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Foodstuff Comprising an Extract of a Plant of the Genus Salacia and Flavonoid

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Foodstuff Comprising an Extract of a Plant of the Genus Salacia and Flavonoid (19) TZZ _Z___T (11) EP 2 185 011 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A23L 1/30 (2006.01) A61P 3/04 (2006.01) 10.06.2015 Bulletin 2015/24 A61P 3/10 (2006.01) (21) Application number: 08829226.3 (86) International application number: PCT/JP2008/066266 (22) Date of filing: 03.09.2008 (87) International publication number: WO 2009/031690 (12.03.2009 Gazette 2009/11) (54) FOODSTUFF COMPRISING AN EXTRACT OF A PLANT OF THE GENUS SALACIA AND FLAVONOID NAHRUNGSMITTEL MIT EINEM EXTRAKT AUS EINER PFLANZE DER GATTUNG SALACIA UND FLAVONOID PRODUIT ALIMENTAIRE COMPRENANT UN EXTRAIT DE PLANTE DU GENRE SALACIA ET UN FLAVONOÏDE (84) Designated Contracting States: (56) References cited: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR JP-A- 2000 086 653 JP-A- 2003 245 057 HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT JP-A- 2003 245 095 JP-A- 2003 267 881 RO SE SI SK TR • YOSHIKAWA M ET AL: "Salacia-Zoku (30) Priority: 06.09.2007 JP 2007231909 Shokubutsu no Polyphenol Seibun: alpha- 28.09.2007 JP 2007256732 Glucosidase Oyobi Aldose Reductase Sogai Kassei Seibun, Mangiferin, no Teiryo Bunseki/ (43) Date of publication of application: POLYPHENOL CONSTITUENTS FROM SALACIA 19.05.2010 Bulletin 2010/20 SPECIES: QUANTITATIVE ANALYSIS OF MANGIFERIN WITH ALPHA-GLUCOSIDASE AND (73) Proprietor: FUJIFILM Corporation ALDOSE REDUCTASE INHIBITORY ACTIVITIES" Tokyo 106-0031 (JP) YAKUGAKU ZASSHI - JOURNAL OF THE PHARMACEUTICALSOCIETY OF JAPAN, JP, vol. (72) Inventor: IKEDA, Kenji c/o FUJIFILM Corporation 121, no. 5, 1 January 2001 (2001-01-01), pages Ashigarakami-gun, Kanagawa (JP) 371-378, XP002984797 ISSN: 0031-6903 • HISASHI MATSUDA, TOSHIO MORIKAWA, (74) Representative: Hoffmann Eitle MASAYUKI YOSHIKAWA: "Antiodiabetogenic Patent- und Rechtsanwälte PartmbB constituents from several natural medicines" Arabellastraße 30 IUPAC, PURE APPL. CHEM., vol. 74, no. 7, 2002, 81925 München (DE) pages 1301-1308, XP002502831 Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations. Notice of opposition shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention). EP 2 185 011 B1 Printed by Jouve, 75001 PARIS (FR) EP 2 185 011 B1 Description TECHNICAL FIELD 5 [0001] This invention relates to a tablet or capsule which comprises an extract of a plant of the genus Salacia and a flavonoid. BACKGROUND ART 10 [0002] Recently, the number of persons having obesity or increased blood sugar level caused by the ingestion of high calorie food and overeating or lack of exercise, so-called reserve group of diabetes mellitus, has been increasing. To prevent this, supplements aimed at suppressing sugar absorption and fat absorption have been placed on the market. In addition, for the purpose of suppressing high blood sugar level and preventing diabetes mellitus,α-glucosidase inhibitors which suppress formation of glucose from starch and oligosaccharides are also on the market. 15 [0003] To prevent obesity, prevention of overeating by controlling consumption of calories and exercise are necessary, but their everyday practice is difficult in reality. In addition, theα-glucosidase inhibitors are effective not only as a therapeutic agent for diabetes mellitus but in dissolving obesity caused by overeating and lack of exercise and diet control. However, these agents (e.g., acarbose (mfd. by Bayer, trade name Gulcobay)), voglibose (mfd. by Takeda Chemical Industries, trade name Basen) and the like) are difficult to obtain, and when these are taken, absorption of 20 polysaccharides into the body can be suppressed but absorption of glucose and the like monosaccharides cannot be suppressed, so that significant sugar absorption-suppressing effect cannot be expected. In addition, problems of various side effects occur sometimes after their taking. Because of this, concern has been directed for the development of a safe and inexpensive natural-origin composition. [0004] As a natural material effective in satisfying such a requirement for obesity and sugar absorption suppression, 25 there are plants of the genus Salacia. The root and trunk of a plant of the genus Salacia have been used as a natural drug by a traditional medical science, aayurveda, in India and Sri Lanka. It has been handed down in Sri Lanka that the root skin of Salacia reticulata is effective in treating rheumatism, gonorrhea and a skin disease and is also used in the treatment of initial stage diabetes mellitus. In India, a root of Salacia oblonga is used in similar treatments, and it is said that Salacia chinensis is also used in the treatment of diabetes mellitus (FOOD Style 21, vol. 6, no. 5, pp. 72 - 78). 30 [0005] Thus, it has been handed down that plants of the genus Salacia are effective in the prevention and early stage treatment of diabetes mellitus. In recent years, it has been reported that a plant of the genus Salacia has the action to suppress increase of blood sugar level, and its action mechanism is the sugar absorption suppressing action based on the α-glucosidase activity inhibition (FOOD Style 21, vol. 6, no. 5, pp. 72 - 78). [0006] In addition, there are patents on the compounds which are contained in the extraction components of the genus 35 Salacia and have the action to inhibitα -glucosidase activity (Japanese Patent No. 3030008, JP-A-2004-323420 and JP-A-2000-86653), and their application examples and patents as anti-diabetic agents based on theα-glucosidase activity inhibitory action (JP-A-9-301882 and Japanese Patent No. 3261090). [0007] Since the sucrase inhibitory activity of most of the supplements on the market which use Salacia extract powder is standardized as 250 mg/ml or less, and when their sucrase inhibitory activity is actually measured, it is mostly about 40 350 mg/ml, so that it is necessary to increase the number of tablets in order to ingest effective amount. [0008] Concern has been directed toward the development of a high concentration Salacia extract powder, for the purpose of decreasing the number of tablets by increasing blending amount of Salacia extract powder per tablet. [0009] In addition, it is known that a large quantity of catechins as a kind of polyphenols are contained in the flavonoid- containing tea extract to be used in the invention. Anti-oxidation action, bactericidal action, anticancer action, blood 45 pressure lowering action, blood sugar level suppressing action and the like many physiological actions have been reported on such catechins, and in recent years, effectiveness of the fat combustion for its somatic fat reducing effect has further been reported (Shimotoyodome A., et al., Med. Sci. Sport Exerc., 37, 1884 - 1892, 2005 and Murase T., et al., Int. J. Obes. Relat. Metab. Disord., 30, 561 - 568, 2006). [0010] It has been reported that the effect to decrease body weight and somatic fat (abdominal total fat area, visceral 50 fat area) can be seen by the ingestion of high concentration catechin for a prolonged period of time. It is considered that a fat combusting enzyme in cells of the liver is activated by the high concentration catechin and thereby increase energy consumption by activating the fat metabolism, thus resulting in the reduction of somatic fat (Tsuchida T., Itakura H., Nakamura H., Prog. Med., 22, 2189 - 2203, 2002, Hackett A.M., et al., Eur. J. Drug Metab. Pharmacokinet, 8, 35 - 42, 1983, Murase T., et al., Int. J. Obes. Relat. Metab. Disord., 26, 1459 - 1464, 2002 and Ota N., et al., J. Health. Sci., 51, 55 233 - 236, 2005). [0011] It is possible to ingest catechin by drinking a green tea or the like tea, but since the content per cup is small, it is necessary to ingest a tea extract powder in the form of tablets or capsules for ingesting a desired amount. [0012] In addition, a tea extract contains catechin, epicatechin, gallocatechin, epigallocatechin, catechin gallate, epi- 2 EP 2 185 011 B1 catechin gallate, gallocatechin gallate and epigallocatechin gallate as catechins, or epigallocatechin gallate, epigallo- catechin, epicatechin gallate and gallocatechin in order of the content. [0013] In addition, the flavonoid to be used in the invention is roughly divided into flavonols, isoflavones and catechins. Among these, flavonols are a general term of polyphenols, and particularly among them, anti-oxidation action, bactericidal 5 action, anticancer action, immune action, fat combustion and the like many physiological actions have been reported on resveratrol, and further, its effectiveness for fat combustion has been confirmed. Also, effectiveness of the life- prolonging effect of mice which ingested a high calorie feed supplemented with resveratrol has been reported (Science. 275, 218, (1997) and Nature. Nov. 16th. (2006)). [0014] It is possible to ingest resveratrol by drinking or eating a grape extract or drinking red wine or the like, but since 10 the content per once is small, it is necessary to drink a large volume of red wine or ingest it in the form of tablets or capsules for ingesting a desired amount. [0015] In addition, vitamin C absorption support, anti-oxidation action, immune action and the like physiological actions have been reported particularly on quercetin among polyphenols, and it was further confirmed that this is effective in suppressing fat absorption (JP-T-2001-524119 (the term "JP-T" as used herein means a published Japanese translation 15 of a PCT patent application) and WO 01/076580). [0016] It is possible to ingest quercetin by eating an onion, but since the content per once is very small because the skins are not generally used for food.
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