MAPK11 Antibody Cat. No.: 62-738

MAPK11 Antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma; HC = hepatocarcinoma.

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human, Mouse

This MAPK11 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 334-366 amino acids from the center region of human MAPK11.

TESTED APPLICATIONS: IHC-P, WB

For WB starting dilution is: 1:1000 APPLICATIONS: For IHC-P starting dilution is: 1:50~100

PREDICTED MOLECULAR 41 kDa WEIGHT:

October 2, 2021 1 https://www.prosci-inc.com/mapk11-antibody-62-738.html Properties

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by PURIFICATION: dialysis

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: MAPK11

Mitogen-activated protein kinase 11, MAP kinase 11, MAPK 11, Mitogen-activated protein ALTERNATE NAMES: kinase p38 beta, MAP kinase p38 beta, p38b, Stress-activated protein kinase 2b, SAPK2b, p38-2, MAPK11, PRKM11, SAPK2, SAPK2B

ACCESSION NO.: Q15759

PROTEIN GI NO.: 134047835

GENE ID: 5600

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

MAPK11 is a Ser/Thr kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. It preferentially phosphorylates transcription factor ATF2. This BACKGROUND: protein is activated by phosphorylation on threonine and tyrosine by MKK6, and is inhibited by pyridinyl-imidazole related compounds. Highest expression levels are in the brain and heart, with additional expression in the placenta, lung, liver, skeletal muscle, kidney and pancreas.

REFERENCES: 1) Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).

2) Dunham, I., et al., Nature 402(6761):489-495 (1999).

3) Enslen, H., et al., J. Biol. Chem. 273(3):1741-1748 (1998).

4) Kumar, S., et al., Biochem. Biophys. Res. Commun. 235(3):533-538 (1997).

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