Curriculum Vitae Michele Brignole, MD, FESC Department Of

Curriculum Vitae Michele Brignole, MD, FESC Department of Cardiology and Arrhythmologic Center Ospedali del Tigullio (Lavagna) Via don Bobbio 25 16033 Lavagna (GE), Italy Phone +39 0185 329569; Fax +39 0185 306506 E-mail: mbrignole@ASL4.liguria.it

PERSONAL DATA Name: Michele Brignole Date of birth: August 17, 1952 Birth place: Borzonasca (GE), Italy Citizenship: Italy

EDUCATION Years Degree Institution 1970-1976 MD University of Genoa, Italy 1977 Practical apprenticenship Lavagna General Hospital, Lavagna (Internal Medicine) (resident) 1978 Practical apprenticenship Regional General Hospital, Genoa (Cardiology) (resident) 1982-1986 Specialization University of Pavia (Cardiology), Pavia (post-graduate degree) 1987-1991 Specialization University of Genoa (Sport Medicine), Genoa (post-graduate degree)

CERTIFICATIONS 1976 State license (qualifying examination) at University of Genoa, Italy, Qualified 1987 Qualified Director of Cardiology, Italian Ministry of Health 2004 Management Training (Liguria Region), Certified 2013 Qualified Full Professor of Cardiology, Italian Ministry of Instruction, University and Research

PROFESSIONAL EXPERIENCE Full time position 1979-1980 Assistant Cardiologist, General Hospital, Casale Monferrato, Italy 1980-1984 Assistant Cardiologist, Lavagna General Hospital, Lavagna 1984-1990 Coordinator, Section of Electrophysiology, Lavagna General Hospital, Lavagna 1987-1990 Associate Cheef Cardiologist, Lavagna General Hospital, Lavagna 1990-1996 Director, Arrhythmologic Center (Clinical Cardiac Electrophysiology), Lavagna General Hospital, Lavagna 1996-Present Director, Division of Cardiology and Arrhythmologic Center, Ospedali del Tigullio, Lavagna 2009 (Oct-Dec) Visiting Professor, Division of Cardiology, University of Utah, Salt Lake City, USA

8/2015–Present Visiting Professor, Division of Cardiology, University of Wisconsin, Madison, USA

Administrative duties 1998-Present Director, Department of Cardiology, Azienda Sanitaria Locale n°4, Liguria Region

PROFESSIONAL SOCIETIES & SCIENTIFIC ACTIVITIES

Current membership in professional societies European Society of Cardiology (ESC) European Heart Rhythm Association (EHRA) Italian Asociation of Cardiac Pacing and Arrhythmology (AIAC) Gruppo Italiano per lo Studio della Sincope (GIMSI)

Fellowship 1992-Present Fellow of the European Society of Cardiology (FESC)

Administrative experience 1999-2001 Board Member, Working Group on Pacing, European Society of Cardiology 2002-2004 Educational Committee Member, European Society of Cardiology 2009-2011 Co-chair, Scientific Document Committee, European Heart Rhythm Association 2013-2015 Nominating Committee Member, European Heart Rhythm Association 2004-2006 Board Member, Italian Asociation of Cardiac Pacing and Arrhythmology 2006-2008 President, Italian Association of Cardiac Pacing and Arrhythmology 2008-2010 Past-President, Italian Asociation of Cardiac Pacing and Arrhythmology 2003-Present Board Member, Gruppo Italiano per lo Studio della Sincope 2001-2005 Advisory Committee Member, European Heart Rhythm Association 2005-2009 Programme Committee Member, European Heart Rhythm Association 2013-2017 Programme Committee Member, European Heart Rhythm Association 2013-2017 Programme Committee Member, European Society of Cardiology

Task Force for Scientific Guidelines and Consensus Documents 1995 Member, Italian Society of Cardiology Task Force on “Guidelines on the diagnostic assessment of patients with syncope” 1999 Chair, ESC Working Group on Pacing Task force on “Report of a study group on ablate and pace therapy for paroxysmal atrial fibrillation” 2000 Member, AIAC Task Force on “The tilt test enhanced with oral nitroglycerin in patients with unexplained syncope: the Italian Protocol” 1999-2004 Chair, ESC Task Force on “Management (Diagnosis and Treatment) of Syncope”, version 2001 and 2004 2007 Reviewer, ESC Task Force on “Guidelines for cardiac pacing and cardiac resynchronization therapy” 2007-2008 Member, EHRA Task Force on “Consensus document on antithrombotic therapy in the setting of electrophysiological procedures” 2008-2009 Chair, EHRA Task Force on “Indications for the use of diagnostic implantable

and external ECG loop recorders 2008-2009 Member, ESC Task Force on “Management (Diagnosis and Treatment) of Syncope”, version 2009 2

2011-2013 Chair, ESC Task Force on “Guidelines for cardiac pacing and cardiac resynchronization therapy” 2012 Member, ESC task force on “ Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012” 2015 Member, HRS Expert Consensus Statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope 2105 Co-chair, EHRA Position Paper “Syncope Unit: rationale and requirement”. 2015-2018 Chair, ESC Task Force on “Management (Diagnosis and Treatment) of Syncope”, version 2018

Scientific Journals experience Manuscript reviewer for: The New England Journal of Medicine The Lancet JAMA JAMA Internal Medicine Annals of Internal Medicine Circulation Circulation Arrhythmia & Electrophysiology Journal of the American College of Cardiology (“Elite Reviewer 2012 and 2013”), JACC Electrophysiology European Heart Journal American Journal of Cardiology Heart Heart Rhythm Pacing and Clinical electrophysiology Stroke Europace Journal of Interventional Cardiac Electrophysiology Journal of Cardiovascualr Electrophysiology Journal of the American Medical Association Nature Cardiology Review

Member of the Editorial Board of: European Heart Journal Journal of the American College of Cardiology Heart Rhythm Europace Journal of Interventional Cardiac Electrophysiology Cardiovascular medicine (official journal of FIC) Journal of Arrhythmia (official journal of JHRS and APHRS) Giornale Italiano di Cardiologia (uffical journal of FIC) Emergency care Journal International Journal of cardiology

Educational course 2000-Present Course Director, “Tigullio Cardiologia”, bi-annual National Multidisciplinary Teaching Course on Cardiology organized by Department of Cardiology, Ospedali del Tigullio, Lavagna 2003-Present Board and Organizing Committee member, Bi-annual National Multidisciplanry Congress on Syncope of the GIMSI (Gruppo Italiano Multidisciplinare per lo Studio della Sincope) Oct 3-5, 2002 Course Director, “A Multidisciplinary Symposium based on the ESC Management of Syncope Guidelines“ organized by European Society of Cardiology

BOOKS (international publishing co.) Editor and chapters autor Syncope: an evidence-based approach, Springer, 2011 Co-Editor 1- The evaluation and treatment of syncope, Blackwell Futura, 2003 2- The evaluation and treatment of syncope (second edition), Blackwell Futura, 2006 3- Syncope cases, Blackwell Futura, 2006 4- Syncope and transient loss of consciousness, Blackwell Futura, 2007 Section Coordinator 1- Syncope Section (total 6 chapters) in The ESC Textbook of Cardiovascular Medicine 3rd Edition, Oxford, 2018 Book chapter 1- Chp 31. Syncope. In The ESC Textbook of Cardiovascular Medicine, Blackwell, 2006 2- Chp 26. Syncope. In The ESC Textbook of Cardiovascular Medicine (second edition), Blackwell, 2009 3- Chp 9. Paroxysmal atrial fibrillation in a patient with hypertrophic cardiomyiopathy. In Atrial Fibrillation, Prous Science, 2000 4- Chp 16. Treatment of atrial tachyarrhythmias with ablation and pacing. In Advances in the treatment of atrial tachyarrhythmias. Futura, 2002 5- Sick Sinus Syndrome. In Clinics in Geriatric Medicine. WB Saunders, 2002 6- Chp 7. Tilt Table Testing. In Syncope. Mechanism and Mangement (second edition), Blackwell Futura, 2005 7- Chp 2. Electrophysiological study in the diagnosis of syncope. In: A practical approach to clinical electrophysiology. Marge 2010 8- Chp 7. Role of Adenosine. In: Vasovagal Syncope. Springer 2015 9- Chp 15. Pacing in reflex (neurally-mediated) syncopes. In: Clinical Cardiac Pacing. Elsevier 2016

PEER-REVIEWED JOURNAL ARTICLES

Medline: total 293 articles of which first author in 123 and senior author in 46 Scopus: total 350 documents; citations:16691 in 8892 documents; h-index: 59 (since 1996) ; co-authors >150

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Guidelines and Consensus Documents (total 18)

Syncope Unit: rationale and requirement--the European Heart Rhythm Association position statement endorsed by the Heart Rhythm Society. Kenny RA, Brignole M, Dan GA, Deharo JC, van Dijk JG, Doherty C, Hamdan M, Moya A, Parry SW, Sutton R, Ungar A, Wieling W. Europace. 2015 Sep;17(9):1325-40. doi: 10.1093/europace/euv115. Epub 2015 Jun 24.

2015 Heart Rhythm Society Expert Consensus Statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope. Sheldon RS(1), Grubb BP 2nd(2), Olshansky B(3), Shen WK(4), Calkins H(5), Brignole M(6), Raj SR(7), Krahn AD(8), Morillo CA(9), Stewart JM(10), Sutton R(11), Sandroni P(12), Friday KJ(13), Hachul DT(14), Cohen MI(15), Lau DH(16), Mayuga KA(17), Moak JP(18), Sandhu RK(19), Kanjwal K(20). Heart Rhythm. 2015 Jun;12(6):e41-63. doi: 10.1016/j.hrthm.2015.03.029. Epub 2015 May 14.

2013 ESC guidelines on cardiac pacing and cardiac resynchronization therapy: Brignole M, Auricchio A, Baron-Esquivias G, Bordachar P, Boriani G, Breithardt OA, Cleland J, Deharo JC, Delgado V, Elliott PM, Gorenek B, Israel CW, Leclercq C, Linde C, Mont L, Padeletti L, Sutton R, Vardas PE Eur Heart J. 2013 Aug;34(29):2281-329. doi: 10.1093/eurheartj/eht150. Epub 2013 Jun 24. PubMed PMID: 23801822. and Europace. 2013 Aug;15(8):1070-118. doi: 10.1093/europace/eut206. Epub 2013 Jun 24. PubMed PMID: 23801827.

2012 EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management. Daubert JC, Saxon L, Adamson PB, Auricchio A, Berger RD, Beshai JF, Breithard O, Brignole M, Cleland J, Delurgio DB, Dickstein K, Exner DV, Gold M, Grimm RA, Hayes DL, Israel C, Leclercq C, Linde C, Lindenfeld J, Merkely B, Mont L, Murgatroyd F, Prinzen F, Saba SF, Shinbane JS, Singh J, Tang AS, Vardas PE, Wilkoff BL, Zamorano JL Heart Rhythm. 2012 Sep;9(9):1524-76. doi: 10.1016/j.hrthm.2012.07.025. PubMed PMID: 22939223. and Europace. 2012 Sep;14(9):1236-86. doi: 10.1093/europace/eus222. PubMed PMID: 22930717

AIAC guidelines on the management and treatment of atrial fibrillation. Update 2013. Associazione Italiana di Aritmologia e Cardiostimolazione Raviele A, Disertori M, Alboni P, Bertaglia E, Botto G, Brignole M, Cappato R, Capucci A, Del Greco M, De Ponti R, Di Biase M, Di Pasquale G, Gulizia M, Lombardi F, Themistoclakis S, Tritto M; G Ital Cardiol (Rome). 2013 Mar;14(3):215-40. doi: 10.1714/1234.13660. Italian. PubMed PMID: 23474607.

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Böhm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Sanchez MA, Jaarsma T, Køber L, Lip GY, Maggioni AP, Parkhomenko A, Pieske BM, Popescu BA, Rønnevik PK, Rutten FH, Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA, Zannad F, Zeiher A; ESC Committee for Practice Guidelines (CPG), Bax JJ, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, Funck-Brentano C, Hasdai D, Hoes A, Kirchhof P, Knuuti J, Kolh P, McDonagh T, Moulin C, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Torbicki A, Vahanian A, Windecker S; Document Reviewers, McDonagh T, Sechtem U, Bonet LA, Avraamides P, Ben Lamin HA, Brignole M, Coca A, Cowburn P, Dargie H, Elliott P, Flachskampf FA, Guida GF, Hardman S, Iung B, Merkely B, Mueller C, Nanas JN, Nielsen OW, Orn S, Parissis JT, Ponikowski P. Eur Heart J. 2012 May 19. [Epub ahead of print] PubMed PMID: 22611136.

AIAC (Associazione Italiana di Aritmologia e Cardiostimolazione). Structure and functional organization of arrhythmology. Vergara G, Brignole M, Alboni P, Curnis A, Feraco E, Gulizia MM, Lunati M, Pedretti R, Raviele A, Salerno-Uriarte J, Berisso MZ; G Ital Cardiol (Rome). 2010 Jul-Aug;11(7-8):604-24. Italian. PubMed PMID: 21033340.

ESC Guidelines for the diagnosis and management of syncope (version 2009). Moya A, Sutton R, Ammirati F, Blanc JJ, Brignole M, Dahm JB, Deharo JC, Gajek J, Gjesdal K, Krahn A, Massin M, Pepi M, Pezawas T, Ruiz Granell R, Sarasin F, Ungar A, van Dijk JG, Walma EP, Wieling W. Eur Heart J. 2009 Nov;30(21):2631-71. Epub 2009 Aug 27. PubMed PMID: 19713422; PubMed Central PMCID: PMC3295536.

EHRA Scientific Documents. Indications for the use of diagnostic implantable and external ECG loop recorders. Brignole M, Vardas P, Hoffman E, Huikuri H, Moya A, Ricci R, Sulke N, Wieling W. Europace. 2009 May;11(5):671-87. PubMed PMID: 19401342.

Scientific Initiatives Committee of the European Heart Rhythm Association. Consensus document on antithrombotic therapy in the setting of electrophysiological procedures. Blanc JJ, Almendral J, Brignole M, Fatemi M, Gjesdal K, González-Torrecilla E, Kulakowski P, Lip GY, Shah D, Wolpert C 6

Europace. 2008 May;10(5):513-27. PubMed PMID: 18442963.

ESC Guidelines for cardiac pacing and cardiac resynchronization therapy Vardas PE, Auricchio A, Blanc JJ, Daubert JC, Drexler H, Ector H, Gasparini M, Linde C, Morgado FB, Oto A, Sutton R, Trusz-Gluza M, Vahanian A, Camm J, De Caterina R, Dean V, Dickstein K, Funck-Brentano C, Filippatos G, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL, Priori SG, Blomström-Lundqvist C, Brignole M, Terradellas JB, Camm J, Castellano P, Cleland J, Farre J, Fromer M, Le Heuzey JY, Lip GY, Merino JL, Montenero AS, Ritter P, Schalij MJ, Stellbrink C. Eur Heart J. 2007 Sep;28(18):2256-95. Epub 2007 Aug 28. PubMed PMID: 17726042.

European Society of Cardiology. Guidelines on management (diagnosis and treatment) of syncope- update 2004. Executive Summary Brignole M, Alboni P, Benditt DG, Bergfeldt L, Blanc JJ, Bloch Thomsen PE, Gert van Dijk J, Fitzpatrick A, Hohnloser S, Janousek J, Kapoor W, Anne Kenny R, Kulakowski P, Masotti G, Moya A, Raviele A, Sutton R, Theodorakis G, Ungar A, Wieling W Eur Heart J. 2004 Nov;25(22):2054-72. PubMed PMID: 15541843. and Rev Esp Cardiol. 2005 Feb;58(2):175-93. Spanish. PubMed PMID: 15743564.

European Society of Cardiology. Guidelines on management (diagnosis and treatment) of syncope-- update 2004. Brignole M, Alboni P, Benditt DG, Bergfeldt L, Blanc JJ, Bloch Thomsen PE, van Dijk JG, Fitzpatrick A, Hohnloser S, Janousek J, Kapoor W, Kenny RA, Kulakowski P, Masotti G, Moya A, Raviele A, Sutton R, Theodorakis G, Ungar A, Wieling W. Europace. 2004 Nov;6(6):467-537. PubMed PMID: 15519256.

European Society of Cardiology. Guidelines on management (diagnosis and treatment) of syncope. Brignole M, Alboni P, Benditt D, Bergfeldt L, Blanc JJ, Bloch Thomsen PE, van Dijk JG, Fitzpatrick A, Hohnloser S, Janousek J, Kapoor W, Kenny RA, Kulakowski P, Moya A, Raviele A, Sutton R, Theodorakis G, Wieling W. Eur Heart J. 2001 Aug;22(15):1256-306. PubMed PMID: 11465961.

European Society of Cardiology. Part 1. The initial evaluation of patients with syncope. Brignole M, Alboni P, Benditt D, Bergfeldt L, Blanc JJ, Bloch Thomsen PE, Fitzpatrick A, Hohnloser S, Kapoor W, Kenny RA, Theodorakis G, Kulakowski P, Moya A, Raviele A, Sutton R, Wieling W, Janousek J, van Dijk G Europace. 2001 Oct;3(4):253-60. PubMed PMID: 11678381. and Part 2. Diagnostic tests and treatment: summary of recommendations. Brignole M, Alboni P, Benditt D, Bergfeldt L, Blanc JJ, Bloch Thomsen PE, Fitzpatrick A, Hohnloser S, Kapoor W, Kenny RA, Theodorakis G, Kulakowski P, Moya A, Raviele A, Sutton R, Wieling W, Janousek J, van Dijk G Europace. 2001 Oct;3(4):261-8. PubMed PMID: 11678382.

AIAC (Associazione Italiana di Aritmologia e Cardiostimolazione) The tilt test enhanced with oral nitroglycerin in patients with unexplained syncope: the Italian Protocol. Bartoletti A, Alboni P, Ammirati F, Brignole M, Del Rosso A, Foglia Manzillo G, Menozzi C, Raviele A Ital Heart J Suppl. 2000 Feb;1(2):226-31. Italian. PubMed PMID: 10731380.

Working Group on Arrhythmias of the European Society of Cardiology. Report of a study group on ablate and pace therapy for paroxysmal atrial fibrillation.

Brignole M, Gammage M, Jordaens L, Sutton R. Europace. 1999 Jan;1(1):8-13. PubMed PMID: 11220546.

ANMCO (Associazione Italiana Medici Cardiologi Ospedalieri). Guidelines on the diagnostic assessment of patients with syncope Alboni P, Raviele A, Vecchio C, Andrioli G, Brignole M, Menozzi C, Piccolo E, Proclemer A. G Ital Cardiol. 1995 Jul;25(7):937-48. Italian. PubMed PMID: 7557043.

Top 20 recent articles

Solari D, Tesi F, Unterhuber M, Gaggioli G, Ungar A, Tomaino M, Brignole M. Stop vasodepressor drugs in reflex syncope: a randomised controlled trial. Heart. 2017 Mar;103(6):449-455. doi: 10.1136/heartjnl-2016-309865. Epub 2016 Sep 23. PubMed PMID: 27664002.

Brignole M, Guieu R, Tomaino M, Iori M, Ungar A, Bertolone C, Unterhuber M, Bottoni N, Tesi F, Claude Deharo J. Mechanism of syncope without prodromes with normal heart and normal electrocardiogram. Heart Rhythm. 2017 Feb;14(2):234-239. doi: 10.1016/j.hrthm.2016.08.046. Epub 2016 Sep 14. PubMed PMID: 27639455.

Donateo P, Bottoni N, Oddone D, Quartieri F, Iori M, Maggi R, Brignole M. Long-Term Results After Single and Multiple Procedures of Ablation of Ventricular Tachycardia. J Cardiovasc Electrophysiol. 2016; 27: 1319-1324 doi: 10.1111/jce.13061. PubMed PMID: 27489134.

Brignole M, Solari D, Iori M, Bottoni N, Guieu R, Deharo JC. Efficacy of theophylline in patients affected by low adenosine syncope. Heart Rhythm. 2016 May;13(5):1151-4. doi: 10.1016/j.hrthm.2015.12.016. Epub 2015 Dec 9. PubMed PMID: 26690065.

Brignole M, Arabia F, Ammirati F, Tomaino M, Quartieri F, Rafanelli M, Del Rosso A, Rita Vecchi M, Russo V, Gaggioli G; Standardized algorithm for cardiac pacing in older patients affected by severe unpredictable reflex syncope: 3-year insights from the Syncope Unit Project 2 (SUP 2) study. Europace. 2015 Nov 26. pii: euv343. [Epub ahead of print] PubMed PMID: 26612880.

Guieu R, Deharo JC, Ruf J, Mottola G, Kipson N, Bruzzese L, Gerolami V, Franceschi F, Ungar A, Tomaino M, Iori M, Brignole M. Adenosine and Clinical Forms of Neurally-Mediated Syncope. J Am Coll Cardiol. 2015 Jul 14;66(2):204-5. doi: 10.1016/j.jacc.2015.04.066.

Brignole M, Ammirati F, Arabia F, Quartieri F, Tomaino M, Ungar A, Lunati M, Russo V, Del Rosso A, Gaggioli G; Assessment of a standardized algorithm for cardiac pacing in older patients affected by severe unpredictable reflex syncopes. Eur Heart J. 2015 Jun 21;36(24):1529-35. doi: 10.1093/eurheartj/ehv069. Epub 2015 Mar 29. PubMed PMID: 25825044.

Sutton R, Brignole M. Twenty-eight years of research permit reinterpretation of tilt-testing: hypotensive susceptibility rather than diagnosis. Eur Heart J. 2014 Sep 1;35(33):2211-2. doi: 10.1093/eurheartj/ehu255. Epub 2014 Jun 30. PubMed PMID: 24980488.

Brignole M, Donateo P, Tomaino M, Massa R, Iori M, Beiras X, Moya A, Kus T, Deharo JC, Giuli S, Gentili A, Sutton R Benefit of pacemaker therapy in patients with presumed neurally mediated syncope and documented asystole is greater when tilt test is negative: an analysis from the third International Study on Syncope of Uncertain Etiology (ISSUE-3). Circ Arrhythm Electrophysiol. 2014 Feb;7(1):10-6. doi: 10.1161/CIRCEP.113.001103. Epub 2013 Dec 12. PubMed PMID: 24336948.

Deharo JC, Guieu R, Mechulan A, Peyrouse E, Kipson N, Ruf J, Gerolami V, Devoto G, Marrè V, Brignole M. Syncope without prodromes in patients with normal heart and normal electrocardiogram: a distinct entity. J Am Coll Cardiol. 2013 Sep 17;62(12):1075-80. doi: 10.1016/j.jacc.2013.05.060. Epub 2013 Jun 27. PubMed PMID: 23810895.

Brignole M, Occhetta E, Bongiorni MG, Proclemer A, Favale S, Iacopino S, Calò L, Vado A, Buja G, Mascioli G, Quartieri F, Tritto M, Parravicini U, Castro A, Tomasi C, Villani GQ, D'Acri MG, Klersy C, Gasparini M. Clinical evaluation of defibrillation testing in an unselected population of 2,120 consecutive patients undergoing first implantable cardioverter-defibrillator implant. J Am Coll Cardiol. 2012 Sep 11;60(11):981-7. doi: 10.1016/j.jacc.2012.05.014. Epub 2012 Aug 1. PubMed PMID: 22858384.

Brignole M, Menozzi C, Moya A, Andresen D, Blanc JJ, Krahn AD, Wieling W, Beiras X, Deharo JC, Russo V, Tomaino M, Sutton R. Pacemaker Therapy in Patients With Neurally Mediated Syncope and Documented Asystole: Third International Study on Syncope of Uncertain Etiology (ISSUE-3): A Randomized Trial. Circulation. 2012 May 29;125(21):2566-2571. Epub 2012 May 7. PubMed PMID: 22565936.

Brignole M, Botto G, Mont L, Iacopino S, De Marchi G, Oddone D, Luzi M, Tolosana JM, Navazio A, Menozzi C. Cardiac resynchronization therapy in patients undergoing atrioventricular junction ablation for permanent atrial fibrillation: a randomized trial. Eur Heart J. 2011 Oct;32(19):2420-9. Epub 2011 May 23. PubMed PMID: 21606084.

Brignole M, Deharo JC, De Roy L, Menozzi C, Blommaert D, Dabiri L, Ruf J, Guieu R. Syncope due to idiopathic paroxysmal atrioventricular block: long-termfollow-up of a distinct form of atrioventricular block. J Am Coll Cardiol. 2011 Jul 5;58(2):167-73. Epub 2011 May 12. PubMed PMID: 21570228.

Brignole M, Ungar A, Casagranda I, Gulizia M, Lunati M, Ammirati F, Del Rosso A, Sasdelli M, Santini M, Maggi R, Vitale E, Morrione A, Francese GM, Vecchi MR, Giada F. Prospective multicentre systematic guideline-based management of patients referred to the Syncope Units of general hospitals. Europace. 2010 Jan;12(1):109-18. Epub . PubMed PMID: 19948566.

Ungar A, Del Rosso A, Giada F, Bartoletti A, Furlan R, Quartieri F, Lagi A, Morrione A, Mussi C, Lunati M, De Marchi G, De Santo T, Marchionni N, Brignole M Early and late outcome of treated patients referred for syncope to emergency department: the EGSYS 2 follow-up study. Eur Heart J. 2010 Aug;31(16):2021-6. Epub 2010 Feb 18. PubMed PMID: 20167743.

Brignole M, Sutton R, Menozzi C, Garcia-Civera R, Moya A, Wieling W, Andresen D, Benditt DG, Grovale N, De Santo T, Vardas P. Lack of correlation between the responses to tilt testing and adenosine triphosphate test and the mechanism of spontaneous neurally mediated syncope. Eur Heart J. 2006 Sep;27(18):2232-9. Epub 2006 Jul 24. PubMed PMID: 16864606.

Brignole M, Sutton R, Menozzi C, Garcia-Civera R, Moya A, Wieling W, Andresen D, Benditt DG, Vardas P. Early application of an implantable loop recorder allows effective specific therapy in patients with recurrent suspected neurally mediated syncope. Eur Heart J. 2006 May;27(9):1085-92. Epub 2006 Mar 28. PubMed PMID: 16569653.

Brignole M, Menozzi C, Bartoletti A, Giada F, Lagi A, Ungar A, Ponassi I, Mussi C, Maggi R, Re G, Furlan R, Rovelli G, Ponzi P, Scivales A. A new management of syncope: prospective systematic guideline-based evaluation of patients referred urgently to general hospitals. Eur Heart J. 2006 Jan;27(1):76-82. Epub 2005 Nov 4. PubMed PMID: 16272210.

Brignole M, Gammage M, Puggioni E, Alboni P, Raviele A, Sutton R, Vardas P, Bongiorni MG, Bergfeldt L, Menozzi C, Musso G. Comparative assessment of right, left, and biventricular pacing in patients with permanent atrial fibrillation. Eur Heart J. 2005 Apr;26(7):712-22. Epub 2004 Dec 20. PubMed PMID: 15618036

Most cited articles (top 20 from Scopus)

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012. Mcmurray, J.J.V.,Adamopoulos, S.,Anker, S.D et al European Journal of Heart Failure 2012

Guidelines for the diagnosis and management of syncope (version 2009) Moya, A.,Sutton, R.,Ammirati, F et al. European Heart Journal 2009

2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy Brignole, M.,Auricchio, A.,Baron-Esquivias, G.et al. European Heart Journal 2013

Guidelines on management (diagnosis and treatment) of syncope Brignole, M.,Alboni, P.,Benditt, D et al. European Heart Journal 2001

Guidelines for cardiac pacing and cardiac resynchronization therapy Vardas, P.E.,Auricchio, A.,Blanc, J.-J et al. European Heart Journal 2007

Guidelines on Management (diagnosis and treatment) of syncope - Update 2004 10

Brignole, M.,Alboni, P.,Benditt, D.G.et al. Europace 2004

Clinical and genetic heterogeneity of right bundle branch block and ST-segment elevation syndrome: A prospective evaluation of 52 families Priori, S.G.,Napolitano, C.,Gasparini, M.et al. Circulation 2000

Dual-chamber pacing in the treatment of neurally mediated tilt-positive cardioinhibitory syncope: Pacemaker versus no therapy: A multicenter randomized study Sutton, R.,Brignole, M.,Menozzi, C.et al. Circulation 2000

Diagnostic value of history in patients with syncope with or without heart disease Alboni, P.,Brignole, M.,Menozzi,C et al Journal of the American College of Cardiology 2001

Mechanism of syncope in patients with isolated syncope and in patients with tilt-positive syncope Moya, A.,Brignole, M.,Menozzi, C et al. Circulation 2001

2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy Brignole, M.,Auricchio, A.,Baron-Esquivias, G.et al. Europace 2013

Assessment of atrioventricular junction ablation and VVIR pacemaker versus pharmacological treatment in patients with heart failure and chronic atrial fibrillation: A randomized, controlled study Brignole, M.,Menozzi, C.,Gianfranchi, L.et al. Circulation 1998

Full list of articles: see Appendix

Updated November 2017