derivative of caspase-4 inhibitor Z-LEVD-FMK ab120487 Z-VAD(OMe)-FMK 1mg 5mg >90% Cell permeable, irreversible pan-caspase inhibitor ab120382 Z-VAD-FMK 1mg 5mg >98% Irreversible general caspase inhibitor ab141388 Z-YVAD-FMK Ç 1mg 5mg >98% Irreversible caspase 1 inhibitor

Enzymes: Cholinesterase

Cat No. Product Pack Sizes Purity Description ab120763 Donepezil hydrochloride Ç É 10mg 50mg >99% Acetylcholinesterase inhibitor ab141114 Galanthamine hydrobromide Ç 100mg >99% Alkaloid acetylcholinesterase inhibitor

Enzymes: Coenzymes

Cat No. Product Pack Sizes Purity Description É ab120403 β-Nicotinamide adenine dinucleotide (β-NAD) 25mg 250mg 1g >96% Coenzyme and enzyme substrate. P2Y11 agonist.

Enzymes: Cyclase

Cat No. Product Pack Sizes Purity Description ab120058 Forskolin 10mg 50mg 100mg >98% Adenylyl cyclase activator ab120190 NKH 477 (Colforsin daropate) É 10mg 50mg >98% Water-soluble analogue of forskolin (ab120058), an adenylyl cyclase activator ab120022 ODQ 10mg 50mg >99% Selective, potent inhibitor of NO-sensitive guanylyl cyclase ab120915 YC-1 Ç 10mg 50mg >99% Reversible soluble guanylyl cyclase activator

Enzymes: Cyclooxygenase

Cat No. Product Pack Sizes Purity Description ab120990 Acetaminophen Ç 100mg >98% Selective COX-3 inhibitor ab120621 Diclofenac Sodium Salt Ç 1g >99% Potent cyclo-oxygenase inhibitor ab120716 (-)-Epigallocatechin Gallate Ç É 1mg 50mg >98% Potent anti-oxidant flavonoid ab141086 Etodolac Ç 10mg 50mg >99% COX-2 inhibitor; NSAID ab141015 (S)-(+)-Ibuprofen Ç 100mg >99% Non-selective COX inhibitor ab120719 Indomethacin Ç 100mg >99% Non-selective COX inhibitor

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Enzymes: Cyclooxygenase

Cat No. Product Pack Sizes Purity Description ab141035 (S)-Ketoprofen Ç 1g >98% Highly potent COX1/2 inhibitor. Non-steroidal anti-inflammatory drug (NSAID). ab120662 Luteolin Ç 10mg 50mg >99% Antioxidant, anti-inflammatory, anti-cancer flavonoid ab141033 Naproxen sodium Ç 50mg >99% Non-selective COX inhibitor ab120295 NS 398 10mg 50mg >98% COX-2 inhibitor ab141110 Piroxicam Ç 100mg >99% Reversible, selective cyclooxygenase-1 (COX-1) inhibitor ab120649 SC-560 Ç 100mg >99% Highly selective COX-1 inhibitor ab120746 Sodium salicylate Ç É 5g >99% Cell permeable anti-inflammatory agent ab120650 Sulindac sulfide Ç 5mg 25mg >98% Active metabolite of Sulindac. COX-1/ 2 inhibitor.

Enzymes: Cytochrome P450

Cat No. Product Pack Sizes Purity Description ab120744 Clotrimazole Ç 50mg >99% Non-selective P450 cytochrome inhibitor ab141205 Erythromycin Ç 1g 5g Macrolide antibiotic ab141084 Exemestane Ç 10mg 50mg >99% Irreversible, orally active, steroidal aromatase (CYP19) inhibitor ab141065 Fluconazole Ç 50mg >99% Triazole antifungal agent. Cytochrome P450 inhibitor. ab120816 Itraconazole Ç 50mg 100mg >99% Cytochrome p450 inhibitor ab120620 Ketoconazole Ç 100mg >99% Potent cytochrome P450 inhibitor. Anti-fungal agent. ab120721 Myricetin Ç 5mg 25mg >97% Potent anti-neoplastic, anti-oxidant and anti-inflammatory agent

Enzymes: Deacetylase

Cat No. Product Pack Sizes Purity Description ab120860 (+)-Abscisic acid Ç 1mg >99% Phytohormone; produced by a variety of cells in humans and animals ab120862 Caffeic acid Ç 250mg 1g >98% Specific NF-κB inhibitor ab141181 Cambinol Ç 5mg 25mg >98% SIRT1/2 inhibitor ab141401 M344 Ç 1mg >98% Novel and selective HDAC6 inhibitor Ç ab120864 Nicotinamide 100mg 1g >99% Amide form of vitamin B3 ab120883 Scriptaid Ç 10mg 25mg >98% HDAC inhibitor ab141253 Sodium 4-phenylbutyrate Ç 100mg >99% Histone deacetylase inhibitor ab120948 Sodium butyrate Ç 50mg 250mg 1g >98% Histone deacetylase inhibitor ab141120 Splitomicin Ç 10mg 50mg >98% Sir2P inhibitor ab141415 Tubastatin A Ç 1mg 5mg >98% Potent, selective HDAC6 inhibitor ab120745 Valproic acid, sodium salt Ç É 100mg Histone deacetylase inhibitor

Enzymes: Dehydrogenase

Cat No. Product Pack Sizes Purity Description ab120819 JK 184 Ç 10mg 50mg >99% Potent Hedgehog signaling inhibitor ab120923 Leelamine Ç 10mg 50mg >98% Pyruvate dehydrogenase kinase (PDK) inhibitor ab120664 Mycophenolic Acid Ç 100mg >99% Immunosuppressant. Inosine monophosphate dehydrogenase inhibitor.

Enzymes: Demethylase

Cat No. Product Pack Sizes Purity Description ab120973 Chlorogenic acid hemihydrate Ç 250mg 1g >99% Antioxidant with a variety of biological effects ab120606 Tranylcypromine hydrochloride (2-PCPA) Ç 50mg >98% Irreversible monoamine oxidase (MAO) inhibitor

Enzymes: Hydrolase

Cat No. Product Pack Sizes Purity Description ab120999 JNJ 1661010 Ç 10mg 50mg >99% Potent, selective and reversible fatty acid amide hydrolase inhibitor ab120894 PF-3845 Ç 10mg 25mg >98% Selective, irreversible FAAH inhibitor ab120668 URB 597 Ç 5mg 25mg >98% Potent and selective FAAH inhibitor

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Enzymes: Isomerase

Cat No. Product Pack Sizes Purity Description ab120115 Camptothecin 50mg 250mg >98% DNA topoisomerase inhibitor ab141107 CPT 11 (Irinotecan) Ç 10mg 50mg >99% Potent DNA topoisomerase I inhibitor ab120629 Doxorubicin hydrochloride Ç É 10mg 50mg >98% Topoisomerase II inhibitor. Antibiotic with cytotoxic actions. ab120227 Etoposide 25mg 100mg >98% Topoisomerase II inhibitor ab120922 HU-331 Ç 5mg 25mg >95% Potent cannabinoid quinone. Topoisomerase II inhibitor. ab141071 10-Hydroxycamptothecin Ç 10mg 50mg >99% DNA topoisomerase I inhibitor ab141097 β-Lapachone Ç 10mg 50mg >98% Topoisomerase I inhibitor ab141041 Mitoxantrone dihydrochloride Ç 50mg >98% Type II topoisomerase inhibitor ab141108 SN 38 Ç 10mg 50mg >99% DNA topoisomerase I inhibitor. Active metabolite of CPT-11. ab120388 Topotecan hydrochloride (SK&F 104864) 10mg 50mg >98% Topoisomerase inhibitor

Enzymes: Kinase

Cat No. Product Pack Sizes Purity Description ab120335 A 769662 fi 10mg 50mg >99% AMP-activated protein kinase activator ab120901 ABT-869 (Linifanib) Ç 5mg 10mg >98% Potent VEGF and PDGF receptor tyrosine kinase inhibitor ab120493 Adenosine 3′,5′-cyclic monophosphate (cAMP) É 1g 5g 25g >98% Second messenger. PKA activator. ab141170 AG 1296 Ç fi 5mg 25mg >99% Potent specific PDGF receptor tyrosine kinase inhibitor ab120950 AG 490 Ç 10mg 50mg >99% JAK2/3 inhibitor ab141059 AG-879 Ç 10mg >99% Selective TrkA receptor inhibitor ab120358 AICAR (Acadesine/AICA riboside) É 50mg 250mg >98% Cell-permeable activator of AMP-activated protein kinase ab141337 Akt-I-12 Ç 1mg 5mg >95% Selective, reversible Akt inhibitor ab141070 Alsterpaullone Ç 1mg >99% Potent cyclin-dependent kinase (CDK) and GSK-3β inhibitor ab141338 AMG-25 Ç 1mg 5mg >95% Potent c-Kit inhibitor ab141339 AMG-Tie2-1 Ç 1mg 5mg >95% Highly potent, non-selective TIE2 (TEK) inhibitor ab120495 Anisomycin 10mg 50mg >98% Protein synthesis inhibitor ab141340 AP24534 Ç 10mg 50mg >95% Multitarget tyrosine kinase inhibitor. Potent BCR-ABL inhibitor. ab120898 AS-041164 Ç 5mg 25mg >98% Potent and selective PI3Kγ inhibitor ab120929 AS-252424 Ç 5mg 10mg >95% Potent and selective PI3Kγ inhibitor ab120935 AS-604850 Ç 5mg 25mg >98% Selective, ATP-competitive PI3Kγ inhibitor ab120928 AS-605240 Ç 10mg 50mg >98% Potent and selective PI3Kγ inhibitor ab141341 AT9283 Ç 10mg 50mg >95% Potent Aurora A and B kinase inhibitor ab141342 AZ-960 Ç 1mg 5mg >95% Novel, potent and selective JAK2 inhibitor ab141343 AZD6244 Ç 10mg 50mg >95% Novel, potent and selective MEK1/2 inhibitor ab141344 AZD7762 Ç 10mg 50mg >95% Novel checkpoint kinase inhibitor ab141371 Baricitinib Phosphate Ç 1mg 5mg >95% JAK1/2 inhibitor ab141345 Bayer-18 Ç 1mg 5mg >95% Potent and selective TYK2 inhibitor ab141335 (R)-BI-2536 Ç 10mg 50mg >95% Potent PLK1 inhibitor ab120640 BI-D1870 Ç 10mg 50mg >98% Ribosomal S6 kinase (RSK) inhibitor ab120891 BIO Ç 10mg 25mg >98% Potent, selective, reversible GSK3 inhibitor; cell-permeable ab141346 BMS-3 Ç 1mg 5mg >95% Potent LIM kinase inhibitor ab141347 BMS-5 Ç 1mg 5mg >95% Potent LIM kinase inhibitor ab141402 Canertinib (CI-1033) Ç 5mg 50mg >99% Potent irreversible EGFR and HER2/ErbB2 tyrosine kinase inhibitor ab120930 CAY10505 Ç 10mg 50mg >98% Potent PI3Kγ and casein kinase 2 inhibitor ab120944 CAY10577 Ç 10mg 50mg >95% CK2 inhibitor ab120945 CAY10578 Ç 5mg 25mg >95% Selective, ATP competitive CK2 inhibitor ab120903 CAY10626 Ç 1mg 5mg >98% Potent PI3Kα/mTOR inhibitor ab120655 Celastrol from Celastrus scandens Ç 10mg 50mg >99% Anti-inflammatory and anti-proliferative agent ab141378 CEP-33779 Ç 1mg 5mg >95% Selective JAK2 inhibitor ab120365 CGP 57380 1mg 10mg 50mg >98% MNK inhibitor ab120890 CHIR99021 Ç 1mg 5mg >98% Potent, highly selective GSK3 inhibitor ab120424 8-(4-Chlorophenylthio)adenosine 3’,5’-cyclic monophosphate (8-CPT-cAMP) É 20mg 100mg >98% Cell permeable cAMP analogue, protein kinase modulator ab141348 CI-1040 Ç 10mg 50mg >95% ATP non-competitive MEK1/2 inhibitor ab141349 CP-724714 Ç 10mg 50mg >95% Potent, selective HER2/ErbB2 tyrosine kinase inhibitor

Refer to page 3 for symbol key 26 Discover more at www.abcam.com/biochemicals Catalog Update01 - International_Update 31/01/2013 08:18 Page 27

Enzymes: Kinase

Cat No. Product Pack Sizes Purity Description ab120964 Crosstide Ç 1mg >98% Akt peptide substrate ab120965 Crosstide (biotinylated) Ç 1mg >98% Akt peptide substrate, biotinylated ab141350 CX-4945 (Silmitasertib) Ç 1mg 5mg >95% Potent, selective ATP-competitive casein kinase 2 inhibitor ab141351 CYC-116 Ç 10mg 50mg >95% Potent Aurora kinase A/B and VEGFR inhibitor ab120220 D4476 10mg 50mg >99% CK1 inhibitor ab120941 (-)-Deguelin Ç 10mg 50mg >98% Akt inhibitor. Anti-cancer agent. ab120996 7,8-Dihydroxyflavone (7,8-DHF) Ç 10mg 50mg >99% Selective TrkB receptor agonist. Flavonoid. ab120843 Dorsomorphin Ç 10mg 50mg >99% Potent, selective and reversible AMP-kinase inhibitor. Selective for BMP signaling. ab120939 DRB (Benzimidazole) Ç 10mg 50mg >98% Casein kinase II inhibitor ab120622 Ellagic acid Ç 50mg >99% Selective, casein kinase 2 (CK2) inhibitor ab120716 (-)-Epigallocatechin Gallate Ç É 1mg 50mg >98% Potent anti-oxidant flavonoid ab120881 Erlotinib (CP-358,774) Ç 250mg 1g >98% Potent, selective and reversible EGFR tyrosine kinase inhibitor ab141352 GDC-0941 Ç 10mg 50mg >95% Potent, non-selective PI3K inhibitor ab120112 Genistein 10mg 50mg 100mg >99% Protein tyrosine kinase inhibitor. Anticancer agent. ab141395 Genistin Ç 10mg >99% Isoflavone glycoside; inactive analog of Genistein Ç ab141413 Go 6976 500μg >99% Potent PKC inhibitor. Selective for PKCα and β. ab141379 GPLG0634 Ç 1mg 5mg >95% JAK1/2 inhibitor ab141353 GSK-25 Ç 1mg 5mg >95% ROCK inhibitor ab120341 H89 dihydrochloride 1mg 10mg 50mg >98% Kinase inhibitor ab120306 HA-1077 (Fasudil) É 10mg 50mg >98% ROCK2 inhibitor ab120225 Harmine 100mg >98% Potent and selective inhibitor of DYRK1A ab120863 Hydralazine hydrochloride Ç 1g >99% DNA methylation inhibitor. Anti-hypertensive agent ab141355 IC87114 Ç 10mg 50mg >95% Selective PI3Kδ inhibitor. Cell-permeable. ab141356 INCB018424 (Ruxolitinib) Ç 10mg 50mg >95% Potent, selective JAK1 and JAK2 inhibitor ab120960 Indirubin Ç 5mg 25mg >98% Potent cyclin-dependent kinase and GSK-3β inhibitor ab120452 Iodotubercidin 1mg 5mg >95% Potent, adenosine kinase inhibitor ab141014 IPA 3 Ç 10mg 50mg >97% Group I, p21-activated kinase (PAK) inhibitor ab141168 Isobavachalcone Ç 1mg >99% Akt inhibitor. Natural chalcone. ab120710 Isoprenaline hydrochloride Ç É 100mg >99% Non selective β-adrenoceptor agonist ab120419 K252a 200μg 1mg >99% Highly potent inhibitor of protein and CAM kinases ab120937 Kenpaullone Ç 5mg 10mg >98% CDK2, GSK3β and LCK inhibitor ab141357 Ki20227 Ç 10mg 50mg >95% Highly selective c-Fms tyrosine kinase inhibitor

ab120421 KN-62 1mg 5mg >98% CaM kinase II inhibitor. P2X7 antagonist. ab120980 KN-93 (water soluble) Ç 1mg >99% Potent, specific CaMK II inhibitor ab120423 KT5823 100μg >95% Potent, selective inhibitor of PKG ab120637 KU-55933 Ç fi 10mg >99% Potent, selective, competitive ATM kinase inhibitor ab120966 L803 Ç 1mg >99% Phosphopeptide GSK-3 inhibitor ab120853 Lithium chloride Ç 1g 5g >99% GSK-3β inhibitor ab120662 Luteolin Ç 10mg 50mg >99% Antioxidant, anti-inflammatory, anti-cancer flavonoid ab120243 LY 294002 5mg 25mg >99% PI3-kinase inhibitor ab120956 LY 303511 dihydrochloride Ç 5mg >98% Negative control for LY 294002 (ab120243) ab141358 Merck 5 Ç 1mg 5mg >95% Potent, reversible ATP-competitive JAK inhibitor ab120847 Metformin hydrochloride Ç 100mg >99% AMPK activator ab120653 2-Methoxyestradiol Ç 10mg 50mg >98% Potent antitumor and antiangiogenic agent ab141372 Momelotinib Ç 10mg 50mg >95% Selective JAK2 inhibitor ab120721 Myricetin Ç 5mg 25mg >97% Potent anti-neoplastic, anti-oxidant and anti-inflammatory agent ab120951 Nifuroxazide Ç 100mg >98% JAK/STAT signaling inhibitor. Nitrofuran antibiotic. ab120943 NSC 210902 Ç 10mg 50mg >95% Selective, ATP competitive CK2 inhibitor ab120970 NU 7026 Ç 10mg 50mg >99% Novel, specific, reversible DNA-PK inhibitor ab120882 NVP-BEZ235 Ç 25mg 100mg >98% Potent ATP-competitive PI3K and mTOR inhibitor ab141373 NVP-BSK805 Ç 10mg 50mg >95% Selective JAK2 inhibitor ab120938 Olomoucine Ç 5mg 25mg >98% ATP-competitive CDK inhibitor ab141122 (±)-Palmitoylcarnitine chloride Ç 100mg >98% Protein kinase C (PKC) inhibitor. Intermediate in lipid metabolism. ab120639 PD 0325901 Ç 10mg 50mg >99% Potent MEK 1 and 2 inhibitor ab141117 PD 173074 Ç 10mg 50mg >99% Potent FGFR1 and FGFR3 inhibitor ab120234 PD 98059 1mg 10mg 50mg >99% MEK1 inhibitor ab141171 Pelitinib (EKB-569) Ç 5mg 25mg >98% Irreversible EGFR inhibitor ab141359 PF431396 Ç 1mg 5mg >95% Potent dual FAK/Pyk2 inhibitor ab141360 PF-562271 Ç 1mg 5mg >95% Potent, reversible, ATP-competitive FAK/Pyk2 inhibitor

Discover more at www.abcam.com/biochemicals 27 Catalog Update01 - International_Update 31/01/2013 08:18 Page 28

Enzymes: Kinase

Cat No. Product Pack Sizes Purity Description ab120985 PF 670462 Ç 10mg 50mg >99% Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor ab120297 Phorbol 12-myristate 13-acetate (PMA) 1mg 5mg 25mg >99% PKC activator ab120079 Phospho-Glycogen Synthase Peptide-2 É 500μg 1mg >99% GSK substrate ab141361 PI 103 Ç 10mg 50mg >95% Novel, potent, ATP-competitive PI3K, mTOR and DNA-PK inhibitor ab120722 Piceatannol Ç 10mg 50mg >99% Syk tyrosine kinase inhibitor ab120931 PIK-75 Ç 5mg 25mg >98% Selective p110α PI3K inhibitor ab141362 PLX4720 Ç 10mg 50mg >95% Potent, selective mutant B-RafV600E and c-Raf-1Y340D/Y341D inhibitor ab120859 PP 1 Ç 10mg >98% Potent Src family tyrosine kinase inhibitor ab120308 PP2 1mg 5mg 10mg >98% Src and RIP2 kinase inhibitor ab141405 PP242 Ç 1mg >98% Potent and selective mTOR inhibitor ab120617 PP3 Ç 10mg 100mg >98% Negative control for the Src kinase inhibitor PP2. ab120880 Prostratin Ç 500μg 1mg >98% PKC activator; reactivates HIV-1 latency ab120304 Purvalanol A 1mg 10mg 50mg >98% Potent CDK inhibitor ab120305 Purvalanol B 10mg 50mg >98% CDK2 inhibitor ab141363 R406 Ç 1mg 5mg >95% Selective Syk kinase inhibitor ab141364 R428 Ç 1mg 5mg >95% Selective Axl kinase inhibitor ab141365 R788 Ç 10mg 50mg >95% Selective Syk inhibitor ab120374 Ro 31-8220 mesylate (Bisindolylmaleimide IX) 1mg 10mg 50mg >98% Protein kinase inhibitor ab120377 Rottlerin 10mg 50mg >95% Kinase inhibitor ab141366 S-99 Ç 1mg 5mg >95% ASK inhibitor ab120182 SAMS peptide É 1mg 5mg >95% AMP-activated protein kinase substrate ab120638 SB 202190 Ç 10mg 50mg >99% Highly selective, potent, cell permeable p38 MAP kinase inhibitor ab120162 SB 203580 1mg 10mg 50mg >99% p38 MAP kinase inhibitor ab120235 SB 203580 hydrochloride É 10mg >99% p38 MAP kinase inhibitor; water soluble ab120202 SB 216763 1mg 10mg 50mg >98% Potent selective GSK-3 inhibitor ab120163 SB431542 1mg 5mg 10mg >99% ALK inhibitor ab120802 SC-66 Ç 10mg 50mg >99% Allosteric Akt inhibitor ab120836 SD 169 Ç 10mg 50mg >99% Potent, selective and ATP competitive p38α MAPK inhibitor ab120082 SL 327 1mg 10mg 25mg >99% MEK inhibitor ab141367 SMI-4a Ç 10mg 50mg >95% Selective Pim kinase inhibitor ab120746 Sodium salicylate Ç É 5g >99% Cell permeable anti-inflammatory agent ab120065 SP600125 10mg 50mg >98% JNK inhibitor ab120839 Src Kinase Inhibitor I (SKI-1) Ç 10mg 50mg >98% Potent, selective and dual site Src tyrosine kinase family inhibitor ab120056 Staurosporine 100μg 500μg >98% Protein kinase inhibitor ab141368 SU-5402 Ç 1mg 5mg >95% Potent FGFR and VEGFR inhibitor ab120650 Sulindac sulfide Ç 5mg 25mg >98% Active metabolite of Sulindac. COX-1/ 2 inhibitor. ab120989 TAK 715 Ç 10mg 50mg >99% Potent p38 MAPK inhibitor ab120988 TBB Ç 10mg 50mg >98% Selective, cell-permeable casein kinase-2 (CK2) inhibitor ab120835 TCS JNK 5a Ç 10mg 50mg >99% Selective JNK2/3 inhibitor ab141374 TG101209 Ç 10mg 50mg >95% Potent, selective JAK2 inhibitor. Flt3 and RET inhibitor. ab141377 TG-101348 Ç 10mg 50mg >95% Potent, selective JAK2 inhibitor ab141376 TG-46 Ç 1mg 5mg >95% JAK2 inhibitor ab141375 TG-89 Ç 1mg 5mg >95% JAK2 inhibitor ab120924 TGX-221 Ç 100μg 500μg >98% Potent, selective PI3K inhibitor ab120289 TMCB 10mg 50mg >98% Selective CK2 inhibitor ab120936 Triciribine Ç 1mg 5mg >98% Selective, potent inhibitor of Akt activation ab141172 Tyrphostin AG 957 Ç 1mg 5mg >99% Potent, selective p210 tyrosine kinase inhibitor ab120241 U0126 5mg 25mg >98% Selective MKK inhibitor ab141369 Vargatef Ç 10mg 50mg >95% Potent VEGFR, PDGFR and FGFR inhibitor ab120148 Wortmannin 1mg 5mg >98% PI3-kinase inhibitor ab120129 Y-27632 dihydrochloride É 1mg 10mg 50mg >99% Selective Rho kinase inhibitor ab141370 YM201636 Ç 1mg 5mg >95% Potent, selective PIKfyve inhibitor ab120993 ZIP Ç 1mg >97% Novel, cell-permeable protein kinase Mζ (PKMζ) inhibitor ab120428 ZM 336372 1mg 10mg 50mg >98% Potent, selective c-Raf inhibitor

Refer to page 3 for symbol key 28 Discover more at www.abcam.com/biochemicals Catalog Update01 - International_Update 31/01/2013 08:18 Page 29

Enzymes: Oxidases

Cat No. Product Pack Sizes Purity Description ab120615 Apocynin Ç 1g >99% Selective NADPH-oxidase inhibitor

ab120442 8-(3-Chlorostyryl)caffeine 10mg 50mg >98% Selective A2A receptor antagonist. MAO-B inhibitor. ab120604 (R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride) Ç É 250mg 1g >99% MAO-B selective inhibitor ab120605 Harmane Ç 100mg >99% β-Carboline. Imidazoline ligand. MAO inhibitor. ab120236 Rasagiline mesylate É 10mg 50mg >99% MAO-B inhibitor ab120606 Tranylcypromine hydrochloride (2-PCPA) Ç 50mg >98% Irreversible monoamine oxidase (MAO) inhibitor

Enzymes: Oxygenase

Cat No. Product Pack Sizes Purity Description ab120723 Baicalein Ç 50mg >98% Flavonoid. Lipoxygenase inhibitor. ab120618 Curcumin (Diferuloylmethane) Ç 50mg 250mg >85% Flavonoid. Lipooxygenase inhibitor. Anti-oxidant, anti-inflammatory agent. ab120645 Edaravone (MCI-186) Ç 50mg 250mg >99% Free radical scavenger with neuroprotective effects

Enzymes: Phosphatase

Cat No. Product Pack Sizes Purity Description ab141016 Ascomycin Ç 1mg >98% Calcineurin/PP2B inhibitor. Immunosuppressant and antifungal activity. ab120967 Cantharidin Ç 25mg 100mg >98% Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor ab120114 Cyclosporin A 25mg 100mg 500mg >99% PP2B inhibitor ab141019 Deltamethrin Ç 10mg 50mg >98% Potent protein phosphatase 2B inhibitor ab141217 Levamisole hydrochloride Ç 250mg >99% Alkaline phosphatase inhibitor. Selective agonist at nematode nAChRs. ab120375 Okadaic acid 25μg 100μg >98% PP1 and PP2A inhibitor ab120386 Sodium orthovanadate (for Decavanadate solution) É 1g 5g Broad spectrum inhibitor of tyrosine phosphatases

Enzymes: Phosphodiesterase

Cat No. Product Pack Sizes Purity Description ab120240 Caffeine É 1g 5g >99% PDE inhibitor. Adenosine antagonist ab120451 Dipyridamole 1g 5g 10g >99% Non selective phosphodiesterase (PDE) inhibitor ab120840 IMBX Ç 100mg >98% Non-specific cAMP and cGMP inhibitor ab120942 Papaverine Ç 250mg 1g >98% Potent PDE inhibitor ab120725 Pentoxifylline Ç É 1g 5g >99% Phosphodiesterase inhibitor. Cytokine inhibitor. ab120031 (R)-(-)-Rolipram 10mg 50mg >99% Selective PDE4 inhibitor ab120029 (R,S)-Rolipram 10mg 50mg >99% Selective PDE4 inhibitor ab120030 (S)-(+)-Rolipram 10mg 50mg >99% PDE4 inhibitor; less active enantiomer ab120940 Zaprinast Ç 10mg 50mg >98% Specific cGMP phosphodiesterase inhibitor

Enzymes: Phospholipase & Lipase

Cat No. Product Pack Sizes Purity Description ab120350 AACOCF3 (Arachidonyl trifluoromethyl ketone) 5mg 25mg >98% Phospholipase-A2 inhibitor Ç ab120749 Quinacrine dihydrochloride 100mg >98% Non-selective phospholipase A2 inhibitor ab120926 URB602 Ç 10mg 50mg >98% Selective inhibitor of monoglycerol lipase (MGL) ab120927 URB754 Ç 10mg 50mg >98% Monoacylglycerol lipase inhibitor

Enzymes: Polymerase

Cat No. Product Pack Sizes Purity Description ab120631 Acyclovir Ç 50mg 100mg >99% Inhibits viral DNA polymerase. Antiherpetic agent ab141069 3-Aminobenzamide (3-AB) Ç 100mg >99% PARP inhibitor ab120368 DR2313 (PARP Inhibitor XI) 1mg 10mg 50mg >99% Potent, brain-penetrant and water-soluble PARP inhibitor ab141048 Fludarabine (FAMP) Ç 10mg 50mg >98% DNA synthesis inhibitor. Prodrug converted to active metabolite F-ara-A. ab120981 PJ34 hydrochloride Ç 10mg 50mg >98% Potent, selective PARP-1 inhibitor ab120897 XAV939 Ç 10mg 25mg >98% Potent tankyrase inhibitor. Inhibitor of Wnt/β-catenin signaling.

Discover more at www.abcam.com/biochemicals 29 Catalog Update01 - International_Update 31/01/2013 08:18 Page 30

Enzymes: Protease

Cat No. Product Pack Sizes Purity Description ab141166 Benazepril hydrochloride Ç 50mg 250mg >99% Angiotensin-converting enzyme (ACE) inhibitor. Prodrug. ab141417 Bestatin Ç 25mg 100mg >99% Aminopeptidase inhibitor; immunomodulator ab120804 Calpeptin Ç 10mg 50mg >98% Potent, cell permeable calpain inhibitor ab120655 Celastrol from Celastrus scandens Ç 10mg 50mg >99% Anti-inflammatory and anti-proliferative agent ab141398 Cisplatin Ç 100mg 1g >98% Potent, broad spectrum antineoplastic agent ab141412 Clasto lactacystin β lactone Ç 100μg >95% Cell-permeable and irreversible proteasome inhibitor ab141418 E-64 Ç 5mg 25mg >99% Potent cysteine protease inhibitor ab141167 Gabexate mesylate Ç 10mg 50mg >99% General serine protease inhibitor ab141411 Lactacystin Ç 200μg >95% Cell-permeable, potent and selective proteasome inhibitor ab141404 Leupeptin hemisulfate Ç 25mg 100mg >90% Reversible serine/cysteine protease inhibitor ab120661 Minocycline hydrochloride Ç É 50mg >99% Antibiotic. Demonstrates multiple effects. ab141416 Pepstatin A Ç 25mg 100mg >90% Potent selective aspartic protease inhibitor ab141196 1,10-Phenanthroline Ç 5g 25g >99% Membrane permeable chelating agent. Metalloprotease inhibitor. ab141032 PMSF Ç 50mg 250mg >99% Non-specific protease inhibitor ab141385 Z-LLY-FMK Ç 20μl >95% Irreversible calpain inhibitor ab141386 Z-Phe-Phe-FMK Ç 20μl >95% Irreversible cathepsin B and L inhibitor

Enzymes: Reductase

Cat No. Product Pack Sizes Purity Description ab141083 Atorvastatin hemicalcium salt Ç 10mg 50mg >99% Potent HMG-CoA reductase inhibitor ab120976 Bisdemethoxycurcumin Ç 5mg 25mg >98% Apoptotic anti-cancer, anti-inflammatory and anti-oxidant curcuminoid ab120651 Fluvastatin, Sodium Salt Ç É 50mg >99% Competitive HMG-CoA reductase inhibitor ab120614 Lovastatin (Mevinolin) Ç 10mg 50mg >98% Potent HMG CoA reductase inhibitor ab120652 Mevastatin Ç 10mg 50mg >98% Potent HMG-CoA reductase inhibitor ab120854 Mevastatin sodium salt Ç 5mg 25mg >98% HMG-CoA reductase inhibitor ab120505 Simvastatin 50mg 250mg >99% HMG-CoA reductase inhibitor

Enzymes: Secretase

Cat No. Product Pack Sizes Purity Description ab120633 DAPT Ç 10mg 50mg >99% γ-secretase inhibitor ab141414 L-685,458 Ç 250μg >98% Potent and selective γ-secretase inhibitor ab120650 Sulindac sulfide Ç 5mg 25mg >98% Active metabolite of Sulindac. COX-1/ 2 inhibitor.

Enzymes: Synthetase & synthase

Cat No. Product Pack Sizes Purity Description ab120165 1400W É 10mg 50mg >99% Selective iNOS inhibitor ab120123 Aminoguanidine hydrochloride É 100mg >98% NOS inhibitor ab141397 C75 Ç 1mg >98% Irreversible fatty acid synthase (FAS) inhibitor ab120137 NG-Monomethyl-L-arginine, monoacetate salt (L-NMMA) É 10mg 50mg >99% NOS inhibitor ab120233 7-Nitroindazole 50mg >98% NOS inhibitor ab120136 Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) É 100mg >98% NOS inhibitor ab120057 Spermidine hydrochloride É 100mg >99% Endogenous polyamine. nNOS inhibitor.

Enzymes: Telomerase

Cat No. Product Pack Sizes Purity Description ab120793 TMPyP4 tosylate Ç 50mg >98% Telomerase inhibitor. Binds and stabilizes DNA G-quadruplexes.

Enzymes: Transaminase

Cat No. Product Pack Sizes Purity Description ab120310 Vigabatrin É 10mg 50mg >98% Irreversible inhibitor of GABA transaminase

Refer to page 3 for symbol key 30 Discover more at www.abcam.com/biochemicals Catalog Update01 - International_Update 31/01/2013 08:18 Page 31

Enzymes: Transferase

Cat No. Product Pack Sizes Purity Description ab120892 Anacardic acid Ç 1mg 5mg 10mg 25mg >98% Histone acetyltransferase (HAT) inhibitor ab120842 5-Aza-2′-deoxycytidine (Decitabine) Ç É 10mg 50mg >99% Potent DNA methyltransferase inhibitor; epigenetic modifier ab120976 Bisdemethoxycurcumin Ç 5mg 25mg >98% Apoptotic anti-cancer, anti-inflammatory and anti-oxidant curcuminoid ab141407 BIX 01294 Ç 5mg 25mg >95% Potent G9a and G9a-like protein histone lysine methyltransferase inhibitor ab141399 Ethacrynic acid Ç 1g >99% Potent Glutathione S-transferase (GST) inhibitor ab120863 Hydralazine hydrochloride Ç 1g >99% DNA methylation inhibitor. Anti-hypertensive agent ab120955 Procainamide hydrochloride Ç 10g 25g >99% Sodium channel blocker. Specific DNA methyltransferase 1 inhibitor. ab120865 Procaine hydrochloride Ç 250mg >99% Na+ channel blocker. DNA methylation inhibitor. ab141013 RG 108 Ç 10mg 50mg >99% Novel, non-nucleoside DNA methyltransferase inhibitor ab120296 Tunicamycin from Streptomyces sp 10mg 50mg >99% Antibiotic. Protein glycosylation inhibitor

Signaling: Amyloidogenesis

Cat No. Product Pack Sizes Purity Description ab120479 Amyloid β Peptide (1-40) (human) 1mg 5mg >95% Amyloid β protein fragment. Implicated in Alzheimer’s disease. ab120301 Amyloid β Peptide (1-42) (human) 100μg 1mg >95% Predominant amyloid-β protein fragment ab120480 Amyloid β Peptide (25-35) (human) É 1mg >95% Highly toxic amyloid β protein fragment ab120481 Amyloid β (42-1) Peptide (human) 1mg >95% Inactive control for Amyloid β (1-42) (ab120301) peptide ab120834 Amyloid β Peptide (1-11) Ç 1mg >95% Amyloidogenic peptide ab120846 Amyloid β Peptide (1-28) Ç É 500μg 1mg >97% Amyloidogenic peptide ab120851 Amyloid β Peptide (1-38) (Aβ38) Ç 100μg >95% Toxic amyloid β peptide fragment ab120957 Amyloid β Peptide (1-40), (rat/mouse) Ç 1mg >95% Rat form of the amyloid β (1-40) peptide ab120959 Amyloid β Peptide (1-42) (rat/mouse) Ç 500μg >95% Rat form of the amyloid β (1-42) peptide ab120963 Amyloid β Peptide (1-43) (Aβ43) Ç 500μg >95% Highly toxic, amyloidogenic amyloid β peptide fragment ab120830 Amyloid β Peptide (10-20) Ç 1mg >95% Soluble amyloid β peptide fragment ab120838 Amyloid β Peptide (12-28) Ç 500μg 1mg >95% Toxic amyloid β peptide fragment ab120825 Amyloid β peptide (16-22) Ç 1mg >95% Amyloidogenic peptide forming an antiparallel β-sheet ab120969 Amyloid β Peptide (22-35) Ç 1mg >95% Cytotoxic amyloid β peptide fragment ab120974 Amyloid β Peptide (31-35) Ç 1mg >95% Amyloidogenic peptide ab120977 Amyloid β Peptide (35-25) Ç 1mg >95% Inactive control for Amyloid β (25-35) ab120992 Amyloid β Peptide (40-1) Ç 500μg >95% Inactive control for Amyloid β (1-40) (ab120479) peptide ab120723 Baicalein Ç 50mg >98% Flavonoid. Lipoxygenase inhibitor. ab120666 Cryptotanshinone Ç 10mg 50mg >99% STAT3 inhibitor with diverse biological activities ab141114 Galanthamine hydrobromide Ç 100mg >99% Alkaloid acetylcholinesterase inhibitor ab120817 [Gln11]-Amyloid β Peptide (1-28) Ç É 500μg 1mg >94% Homologous to Amyloid β protein. Induces amnesia. ab120820 [Gln22]-Amyloid β Peptide (1-40) Ç É 500μg 1mg >95% Mutant amyloid β (1-40) peptide ab141414 L-685,458 Ç 250μg >98% Potent and selective γ-secretase inhibitor ab120726 Resveratrol Ç 100mg 500mg >99% Antioxidant polyphenol with a multitude of biological activities ab141115 scyllo-Inositol Ç 5mg 25mg 100mg >98% Endogenous inositol isomer ab120751 Thioflavin T Ç 500mg >97% Fluorescent cell permeable amyloid binding benzothiazol salt ab141116 Tramiprosate Ç 1g 5g Binds soluble amyloid-β. Antifibrillogenic.

Signaling: Angiogenesis

Cat No. Product Pack Sizes Purity Description ab141339 AMG-Tie2-1 Ç 1mg 5mg >95% Highly potent, non-selective TIE2 (TEK) inhibitor ab120655 Celastrol from Celastrus scandens Ç 10mg 50mg >99% Anti-inflammatory and anti-proliferative agent ab141351 CYC-116 Ç 10mg 50mg >95% Potent Aurora kinase A/B and VEGFR inhibitor ab141049 Genipin Ç 25mg 100mg >99% Cell-permeable uncoupling protein 2 inhibitor ab120647 Honokiol Ç 10mg 25mg >98% Anti-inflammatory and chemotherapeutic agent ab120653 2-Methoxyestradiol Ç 10mg 50mg >98% Potent antitumor and antiangiogenic agent ab141066 Oleanolic acid Ç 100mg 500mg >98% Natural triterpenoid

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Signaling: Apoptosis & cell cycle

Cat No. Product Pack Sizes Purity Description ab141336 ABT-737 Ç 10mg 50mg >95% Novel and potent pan Bcl-2 inhibitor ab120901 ABT-869 (Linifanib) Ç 5mg 10mg >98% Potent VEGF and PDGF receptor tyrosine kinase inhibitor ab141059 AG-879 Ç 10mg >99% Selective TrkA receptor inhibitor ab141070 Alsterpaullone Ç 1mg >99% Potent cyclin-dependent kinase (CDK) and GSK-3β inhibitor ab141338 AMG-25 Ç 1mg 5mg >95% Potent c-Kit inhibitor ab141339 AMG-Tie2-1 Ç 1mg 5mg >95% Highly potent, non-selective TIE2 (TEK) inhibitor ab141060 Amifostine Ç 10mg 50mg >98% Broad spectrum cytoprotective agent; inactive prodrug of WR-1065 ab141069 3-Aminobenzamide (3-AB) Ç 100mg >99% PARP inhibitor ab120141 Apigenin 10mg 50mg >98% Anticancer agent ab141344 AZD7762 Ç 10mg 50mg >95% Novel checkpoint kinase inhibitor ab120723 Baicalein Ç 50mg >98% Flavonoid. Lipoxygenase inhibitor. ab141096 Bendamustine hydrochloride Ç 10mg 50mg >99% DNA alkylating agent ab120654 Betulinic acid Ç 10mg 50mg Anticancer agent. TGR5 agonist. ab141335 (R)-BI-2536 Ç 10mg 50mg >95% Potent PLK1 inhibitor ab120976 Bisdemethoxycurcumin Ç 5mg 25mg >98% Apoptotic anti-cancer, anti-inflammatory and anti-oxidant curcuminoid Ç ab141042 Brucine 5g >98% Positive allosteric modulator at M1 receptors. ab141420 Calcein AM Ç 50μg >95% Cell-permeable dye for determining cell viability ab120986 Cardamonin Ç 10mg 50mg >98% Anti-cancer, anti-inflammatory spice-derived chalcone analog ab141419 Catharanthine Ç 100mg 1g >98% Alkaloid. Vincristine and vinblastine precursor. ab120944 CAY10577 Ç 10mg 50mg >95% CK2 inhibitor ab120945 CAY10578 Ç 5mg 25mg >95% Selective, ATP competitive CK2 inhibitor ab141229 CCCP Ç 500mg >99% Potent mitochondrial oxidative phosphorylation uncoupler ab120655 Celastrol from Celastrus scandens Ç 10mg 50mg >99% Anti-inflammatory and anti-proliferative agent ab141398 Cisplatin Ç 100mg 1g >98% Potent, broad spectrum antineoplastic agent ab120355 Clioquinol 100mg 1g >97% Metal chelator and ionophore ab141183 Clomiphene citrate Ç 1g >98% Selective estrogen receptor modulator (SERM) ab120618 Curcumin (Diferuloylmethane) Ç 50mg 250mg >85% Flavonoid. Lipooxygenase inhibitor. Anti-oxidant, anti-inflammatory agent. ab120093 Cycloheximide É 100mg 1g >98% Protein synthesis inhibitor ab141240 Cyclophosphamide Ç 50mg >99% Alkylating agent; chemotherapeutic ab120727 Deferoxamine Mesylate Ç É 1g Iron chelator Ç ab120754 Doxazosin mesylate 50mg >99% Selective α1-adrenoceptor antagonist ab120629 Doxorubicin hydrochloride Ç É 10mg 50mg >98% Topoisomerase II inhibitor. Antibiotic with cytotoxic actions. ab120939 DRB (Benzimidazole) Ç 10mg 50mg >98% Casein kinase II inhibitor ab120645 Edaravone (MCI-186) Ç 50mg 250mg >99% Free radical scavenger with neuroprotective effects ab141061 Embelin Ç 10mg 50mg >98% Potent, cell-permeable inhibitor of X-linked inhibitor of apoptosis ab120716 (-)-Epigallocatechin Gallate Ç É 1mg 50mg >98% Potent anti-oxidant flavonoid ab120881 Erlotinib (CP-358,774) Ç 250mg 1g >98% Potent, selective and reversible EGFR tyrosine kinase inhibitor ab120081 FCCP 10mg 50mg >99% Mitochondrial oxidative phosphorylation inhibitor ab141048 Fludarabine (FAMP) Ç 10mg 50mg >98% DNA synthesis inhibitor. Prodrug converted to active metabolite F-ara-A. ab120354 Flufenamic acid 100mg >98% NSAID. COX inhibitor, channel blocker. ab141384 FMK negative control Ç 20μl >95% Negative control for caspase inhibitors ab141049 Genipin Ç 25mg 100mg >99% Cell-permeable uncoupling protein 2 inhibitor ab120647 Honokiol Ç 10mg 25mg >98% Anti-inflammatory and chemotherapeutic agent ab120960 Indirubin Ç 5mg 25mg >98% Potent cyclin-dependent kinase and GSK-3β inhibitor ab141014 IPA 3 Ç 10mg 50mg >97% Group I, p21-activated kinase (PAK) inhibitor ab141168 Isobavachalcone Ç 1mg >99% Akt inhibitor. Natural chalcone. ab141387 JC-1 Ç 5mg >98% Mitochondrial membrane-potential dye ab120357 Kaempferol 10mg 50mg >98% Phytoestrogen. Proapoptotic agent. ab120937 Kenpaullone Ç 5mg 10mg >98% CDK2, GSK3β and LCK inhibitor ab141097 β-Lapachone Ç 10mg 50mg >98% Topoisomerase I inhibitor ab120501 Leptomycin B (ethanol solution) 5μg 25μg >98% Antibiotic, antifungal. Inhibitor of CRM-1 mediated nuclear export.

Refer to page 3 for symbol key 32 Discover more at www.abcam.com/biochemicals Catalog Update01 - International_Update 31/01/2013 08:18 Page 33

Signaling: Apoptosis & cell cycle

Cat No. Product Pack Sizes Purity Description ab120662 Luteolin Ç 10mg 50mg >99% Antioxidant, anti-inflammatory, anti-cancer flavonoid ab120652 Mevastatin Ç 10mg 50mg >98% Potent HMG-CoA reductase inhibitor ab120854 Mevastatin sodium salt Ç 5mg 25mg >98% HMG-CoA reductase inhibitor ab120661 Minocycline hydrochloride Ç É 50mg >99% Antibiotic. Demonstrates multiple effects. ab141182 Mirin Ç 5mg 25mg >99% MRN-ATM complex inhibitor ab120797 Mitomycin C (MMC) Ç 2mg 10mg >99% Anti-cancer and antibiotic agent ab120499 Monensin sodium salt Ç 100mg 1g >95% Na+ ionophore ab120958 (±)-Naringenin Ç 50mg 100mg >98% Citrus flavonoid. Antioxidant, anti-inflammatory. ab120868 Niclosamide Ç 25g 50g >95% Antihelminthic, anticancer and protonophric agent. STAT3 inhibitor. Ç ab120864 Nicotinamide 100mg 1g >99% Amide form of vitamin B3 ab120943 NSC 210902 Ç 10mg 50mg >95% Selective, ATP competitive CK2 inhibitor ab120970 NU 7026 Ç 10mg 50mg >99% Novel, specific, reversible DNA-PK inhibitor ab141066 Oleanolic acid Ç 100mg 500mg >98% Natural triterpenoid ab120938 Olomoucine Ç 5mg 25mg >98% ATP-competitive CDK inhibitor ab141054 Oxaliplatin Ç 50mg >99% Platinum anticancer agent. Induces DNA cross-linking. ab120143 Paclitaxel 10mg 50mg >98% Anticancer agent ab120639 PD 0325901 Ç 10mg 50mg >99% Potent MEK 1 and 2 inhibitor ab141117 PD 173074 Ç 10mg 50mg >99% Potent FGFR1 and FGFR3 inhibitor ab141171 Pelitinib (EKB-569) Ç 5mg 25mg >98% Irreversible EGFR inhibitor ab120886 Pifithrin-μ Ç 10mg 50mg >98% Inhibitor of p53-mediated apoptosis ab120478 Pifithrin-α-HBr 10mg 50mg >98% p53 inhibitor ab120981 PJ34 hydrochloride Ç 10mg 50mg >98% Potent, selective PARP-1 inhibitor ab120859 PP 1 Ç 10mg >98% Potent Src family tyrosine kinase inhibitor

ab120879 Prostaglandin A2 Ç 1mg 5mg >98% Endogenous metabolite derived from arachidonic acid ab120961 Pterostilbene Ç 10mg >98% Antioxidant and anti-apoptotic agent; analog of resveratrol ab120304 Purvalanol A 1mg 10mg 50mg >98% Potent CDK inhibitor ab120305 Purvalanol B 10mg 50mg >98% CDK2 inhibitor ab120247 Quercetin 100mg >99% Anti-oxidative flavonoid ab141421 QVD-OPh Ç 1mg 5mg >95% Potent caspase activity inhibitor ab141389 QVD-OPh Negative Control Ç >95% Q-VD-OPh negative control ab120899 Salidroside Ç 1mg 5mg >97% Glycoside isolated from Rhodiola plants Ç ab120858 SCH79797 dihydrochloride 10mg 50mg >98% Potent and selective PAR1 antagonist ab120836 SD 169 Ç 10mg 50mg >99% Potent, selective and ATP competitive p38α MAPK inhibitor ab141108 SN 38 Ç 10mg 50mg >99% DNA topoisomerase I inhibitor. Active metabolite of CPT-11. ab141368 SU-5402 Ç 1mg 5mg >95% Potent FGFR and VEGFR inhibitor ab120650 Sulindac sulfide Ç 5mg 25mg >98% Active metabolite of Sulindac. COX-1/ 2 inhibitor. ab120988 TBB Ç 10mg 50mg >98% Selective, cell-permeable casein kinase-2 (CK2) inhibitor ab141055 Temozolomide Ç 10mg 50mg >99% DNA alkylating/methylating chemotherapeutic agent ab120889 Tenovin-1 Ç 10mg 50mg >98% p53 activator ab120032 (±)-Thalidomide 100mg >99% Immunomodulator and anticancer agent ab120728 trans-Retinoic Acid Ç 50mg 500mg >99% Vitamin A metabolite. Stem cell differentiator. ab120720 Triptolide from Tripterygium wilfordii Ç 1mg 10mg >99% Anti-inflammatory agent with multiple biological activities. ab141369 Vargatef Ç 10mg 50mg >95% Potent VEGFR, PDGFR and FGFR inhibitor ab120644 Withaferin A from Withania somnifera Ç 1mg >98% Naturally occurring withanolide/steroidal lactone with anti-cancer properties ab120897 XAV939 Ç 10mg 25mg >98% Potent tankyrase inhibitor. Inhibitor of Wnt/β-catenin signaling. ab141383 Z-ATAD-FMK Ç 1mg 5mg >95% Caspase 12 inhibitor ab120488 Z-D(OMe)E(OMe)VD(OMe)-FMK 1mg 5mg >90% Cell permeable caspase-3 inhibitor ab141382 Z-IETD-FMK Ç 1mg 5mg >99% Caspase 8 inhibitor ab120489 Z-LE(OMe)VD(OMe)-FMK 1mg 5mg >90% Cell permeable derivative of caspase-4 inhibitor Z-LEVD-FMK ab120487 Z-VAD(OMe)-FMK 1mg 5mg >90% Cell permeable, irreversible pan-caspase inhibitor ab120382 Z-VAD-FMK 1mg 5mg >98% Irreversible general caspase inhibitor ab141388 Z-YVAD-FMK Ç 1mg 5mg >98% Irreversible caspase 1 inhibitor

Discover more at www.abcam.com/biochemicals 33 Catalog Update01 - International_Update 31/01/2013 08:18 Page 34

Signaling: Ca2+ Signaling

Cat No. Product Pack Sizes Purity Description ab120287 A23187 (Calcimycin) 10mg 50mg >99% Ca2+ ionophore ab120210 ω-Agatoxin IVA É 10μg 100μg >95% Ca2+ channel blocker (P and Q type) ab120124 2-APB 100mg >98% Ca2+ release modulator ab120503 BAPTA-AM Ç 25mg >98% Selective Ca2+ chelator. Analogue of BAPTA. ab120449 BAPTA sodium salt Ç É 250mg 1g 5g >98% Selective Ca2+ chelator ab120658 Calmidazolium chloride Ç 10mg >98% Calmodulin inhibitor ab120012 CGP 37157 10mg 50mg >99% Na+-Ca2+ exchange inhibitor ab120215 ω-Conotoxin GVIA É Ë 500μg 1mg >96% Ca2+ channel blocker (N type) ab120211 ω-Conotoxin MVIIC É Ë 100μg 500μg >95% Ca2+ channel blocker (P and Q-type) ab120300 Cyclopiazonic acid from Penicillium grisefulvum 10mg 50mg >99% Ca2+-ATPase inhibitor ab120333 D890 É 10mg 50mg >99% Intracellular Ca2+ channel blocker ab120260 Diltiazem É 1g >99% L-type Ca2+ channel antagonist ab120873 Fura-2 AM (Fura-2 acetoxymethyl ester) Ç 1mg >95% Selective Ca2+ chelator; fluorescent indicator ab120219 Gabapentin É 10mg 50mg >99% α2δ ligand ab120863 Hydralazine hydrochloride Ç 1g >99% DNA methylation inhibitor. Anti-hypertensive agent ab120370 Ionomycin (free acid) 1mg 5mg >99% Ca2+ ionophore ab120116 Ionomycin Ca2+ Salt 1mg 5mg >99% Ca2+ ionophore ab120142 Isradipine 10mg 50mg >98% L-type Ca2+ channel blocker ab120419 K252a 200μg 1mg >99% Highly potent inhibitor of protein and CAM kinases ab120284 KB-R7943 10mg 50mg >99% NCX inhibitor. TRPC blocker.

ab120421 KN-62 1mg 5mg >98% CaM kinase II inhibitor. P2X7 antagonist. ab120980 KN-93 (water soluble) Ç 1mg >99% Potent, specific CaMK II inhibitor ab120958 (±)-Naringenin Ç 50mg 100mg >98% Citrus flavonoid. Antioxidant, anti-inflammatory. ab120531 Nicardipine hydrochloride Ç 1g 5g >99% L-type Ca2+ channel antagonist ab120135 Nifedipine 250mg 1g >99% L-type Ca2+ channel blocker ab120138 Nimodipine 100mg 500mg >98% L-type Ca2+ channel blocker ab120139 Nitrendipine 100mg 500mg >98% L-type Ca2+ channel blocker ab120264 Ruthenium red É 100mg Calcium signalling inhibitor ab120083 Ryanodine 1mg >98% Ca2+ release modulator ab120280 SKF 96365 É 10mg 50mg >99% Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry. É 2+ ab120259 SNX 482 10μg 100μg >96% R-Type Ca (Cav2.3) channel blocker ab120276 tBuBHQ (BHQ) 100mg 500mg >99% Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor ab120286 Thapsigargin 1mg >98% Ca2+-ATPase inhibitor ab120739 Trifluoperazine dihydrochloride Ç 1g >99% Cell permeable calmodulin antagonist ab120140 Verapamil hydrochloride É 1g >99% L-type Ca2+ channel blocker Ç ab120914 Xestospongin C 50μg 100μg >90% Potent, selective, reversible IP3 receptor antagonist ab120369 Zonisamide 10mg 50mg >99% Non-selective Na+ / Ca2+channel blocker

Signaling: Cytoskeleton & motor proteins

Cat No. Product Pack Sizes Purity Description ab120491 (S)-(-)-Blebbistatin Ç 1mg 5mg >99% Selective myosin II ATPase activity inhibitor ab120425 (±)-Blebbistatin 5mg 25mg >98% Potent, selective, inhibitor of myosin II ab120299 Brefeldin A 5mg 25mg >99% Inihibitor of ADP-ribosylation factor ab141419 Catharanthine Ç 100mg 1g >98% Alkaloid. Vincristine and vinblastine precursor. ab141231 CK 666 Ç 10mg 50mg >99% Potent inhibitor of actin polymerization ab120663 Colchicine from Colchicum autumnale Ç É 1g >99% Inhibitor of microtubule formation ab120925 Combrestatin A4 Ç 10mg 50mg >98% Potent inhibitor of tubulin polymerization ab120292 Exo-1 10mg 50mg >99% Vesicular trafficking inhibitor ab141409 Jasplakinolide Ç 50μg >95% Actin polymerization and stabilization inducer ab120819 JK 184 Ç 10mg 50mg >99% Potent Hedgehog signaling inhibitor ab120793 TMPyP4 tosylate Ç 50mg >98% Telomerase inhibitor. Binds and stabilizes DNA G-quadruplexes. ab120226 Vincristine sulfate salt É 5mg 25mg >98% Microtubule inhibitor ab141085 Wiskostatin Ç 10mg 50mg >99% Selective N-WASP inhibitor

Signaling: DNA, RNA & protein synthesis

Cat No. Product Pack Sizes Purity Description ab120495 Anisomycin 10mg 50mg >98% Protein synthesis inhibitor ab141064 Azithromycin dihydrate Ç 50mg Macrolide antibiotic ab141096 Bendamustine hydrochloride Ç 10mg 50mg >99% DNA alkylating agent

Refer to page 3 for symbol key 34 Discover more at www.abcam.com/biochemicals Catalog Update01 - International_Update 31/01/2013 08:18 Page 35

Signaling: DNA, RNA & protein synthesis

Cat No. Product Pack Sizes Purity Description ab141202 Clarithromycin Ç 100mg >98% Macrolide antibiotic ab141412 Clasto lactacystin β lactone Ç 100μg >95% Cell-permeable and irreversible proteasome inhibitor ab141107 CPT 11 (Irinotecan) Ç 10mg 50mg >99% Potent DNA topoisomerase I inhibitor ab120666 Cryptotanshinone Ç 10mg 50mg >99% STAT3 inhibitor with diverse biological activities ab141394 Daunorubicin hydrochloride Ç 10mg 50mg >95% DNA and RNA synthesis inhibitor ab141390 Dithiothreitol (DTT) Ç 1ml >99% Reducing reagent ab120939 DRB (Benzimidazole) Ç 10mg 50mg >98% Casein kinase II inhibitor ab141205 Erythromycin Ç 1g 5g Macrolide antibiotic ab120904 GANT 61 Ç 10mg 50mg >98% Selective GLI1 and 2 inhibitor ab120922 HU-331 Ç 5mg 25mg >95% Potent cannabinoid quinone. Topoisomerase II inhibitor. ab141071 10-Hydroxycamptothecin Ç 10mg 50mg >99% DNA topoisomerase I inhibitor ab141275 N-Hydroxysuccinimide Ç 5g >99% Amine-reactive compound ab141192 IQDMA Ç 10mg >98% Cell-permeable STAT5 inhibitor ab141411 Lactacystin Ç 200μg >95% Cell-permeable, potent and selective proteasome inhibitor ab141097 β-Lapachone Ç 10mg 50mg >98% Topoisomerase I inhibitor ab141182 Mirin Ç 5mg 25mg >99% MRN-ATM complex inhibitor ab120797 Mitomycin C (MMC) Ç 2mg 10mg >99% Anti-cancer and antibiotic agent ab141041 Mitoxantrone dihydrochloride Ç 50mg >98% Type II topoisomerase inhibitor ab120664 Mycophenolic Acid Ç 100mg >99% Immunosuppressant. Inosine monophosphate dehydrogenase inhibitor. ab120868 Niclosamide Ç 25g 50g >95% Antihelminthic, anticancer and protonophric agent. STAT3 inhibitor. ab141054 Oxaliplatin Ç 50mg >99% Platinum anticancer agent. Induces DNA cross-linking. ab120886 Pifithrin-μ Ç 10mg 50mg >98% Inhibitor of p53-mediated apoptosis ab120478 Pifithrin-α-HBr 10mg 50mg >98% p53 inhibitor ab120660 Ribavirin Ç É 10mg 50mg >99% Anti-viral nucleoside ab141108 SN 38 Ç 10mg 50mg >99% DNA topoisomerase I inhibitor. Active metabolite of CPT-11. ab120952 Stattic Ç 10mg 50mg >99% Selective STAT3 inhibitor ab141055 Temozolomide Ç 10mg 50mg >99% DNA alkylating/methylating chemotherapeutic agent ab120889 Tenovin-1 Ç 10mg 50mg >98% p53 activator ab120659 Tobramycin, free base Ç É 100mg 500mg >98% Ribosomal translation inhibitor ab120897 XAV939 Ç 10mg 25mg >98% Potent tankyrase inhibitor. Inhibitor of Wnt/β-catenin signaling.

Signaling: Endocytosis & exocytosis

Cat No. Product Pack Sizes Purity Description ab120730 Chlorpromazine hydrochloride Ç É 1g 5g >99% Typical antipsychotic. Non-selective receptor antagonist. ab120474 Dynamin Inhibitors: Dynole™ Series Kit fi 1kit Dynamin inhibitor kit from the Dynole™ series ab120473 Dynamin Inhibitors: MiTMAB™ Series Kit fi 1kit Dynamin inhibitor kit from the MiTMAB™ series ab120475 Dynamin Inhibitors: Iminodyn™ Series Kit fi 1kit Dynamin inhibitor kit from the Iminodyn™ series ab120468 Dynamin Inhibitors Toolbox fi 1kit Dynamin inhibitor kit from the MiTMAB™, Dynole™ and Iminodyn™ chemical series. ab120689 Dyngo-4a™ Ç fi 5mg Novel, highly potent dynamin inhibitor. Dynasore (ab120192) analog. ab120464 Dynole-31-2™ fi 5mg >98% Negative control for Dynole 34-2™ ab120463 Dynole-34-2™ fi 5mg >98% Potent dynamin I and dynamin II inhibitor ab120112 Genistein 10mg 50mg 100mg >99% Protein tyrosine kinase inhibitor. Anticancer agent. ab120462 Iminodyn-17™ fi 5mg >98% Negative control for Iminodyn-22™ ab120461 Iminodyn-22™ fi 5mg >98% Potent, broad spectrum dynamin inhibitor ab120466 MiTMAB™ É fi 5mg Cell permeable dynamin I and dynamin II inhibitor ab120467 OcTMAB™ fi 5mg >98% Cell permeable dynamin I and dynamin II inhibitor ab120685 Pitstop 1™ Ç fi 5mg Novel, selective clathrin inhibitor ab120686 Pitstop 1™ - negative control Ç fi 5mg Negative control for clathrin inhibitor Pitstop 1™ ab120687 Pitstop 2™ Ç fi 5mg Novel, selective cell permeable clathrin inhibitor ab120688 Pitstop 2™ - negative control Ç fi 5mg Negative control for clathrin inhibitor Pitstop 2™ ab120476 Pro-Myristic Acid fi 5mg Negative control for MiTMAB™ and OcTMAB™ ab120796 Rhodadyn B10™ Ç fi 5mg >95% Negative control for Rhodadyn C10™ ab120795 Rhodadyn C10™ Ç fi 5mg >95% Highly potent cell permeable dynamin I inhibitor ab120465 RTIL-13™ fi 5mg >98% Potent dynamin I and II inhibitor

Discover more at www.abcam.com/biochemicals 35 Catalog Update01 - International_Update 31/01/2013 08:18 Page 36

Signaling: Epigenetics: DNA Methyltransferase (DNMT)

Cat No. Product Pack Sizes Purity Description ab120842 5-Aza-2′-deoxycytidine (Decitabine) Ç É 10mg 50mg >99% Potent DNA methyltransferase inhibitor; epigenetic modifier ab120976 Bisdemethoxycurcumin Ç 5mg 25mg >98% Apoptotic anti-cancer, anti-inflammatory and anti-oxidant curcuminoid ab120973 Chlorogenic acid hemihydrate Ç 250mg 1g >99% Antioxidant with a variety of biological effects ab120863 Hydralazine hydrochloride Ç 1g >99% DNA methylation inhibitor. Anti-hypertensive agent ab120955 Procainamide hydrochloride Ç 10g 25g >99% Sodium channel blocker. Specific DNA methyltransferase 1 inhibitor. ab120865 Procaine hydrochloride Ç 250mg >99% Na+ channel blocker. DNA methylation inhibitor. ab141013 RG 108 Ç 10mg 50mg >99% Novel, non-nucleoside DNA methyltransferase inhibitor ab141055 Temozolomide Ç 10mg 50mg >99% DNA alkylating/methylating chemotherapeutic agent

Signaling: Epigenetics: Histone Acetyltransferase (HAT)

Cat No. Product Pack Sizes Purity Description ab120892 Anacardic acid Ç 1mg 5mg 10mg 25mg >98% Histone acetyltransferase (HAT) inhibitor

Signaling: Epigenetics: Histone Deacetylase (HDAC)

Cat No. Product Pack Sizes Purity Description ab120860 (+)-Abscisic acid Ç 1mg >99% Phytohormone; produced by a variety of cells in humans and animals ab120862 Caffeic acid Ç 250mg 1g >98% Specific NF-κB inhibitor ab141181 Cambinol Ç 5mg 25mg >98% SIRT1/2 inhibitor ab141401 M344 Ç 1mg >98% Novel and selective HDAC6 inhibitor Ç ab120864 Nicotinamide 100mg 1g >99% Amide form of vitamin B3 ab120883 Scriptaid Ç 10mg 25mg >98% HDAC inhibitor ab141253 Sodium 4-phenylbutyrate Ç 100mg >99% Histone deacetylase inhibitor ab120948 Sodium butyrate Ç 50mg 250mg 1g >98% Histone deacetylase inhibitor ab141120 Splitomicin Ç 10mg 50mg >98% Sir2P inhibitor ab141415 Tubastatin A Ç 1mg 5mg >98% Potent, selective HDAC6 inhibitor ab120745 Valproic acid, sodium salt Ç É 100mg Histone deacetylase inhibitor

Signaling: Epigenetics: Histone Methyltransferase

Cat No. Product Pack Sizes Purity Description ab141407 BIX 01294 Ç 5mg 25mg >95% Potent G9a and G9a-like protein histone lysine methyltransferase inhibitor

Signaling: Extracellular matrix & cell adhesion

Cat No. Product Pack Sizes Purity Description ab141092 Gly-Arg-Gly-Asp-Ser Ç 1mg 5mg >98% Synthetic integrin antagonist ab141353 GSK-25 Ç 1mg 5mg >95% ROCK inhibitor ab120306 HA-1077 (Fasudil) É 10mg 50mg >98% ROCK2 inhibitor ab120661 Minocycline hydrochloride Ç É 50mg >99% Antibiotic. Demonstrates multiple effects. ab141359 PF431396 Ç 1mg 5mg >95% Potent dual FAK/Pyk2 inhibitor ab141360 PF-562271 Ç 1mg 5mg >95% Potent, reversible, ATP-competitive FAK/Pyk2 inhibitor ab141196 1,10-Phenanthroline Ç 5g 25g >99% Membrane permeable chelating agent. Metalloprotease inhibitor. ab141093 Tyr-Ile-Gly-Ser-Arg Ç 1mg 5mg >98% Peptide antagonist derived from the laminin β1 chain ab120129 Y-27632 dihydrochloride É 1mg 10mg 50mg >99% Selective Rho kinase inhibitor

Signaling: Heat shock proteins

Cat No. Product Pack Sizes Purity Description ab120655 Celastrol from Celastrus scandens Ç 10mg 50mg >99% Anti-inflammatory and anti-proliferative agent ab120896 Geldanamycin Ç 1mg 5mg >98% Selective Hsp90 inhibitor ab120886 Pifithrin-μ Ç 10mg 50mg >98% Inhibitor of p53-mediated apoptosis

Refer to page 3 for symbol key 36 Discover more at www.abcam.com/biochemicals Catalog Update01 - International_Update 31/01/2013 08:18 Page 37

Signaling: Immunomodulators

Cat No. Product Pack Sizes Purity Description ab120860 (+)-Abscisic acid Ç 1mg >99% Phytohormone; produced by a variety of cells in humans and animals ab141200 Ampicillin trihydrate Ç 5g 25g >99% β-lactam antibiotic ab120636 Andrographolide Ç 100mg >99% Potent anti-inflammatory agent ab120898 AS-041164 Ç 5mg 25mg >98% Potent and selective PI3Kγ inhibitor ab141016 Ascomycin Ç 1mg >98% Calcineurin/PP2B inhibitor. Immunosuppressant and antifungal activity. ab141417 Bestatin Ç 25mg 100mg >99% Aminopeptidase inhibitor; immunomodulator ab120976 Bisdemethoxycurcumin Ç 5mg 25mg >98% Apoptotic anti-cancer, anti-inflammatory and anti-oxidant curcuminoid ab120986 Cardamonin Ç 10mg 50mg >98% Anti-cancer, anti-inflammatory spice-derived chalcone analog ab141090 Chlorhexidine Ç 1g 5g >98% Broad spectrum anti-microbial agent ab141202 Clarithromycin Ç 100mg >98% Macrolide antibiotic ab141203 Dapsone Ç 250mg >99% Antibacterial and anti-inflammatory agent ab141204 Daptomycin Ç 10mg 50mg >98% Lipopeptide antibiotic ab120727 Deferoxamine Mesylate Ç É 1g Iron chelator ab141119 Epicatechin Ç 1mg 5mg >99% Flavonoid with multiple biological effects ab141086 Etodolac Ç 10mg 50mg >99% COX-2 inhibitor; NSAID ab120223 FK506 (Tacrolimus) 10mg 50mg >98% Immunosuppressant ab141049 Genipin Ç 25mg 100mg >99% Cell-permeable uncoupling protein 2 inhibitor ab141250 Hydrocortisone Ç 1g 5g >99% Adrenal glucocorticoid; immunosuppressant ab120827 Hydroxychloroquine sulfate Ç 5mg 25mg >99% Anti-inflammatory and anti-malarial agent. ab141015 (S)-(+)-Ibuprofen Ç 100mg >99% Non-selective COX inhibitor ab141030 Imipenem Ç 5mg 25mg >98% Highly potent, broad spectrum β-lactam antibiotic ab141410 Imiquimod Ç 100mg 500mg >95% Toll-like receptor 7 agonist; immunomodulator ab120724 Inosine Ç É 100mg 1g >99% Purine nucleoside. Adenosine metabolite. ab141409 Jasplakinolide Ç 50μg >95% Actin polymerization and stabilization inducer ab141217 Levamisole hydrochloride Ç 250mg >99% Alkaline phosphatase inhibitor. Selective agonist at nematode nAChRs. ab120975 Meropenem trihydrate Ç 10mg 50mg >98% Broad-spectum β-lactam antibiotic ab141218 Metronidazole Ç 5g 25g >99% Antiparasitic and antibacterial compound ab141195 (±)-Miconazole nitrate Ç 1g 5g >99% Imidazole antifungal agent ab120661 Minocycline hydrochloride Ç É 50mg >99% Antibiotic. Demonstrates multiple effects. ab120664 Mycophenolic Acid Ç 100mg >99% Immunosuppressant. Inosine monophosphate dehydrogenase inhibitor. Ç ab120864 Nicotinamide 100mg 1g >99% Amide form of vitamin B3 ab141066 Oleanolic acid Ç 100mg 500mg >98% Natural triterpenoid ab120725 Pentoxifylline Ç É 1g 5g >99% Phosphodiesterase inhibitor. Cytokine inhibitor. ab120894 PF-3845 Ç 10mg 25mg >98% Selective, irreversible FAAH inhibitor ab141400 Pimecrolimus Ç 5mg 25mg >98% Non-steroidal anti-inflammatory cytokine inhibitor; cell-selective ab120880 Prostratin Ç 500μg 1mg >98% PKC activator; reactivates HIV-1 latency ab120224 Rapamycin 1mg 5mg >98% Immunosuppressant ab141145 Rutaecarpine Ç 5mg 25mg >99% Indoloquinazoline alkaloid derived from Evodia rutaecarpa ab120899 Salidroside Ç 1mg 5mg >97% Glycoside isolated from Rhodiola plants ab141190 Sinomenine hydrochloride Ç 50mg >99% Natural anti-inflammatory morphinan analog; potently releases histamine ab120032 (±)-Thalidomide 100mg >99% Immunomodulator and anticancer agent ab120720 Triptolide from Tripterygium wilfordii Ç 1mg 10mg >99% Anti-inflammatory agent with multiple biological activities. ab141067 Voriconazole (UK-109, 496) Ç 10mg 50mg >99% Potent and broad-spectrum anti-fungal agent Ç ab141149 [D-Trp8]-γ-MSH 1mg >98% Selective melanocortin 3 (MC3) receptor agonist

Signaling: Lipid Signaling

Cat No. Product Pack Sizes Purity Description ab141121 (±)-Acetylcarnitine chloride Ç 250mg 1g >98% Important mediator in lipid metabolism Ç ab120905 AH 6809 10mg 50mg >98% EP1 and EP2 antagonist ab120916 Arachidonic acid Ç 50mg 100mg >98% ω-6 polyunsaturated fatty acid, precursor of eicosanoids ab141397 C75 Ç 1mg >98% Irreversible fatty acid synthase (FAS) inhibitor Ç ab141034 (±)-Cloprostenol sodium 10mg >99% Potent, water soluble PGF2α analog ab120618 Curcumin (Diferuloylmethane) Ç 50mg 250mg >85% Flavonoid. Lipooxygenase inhibitor. Anti-oxidant, anti-inflammatory agent.

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Signaling: Lipid Signaling

Cat No. Product Pack Sizes Purity Description ab120621 Diclofenac Sodium Salt Ç 1g >99% Potent cyclo-oxygenase inhibitor ab120906 16,16-Dimethyl prostaglandin E2 Ç 1mg 5mg >98% Competitive 15-hydroxy PGDH inhibitor. Synthetic

derivative of prostaglandin E2. ab120716 (-)-Epigallocatechin Gallate Ç É 1mg 50mg >98% Potent anti-oxidant flavonoid ab141086 Etodolac Ç 10mg 50mg >99% COX-2 inhibitor; NSAID ab141015 (S)-(+)-Ibuprofen Ç 100mg >99% Non-selective COX inhibitor Ç ab120911 Iloprost 1mg 5mg >97% Prostaglandin (PGI2) analogue ab141387 JC-1 Ç 5mg >98% Mitochondrial membrane-potential dye ab141035 (S)-Ketoprofen Ç 1g >98% Highly potent COX1/2 inhibitor. Non-steroidal anti-inflammatory drug (NSAID). Ç ab120947 L-161,982 10mg 50mg >98% Potent and selective EP4 receptor antagonist Ç ab120946 L-655,240 1mg 5mg >98% Potent thromboxane A2 receptor antagonist ab120614 Lovastatin (Mevinolin) Ç 10mg 50mg >98% Potent HMG CoA reductase inhibitor ab120662 Luteolin Ç 10mg 50mg >99% Antioxidant, anti-inflammatory, anti-cancer flavonoid ab120243 LY 294002 5mg 25mg >99% PI3-kinase inhibitor Ç ab120902 Misoprostol 1mg 10mg >98% Cytoprotective PGE2 analog ab141033 Naproxen sodium Ç 50mg >99% Non-selective COX inhibitor ab120145 Nicotinic acid (Niacin) É 10g >98% Antidyslipidemic agent ab120295 NS 398 10mg 50mg >98% COX-2 inhibitor ab141001 (±)-Octanoylcarnitine chloride Ç 50mg >98% Intermediate in lipid metabolism ab141393 Oxidized Glutathione (GSSG) Ç 1g >95% Hydrogen acceptor in determination of NADP and NADPH ab120878 4-Oxo-2-nonenal (4-ONE) Ç 1mg 5mg >98% Lipid peroxidation product. TRPA1 activator. ab141122 (±)-Palmitoylcarnitine chloride Ç 100mg >98% Protein kinase C (PKC) inhibitor. Intermediate in lipid metabolism. ab141110 Piroxicam Ç 100mg >99% Reversible, selective cyclooxygenase-1 (COX-1) inhibitor ab141123 (±)-Propionylcarnitine chloride Ç 50mg >98% Intermediate in lipid metabolism Ç ab120879 Prostaglandin A2 1mg 5mg >98% Endogenous metabolite derived from arachidonic acid Ç ab120888 Prostaglandin D2 1mg 5mg >99% High affinity DP1 and CRTH2 receptor agonist; major prostaglandin produced by mast cells. Ç ab120909 Prostaglandin G2 100μg 500μg >95% Major prostanoid in the COX pathway. Ç ab120910 Prostaglandin H2 100μg 500μg >95% Major prostanoid; important precursor in eicosanoid synthesis Ç ab120912 Prostaglandin I2 sodium salt 1mg 5mg >99% Potent vasodilator and inhibitor of platelet aggregation Ç ab120913 Prostaglandin J2 1mg 5mg >95% Endogenous product of inflammation; PGD2 analog ab120505 Simvastatin 50mg 250mg >99% HMG-CoA reductase inhibitor ab120650 Sulindac sulfide Ç 5mg 25mg >98% Active metabolite of Sulindac. COX-1/ 2 inhibitor. Ç ab120907 Sulprostone 1mg 5mg >98% Selective EP1/ EP3 receptor agonist. PGE2 analog. Ç ab120908 U-51605 100μg 500μg >98% Selective PGI2 and TXA2 synthase inhibitor.

PGH2 analog. ab120927 URB754 Ç 10mg 50mg >98% Monoacylglycerol lipase inhibitor ab120148 Wortmannin 1mg 5mg >98% PI3-kinase inhibitor

Signaling: Stem Cells

Cat No. Product Pack Sizes Purity Description ab141024 AM 80 Ç 10mg 50mg >98% Selective retinoic acid receptor α/β (RARα/β) agonist ab120718 AMD3100 octahydrochloride Ç É 10mg >99% Highly selective CXCR4 antagonist ab120891 BIO Ç 10mg 25mg >98% Potent, selective, reversible GSK3 inhibitor; cell-permeable ab120890 CHIR99021 Ç 1mg 5mg >98% Potent, highly selective GSK3 inhibitor ab120807 EC-23 Ç 10mg 50mg >98% Photostable synthetic retinoid. ATRA analog. ab141180 Kartogenin Ç 5mg 25mg >98% Promotes differentiation of human mesenchymal stems cells into chondrocytes ab120853 Lithium chloride Ç 1g 5g >99% GSK-3β inhibitor ab120893 Neurodazine Ç 10mg 50mg >98% Induces neurogenesis in skeletal muscle cells ab120920 Oxy-16 Ç 1mg 5mg >95% Oxysterol; Hh pathway activator ab141117 PD 173074 Ç 10mg 50mg >99% Potent FGFR1 and FGFR3 inhibitor Ç ab120921 Reversine 1mg 5mg >98% Potent selective A3 receptor antagonist ab141013 RG 108 Ç 10mg 50mg >99% Novel, non-nucleoside DNA methyltransferase inhibitor ab141190 Sinomenine hydrochloride Ç 50mg >99% Natural anti-inflammatory morphinan analog; potently releases histamine ab120978 Stauprimide Ç 100μg 500μg >99% Stem cell differentiation primer. Staurosporine analog. ab120728 trans-Retinoic Acid Ç 50mg 500mg >99% Vitamin A metabolite. Stem cell differentiator.

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Signal transduction: Cytokines, NF-κB & IκB

Cat No. Product Pack Sizes Purity Description ab120718 AMD3100 octahydrochloride Ç É 10mg >99% Highly selective CXCR4 antagonist ab120862 Caffeic acid Ç 250mg 1g >98% Specific NF-κB inhibitor ab120655 Celastrol from Celastrus scandens Ç 10mg 50mg >99% Anti-inflammatory and anti-proliferative agent ab120647 Honokiol Ç 10mg 25mg >98% Anti-inflammatory and chemotherapeutic agent ab120662 Luteolin Ç 10mg 50mg >99% Antioxidant, anti-inflammatory, anti-cancer flavonoid ab141406 PDTC (Ammonium pyrrolidinedithiocarbamate) Ç 100mg >98% Selective NF-κB inhibitor; antioxidant ab120725 Pentoxifylline Ç É 1g 5g >99% Phosphodiesterase inhibitor. Cytokine inhibitor. ab141400 Pimecrolimus Ç 5mg 25mg >98% Non-steroidal anti-inflammatory cytokine inhibitor; cell-selective ab120746 Sodium salicylate Ç É 5g >99% Cell permeable anti-inflammatory agent ab120643 Tranilast Ç 10mg 50mg >99% Anti-inflammatory agent ab120720 Triptolide from Tripterygium wilfordii Ç 1mg 10mg >99% Anti-inflammatory agent with multiple biological activities.

Signal transduction: G-Protein related

Cat No. Product Pack Sizes Purity Description ab120860 (+)-Abscisic acid Ç 1mg >99% Phytohormone; produced by a variety of cells in humans and animals ab141408 QS11 Ç 5mg >98% ARFGAP1 inhibitor. Wnt/β-catenin pathway modulator.

Signal transduction: Hedgehog signaling

Cat No. Product Pack Sizes Purity Description ab120392 Cyclopamine 1mg 5mg >97% Hh signaling inhibitor ab120665 GANT58 Ç 10mg 50mg >99% Downstream Hh signaling inhibitor ab120904 GANT 61 Ç 10mg 50mg >98% Selective GLI1 and 2 inhibitor ab120815 Jervine Ç 1mg 5mg >98% Smoothened inhibitor ab120819 JK 184 Ç 10mg 50mg >99% Potent Hedgehog signaling inhibitor ab141191 MRT-10 Ç 10mg 50mg >99% Novel, high affinity smoothened (Smo) antagonist ab120920 Oxy-16 Ç 1mg 5mg >95% Oxysterol; Hh pathway activator ab120933 Purmorphamine Ç 5mg 25mg >98% Smoothened receptor agonist

Signal transduction: Inositol & cAMP signaling

Cat No. Product Pack Sizes Purity Description ab120493 Adenosine 3′,5′-cyclic monophosphate (cAMP) É 1g 5g 25g >98% Second messenger. PKA activator. ab120124 2-APB 100mg >98% Ca2+ release modulator ab120424 8-(4-Chlorophenylthio)adenosine 3’,5’-cyclic monophosphate (8-CPT-cAMP) É 20mg 100mg >98% Cell permeable cAMP analogue, protein kinase modulator ab120884 3,5-dimethyl PIT-1 Ç 5mg 25mg >98% PIP3/protein binding inhibitor ab120058 Forskolin 10mg 50mg 100mg >98% Adenylyl cyclase activator ab120341 H89 dihydrochloride 1mg 10mg 50mg >98% Kinase inhibitor ab120190 NKH 477 (Colforsin daropate) É 10mg 50mg >98% Water-soluble analogue of forskolin (ab120058), an adenylyl cyclase activator ab120942 Papaverine Ç 250mg 1g >98% Potent PDE inhibitor ab120885 PIT-1 Ç 10mg 50mg >98% PIP3/protein binding inhibitor ab141115 scyllo-Inositol Ç 5mg 25mg 100mg >98% Endogenous inositol isomer ab120642 SQ 22536 Ç 10mg 50mg >99% Non-competitive adenylyl cyclase inhibitor Ç ab120914 Xestospongin C 50μg 100μg >90% Potent, selective, reversible IP3 receptor antagonist

Signal transduction: JAK/STAT

Cat No. Product Pack Sizes Purity Description ab120950 AG 490 Ç 10mg 50mg >99% JAK2/3 inhibitor ab141342 AZ-960 Ç 1mg 5mg >95% Novel, potent and selective JAK2 inhibitor ab141371 Baricitinib Phosphate Ç 1mg 5mg >95% JAK1/2 inhibitor ab141345 Bayer-18 Ç 1mg 5mg >95% Potent and selective TYK2 inhibitor ab141378 CEP-33779 Ç 1mg 5mg >95% Selective JAK2 inhibitor ab120666 Cryptotanshinone Ç 10mg 50mg >99% STAT3 inhibitor with diverse biological activities ab141379 GPLG0634 Ç 1mg 5mg >95% JAK1/2 inhibitor ab141356 INCB018424 (Ruxolitinib) Ç 10mg 50mg >95% Potent, selective JAK1 and JAK2 inhibitor ab141192 IQDMA Ç 10mg >98% Cell-permeable STAT5 inhibitor ab141358 Merck 5 Ç 1mg 5mg >95% Potent, reversible ATP-competitive JAK inhibitor ab141372 Momelotinib Ç 10mg 50mg >95% Selective JAK2 inhibitor

Discover more at www.abcam.com/biochemicals 39 Catalog Update01 - International_Update 31/01/2013 08:18 Page 40

Signal transduction: JAK/STAT

Cat No. Product Pack Sizes Purity Description ab120868 Niclosamide Ç 25g 50g >95% Antihelminthic, anticancer and protonophric agent. STAT3 inhibitor. ab120951 Nifuroxazide Ç 100mg >98% JAK/STAT signaling inhibitor. Nitrofuran antibiotic. ab141373 NVP-BSK805 Ç 10mg 50mg >95% Selective JAK2 inhibitor ab120952 Stattic Ç 10mg 50mg >99% Selective STAT3 inhibitor ab141374 TG101209 Ç 10mg 50mg >95% Potent, selective JAK2 inhibitor. Flt3 and RET inhibitor. ab141377 TG-101348 Ç 10mg 50mg >95% Potent, selective JAK2 inhibitor ab141376 TG-46 Ç 1mg 5mg >95% JAK2 inhibitor ab141375 TG-89 Ç 1mg 5mg >95% JAK2 inhibitor

Signal transduction: MAPK

Cat No. Product Pack Sizes Purity Description ab120495 Anisomycin 10mg 50mg >98% Protein synthesis inhibitor ab141343 AZD6244 Ç 10mg 50mg >95% Novel, potent and selective MEK1/2 inhibitor ab120640 BI-D1870 Ç 10mg 50mg >98% Ribosomal S6 kinase (RSK) inhibitor ab120365 CGP 57380 1mg 10mg 50mg >98% MNK inhibitor ab141348 CI-1040 Ç 10mg 50mg >95% ATP non-competitive MEK1/2 inhibitor ab120716 (-)-Epigallocatechin Gallate Ç É 1mg 50mg >98% Potent anti-oxidant flavonoid ab120863 Hydralazine hydrochloride Ç 1g >99% DNA methylation inhibitor. Anti-hypertensive agent ab120710 Isoprenaline hydrochloride Ç É 100mg >99% Non selective β-adrenoceptor agonist ab120653 2-Methoxyestradiol Ç 10mg 50mg >98% Potent antitumor and antiangiogenic agent ab120721 Myricetin Ç 5mg 25mg >97% Potent anti-neoplastic, anti-oxidant and anti-inflammatory agent ab120639 PD 0325901 Ç 10mg 50mg >99% Potent MEK 1 and 2 inhibitor ab120234 PD 98059 1mg 10mg 50mg >99% MEK1 inhibitor ab141362 PLX4720 Ç 10mg 50mg >95% Potent, selective mutant B-RafV600E and c-Raf-1Y340D/Y341D inhibitor ab141366 S-99 Ç 1mg 5mg >95% ASK inhibitor ab120638 SB 202190 Ç 10mg 50mg >99% Highly selective, potent, cell permeable p38 MAP kinase inhibitor ab120162 SB 203580 1mg 10mg 50mg >99% p38 MAP kinase inhibitor ab120235 SB 203580 hydrochloride É 10mg >99% p38 MAP kinase inhibitor; water soluble ab120836 SD 169 Ç 10mg 50mg >99% Potent, selective and ATP competitive p38α MAPK inhibitor ab120082 SL 327 1mg 10mg 25mg >99% MEK inhibitor ab120746 Sodium salicylate Ç É 5g >99% Cell permeable anti-inflammatory agent ab120065 SP600125 10mg 50mg >98% JNK inhibitor ab120650 Sulindac sulfide Ç 5mg 25mg >98% Active metabolite of Sulindac. COX-1/ 2 inhibitor. ab120989 TAK 715 Ç 10mg 50mg >99% Potent p38 MAPK inhibitor ab120835 TCS JNK 5a Ç 10mg 50mg >99% Selective JNK2/3 inhibitor ab120241 U0126 5mg 25mg >98% Selective MKK inhibitor ab120428 ZM 336372 1mg 10mg 50mg >98% Potent, selective c-Raf inhibitor

Signal transduction: Nitric oxide & oxidative stress

Cat No. Product Pack Sizes Purity Description ab120165 1400W É 10mg 50mg >99% Selective iNOS inhibitor ab120123 Aminoguanidine hydrochloride É 100mg >98% NOS inhibitor ab120750 L-Arginine Ç É 100mg >99% Precursor to nitric oxide synthesis ab120976 Bisdemethoxycurcumin Ç 5mg 25mg >98% Apoptotic anti-cancer, anti-inflammatory and anti-oxidant curcuminoid ab120973 Chlorogenic acid hemihydrate Ç 250mg 1g >99% Antioxidant with a variety of biological effects ab141119 Epicatechin Ç 1mg 5mg >99% Flavonoid with multiple biological effects ab120653 2-Methoxyestradiol Ç 10mg 50mg >98% Potent antitumor and antiangiogenic agent ab120661 Minocycline hydrochloride Ç É 50mg >99% Antibiotic. Demonstrates multiple effects. ab120137 NG-Monomethyl-L-arginine, monoacetate salt (L-NMMA) É 10mg 50mg >99% NOS inhibitor ab120721 Myricetin Ç 5mg 25mg >97% Potent anti-neoplastic, anti-oxidant and anti-inflammatory agent ab120958 (±)-Naringenin Ç 50mg 100mg >98% Citrus flavonoid. Antioxidant, anti-inflammatory. Ç ab120864 Nicotinamide 100mg 1g >99% Amide form of vitamin B3 ab120233 7-Nitroindazole 50mg >98% NOS inhibitor

Refer to page 3 for symbol key 40 Discover more at www.abcam.com/biochemicals Catalog Update01 - International_Update 31/01/2013 08:18 Page 41

Signal transduction: Nitric oxide & oxidative stress

Cat No. Product Pack Sizes Purity Description ab120136 Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) É 100mg >98% NOS inhibitor ab120285 S-Nitrosoglutathione (SNOG) É 10mg 50mg NO donor ab141393 Oxidized Glutathione (GSSG) Ç 1g >95% Hydrogen acceptor in determination of NADP and NADPH ab141406 PDTC (Ammonium pyrrolidinedithiocarbamate) Ç 100mg >98% Selective NF-κB inhibitor; antioxidant ab120726 Resveratrol Ç 100mg 500mg >99% Antioxidant polyphenol with a multitude of biological activities ab120014 SNAP 10mg 50mg NO donor ab120057 Spermidine hydrochloride É 100mg >99% Endogenous polyamine. nNOS inhibitor. ab120747 Trolox Ç 500mg >98% Antioxidant vitamin E derivative

Signal transduction: PI3K/Akt

Cat No. Product Pack Sizes Purity Description ab141337 Akt-I-12 Ç 1mg 5mg >95% Selective, reversible Akt inhibitor ab141070 Alsterpaullone Ç 1mg >99% Potent cyclin-dependent kinase (CDK) and GSK-3β inhibitor ab120898 AS-041164 Ç 5mg 25mg >98% Potent and selective PI3Kγ inhibitor ab120929 AS-252424 Ç 5mg 10mg >95% Potent and selective PI3Kγ inhibitor ab120935 AS-604850 Ç 5mg 25mg >98% Selective, ATP-competitive PI3Kγ inhibitor ab120928 AS-605240 Ç 10mg 50mg >98% Potent and selective PI3Kγ inhibitor ab120891 BIO Ç 10mg 25mg >98% Potent, selective, reversible GSK3 inhibitor; cell-permeable ab120967 Cantharidin Ç 25mg 100mg >98% Protein phosphatases 1 and 2A (PP1, PP2A) inhibitor ab120930 CAY10505 Ç 10mg 50mg >98% Potent PI3Kγ and casein kinase 2 inhibitor ab120903 CAY10626 Ç 1mg 5mg >98% Potent PI3Kα/mTOR inhibitor ab120890 CHIR99021 Ç 1mg 5mg >98% Potent, highly selective GSK3 inhibitor ab120964 Crosstide Ç 1mg >98% Akt peptide substrate ab120965 Crosstide (biotinylated) Ç 1mg >98% Akt peptide substrate, biotinylated ab120941 (-)-Deguelin Ç 10mg 50mg >98% Akt inhibitor. Anti-cancer agent. ab120884 3,5-dimethyl PIT-1 Ç 5mg 25mg >98% PIP3/protein binding inhibitor ab141352 GDC-0941 Ç 10mg 50mg >95% Potent, non-selective PI3K inhibitor ab141355 IC87114 Ç 10mg 50mg >95% Selective PI3Kδ inhibitor. Cell-permeable. ab120960 Indirubin Ç 5mg 25mg >98% Potent cyclin-dependent kinase and GSK-3β inhibitor ab141014 IPA 3 Ç 10mg 50mg >97% Group I, p21-activated kinase (PAK) inhibitor ab141168 Isobavachalcone Ç 1mg >99% Akt inhibitor. Natural chalcone. ab120966 L803 Ç 1mg >99% Phosphopeptide GSK-3 inhibitor ab120243 LY 294002 5mg 25mg >99% PI3-kinase inhibitor ab120956 LY 303511 dihydrochloride Ç 5mg >98% Negative control for LY 294002 (ab120243) ab120882 NVP-BEZ235 Ç 25mg 100mg >98% Potent ATP-competitive PI3K and mTOR inhibitor ab120375 Okadaic acid 25μg 100μg >98% PP1 and PP2A inhibitor ab141361 PI 103 Ç 10mg 50mg >95% Novel, potent, ATP-competitive PI3K, mTOR and DNA-PK inhibitor ab120931 PIK-75 Ç 5mg 25mg >98% Selective p110α PI3K inhibitor ab120885 PIT-1 Ç 10mg 50mg >98% PIP3/protein binding inhibitor ab141405 PP242 Ç 1mg >98% Potent and selective mTOR inhibitor ab120802 SC-66 Ç 10mg 50mg >99% Allosteric Akt inhibitor ab120924 TGX-221 Ç 100μg 500μg >98% Potent, selective PI3K inhibitor ab120936 Triciribine Ç 1mg 5mg >98% Selective, potent inhibitor of Akt activation ab120148 Wortmannin 1mg 5mg >98% PI3-kinase inhibitor

Signal transduction: Wnt signaling

Cat No. Product Pack Sizes Purity Description ab120976 Bisdemethoxycurcumin Ç 5mg 25mg >98% Apoptotic anti-cancer, anti-inflammatory and anti-oxidant curcuminoid ab120985 PF 670462 Ç 10mg 50mg >99% Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor ab120897 XAV939 Ç 10mg 25mg >98% Potent tankyrase inhibitor. Inhibitor of Wnt/β-catenin signaling.

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High quality in-house biological testing

In response to your feedback, we’re adding more data to our products through in-house and customer testing.

Used our products? – Let us know and you may be eligible for a free product of your choice using Abreviews.

Our biological testing includes: Western Blotting Competitive and selective anandamide transport inhibitor

SH-SY5Y cells treated with varied concentrations of AM404 (ab120095) causing increased expression of c-Fos.

Immunofluorescence 0 µM 1 µM 0 µM 1 µM Rosiglitazone (ab120762) - Selective PPARγ agonist

HeLa cells treated with rosiglitazone (ab120762) and staining for glucocorticoid receptor (ab3580, green) by ICC/IF.

Pharmacological testing Iberiotoxin (ab120379) - Selective blocker of the high-conductance, Ca2+-activated K+ channel

HEK293 cells plated for 48 hours and then transfected with rat Slo27 for 24 h.

20 mV 100 -80 mV (1) 80 (1) control 60

5 nA 40 % inhibition (3) IbTx 300 pM 200 ms 20 (2) 0 1E-11 1E-10 1E-9 1E-8 Log [IbTx] (M)

More biological test data will be available across the whole Abcam Biochemicals range soon.

42 Discover more at www.abcam.com/biochemicals Catalog Update01 - International_Update 31/01/2013 08:18 Page 43

How to order Abcam Biochemicals

What information do you require for my order?

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