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Y-BOCS™ (Yale-Brown Obsessive-Compulsive Scale) Principal Developer: Wayne K. Goodman, M.D. Co-Developers: Steven A. Rasmussen
FIRST EDITION 9/89 (Revised 05/20) Y-BOCS™ (Yale-Brown Obsessive-Compulsive Scale) Principal Developer: Wayne K. Goodman, M.D. Co-developers: Steven A. Rasmussen, M.D. Lawrence H. Price, M.D. Eric A. Storch, PhD. Investigators interested in using this rating scale should contact Dr. Goodman at <[email protected]>. © 1989, 2017 Wayne Goodman Additional information regarding the development, use, and psychometric properties of the Y-BOCS™ can be found in Goodman WK, Price LH, Rasmussen SA, et al.: The Yale-Brown Obsessive Compulsive Scale: Part I. Development, use, and reliability. Arch Gen Psychiatry (46:1006-1011, 1989). and Goodman WK, Price LH, Rasmussen SA, et al.: The Yale-Brown Obsessive Compulsive Scale): Part II. Validity. Arch Gen Psychiatry (46:1012-1016, 1989). Copies of a version of the Y-BOCS™ modified for use in children, the Children's Y-BOCS™ (CY-BOCS™) (Goodman WK, Rasmussen SA, & Price LH,), or the second editions of the Y-BOCS-II™ and CY-BOCS-II™ are available from Dr. Goodman on request. Y-BOCS™ General Instructions This rating scale is designed to rate the severity and record the types of symptoms in a patient diagnosed with obsessive- compulsive disorder (OCD). In general, the items depend on the patient's report; however, the final rating is based on the clinical judgment of the interviewer. Rate the characteristics of each item during the prior week up until and including the time of the interview. Scores should reflect the average (mean) occurrence of each item for the entire week. This rating scale is intended for use as a semi-structured interview. -
Self-Ambivalence in Obsessive-Compulsive Disorder
Self-Ambivalence in Obsessive-Compulsive Disorder Sunil S Bhar Submitted in total fulfilment of the requirements of the degree of Doctor of Philosophy July, 2004 Produced on acid-free paper Department of Psychology University of Melbourne ii iii Abstract According to the cognitive model, Obsessive-compulsive disorder (OCD) is maintained by various belief factors such as an inflated sense of responsibility, perfectionism and an overestimation about the importance of thoughts. Despite much support for this hypothesis, there is a lack of understanding about the role of self-concept in the maintenance or treatment of OCD. Guidano and Liotti (1983) suggest that individuals who are ambivalent about their self-worth, personal morality and lovability use perfectionistic and obsessive compulsive behaviours to continuously restore self- esteem. This thesis develops a model of OCD that integrates self-ambivalence in the cognitive model of OCD. Specifically, it explored the hypothesis that the OCD symptoms and the belief factors related to the vulnerability of OCD are mechanisms that provide relief from self- ambivalence. It addressed three questions. First, is self-ambivalence related to OCD symptoms and OCD-related beliefs? Second, to what extent is self-ambivalence specific to OCD, compared to other anxiety disorders? Third, to what extent is self-ambivalence important in accounting for response and relapse of OCD to psychological interventions? In order to explore these questions, a questionnaire measuring self- ambivalence was first developed and evaluated. Non clinical and clinical participants were recruited for research. Non-clinical participants (N = 269) comprised undergraduate students (N = 226: mean age = 19.55; SD = 3.27) and community controls (N = 43; mean age = 43.78; SD = 3.92). -
Quick-View Guides
Appendix A Quick-View Guides Compiled by Jennifer S. Mills 310 APPENDIX A QUICK-VIEW GUIDES 311 312 APPENDIX A QUICK-VIEW GUIDES 313 314 APPENDIX A QUICK-VIEW GUIDES 315 316 APPENDIX A QUICK-VIEW GUIDES 317 Appendix B Reprinted Measures Measures for Anxiety and Related Constructs 322 APPENDIX B Anxiety Control Questionnaire (ACQ) Listed below are a number of statements describing a set of beliefs. Please read each statement carefully and, on the 0–5 scale below, indicate how much you think each statement is typical of you. 1. I am usually able to avoid threat quite easily. 2. How well I cope with difficult situations depends on whether I have outside help. 3. When I am put under stress, I am likely to lose control. 4. I can usually stop my anxiety from showing. 5. When I am frightened by something, there is generally nothing I can do. 6. My emotions seem to have a life of their own. 7. There is little I can do to influence people’s judgments of me. 8. Whether I can successfully escape a frightening situation is always a matter of chance with me. 9. I often shake uncontrollably. 10. I can usually put worrisome thoughts out of my mind easily. 11. When I am in a stressful situation, I am able to stop myself from breathing too hard. 12. I can usually influence the degree to which a situation is potentially threatening to me. 13. I am able to control my level of anxiety. 14. There is little I can do to change frightening events. -
Architecture Moléculaire Des Récepteurs NMDA : Arrangement Tétramérique Et Interfaces Entre Sous-Unités Morgane Riou
Architecture moléculaire des récepteurs NMDA : Arrangement tétramérique et interfaces entre sous-unités Morgane Riou To cite this version: Morgane Riou. Architecture moléculaire des récepteurs NMDA : Arrangement tétramérique et inter- faces entre sous-unités. Neurosciences [q-bio.NC]. Université Pierre et Marie Curie - Paris VI, 2014. Français. NNT : 2014PA066081. tel-01020863 HAL Id: tel-01020863 https://tel.archives-ouvertes.fr/tel-01020863 Submitted on 8 Jul 2014 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. THESE DE DOCTORAT De l’Université Pierre et Marie Curie - Paris VI Ecole Doctorale Cerveau Cognition Comportement ARCHITECTURE MOLECULAIRE DES RECEPTEURS NMDA : ARRANGEMENT TETRAMERIQUE ET INTERFACES ENTRE SOUS-UNITES Présentée par : Morgane RIOU Institut de Biologie de l' Ecole Normale Supérieure (IBENS) CNRS UMR8197, INSERM U1024 Ecole Normale Supérieure, 46 rue d’Ulm, 75005 Paris Direction Générale de l' Armement Soutenue le 28 février 2014 devant le jury composé de : Pr. Germain TRUGNAN Président Dr. David PERRAIS Rapporteur Dr. Pierre -
Oncolytic Properties of Ampakines in Vitro DANIEL P
ANTICANCER RESEARCH 38 : 265-269 (2018) doi:10.21873/anticanres.12217 Oncolytic Properties of Ampakines In Vitro DANIEL P. RADIN, RICHARD PURCELL and ARNOLD S. LIPPA RespireRx Pharmaceuticals, Inc., Glen Rock, NJ, U.S.A. Abstract. Background/Aim: The 5-year survival rate of crucial for the consolidation of learning and memory (1, 2). glioblastoma (GBM) is ~10%, demonstrating that a new Over the past two decades, considerable strides have been therapeutic modality for this cancer is desperately needed. made in understanding AMPAR pharmacology, kinetics and Complicating the search for such a modality is that most large physiology by employing positive allosteric modulators molecules cannot pass through the blood brain barrier, so (PAMs) to delineate their function (3). For convenience, the molecules demonstrating efficacy in vitro may not be useful in term ampakines has been used to describe various classes of vivo because they never reach the brain. Recently, the selective drugs that act as PAM. serotonin reuptake inhibitor (SSRI) fluoxetine (FLX) was Ampakines are further categorized as Class I ampakines, identified as an effective agent in targeting GBM in vitro and also known as high-impact ampakines, and Class II in vivo by agonizing AMPA-glutamate receptors (AMPARs), ampakines, also known as low-impact ampakines (3). Class eliciting massive calcium influx and mitochondrial calcium I or high-impact ampakines increase AMPAR agonist overload and apoptosis. Materials and Methods: In the current binding affinity by stabilizing the channel open confirmation study, we used a colorimetric cell viability assay to determine of the AMPAR, thereby offsetting desensitization, and if we could enhance the oncolytic effect of FLX in vitro by pre- enhancing AMPAergic steady-state currents up to 100-fold treating cells with an AMPAR-positive allosteric modulator (4). -
Double Blind Randomized Controlled Trial of Deep Brain Stimulation for Obsessive- Compulsive Disorder: Clinical Trial Design
UC San Diego UC San Diego Previously Published Works Title Double blind randomized controlled trial of deep brain stimulation for obsessive- compulsive disorder: Clinical trial design. Permalink https://escholarship.org/uc/item/93m0r1w4 Authors McLaughlin, Nicole CR Dougherty, Darin D Eskandar, Emad et al. Publication Date 2021-06-05 DOI 10.1016/j.conctc.2021.100785 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Contemporary Clinical Trials Communications 22 (2021) 100785 Contents lists available at ScienceDirect Contemporary Clinical Trials Communications journal homepage: www.elsevier.com/locate/conctc Double blind randomized controlled trial of deep brain stimulation for obsessive-compulsive disorder: Clinical trial design Nicole C.R. McLaughlin a,b,*, Darin D. Dougherty c,d, Emad Eskandar c,d,1,2, Herbert Ward e, Kelly D. Foote f, Donald A. Malone g, Andre Machado g, William Wong h, Mark Sedrak i, Wayne Goodman j,3, Brian H. Kopell j, Fuad Issa k, Donald C. Shields l, Osama A. Abulseoud m, Kendall Lee n, Mark A. Frye n, Alik S. Widge c,d,o,4, Thilo Deckersbach p, Michael S. Okun f, Dawn Bowers q, Russell M. Bauer q, Dana Mason e, Cynthia S. Kubu g, Ivan Bernstein h, Kyle Lapidus r, David L. Rosenthal j,5, Robert L. Jenkins k, Cynthia Read a, Paul F. Malloy a,b, Stephen Salloway a,b, David R. Strong s, Richard N. Jones b, Steven A. Rasmussen a,b, Benjamin D. Greenberg a,b,t a Butler Hospital, 345 Blackstone Blvd, Providence, RI, 02906, USA b Alpert Medical School of Brown University, -
Y-BOCS Has Become the Gold Standard for Rating Symptom Severity in Patients with Obsessive-Compulsive Disorder (OCD)
© Goodman, Rasmussen, Price, & Storch, 2011 CCYY--BBOOCCSS--IIII CClliinniiccaall VVeerrssiioonn By the Principal Developers of the Yale-Brown Obsessive Compulsive Scale, Yale-Brown Obsessive Compulsive Scale-Second Edition, and Children's Yale-Brown Obsessive Compulsive Scale WAYNE K. GOODMAN, M.D.* STEVEN A. RASMUSSEN, M.D.† LAWRENCE H. PRICE, M.D.† ERIC A. STORCH, Ph.D.‡ *Department of Psychiatry Mount Sinai School of Medicine †Department Of Psychiatry and Human Behavior Brown University School of Medicine ‡ Department of Pediatrics University of South Florida © Goodman, Rasmussen, Price, & Storch, 2011 Individuals or organizations interested in using this rating scale should contact Dr. Goodman by email: <[email protected]>. INTRODUCTION TO THE 2011 REVISION Since its introduction in 1986, the Y-BOCS has become the gold standard for rating symptom severity in patients with obsessive-compulsive disorder (OCD). Shortly after its inception, the Children's Yale-Brown Obsessive-Compulsive Scale was created using the Y-BOCS structure. Like its adult counterpart, the CY- BOCS has been used as a primary outcome in virtually every major clinical trial involving youth with OCD. It has been translated into multiple languages and remains the standard for assessing symptom severity and treatment response. Despite this broad range of acceptance, over two decades of experience taught us that there is still room for improvement. Accordingly, we revised and created the CY-BOCS-II to address a number of issues that are reviewed below. The Y-BOCS-II -
Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors
The Journal of Neuroscience, September 28, 2005 • 25(39):9027–9036 • 9027 Cellular/Molecular Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors Rongsheng Jin,1 Suzanne Clark,4 Autumn M. Weeks,4 Joshua T. Dudman,2 Eric Gouaux,1,3 and Kathryn M. Partin4 1Department of Biochemistry and Molecular Biophysics, 2Center for Neurobiology and Behavior, and 3Howard Hughes Medical Institute, Columbia University, New York, New York 10032, and 4Department of Biomedical Sciences, Division of Neuroscience, Colorado State University, Fort Collins, Colorado 80523 Ligand-gated ion channels involved in the modulation of synaptic strength are the AMPA, kainate, and NMDA glutamate receptors. Small molecules that potentiate AMPA receptor currents relieve cognitive deficits caused by neurodegenerative diseases such as Alzheimer’s disease and show promise in the treatment of depression. Previously, there has been limited understanding of the molecular mechanism of action for AMPA receptor potentiators. Here we present cocrystal structures of the glutamate receptor GluR2 S1S2 ligand-binding domain in complex with aniracetam [1-(4-methoxybenzoyl)-2-pyrrolidinone] or CX614 (pyrrolidino-1,3-oxazino benzo-1,4-dioxan-10- one), two AMPA receptor potentiators that preferentially slow AMPA receptor deactivation. Both potentiators bind within the dimer interface of the nondesensitized receptor at a common site located on the twofold axis of molecular symmetry. Importantly, the poten- tiator binding site is adjacent to the “hinge” in the ligand-binding core “clamshell” that undergoes conformational rearrangement after glutamatebinding.Usingrapidsolutionexchange,patch-clampelectrophysiologyexperiments,weshowthatpointmutationsofresidues that interact with potentiators in the cocrystal disrupt potentiator function. We suggest that the potentiators slow deactivation by stabilizing the clamshell in its closed-cleft, glutamate-bound conformation. -
(12) United States Patent (10) Patent No.: US 8,039,468 B2 Greer (45) Date of Patent: Oct
US008O39468B2 (12) United States Patent (10) Patent No.: US 8,039,468 B2 Greer (45) Date of Patent: Oct. 18, 2011 (54) METHOD OF INHIBITION OF Denavit-Saubie et al., “Effects of opiates and methionine-enkephalin RESPRATORY DEPRESSIONUSING on pontine and bulbar respiratory neurones of the cat.” 1978, Brain POSITIVE ALLOSTERICAMPARECEPTOR Res., 155(1):55-67. MODULATORS Feldman et al. “Looking for inspiration: new perspectives on respi ratory rhythm.”2006, Nat. Rev. Neurosci., 7(3):232-24. (75) Inventor: John Greer, Edmonton (CA) Funk, G.D., et al. "Generation and transmission of respiratory oscil lations in medullary slices: role of excitatory amino acids.” (1993).J. (73) Assignee: The Governors of the University of Neurophysiol. 70(4): 1497-1515. Funk, G.D., et al. “Modulation of neural network activity in vitro by Alberta, Edmonton, AB (CA) cyclothiazide, a drug that blocks desensitization of AMPA receptors' 1995, J. Neurosci., 15:4046-4056. (*) Notice: Subject to any disclaimer, the term of this Goff, D.C., et al. "A placebo-controlled pilot study of the ampakine patent is extended or adjusted under 35 CX516 added to clozapine in schizophrenia.” J. Clin. U.S.C. 154(b) by 996 days. Psychopharmacol., 21(5):484-487. Greer J.J., et al. “Role of excitatory amino acids in the generation and (21) Appl. No.: 11/847,835 transmission of respiratory drive in neonatal rat.” 1991, J. Physiol. 437: 727-749. (22) Filed: Aug. 30, 2007 Greer, J.J., et al. Respiratory and locomotor patterns generated in the fetal rat brain stem-spinal cordinvitro, J. Neurophysiol., 67:996-999. -
Wo 2007/030697 A2
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date (10) International Publication Number 15 March 2007 (15.03.2007) PCT WO 2007/030697 A2 (51) International Patent Classification: (US). PIRES, Jammieson, C. [US/US]; 5942 Alleghany A61K 31/16 (2006.01) A61K 38/15 (2006.01) Street, San Diego, CA 92139 (US). MORSE, Andrew A61K 31/4406 (2006.01) A61K 31/19 (2006.01) [US/US]; 10542 Rancho Carmel Drive, San Diego, CA (21) International Application Number: 92128 (US). GITNICK, Dana [CA/US]; 1524 Via Risa, PCT/US2006/034996 San Marcos, CA 92078 (US). TREUNER, Kai [DE/US]; 7665 Palmilla Drive, #5204, San Diego, CA 92122 (US). (22) International Filing Date: DEARIE, Alejandro, R. [US/US]; 555 Naples St., Apt. 7 September 2006 (07.09.2006) #307, Chula Vista, CA 9191 1 (US). (25) Filing Language: English (74) Agents: LAU, Kawai et al.; Townsend and Townsend and (26) Publication Language: English Crew LLP, 12730 High Bluff Drive, Suite 400, San Diego, (30) Priority Data: CA 92130 (US). 60/715,219 7 September 2005 (07.09.2005) US (81) Designated States (unless otherwise indicated, for every 60/764,963 3 February 2006 (03.02.2006) US kind of national protection available): AE, AG, AL, AM, 60/785,713 24 March 2006 (24.03.2006) US AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, (71) Applicant (for all designated States except US): BRAIN- CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, CELLS, INC. -
CURRICULUM VITAE NAME: Wayne K. Goodman, MD. ADDRESS: Department of Psychiatry University of Florida College of Medicine Mcknigh
CURRICULUM VITAE NAME: Wayne K. Goodman, MD. ADDRESS: Department of Psychiatry University of Florida College of Medicine McKnight Brain Institute, Suite L4-100 100 Newell Drive Gainesville, FL 32611 ------------------------------------------------------------ --------------------------- PERSONAL --------------------- DATA: ----------------------------------------------------------- CAREER: 1998- Chairman, Department of Psychiatry, University of Florida College of Medicine 1998- Psychiatrist-in-Chief, Shands Healthcare, Gainesville, FL 1997-1998 Interim Chairman, Department of Psychiatry, University of Florida College of Medicine 1997-1999 Associate Chairman, Department of Psychiatry, University of Florida, Jacksonville, FL 1993-1997 Director, Psychiatric Specialty Clinics, Shands Hospital at the University of Florida College of Medicine 1993- Chief, Obsessive-Compulsive and Tourette's Disorders Clinic, Department of Psychiatry, University of Florida College of Medicine 1993-2001 Director, Clinical Trials Program, Department of Psychiatry, University of Florida College of Medicine 1993- Professor (Tenured), Department of Psychiatry, University of Florida College of Medicine 1992-1993 Associate Professor, Department of Psychiatry, Yale University School of Medicine 1990-1993 Associate Unit Chief, Clinical Neuroscience Research Unit, Yale University School of Medicine 1986-1992 Assistant Professor, Department of Psychiatry, Yale University School of Medicine 1985-1992 Chief and founder, Obsessive Compulsive Disorder Clinic, Yale University -
Ketamine Enhances Structural Plasticity in Mouse Mesencephalic and Human Ipsc-Derived Dopaminergic Neurons Via AMPAR- Driven BDNF and Mtor Signaling
Edinburgh Research Explorer Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR- driven BDNF and mTOR signaling Citation for published version: Cavalleri, L, Merlo Pich, E, Millan, MJ, Chiamulera, C, Kunath, T, Spano, PF & Collo, G 2017, 'Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling', Molecular Psychiatry, vol. 23, no. 4, pp. 812-823. https://doi.org/10.1038/mp.2017.241 Digital Object Identifier (DOI): 10.1038/mp.2017.241 Link: Link to publication record in Edinburgh Research Explorer Document Version: Peer reviewed version Published In: Molecular Psychiatry General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy The University of Edinburgh has made every reasonable effort to ensure that Edinburgh Research Explorer content complies with UK legislation. If you believe that the public display of this file breaches copyright please contact [email protected] providing details, and we will remove access to the work immediately and investigate your claim. Download date: 25. Sep. 2021 Ketamine enhances structural plasticity in mouse-mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling Laura Cavalleri MBS1, Emilio Merlo Pich MD2, Mark J. Millan PhD3, Cristiano Chiamulera PharmD, PostGrad MSc4, Tilo Kunath PhD5, PierFranco Spano PhD1 and Ginetta Collo MD1,6 1Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.