Helicobacter Pylori's Historical Journey Through Siberia and the Americas
Helicobacter pylori’s historical journey through Siberia and the Americas Yoshan Moodleya,1,2, Andrea Brunellib,1, Silvia Ghirottoc,1, Andrey Klyubind, Ayas S. Maadye, William Tynef, Zilia Y. Muñoz-Ramirezg, Zhemin Zhouf, Andrea Manicah, Bodo Linzi, and Mark Achtmanf aDepartment of Zoology, University of Venda, Thohoyandou 0950, Republic of South Africa; bDepartment of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy; cDepartment of Mathematics and Computer Science, University of Ferrara, 44121 Ferrara, Italy; dDepartment of Molecular Biology and Genetics, Research Institute for Physical-Chemical Medicine, 119435 Moscow, Russia; eDepartment of Diagnostic and Operative Endoscopy, Pirogov National Medical and Surgical Center, 105203 Moscow, Russia; fWarwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom; gLaboratorio de Bioinformática y Biotecnología Genómica, Escuela Nacional de Ciencias Biológicas, Unidad Profesional Lázaro Cárdenas, Instituto Politécnico Nacional, 11340 Mexico City, Mexico; hDepartment of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom; and iDepartment of Biology, Division of Microbiology, Friedrich Alexander University Erlangen-Nuremberg, 91058 Erlangen, Germany Edited by Daniel Falush, University of Bath, Bath, United Kingdom, and accepted by Editorial Board Member W. F. Doolittle April 30, 2021 (received for review July 22, 2020) The gastric bacterium Helicobacter pylori shares a coevolutionary speakers). However, H. pylori’s presence, diversity, and structure history with humans that predates the out-of-Africa diaspora, and in northern Eurasia are still unknown. This vast region, hereafter the geographical specificities of H. pylori populations reflect mul- Siberia, extends from the Ural Mountains in the west to the tiple well-known human migrations. We extensively sampled H.
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