UNC Linebergercan Comprehensivecer Cancer Center LinesUniversity of North Carolina School of Medicine & UNC Health Care Fall 2001 Childhood Cancer: UNC Treats the Whole Family Childhood cancer is complicated. First, it’s rare—only about 130 in a million chil- dren will be diagnosed annually in the U.S. Director’s Second, treatment often cures the initial Message cancer—about 75 percent—but also can 2 result in complications later in life, includ- ing the rare development of second malig- nancies. Finally, more than any other can- cer, it involves the entire family and not just the patient. Despite its rarity and improvements in treatment and supportive care, childhood cancers are the second leading cause of death in children after accidents. The most common is leukemia, accounting for al- Mia Hamm most 30 percent of childhood cancers. Golf Classic The most common type of leukemia is Acute Lymphoblastic Leukemia (ALL), Pediatric Oncology Team. Front row (left-right): Dr. Rupa Redding- 3 which accounts for about two-thirds of the leukemias. Lallinger; Linda Mansmann, oncology nurse; Dr. Julie Blatt, chief, of pedi- atric hematology-oncology; Dr. Stuart Gold; and Dr. Matt Richardson Rare As Truffles (fellow). Back Row (left-right): Mary Brookins, clinic nurse; Michael Musty, data manager; Dr. Brent Weston; Rose Dunaway, oncology nurse; Barbara “Common adult cancers are carcinomas, such as lung and Cheek; receptionist Khadijah Farrakahan, receptionist; Dr. Mike Douva colon cancers, and are very rare in childhood,” notes Brent (fellow); Dr. Paul Monahan; and Fran Wright, nurse practitioner. Not pic- Weston, associate professor of pediatrics in the Hematology/ tured are Dr. Herb Cooper; Kristi Geib, oncology nurse practitioner; Gwen Oncology Division. “In children, cancer is less toxin- or Konsler, oncology nurse; and Verity Kromah, clinic nurse. environment-related and more virus-related or hereditary. Because most pediatric tumors are tissue-specific rather than Stuart Gold, associate professor of pediatrics, is the organ-specific, they can be challenging to diagnose.” principal investigator for UNC to Children’s Oncology Group Profile: According to American Cancer Society statistics, about — the largest cooperative group in the world caring for child- Rivera/Calvo 8,600 children under the age of 15 in the United States will hood cancer. The group undertakes randomized clinical trial as 4 & Briefs be diagnosed with cancer this year. well as Phase I and II studies identifying new agents.“These “Because there are so few cases and fewer tumors, there trials incorporate laboratory/genetic research as well,” Gold has to be good coordination among cancer centers,” explains says. “We send in tumor tissue to a central bank for distri- Julie Blatt, professor and chief of the Pediatric Hematology/ bution to researchers looking into better treatments, the etiol- Oncology Division. “We do cooperative group trials which ogies of childhood cancers and the genetic basis of disease.” allow us to monitor types of treatments over time to deter- The group also initiates studies on supportive care, quality of mine which are most effective.” life and nursing. continued on page 3

Breast Cancer SPORE Renewed America’s Top Doctors WATCH A highly competitive national review by the National Cancer Program Institute awarded the Center a $12.5 million renewal of its 2001 List Published. 5 Specialized Program of Research Excellence (SPORE) in breast cancer with one of the best ratings in the history of the We’re extremely pleased Gifts to the SPORE program. Featured are projects using fundamental Center ’00-’01 & research to create novel therapies for advanced breast cancer that UNC had 53 doctors 6Clinical Trials and pioneering methods for genetically defining new sub- on this list in all specialties, types of breast cancer and their response to therapy. Ground- and particularly excited New breaking investigations into the disparities in incidence, Infusion mortality, and morbidity between African-American and that 19 of the 53 are Center Caucasian women will take on new dimensions as we follow 10 up outcomes in over 4,000 breast cancer cases. Full story in UNC Lineberger faculty. the next issue of Cancer Lines. the inside line up ... = Director’s its intellectual and humane Message treatment of patients, but not for its facilities. While this new infusion area will help, as will expanded clinic space for UNC Lineberger is designated a comprehensive cancer center by the women’s cancers in the new National Cancer Institute. Pediatric cancers throughout the cancer experience. A N.C. Women’s Hospital, these improve- tug at the very range of programs is available to patients, ments are only a stepping stone toward Cancer Lines is a semi-annual publication of the UNC Lineberger core of every- parents and siblings to make the time a new clinical cancer center. The UNC Comprehensive Cancer Center, one’s heart. A during treatment a little easier. We are Hospitals Board has authorized initial The University of North Carolina cancer diagnosis particularly grateful that UNC student planning for a new facility to better care School of Medicine at Chapel Hill. at any age is groups have organized programs to for our patients and families. Inciden- Dr. H. Shelton Earp, III, Director frightening, but complement the staff’s care. tally, we come into the 21st century with Dr. Joseph S.Pagano, Director Emeritus when a child is Others have come forward to support a new way to access care at UNC Line- Dianne G. Shaw, Director of Communications/Executive Editor diagnosed, it hurts pediatric oncology as well. Carolyn berger, a toll-free number to start the Margot Carmichael Lester, Editor us all a little Burnett is an example of a parent who process. Dial 1-866-828-0270, and more. And while wants to make a difference. After her patients, doctors or families will be ■ Please remove me from your Dr. Shelton Earp UNC Pediatric son, Edwin, was treated at UNC, she connected with program coordinators mailing list Oncology can’t worked tirelessly to expand Wilming- who can help. prevent children from getting cancer, ton’s highly successful “Chasing the Lastly, donors such as those who Name they can, in increasing instances, make it Horizon” fundraiser for Pediatric Oncol- developed “Chasing the Horizon” make ■ Please add the following to the go away. ogy. We salute her, and a whole host of so much possible: clinical care and re- Cancer Center’s mailing list. Even after a child has been treated Lineberger friends in Wilmington who search innovations that would not be and is back to a normal life, issues of took the time to plan and direct this possible without this help. This issue of Name long-term effects of therapy such as risk fabulous early spring event; we truly en- Cancer Lines recognizes our donor honor of a second cancer, insurance, employ- joyed seeing old friends and making new roll. This remarkable list continues to Address ability, fertility and other issues linger. ones during the festivities. grow, forcing us (joyfully) to expand City, State, Zip UNC is mindful of these issues and Treating cancer at any time is chal- Cancer Lines to add a two-page foldout. when possible treats each pediatric lenging to patients, their families and We thank each and every one of you UNC Lineberger patient with minimal dosing to achieve friends as well as the staff providing the who support the Center and its mission. Comprehensive Cancer Center maximum results. Our clinicians have care. That’s why we are delighted that Your confidence sustains our work and CB# 7295 created a clinic for long-term follow-up the new, spacious infusion area is now helps us move more swiftly towards the School of Medicine care of these brave young people. And open in the Clinical Cancer Center. This goal of eradicating this disease. University of North Carolina at fortunately this is one clinic population new unit triples the space we have to • Chapel Hill Chapel Hill, NC 27599-7295 — pediatric cancer survivors — that we care for our patients who receive chemo- (919) 966-3036 expect will continue to grow and therapy. The suite is a reality thanks to http://cancer.med.unc.edu flourish. the dedication and persistence of several UNC Pediatric Oncology treats the patients and their families who helped Printed on Recycled Paper patient, but works with the entire family articulate the need. UNC is known for

The open house and dedication of the new infusion area was held July 9 A plaque was made to “honor the courage and spirit of cancer patients and their families treated at UNC with special thanks to George Jefferson whose family helped make this new space a reality.” Patient advocacy catalyzed the remodeling process. Pictured (left to right): Dr. Beverly Mitchell, Center associate director; Marlene Rifkin, senior vice president, UNC Hospitals; Dr. Shelton Earp, Center director; Pat Decator, clinic head nurse; Mrs.Eileen Jefferson, wife of patient George Jeffer- son; Wendy McBride, clinic education coordinator; Kathy Guyette, director oncology services; Catherine Hogan, oncology nurse practitioner; Mary Beck, senior vice president for planning and program development, UNC Hospitals, and member UNC Breast Center Advisory Board.

2 cancerLines Fall 2001 UNC Treats the Whole Family continued from page 1 “UNC Has Given My Son Tricky Treatment According to the American Cancer Society, child- a Chance for Life” hood cancer mortality rates have declined 50 percent since 1973. Advances in treatment mean “Children are so resilient that it is hard to know when that roughly two-thirds of kids treated for one to they are sick, because they don’t act sick,” says Carolyn three years are cured. “In children, we’re often not Burnett. On a family trip, her two-year old son, Edwin, as worried about cancer recurrence as we are about developed bruises and red spots, but was acting fine. She the effects of treatment,” Blatt notes. Currently, a wasn’t worried until a trip to the park. “Edwin was com- national long-term study of 20,000 childhood ing down the little slide and when he rushed into my cancer survivors is underway to study these late arms and his face came to my chest, the little medallion effects.“We continue to look for treatments with I was wearing left its imprint in his forehead and I said, the same positive effects, but less toxicity.” ‘Oh dear, something is badly wrong here.’” Part of that means looking deeper into the bio- The next day, after a visit to his pediatrician, Edwin logy of each patient to determine courses of therapy. was rushed to UNC Hospitals with swelling organs and Carolyn Burnett and Dr. Stuart Gold pause for a a white blood count of 87,000. Stuart Gold, associate smile at the “Chasing the Horizon” fund-raising “There are biological features we understand at the event for UNC Lineberger Pediatric Program. molecular level about specific subgroups of patients professor in pediatrics and the Pediatric Oncology Divi- with ALL, for instance,” Weston says. “They have a sion’s outpatient clinic director, started treatment much higher risk for resistance to chemotherapy and immediately. may need more intense chemotherapy than a The Lineberger pediatric oncology team forms close patient with a lower risk of resistance.” ties with patients and their families, Burnett says. “Dr. But because children’s cells are still developing, Gold has not missed a Christmas working at that clinic treatments can do more than cure or mitigate the — he truly is an angel. The same can be said for Miss current cancer. “One of the largest challenges in Rose, Rose Dunaway. That wonderful lady has taken dealing with childhood cancer is remembering that Edwin’s blood every time we have gone to the clinic, you are working with a growing, developing child,” even coming on her day off. I have never seen such dedi- Gold says.“The younger the child, the more signifi- cation as I have from the members of that clinic!” cant may be the problems of growth, development Today, Edwin is doing much better. “He has tremen- and cognition,” Gold says. Depending on the disease dous hand/eye coordination,” says his mom.“His learn- and treatment, anywhere from 2-10 percent of ing abilities were not affected at all by the chemotherapy. children treated for pediatric cancers might develop He is having a bit of trouble walking because the meds secondary malignancies related to chemotherapy. have flattened his feet, but with physical therapy, he is “In pediatrics, we have a lot more time to deal getting better all the time.” Edwin, Carolyn and Grayson Burnett. with than medical oncologists because of secondary Shortly after Edwin’s treatments started, Nick and Lee malignancies, infertility and late effects.” Gold con- Garrett asked the Burnetts to speak at Chasing the Horizon, an annual event founded by Sanford Doxey tinues. For example, a child could be successfully and Louie Woodbury, Jr. to benefit the Cancer Center’s pediatric oncology program. treated for Hodgkins disease, then 5 to 10 years The Burnetts were initially reluctant about speaking, but had such a good experience, they spoke later develop AML related to the alkylating agent again the following year. “After all that the clinic has given me, how could I not do everything in my used to treat Hodgkins. Or a teenaged girl with power to help?” Burnett says. “They have given my son a chance for life.” Hodgkins in her chest would be predisposed to a Two years later, the Burnetts co-chaired the fundraiser with the Garretts and Richard and Barbara significant risk of breast cancer if she underwent Lund. The black-tie event had a Mardi Gras theme, complete with masks handmade by the children radiation therapy. of the clinic with help from the Carolina Pals, an organization that provides a buddy to each child in Longitudinal studies and off-therapy clinics have treatment.“Together the team created the masks and art work as a form of art therapy,” Burnett ex- helped pediatric oncologists develop new therapies plains. The art was then auctioned at the event along with basketballs signed by UNC players and or modify treatment regimens to reduce these after- prints by Betsey Fowler. All in all, the event raised more than $265,000 for the Cancer Center. effects. UNC runs off-therapy clinics in Wilmington “The thing about cancer,” Burnett has learned, “is that it does not discriminate. Cancer affects the and Raleigh for a variety of cancer and hematologic young as well as the old, any race—black, white, Indian. As the wonderful doctors at Chapel Hill say, patients.“We deal with the problems by identifying ‘We don’t know how or why cancer exists, all we can hope is to find a cure. And we will.’” new ones, screening for existing ones and educating our families about them,” Gold notes. All in the Family “We treat whole families, not just the children,” Mia Hamm Blatt says, “because the entire family is involved.” Most adults can be treated near home, but because of the rarity of pediatric oncology, most kids have Golf Classic to travel to regional medical centers for treatment. The Mia Hamm Foundation Golf Classic drew This means travel logistics, missing more school celebrity golfers to UNC’s Finley Golf Course for and parents having to miss work. The other sib- a good cause in April. The Foundation donated lings sometimes suffer from interruptions caused $30,000 to a fund at UNC Lineberger named in by the patient’s frequent medical visits. honor of Mia Hamm’s brother, Garrett J. Hamm, One particularly challenging aspect is how a who died in 1997 from complications related to a particular child deals with illness. “A five-year old bone marrow transplant. The funds will be used to might have a smoother or easier time of it than a help bone marrow transplant patients and their teenager, whose life is relatively well-formed and families in the post-transplant period with expenses gets interrupted by the process,” Weston notes. such as hotel stays and travel costs. Participants And this is on top of the traditionally frustrating included LPGA members, 1999 World Cup Soccer aspects of adolescence such as dating and body Champion players, UNC coaches, television sports image. celebrities, NFL, PGA and USA Hockey players. “Working with pediatric patients requires a Shown here at a reception prior to the event are: Mia multidisciplinary team,” Blatt says. “Social workers, Hamm and Dr. Tom Shea, director of the UNC Line- school teachers, transportation providers, psychol- berger Bone Marrow and Stem Cell Transplantation ogists — it’s a true team effort.”• Program.• cancerLines Fall 2001 3 on a national trial of fluorescent broncho- scopy, a technology used in early detec- ProfileProfile tion of lung cancer. “Lung cancer is one of the most lethal cancers,” she says. “More people will die of Cancer Physicians: it than breast, colon and prostate cancer combined. I saw an opportunity to look for A Family Affair better screening methods and develop Growing up, Patricia Rivera wanted to be a talk improved therapies and techniques to get show host. “I never envisioned a career in medi- better patient outcomes.” Today she’s the cine,” she laughs now. “But after taking some pulmonologist on the Lineberger multi- science classes in college, my genetics professor disciplinary lung cancer team, focusing on suggested I pursue a career in science because I screening and diagnosis. had a knack for it. It also,” she adds with a grin, Calvo, who says he never thought of “seemed like a more sustainable career.” anything other than medicine as a career, Her pursuit of a career in medicine not only looks at both surgical and biological factors Drs. M. Patricia Rivera and Ben Calvo pause a moment. Artwork landed her a stable career (she’s now an assistant in treating tumors. When he’s not in the operating on the door is by their three children; Benjamin, Alejandro & Sofia. professor of medicine at UNC, specializing in lung room, he’s investigating a group of cell receptors in cancer), but also led her to her husband, Ben the human growth factor family and their medicine and biology,” Calvo says. Rivera concurs. Calvo, associate professor of surgery at UNC. The expression in solid tumors. “I’m most proud of my family first, then my couple met while at Memorial Sloan-Kettering “During my surgery residency, I learned what career.” The couple has three children, ages 6, 5 Cancer Center. you can and can’t cure with operations,” he says. and 3. When Calvo was offered a position at Line- He was enthralled by biology and chemistry Though both parents are in medicine, Calvo berger in the surgical oncology program, Rivera (studying the latter in college) and never lost his says he has no intention of pushing his kids into wondered what she would do. Happily, she re- love of basic science even after deciding to be a sur- the field. “I’m still trying to figure out how I got calls,“UNC was trying to develop a multidiscipli- geon.“I was always thinking, what’s another way to into medicine,” he laughs. “All I know is that my nary lung cancer program and there was a need for treat cancer besides surgery‚ and wanted to pursue parents let us find our own way. The only direction a pulmonologist.” research and surgery in parallel. But there are few they gave was ‘Whatever you are, you gotta be institutions that have the gestalt to permit that to good at it.’ That’s what we’re telling our kids.” Specialties of the House happen. UNC is one of them.” • Rivera was working in the pulmonology division at Dedicated as they are to their professions, Rivera Sloan-Kettering when she had the chance to work and Calvo put family first. “There’s life outside of

berger’s director, “By not clear- clinically because drug companies have been clam- ing this material as rapidly as oring to know how the human body recognizes their you should, you end up de- drugs and marks them for degradation,” he says. veloping antibodies against “Our work provides the first close glimpse into how ‘self material‚’ that you that is accomplished. These results will further help BriefsBriefs shouldn’t have.” Some human us to identify and prevent dangerous drug-drug patients with retinitis pigmen- interactions in humans and to understand how drugs tosa have been shown to con- are metabolized and disposed of.” These results were tain mutations in the Mer gene published in Science. Mutation May Provide Key authors stated. There is also a possible link to the To Inflammation & Autoimmune autoimmune disorder systemic lupus erythe- Tumor Suppressor Activity A report in Nature from UNC scientists focused on matosus. “It’s very exciting to see a real physiologic New research reported in Science explains for the first the function of a gene called Mer, which is expressed function for this molecule emerge from research and time how an important tumor suppressor gene, p53, as a receptor on monocytes and macrophages, sca- to show it may be important in diseases of immune is activated in response to DNA damage to keep venger cells that circulate throughout the body or re- origin,” Earp says. cancer tumors in check. The gene normally monitors side in tissue and ingest dead tissue and degenerated biochemical signals indicating DNA damage or cells. Together with the genes Axl and Tyro3, Mer Key To Drug Metabolism Uncovered mutations associated with tumor development. comprises a family of molecules known as receptor Chemists at UNC and GlaxoSmithKline have When such signals occur, the p53 protein accum- tyrosine kinases, which serve multiple functions in succeeded in determining the structure of a key ulates in the cell nucleus where it can either program different tissues. Mer and Axl are found on cancer molecule, PXR, responsible for metabolizing more the cell to self-destruct or arrest its growth cycle. The cells. After further study, it appears that Mer is also an than 60 percent of drugs taken by humans. PXR is new study explains the molecular site of an all- important player in phagocytosis, the rapid clearance the master regulator of a protein called cytochrome important effect on p53 of phosphorylation. from tissue of dying, or apoptotic, cells. Without Mer, P450-3A, or CYP3A, that breaks the medications “In half of all tumor cells p53 is not working, macrophages apparently can still recognize and bind down. The molecule literally turns on and off the sometimes because a kinase gene responsible for p53 apoptotic cells but cannot ingest them. metabolism of half of all drugs used, and is critically phosphorylation is mutated,” explains Yue Xiong, “So the signal to ingest is missing due to the important to human health. Deadly examples of associate professor, biochemistry and biophysics and deletion of the receptor’s cytoplasmic tail,” explains interactions mediated by PXR include the break- Lineberger member. “When that gene is broken, Glenn Matsushima, a molecular neuroimmunologist down of the immunosuppressant cyclosporin and DNA damage cannot be repaired because p53 is at the UNC Neuroscience Center. “And because of the anti-HIV drug Indinavir. continually exported to the cytoplasm and getting this inability to quickly clear apoptotic cells, the cells “Using the crystal structure of PXR, we may be degraded there. So one could imagine if we were to eventually degenerate, releasing their internal com- able to predict these effects and possibly prevent develop a compound to block p53 export, we might ponents.” The consequences can eventually play out such drug-drug interactions,” says Matthew Redinbo, be able to restore p53 function in tumor cells with as an autoimmune response. The body sees this assistant professor of chemistry at UNC and a mutated kinase genes. We could give the compound spilled material from its own cells as foreign and member of the Lineberger Comprehensive Cancer to patients to wake up the p53 or prevent its makes antibodies to it. Adds Shelton Earp, Line- Center. “This work is likely to become important degradation. By continuing this line of research we

4 cancerLines Fall 2000 Preaching Prevention: Churches and Scientists Partner to Increase Cancer Screening and Health Behaviors Despite a decline in the overall incidence of colorec- motion is seen as serving God as well as taking care tal cancer over the last 20 years, statistics show that of oneself. “Working in partnership with churches, the rate of new cases among the African- health promotion efforts can be pro- American community actually increased moted and sustained by incorporating the 9 percent. Studies have shown that at natural assets of the social, organizational least part of the reason for this disparity is and religious aspects of the church into lifestyle — diet and exercise — and the behavior change programs.” lack of early detection. That’s a powerful way to motivate This prompted Marci Campbell, people to eat more fruits and vegetables, professor of nutrition and leader of lower dietary fat, exercise more and Lineberger’s cancer prevention and undergo cancer screenings. control program, to launch Wellness for The initial study will compare two African-Americans Through Churches (WATCH), a pro- main interventions: tailored education (TEd) in- gram that involves the religious community in pro- cludes personalized computer-tailored newsletters moting healthier lifestyles and cancer screening. The and videotapes, and lay health advisors (LHAs). TEd pilot study was deployed in 12 North Carolina materials included a message from the participant’s churches. pastor, community re- “The Black church is the center for many reli- sources, testimonials and gious, cultural and social activities,” Campbell ex- used Biblical passages to Pastor Joseph L. Ratliff of Shiloh Baptist Church in plains. “Many include the health of their members enhance cultural rele- Henderson, NC, is one of the twelve pastors whose churches and the community in their missions. Pastors and vance and motivation for worked with the WATCH study. The goals of the study: to church leaders are highly credible role models and change. The videotape, eat more fruits and vegetables and less fat, get regular persuaders in encouraging healthy behaviors through Screening for Health, exercise, and to be checked regularly for colon cancer, were ones the pastors all endorsed for the members of their sermons, organized activities and by personal ex- Screening for Life, won church. Each of the pastors involved in the project provided ample.” In addition, the Bible and scripture advise the Silver Medal in the the support from within the church that made the project people that “the body is a temple” and health pro- Public Health category successful. Below is an excerpt from a message sent by at the Houston International Worldfest film festival Pastor Ratliff to his congregation. in 2000. The lay health advisors were trained using a Nutrition manual and a series of bi-monthly sessions regarding “Do you not know that your body is a temple hope to understand exactly how the phosphate health behaviors, how to support members’ efforts to of the Holy Spirit, who is in you, whom you have signal shuts the door on p53 export. That knowledge change, and health activity planning. LHAs were received from God? You are not your own; can be used to develop a targeted treatment for required to hold at least one church-wide activity you were bought at a price. Therefore honor God malignant tumors.” focused on each behavior in the study (diet, physical with your body.” I Corinthians 6:19 (NIV) activity, screening). Initiatives included starting In this passage, it is clear that God expects our Predictive Genetic Testing Reviewed walking/exercise groups, having healthy choices at best when it comes to taking care of these wonderful “Predictive genetic testing is still very much in its church events, and inviting local physicians to speak bodies He has given us. One way of taking care of our infancy,” asserts cancer geneticist Jim Evans of the at worship services about the problem of colorectal body temples is to eat more fruits and vegetables, UNC’s School of Medicine and Lineberger Com- cancer in the African which gives us more fiber and helps protect us from prehensive Cancer Center. “It needs to be tailored American community many diseases and health problems. to the disease one is trying to predict and to the and the importance of It is not always easy to eat the way we should since individual and their family.” Evans, UNC colleague screening. we all lead lives with busy schedules and respon- Cecile Skrzynia and Wylie Burke of the University of The results of the sibilities. But when we look at the price that was paid Washington published a paper on the subject in the interventions are con- for us on Calvary, we should not have a problem with British Medical Journal. stantly reviewed and honoring God with healthy bodies by obeying His “Predictive genetic testing has a profound participants are sur- word. impact on additional people besides your patient,” veyed at baseline and Evans notes.“It invariably tells you important things after one year of partici- about family members who may or may not be pation. In addition, focus groups and church leader Cancer Prevention interested in that information, but who nevertheless surveys assess qualitative changes. “WATCH evalua- “...I have learned to be content whatever the could be impacted profoundly by that information. tion data are showing that the project was a success; circumstances.” Philippians 4:11 (NIV) There are diseases for which it makes tremendous participants increased fruit and vegetable con- When it comes to cancer, people have many sense. And all the way down on the far end of the sumption, physical activity, and colorectal cancer types of reactions. One way we can be content is to spectrum are genetic tests that offer very little screening using fecal occult blood test- have regular check ups and ask our besides harm to patients.” One example of a disease ing,” Campbell notes. “All these differ- doctors questions about any concerns for which genetic testing is highly useful is multiple ences were significant compared to the that we may have concerning getting endocrine neoplasia type 2, a rare disorder leading control churches.” The program is now tested for cancer. to thyroid cancer. Identifying those with this dis- being extended to churches in the Some people think that if they ignore order makes preventive surgery an option. On the control group. “We also recently applied symptoms or don’t ask questions, then other hand, Alzheimer’s disease illustrates the for a new American Cancer Society grant they don’t have to worry or be potential for predictive genetic testing to cause to extend the WATCH model to include concerned. Nothing is further from the harm. A positive test is an imprecise measure of risk breast and prostate cancer screening, also truth! That is called living in denial. If we and could result in anxiety, social stigma or very important for the African-American have the necessary tests, we can know discrimination.• population.” the truth and be content.•

cancerLines Fall 2000 5 Gifts to the

This list includes gifts and pledge payments to the Mr. and Mrs.Verner E. Stanley, Jr. Community Foundation of Gaston The Honorable Jeanette W. Hyde Dr. Joseph S. Pagano Mr. and Mrs. James R. Strickland, Jr. County, Inc. and Mr. Wallace N. Hyde Mr. and Mrs. H. William Palmer UNC Lineberger Comprehensive Cancer Center between Mrs. Frances H. Supper* Community Foundation of Greater IBM - MG Mr. John W. Peddycord July1,2000 and June 30,2001.The list doesn’t include the The Tomorrow Foundation Inc. Greensboro, Inc. Mr. and Mrs. David A. Irvin Mr. and Mrs. Benjamin Perlmutter many generous pledges also received. We have adopted Mr. and Mrs. C. Heide Trask, Jr. Community Foundation of Western Mrs. Helen B. Jenrette Phillip Morris Triangle Community Foundation, North Carolina, Inc. Mr. and Mrs. Raymond E. Jernigan Mr. and Mrs.William Parker Pope this policy in order to better conform with those of the Inc. Mr. and Mrs. Howard B. Cone Mr. and Mrs. Earl Johnson Mr. and Mrs. E.K. Powe greater University of North Carolina at Chapel Hill. The Wachovia Foundation, Inc. Cumberland Community Mr. and Mrs. Richard M. Johnson PPD Development Inc. Your gifts support and enrich the Center’s many Dr. and Mrs. James D. Yopp, Jr. Foundation, Inc. Ms. Evelyn M. Jordan The Honorable* and Mrs. L. Zeta Tau Alpha Foundation, Inc. Mr. and Mrs. Neill A. Currie Mr. and Mrs. Joseph Jordan, Jr. Richardson Preyer cancer research, treatment, and prevention programs. We Harry L. Dalton Foundation, Inc. Dr. and Mrs. Richard M. Jordan Mr. and Mrs. Rich Preyer are grateful for the hope and trust expressed by these 1,000.00 to 4,999.99 Mr. and Mrs. R.P. Stephen Davis Dr. and Mrs. William S. Jordan, Jr., Ms. Caroline M. Punte individuals and organizations. We have made every effort Mr. Robert L. Davis, III M.D. Dr. and Mrs.William G. Quarles Dr. and Mrs William B. Abernethy, The Dickson Foundation Mr. William T. Joyner, Jr. Quintiles Transnational Corporation to ensure this list is accurate and complete. If you find Jr. an error, please let us know by calling (919) 966-5905 Mr. and Mrs. R.R. Allen, Jr. or writing to the Assistant Dean for Institutional Mr. and Mrs. Douglas E. Anderson Anonymous Advancement. Mrs. Florence B. Ansley Dr. and Mrs. Gerald W. Arney 5,000.00+ Mia Hamm Foundation Mr. and Mrs. William P. Aycock, II Mr. and Mrs. Edward H. Hardison Mr. and Mrs. Zack H. Bacon, Jr. *Denotes Deceased Ms. Sylvia R. Hatchell Mr. and Mrs. Richard P. Badham Mr. and Mrs. Edward Anderberg Mr. David R. Hayworth, Jr. Mrs. George Bagby Mr. and Mrs. Shepard B. Ansley Mr. and Mrs. Lee A. Henningsen Mr. and Mrs. Stephen L. Baldwin, Mr. and Mrs.William J. Armfield, IV Ms. Ethel K. Hurvitz Jr. Ms. Sonia G. Austrian International Equity Advisors LLC Mr. Thomas M. Barnhardt, III Estate of Lucius Pender Best Dr. I.A. Jaffe Barnhill Contracting Company Best Distributing Co. Dr. Samuel G. Jenkins, Jr. John D. Bassett, III, Foundation Big Rock Blue Marlin Tournament Mr. and Mrs. James C. Kennedy BB&T Mr. and Mrs. James C. Bivens Ms. Gloria Lapin Mr. and Mrs. F. James Becher The Breast Cancer Research Mrs. Elisabeth Lineberger and Dr. Ms. Eleanor M. Best Foundation Peter Lyon Mr. and Mrs.William F. Black Mrs. Christie Brinkley Mr. and Mrs. Joseph W. Lineberger Mr. and Mrs. George S. Bristol-Myers Squibb Mr. and Mrs. Henry E. Longley Blackwelder, Jr. J.W. Burress Foundation The A.W. McAlister Foundation, Inc. Mr. and Mrs. Judson H. Blount, Jr. Cancer Research Foundation of The Medical Foundation of North Blue Cross Blue Shield of N.C. America Carolina, Inc. The Blumenthal Foundation Capital Community Foundation Inc. MedImmune, Inc. Mr. and Mrs. William L. Boddie Carolina Builders Corporation Mrs. Louise B. Miller The Nickolas Bunn Boddie, Sr. & Mr. and Mrs. George H. V. Cecil Ms. Elizabeth H. Mitchell Lucy Mayo Boddie Foundation The CEMALA Foundation, Inc. North Carolina Community Ms. Joan P. Boone Chapel Hill Breast Cancer Research NCCU held its annual “Walk for the Cure” and raised $1000 for the UNC Lineberger Breast Foundation Mr. and Mrs. Charles N. Briley Cancer program. Some of the participants included back row (left to right): Michelle Gray; Foundation Ms. Lynn M. Packard Mr. and Mrs. Harry M. Bryant, Sr. Mr. and Mrs. Herman Cone, Jr. Park Foundation Mr. and Mrs. D.W. Bumgardner, Jr. Kisha Adams; Darritta Edwards; Sonja Matheny; and Merrily Neill. Front (left to right): Mr. and Mrs. Herman Cone, III Mr. and Mrs. Hugh P. Perry Jacob Burns Foundation, Inc. Michele Taylor; Sonya Scott; and Patrice Hargrove. Mr. and Mrs. Peter D. Cosgrove Mr. and Mrs. Allen W. Post, Jr. Mr. and Mrs. John W. Burress, III Delta Delta Delta – UNC Mr. and Mrs.W. Trent Ragland Mr. Samuel M. Byrd Mrs. Virginia Pou Doughton Mr. and Mrs. Clarence H. Keller Rabbit’s Crossing Properties, Inc. Mr. and Mrs. James F. Downey The Reveas Foundation Cape Fear Memorial Hospital, Inc. Dowd Foundation, Inc. The Kent Foundation W. Trent Ragland, Jr. Family Mr. and Mrs.Christopher R. Elliott The Robertson Foundation Mr. and Mrs. George Watts Carr, III Mrs. Nancy S. Dowdy Mr. and Mrs. Alexander Kosma Foundation A.E. Finley Foundation, Inc. Mr. and Mrs. James Ross Mr. and Mrs. Joseph M. Carstarphen Mr. and Mrs. Sanford Doxey, Jr. KPMG Foundation Mr. and Mrs.Walter D. Ramberg Foundation for the Carolinas Ms. Jean L. Sajor* Causey Foundation Drs. H. Shelton Earp, III and Joanne Ms. Shirley N. Lathrop Mr. William G. Rand Genentech, Inc. Mr. and Mrs. Sol Schechter Ms. Estelle B. Cheek Earp Liberty Healthcare Services Mr. W.T. Roberts, Jr. and Mrs. Louise Mr. and Mrs. Richard Godosky Mrs. Jo C. Smith Mr. and Mrs.William G. Clark, III Edwin Hunter and Associates, Inc. Liberty Home Care, LLC L. Roberts Mary Louise Riddick Gregory W. A. Smith Trust Mr. and Mrs. James E. Clement, Jr. Mr. and Mrs. Robert A. Emken, Sr. Mr. and Mrs. George Walter Mr. and Mrs. Phil Rominger Charitable Remainder Trust Southeastern Brain Tumor Dr. and Mrs. Robert S. Cline Environmental Specialties, Inc. Loewenbaum Mr. Glenn A. Rose Mrs. Janie D. Griffin Foundation Mrs. Jane L. Cochrane Etc., Inc. Mr. Peter J. Long Ms. and Dr. Carolyn N. Rudnick Mrs. Rochelle T. Grubb Felix Harvey Foundation Mr. Richard B. Lupton Mr. Thomas Ruffin, Jr. Mr. and Mrs. Purvis J. Ferree, Jr. M. Haley Foundation, Inc. Salisbury Community Foundation, Mr. and Mrs. Victor Finalborgo, Jr. John and Carolyn Maness Inc. Mr. and Mrs. Edward S. Finley, Jr. Foundation Mr. and Mrs. Bennett B. Sapp Mr. and Mrs. Robert W. Foster Mrs. Betty H. Marsh The Schwab Fund for Charitable Mr. John H. Fox Mr. and Mrs. James H. Martin, Jr. Giving John Harper Fox Foundation Mr. and Mrs. Robert E. Mason, III Second Impressioins Consignment Nick Garrett Development, Inc. Mr. and Mrs. Henry H. Massey, Jr. Warehouse Mr. Milton Lee Garrison Mr. and Mrs. J. Louis Maxwell, Jr. Signature Outdoor Advertising GlaxoSmithKline Mr. and Mrs. Roland P. Company Mr. Dale Goldman McClamroch, Jr. Mr. and Mrs. John M. Silverstein Mr. and Mrs. George D. Gornto Mr. Samuel A. McConkey Mr. and Mrs.William A. Simpson Governors Club Foundation, Inc. Mr. and Mrs. Robert H. McInnis Mr. and Mrs. Steven D. Skolsky Grady-White Boats, Inc. Dr. and Mrs. William W. McLendon Mrs. Gertraud T. Smith Mr. and Mrs. S. Page Graham Mr. Dalton L. McMichael, Sr. Mr. and Mrs. James M. Smith Mr. and Mrs. Isaac B. Grainger, Jr. J. A. McNeill and Son, Inc. Ms. Joan S. Snyder Mr. William R. Grant Mr. and Mrs. Ronald B. McNeill Mr. Edwin M. Speas and Ms. Debra Mr. and Mrs. Lawton D. Gresham Mr. Hugh McRae, III W. S t ewart Mr. and Mrs. Joseph W. Grier, Jr. Merrill Lynch Sprint Mrs. Margaret O. Gulley Mr. Steve H. Millender Mr. and Mrs. Joseph W. Stanley Mr. and Mrs. Walter V. Hall Mr. and Mrs.Thomas D. Mincher Mr. and Mrs.Thomas I. Storrs Dr. and Mrs. G. Denman Mr. and Mrs.W. Paul Monroe Dr. Williamson B. Strum Hammond Mr. and Mrs. Benjamin E. Moore, Jr. Mr. and Mrs. William H. Taft, Jr. Mr. and Mrs. C. Rush Hamrick, Jr. Mr. and Mrs. Raymond C. Moore Dr. and Mrs. Luther M. Talbert Mr. R.P. Hanes, Jr. Mr. and Mrs. George M. Moorefield, Mr. and Mrs. Norwood A. Thomas, Mr. and Mrs. Larry W. Harris II Jr. Mr. and Mrs. Cecil W. Harrison, Jr. J.P. Morgan & Company Timberlake Foundation Carolina Cancer Focus, the UNC campus group that raises awareness of and funds for cancer, Mr. Jessie S. Hasler Neisler Foundation, Inc. Time Warner Cable held a 3-on-3 basketball tournament in April in Woollen Gym. Close to $1000 was raised for Mr. James T. Hedrick, Sr. The Eleanor & Roy Nester Family Toleo Foundation UNC Lineberger. Pictured are CCF event organizers, officers, and some team members. Front row: Mr. and Mrs. A. B. Henley. III Foundation Mrs. Anne B. Tomlinson Mr. William S. Henry Mr. and Mrs. Peter J. Nikonovich Mr. and Mrs. Lawrence A. (left-right): Jon Holmes; Alex Barnes; Erica Simon; Shelley Koon; and Lisa Wald, CCF president. Mr. and Mrs. Edwin A. Hubbard O. H. Rankin Foundation Tomlinson, Jr. Back row: Eric Johnson, CCF founder; UNC men’s varsity basketball team members Will Johnson Mr. and Mrs. Thomas W. Hudson, Dr. and Mrs. Michael S. O’Malley Triangle United Way and (now former team member) Joseph Forte; Paymon Rouhanifard; Robert Albright; Arash Jr. Mr. and Mrs. Donald F. Orr Trimeris, Inc. Jahanian; and Michael Abel. Mr. and Mrs. John C. Huffard Mr. and Mrs. William H. Page

6 cancerLines Fall 2001 Center ’00-’01

Mr. and Mrs. Richard A. Urquhart, Mr. James T. Hedrick, Jr. Mr. Andrew J. Angelo Jr. Mrs. Marian H. Hicks Ms. Martha Atwater Mrs. Patsy Uzzle Mr. Henry H. Hildreth, Jr. Dr. and Mrs. Joseph W. Baggett Mr. and Mrs. Stuart F. Vaughn Mr. and Mrs. Robin L. Hinson Mr. and Mrs. Sheldon Balbirer Wachovia Bank and Trust Company Mr. and Mrs. Samuel W. Johnson Ms. Anne J. Batten Ms. Elizabeth C. Walker Mr. and Mrs. Gerald C. Kitch Bell Family Foundation Mr. and Mrs. Walter L.Ward Dr. C.M. Kuzmiak Mr. and Mrs. John L. Benson Mr. and Mrs. Charles L.Weill, Jr. Mr. and Mrs. Arnold Lakey Mr. and Mrs. George Breslow Mr. and Mrs. Edward I.Weisiger Ms. Lynda M. Lennon Brewer Foundation, Inc. Mr. and Mrs. S. Montgomery White, Mr. and Mrs. Seymour M. Levin Mr. Louis A. Burney, Jr. Jr. Mr. and Mrs. L. Duane Long Cape Fear OB/GYN Mr. and Mrs. B.R. Williamson Mr. and Mrs. Michael E. McClure Cape Fear Pediatrics Mr. and Mrs. Murray Williams Albert and Nan Gray Monk Mr. and Mrs. James B. Carlisle Mr. and Mrs. Peter P. Williams, Sr. Foundation Carolina Industrial Resources Wilson Foundation Mr. and Mrs. William C. Munson, Jr. Mr. Michael A. Casey Mr. Lanny T. Wilson Mr. and Mrs. Gene Namkoong Mr. and Mrs. John A. Cates The Winston-Salem Foundation Mr. William F. Otto Chapel Hill Tennis Club Mrs. Edwina D. Woodbury and Mr. Dr. Joseph S. Pagano Mr. and Mrs. Marshall E. Clements Dennis M. McGill Dr. and Mrs. David R. Patterson Mr. Arthur R. Cogswell and Mrs. Mr. Louie E.Woodbury, Jr. Pharmacia & Upjohn Co. M. Saffo-Cogswell Wren Foundation Inc. Phi Beta Lambda, Inc. Mr. and Mrs. Thomas C. Coxe, III Mr. and Mrs. Robert L. Zucker Progressive Computer Systems, Inc. CrossRoads Ford Prudential Securities Mr. E.L. Daughtridge, Jr. 500.00 to 999.99 Ms. Myrtle J. Pruitt Mr. Richard Daves Airspeed Mr. and Mrs. Glenn D. Rayle Ms. Kirsten A. Deluca Mr. Zeb Alley Ms. Tula C. Robbins Mr. and Mrs. Ambrose B. Dudley Mr. and Mrs. Frank R. Anderson, Jr. Mr. W. Glenn Robbins Ms. Gretchen Durgin The Chapel Hill Tennis Club held a local celebrity tournament and silent auction and raised Mr. and Mrs. Paul B. Barringer Mr. E. N. Robinson Mr. and Mrs. Jeffrey W. Elliot $3200 for the Lineberger’s lung cancer program. (Left to right): Chapel Hill Tennis Club manager Mr. Bruce A. Biggs The Ralph S. Robinson Family Mr. and Mrs. Peter Epermanis and tournament organizer Jane Hamborsky; Lineberger director emeritus Joseph Pagano; UNC Mr. Lou U. Blackman Foundation Ms. Mary L. Ferri Mr. and Mrs. George Rountree, III Mr. and Mrs. Donald J. Fisher President Molly Broad; Tennis Club pro Michael “Z” Zaluski; and UNC Lineberger associate Mr. and Mrs. B. Mayo Boddie, Jr. director Bill Cance. Mr. and Mrs. Samuel L. Booke, Jr. Dr. Joseph H. Roycroft, Jr. Mr. Jay S. Fishman Burroughs Wellcome Fund Sealy, Inc. Drs. Peter H. Gilligan and M. Lynn Dr. and Mrs. Robert E. Sevier Smiley Mr. and Mrs. Timothy R. Calkins Mr. and Mrs. Frederick G. Kilgour Mr. and Mrs. Jack T. Wright Mr. and Mrs. Marvin K. Blount, Jr. Mr. and Mrs. Robert W. Smith Mr. David J. Goode Mr. and Mrs. A. Leon Capel, Jr. Kirby and Holt Foundation Mr. and Mrs. Robert T. Wyker Mr. and Mrs. David C. Blumenstein Mrs. G. T. Smith Mr. Karl D. Gottschalk and Ms. Carolina Brewery Mr. Charles N. Landen, Sr. Blythe Brothers Foundation Mr. Lee R. Smyre Dorothy Pugh Mr. and Mrs. Marvin J. Carver, III Mrs. E.H. Sayre Lineberger and Mr. 100.00 to 249.99 Mr. and Mrs. C.R. Bock Mr. Joseph A. Chiarello Sprint Foundation Mr. and Mrs. Thomas B. Grainger Mike Tribble Abbott Laboratories - MG Mr. and Mrs. Michael W. Boddie Mr. and Mrs. Charles E. Conner Dr. and Mrs. Brian C. Stabler Mr. Alfred W. Griffin, II Mr. and Mrs. George R. Little, Jr. Mr. and Mrs. Roger W. Ackerman Mr. and Mrs. Nick B. Boddie M.G. Crandall and Affiliates Mr. and Mrs. Richard E. Stewart Mr. Eugene W. Hackney Mr. and Mrs. Hugh D. Little Ms. Helen T. Adams Mrs. Mary M. Bode Mr. W. Lee Crouch, Jr. Mr. and Mrs. John Thomas Sullivan Mr. and Mrs. Charles C. Hargrave M&W Industries, Inc. Mr. and Mrs. Steven K. Akiyama Mr. and Mrs. A.W. Bohanan Mr. Daniel C. Deitz The Talbert Family Foundation Mr. and Mrs. Wade H. Hargrove Mr. and Mrs. G.C. Maxwell, Jr. Ms. Cherine M. Ali Mr. and Mrs. Douglas H. Boone Ms. Roberta G. Dillenburg Dr. and Mrs. Joshua Tayloe Mr. and Mrs. Thomas L. Harrington Mr. and Mrs. Ben Mayo, II Mrs. Emily H. Allen Boone, Hill, Allen and Ricks Mr. and Mrs. J. William Dinwiddie Uniquities, Inc. Ms. Carolyn M. Hatley Mr. and Mrs. Edward F. McCallum Mr. and Mrs. William R. Allen III Dr. and Mrs. Gary D. Bos Ms. Ruth E. Edwards Dr. and Mrs. George C. Venters Mr. and Mrs. Michael L. Hendren Mr. and Mrs. Carter M. McKaughan Mr. and Mrs. John G. Alley Mr. Thomas M. Bost Elevator Sales and Service, Inc. Mr. James E. Wallace Ms. Mary A. Hildreth Ms. Cynthia J. McNeill Mr. and Mrs. B.G. Anderson, Jr. Mr. and Mrs. Paul C. Box ePlus Technology of NC, Inc. Mr. William C. White Mr. and Mrs. Louis E. Hill Ms. Paula G. Meador Ms. Frances W. Anderson Col. William P. Boyd Dr. George W. Fisher Mr. and Mrs. James R. Williams Mr. John B. Hoffman Mr. and Mrs. R.M. Mincey Mr. and Mrs. James H. Anderson Ms. Mary-Dell Brady Ms. Jane L. Fouraker Wyrick, Robbins, Yates & Ponton Ms. Susan Hogan and Mr. Dominic Mr. and Mrs. George Mountcastle Mr. and Mrs. Mark W. Andersen Mr. and Mrs. F. Lanier Branson Mr. and Mrs. Ralph Gevinson Moore NUR America, Inc. Ms. Carolyn M. Armitage Mr. and Mrs. Scott Braswell Gregory Capital Management LTD 250.00 to 499.99 Mr. Christopher A. Holmes Mr. and Mrs. Stephen Oglesbee Dr. and Mrs. F. Walton Avery Ms. Doris R. Bray Mr. W. Clyde Griffin Advisor Charitable Gift Fund Mr. and Mrs. W.J. Host Pearson Education Publishing Mr. and Mrs.Walter Avery, Jr. Mr. and Mrs. Paul A. Bredenberg Mr. and Mrs. Frank B. Hanes, Jr. Aetna Life & Casualty Ms. Cynthia R. Johnson Company B&J Custom Printing Ms. Mary Briley Mr. and Mrs. Cyrus S. Hapgood, Jr. Ajinomoto USA, Inc. Ms. Louise C. Johnson Mr. Howard A. Penton, Jr. B.M.J. Sales Ms. Beth O. Briley Mr. and Mrs. Joseph E. Harley, III Mr. and Mrs. Richard C. Andrews, Dr. and Mrs. William R. Jordan Mr. Clifford B. Perry Mr. Leslie E. Babcock Mr. and Mrs. Leo Brody Mr. and Mrs. Theodore W. Hayes Sr. Just Looking, Inc. Mr. H.H. Phillips, Jr. Ms. Mary W. Baggett Mr. Bart Broome Mr. and Mrs. J. Dickson Phillips The Bailey Foundation Mr. Charles G. Brown Mr. and Mrs. Manfred K. Piper Mr. and Mrs. Charles R. Baker Mr. Billye J. Brown PPG Industries - MG Mr. and Mrs. Paul W. Baker Dr. and Mrs. David W. Brown Ms. Jane B. Preyer Ms. Roslyn H. Balbirer Ms. Ruby L. Brown Mr. and Mrs. Lewis S. Rathbun Ms. Roxy M. Barbee Mr. and Mrs. C.I. Bryan Mr. and Mrs. Keith F. Richardson Mr. and Mrs. Jeffrey T. Barber Bryant-Durham Electric Co., Inc. Mr. Philip T. Rodilosso Mr. Allan L. Barker Mr. G.R. Buchanan Mr. Peter B. Ruffin Mr. and Mrs. Robert L. Barker Dr. and Mrs. Paul L. Bunce Mr. Charles E. Ruffin, III Mr. and Mrs. Russel N. Barringer Mr. Joseph E. Bunn Mr. and Mrs. Allan Schroeder Mr. and Mrs.W.K. Barringer Mr. and Mrs. Kenneth H. Burnette Mr. and Mrs. Benjamin F. Seagle, Mr. and Mrs. Jacob M. Bass Mr. Louis A. Burney III Mr. and Mrs.William J. Bateman, Jr. Ms. M.E. Burns Mr. and Mrs.Ted B. Seagroves Dr. and Mrs. J. Nichols Beard Mr. and Mrs. William L. Burns, Jr. Drs. Thomas C. and Katherine M. Ms. Eve C. Beasley Business Systems & Consultants, Shea Ms. Michelle B. Beischer Inc. Ms. Elizabeth A. Silverstein Mr. and Mrs. Tim Belk Mr. and Mrs. John P. Calhoun Mr. Smethills Mr. Kenneth A. Bell Mr. and Mrs. David M. Callahan Mr. and Mrs. Tim Smith Dr. and Mrs. Vladimir B. Bensen Ms. Georgia B. Campion Mr. and Mrs. Carl L. Spears, III Mr. and Mrs. Saul Berenthal Mrs. Mary J. Carey Mr. A.D. Stallings Drs. Danilo R. and Imelda Bernardo Mrs. Lesta W. Carlo The Sack Family Charitable Fund Mr. and Mrs. Gerald W. Bernhoft Mr. and Mrs. Austin Carr Ms. Helene W. Thompson Mr. and Mrs. Richard H. Bierly Mr. and Mrs. J.D. Cartwright Mr. A.P. Thorpe, III Mr. and Mrs. William L. Bingham Col. and Mrs. Cecil Cayton Mr. Carl Turnage Mr. and Mrs. Robert F. Bird The CCB Foundation Mr. Frederick B.Tygart Mr. and Mrs. Denis Biron Central Carolina Bank and Trust Co. Ms. Carolyn Van Sant Mr. and Mrs. Nelson M. Bishop Centura Bank - MG Dr. and Mrs. Donald W. Varner Mr. William K. Bixby Mr. and Mrs. George H. Chadwick Ms. Susan J. Voskuil Mr. Robert C. Blades Mrs. Betsy I. Chamberlin Performance BMW held its annual Drive for the Cure, a fundraiser for the Susan G. Komen Breast Wachovia-MG Chancellor and Mrs. Julius L. Cancer Foundation, on May 19 with over 185 drivers and raising $4716.00 for breast cancer Dr. and Mrs. Robert A. Blake Ms. Kim Wait Mr. and Mrs. James R. Blalock Chambers research. This year’s local Hero was Lillie Atwater, a member of UNC Lineberger’s Breast Center Mr. and Mrs. D.E. Warren Mr. and Mrs. William Blanton, Jr. Mr. and Mrs. Henry F. Chancy Advisory Board and a volunteer with the Breast Imaging Program at UNC. (Left to right): Mark Mr. and Mrs. David P. Washburn Ms. Julie Blatt and Mr. Arthur Ms. Amy Chang Moore, general sales manager, Performance BMW; Jill Farrell, marketing manager; daughter Jo Mr. and Mrs. Ben F. Weaver Greenberg Mr. and Mrs. C.A. Charles Atwater; Lillie Atwater; daughter Donna Farrow; and Paulette Pauley, NC Triangle affiliate Komen Mr. and Mrs. Murray Williams Mr. Norman H. Blatt Ms. Mary Sue M. Cheek Mr. and Mrs. Ernest W. Williamson Mr. and Mrs. Andrew M. Chused representative. Mr. and Mrs. Franklin L. Block

cancerLines Fall 2001 7 Mr. and Mrs. David S. Clark Mr. and Mrs. Hugh M. Duncan C. Kenney Mr. Julian J. Clark, Jr. Dr. and Mrs. Noel Dunivant Lawrence J. Goldrich Foundation Dr. and Mrs. J. Edwin Clement Mr. Glenn D. Durham Ms. Vicki E. Goldrich Mr. and Mrs. George E. Clements Durham Orange New Car Dealer Mr. Bruce Goldstein Mr. and Mrs. Gilles Cloutier Association Mr. and Mrs. Steven J. Goldstein Mr. and Mrs. Laurence A. Cobb Mr. and Mrs. Ralph S. Eason Goldston’s Beach, Inc. Mr. Larry Coe Ms. Frances H. Eckel Mr. David B. Golub Mr. and Mrs. Joseph D. Coleman Mr. and Mrs. J.Wilbert Edgerton Ms. Pauline Gooch Mr. and Mrs. William F. Collins Mr. John A. Edgerton Mr. and Mrs. Raymond H. Mr. James E. Condon and Mrs. Ms. Martha B. Edmondson Goodmon, III Wendy Plump Ms. Peggy H. Edwards Mr. and Mrs. David R. Gorby Mr. and Mrs. Alan W. Cone Mr. W.A. Edwards Mr. John Grace Dr. and Mrs.William G. Conley, III Mr. and Mrs.W. Eugene Edwards Mr. James W. Grainger Mr. and Mrs. Roy W. Cook Mr. and Mrs. H. J. Elam, III Mr. and Mrs. S.C. Griffin Dr. William C. Cooper, Jr. Ms. Jean Elia Dr. and Mrs. Thomas H. Grote Corporate Imaging Systems, Inc. Mr. Jasper J. Elliot Dr. and Mrs. Larry D. Grubb Mr. and Mrs. Timothy W. Corrigan Mr. and Mrs. William B. Elliot Mrs. Blanche Gustin Coty, Inc. Ms. Cynthia S. Elliott Mr. and Mrs. Charles H. Hacker, Jr. Mrs. Hannah M. Cowell Mr. and Mrs. Patrick D. Engel Mr. and Mrs. Charles Hacker Mrs. Phyllis Cowell Mr. and Mrs. Melvin Ervin Mrs. Doris W. and Mr. Waldo E. Mr. and Mrs. Gerald P. Cox Mr. and Mrs. G. Marlin Evans Haisley Mr. and Mrs. E. Ragland Coxe Mr. Randy Evans Ms. Carolyn Y. Hall Mr. and Mrs. Alpo Crane Mr. and Mrs. Lee B. Farmer, III Clyde Hall Enterprises Inc. Mrs. Lisa Crawley Ms. Barbara Faulkner Ms. Jane Hamborsky Mr. and Mrs. J.Y. Creech Mr. Andrew Feldstein and Mrs. Jane Mr. Howard L. Hamrick, Jr. Mr. John Crosland, Jr. E. Vernon Mr. and Mrs. Franklin W. Hancock Mr. and Mrs. Robert W. Crumley Mr. and Mrs. J. Daniel Ferguson, Jr. Chancellor and Mrs. Paul Hardin UNC Breast Center nurse practitioner Judy Swasey (center) organized a women’s exercise group Mr. and Mrs.Walter Crump Ms. Janncey W. Ferrell Mr. and Mrs. Glenn Harding Ms. Jean C. Crutchfield Mr. George E. Findlay Mr. and Mrs. William T. Hardis for sedentary women with participation in the NC Triangle Komen Race for the Cure as a goal. Mr. and Mrs. Francis E. Dail Col. and Mrs. Walter M. Fitts Ms. Eleonora P. Harman More than 60 women between the ages of 22-82 took part in the Race including first-time runners Mr. and Mrs. Charles O. Dalton LCDR David L. Fogle Mr. and Mrs. John M. Harney and sisters (left) Stefanie and (right) Heidi Schmechel. The Friday Continuing Education Center Dr. Lucy C. Daniels Dr. and Mrs. P.G. Forsyth Mr. Boyd G. Harris made space available for weekly warm-up exercise sessions and parking. Thanks to South Square Mr. and Mrs. Carl M. Daughtry Mr. James E. Foscue Mr. William A. Harris Mall’s Lady Foot Locker for discounts on shoes and clothing. Mr.* and Mrs. M. Hollon Davenport Mr. James E. Foscue, Sr. Mr. Frank S. Harrison Billy Joe Davis Mr. and Mrs. Daniel W. Fotsch Dr. W. D. Harrison Mr. Lance Davis Dr. and Mrs. Wesley C. Fowler, Jr. Mr. and Mrs. Robert C. Harriss Ms. Catherine D. Holland General William D. Lackey Mr. James C. McNeill Ms. Anne S. Davis Ms. Elizabeth Browning Fox Mr. and Mrs. Henry D. Haywood Mrs. Nancy C. Hollingsworth Mr. and Mrs. H. K. Landis Mr. and Mrs. Gregory S. Meade Ms. Faye Davis Freedom Federal Credit Union Mr. and Mrs. Richard L. Heilman Mr. Robert W. Holmgren Mr. and Mrs. Kenneth A. Lang Mr. and Mrs. William E. Meador Mr. and Mrs. J.D. Davis Dr. Haiyan Fu Ms. Jo E. Heiss Mr. Dallas Holoman, Jr. Mr. and Mrs. Peter Lash Mr. Frank P. Meadows Mr. and Mrs. James M. Day Mr. and Mrs. W. Erwin Fuller, Jr. Dr. and Mrs. James L. Henderson Mr. and Mrs. Jack Holt Mr. Stephen M. Lastelic Dr. and Mrs. Robert Means Dee Shoring Company Mr. and Mrs. Peter J. Gaffney Dr. and Mrs. Donald L. Henson Mr. and Mrs. R.E. Holt Mr. Kenneth B. Lee Ms. Linda S. Mercer Mr. James E. Deegan Mr. and Mrs. Jeffrey M. Gallisdorfer Mr. William M. Herndon Mr. W. Clary Holt Mrs. Isabel J. Lehto Merck Company - MG Mr. and Mrs. Donald H. Denton, Jr. Mr. Alex Galloway, Jr. Mr. Billy T. Herndon Mr. and Ms. Walter L. Hood Mrs. C.T. Leinbach, Jr. Mr. and Mrs. Bernard C. Meredith Mr. William H. Hooks Mr. and Mrs. Richard Levin Merrill Lynch Mrs. Jeane M. Hornaday Mr. and Mrs. Albert Levine Mrs. Lucyle T. Merriwether Ms. Donna C. Howard Mr. Edward H. Lewis Mr. and Mrs. Bruce L. Miller Mr. and Mrs. Alex Howson Mr. and Mrs. Frank R. Liggett, III Mr. and Mrs. Jack E. Miller, Jr. Mr. and Mrs. George G. Hunt Mr. Gordon Light Mr. and Mrs. John F. Mitchell Mr. James V. Hunt Ms. Nancy E. Liipfert and Mr. B.B. Mr. R.E. Mitchell Ms. Judy Hunt Liipfert, Jr. Mobil-MG Mr. and Mrs. J. Edwin Hunter Mr. and Mrs. Thomas J. Lindsey Mr. Jeffrey L. Moe and Mrs. Audrey Drs. Robert R. and Joan C. Huntley Ms. Dorothy J. Lineberger M. Green Mr. Larry A. Hyde Ms. Jean Lineberry Mr. J. Edgar Moore Mr. Archie G. Israel Mr. and Mrs.Vladimir Litvinenko Mr. and Mrs. S.A. Moore The Ivy Cottage Mr. and Mrs. Frank H. Livingston Mr. and Mrs.Tingley Moore Mr. and Mrs. Paul Ivey Ms. Mary L. Lloyd Mr. Thomas A. Morrow Mr. and Mrs. Jacques Jacquet Mr. Glenn Logue Mrs. Charlotte S. Murchison and Jefferson-Pilot Corp. - MG Mr. and Mrs. Edward S. Long Mr. David R. Murchison, Jr. Mr. and Mrs. Roger D. Jennings Mrs. Meta G. Long Capt. and Mrs. Hugh Murphree Mr. Jun H. Jiang and Mrs. Haitao Mr. and Mrs. Willie Long Mr. Thomas W. Murray Hu Mr. Thomas C. Looney Mr. and Mrs.William T. Murray Johnny T-Shirt Mr. and Mrs. Joseph C. Lore Nashville Lions Club Mr. and Mrs. Loran Johnson, Jr. Mr. and Mrs. Kurt Low Mr. and Mrs. Joseph R. Neikirk Mr. George Johnson, Jr. Mr. and Mrs.Vincent Lu Ms. Ilene Nelson Ms. Alexandra E. Johnson Mrs. James A. Lucas Mrs. Elizabeth Wharton Newland Ms. Kristina M. Johnson Mr. Robert P. MacKenzie III Mr. and Mrs. Matthew W. Newsom Mr. J. Phillips Johnston Mr. and Mrs. James E. Malpass Mr. John T. Nixon, Jr. Ms. Phyllis A. Jones Ms. Rachel E. Mann North Carolina Psychoanalytic Ms. Stephanie L. Jones Mr. and Mrs. Nicholas A. Mans Foundation, Inc. Mr. and Mrs. John R. Jordan, Jr. Mr. and Mrs. Barry E. Marshall Northeast Region CSI, Inc. Ms. Patricia B. Jordan Mr. Thomas S. Marshall Mr. and Mrs. Patrick J. Norton, Jr. UNC Lineberger was a co-sponsor of this year’s American Cancer Society “Relay for Life” in Dr. and Mrs. William S. Joyner Ms. Lois R. Martin Mr. and Mrs. William E. Orange County. UNC participants included: front (left to right): Gartrell White; Kerry Mr. and Mrs. Robert S. Kadis Ms. Victoria L. Martin Nottingham Ashburner; postdoctoral fellow Brian Ashburner; postdoc Kate Guttridge; Stephanie Stahl; postdoc Mr. and Mrs. Michael H. Kaelin Mr. Clint Massengill and Mrs. Luise Mr. and Mrs. Chalmers M. Nunn, Jr. Sandy Westerheide; Vasiliki Anest; Allison Hawke; and Dr. Tom Shea, director of UNC Lineberger Mr. and Mrs. John D. Kasarda K. Weinrich Mr. and Mrs. Elmer R. Oettinger, Jr. Bone Marrow and Stem Cell Transplantation Program. Back (left to right): Relay for Life chair Mr. and Mrs. John D. Kelly Master Terrazzo Technologies, LLC Ms. Mary W. Oliver Mr. and Mrs. William J. Kennedy, III Ms. Cathleen J. Matanle Ms. Regina W. Oliver Marc Huber; postdoctoral fellows Denis Guttridge, who was the scientific speaker for the event; Dr. W.E. Kidd Ms. Akira Matsumoto Mr. and Mrs. Gerald T. Olson Alan Howe; and Noel Hawke. Mr. and Mrs. Vernon G. Kight Mr. Earl B. McClanahan Mr. and Mrs. Robert H. Otto Mr. and Mrs. Gary M. Killian Mr. Jessie K. McCumbee Ms. Virginia L. Overton Design Lines Limited Mr. and Mrs. Ronald J. Gammon, Jr. Mr. and Mrs. Thomas W. Hicks Mr. W.H. Kincheloe Mr. J.E. McGee Ms. Susan N. Palmer Mr. and Ms. Daniel W. Desmond Gap Foundation Mr. and Mrs. Fred Hicks Mr. James King, Jr. Mrs. Dorothy McGehee Ms. Elizabeth G. Palmer Mr. Dexter Mr. and Mrs. Thomas S. Gardner Ms. Edna Higby Mr. and Mrs. Louis D. Kirkbride Mrs. Pauline M. McGirt Mr. and Mrs. Francis I. Parker Mr. James R. Dickens Mr. and Mrs. G.T. Gardner Mr. Gary P. Hill, D.D.S., M.S. Mr. and Mrs. Robert E. Kirkland, Jr. Kay McGovern and Associates Mrs. Nathalie J. Partlo Mr. and Mrs.William F. Dillenburg Mrs. L.T. Garner Mr. and Mrs. Thomas B. Hines Dr. and Mrs. David G. Klapper Mr. and Mrs. Richard McKee Mr. Charles Parton Mr. and Mrs. Robert S. Doran, Jr. Mr. and Mrs. George C. Gasperson, Mr. Jack P. Hitchcock Klein and Company, Inc. Mr. and Mrs. Dwight L. McKeel Ms. Elizabeth K. Pate Mr. James Dorsett, Jr. Jr. Mr. and Mrs. Charles F. Hobgood Mr. and Mrs. Robert H. Kluttz Mr. and Mrs. Charles C. McKinney Mr. and Mrs. William T. Patten Dr. Edgar S. Douglas, Jr. Mr. John F. Gaylord, Jr. Drs. Hoffman & Jordan, D.D.S., P.A. Mr. Paul A. Kohut R.E. McLean Tank Co., Inc. Ms. Norene Payne Mr. and Mrs. Edward K. Downing Mr. and Mrs. Sterling Gilliam Mr.*and Mrs. William F. Hogan Mr. and Mrs. John P. Konold Jack McManus Heating and A.C. Mr. Marvin M. Pearlman and Robie Ms. Byah Doxey Glaxo Wellcome, Inc. - MG Ms. Lara G. Hoggard Mr. Sanford L. Korschun Mr. and Mrs. George McMillan Pearson Ms. E. Maxine Doyle Mr. Stuart H. Gold Holden Crossing Limited KPMG, LLP Mr. and Mrs. R.D. McMillan, Jr. Mr. and Mrs. Phillip Earl Pearson Mr. and Mrs. James N. Duggins, Jr. Drs. Robert N. Golden and Shannon Partnership Drs. Jan A. and Etta Pisano Kylstra Mr. and Mrs. John McNeill, Jr. Joe Pecheles Volkswagon, Inc.

8 cancerLines Fall 2001 Center ’00-’01 More Inside

Mr. Brant R. Snavely Dr. and Mrs. Bill C. Terry Mr. and Mrs. J. Edmund Welch Dr. William D. Snider Mr. and Mrs. Robert V. Thibault Ms. Elaine Werner Mr. and Mrs. Dennis Sorhagen Dr. and Mrs. Colin G. Thomas, Jr. Mr. and Mrs. Joseph R. J. Mitchell Sorrow, Jr., M.D. Mr. Lewis W. Thompson Westmoreland, II Ms. Twyla Southerland Mr. James R.Thompson Mr. and Mrs. Robert P. Whaling Mr. and Mrs. Charles N. Spencer Mr. and Mrs. R.E. Thompson, Jr. Mr. and Mrs.William E. Wheeler Mrs. T. Boyd Spiller Mr. and Mrs. Russell A. Thompson, Mr. and Mrs. A. Bartlett White Mr. and Mrs.William Squire Jr. Ms. Doloretta S. White Mr. Thomas R. Staab, II Thompson Cadillac Olds Mr. and Mrs. James White Ms. Mary L. Stall Mr. and Mrs. Daniel D.Tidwell Mrs. Sydnor M. White, Sr. Ms. Barbara Crawford Stanley Mrs. Ann H. Tillery Mr. Thomas B.White Mr. Wayne T. Stephens Mr. W. Lyndo Tippett Mr. and Mrs.Theodore C. Mr. and Mrs. Alan W. Stirling Mr. and Mrs. Frank Tooke Whitehouse Mr. William T. Stokes, IV Mr. and Mrs. Braxton B. Townsend, Mr. and Mrs. Clarence E. Wilkins Mr. and Mrs. Aubrey L. Stoltz Jr. Dr. and Mrs. Kenneth W. Wilkins Mr. and Mrs.Warren G. Stone Mrs. Marguerite T. Trexler C.W. Williams & Co., Inc. Mr. S.M. Stott and Mrs. Thelma J. Trotter Brothers Carpets Mr. and Mrs. Clarence E. Williams, Martin Mr. and Mrs. Steven A.Tulip Jr. Mr. J.B. Strandberg Mr. John B.Turner Mr. Jesse C. Williams, Jr. Mrs. George T. Stronach United Way of Tri-State Mrs. Mishew C. Williams Structural Systems, Inc. Drs. Charles M. Van Der Horst and Mr. Coy O. Williard, Jr. Mr. and Mrs. Robert K. Stuart Laura Svetkey Mr. and Mrs.William D. Wilson Ms. Janice J. Summey Ms. Carolyn Van Sant Mr. and Mrs. Robert W. Winston Summit Packaging Products Ms. Mary E. Venable Dr. and Mrs. Kenneth H. Winter Mr. and Mrs. James A. Swenberg VFW Ladies Auxiliary Post 6060 Mr. and Mrs. Daniel H. Wolfe, Jr. Mr. and Mrs. James M.Tanner, Jr. Mrs. Jean M. Vickery Mr. Harry G. Womble UNC Lineberger’s team was close to 400 for this year’s NC Triangle Race for the Cure. The race Mr. Michael W. Tarr Mr. Warren W. Walk Ms. A. Lorraine Woodyard Tart & Tart, Inc. Mr. J. Elwood Walker Mr. and Mrs. Ford S. Worthy, Jr. attracted over 15,000 participants and raised over $520,000 for breast cancer. Taking part were Dr. and Mrs. David T. Tayloe, Sr. Ms. Karen M. Wall Ms. Elizabeth L. Wright UNC Lineberger Board of Visitors and Breast Center Advisory Board member Missy Julian-Fox Mr.* and Mrs. Caswell Taylor, Jr. Mr. L. G. Walton Jean L. Wynne (far right) and her daughter Betsy and UNC Lineberger “Sole Sister” team member Betty Bouldin Ms. Joan G. Taylor Mr. L. Graham Walton, Sr. Mr. J. Hale Yokley (left) and daughter Katherine. Mr. and Mrs. Philip Taylor Mr. and Mrs. Jerry G. Wampfler Mr. and Mrs. Robert J. Young Mr. and Mrs.William W. Taylor, Jr. Mr. and Mrs. Marvin Ward Mr. and Mrs. Robert J. Zalzneck Ms. Marsella D. Teachey Mr. and Mrs. David A. Wasserman Mr. and Mrs. Andrew E. Zeman Jonathan L. Peeler Revocable Trust Mrs. Nelle H. Reaves Mr. and Mrs. Andrew J. Schindler Mr. and Mrs.William Teague Waters Construction Co. Mr. and Mrs. David A. Zendels Mr. J.R. Peletier Mr. and Mrs. G. Gray Reed Mr. and Mrs. Bryan M. Scott Mr. and Mrs. Steven F. Techet Mr. and Mrs. P.J. Watkins, III Performance BMW Mr. and Mrs. Alfred O. Reid, Jr. Mr. and Mrs. J. Frank Scott Terrazzo Promotion Committee of Mr. and Mrs. Gary Weaver Mr. and Mrs. Warner Perry Ms. Mary L. Resch Dr. Rona Scott 11 Southeast, Inc. Mr. David F. Weinstein Drs. Thomas D. Petes and Rosann Mr. Foster C. Richards Mr. and Mrs. Kevin S. Scully Farber Petes Ms. Katherine K. Richards SE&M Constructors Dr. Leon E. Petty Ms. Kathleen H. Rivers Mr. and Mrs. H. Ronald Searle Pharr Yarns, Inc. Riverside Veterinary Hospital Mr. W.L. Seawell, Jr. Tim Phelps and Company RJR Nabisco Ms. Mary P. Sechriest Mr. Gary Phillips Mrs. Melanie Robbins Ms. Rita Denise Secreast-Doll Mr. Michael D. Phillips Mr. William R. Roberson, Jr. Dr. and Mrs. John T. Sessions Mr. S.D. Phillips Dr. C.E. Roberts Mr. and Mrs. James B. Sessoms Mr. and Mrs. Hubert J. Philpott Mr. Virgil Bruce Roberts, Jr. Mr. and Mrs. Cecil Sewell Mr.* and Mrs. Warren T. Piver Ms. Jean R. Roberts Mr. and Mrs. Robert E. Seymour Pizza Inn of Rocky Mount I, Inc. Ms. Elizabeth L. Robey Mr. and Mrs. Suhail A. Shaikh Mr. and Mrs. Greg Pleasants Mr. and Mrs. Marcel G. Robins Ms. Mary B. Shannon Mrs. Ruth B. Plyler Mr. and Mrs. Joe Robinson Mr. and Mrs. David P. Shaw Mr. and Mrs. Michael K. Poe Rocky Mount Orthopaedic and Mr. Robert L. Shaw Mr. William D. Poe, Jr. Sports Medicine Center Ms. Nell H. Shaw Mr. and Mrs. Stuart W. Point Mr. Robert H. Rogge Mr. Martin F. Shelley Mr. and Mrs. C. Grey Poole Mrs. Lyle G. Ross Mr. and Mrs.Thomas Shelly Mr. E.J. Pope, Jr. Mr. and Mrs. James L. Rowe Mrs. Elizabeth H. Shinn Mr. and Mrs. Thomas A. Porter RSM McGladrey Ms. Karen Shore Ms. Molly Larsen Pratt Mrs. Elizabeth M. Ruffin Mr. and Mrs.William S. Shrago Premier Ford Linclon Mercury Mr. and Mrs. Harvey B. Ruffin Mrs. Nancy H. Sitterson Mr. Harry Prevette Mr. Larry J. Russell Mr. and Mrs. Kenneth R. Smith, Jr. Mr. James Prevette Mr. and Mrs. Russ Russell Dr. and Mrs. Alton L. Smith, Jr. PriceWaterhouseCoopers Mr. and Mrs. Edward D. Salmon Mr. Herbert W. Smith Procter & Gamble Company - MG Ms. Elaine Elden Sandman Mr. J. Keith Smith and Ms. Lisa L. Mr. and Mrs. William A. Pully Mr. and Mrs. Joseph T. Saputo Jones Mr. Hubert H. Rand Mr. Irwin Sawitz Mr. J. Troy Smith, Jr. Mrs. Ann Page Ransdell Dr. and Mrs. Charles J. Sawyer III Ms. Michelle L. Smith At the UNC Lineberger Club annual brunch and basketball game, Board of Visitors member Dr. Marjorie S. and Mr. J.M. Read Mr. and Mrs. Braxton Schell Mr. and Dr. R.W. Smith, Jr. John Burress was the emcee and he auctioned a basketball signed by the UNC men’s basketball Ms. Harriette A. Reaves Ms. Susan O. Scherer Mr. and Mrs. Steven J. Smith team. The ball was purchased for $2,000 by Board member Robert Williamson Jr.

istered by sub-cutaneous injection. This trial will Myelodysplastic Syndrome (D-0007). This is Clinical Trials Underway help to determine if the new agent added to stan- a Phase III trial of a novel agent, Decitabine, deter- dard chemotherapies for colon cancer will improve For information about any of these trials, please mining the efficacy and safety in patients with ad- the response rate. Safety and drug tolerability will call 919-966-4432 or visit the UNC LCCC website vanced stage disease. Patients are randomized to be monitored. PIs, Stephen Bernard, MD and Bert at http://cancer.med.unc.edu/patient/protocols. receive either Decitabine or supportive care meas- O’Neill, MD. ures. This trial will also assess the patient’s quality Non-Snall Cell Lung Cancer Stage IIIB/IV Renal Cell Malignancies (C-100-12). This is of life during participation. PI, Beverly Mitchell, MD. (LCCC 2003). This is a Phase II investigator a multi-center, randomized Phase III study of GI Malignancies (RPI0003). This is a Phase II initiated trial. Patients are randomized to receive Oncophage versus observation in patients with a multi-center trial of a new agent, Angiozyme, in weekly Taxol and every three week carboplatin or high risk for recurrence after surgery for renal cell combination with chemotherapeutic agents 5-FU, every three week Taxol and carboplatin. This trial is carcinoma. Oncophage is a vaccine developed Leucovorin and Irinotecan in patients with meta- designed to determine the toxicities related to the from the patient’s own tumor. This treatment rep- static colorectal cancer. Angiozyme is a complete- differing treatment schedules, how well patients re- resents a unique opportunity to deliver a vaccine ly new approach to destroying the blood vessel spond to treatment, patients’ quality of life during specific to that patient hoping to achieve long growth factor made by tumors. It was developed to treatment, and to estimate survival between the lasting immunity against this tumor. PI, Raj Pruthi, inhibit tumor growth and spread and is admin- two treatment groups. PI, Mark Socinski, MD. MD.

cancerLines Fall 2001 9 A Panoramic View UNC’s new infusion area

The new infusion area opened July 10 on the ground floor of the clinical cancer center. This new space triples the number of therapy chairs for patients and offers additional space for family and friends to be near their loved one during therapy. (See page 2 for dedication ceremony photo).

NewToll-Free Number We welcome the following new clinical faculty for Patients and Referring Physicians who have recently joined UNC Lineberger: Call 1-866-828-0270 to make an appointment Drs. Nancy DeMore, Cherie Dunphy, Lev Goyal, or get information about UNC Lineberger cancer Margaret Gulley, H.J. Kim, Chad Livasy, and Bert programs. O’Neil.

calendar UNC Lineberger Comprehensive Cancer Center Nonprofit Organization CB# 7295 U.S. Postage School of Medicine PAID of events University of North Carolina at Chapel Hill Permit No. 71 Chapel Hill, NC 27599-7295 Chapel Hill, NC 27599-1110 (919) 966-3036 J ANUARY 2002 http://cancer.med.unc.edu Return Forwarding, and Return Postage Guaranteed. 12th Lineberger Club Annual Address Correction Requested. Brunch/Basketball Game. Kenan Center, Chapel Hill, NC.

M ARCH 2002

27-28th 26th Annual Scientific Symposium “Developmental Biology: Implications for Human Cancers.” Friday Center, Chapel Hill, NC.

A PRIL 2002

19th UNC Medical Center 50th Anniversary Symposium: “Exploring Medicine in the Post-Genome Era.” Friday Center, Chapel Hill, NC.

10 cancerLines Fall 2001