JEFFREY B. BLUMBERG, Phd, FASN, FACN, CNS-S NARRATIVE RESUME
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Extracts from Sageretia Thea Reduce Cell Viability Through Inducing Cyclin
Kim et al. BMC Complementary and Alternative Medicine (2019) 19:43 https://doi.org/10.1186/s12906-019-2453-4 RESEARCH ARTICLE Open Access Extracts from Sageretia thea reduce cell viability through inducing cyclin D1 proteasomal degradation and HO-1 expression in human colorectal cancer cells Ha Na Kim1†, Gwang Hun Park2†, Su Bin Park1, Jeong Dong Kim1, Hyun Ji Eo2, Ho-Jun Son2, Jeong Ho Song2 and Jin Boo Jeong1,3* Abstract Background: Sageretia thea (S. thea) has been used as the medicinal plant for treating hepatitis and fevers in Korea and China. Recently, anticancer activity of S. thea has been reported, but the potential mechanism for the anti- cancer property of S. thea is still insufficient. Thus, we evaluated whether extracts from the leaves (STL) and branches (STB) of S. thea exert anticancer activity and elucidated its potential mechanism in SW480 cells. Methods: MTT assay was performed for measuring cell viability. Western blot and RT-PCR were used for analyzing the level of protein and mRNA, respectively. Results: Treatment of STL or STB decreased the cell viability and induced apoptosis in SW480 cells. Decreased level of cyclin D1 protein was observed in SW480 cells treated with STL or STB, but no change in cyclin D1 mRNA level was observed with the treatment of STL or STB. MG132 blocked downregulation of cyclin D1 protein by STL or STB. Thr286 phosphorylation of cyclin D1 by STL or STB occurred faster than downregulation of cyclin D1 protein in SW480 cells. When SW480 cells were transfected with T286A-cyclin D1, cyclin D1 degradation by STL or STB did not occur. -
A Phylogenetic Analysis of Rhamnaceae Using Rbcl and Trnl-F Plastid DNA Sequences James E. Richardson
A Phylogenetic Analysis of Rhamnaceae using rbcL and trnL-F Plastid DNA Sequences James E. Richardson; Michael F. Fay; Quentin C. B. Cronk; Diane Bowman; Mark W. Chase American Journal of Botany, Vol. 87, No. 9. (Sep., 2000), pp. 1309-1324. Stable URL: http://links.jstor.org/sici?sici=0002-9122%28200009%2987%3A9%3C1309%3AAPAORU%3E2.0.CO%3B2-5 American Journal of Botany is currently published by Botanical Society of America. Your use of the JSTOR archive indicates your acceptance of JSTOR's Terms and Conditions of Use, available at http://www.jstor.org/about/terms.html. JSTOR's Terms and Conditions of Use provides, in part, that unless you have obtained prior permission, you may not download an entire issue of a journal or multiple copies of articles, and you may use content in the JSTOR archive only for your personal, non-commercial use. Please contact the publisher regarding any further use of this work. Publisher contact information may be obtained at http://www.jstor.org/journals/botsam.html. Each copy of any part of a JSTOR transmission must contain the same copyright notice that appears on the screen or printed page of such transmission. The JSTOR Archive is a trusted digital repository providing for long-term preservation and access to leading academic journals and scholarly literature from around the world. The Archive is supported by libraries, scholarly societies, publishers, and foundations. It is an initiative of JSTOR, a not-for-profit organization with a mission to help the scholarly community take advantage of advances in technology. -
Rules and Regulations Federal Register Vol
2481 Rules and Regulations Federal Register Vol. 69, No. 11 Friday, January 16, 2004 This section of the FEDERAL REGISTER 56806, Docket No. 98–103–1) a proposal implementing the procedural provisions contains regulatory documents having general to amend the regulations governing the of NEPA (40 CFR parts 1500–1508), (3) applicability and legal effect, most of which importation of plants and plant USDA regulations implementing NEPA are keyed to and codified in the Code of products to allow artificially dwarfed (7 CFR part 1b), and (4) APHIS’s NEPA Federal Regulations, which is published under plants (penjing) of the genera Buxus, Implementing Procedures (7 CFR part 50 titles pursuant to 44 U.S.C. 1510. Ehretia (Carmona), Podcarpus, 372). On September 15, 2003, we The Code of Federal Regulations is sold by Sageretia, and Serissa to be imported published in the Federal Register (68 the Superintendent of Documents. Prices of into the United States from the People’s FR 53956–53957, Docket No. 98–103–3) new books are listed in the first FEDERAL Republic of China in an approved a notice announcing the availability of REGISTER issue of each week. growing medium subject to specified the environmental assessment, and growing, inspection, and certification solicited comments on the requirements. We proposed this action environmental assessment for 30 days DEPARTMENT OF AGRICULTURE after assessing the pest risks associated ending October 15, 2003. On October with the importation of penjing 28, 2003, we published in the Federal Animal and Plant Health Inspection established in growing media from the Register (68 FR 61391–61392, Docket Service People’s Republic of China under the No. -
Report of Rapid Biodiversity Assessments at Cenwanglaoshan Nature Reserve, Northwest Guangxi, China, 1999 and 2002
Report of Rapid Biodiversity Assessments at Cenwanglaoshan Nature Reserve, Northwest Guangxi, China, 1999 and 2002 Kadoorie Farm and Botanic Garden in collaboration with Guangxi Zhuang Autonomous Region Forestry Department Guangxi Forestry Survey and Planning Institute South China Institute of Botany South China Normal University Institute of Zoology, CAS March 2003 South China Forest Biodiversity Survey Report Series: No. 27 (Online Simplified Version) Report of Rapid Biodiversity Assessments at Cenwanglaoshan Nature Reserve, Northwest Guangxi, China, 1999 and 2002 Editors John R. Fellowes, Bosco P.L. Chan, Michael W.N. Lau, Ng Sai-Chit and Gloria L.P. Siu Contributors Kadoorie Farm and Botanic Garden: Gloria L.P. Siu (GS) Bosco P.L. Chan (BC) John R. Fellowes (JRF) Michael W.N. Lau (ML) Lee Kwok Shing (LKS) Ng Sai-Chit (NSC) Graham T. Reels (GTR) Roger C. Kendrick (RCK) Guangxi Zhuang Autonomous Region Forestry Department: Xu Zhihong (XZH) Pun Fulin (PFL) Xiao Ma (XM) Zhu Jindao (ZJD) Guangxi Forestry Survey and Planning Institute (Comprehensive Tan Wei Fu (TWF) Planning Branch): Huang Ziping (HZP) Guangxi Natural History Museum: Mo Yunming (MYM) Zhou Tianfu (ZTF) South China Institute of Botany: Chen Binghui (CBH) Huang Xiangxu (HXX) Wang Ruijiang (WRJ) South China Normal University: Li Zhenchang (LZC) Chen Xianglin (CXL) Institute of Zoology CAS (Beijing): Zhang Guoqing (ZGQ) Chen Deniu (CDN) Nanjing University: Chen Jianshou (CJS) Wang Songjie (WSJ) Xinyang Teachers’ College: Li Hongjing (LHJ) Voluntary specialist: Keith D.P. Wilson (KW) Background The present report details the findings of visits to Northwest Guangxi by members of Kadoorie Farm and Botanic Garden (KFBG) in Hong Kong and their colleagues, as part of KFBG's South China Biodiversity Conservation Programme. -
Lianas Neotropicales, Parte 5
Lianas Neotropicales parte 5 Dr. Pedro Acevedo R. Museum of Natural History Smithsonian Institution Washington, DC 2018 Eudicots: •Rosids: Myrtales • Combretaceae • Melastomataaceae Eurosids 1 Fabales oFabaceae* o Polygalaceae Rosales o Cannabaceae o Rhamnaceae* Cucurbitales oCucurbitaceae* o Begoniaceae Brassicales o Capparidaceae o Cleomaceae o Caricaceae o Tropaeolaceae* Malvales o Malvaceae Sapindales o Sapindaceae* o Anacardiaceae o Rutaceae Fabales Fabaceae 17.000 spp; 650 géneros árboles, arbustos, hierbas, y lianas 64 géneros y 850 spp de trepadoras en el Neotrópico Machaerium 87 spp Galactia 60 spp Dioclea 50 spp Mimosa 50 spp Schnella (Bauhinia) 49 spp Senegalia (Acacia) 48 spp Canavalia 39 spp Clitoria 39 spp Centrocema 39 spp Senna 35 spp Dalbergia 30 spp Rhynchosia 30 spp Senegalia riparia • hojas alternas, usualm. compuestas con estipulas •Flores bisexuales o unisexuales (Mimosoid), 5-meras • estambres 10 o numerosos • ovario súpero, unicarpelado • frutos variados, usualm. una legumbre Fabaceae Dalbergia monetaria Senegalia riparia Entada polystachya Canavalia sp. Senna sp. Senna sp Vigna sp Senegalia sp Guilandina sp Schnella sp Dalbergia sp Dalbergia sp Dalbergia sp Machaerium sp Senegalia sp Guilandina ciliata Dalbergia ecastaphyllum Abrus praecatorius Machaerium lunatum Entada polystachya Mucuna sp Canavalia sp; con tallos volubles Senna sp; escandente Schnella sp: zarcillos Entada polyphylla: zarcillos Machaerium sp: escandente Dalbergia sp: ramas prensiles Senegalia sp: zarcillos/ramas prensiles Machaerium kegelii Guilandina ciliata Canavalia sp: voluble Dalbergia sp: ganchos Cortes transversales de tallos Machaerium cuspidatum Senna quinquangulata Deguelia sp. parenquima aliforme Tallos asimétricos Machaerium sp; tallo achatado Centrosema plumieri; tallo alado Schnella; tallo sinuoso Schnella sp; asimétrico Dalbergia sp; neoformaciones Rhynchosia sp; tallo achatado Schnella sp; cuñas de floema Machaerium sp cambio sucesivo Estipulas espinosas Machaerium 130 spp total/87 spp trepadoras Hojas usualm. -
Flora of China 12: 133–139. 2007. 7. SAGERETIA Brongniart, Mém. Fam
Flora of China 12: 133–139. 2007. 7. SAGERETIA Brongniart, Mém. Fam. Rhamnées, 52. 1826. 雀梅藤属 que mei teng shu Ampeloplis Rafinesque. Shrubs scandent or erect, rarely small trees, unarmed or spinescent. Branchlets alternate or subopposite, often terminating in a woody spine. Leaves alternate or subopposite; stipules small, caducous; leaf blade papery to leathery, pinnately veined, margin ser- rate, rarely entire. Flowers mostly very small, 1–2 mm in diam., bisexual, 5-merous, usually sessile or subsessile, rarely pedicellate, in spikes or spicate panicles, rarely in racemes. Calyx tube shallowly cup-shaped to hemispherical; sepals triangular, ± fleshy, adax- ially medially keeled and hooded. Petals spatulate, apex 2-lobed to ± deeply emarginate. Stamens equaling petals or slightly longer; anthers dorsifixed. Disk cup-shaped, thick, fleshy, outer margin free from calyx tube, ± distinctly erect, entire or 5-lobed. Ovary superior, 2- or 3-loculed, with 1 ovule per locule; style short, stout, undivided, apically ± distinctly 2- or 3-lobed. Drupe obovoid- globose, with 2 or 3 one-seeded stones, base with remnants of persistent calyx tube. Seeds compressed, slightly asymmetrical, concave at both ends. About 35 species: mainly in SE Asia, a few species in Africa and North America; 19 species (15 endemic) in China. Sageretia gongshanensis G. S. Fan & L. L. Deng (Sida 17: 677. 1997) and S. latifolia Handel-Mazzetti (Symb. Sin. 7: 673. 1933), both described from Yunnan, and S. yunlongensis G. S. Fan & L. L. Deng (Sida 16: 477. 1995), described from Xizang and Yunnan, could not be treated here because no material was seen by the authors. -
Meiotic Studies in Himalayan Celastraceae and Rhamnaceae T. S. Sareen, P. K. Khosla and P. N. Mehra Department of Botany, Panjab
Cytologia 39: 335-339, 1974 Meiotic Studies in Himalayan Celastraceae and Rhamnaceae T.S. Sareen, P.K. Khosla and P.N. Mehra Departmentof Botany,Panjab University, Chandigarh, India ReceivedNovember 25, 1972 The family Celastraceae embraces 850 species belonging to 55 woody genera with wide distribution except in the arctic. About 70 species and 12 genera are met in India. Two of these, Lophopetalum fimbriatum from Eastern Himalayas and L. wightianumfrom South India, yield commercial timber. Several species of Euonymusare ornamental. Rhamnaceae is a family of 58 genera and 900 species distributed in the tropical and temperate regions. Ten genera with roughly 40 species occur in India. Zizy phus jujuba and Z. xylopyrus yield low grade timber. Jujube is one of the most common wild fruit trees in India. This study was part of the wider project "Cytomorphological Investigations of Himalayan Hardwoods" undertaken by us from 1962-1967. The chromosome counts of newly studied species have been published in IOPB chromosome numbers reports (Mehra and Khosla 1969, Mehra and Sareen 1969). Table 1. Source of the material Material and methods The material for meiotic studies was collected from wild populations in the Himalayas. The flower buds were fixed in Carnoy's fluid. After one or two days anther squashes were prepared in 1.0% aceto-carmine. The photomicro graphs as also the camera lucida drawings are at a uniform magnification of •~1360. The voucher specimens have been kept in the Herbarium of the Botany Department of Panjab University . 336 T. S. Sareen, P. K. Khosla and P. N. Mehra Cytologia 39 Results and discussion The results of cytological studies on 21 species are summarized in Table 2. -
Perennial Edible Fruits of the Tropics: an and Taxonomists Throughout the World Who Have Left Inventory
United States Department of Agriculture Perennial Edible Fruits Agricultural Research Service of the Tropics Agriculture Handbook No. 642 An Inventory t Abstract Acknowledgments Martin, Franklin W., Carl W. Cannpbell, Ruth M. Puberté. We owe first thanks to the botanists, horticulturists 1987 Perennial Edible Fruits of the Tropics: An and taxonomists throughout the world who have left Inventory. U.S. Department of Agriculture, written records of the fruits they encountered. Agriculture Handbook No. 642, 252 p., illus. Second, we thank Richard A. Hamilton, who read and The edible fruits of the Tropics are nnany in number, criticized the major part of the manuscript. His help varied in form, and irregular in distribution. They can be was invaluable. categorized as major or minor. Only about 300 Tropical fruits can be considered great. These are outstanding We also thank the many individuals who read, criti- in one or more of the following: Size, beauty, flavor, and cized, or contributed to various parts of the book. In nutritional value. In contrast are the more than 3,000 alphabetical order, they are Susan Abraham (Indian fruits that can be considered minor, limited severely by fruits), Herbert Barrett (citrus fruits), Jose Calzada one or more defects, such as very small size, poor taste Benza (fruits of Peru), Clarkson (South African fruits), or appeal, limited adaptability, or limited distribution. William 0. Cooper (citrus fruits), Derek Cormack The major fruits are not all well known. Some excellent (arrangements for review in Africa), Milton de Albu- fruits which rival the commercialized greatest are still querque (Brazilian fruits), Enriquito D. -
TASTE ISRAEL at Anuga 2013
TASTE ISRAEL at Anuga 2013 Natural Organic ingredients ingredients Gluten free Innovative products October 5-9 ▪ Cologne ▪ Germany ▪ Hall 2.1 ▪ Stands C28/D25 2BFresh ■ 2BFresh uses advanced hydroponic production methods to produce fresh culinary herbs and lettuce free of insects, sand, pesticides, etc., supporting the strictest kosher certification. The company recently developed “micro greens,” gourmet vegetable confetti, full of intense flavor and stunning visual texture and color, made from a variety of vegetable plants harvested at the seedling stage. Mr Avner Shohet ■ Marketing Manager +972 9 894 0507 [email protected] www.2bfresh.com A.L. Manufacturing and Marketing ■ A.L. Manufacturing and Marketing, founded in 1922, produces private label spices, herbs and seasoning blends for two of Israel's largest retailers, plus our own Maimon's brand. We offer over 200 types of spices and seasoning blends, in any packaging, at the very highest quality. Mr Kfir Maimons ■ CFO +972 52 395 3511 [email protected] www.maimonspices.co.il Beth El Food ■ Aunt Berta was born 94 years ago, yet her recipes for handmade confitures, marmalades and sauces live on today. Over time, Aunt Berta’s kitchen was transformed into a modern manufacturing facility. Today, Beth El Food produces a wide range of confitures and sauces and handmade pralines – all free of preservatives and food coloring. Mr Muli Flint ■ Director Business Development +972 4 639 7733 [email protected] www.be-food.com Cohen-Or ■ Cohen Or, established in 1996, manufactures frozen pastry products in a large variety of types and flavors, both sweet and savory. -
Study Guide – Judaism in a Secular Age - Pathbreakers
Study Guide and Discussion Questions Part 2 – Pathbreakers Created by Jeremy Kridel Study Guide – Judaism in a Secular Age - Pathbreakers STUDY GUIDE: SIMON DUBNOW The Man and His Times: Simon Dubnow was born in Mstsislaw, in the Russian Pale of Settlement, in 1860. In his youth, he received a traditional Jewish education, studying in heder and yeshiva settings. By the time of Dubnow’s thirteenth birthday, the Russian government had established Jewish schools that used Russian as the language of instruction. Attending such schools would, together with passing entrance examinations, allow Jewish men to enroll in Russian universities. Dubnow persuaded his parents to allow him to attend one of these schools. In 1881, anarchists assassinat- ed Russian Tsar Alexander II. Responding to this event, in 1882 Russian authorities enacted the May Laws, which restricted Jewish migration and shut down government-run Jewish schools. The closed schools included the one Dubnow had been attending, and he was prevented from obtaining the diploma needed to enter university. During and after his period in Russian government schools, Dubnow studied the literature of the Haskalah [Jewish Enlightenment] movement, as well as contemporary British, German, and Rus- sian philosophers. Dubnow became interested in linguistics, history, and philosophy. He became particularly interested the Wissenschaft Des Judentums [“Scientific Study of Judaism”] move- ment in Germany. During this time, Dubnow also ceased to hold the traditional Jewish religious beliefs of his youth, and eventually determined that he no longer believed in any deity at all. Dubnow’s departure from Jewish religious faith did not mean that he left his Jewish identity be- hind. -
Pdf DIY Shabbat
! 1 DIY SHABBAT Even when the soul is seared, even when no prayer can come out of our tightened throats, the clean, silent rest of the Sabbath leads us to a realm of endless peace, or the beginning of an awareness of what eternity means.2 1 Oil painting by Ligtenberg, Blue and White Gallery, Jerusalem 2 Rabbi Abraham Joshua Heschel, The Sabbath, pg. 101 !1 DIY - Do It Yourself - Shabbat is a project of our hearts. We long for you to know the joy of G-d’s celebrations and the intimacy of meeting G-d our Father in them. Each Feast reminds us of who G-d is and who we are in Him - His children ‘born again’ by His Spirit in Yeshua ha’Mashiach, Messiah Jesus. But, many have not grown up in a home that celebrates the Biblical Festivals and so we often are asked, “Where does one start?” This is our answer… DIY Shabbat is a ’How To’ guide to jumpstart you in actively participating in the rhythm and flow of our Father’s Calendar. At HIS-ISRAEL we are about learning, doing, and sharing. To explore more in-depth understanding of each Feast (and to find additional recipes and craft ideas) please visit the drop down menu on HIS-ISRAEL.com titled Appointments with G-d. As you learn the relevance and meaning of these Mo’adim or ‘appointed times’ and move into their celebration we hope you will look for opportunities to share the enjoyment with others. ! © HIS-ISRAEL !2 ! EVERY SEVENTH SUNSET, Shabbat comes. -
Antitrust Enforcement of the Prohibition of Excessive Prices: the Israeli Experience
Antitrust Enforcement of the Prohibition of Excessive Prices: The Israeli Experience Yossi Spiegel Abstract Until recently, there was no antitrust enforcement of a prohibition of excessive pricing in Israel. However, in recent years, a large and growing number of motions to certify class actions alleging excessive prices have been filed, although so far, only one class action has been certified by the court and it may take years before a final verdict is issued. Given this trend and given that courts are yet to clarify what excessive prices are and when high prices are deemed excessive and violate the Israeli Antitrust Law, monopolies in Israel face a high degree of legal uncertainty. In this chapter, I review these developments in detail and discuss the lessons that can be drawn from the Israeli experience. 1 Introduction Under the Israeli Antitrust Law, it is unlawful for a monopoly to set “unfair purchase or selling prices.” Until recently, this provision was generally interpreted as referring to low predatory pricing, intended to force rivals out of the market. Things changed however quite substantially in the past few years. First, the Director General of the Israeli Antitrust Authority (IAA) issued in 2014 Guidelines 1/14, which state that unfair prices include high excessive prices. The guidelines also state that the IAA will begin to enforce the prohibition of excessive pricing and it presents the considerations and rules that will guide the IAA in its For helpful comments and discussions, I thank Itai Ater, Michal Gal, David Gilo, Nadav Miyara, Yannis Katsoulacos, and Amir Vang. Disclaimer: I am involved as an economic expert in two pending class actions concerning excessive pricing.