Risk Management Considerations of Treating Patients with Altered Or Painful Breast Structures

Total Page:16

File Type:pdf, Size:1020Kb

Risk Management Considerations of Treating Patients with Altered Or Painful Breast Structures Risk Management Considerations of Treating Patients With Altered or Painful Breast Structures Instructor: Dr. Paul Evans Outline and CV Hour 1 of 7: Anatomy of the Breast and Anterior Thoracic Cage Course Summary: This a seven-hour course that is designed to teach the anatomy and physiology of the breasts and anterior thoracic structures while focusing on the risks associated with the prone position. Dr. Paul Evans delves into the many abnormalities, conditions, dangers, and precautions that should be taken concerning treating patients or clients in the prone position. This course also describes the common dysfunctions, surgical procedures and alterations that are done to the breasts along with the risks associated with them. This course teaches crucial information that should be understood before treating patients with altered breast structures, especially in the prone position. Learning Objective: On completion of this course each participant will have a thorough understanding of the common dysfunctions, surgical procedures and alterations of the breasts. It is designed to give a comprehensive understanding of the appropriate clinical treatment considerations of individuals with painful or altered breast structures. Risk Management exposure of practitioners, particularly with regard to patients treated in a prone position is reduced and the overall care and comfort of patients is enhanced. Outline: I. Breast Anatomy and Physiology: A. Breasts are comprised of mammary glands, ducts and fat surrounded by connective tissue. Connected to the anterior thoracic cage by suspensory ligaments of Cooper. These fibro- collagenous septa help maintain structural integrity and are often referred to as “nature’s bra”. B. Breast tissue is anterior to the Pectoralis major chest muscle. The composition of the breast tissues and the thoracic cage shape predominantly determine the breast shape, size and position. C. The ducts converge on the nipple composed of the areola (NAC) and sebaceous glands. Breasts begin developing between the ages of 9 and 14, associated with the start of puberty. D. Breast tissue is highly sensitive to the hormones estrogen and progesterone throughout the menstrual cycle and influence breast size and sensitivity to loading. Prolactin triggers milk production within the breast. E. Breasts are not fixed rigid structures, the loose connective tissue and deep fascia of the retro-mammary space allows for movement of the breast in a natural loose motion. With aging and time, connective tissue integrity decreases eventually resulting in breast ptosis. F. Four Quadrants of the Breast: 1. Upper outer (superolateral) 2. Upper inner (superomedial) 3. Lower outer (inferolateral) 4. Lower inner (inferomedial) G. Each breast lays lateral to the sternum composed of the Manubrium, body and xiphoid. Ribs 2-6 are generally posterior to the breast. The manubrium is the superior aspect and attaches to the body at the sternal angle / angle of Louis (manubriosternal junction). It is a secondary cartilaginous joint and is generally the most anterior point of the sternum at the T4 level. H. Deformity of anterior projection of the sternum is known as ‘pigeon chest’. The xiphoid is a cartilaginous process that ossifies in adulthood where it fuses to the body in a fibrous joint. I. Postpartum the xiphoid can protrude anteriorly of the body and is known as xiphodynia. Pain and sensitivity to touch and loading result. It is susceptible to fracture and can break away from the body, generally from a trauma. Laceration to the diaphragm or liver puncture may result. J. Ribs 1-7 attach directly to the sternum via the costal cartilages in sternocostal articulations which are cartilaginous joints and have generally no movement. (#1 is synarthrodial) K. Ribs 8-10 attach via their costal cartilages to each other and ultimately to rib 7. Costal cartilage articulations between Ribs 6-9 are synovial joints whilst ribs 9-10 are fibrous. L. Ribs 11-12 are floating and have no articulations. Costochondral articulations attach the sternal ends of the ribs to their costal cartilages and are hyaline cartilaginous joints. M. The blood supply to the breast skin is from the sub-dermal plexus. Communicating vessels supplying the breast parenchyma is derived from The internal mammary perforators (most notably the second to fifth perforators) The thoracoacromial artery The vessels to serratus anterior The lateral thoracic artery The terminal branches of the third to eighth intercostal perforators The supero medial perforator (from internal mammary perforators) supplies approximately 60% of breast blood supply. N. Sensory innervation of the breast is dermatomal, mainly derived from the anterolateral and antero-medial branches of thoracic intercostal nerves T1-T5. Supraclavicular nerves from the lower fibers of the cervical plexus also provide innervation to the upper and lateral portions of the breast. Nipple sensation is derived predominantly from the lateral cutaneous branch of T4. O. Lymph glands are important in cancer care because any cancer cells that have migrated from the tumor can be carried by the lymphatic fluid to the nearest lymph glands. In patients with damaged prosthetic devices migrating material can also be found in the nodes P. Lymphatic nodes are found near the breast, in the axilla, and posterior to the sternum with typical metastatic spread to the supero-lateral axillary lymph nodes. More than 75% of breast drainage via axillary lymph nodes with the remainder medially to the parasternal nodes. II. Current US Breast Statistics: 2012 US (Mexico) breast augmentation and reconstructions were approx. 500,000 Breast cancer diagnosis was 234,450 in the US with 40,350 deaths 50% of female patients between 20-45 have fibrocystic changes to their breasts with pain, tenderness and lumps. III. Patient Management- Competent Risk Management: A. Practitioners have a responsibility to manage patients with conditions of the breast and this course will educate you into what are the risks and why, what precautions you made and documentation of these corrections to protect yourself. B. HISTORY You have a patient who you did not capture the history of altered of painful breast structures. C. UNDERSTANDING Failure to demonstrate an understanding of the ramifications of the functional implications of the patients breast D. DOCUMENTATION You failed to document the fact that you realized their was a risk and that you modified and adapted your treatment. ie. Patient return with a silent rupture implant failure and blames you and you haven’t documented that you altered the patients management. Hour 2 of 7: Breast Pain, Disease and Dysfunction Course Summary: This a seven-hour course that is designed to teach the anatomy and physiology of the breasts and anterior thoracic structures while focusing on the risks associated with the prone position. Dr. Paul Evans delves into the many abnormalities, conditions, dangers, and precautions that should be taken concerning treating patients or clients in the prone position. This course also describes the common dysfunctions, surgical procedures and alterations that are done to the breasts along with the risks associated with them. This course teaches crucial information that should be understood before treating patients with altered breast structures, especially in the prone position. Learning Objective: On completion of this course each participant will have a thorough understanding of the common dysfunctions, surgical procedures and alterations of the breasts. It is designed to give a comprehensive understanding of the appropriate clinical treatment considerations of individuals with painful or altered breast structures. Risk Management exposure of practitioners, particularly with regard to patients treated in a prone position is reduced and the overall care and comfort of patients is enhanced. Outline: I. Breast Abnormalities: A. Most breast lumps in women age 20 to 50 are not cancerous and generally identified by observation and palpation of the breast. Benign changes in breast tissue can affect women (and men) of any age and are generally caused by fibrosis scar-like (fibrous) tissue and / or fluid-filled cysts. B. Fibrosis primarily is composed of the same material as ligaments and scar tissue are rubbery, firm, or hard to the touch. Fibrosis generally do not need any special treatment. Fibroadenomas are generally not removed. These benign tumors enlarge with pregnancy and breast-feeding. C. There is a type of fibroadenoma that has been associated with an increased risk of cancer, particularly in those women with a family history of the disease Cysts are movable lumps that are generally tender which build up inside the breast. Round or oval shaped fluid sacs, are generally larger and more painful pre-menstrual. Diagnosis is confirmed by mammography or ultrasound and fine-needle aspiration. They are generally aspirated. D. Lipomas are benign fatty tumors that can appear almost anywhere in the body, including the breast. They are usually not tender. Other benign lumps or tumors include, hemangiomas , hematomas, adenomyoeptheliomas, and neurofibromas. E. Sclerosing adenosis is excessive growth in the breast's lobules, often resulting in breast pain. Being microscopic and seen on mammograms as calcifications and can result in lumps. Biopsy distinguishes this condition from cancer. These lumps are usually removed through surgical biopsy. F. Fat necrosis is generally painless, presenting as round, firm lumps caused by damaged
Recommended publications
  • Breast-Reconstruction-For-Deformities
    ASPS Recommended Insurance Coverage Criteria for Third-Party Payers Breast Reconstruction for Deformities Unrelated to AMERICAN SOCIETY OF PLASTIC SURGEONS Cancer Treatment BACKGROUND Burn of breast: For women, the function of the breast, aside from the brief periods when it ■ Late effect of burns of other specified sites 906.8 serves for lactation, is an organ of female sexual identity. The female ■ Acquired absence of breast V45.71 breast is a major component of a woman’s self image and is important to her psychological sense of femininity and sexuality. Both men and women TREATMENT with abnormal breast structure(s) often suffer from a severe negative A variety of reconstruction techniques are available to accommodate a impact on their self esteem, which may adversely affect his or her well- wide range of breast defects. The technique(s) selected are dependent on being. the nature of the defect, the patient’s individual circumstances and the surgeon’s judgment. When developing the surgical plan, the surgeon must Breast deformities unrelated to cancer treatment occur in both men and correct underlying deficiencies as well as take into consideration the goal women and may present either bilaterally or unilaterally. These of achieving bilateral symmetry. Depending on the individual patient deformities result from congenital anomalies, trauma, disease, or mal- circumstances, surgery on the contralateral breast may be necessary to development. Because breast deformities often result in abnormally achieve symmetry. Surgical procedures on the opposite breast may asymmetrical breasts, surgery of the contralateral breast, as well as the include reduction mammaplasty and mastopexy with or without affected breast, may be required to achieve symmetry.
    [Show full text]
  • Surgical Approach to the Treatment of Gynecomastia According to Its Classification
    ARTIGO ORIGINAL Abordagem cirúrgica para o tratamentoVendraminFranco da T ginecomastia FSet al.et al. conforme sua classificação Abordagem cirúrgica para o tratamento da ginecomastia conforme sua classificação Surgical approach to the treatment of gynecomastia according to its classification MÁRIO MÚCIO MAIA DE RESUMO MEDEIROS1 Introdução: A ginecomastia é a proliferação benigna mais comum do tecido glandular da mama masculina, causada pela alteração do equilíbrio entre as concentrações de estrógeno e andrógeno. Na maioria dos casos, o principal tratamento é a cirurgia. O objetivo deste tra- balho foi demonstrar a aplicabilidade das técnicas cirúrgicas consagradas para a correção da ginecomastia, de acordo com a classificação de Simon, e apresentar uma nova contribuição. Método: Este trabalho foi realizado no período de março de 2009 a março de 2011, sendo incluídos 32 pacientes do sexo masculino, com idades entre 13 anos e 45 anos. A escolha da incisão foi relacionada à necessidade ou não de ressecção de pele. Foram utilizadas quatro técnicas da literatura e uma modificação da técnica por incisão circular com prolongamentos inferior, superior, lateral e medial, quando havia excesso de pele também no polo inferior da mama. Resultados: A principal causa da ginecomastia identificada entre os pacientes foi idiopática, seguida pela obesidade e pelo uso de esteroides anabolizantes. Conclusões: A técnica mais utilizada foi a incisão periareolar inferior proposta por Webster, quando não houve necessidade de ressecção de pele. Na presença de excesso de pele, a técnica escolhi- da variou de acordo com a quantidade do tecido a ser ressecado. A nova técnica proposta permitiu maior remoção do tecido dermocutâneo glandular e gorduroso da mama, quando comparada às demais técnicas utilizadas na experiência do cirurgião.
    [Show full text]
  • Benign Breast Diseases1
    BENIGN BREAST DISEASES PROFFESOR.S.FLORET NORMAL STRUCTURE DEVELOPMENTAL/CONGENITAL • Polythelia • Polymastia • Athelia • Amastia ‐ poland syndrome • Nipple inversion • Nipple retraction • NON‐BREAST DISORDERS • Tietze disease • Sebaceous cyst & other skin disorders. • Monder’s disease BENIGN DISEASE OF BREAST • Fibroadenoma • Fibroadenosis‐ ANDI • Duct ectasia • Periductal papilloma • Infective conditions‐ Mastitis ‐ Breast abscess ‐ Antibioma ‐ Retromammary abscess Trauma –fat necrosis. NIPPLE INVERSION • Congenital abnormality • 20% of women • Bilateral • Creates problem during breast feeding • Cosmetic surgery does not yield normal protuberant nipple. NIPPLE INVERSION NIPPLE RETRACTION • Nipple retraction is a secondary phenomenon due to • Duct ectasia‐ bilateral nipple retarction. • Past surgery • Carcinoma‐ short history,unilateral,palpable mass. NIPPLE RETRACTION ABERRATIONS OF NORMAL DEVELOPMENT AND INVOLUTION (ANDI) • Breast : Physiological dynamic structure. ‐ changes seen throught the life. • They are ‐ developmental & involutional ‐ cyclical & associated with pregnancy and lactation. • The above changes are described under ANDI. PATHOLOGY • The five basic pathological features are: • Cyst formation • Adenosis:increase in glandular issue • Fibrosis • Epitheliosis:proliferation of epithelium lining the ducts & acini. • Papillomatosis:formation of papillomas due to extensive epithelial hyperplasia. ANDI & CARCINOMA • NO RISK: • Mild hyperplasia • Duct ectasia. • SLIGHT INCREASED RISK(1.5‐2TIMES): • Moderate hyperplasia • Papilloma
    [Show full text]
  • Breastfeeding After Breast Surgery-V3-Formatted
    Breastfeeding After Breast and Nipple Surgeries: A Guide for Healthcare Professionals By Diana West, BA, IBCLC, RLC PURPOSE A satisfying breastfeeding relationship is not precluded by insufficient milk production. When measures are taken to protect the milk supply that exists, minimize supplementation, The purpose of this guide is to provide the healthcare and increase milk production when possible, a mother with professional with an understanding of breast and nipple compromised milk production can have a satisfying surgeries and their effects upon lactation and the breastfeeding relationship with her baby. breastfeeding relationship. The effect of breast and nipple surgery upon lactation functionality and breastfeeding dynamics varies according to the type of surgery performed. This guide has delineated discussion of breastfeeding after PREDICTING LACTATION breast and nipple surgeries according to the three broad CAPABILITY AFTER BREAST AND categories: diagnostic, ablative, and therapeutic breast procedures, cosmetic breast surgeries, and nipple surgeries. NIPPLE SURGERIES The reasons, motivations, issues, concerns, stresses, and physical and psychological results share some The aspect of breast and nipple surgeries that is most likely to commonalities, but are largely unique to the type of surgery affect lactation is the surgical treatment of the areola and performed. For this reason, each type of surgery and its nipple. The location, orientation, and length of the incision effect upon lactation will be discussed independently. directly affect lactation capability by severing the parenchyma Methods to assess milk production and an overview of and innervation to the nipple/areolar complex. An incision feeding options to maximize milk production when near or on the areola, particularly in the lower, outer quadrant supplementation is necessary are presented.
    [Show full text]
  • Breast Uplift (Mastopexy) Procedure Aim and Information
    Breast Uplift (Mastopexy) Procedure Aim and Information Mastopexy (Breast Uplift) The breast is made up of fat and glandular tissue covered with skin. Breasts may change with variable influences from hormones, weight change, pregnancy, and gravitational effects on the breast tissue. Firm breasts often have more glandular tissue and a tighter skin envelope. Breasts become softer with age because the glandular tissue gradually makes way for fatty tissue and the skin also becomes less firm. Age, gravity, weight loss and pregnancy may also influence the shape of the breasts causing ptosis (sagging). Sagging often involves loss of tissue in the upper part of the breasts, loss of the round shape of the breast to a more tubular shape and a downward migration of the nipple and areola (dark area around the nipple). A mastopexy (breast uplift) may be performed to correct sagging changes in the breast by any one or all of the following methods: 1. Elevating the nipple and areola 2. Increasing projection of the breast 3. Creating a more pleasing shape to the breast Mastopexy is an elective surgical operation and it typifies the trade-offs involved in plastic surgery. The breast is nearly always improved in shape, but at the cost of scars on the breast itself. A number of different types of breast uplift operations are available to correct various degrees of sagginess. Small degrees of sagginess can be corrected with a breast enlargement (augmentation) only if an increase in breast size is desirable, or with a scar just around the nipple with or without augmentation.
    [Show full text]
  • Phd Thesis Summary
    University of Medicine and Pharmacy of Craiova DOCTORAL SCHOOL PhD Thesis BREAST RECONSTRUCTION AFTER SURGERY FOR BREAST HIPERTROPHY AND BENIGN TUMORS Summary Ph.D. SUPERVISOR: Prof. univ. dr. Mihai Brăila Ph.D. CANDIDATE: Radu Claudiu Gabriel CRAIOVA 2013 INTRODUCTION According to statistics, only in the United States in 2012 over 14 million cosmetic surgery of the breasts were made, but only about 3% of these were for surgical breast reconstruction after mastectomy as an interventional oncology treatment, although about 300,000 women are diagnosed each year with mammary tumors and most of them suffer breast surgery that can vary from partial, segmental or total removal of the breast. This creates a major gap between the number of surgeons able to successfully carry out such intervention and the number of patients who would require them, making obvious the need to increase the number of professionals that are able to perform breast reconstruction after mastectomy, especially the aesthetic mastectomy in people diagnosed with breast hypertrophy. Based on medical literature data, in this study we aimed to elucidate, using specific research methods, the impact of clinical and psychological intervention of breast reconstruction in patients suffering from breast hypertrophy and benign tumors. We hope that our study will shade some light on the need of brest reconstruction, its impact on specific pathology (mammary hypertrophy and benign tumors) and to contribut in improving breast reconstruction techniques that can help to avoid any complication that may arise. CHAPTER I Functional anatomy of the mammary gland Adult female mammary gland is located on both side of the anterior chest having it's base stretching from about the second to the sixth rib.
    [Show full text]
  • CASE REPORT Severe Gynaecomastia Associated with Highly Active Antiretroviral Therapy Faith C
    Open Access CASE REPORT Severe gynaecomastia associated with highly active antiretroviral therapy Faith C. Muchemwa1,2, Clarice T. Madziyire2 1. Department of Surgery, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe 2. Department of Immunology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe Correspondence: Dr Faith C. Muchemwa ([email protected]) © 2018 F.C. Muchemwa & C.T. Madziyire. This open access article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), East Cent Afr J Surg. 2018 Aug;23(2):80–82 which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. https://dx.doi.org/10.4314/ecajs.v23i2.6 Abstract The association between gynaecomastia and HIV infection was first reported in 1987; however, there were no subsequent pub- lished reports of gynaecomastia linked to HIV infection until highly active antiretroviral therapy (HAART) was introduced. Although HAART significantly improves the prognosis of HIV infection, its extensive use has resulted in multiple adverse effects, including benign breast enlargement. We present a rare case of severe gynaecomastia in a male patient with vertically transmitted HIV on HAART. He was surgically treated with mastectomy with no nipple-areolar complex reconstruction. The pathology report con- firmed the benign nature of the breast tissue. Surgical intervention resulted in an improvement of daily activities and enhanced psychosocial wellbeing. Benign bilateral breast enlargement of this magnitude in a male patient has never been reported.
    [Show full text]
  • The Topic of the Lesson “Mastitis and Breast Abscess.”
    The topic of the lesson “Mastitis and breast abscess.” According to the evidence-based data from UpToDate extracted March of 19, 2020 Provide a conspectus in a format of .ppt (.pptx) presentation of not less than 50 slides containing information on: 1. Classification 2. Etiology 3. Pathogenesis 4. Diagnostic 5. Differential diagnostic 6. Treatment With 10 (ten) multiple answer questions. Lactational mastitis - UpToDate Official reprint from UpToDate® www.uptodate.com ©2020 UpToDate, Inc. and/or its affiliates. All Rights Reserved. Print Options Print | Back Text References Graphics Lactational mastitis Contributor Disclosures Author: J Michael Dixon, MD Section Editors: Anees B Chagpar, MD, MSc, MA, MPH, MBA, FACS, FRCS(C), Daniel J Sexton, MD Deputy Editors: Meg Sullivan, MD, Kristen Eckler, MD, FACOG All topics are updated as new evidence becomes available and our peer review process is complete. Literature review current through: Feb 2020. | This topic last updated: Jan 15, 2020. INTRODUCTION Lactational mastitis is a condition in which a woman's breast becomes painful, swollen, and red; it is most common in the first three months of breastfeeding. Initially, engorgement occurs because of poor milk drainage, probably related to nipple trauma with resultant swelling and compression of one or more milk ducts. If symptoms persist beyond 12 to 24 hours, the condition of infective lactational mastitis develops (since breast milk contains bacteria); this is characterized by pain, redness, fever, and malaise [1]. Issues related to lactational mastitis will be reviewed here. Issues related to other breast infections are discussed separately. (See "Nonlactational mastitis in adults" and "Primary breast abscess" and "Breast cellulitis and other skin disorders of the breast".) EPIDEMIOLOGY Lactational mastitis has been estimated to occur in 2 to 10 percent of breastfeeding women [2].
    [Show full text]
  • Breast Lift Letter
    SACRAMENTO AESTHETIC SURGERY a medical corporation Mastopexy (Breast Lift) and Breast Reduction; a letter to my patients: In some patients requesting Breast Enhancement the tissues of the breast have become lax and saggy. The medical term for this condition is Breast Ptosis. This can occur with advancing age and as a common consequence of pregnancy, nursing and/ or weight fluctuations. Breasts progressively hang lower and lower on the chest with loss of upper breast projection (perkiness), elongation and flattening. In some cases, the nipples point straight down. These changes are also very common in patients with breasts that are very large. Conceptually, the basic problem with ptotic (saggy) breasts is that the supporting elements of the breast are weak and stretchec. There is, as a result, too much skin for the amount of breast tissue present. Along with this problem, the nipple has come to rest lower on the chest wall. With early stages of breast ptosis, a breast implant may be able to make up for the volume deficit in breast tissue. However, in many women, the nipple and remainder of the breast has fallen too far down the chest to allow a simple implant to give an aesthetically pleasing result. In these women, some form of breast lift (Mastopexy) is indicated. In these women, if you only performed breast augmentation, the result would be an implant in the normal breast location with the nipple and breast appearing to have slipped off the front of the normally placed implant. Occasionally the argument is made that you can place the implant above the muscle to minimize this appearance.
    [Show full text]
  • The Effect of Breastfeeding on Breast Ptosis Following Augmentation
    Norma Cruz, MD Division of Plastic Surgery University of Puerto Rico Disclosure: Nothing to disclose. Is breast ptosis increased by breastfeeding in women with breast implants? A study was designed n=62 to evaluate the n=57 changes in breast measurements resulting from pregnancy without breastfeeding (control group) vs. pregnancy Control Group with breastfeeding Study Group (study group). Mid-clavicle to nipple Nipple to inframammary fold (IMF) Before pregnancy Measurements were made before pregnancy and one year after pregnancy or one year after completing breastfeeding. After pregnancy without breastfeeding 0 1 2 3 No ptosis (Grade 0): nipples lie above the level of the IMF Grade 1 : mild ptosis, nipples lie at the level of the IMF Grade 2 : moderate ptosis, nipples lie below the level of the IMF but remain above the lower breast contour Grade 3 : severe ptosis, nipples lie below the IMF at the lower contour of the breast Age Body mass index Bra size Duration of breastfeeding The groups were not significantly different regarding age, BMI or mean bra size (p>0.05) Control Group Study Group Age 24±5 25±6 Body mass index 23±3 22±4 Bra size 34-C 34-C The mean duration of breast feeding for the study group was 6±3 months. Control Study P Mean±SD Mean±SD Mid-clavicle to nipple (before) 21±2 cm 21±3 cm >0.05 Mid-clavicle to nipple (after) 23±3 cm 22±4 cm >0.05 Nipple to IMF (before) 6±2 cm 6±3 cm >0.05 Nipple to IMF (after) 8±3 cm 8±2 cm >0.05 Before After Before After Control Group Study Group Breast measurements were not significantly different between the groups 0 1 2 3 Control Study P Regnault’s grade (before) 0.5±1.0 0.5±1.0 >0.05 Regnault’s grade (after) 2.0±1.0 2.0±1.0 >0.05 Before After Before After Control Group Study Group The degree of breast ptosis was not significantly different between the groups.
    [Show full text]
  • Morphological Changes in Breast Tissue with Menstrual Cycle Rathi Ramakrishnan, M.D
    Morphological Changes in Breast Tissue with Menstrual Cycle Rathi Ramakrishnan, M.D. (Path.), Seema A. Khan, M.D., Sunil Badve, M.D., F.R.C.Path. Departments of Surgery (RR, SAK) and Pathology (SB), Northwestern University Medical School, Chicago, Illinois and Department of Pathology, Indiana University School of Medicine (SB), Indianapolis, Indiana retrospective analysis of large archival databases to Whether the breast tissue undergoes morphologic analyze the effect of timing of surgery in relation to changes in relation to the menstrual cycle had been menstrual cycle phase. It will also aid the design of a subject of debate. Elegant studies performed in epidemiological studies for breast cancer risk the early 1980s provided conclusive evidence of cy- assessment. clical changes in the normal breast lobules. These studies were almost entirely based on autopsy ma- KEY WORDS: Breast, Menstrual cycle classification, terial and have not been validated in the clinical Menstrual morphology. setting. In the present study, we examine breast Mod Pathol 2002;15(12):1348–1356 tissues from surgical specimens from 73 premeno- pausal women and use morphological criteria to The normal breast undergoes changes through the characterize the stage of the menstrual cycle. Pa- menstrual cycle that affect all aspects of breast tients taking oral contraceptives or hormonal ther- morphology, protein expression, and cell kinetics. apy were excluded from this study. The following This physiologic cycling appears to be disturbed in histological parameters were used to assess the women with breast cancer and may reflect a global menstrual stage: number of cell layers in the acini dysregulation of response to hormonal influences and presence and degree of vacuolation of the myo- epithelial cells, stromal edema, infiltrate, mitosis, (1, 2).
    [Show full text]
  • Aesthetic Breast Surgery GM Ref: GM006-GM010 Version: 4.3 (16 Sept 2020)
    Greater Manchester EUR Policy Statement on: Aesthetic Breast Surgery GM Ref: GM006-GM010 Version: 4.3 (16 Sept 2020) Commissioning Statement Aesthetic Breast Surgery Policy Reconstructive surgery following cancer, trauma or another significant clinical event is Exclusions not covered by this policy and is routinely commissioned across Greater Manchester. (Alternative commissioning Treatment/procedures undertaken as part of an externally funded trial or as a part of arrangements apply) locally agreed contracts / or pathways of care are excluded from this policy, i.e. locally agreed pathways take precedent over this policy (the EUR Team should be informed of any local pathway for this exclusion to take effect). Our definition All surgery involving incision into healthy tissue, in this case a healthy breast whatever of Aesthetic its size and shape, is considered to be aesthetic. This includes cases where there are symptoms, external to the breast that are attributed to, or exacerbated by, the size of the breast(s). Policy Breast Augmentation Inclusion All surgery involving incision into healthy tissue in this case a healthy breast whatever Criteria its size and shape is considered to be aesthetic. Surgery to augment the size and or shape of a breast(s) is not routinely commissioned, with the exception of proven amastia or amazia. There should be confirmation either in the form of a consultant letter or an ultrasound report that there is an absence of breast tissue. This policy applies equally to all women including those who have completed gender realignment. The period of oestrogen therapy on the realignment pathway is considered, for the purposes of this policy, to equate to the period of hormonal increase experienced in puberty.
    [Show full text]