Case Report Clinics in Surgery Published: 28 Mar, 2017

Successful Treatment of Grade III with Periareolar Excision Technique

Sadrollah Motamed1, Esmail Hasanpour1, Hamidreza Alizadeh Otaghvar2*, Mahmood Nazemian1, Daryanaz Shojaei1 and Gelavij Ghoseiri3 1Department of , Shahid Beheshti University of Medical Sciences, Iran

2Department of General Surgery, Shahid Beheshti University of Medical Science, Iran

3Department of Medicine, Iran University of Medical Sciences, Iran

Abstract As many surgical therapies have been introduced for Gynecomastia treatment, we are going to report a recent surgical technique in a male who has fatty glandular Gynecomastia grade III. In this procedure, gynecomastia will be treated by repositioning with a periareolar excision. After six months no complications were detected and the patient was completely satisfied with his new IMF (inframamary fold) and NAC (nippleareolar complex). Respectfully, we suggest this surgical technique in patients with fatty glandular Gynecomastia grade III.

Introduction A benign enlargement process in male is Gynecomastia [1]. Gynecomastia has a different prevalence rate in any age. The first peak of Gynecomastia appearance is in neonatal period which is found in 60-90% of newborns. This high rate of prevalence is called transient palpable tissue which is because of the that passed through the placenta. Puberty is the second period for Gynecomastia prevalence peak which is between 4-69% that presents palpable breast tissue and enlargement [2-4]. The last peak of Gynecomastia prevalence is in elderly who are 50-80 [5,6]. Gynecomastia has been divided by two groups, asymptomatic and symptomatic. Asymptomatic OPEN ACCESS Gynecomastia is defined as enlargement of the glandular tissue of the breast which is more common in older men [8-11]. First physical examination of asymptomatic Gynecomastia demonstrates that it *Correspondence: has been presented for months or years before we discover it. In the histological examination, dilated Hamidreza Alizade Otaghvar, ducts with periductal fibrosis, stromal hyalinization, and increased subareolar fat will be seen. In Department of General Surgery, contrast, symptomatic Gynecomastia presents with recent onset of tenderness and pain in the breast Iran University of Medical Science, area by the addition of infiltration of the periductal tissue with inflammatory cells, hyperplasia of 15 Khordad Educational Hospital, the ductal epithelium and increased subareolar fat in pathological results [7,11-13]. It seems that the Shahid Beheshti University of Medical main etiology of Gynecomastia is an imbalance between estrogen actions due to androgen action Sciences, Tehran, Iran, at the breast tissue level [14]. Concerning of surgical treatment of Gynecomastia includes two main E-mail: [email protected] conditions: I. Male chest shape retraction and countering II. Diagnose of suspected breast lesion Received Date: 12 Dec 2016 [15]. Webster classification is one of the first classifications of Gynecomastia which consists of three Accepted Date: 13 Mar 2017 types as I. Glandular, II. Fatty glandular and III. Simple fatty categories, at the other hand [16]. There Published Date: 28 Mar 2017 are two more classifications that we prefer to mention. In 1973 Simon et al. [17] suggested a 4-grade Citation: classification which is: Motamed S, Hasanpour E, Otaghvar I: Small enlargement without skin excess HA, Nazemian M, Shojaei D, Ghoseiri G. Successful Treatment of II: Moderate enlargement without skin excess Gynecomastia Grade III with Periareolar III: Moderate enlargement with minor skin excess Excision Technique. Clin Surg. 2017; III: Marked enlargement with excess skin, mimicking female breast 2: 1365. Copyright © 2017 Otaghvar HA. This is The second classification suggested by Rohrich et al. [18] which is: an open access article distributed under I. Minimal hypertrophy (<250 g) without ptosis the Creative Commons Attribution II. Moderate hypertrophy (250-500 g) without ptosis License, which permits unrestricted use, distribution, and reproduction in III. Severe hypertrophy (>500 g) with grade I ptosis any medium, provided the original work III. Severe hypertrophy with grade II or grade III ptosis is properly cited.

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Figure 1: Periareolar epithelium was removed. A: Areola B: De epithelialized Figure 4: After Surgery. C: Suctioned options during the past decades including open exision, conventional liposuction alone or in combination with residual breast tissue excision and leaving the periareolar scar is still the most important complication of these procedures. In the combination technique, liposuction accompanied by residual breast tissue excision using either a periareolar inscion or a sheet. Plus it is safe to say that the ideal procedure for treatment of predominantly fatty breasts is liposuction alone [20-24]. In patients with fibrous/glandular hyperplasia a reliquiae behind the NAC will be left [25]. Combination of periareolar liposuction with residual breast tissue removal has many obstacles. Figure 2 and 3: Before Surgery. At the other hand there is a probability of thermal burn and nipple trauma at the site of the surgery [26]. In patients with principle The aim of this article is presenting a 23 year-old single man with augmentation skin and Gynecomastia grade III exisional technique Gynecomastia grade III which his (IMF) and is still incidental. For patients who have profit of subcutaneous nippleareola complex (NAC) was below the ideal position [19]. He mastectomy as liposuction will not greatly affect firm, subareolar was treated by a new surgical technique which has no complications tissue. The gland accessibility will be provides by keeping the scar in after 6 months and the patient was completely satisfied with his new adequate spot in periareolar technique. A secondary complication breasts. that may have been occurred is changing nipple sensation, breast Case Presentation asymmetry hypertrophic or keloid scarring and nipple necrosi [25- 27]. Using just liposuction for patients who have mild to severe soft A 23 year-old single man was referred with Gynecomastia to the tissue and skin plusage, invocating nipple elevation is not suitable. In clinic affiliated to Department of Plastic and Reconstructive Surgery these cases, removing skin and soft tissue by exisional technique plus panzdah-e-khordad Hospital, Shahid beheshti University of Medical nipple areolar resizing and repositioning is required [26-28]. In this Sciences, Tehran, Iran in 2015. His past medical history was clear technique which has been chosen to decrease the post surgical scar and he did not use any oral agents or medications plus, he declined with enormous width, we used a periareolar inscion that limits the smoking and drinking alcohol. In his laboratory results liver function surgical scar just around the areola. tests (LFT), beta HCG and alpha-fetoprotein (AFP) were in normal range and nothing irregular was found in his profile. Technique His karyotype finding was 46 and XY and it was compatible with At the first step the areola circuitry and the distance between an apparently normal male from cytogenetic point of view. Severe nipple and suprasternal notch should be evaluated. The areola glandular dominant and fatty glandular Gynecomastia was detected in circuitry should be estimated as twice more than the regular size his breast sonography. As it was mentioned before, his IMF and NAC which has been provided by a skin pinch that raises the skin and were below than ideal position. On physical examination the other glandular tissue. At the other hand we marked the areola which findings were presented by lateral chest wall and upper abdominal should be suctioned around the excisional area. New nipple position laxity and high skin redundancy. In this suggested surgical technique is parallel with the middle of the arm (middle of the line that conjoint we will elevate the nipple areola complex on a thin dermoglandular the humerus head to the elbow joint. As the pictures shows (Figure1), flap which has 1 and 10 cm diameter and width respectively. After in B part, periareolar epithelium was removed (de epithelializaion) the procedure no complications such as seroma, necrosis, asymetry, and we disclosed the tissue below the periareolar area in position malposition, fever, discoloration were seen and sensation of the site of 4 to 7 o'clock with 4 cm depth approximately and the extra of the surgery was completely normal and as we mentioned before, tissue removed till 1 cm diameter of it remains below the NAC. To the patient was satisfied with his new breasts. achieve this goal, firs, the C part should be suctioned and then we Discussion start excision and delete epithelializaion (after tumescent infusion). An elliptical excision on the new IMF with internal extension was Surgical procedures of Gynecomastia treatment have had three used in patients who want to have nipple repositioning and excision

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[19,26-29]. Choosing a surgical technique is relevant to severe skin 13. Nicolis GL, Modlinger RS, Gabrilove JL. A study of the histopathology of excecc fat and glandular tissue volume, nipple position and patient human gynecomastia. J Clin Endocrinol Metab. 1971;32:173-8. and surgeon decision. As in severe cases the patient should accept 14. Braunstein GD. Aromatase and gynecomastia. Endocr Relat Cancer. the surgical scar [28]. Although, our patient with Gynecomastia grade 1999;6:315-24. III had severe skin and glandular tissue excess (Figure 2 and 3) and 15. Fischer S, Hirsch T, Hirche C, Kiefer J, Kueckelhaus M, Germann G, et al. it was so critical to gain a delicate surgical scar at site and outcome Surgical treatment of primary gynecomastia in children and adolescents. with using liposuction only or free nipple graft, we decided to use Pediatr Surg Int. 2014;30:641-7. this new technique to regenerate reduction mammoplasty and nipple 16. Venkata Ratnam is from the Department of Aesthetic and Reconstructive repositioning. The areola’s concavity based on periareolar depression, Plastic Surgery, NMC Specialty Hospital, Abu Dhabi, United Arab is the main and only complication of this procedure that will be Emirates. 2009 American Society for Aesthetic Plastic Surgery. minimized by estimating of tissue excision adjustment and applying appropriate pressure to roll up the tissue which surrounds the NAC. 17. Simon BE, Hoffman S, Kahn S. Classification and surgical correction of gynecomastia. Plast Reconstr Surg. 1973;51:48-52. The presented patient was completely satisfied with his new breast shape and nipple position while the breast symmetry, countering and 18. Rohrich RJ, Ha RY, Kenkel JM, Adams WP Jr. Classification and size was acceptable (Figure 4). The function and physical outcome management of gynecomastia: defining the role of ultrasound-assisted liposuction. Plast Reconstr Surg. 2003;1112:909-23. was satisfying although, the patient has gynecomastia grade III with severe breast ptosis. It is safe to say that, as far as this technique will 19. Hurwitz DJ. Boomerang pattern correction of gynecomastia. Plast provide such good results, considering other secondary procedures Reconstr Surg. 2015;135:433-6. may be not needed. 20. Zocchi M. Ultrasonic liposculpturing. Aesthetic Plast Surg. 1992;16:287. References 21. Fodor PB, Watson JP. Personal experience with ultrasound-assisted lipoplasty: A pilot study comparing ultrasound-assisted lipoplasty with 1. Webster GV. Gynecomastia in the Navy. The Military Surgeon. 1944. traditional lipoplasty. Plast Reconstr Surg. 1998;101:1103. 2. Braunstein GD. Gynecomastia. N Engl J Med. 1993;328:490-5. 22. Maxwell GP, Gingrass MK. Ultrasound-assisted lipoplasty: A clinical 3. Bembo SA, Carson HE. Gynecomastia: its features, and when and how to study of 250 consecutive patients. 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